Annotation Cluster 1 Enrichment Score: 64.01857362726544 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS transcription regulation 74 91.35802469135803 9.293275979310614E-71 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, HEY1, GATA6, GATA4, RARA, RARB, NR2F2, EGR1, RARG, RXRB, RXRA, RELA, ARNTL, MECOM, PROX1, HHEX, HIF1A, JUN, ZFPM2, FOXC1, NFE2L2, ZFPM1, CLOCK, SOX4, SOX6, NR3C1, SRF, TCF7L1, ARNT, ATF2, NR1H2, TCF21, TAL1, TFAM, HAND2, NFAT5, PBRM1, BCL6, NFATC4, NFATC3, NFATC1, TRP53, EPAS1, MAFB, JARID2, SMAD7, TBX2, CREB1, SMAD6, TBX5, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT1, FOXP4, STAT3, FOXP1, MEF2D, SP1, ETS1, HOPX, PBX1, KLF2, RERE, NCOR2 80 1546 17854 10.682373868046572 6.598225945310535E-69 6.598225945310535E-69 9.645653029599353E-68 SP_PIR_KEYWORDS Transcription 75 92.5925925925926 1.706342679036987E-68 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, HEY1, GATA6, GATA4, RARA, RARB, NR2F2, EGR1, RARG, RXRB, RXRA, RELA, ARNTL, MECOM, PROX1, HHEX, HIF1A, JUN, ZFPM2, FOXC1, NFE2L2, ZFPM1, CLOCK, SOX4, SOX6, NR3C1, SRF, MEIS1, TCF7L1, ARNT, ATF2, NR1H2, TCF21, TFAM, TAL1, HAND2, NFAT5, PBRM1, BCL6, NFATC4, NFATC3, NFATC1, TRP53, EPAS1, MAFB, JARID2, SMAD7, TBX2, CREB1, SMAD6, TBX5, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT1, FOXP4, STAT3, FOXP1, MEF2D, SP1, ETS1, HOPX, PBX1, KLF2, RERE, NCOR2 80 1769 17854 9.461913510457887 1.2115033021162608E-66 6.057516510581304E-67 1.7710427913934308E-65 GOTERM_BP_FAT GO:0006350~transcription 73 90.12345679012346 5.5468194568520094E-55 MEF2C, MEF2A, THRA, TBX20, FOXO1, RORA, GATA2, HEY1, GATA6, GATA4, RARA, RARB, NR2F2, EGR1, RARG, RXRB, RXRA, RELA, ARNTL, PROX1, HHEX, HIF1A, JUN, ZFPM2, FOXC1, NFE2L2, ZFPM1, CLOCK, SOX4, SOX6, NR3C1, SRF, MEIS1, TCF7L1, ARNT, ATF2, NR1H2, TCF21, TAL1, TFAM, HAND2, NFAT5, PBRM1, BCL6, NFATC4, NFATC3, NFATC1, TRP53, EPAS1, MAFB, JARID2, SMAD7, TBX2, CREB1, SMAD6, TBX5, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT1, FOXP4, STAT3, FOXP1, MEF2D, SP1, ETS1, HOPX, PBX1, KLF2, RERE, NCOR2 81 1772 13588 6.910821280271995 6.201344152760546E-52 1.2402688305521093E-52 8.888367902192675E-52 Annotation Cluster 2 Enrichment Score: 60.597016354949794 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003677~DNA binding 80 98.76543209876543 1.7007164758749513E-68 MEF2C, MEF2A, THRA, TBX20, PRRX1, FOXO1, FOXO3, RORA, GATA2, HEY1, GATA6, GATA4, RARA, RARB, NR2F2, EGR1, RARG, RXRB, RXRA, RELA, ARNTL, MECOM, PROX1, HHEX, HIF1A, JUN, ZFPM2, FOXC1, NFE2L2, ZFPM1, CLOCK, IRX4, SOX4, SOX6, NR3C1, SRF, MEIS1, TCF7L1, ARNT, ATF2, NR1H2, TCF21, TFAM, TAL1, HAND2, NFAT5, PBRM1, BCL6, NFATC4, NFATC3, NKX2-5, NFATC1, TRP53, EPAS1, MAFB, JARID2, SMAD7, TBX2, CREB1, SMAD6, TBX5, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT1, FOXP4, STAT3, FOXP1, ATRX, MEF2D, SP1, ETS1, ETS2, HOPX, PBX1, KLF2, NCOR2, RERE 81 1781 13288 7.36886615232114 1.2245158626299649E-66 4.081719542099883E-67 1.7702359902841792E-65 GOTERM_BP_FAT GO:0045449~regulation of transcription 80 98.76543209876543 1.8583792188043095E-61 MEF2C, MEF2A, THRA, TBX20, PRRX1, FOXO1, FOXO3, RORA, GATA2, HEY1, GATA6, GATA4, RARA, RARB, NR2F2, EGR1, RARG, RXRB, RXRA, RELA, ARNTL, MECOM, PROX1, HHEX, HIF1A, JUN, ZFPM2, FOXC1, NFE2L2, ZFPM1, CLOCK, IRX4, SOX4, SOX6, NR3C1, SRF, MEIS1, TCF7L1, ARNT, ATF2, NR1H2, TCF21, TFAM, TAL1, HAND2, NFAT5, PBRM1, BCL6, NFATC4, NFATC3, NKX2-5, NFATC1, TRP53, EPAS1, MAFB, JARID2, SMAD7, TBX2, CREB1, SMAD6, TBX5, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT1, FOXP4, STAT3, FOXP1, ATRX, MEF2D, SP1, ETS1, ETS2, HOPX, PBX1, KLF2, NCOR2, RERE 81 2227 13588 6.026154878123147 2.077667966623218E-58 6.92555988874406E-59 2.977915240799377E-58 SP_PIR_KEYWORDS nucleus 80 98.76543209876543 5.11899465159754E-54 MEF2C, MEF2A, THRA, TBX20, PRRX1, FOXO1, FOXO3, RORA, GATA2, HEY1, GATA6, GATA4, RARA, RARB, NR2F2, EGR1, RARG, RXRB, RXRA, RELA, ARNTL, MECOM, PROX1, HHEX, HIF1A, JUN, ZFPM2, FOXC1, NFE2L2, ZFPM1, CLOCK, IRX4, SOX4, SOX6, NR3C1, SRF, MEIS1, TCF7L1, ARNT, ATF2, NR1H2, TCF21, TFAM, TAL1, HAND2, NFAT5, PBRM1, BCL6, NFATC4, NFATC3, NKX2-5, NFATC1, TRP53, EPAS1, MAFB, JARID2, SMAD7, TBX2, CREB1, SMAD6, TBX5, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT1, FOXP4, STAT3, FOXP1, ATRX, MEF2D, SP1, ETS1, ETS2, HOPX, PBX1, KLF2, NCOR2, RERE 80 3808 17854 4.688550420168067 3.634486202634253E-52 9.086215506585633E-53 5.3130937227743306E-51 Annotation Cluster 3 Enrichment Score: 48.4261185221969 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045941~positive regulation of transcription 50 61.72839506172839 1.9137478222587584E-51 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 475 13588 17.658219623131902 2.1395700652852918E-48 3.56595010880882E-49 3.0666393324273856E-48 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 48 59.25925925925925 6.41932939819584E-51 MEF2C, THRA, TBX20, SOX4, FOXO1, SOX6, RORA, FOXO3, SRF, TCF7L1, ARNT, TCF21, GATA2, HAND2, GATA6, GATA4, NFAT5, RARA, RARB, NFATC3, NKX2-5, EGR1, TRP53, RARG, EPAS1, MAFB, RXRB, RELA, RXRA, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, MECOM, STAT3, HIF1A, SP1, ETS1, JUN, PBX1, ZFPM2, FOXC1, NFE2L2, CLOCK 81 416 13588 19.356125356125354 7.17681026718295E-48 1.0252586095975643E-48 1.0286500546911172E-47 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 50 61.72839506172839 7.478684277525446E-51 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 488 13588 17.18781623153208 8.361169022273448E-48 1.045146127784181E-48 1.1984038384533222E-47 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 48 59.25925925925925 9.112320174197614E-51 MEF2C, THRA, TBX20, SOX4, FOXO1, SOX6, RORA, FOXO3, SRF, TCF7L1, ARNT, TCF21, GATA2, HAND2, GATA6, GATA4, NFAT5, RARA, RARB, NFATC3, NKX2-5, EGR1, TRP53, RARG, EPAS1, MAFB, RXRB, RELA, RXRA, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, MECOM, STAT3, HIF1A, SP1, ETS1, JUN, PBX1, ZFPM2, FOXC1, NFE2L2, CLOCK 81 419 13588 19.217537346415625 1.0187573954752933E-47 1.1319526616392148E-48 1.4601819075035701E-47 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 50 61.72839506172839 6.884026740175233E-50 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 510 13588 16.44638102154442 7.69634189551591E-47 7.69634189551591E-48 1.1031143665515219E-46 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 50 61.72839506172839 3.2449894699468514E-49 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 526 13588 15.946110876402383 3.62789822740058E-46 3.2980892976368907E-47 5.199855605900307E-46 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 50 61.72839506172839 4.7436368509167764E-49 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 530 13588 15.825762869788026 5.303385999324956E-46 4.419488332770797E-47 7.601327184583706E-46 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 50 61.72839506172839 3.6286877341962314E-48 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 552 13588 15.195025943818212 4.056872886831387E-45 3.120671451408759E-46 5.814703693639721E-45 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 50 61.72839506172839 5.692363024650894E-48 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 557 13588 15.058625351862933 6.364061861559699E-45 4.5457584725426424E-46 9.121590704279042E-45 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 44 54.32098765432099 3.426398397914222E-47 MEF2C, THRA, SOX4, FOXO1, SOX6, RORA, FOXO3, SRF, TCF7L1, ARNT, GATA2, HAND2, GATA6, GATA4, NFAT5, RARA, RARB, NFATC3, NKX2-5, EGR1, TRP53, RARG, EPAS1, MAFB, RXRB, RXRA, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, MECOM, STAT3, HIF1A, SP1, ETS1, JUN, PBX1, ZFPM2, FOXC1, CLOCK 81 358 13588 20.617697772260154 3.8307134088681E-44 2.5538089392454E-45 5.490549994830618E-44 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 50 61.72839506172839 3.2720534999559846E-45 MEF2C, MEF2A, THRA, TBX20, FOXO1, FOXO3, RORA, GATA2, GATA6, GATA4, RARA, RARB, EGR1, RARG, RXRB, RELA, RXRA, ARNTL, MECOM, HIF1A, JUN, FOXC1, ZFPM2, NFE2L2, CLOCK, SOX4, SOX6, SRF, TCF7L1, ARNT, TCF21, HAND2, NFAT5, NKX2-5, NFATC3, TRP53, EPAS1, MAFB, TBX5, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, STAT3, SP1, ETS1, PBX1, KLF2 81 633 13588 13.25063873773721 3.658155812950791E-42 2.2863473830942444E-43 5.24322371216524E-42 Annotation Cluster 4 Enrichment Score: 24.755532574686416 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005667~transcription factor complex 26 32.098765432098766 2.0562572605711464E-34 IRX4, SOX6, MEIS1, ARNT, TFAM, HAND2, GATA6, NKX2-5, RARG, EPAS1, SMAD7, TBX2, MAFB, CREB1, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1, ARNTL, HIF1A, ETS1, JUN, PBX1, CLOCK 40 234 12504 34.733333333333334 7.196900411999012E-33 7.196900411999012E-33 1.821354796696226E-31 GOTERM_CC_FAT GO:0044451~nucleoplasm part 28 34.5679012345679 4.4438521337343014E-29 IRX4, SOX6, MEIS1, ARNT, TFAM, GATA6, HAND2, NKX2-5, RARG, EPAS1, MAFB, SMAD7, TBX2, SMAD6, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, HIF1A, ETS1, JUN, PBX1, RERE, NCOR2, CLOCK 40 513 12504 17.061988304093568 1.5553482468070056E-27 7.776741234035028E-28 3.9361959005740285E-26 GOTERM_CC_FAT GO:0005654~nucleoplasm 28 34.5679012345679 2.962530966833852E-27 IRX4, SOX6, MEIS1, ARNT, TFAM, GATA6, HAND2, NKX2-5, RARG, EPAS1, MAFB, SMAD7, TBX2, SMAD6, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, HIF1A, ETS1, JUN, PBX1, RERE, NCOR2, CLOCK 40 599 12504 14.612353923205342 1.0368858383918481E-25 3.456286127972827E-26 2.6240977188356286E-24 GOTERM_CC_FAT GO:0031981~nuclear lumen 29 35.80246913580247 3.0184791663830254E-24 IRX4, SOX6, MEIS1, ARNT, TFAM, HAND2, GATA6, NKX2-5, TRP53, RARG, EPAS1, MAFB, TBX2, SMAD7, SMAD6, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, HIF1A, ETS1, JUN, PBX1, RERE, NCOR2, CLOCK 40 883 12504 10.266591166477916 1.0564677082340589E-22 2.6411692705851473E-23 2.6736545148501022E-21 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 29 35.80246913580247 2.813094078252166E-21 IRX4, SOX6, MEIS1, ARNT, TFAM, HAND2, GATA6, NKX2-5, TRP53, RARG, EPAS1, MAFB, TBX2, SMAD7, SMAD6, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, HIF1A, ETS1, JUN, PBX1, RERE, NCOR2, CLOCK 40 1133 12504 8.001235657546337 9.845829273882581E-20 1.969165854776516E-20 2.49173218314093E-18 GOTERM_CC_FAT GO:0043233~organelle lumen 29 35.80246913580247 3.0232071100740895E-21 IRX4, SOX6, MEIS1, ARNT, TFAM, HAND2, GATA6, NKX2-5, TRP53, RARG, EPAS1, MAFB, TBX2, SMAD7, SMAD6, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, HIF1A, ETS1, JUN, PBX1, RERE, NCOR2, CLOCK 40 1136 12504 7.980105633802817 1.0581224885259313E-19 1.763537480876552E-20 2.677842348291642E-18 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 29 35.80246913580247 7.40170361318012E-21 IRX4, SOX6, MEIS1, ARNT, TFAM, HAND2, GATA6, NKX2-5, TRP53, RARG, EPAS1, MAFB, TBX2, SMAD7, SMAD6, CREB1, SMAD5, SMAD4, SMAD3, SMAD2, ARNTL, SMAD1, HIF1A, ETS1, JUN, PBX1, RERE, NCOR2, CLOCK 40 1174 12504 7.7218057921635435 2.590596264613042E-19 3.7008518065900605E-20 6.556148706725966E-18 Annotation Cluster 5 Enrichment Score: 15.858052227571397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 23 28.39506172839506 2.4402534482479366E-18 EGR1, TRP53, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 308 13588 12.52701619368286 2.7282033551411933E-15 1.4358965027058912E-16 3.910325654430372E-15 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 23 28.39506172839506 2.8033591204303142E-18 EGR1, TRP53, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 310 13588 12.446196734368778 3.1341554966410915E-15 1.5670777483205456E-16 4.492175636539146E-15 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 24 29.629629629629626 9.003306419042414E-18 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 372 13588 10.822779769016329 1.0065696576489419E-14 4.575316625677009E-16 1.4427132595737728E-14 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 24 29.629629629629626 3.771243154199917E-17 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 397 13588 10.141244519078272 4.216249846395507E-14 1.8331521071284815E-15 6.043138209906357E-14 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 24 29.629629629629626 4.6986047438785475E-17 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 401 13588 10.0400849727533 5.2530401036562165E-14 2.1887667098567567E-15 7.529166563910855E-14 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 20 24.691358024691358 5.0087397904614904E-17 EGR1, TRP53, RARG, TBX2, JARID2, PRRX1, SMAD3, SOX6, FOXP4, FOXP1, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 231 13588 14.524076746298968 5.599771085735946E-14 2.2399084342943785E-15 8.02613503653486E-14 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 26 32.098765432098766 5.234579674859337E-17 THRA, TBX20, PRRX1, SOX6, TCF7L1, TCF21, BCL6, RARA, RARB, NR2F2, NKX2-5, TRP53, EGR1, RARG, TBX2, JARID2, RELA, SMAD3, FOXP4, FOXP1, HHEX, JUN, HOPX, ZFPM2, ZFPM1, NCOR2 81 506 13588 8.619723808129605 5.852260076492738E-14 2.2508692601895147E-15 8.388026746753955E-14 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 24 29.629629629629626 7.63813549559831E-17 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 410 13588 9.819692863595302 1.241229341530925E-13 4.551914400963142E-15 1.7763568394002505E-13 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 24 29.629629629629626 1.164853676801645E-16 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 418 13588 9.631756158071948 1.241229341530925E-13 4.440892098500626E-15 1.7763568394002505E-13 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 24 29.629629629629626 2.157661906145409E-16 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 430 13588 9.362962962962962 2.48245868306185E-13 8.548717289613705E-15 3.552713678800501E-13 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 24 29.629629629629626 2.638580106660135E-16 EGR1, TRP53, THRA, RARG, TBX2, JARID2, TBX20, PRRX1, SMAD3, SOX6, FOXP4, TCF7L1, FOXP1, TCF21, HHEX, HOPX, BCL6, RARA, ZFPM2, RARB, ZFPM1, NR2F2, NKX2-5, NCOR2 81 434 13588 9.276668373442567 2.48245868306185E-13 8.326672684688674E-15 3.552713678800501E-13 GOTERM_MF_FAT GO:0016564~transcription repressor activity 14 17.28395061728395 3.4848286089328924E-10 THRA, TBX2, JARID2, PRRX1, FOXP4, FOXP1, HHEX, HOPX, RARA, ZFPM2, BCL6, ZFPM1, NKX2-5, NCOR2 81 211 13288 10.884793165993797 2.5090769129043622E-8 2.7878632735678366E-9 3.6272770342904437E-7 Annotation Cluster 6 Enrichment Score: 13.242824718131594 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS ubl conjugation 22 27.160493827160494 6.843055998268038E-15 MEF2C, TRP53, MEF2A, THRA, EPAS1, SMAD7, MAFB, RXRA, RELA, SMAD4, SMAD2, ARNTL, RORA, SOX6, NR3C1, STAT1, TAL1, MEF2D, HIF1A, SP1, ETS1, NFATC4 80 524 17854 9.369942748091603 4.887201754399939E-13 8.149037000748649E-14 7.149836278586008E-12 SP_PIR_KEYWORDS isopeptide bond 17 20.98765432098765 6.57305890692496E-14 MEF2C, TRP53, MEF2A, THRA, SMAD7, MAFB, RXRA, SMAD4, NR3C1, SOX6, RORA, ARNTL, STAT1, MEF2D, HIF1A, SP1, ETS1 80 277 17854 13.696660649819494 4.666489417104458E-12 6.666889262874065E-13 6.821210263296962E-11 UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) 12 14.814814814814813 4.154399212611542E-13 MEF2C, TRP53, HIF1A, SP1, ETS1, MAFB, RXRA, ARNTL, RORA, SOX6, NR3C1, STAT1 79 88 16021 27.6542002301496 1.0676948214438653E-10 3.558986438889633E-11 5.420441873127402E-10 Annotation Cluster 7 Enrichment Score: 12.993197053024064 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048738~cardiac muscle tissue development 14 17.28395061728395 7.218008716266015E-18 RXRB, TBX2, SMAD7, TBX5, RXRA, PROX1, FOXP1, GATA6, GATA4, FOXC1, RARA, ZFPM2, RARB, NKX2-5 81 57 13588 41.202512453974435 8.069733744785405E-15 3.842730354659717E-16 1.1566325078807683E-14 GOTERM_BP_FAT GO:0014706~striated muscle tissue development 16 19.753086419753085 5.983479334560691E-16 MEF2C, SMAD7, TBX2, RXRB, TBX5, RXRA, PROX1, FOXP1, GATA6, GATA4, RARA, ZFPM2, FOXC1, RARB, NR2F2, NKX2-5 81 127 13588 21.134247108000388 6.206146707654625E-13 1.9984014443252818E-14 8.881784197001252E-13 GOTERM_BP_FAT GO:0060537~muscle tissue development 16 19.753086419753085 1.808192093859428E-15 MEF2C, SMAD7, TBX2, RXRB, TBX5, RXRA, PROX1, FOXP1, GATA6, GATA4, RARA, ZFPM2, FOXC1, RARB, NR2F2, NKX2-5 81 136 13588 19.735657225853306 1.98596694644948E-12 6.206146707654625E-14 2.8421709430404007E-12 GOTERM_BP_FAT GO:0035051~cardiac cell differentiation 11 13.580246913580247 2.2959522551539767E-15 GATA6, RXRB, RXRA, TBX5, GATA4, RARA, SOX6, RARB, NKX2-5, PROX1, FOXP1 81 33 13588 55.91769547325103 2.6065816172149425E-12 7.893685705084863E-14 3.7414515929867775E-12 GOTERM_BP_FAT GO:0055007~cardiac muscle cell differentiation 10 12.345679012345679 3.3738088566805143E-14 GATA6, RXRB, RXRA, TBX5, GATA4, RARA, RARB, NKX2-5, PROX1, FOXP1 81 28 13588 59.91181657848325 3.773337198254012E-11 1.0198508704206688E-12 5.4078963529491375E-11 GOTERM_BP_FAT GO:0007517~muscle organ development 16 19.753086419753085 8.47275280924376E-14 MEF2C, SMAD7, TBX2, RXRB, TBX5, RXRA, PROX1, FOXP1, GATA6, GATA4, RARA, ZFPM2, FOXC1, RARB, NR2F2, NKX2-5 81 176 13588 15.250280583613916 9.470579875880958E-11 2.428390821762605E-12 1.357469692209179E-10 GOTERM_BP_FAT GO:0042692~muscle cell differentiation 13 16.049382716049383 3.4450833593208634E-12 MEF2C, RXRB, TBX2, TBX5, RXRA, SOX6, PROX1, FOXP1, GATA6, GATA4, RARA, RARB, NKX2-5 81 117 13588 18.63923182441701 3.851658769704613E-9 8.95734597605724E-11 5.520572887718345E-9 GOTERM_BP_FAT GO:0051146~striated muscle cell differentiation 10 12.345679012345679 2.3281922544123037E-9 GATA6, RXRB, RXRA, TBX5, GATA4, RARA, RARB, NKX2-5, PROX1, FOXP1 81 89 13588 18.848661395477876 2.6029156131590625E-6 4.732579894639599E-8 3.730755893105453E-6 GOTERM_BP_FAT GO:0055012~ventricular cardiac muscle cell differentiation 6 7.4074074074074066 2.800814341943078E-9 RXRB, RXRA, RARA, RARB, NKX2-5, PROX1 81 11 13588 91.5016835016835 3.1313055542936397E-6 5.493526966660056E-8 4.488097749000275E-6 Annotation Cluster 8 Enrichment Score: 11.551495737968818 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001944~vasculature development 19 23.456790123456788 4.058272623427809E-15 MEF2C, EPAS1, SMAD7, TBX20, SMAD5, PRRX1, FOXO1, MEIS1, SRF, PROX1, TCF21, HIF1A, HEY1, HAND2, ZFPM2, FOXC1, VEZF1, NR2F2, NKX2-5 81 250 13588 12.749234567901233 4.5925485636644225E-12 1.3511414209688155E-13 6.583622536027178E-12 GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 17 20.98765432098765 2.6694910952661568E-14 MEF2C, EPAS1, SMAD7, TBX20, SMAD5, PRRX1, MEIS1, SRF, PROX1, HIF1A, HEY1, HAND2, ZFPM2, FOXC1, VEZF1, NR2F2, NKX2-5 81 198 13588 14.403042773413143 2.97895041967422E-11 8.274492202531292E-13 4.269917752708352E-11 GOTERM_BP_FAT GO:0001568~blood vessel development 18 22.22222222222222 4.4586962258248297E-14 MEF2C, EPAS1, SMAD7, TBX20, SMAD5, PRRX1, FOXO1, MEIS1, SRF, PROX1, HIF1A, HEY1, HAND2, ZFPM2, FOXC1, VEZF1, NR2F2, NKX2-5 81 244 13588 12.375227686703097 4.9897419529543185E-11 1.3130607712241726E-12 7.152056724635258E-11 GOTERM_BP_FAT GO:0001525~angiogenesis 8 9.876543209876543 1.288366633159682E-5 HIF1A, EPAS1, HAND2, TBX20, SMAD5, VEZF1, MEIS1, SRF 81 133 13588 10.09041121321823 0.014300789975655426 1.6366878374907134E-4 0.02064312434728599 Annotation Cluster 9 Enrichment Score: 11.518427777395726 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001701~in utero embryonic development 17 20.98765432098765 2.7605290917365295E-12 TRP53, EPAS1, SMAD3, SMAD2, MECOM, SRF, ARNT, GATA2, HIF1A, SP1, GATA6, HAND2, GATA4, HOPX, FOXC1, ZFPM2, NCOR2 81 267 13588 10.680908124104128 3.086316757716645E-9 7.527600764944964E-11 4.4236059260072125E-9 GOTERM_BP_FAT GO:0043009~chordate embryonic development 20 24.691358024691358 2.9227687814117582E-12 TRP53, EPAS1, PRRX1, SMAD3, SMAD2, MECOM, SRF, ARNT, GATA2, HIF1A, SP1, GATA6, HAND2, GATA4, HOPX, PBX1, FOXC1, ZFPM2, NKX2-5, NCOR2 81 421 13588 7.9692677634086975 3.267660364514313E-9 7.780143196356448E-11 4.683531340532454E-9 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 20 24.691358024691358 3.450880175442971E-12 TRP53, EPAS1, PRRX1, SMAD3, SMAD2, MECOM, SRF, ARNT, GATA2, HIF1A, SP1, GATA6, HAND2, GATA4, HOPX, PBX1, FOXC1, ZFPM2, NKX2-5, NCOR2 81 425 13588 7.894262890341321 3.858113162280574E-9 8.76844152841727E-11 5.529821045513472E-9 Annotation Cluster 10 Enrichment Score: 10.780093479630256 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035295~tube development 23 28.39506172839506 8.72801015006591E-20 EPAS1, TBX5, TBX20, SMAD4, SMAD3, SMAD2, NR3C1, SRF, FOXP1, TCF21, HHEX, HIF1A, SP1, GATA6, HAND2, GATA4, HOPX, PBX1, FOXC1, ZFPM2, RARA, RARB, NKX2-5 81 264 13588 14.614852225963338 9.757915347773687E-17 5.421064082096493E-18 1.3985990687334444E-16 GOTERM_BP_FAT GO:0060541~respiratory system development 11 13.580246913580247 2.6664128245586096E-9 HHEX, TCF21, RARG, SP1, EPAS1, GATA6, TBX5, HOPX, ZFPM2, SMAD2, FOXP1 81 124 13588 14.881322182397449 2.981045147398831E-6 5.323302698645449E-8 4.2727293148026035E-6 GOTERM_BP_FAT GO:0030324~lung development 10 12.345679012345679 1.668133721665919E-8 HHEX, TCF21, SP1, EPAS1, GATA6, TBX5, HOPX, ZFPM2, SMAD2, FOXP1 81 111 13588 15.112890668446223 1.8649561240424717E-5 2.9140206914135547E-7 2.673060566227292E-5 GOTERM_BP_FAT GO:0030323~respiratory tube development 10 12.345679012345679 1.952327121872157E-8 HHEX, TCF21, SP1, EPAS1, GATA6, TBX5, HOPX, ZFPM2, SMAD2, FOXP1 81 113 13588 14.845405877854256 2.1826779231570725E-5 3.3580021185919406E-7 3.128459348245016E-5 Annotation Cluster 11 Enrichment Score: 9.89347769671347 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002520~immune system development 17 20.98765432098765 1.2541595866466371E-11 TRP53, EGR1, EPAS1, JARID2, SMAD5, SOX4, SMAD3, SOX6, MEIS1, FOXP1, TAL1, TCF21, HIF1A, SP1, BCL6, PBX1, NKX2-5 81 295 13588 9.66712701401967 1.4021547145581792E-8 2.983308045045874E-10 2.0097046249389905E-8 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 16 19.753086419753085 7.413552444066614E-11 TRP53, EGR1, EPAS1, JARID2, SMAD5, SOX4, SOX6, MEIS1, FOXP1, TAL1, TCF21, HIF1A, SP1, BCL6, PBX1, NKX2-5 81 281 13588 9.551777162690566 8.28834582078386E-8 1.6576692241088153E-9 1.1879661698799282E-7 GOTERM_BP_FAT GO:0030097~hemopoiesis 14 17.28395061728395 2.244852153395779E-9 TRP53, EGR1, EPAS1, SMAD5, SOX4, SOX6, MEIS1, FOXP1, TAL1, HIF1A, SP1, BCL6, PBX1, NKX2-5 81 251 13588 9.356745856081844 2.509741605205562E-6 4.6476753667867854E-8 3.5972095302483353E-6 Annotation Cluster 12 Enrichment Score: 8.872800935674444 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007389~pattern specification process 17 20.98765432098765 7.059205810765529E-12 TRP53, RARG, MAFB, TBX5, SMAD5, TBX20, SMAD4, SMAD3, SMAD2, SMAD1, SRF, TCF7L1, HHEX, GATA4, PBX1, FOXC1, NR2F2 81 284 13588 10.041557989914796 7.892232645190234E-9 1.7538293040075814E-10 1.1311918068912519E-8 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 18 22.22222222222222 2.2790620642882868E-11 TRP53, RARG, MAFB, TBX5, PRRX1, SMAD4, SMAD3, SMAD2, SMAD1, MECOM, FOXP4, PROX1, HHEX, SP1, GATA4, PBX1, FOXC1, RARB 81 359 13588 8.411018260600432 2.547995558987992E-8 5.308323780539581E-10 3.6520342305834674E-8 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 15 18.51851851851852 9.44313992046462E-11 RARG, SMAD7, TBX5, RXRA, SMAD4, SMAD3, SMAD2, SMAD1, NR3C1, PROX1, TCF7L1, HHEX, TCF21, PBX1, FOXC1 81 238 13588 10.572673513849983 1.0557424556800754E-7 2.0700833269771124E-9 1.5131925712452698E-7 GOTERM_BP_FAT GO:0003002~regionalization 13 16.049382716049383 4.023129122278795E-9 TRP53, HHEX, RARG, MAFB, GATA4, TBX20, SMAD4, SMAD3, PBX1, FOXC1, SMAD2, NR2F2, TCF7L1 81 214 13588 10.190608053536401 4.497848298146145E-6 7.754927999759076E-8 6.4467667093559555E-6 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 11 13.580246913580247 2.0445183436564888E-8 TRP53, HHEX, RARG, GATA4, SMAD4, SMAD3, FOXC1, PBX1, SMAD2, NR2F2, TCF7L1 81 153 13588 12.06067941579924 2.2857454078595296E-5 3.463289599547892E-7 3.2761889168231306E-5 GOTERM_BP_FAT GO:0007369~gastrulation 7 8.641975308641975 4.638856970562149E-6 TRP53, GATA4, SMAD4, SMAD3, FOXC1, SMAD2, SMAD1 81 74 13588 15.868535201868534 0.005172828725521272 6.482607522706463E-5 0.007433166144343861 Annotation Cluster 13 Enrichment Score: 7.820406391671985 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048729~tissue morphogenesis 15 18.51851851851852 9.44313992046462E-11 RARG, SMAD7, TBX5, RXRA, SMAD4, SMAD3, SMAD2, SMAD1, NR3C1, PROX1, TCF7L1, HHEX, TCF21, PBX1, FOXC1 81 238 13588 10.572673513849983 1.0557424556800754E-7 2.0700833269771124E-9 1.5131925712452698E-7 GOTERM_BP_FAT GO:0060429~epithelium development 15 18.51851851851852 5.243799466600923E-10 RARG, TBX5, RXRA, SMAD4, SMAD3, SMAD2, NR3C1, MECOM, PROX1, HHEX, TCF21, GATA6, JUN, PBX1, VEZF1 81 271 13588 9.285226185595189 5.862566503367361E-7 1.1061449423088732E-8 8.402801343621036E-7 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 8 9.876543209876543 6.982618668428036E-5 HHEX, TCF21, RARG, TBX5, SMAD4, PBX1, NR3C1, PROX1 81 173 13588 7.757368158138871 0.07509884103689823 7.726558263940753E-4 0.11183262669148819 Annotation Cluster 14 Enrichment Score: 7.682510138786171 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013088:Zinc finger, NHR/GATA-type 12 14.814814814814813 4.887174714929882E-16 NR1H2, GATA2, THRA, RARG, GATA6, RXRB, RXRA, GATA4, RARA, RORA, NR3C1, NR2F2 81 53 17763 49.65199161425576 5.1514348342607263E-14 5.1514348342607263E-14 5.10702591327572E-13 UP_SEQ_FEATURE region of interest:Modulating 8 9.876543209876543 3.0696242295723373E-13 THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB 79 15 16021 108.15864978902954 7.889300324137594E-11 3.944644610953674E-11 4.0052405836377147E-10 INTERPRO IPR001628:Zinc finger, nuclear hormone receptor-type 10 12.345679012345679 5.690395890236649E-13 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 81 47 17763 46.658786446020486 6.600275881396556E-11 2.200095661208934E-11 6.49147402498329E-10 INTERPRO IPR001723:Steroid hormone receptor 10 12.345679012345679 6.97814374159832E-13 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 81 48 17763 45.68672839506173 8.094191983332166E-11 2.0235479958330416E-11 7.960743175772222E-10 INTERPRO IPR008946:Nuclear hormone receptor, ligand-binding 10 12.345679012345679 8.517774963873532E-13 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 81 49 17763 44.75434618291761 9.880452012112073E-11 1.976085961530316E-11 9.717671112241533E-10 INTERPRO IPR000536:Nuclear hormone receptor, ligand-binding, core 10 12.345679012345679 8.517774963873532E-13 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 81 49 17763 44.75434618291761 9.880452012112073E-11 1.976085961530316E-11 9.717671112241533E-10 UP_SEQ_FEATURE DNA-binding region:Nuclear receptor 10 12.345679012345679 9.100526018262791E-13 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 79 46 16021 44.086406164006604 2.338828020143069E-10 4.677658260732187E-11 1.1873724226063587E-9 UP_SEQ_FEATURE zinc finger region:NR C4-type 10 12.345679012345679 9.100526018262791E-13 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 79 46 16021 44.086406164006604 2.338828020143069E-10 4.677658260732187E-11 1.1873724226063587E-9 GOTERM_MF_FAT GO:0003707~steroid hormone receptor activity 10 12.345679012345679 1.1065615444469836E-11 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 81 49 13288 33.47946586041824 7.967226878236033E-10 1.3278711463726722E-10 1.1517919951131717E-8 GOTERM_MF_FAT GO:0004879~ligand-dependent nuclear receptor activity 10 12.345679012345679 3.9449222415141445E-11 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 81 56 13288 29.29453262786596 2.8403439600310776E-9 3.550429950038847E-10 4.1061776201445355E-8 UP_SEQ_FEATURE region of interest:Ligand-binding 8 9.876543209876543 7.051727251283888E-11 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, RARB 79 29 16021 55.94412920122217 1.8122935374620397E-8 3.0204891920959653E-9 9.200658013241991E-8 SMART SM00399:ZnF_C4 10 12.345679012345679 1.582490092723909E-10 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 79 47 9131 24.591974144896312 5.2222159929726786E-9 2.6111079964863393E-9 1.3812784249722654E-7 SMART SM00430:HOLI 10 12.345679012345679 2.353497057470556E-10 NR1H2, THRA, RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB, NR2F2 79 49 9131 23.58822009816585 7.766541409992556E-9 2.588847136664185E-9 2.0542536560697044E-7 UP_SEQ_FEATURE region of interest:Hinge 7 8.641975308641975 5.605936425207258E-10 RARG, RXRB, RXRA, RARA, RORA, NR3C1, RARB 79 21 16021 67.59915611814345 1.440725660994957E-7 1.8009071900415563E-8 7.314281069703554E-7 SP_PIR_KEYWORDS zinc finger 7 8.641975308641975 4.551905141337574E-7 EGR1, THRA, RXRB, RXRA, RORA, NR3C1, RARB 80 66 17854 23.670075757575756 3.231801162340009E-5 2.154566603018715E-6 4.724491556529209E-4 GOTERM_MF_FAT GO:0003708~retinoic acid receptor activity 5 6.172839506172839 5.812113369021721E-7 RARG, RXRB, RXRA, RARA, RARB 81 12 13288 68.35390946502058 4.184635283821514E-5 2.7898113365010246E-6 6.049676286479233E-4 PIR_SUPERFAMILY PIRSF002534:retinoic X receptor-like nuclear receptor 4 4.938271604938271 1.075501244637896E-5 RXRB, RXRA, RARB, NR2F2 35 11 8136 84.52987012987012 4.3011028731776424E-4 2.1507827299060978E-4 0.009839365282726664 GOTERM_BP_FAT GO:0001655~urogenital system development 8 9.876543209876543 2.362039991356164E-5 TCF21, RARG, RXRA, SMAD4, FOXC1, PBX1, RARA, RARB 81 146 13588 9.191949940808387 0.02606227912173642 2.901548088981576E-4 0.03784322841486887 PIR_SUPERFAMILY PIRSF036753:retinoic acid receptor 3 3.7037037037037033 5.0723017117916577E-5 RARG, RARA, RARB 35 3 8136 232.45714285714286 0.0020269151703841137 6.760953920916801E-4 0.046397066372361184 INTERPRO IPR003078:Retinoic acid receptor 3 3.7037037037037033 5.991792639499869E-5 RARG, RARA, RARB 81 3 17763 219.29629629629628 0.006926587539443196 3.8607477057606143E-4 0.06833802109852405 GOTERM_BP_FAT GO:0030522~intracellular receptor-mediated signaling pathway 4 4.938271604938271 8.618690647619774E-4 RARG, RXRB, RXRA, NR3C1 81 32 13588 20.969135802469133 0.6186299397733753 0.007276315832382085 1.372175578941226 GOTERM_BP_FAT GO:0048384~retinoic acid receptor signaling pathway 3 3.7037037037037033 0.001819019353540469 RARG, RXRB, RXRA 81 11 13588 45.75084175084175 0.8693868685490683 0.013845149107665655 2.875350170040525 GOTERM_MF_FAT GO:0005496~steroid binding 3 3.7037037037037033 0.02522205626955332 RXRB, RXRA, NR3C1 81 41 13288 12.003613369467027 0.8410685090143433 0.07685483764211876 23.348269685463674 BIOCARTA m_nuclearRsPathway:Nuclear Receptors in Lipid Metabolism and Toxicity 3 3.7037037037037033 0.290881001644391 RARG, RARA, RARB 39 33 1171 2.72960372960373 0.9999999999999999 0.8703990730599094 97.90109606368725 SP_PIR_KEYWORDS receptor 12 14.814814814814813 0.5373774666688018 NR1H2, THRA, RARG, RXRB, RXRA, RARA, ARNTL, RORA, NR3C1, RARB, NR2F2, ARNT 80 2465 17854 1.0864503042596347 1.0 0.8682743264216544 99.96647795866554 GOTERM_MF_FAT GO:0008289~lipid binding 3 3.7037037037037033 0.6189734777489277 RXRB, RXRA, NR3C1 81 345 13288 1.4265163714439075 1.0 0.893650690640417 99.9956522878166 Annotation Cluster 15 Enrichment Score: 6.242106275883308 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003702~RNA polymerase II transcription factor activity 10 12.345679012345679 9.550539719555105E-9 IRX4, GATA6, RELA, TBX5, GATA4, FOXC1, SMAD1, PROX1, MEIS1, FOXP1 81 102 13288 16.083272815298958 6.87638624707887E-7 6.251262174572503E-8 9.940932876872921E-6 GOTERM_MF_FAT GO:0003705~RNA polymerase II transcription factor activity, enhancer binding 7 8.641975308641975 2.0828452454379715E-8 GATA6, RELA, GATA4, FOXC1, PROX1, MEIS1, FOXP1 81 30 13288 38.27818930041152 1.4996474644313196E-6 1.1535757715730455E-7 2.1679846695654703E-5 GOTERM_BP_FAT GO:0046620~regulation of organ growth 4 4.938271604938271 9.440527333530815E-4 TBX5, GATA4, FOXC1, PROX1 81 33 13588 20.333707444818558 0.6521380141800395 0.007849252391927686 1.50209351194317 Annotation Cluster 16 Enrichment Score: 5.447603273199084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE DNA-binding region:Basic motif 14 17.28395061728395 4.615799131468615E-13 EPAS1, MAFB, CREB1, ARNTL, ATF2, ARNT, TAL1, TCF21, HIF1A, HEY1, HAND2, JUN, NFE2L2, CLOCK 79 154 16021 18.436133486766398 1.18639098545259E-10 2.965983014746598E-11 6.023070930893937E-10 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 9 11.11111111111111 3.5947931060513906E-8 TCF21, TAL1, HIF1A, HEY1, EPAS1, HAND2, ARNTL, CLOCK, ARNT 81 111 17763 17.78078078078078 4.169951385524229E-6 5.212448741520603E-7 4.101237007780867E-5 UP_SEQ_FEATURE domain:Helix-loop-helix motif 9 11.11111111111111 5.5937136760169186E-8 TCF21, TAL1, HIF1A, HEY1, EPAS1, HAND2, ARNTL, CLOCK, ARNT 79 109 16021 16.744745093485076 1.4375741230643335E-5 1.4375834229696238E-6 7.298330656491103E-5 INTERPRO IPR013655:PAS fold-3 5 6.172839506172839 1.1124146407084673E-6 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 81 18 17763 60.9156378600823 1.2903184477386365E-4 1.0753289691134427E-5 0.0012691274284493126 UP_SEQ_FEATURE domain:PAS 2 5 6.172839506172839 1.9060892552816829E-6 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 79 19 16021 53.36775483011326 4.897454410132118E-4 3.4989773949334335E-5 0.002486919317401526 UP_SEQ_FEATURE domain:PAS 1 5 6.172839506172839 1.9060892552816829E-6 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 79 19 16021 53.36775483011326 4.897454410132118E-4 3.4989773949334335E-5 0.002486919317401526 INTERPRO IPR011598:Helix-loop-helix DNA-binding 7 8.641975308641975 2.2731896797556763E-6 TCF21, TAL1, HEY1, HAND2, ARNTL, CLOCK, ARNT 81 85 17763 18.059694989106752 2.636555393237261E-4 2.0283663711095912E-5 0.0025934124188164986 INTERPRO IPR001067:Nuclear translocator 4 4.938271604938271 3.039118472482153E-6 EPAS1, ARNTL, CLOCK, ARNT 81 7 17763 125.3121693121693 3.5247614418854045E-4 2.5180988561190887E-5 0.0034672232770871503 SMART SM00353:HLH 9 11.11111111111111 4.280352659603114E-6 TCF21, TAL1, HIF1A, HEY1, EPAS1, HAND2, ARNTL, CLOCK, ARNT 79 111 9131 9.37153609305508 1.4124196448705995E-4 2.8249988976103424E-5 0.003736050305602756 UP_SEQ_FEATURE domain:PAC 5 6.172839506172839 5.129826921689382E-6 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 79 24 16021 42.24947257383966 0.0013175002338836617 8.788739770171361E-5 0.006692875425273748 INTERPRO IPR001610:PAC motif 5 6.172839506172839 5.28800109315077E-6 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 81 26 17763 42.17236467236467 6.132216513611288E-4 4.0893147096432436E-5 0.006032823681145771 INTERPRO IPR000014:PAS 5 6.172839506172839 1.2461061439443454E-5 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 81 32 17763 34.26504629629629 0.0014444479126265453 9.033917749456943E-5 0.014215689233754158 SMART SM00086:PAC 5 6.172839506172839 6.386448843355776E-5 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 79 26 9131 22.22736124634859 0.0021053759995359744 2.634147276562304E-4 0.05573045739244442 SMART SM00091:PAS 5 6.172839506172839 1.4776073478349645E-4 HIF1A, EPAS1, ARNTL, CLOCK, ARNT 79 32 9131 18.05973101265823 0.004864593881994894 5.416826293761501E-4 0.1288995568281881 GOTERM_BP_FAT GO:0001890~placenta development 6 7.4074074074074066 1.5794934501515767E-4 GATA2, HIF1A, SP1, EPAS1, PBRM1, ARNT 81 87 13588 11.569178373776074 0.16188613875718705 0.0016188837433513958 0.25280204928354033 INTERPRO IPR013767:PAS fold 4 4.938271604938271 2.38002865232378E-4 HIF1A, ARNTL, CLOCK, ARNT 81 27 17763 32.48834019204389 0.027233902023515166 0.001199784826300232 0.27119729702490547 GOTERM_BP_FAT GO:0001892~embryonic placenta development 5 6.172839506172839 4.5058901068739606E-4 GATA2, HIF1A, SP1, EPAS1, ARNT 81 61 13588 13.750252985225663 0.3958133116170355 0.004088141372402099 0.7195966956264677 KEGG_PATHWAY mmu05211:Renal cell carcinoma 5 6.172839506172839 0.001463712062430068 HIF1A, EPAS1, ETS1, JUN, ARNT 42 70 5738 9.758503401360544 0.07334021332109164 0.007587943635825045 1.413054238646505 Annotation Cluster 17 Enrichment Score: 5.278966262921614 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030097~hemopoiesis 14 17.28395061728395 2.244852153395779E-9 TRP53, EGR1, EPAS1, SMAD5, SOX4, SOX6, MEIS1, FOXP1, TAL1, HIF1A, SP1, BCL6, PBX1, NKX2-5 81 251 13588 9.356745856081844 2.509741605205562E-6 4.6476753667867854E-8 3.5972095302483353E-6 GOTERM_BP_FAT GO:0042592~homeostatic process 15 18.51851851851852 6.883956637467385E-6 TRP53, EPAS1, SMAD7, SMAD5, FOXO3, SMAD1, SOX6, MECOM, SRF, STAT3, TAL1, HIF1A, SP1, BCL6, NCOR2 81 584 13588 4.308726534753932 0.0076667494041948725 9.161830292059303E-5 0.011030460899841277 GOTERM_BP_FAT GO:0030218~erythrocyte differentiation 6 7.4074074074074066 8.754697378503364E-6 TAL1, SP1, EPAS1, SMAD5, BCL6, SOX6 81 48 13588 20.969135802469136 0.00974004995137323 1.1514389412470294E-4 0.01402783241359895 GOTERM_BP_FAT GO:0034101~erythrocyte homeostasis 6 7.4074074074074066 1.1845809301145751E-5 TAL1, SP1, EPAS1, SMAD5, BCL6, SOX6 81 51 13588 19.735657225853302 0.013156381403382822 1.5221477323568156E-4 0.018980344149410744 GOTERM_BP_FAT GO:0048872~homeostasis of number of cells 7 8.641975308641975 5.2742645740812205E-5 TAL1, SP1, EPAS1, SMAD5, BCL6, SOX6, MECOM 81 113 13588 10.391784114497979 0.057262906317562035 6.140596486958749E-4 0.08448271075207625 GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 6 7.4074074074074066 2.507314232424506E-4 TAL1, SP1, EPAS1, SMAD5, BCL6, SOX6 81 96 13588 10.484567901234568 0.24448291192505467 0.0024779237976005897 0.40102268556371223 Annotation Cluster 18 Enrichment Score: 5.108360124316073 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0055012~ventricular cardiac muscle cell differentiation 6 7.4074074074074066 2.800814341943078E-9 RXRB, RXRA, RARA, RARB, NKX2-5, PROX1 81 11 13588 91.5016835016835 3.1313055542936397E-6 5.493526966660056E-8 4.488097749000275E-6 GOTERM_MF_FAT GO:0003708~retinoic acid receptor activity 5 6.172839506172839 5.812113369021721E-7 RARG, RXRB, RXRA, RARA, RARB 81 12 13288 68.35390946502058 4.184635283821514E-5 2.7898113365010246E-6 6.049676286479233E-4 PIR_SUPERFAMILY PIRSF002534:retinoic X receptor-like nuclear receptor 4 4.938271604938271 1.075501244637896E-5 RXRB, RXRA, RARB, NR2F2 35 11 8136 84.52987012987012 4.3011028731776424E-4 2.1507827299060978E-4 0.009839365282726664 KEGG_PATHWAY mmu05223:Non-small cell lung cancer 5 6.172839506172839 5.482294696887789E-4 TRP53, RXRB, RXRA, FOXO3, RARB 42 54 5738 12.649911816578483 0.02811301292757251 0.004065392359361875 0.5313697257960048 KEGG_PATHWAY mmu05222:Small cell lung cancer 5 6.172839506172839 0.0029923175900851725 TRP53, RXRB, RXRA, RELA, RARB 42 85 5738 8.03641456582633 0.1442985895172516 0.011915653665230397 2.8696104826707924 Annotation Cluster 19 Enrichment Score: 5.054348264039408 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013019:MAD homology, MH1 7 8.641975308641975 1.9163740224864636E-13 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 8 17763 191.88425925925924 2.2228441309835034E-11 1.1114220654917517E-11 2.1862511800918583E-10 INTERPRO IPR013790:Dwarfin 7 8.641975308641975 1.9163740224864636E-13 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 8 17763 191.88425925925924 2.2228441309835034E-11 1.1114220654917517E-11 2.1862511800918583E-10 INTERPRO IPR001132:SMAD domain, Dwarfin-type 7 8.641975308641975 1.9163740224864636E-13 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 8 17763 191.88425925925924 2.2228441309835034E-11 1.1114220654917517E-11 2.1862511800918583E-10 UP_SEQ_FEATURE domain:MH1 7 8.641975308641975 3.0420215579805317E-13 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 79 8 16021 177.4477848101266 7.817968494805427E-11 7.817968494805427E-11 3.9690473130349346E-10 UP_SEQ_FEATURE domain:MH2 7 8.641975308641975 3.0420215579805317E-13 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 79 8 16021 177.4477848101266 7.817968494805427E-11 7.817968494805427E-11 3.9690473130349346E-10 INTERPRO IPR003619:MAD homology 1, Dwarfin-type 7 8.641975308641975 6.2343619371380976E-12 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 12 17763 127.92283950617283 7.231841792076921E-10 1.2053069653461534E-10 7.112654909491312E-9 SMART SM00524:DWB 7 8.641975308641975 8.828347681962758E-12 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 79 8 9131 101.13449367088609 2.913366214940538E-10 2.913366214940538E-10 7.705869276009025E-9 INTERPRO IPR017855:SMAD domain-like 7 8.641975308641975 5.326369859066518E-11 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 16 17763 95.94212962962962 6.178592304451058E-9 8.826560593533372E-10 6.076766867479932E-8 SMART SM00523:DWA 7 8.641975308641975 2.835365970980082E-10 SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 79 12 9131 67.42299578059071 9.356709074204161E-9 2.339177296306616E-9 2.4748536553431677E-7 PIR_SUPERFAMILY PIRSF037286:Smad protein 5 6.172839506172839 3.790575154633647E-9 SMAD7, SMAD6, SMAD5, SMAD4, SMAD1 35 6 8136 193.7142857142857 1.5162299626947373E-7 1.5162299626947373E-7 3.468009723839316E-6 GOTERM_BP_FAT GO:0007179~transforming growth factor beta receptor signaling pathway 8 9.876543209876543 1.1379273730867097E-8 TRP53, SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 48 13588 27.958847736625515 1.2721947195148964E-5 2.0519398091778385E-7 1.8234442933362516E-5 GOTERM_BP_FAT GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway 8 9.876543209876543 3.5448660896356665E-7 TRP53, SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 81 78 13588 17.205444761000315 3.9623757620510514E-4 5.743695085436151E-6 5.680370581573335E-4 KEGG_PATHWAY mmu04350:TGF-beta signaling pathway 8 9.876543209876543 2.1373152426316556E-6 SP1, SMAD7, SMAD6, SMAD5, SMAD4, SMAD3, SMAD2, SMAD1 42 87 5738 12.562671045429665 1.1113433551268592E-4 3.704615090460717E-5 0.002076520926430625 GOTERM_BP_FAT GO:0001503~ossification 8 9.876543209876543 2.865994619715948E-6 MEF2C, MEF2D, THRA, SP1, SMAD5, SMAD3, FOXC1, SMAD1 81 106 13588 12.66061029583042 0.0031990586490596717 4.27215750936627E-5 0.004592445516371502 GOTERM_BP_FAT GO:0007167~enzyme linked receptor protein signaling pathway 11 13.580246913580247 4.337923652649727E-6 TRP53, SMAD7, SMAD6, SMAD5, SMAD4, FOXO1, SMAD3, FOXC1, SMAD2, SMAD1, STAT3 81 273 13588 6.759281870392981 0.004838067826978043 6.298255109615791E-5 0.006950975278852134 GOTERM_BP_FAT GO:0007369~gastrulation 7 8.641975308641975 4.638856970562149E-6 TRP53, GATA4, SMAD4, SMAD3, FOXC1, SMAD2, SMAD1 81 74 13588 15.868535201868534 0.005172828725521272 6.482607522706463E-5 0.007433166144343861 KEGG_PATHWAY mmu05212:Pancreatic cancer 7 8.641975308641975 1.0045038492706153E-5 TRP53, RELA, SMAD4, SMAD3, SMAD2, STAT1, STAT3 42 72 5738 13.282407407407407 5.222082269052963E-4 1.305776302762407E-4 0.009758978663731988 GOTERM_BP_FAT GO:0009880~embryonic pattern specification 5 6.172839506172839 5.0768451030696155E-5 SMAD5, SMAD3, SMAD2, SMAD1, TCF7L1 81 35 13588 23.964726631393297 0.05517973853598257 5.973012191683447E-4 0.08132166876323454 GOTERM_BP_FAT GO:0048332~mesoderm morphogenesis 5 6.172839506172839 7.061851833470229E-5 SMAD3, FOXC1, SMAD2, SMAD1, TCF7L1 81 38 13588 22.072774528914877 0.07591783797074492 7.662527962198906E-4 0.11310094068168741 GOTERM_BP_FAT GO:0001649~osteoblast differentiation 5 6.172839506172839 1.6392186270301697E-4 MEF2C, MEF2D, SMAD5, SMAD3, SMAD1 81 47 13588 17.846073023377986 0.1674647075430057 0.001664791464617843 0.26234945229027806 GOTERM_BP_FAT GO:0035282~segmentation 5 6.172839506172839 2.817113317761614E-4 TRP53, MAFB, SMAD3, FOXC1, TCF7L1 81 54 13588 15.532693187014175 0.2702094035815793 0.002711813271719765 0.45046750708896965 KEGG_PATHWAY mmu05210:Colorectal cancer 6 7.4074074074074066 3.29795501021138E-4 TRP53, JUN, SMAD4, SMAD3, SMAD2, TCF7L1 42 86 5738 9.53156146179402 0.017005933106572724 0.0028546169050690517 0.319957590710207 GOTERM_BP_FAT GO:0007498~mesoderm development 5 6.172839506172839 3.964880350102431E-4 SMAD3, FOXC1, SMAD2, SMAD1, TCF7L1 81 59 13588 14.21636325591128 0.3581248873001557 0.0037187951720122348 0.6334539031403463 GOTERM_BP_FAT GO:0040007~growth 7 8.641975308641975 9.54851939896638E-4 TRP53, RXRB, RXRA, SMAD3, FOXC1, SMAD2, FOXO3 81 193 13588 6.084308833877055 0.6563166217038328 0.007880153857570127 1.5191532266838115 GOTERM_MF_FAT GO:0043566~structure-specific DNA binding 5 6.172839506172839 0.0011249156158972813 TRP53, SP1, SMAD3, BCL6, SMAD2 81 76 13288 10.79272254710851 0.07784274758398402 0.004755685991828296 1.164721409648195 GOTERM_MF_FAT GO:0003690~double-stranded DNA binding 4 4.938271604938271 0.001197063616788293 TRP53, SP1, SMAD3, SMAD2 81 35 13288 18.748500881834214 0.08262615598721323 0.004779663558667324 1.2390022474667362 GOTERM_BP_FAT GO:0048340~paraxial mesoderm morphogenesis 3 3.7037037037037033 0.0011997681418093517 SMAD3, FOXC1, SMAD2 81 9 13588 55.91769547325103 0.7387156694901712 0.009748855472083595 1.9053090160397246 GOTERM_BP_FAT GO:0001707~mesoderm formation 4 4.938271604938271 0.0012198587878373393 SMAD3, FOXC1, SMAD2, SMAD1 81 36 13588 18.63923182441701 0.7445259972223087 0.009839924700087543 1.9369225568059867 GOTERM_BP_FAT GO:0001704~formation of primary germ layer 4 4.938271604938271 0.0016596902869470513 SMAD3, FOXC1, SMAD2, SMAD1 81 40 13588 16.775308641975307 0.84387139999561 0.01281355424975017 2.6266282793299123 GOTERM_BP_FAT GO:0051098~regulation of binding 5 6.172839506172839 0.001939530627245218 THRA, RELA, SMAD4, SMAD3, SMAD2 81 90 13588 9.319615912208505 0.885879548778184 0.01465683887714142 3.0630794464355904 KEGG_PATHWAY mmu05220:Chronic myeloid leukemia 5 6.172839506172839 0.001985845001261015 TRP53, RELA, SMAD4, SMAD3, MECOM 42 76 5738 8.988095238095237 0.09820369386057626 0.00935295096546751 1.912765346159051 GOTERM_BP_FAT GO:0048339~paraxial mesoderm development 3 3.7037037037037033 0.002975370839051667 SMAD3, FOXC1, SMAD2 81 14 13588 35.94708994708995 0.964257798343105 0.02182081021727189 4.662712552573812 GOTERM_BP_FAT GO:0030278~regulation of ossification 4 4.938271604938271 0.00372527439696164 SMAD5, SMAD3, PBX1, SMAD1 81 53 13588 12.66061029583042 0.9845883831514284 0.026393101725874057 5.805296619899614 GOTERM_MF_FAT GO:0005518~collagen binding 3 3.7037037037037033 0.004066642154969643 SMAD7, SMAD4, SMAD3 81 16 13288 30.759259259259256 0.2542726342058804 0.015323238912082093 4.152809535085544 GOTERM_BP_FAT GO:0045667~regulation of osteoblast differentiation 3 3.7037037037037033 0.010151921706608861 SMAD5, SMAD3, SMAD1 81 26 13588 19.356125356125354 0.9999888920863079 0.06527423046529646 15.084064254483643 BIOCARTA m_tgfbPathway:TGF beta signaling pathway 4 4.938271604938271 0.013191180207384244 SMAD7, SMAD4, SMAD3, SMAD2 39 16 1171 7.506410256410256 0.7584909556190347 0.5085643029032534 13.865788697866455 GOTERM_BP_FAT GO:0017015~regulation of transforming growth factor beta receptor signaling pathway 3 3.7037037037037033 0.013383379081777027 TRP53, SMAD7, SMAD3 81 30 13588 16.775308641975307 0.9999997129603315 0.0843229057421363 19.41895808729367 KEGG_PATHWAY mmu04520:Adherens junction 4 4.938271604938271 0.016597677060940078 SMAD4, SMAD3, SMAD2, TCF7L1 42 76 5738 7.19047619047619 0.5811833383568494 0.049907007880935605 15.007777258980681 BIOCARTA m_ctcfPathway:CTCF: First Multivalent Nuclear Factor 4 4.938271604938271 0.02134003129232343 TRP53, SMAD5, SMAD4, SMAD1 39 19 1171 6.321187584345479 0.9005499075033139 0.5366934958279819 21.531376580375195 GOTERM_BP_FAT GO:0001756~somitogenesis 3 3.7037037037037033 0.024200972304546278 TRP53, SMAD3, FOXC1 81 41 13588 12.274616079494129 0.9999999999987268 0.1390072661577645 32.4682543866174 BIOCARTA m_nthiPathway:NFkB activation by Nontypeable Hemophilus influenzae 4 4.938271604938271 0.03566727325797425 RELA, SMAD4, SMAD3, NR3C1 39 23 1171 5.2218506131549605 0.9794752009049522 0.42601969879734625 33.51849025453786 KEGG_PATHWAY mmu04110:Cell cycle 4 4.938271604938271 0.06255906912849798 TRP53, SMAD4, SMAD3, SMAD2 42 128 5738 4.269345238095238 0.9652397077176059 0.15461571385525175 46.615285747215594 BIOCARTA m_g1Pathway:Cell Cycle: G1/S Check Point 3 3.7037037037037033 0.19320216111984342 TRP53, SMAD4, SMAD3 39 25 1171 3.603076923076923 0.9999999998943606 0.7620481385073399 91.04678344597087 GOTERM_BP_FAT GO:0007166~cell surface receptor linked signal transduction 16 19.753086419753085 0.5097217147988499 TRP53, SMAD7, SMAD6, SMAD5, SMAD4, SOX4, SMAD3, FOXO1, SMAD2, SMAD1, STAT1, STAT3, TCF7L1, HHEX, HEY1, FOXC1 81 2495 13588 1.0757712956777752 1.0 0.9527933243322934 99.99890460042164 Annotation Cluster 20 Enrichment Score: 4.971751438697619 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001501~skeletal system development 14 17.28395061728395 1.0386176395305703E-8 MEF2C, RARG, THRA, SMAD5, PRRX1, SMAD3, SMAD2, SMAD1, SOX6, MEF2D, HIF1A, SP1, PBX1, FOXC1 81 285 13588 8.240502490794889 1.1611677818490485E-5 1.9035646114939908E-7 1.6643078093458996E-5 GOTERM_BP_FAT GO:0060348~bone development 9 11.11111111111111 4.384043742599784E-7 MEF2C, MEF2D, THRA, RARG, SP1, SMAD5, SMAD3, FOXC1, SMAD1 81 118 13588 12.79472693032015 4.900161007238557E-4 7.001921169980108E-6 7.025082690015338E-4 GOTERM_BP_FAT GO:0001503~ossification 8 9.876543209876543 2.865994619715948E-6 MEF2C, MEF2D, THRA, SP1, SMAD5, SMAD3, FOXC1, SMAD1 81 106 13588 12.66061029583042 0.0031990586490596717 4.27215750936627E-5 0.004592445516371502 GOTERM_BP_FAT GO:0051216~cartilage development 7 8.641975308641975 6.3128080715795765E-6 MEF2C, MEF2D, THRA, RARG, HIF1A, PRRX1, SOX6 81 78 13588 15.054764165875275 0.007032894332018369 8.712881765882141E-5 0.010115328295934312 GOTERM_BP_FAT GO:0048705~skeletal system morphogenesis 7 8.641975308641975 1.1500752555650612E-4 MEF2C, MEF2D, THRA, RARG, PRRX1, SMAD3, SMAD2 81 130 13588 9.032858499525165 0.12066189495903523 0.001212338182835504 0.18413192006611068 GOTERM_BP_FAT GO:0001649~osteoblast differentiation 5 6.172839506172839 1.6392186270301697E-4 MEF2C, MEF2D, SMAD5, SMAD3, SMAD1 81 47 13588 17.846073023377986 0.1674647075430057 0.001664791464617843 0.26234945229027806 GOTERM_BP_FAT GO:0060349~bone morphogenesis 3 3.7037037037037033 0.010151921706608861 MEF2C, MEF2D, RARG 81 26 13588 19.356125356125354 0.9999888920863079 0.06527423046529646 15.084064254483643 Annotation Cluster 21 Enrichment Score: 4.885375485094255 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051890~regulation of cardioblast differentiation 4 4.938271604938271 1.9486826705080153E-6 GATA6, TBX5, GATA4, NKX2-5 81 5 13588 134.20246913580246 0.002176257858009345 3.025828315916801E-5 0.003122574131975142 GOTERM_BP_FAT GO:0051891~positive regulation of cardioblast differentiation 4 4.938271604938271 1.9486826705080153E-6 GATA6, TBX5, GATA4, NKX2-5 81 5 13588 134.20246913580246 0.002176257858009345 3.025828315916801E-5 0.003122574131975142 GOTERM_BP_FAT GO:0032583~regulation of gene-specific transcription 7 8.641975308641975 2.582019408688445E-6 HHEX, TAL1, RARG, GATA6, GATA4, SMAD2, NKX2-5 81 67 13588 17.52644186475032 0.002882538909433019 3.9008717866106934E-5 0.004137414868388145 GOTERM_BP_FAT GO:0010551~regulation of specific transcription from RNA polymerase II promoter 6 7.4074074074074066 1.1845809301145751E-5 HHEX, TAL1, RARG, GATA6, GATA4, NKX2-5 81 51 13588 19.735657225853302 0.013156381403382822 1.5221477323568156E-4 0.018980344149410744 GOTERM_BP_FAT GO:0007492~endoderm development 5 6.172839506172839 2.3655044807267854E-5 HHEX, GATA6, SMAD3, SMAD2, NKX2-5 81 29 13588 28.922945934440186 0.02610000280402247 2.8742230470757413E-4 0.03789872458191956 GOTERM_BP_FAT GO:0043193~positive regulation of gene-specific transcription 5 6.172839506172839 6.346784616202293E-5 RARG, GATA6, GATA4, SMAD2, NKX2-5 81 37 13588 22.669336002669336 0.06850020018827974 7.238124503795573E-4 0.1016540537783217 GOTERM_BP_FAT GO:0010552~positive regulation of specific transcription from RNA polymerase II promoter 4 4.938271604938271 3.638208494328058E-4 RARG, GATA6, GATA4, NKX2-5 81 24 13588 27.958847736625515 0.3342397911151874 0.0034417391838992284 0.5814053388696783 Annotation Cluster 22 Enrichment Score: 4.8832402486956 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013088:Zinc finger, NHR/GATA-type 12 14.814814814814813 4.887174714929882E-16 NR1H2, GATA2, THRA, RARG, GATA6, RXRB, RXRA, GATA4, RARA, RORA, NR3C1, NR2F2 81 53 17763 49.65199161425576 5.1514348342607263E-14 5.1514348342607263E-14 5.10702591327572E-13 SP_PIR_KEYWORDS zinc-finger 25 30.864197530864196 1.9502460147721864E-10 EGR1, THRA, RARG, RXRB, RXRA, NR3C1, RORA, MECOM, FOXP4, FOXP1, ATF2, NR1H2, ATRX, GATA2, SP1, GATA6, GATA4, ZFPM2, RARA, BCL6, RARB, ZFPM1, KLF2, NR2F2, RERE 80 1204 17854 4.634032392026579 1.3846743085466073E-8 1.3846742641376864E-9 2.024193812566466E-7 SP_PIR_KEYWORDS zinc 26 32.098765432098766 2.8830462160599563E-7 EGR1, TRP53, THRA, RARG, RXRB, RXRA, NR3C1, RORA, MECOM, FOXP4, FOXP1, ATF2, NR1H2, ATRX, GATA2, SP1, GATA6, GATA4, ZFPM2, RARA, BCL6, RARB, ZFPM1, KLF2, NR2F2, RERE 80 1886 17854 3.076643690349947 2.0469421584290437E-5 1.4621154372784773E-6 2.9923598452441524E-4 SP_PIR_KEYWORDS metal-binding 26 32.098765432098766 1.492449721344184E-4 EGR1, TRP53, THRA, RARG, RXRB, RXRA, NR3C1, RORA, MECOM, FOXP4, FOXP1, ATF2, NR1H2, ATRX, GATA2, SP1, GATA6, GATA4, ZFPM2, RARA, BCL6, RARB, ZFPM1, KLF2, NR2F2, RERE 80 2682 17854 2.163516032811335 0.010541231496995707 5.575910056623279E-4 0.15479558477554667 GOTERM_MF_FAT GO:0008270~zinc ion binding 27 33.33333333333333 1.6293530859308103E-4 THRA, NR3C1, RORA, ATF2, NR1H2, GATA2, GATA6, GATA4, BCL6, RARA, RARB, VEZF1, NR2F2, EGR1, TRP53, RARG, RXRB, RXRA, MECOM, FOXP4, FOXP1, ATRX, SP1, ZFPM2, ZFPM1, KLF2, RERE 81 2105 13288 2.104196357878068 0.011663743003380245 7.329998522250802E-4 0.16946561337731758 GOTERM_MF_FAT GO:0046914~transition metal ion binding 27 33.33333333333333 0.004353925863834386 THRA, NR3C1, RORA, ATF2, NR1H2, GATA2, GATA6, GATA4, BCL6, RARA, RARB, VEZF1, NR2F2, EGR1, TRP53, RARG, RXRB, RXRA, MECOM, FOXP4, FOXP1, ATRX, SP1, ZFPM2, ZFPM1, KLF2, RERE 81 2608 13288 1.698364008179959 0.26960302383777157 0.015585621767312818 4.4401985001362725 GOTERM_MF_FAT GO:0046872~metal ion binding 29 35.80246913580247 0.14309540600142046 THRA, NR3C1, RORA, ATF2, NR1H2, GATA2, GATA6, GATA4, BCL6, RARA, RARB, VEZF1, NR2F2, EGR1, TRP53, RARG, RXRB, RXRA, MECOM, STAT1, FOXP4, FOXP1, STAT3, ATRX, SP1, ZFPM2, ZFPM1, KLF2, RERE 81 3850 13288 1.2356966490299823 0.9999851701102174 0.32773478504724995 79.95944322118665 GOTERM_MF_FAT GO:0043169~cation binding 29 35.80246913580247 0.15542274761819633 THRA, NR3C1, RORA, ATF2, NR1H2, GATA2, GATA6, GATA4, BCL6, RARA, RARB, VEZF1, NR2F2, EGR1, TRP53, RARG, RXRB, RXRA, MECOM, STAT1, FOXP4, FOXP1, STAT3, ATRX, SP1, ZFPM2, ZFPM1, KLF2, RERE 81 3885 13288 1.2245642467864688 0.999994775612696 0.3425491541414647 82.76519117431123 GOTERM_MF_FAT GO:0043167~ion binding 29 35.80246913580247 0.1737411424951131 THRA, NR3C1, RORA, ATF2, NR1H2, GATA2, GATA6, GATA4, BCL6, RARA, RARB, VEZF1, NR2F2, EGR1, TRP53, RARG, RXRB, RXRA, MECOM, STAT1, FOXP4, FOXP1, STAT3, ATRX, SP1, ZFPM2, ZFPM1, KLF2, RERE 81 3934 13288 1.2093116672001607 0.9999989226390562 0.367473525659888 86.28230415394061 Annotation Cluster 23 Enrichment Score: 4.544473896983941 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000679:Zinc finger, GATA-type 5 6.172839506172839 6.661804070768409E-7 ATRX, GATA2, GATA6, GATA4, RERE 81 16 17763 68.53009259259258 7.727396717238655E-5 7.727665437329279E-6 7.600311605404642E-4 SMART SM00401:ZnF_GATA 5 6.172839506172839 8.29591608956208E-6 ATRX, GATA2, GATA6, GATA4, RERE 79 16 9131 36.11946202531646 2.737288959351325E-4 3.910871616674694E-5 0.007240870407887456 UP_SEQ_FEATURE zinc finger region:GATA-type 2 3 3.7037037037037033 3.465964442189338E-4 GATA2, GATA6, GATA4 79 6 16021 101.39873417721519 0.08523742323346017 0.0042334292066914525 0.45127476314649195 UP_SEQ_FEATURE zinc finger region:GATA-type 1 3 3.7037037037037033 3.465964442189338E-4 GATA2, GATA6, GATA4 79 6 16021 101.39873417721519 0.08523742323346017 0.0042334292066914525 0.45127476314649195 Annotation Cluster 24 Enrichment Score: 4.220216183442303 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RHD 5 6.172839506172839 6.429774941521198E-8 RELA, NFAT5, NFATC4, NFATC3, NFATC1 79 9 16021 112.66526019690576 1.65243856128372E-5 1.5022281573129348E-6 8.389171114453475E-5 INTERPRO IPR000451:NF-kappa-B/Rel/dorsal 5 6.172839506172839 7.846371199306305E-8 RELA, NFAT5, NFATC4, NFATC3, NFATC1 81 10 17763 109.64814814814814 9.101749524731417E-6 1.0113095937347438E-6 8.951786609756596E-5 INTERPRO IPR011539:Rel homology 5 6.172839506172839 7.846371199306305E-8 RELA, NFAT5, NFATC4, NFATC3, NFATC1 81 10 17763 109.64814814814814 9.101749524731417E-6 1.0113095937347438E-6 8.951786609756596E-5 KEGG_PATHWAY mmu04310:Wnt signaling pathway 10 12.345679012345679 7.267481782390653E-7 TRP53, JUN, SMAD4, NFAT5, SMAD3, NFATC4, SMAD2, NFATC3, TCF7L1, NFATC1 42 149 5738 9.1690635985938 3.7790204930443494E-5 1.88952809810905E-5 7.060807159509075E-4 INTERPRO IPR018286:Nuclear factor of activated T cells (NFAT), subgroup 4 4.938271604938271 8.739917763533012E-7 NFAT5, NFATC4, NFATC3, NFATC1 81 5 17763 175.43703703703702 1.0137795127407312E-4 9.216602105621696E-6 9.971176856304886E-4 INTERPRO IPR008366:Nuclear factor of activated T cells (NFAT) 4 4.938271604938271 8.739917763533012E-7 NFAT5, NFATC4, NFATC3, NFATC1 81 5 17763 175.43703703703702 1.0137795127407312E-4 9.216602105621696E-6 9.971176856304886E-4 INTERPRO IPR002909:Cell surface receptor IPT/TIG 5 6.172839506172839 1.2461061439443454E-5 RELA, NFAT5, NFATC4, NFATC3, NFATC1 81 32 17763 34.26504629629629 0.0014444479126265453 9.033917749456943E-5 0.014215689233754158 UP_SEQ_FEATURE short sequence motif:Nuclear localization signal 9 11.11111111111111 7.992886302697523E-5 HIF1A, JARID2, RELA, NFATC4, ZFPM2, MECOM, NFATC3, TCF7L1, NFATC1 79 289 16021 6.315492094082607 0.020332978251545786 0.001140601173858835 0.10423606236238392 UP_SEQ_FEATURE region of interest:Calcineurin-binding 3 3.7037037037037033 1.395189840039562E-4 NFATC4, NFATC3, NFATC1 79 4 16021 152.09810126582278 0.035223567301698955 0.0018855296483936135 0.18188287006012382 SMART SM00429:IPT 5 6.172839506172839 1.4776073478349645E-4 RELA, NFAT5, NFATC4, NFATC3, NFATC1 79 32 9131 18.05973101265823 0.004864593881994894 5.416826293761501E-4 0.1288995568281881 KEGG_PATHWAY mmu04662:B cell receptor signaling pathway 6 7.4074074074074066 2.349268934889338E-4 RELA, JUN, NFAT5, NFATC4, NFATC3, NFATC1 42 80 5738 10.24642857142857 0.012143301386450034 0.002440543747318946 0.22801317048898317 KEGG_PATHWAY mmu04660:T cell receptor signaling pathway 6 7.4074074074074066 0.0014010709768574796 RELA, JUN, NFAT5, NFATC4, NFATC3, NFATC1 42 118 5738 6.946731234866828 0.0703125053061846 0.00806803026609304 1.3529499668748945 KEGG_PATHWAY mmu04370:VEGF signaling pathway 4 4.938271604938271 0.016597677060940078 NFAT5, NFATC4, NFATC3, NFATC1 42 76 5738 7.19047619047619 0.5811833383568494 0.049907007880935605 15.007777258980681 KEGG_PATHWAY mmu04650:Natural killer cell mediated cytotoxicity 4 4.938271604938271 0.055699641888021005 NFAT5, NFATC4, NFATC3, NFATC1 42 122 5738 4.479313036690086 0.9492158686829294 0.14516868646663128 42.696780884622285 KEGG_PATHWAY mmu04360:Axon guidance 4 4.938271604938271 0.06613148060882575 NFAT5, NFATC4, NFATC3, NFATC1 42 131 5738 4.17157397310069 0.9714991211118145 0.14931987892512122 48.55932422737405 INTERPRO IPR013783:Immunoglobulin-like fold 5 6.172839506172839 0.32995681054246695 RELA, NFAT5, NFATC4, NFATC3, NFATC1 81 644 17763 1.702610996089257 1.0 0.7764946689261705 98.96238401861424 Annotation Cluster 25 Enrichment Score: 3.9704150913647362 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048844~artery morphogenesis 4 4.938271604938271 6.826751313591716E-5 SMAD7, PRRX1, FOXC1, PROX1 81 14 13588 47.929453262786595 0.07348559442627411 7.706693968082545E-4 0.10933755738153916 GOTERM_BP_FAT GO:0055010~ventricular cardiac muscle morphogenesis 4 4.938271604938271 8.497254182342117E-5 SMAD7, RXRA, FOXC1, PROX1 81 15 13588 44.73415637860082 0.09063010115293402 9.043844943048551E-4 0.13607533197083077 GOTERM_BP_FAT GO:0055008~cardiac muscle tissue morphogenesis 4 4.938271604938271 1.504608362055548E-4 SMAD7, RXRA, FOXC1, PROX1 81 18 13588 37.27846364883402 0.15483877503385424 0.0015564529414607842 0.24083003906836264 GOTERM_BP_FAT GO:0060415~muscle tissue morphogenesis 4 4.938271604938271 1.504608362055548E-4 SMAD7, RXRA, FOXC1, PROX1 81 18 13588 37.27846364883402 0.15483877503385424 0.0015564529414607842 0.24083003906836264 Annotation Cluster 26 Enrichment Score: 3.9537675772342444 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007369~gastrulation 7 8.641975308641975 4.638856970562149E-6 TRP53, GATA4, SMAD4, SMAD3, FOXC1, SMAD2, SMAD1 81 74 13588 15.868535201868534 0.005172828725521272 6.482607522706463E-5 0.007433166144343861 GOTERM_BP_FAT GO:0048617~embryonic foregut morphogenesis 4 4.938271604938271 1.0774138281488084E-5 GATA4, SMAD3, SMAD2, FOXP4 81 8 13588 83.87654320987653 0.011973294250728461 1.4005474361600267E-4 0.01726336239062931 GOTERM_BP_FAT GO:0007440~foregut morphogenesis 4 4.938271604938271 1.6092583735814515E-5 GATA4, SMAD3, SMAD2, FOXP4 81 9 13588 74.55692729766804 0.017830769885628706 2.0213297717541767E-4 0.025784057962252582 GOTERM_BP_FAT GO:0048567~ectodermal gut morphogenesis 4 4.938271604938271 6.826751313591716E-5 GATA4, SMAD3, SMAD2, FOXP4 81 14 13588 47.929453262786595 0.07348559442627411 7.706693968082545E-4 0.10933755738153916 GOTERM_BP_FAT GO:0007439~ectodermal gut development 4 4.938271604938271 6.826751313591716E-5 GATA4, SMAD3, SMAD2, FOXP4 81 14 13588 47.929453262786595 0.07348559442627411 7.706693968082545E-4 0.10933755738153916 GOTERM_BP_FAT GO:0048547~gut morphogenesis 4 4.938271604938271 4.63413259908972E-4 GATA4, SMAD3, SMAD2, FOXP4 81 26 13588 25.808167141500473 0.40441794503259865 0.00417044161522373 0.7400059599058206 GOTERM_BP_FAT GO:0048546~digestive tract morphogenesis 4 4.938271604938271 9.440527333530815E-4 GATA4, SMAD3, SMAD2, FOXP4 81 33 13588 20.333707444818558 0.6521380141800395 0.007849252391927686 1.50209351194317 GOTERM_BP_FAT GO:0055123~digestive system development 4 4.938271604938271 0.0010310416054567723 GATA4, SMAD3, SMAD2, FOXP4 81 34 13588 19.735657225853306 0.684406146825411 0.00844428596079927 1.6394328145543535 GOTERM_BP_FAT GO:0048565~gut development 4 4.938271604938271 0.0015417126424706119 GATA4, SMAD3, SMAD2, FOXP4 81 39 13588 17.205444761000315 0.8218206721875938 0.012074154555461347 2.442073670322198 Annotation Cluster 27 Enrichment Score: 3.812538397010771 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018122:Transcription factor, fork head, conserved site 5 6.172839506172839 3.7483099275003054E-5 FOXO1, FOXC1, FOXO3, FOXP4, FOXP1 81 42 17763 26.106701940035272 0.0043386816149492136 2.55739117112852E-4 0.042755483519474335 INTERPRO IPR001766:Transcription factor, fork head 5 6.172839506172839 3.7483099275003054E-5 FOXO1, FOXC1, FOXO3, FOXP4, FOXP1 81 42 17763 26.106701940035272 0.0043386816149492136 2.55739117112852E-4 0.042755483519474335 INTERPRO IPR011991:Winged helix repressor DNA-binding 7 8.641975308641975 1.3795056133369133E-4 ETS1, ETS2, FOXO1, FOXC1, FOXO3, FOXP4, FOXP1 81 175 17763 8.771851851851851 0.015875995441393842 7.617748914491296E-4 0.1572724820872451 SMART SM00339:FH 5 6.172839506172839 4.311204482742479E-4 FOXO1, FOXC1, FOXO3, FOXP4, FOXP1 79 42 9131 13.759795057263414 0.01412927393696739 0.0014219922540033014 0.37567781414544754 UP_SEQ_FEATURE DNA-binding region:Fork-head 4 4.938271604938271 0.0010358930860968612 FOXO1, FOXC1, FOXP4, FOXP1 79 41 16021 19.785118863846865 0.23383866284264798 0.010597942195670784 1.3431679299820032 Annotation Cluster 28 Enrichment Score: 3.7401347305293378 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035239~tube morphogenesis 12 14.814814814814813 4.49041400787467E-9 HHEX, TCF21, HIF1A, HAND2, GATA4, TBX20, SMAD4, SMAD3, PBX1, NR3C1, NKX2-5, SRF 81 171 13588 11.772146415421268 5.020270307021235E-6 8.508953719399415E-8 7.195556117611801E-6 GOTERM_BP_FAT GO:0001657~ureteric bud development 6 7.4074074074074066 4.470990463350371E-6 TCF21, SMAD4, FOXC1, PBX1, RARA, RARB 81 42 13588 23.964726631393297 0.004986106408289448 6.408228654353199E-5 0.007164190890751598 GOTERM_BP_FAT GO:0001656~metanephros development 6 7.4074074074074066 2.2375165500540947E-5 TCF21, SMAD4, FOXC1, PBX1, RARA, RARB 81 58 13588 17.35376756066411 0.02470541474507959 2.779137625472661E-4 0.03584852172068276 GOTERM_BP_FAT GO:0001655~urogenital system development 8 9.876543209876543 2.362039991356164E-5 TCF21, RARG, RXRA, SMAD4, FOXC1, PBX1, RARA, RARB 81 146 13588 9.191949940808387 0.02606227912173642 2.901548088981576E-4 0.03784322841486887 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 8 9.876543209876543 6.982618668428036E-5 HHEX, TCF21, RARG, TBX5, SMAD4, PBX1, NR3C1, PROX1 81 173 13588 7.757368158138871 0.07509884103689823 7.726558263940753E-4 0.11183262669148819 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 6 7.4074074074074066 2.1613643609895504E-4 HHEX, TCF21, TBX20, SMAD4, PBX1, SRF 81 93 13588 10.822779769016329 0.21468208269139855 0.0021554117299338316 0.34578088229538784 GOTERM_BP_FAT GO:0001822~kidney development 6 7.4074074074074066 4.146628909452946E-4 TCF21, SMAD4, FOXC1, PBX1, RARA, RARB 81 107 13588 9.406715126341295 0.37104103072460104 0.003824809324173284 0.662400803928842 GOTERM_BP_FAT GO:0001763~morphogenesis of a branching structure 6 7.4074074074074066 8.425316222576386E-4 HHEX, TCF21, TBX20, SMAD4, PBX1, SRF 81 125 13588 8.052148148148147 0.6102880444252198 0.007167680280862343 1.34158314078634 GOTERM_BP_FAT GO:0060562~epithelial tube morphogenesis 5 6.172839506172839 0.004142445701046802 HHEX, TCF21, SMAD4, PBX1, NR3C1 81 111 13588 7.5564453342231115 0.9903507320500589 0.028945432798977655 6.435345456710085 GOTERM_BP_FAT GO:0001658~branching involved in ureteric bud morphogenesis 3 3.7037037037037033 0.011718203919126827 TCF21, SMAD4, PBX1 81 28 13588 17.973544973544975 0.999998108833594 0.07459103090689256 17.211781015598902 GOTERM_BP_FAT GO:0060675~ureteric bud morphogenesis 3 3.7037037037037033 0.011718203919126827 TCF21, SMAD4, PBX1 81 28 13588 17.973544973544975 0.999998108833594 0.07459103090689256 17.211781015598902 GOTERM_BP_FAT GO:0007548~sex differentiation 4 4.938271604938271 0.0412698589055023 TCF21, FOXC1, PBX1, FOXO3 81 130 13588 5.161633428300095 1.0 0.21465722604137738 49.10231297304097 Annotation Cluster 29 Enrichment Score: 3.716772699233283 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045648~positive regulation of erythrocyte differentiation 4 4.938271604938271 1.0774138281488084E-5 TAL1, HIF1A, ETS1, FOXO3 81 8 13588 83.87654320987653 0.011973294250728461 1.4005474361600267E-4 0.01726336239062931 GOTERM_BP_FAT GO:0045646~regulation of erythrocyte differentiation 4 4.938271604938271 4.161286581842996E-5 TAL1, HIF1A, ETS1, FOXO3 81 12 13588 55.91769547325103 0.045458493788510745 4.948153256607579E-4 0.06666069884727621 GOTERM_BP_FAT GO:0045639~positive regulation of myeloid cell differentiation 4 4.938271604938271 4.116837376149404E-4 TAL1, HIF1A, ETS1, FOXO3 81 25 13588 26.840493827160493 0.3689417998701664 0.003828960647062063 0.6576564797746598 GOTERM_BP_FAT GO:0032844~regulation of homeostatic process 5 6.172839506172839 4.2292107456167084E-4 TAL1, HIF1A, ETS1, SMAD7, FOXO3 81 60 13588 13.979423868312756 0.3768236743717903 0.0038689370692938096 0.6755509130539683 GOTERM_BP_FAT GO:0045637~regulation of myeloid cell differentiation 4 4.938271604938271 0.0033396679884094525 TAL1, HIF1A, ETS1, FOXO3 81 51 13588 13.157104817235535 0.9762458367209473 0.02384023851819106 5.219384084313017 Annotation Cluster 30 Enrichment Score: 3.711730102347313 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046982~protein heterodimerization activity 11 13.580246913580247 2.590767952889043E-9 THRA, HIF1A, EPAS1, HAND2, PBX1, SOX6, NKX2-5, FOXP4, MEIS1, FOXP1, ARNT 81 121 13288 14.91358024691358 1.8653527400491754E-7 1.8653528943701758E-8 2.6966696986541194E-6 GOTERM_MF_FAT GO:0042803~protein homodimerization activity 5 6.172839506172839 0.02901897784073518 THRA, HAND2, NKX2-5, FOXP4, FOXP1 81 193 13288 4.249984008187807 0.8800021673030003 0.08455506720987505 26.399696964156448 GOTERM_MF_FAT GO:0042802~identical protein binding 5 6.172839506172839 0.09743142754526983 THRA, HAND2, NKX2-5, FOXP4, FOXP1 81 290 13288 2.828437633035334 0.9993768753627282 0.2391823962955979 65.59639972358421 Annotation Cluster 31 Enrichment Score: 3.6361231873094324 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007423~sensory organ development 11 13.580246913580247 2.530824170978834E-6 RARG, SP1, MAFB, PRRX1, SMAD3, FOXC1, RARB, NKX2-5, PROX1, MEIS1, STAT3 81 257 13588 7.180093193063361 0.002825465840246455 3.875904341910097E-5 0.004055381437495509 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 9 11.11111111111111 4.589333947263129E-6 RARG, SP1, MAFB, GATA4, PRRX1, SMAD3, SMAD2, RARB, PROX1 81 161 13588 9.37750172532781 0.005117746609205831 6.494582924199133E-5 0.007353814663746405 GOTERM_BP_FAT GO:0001654~eye development 8 9.876543209876543 3.768339273177207E-5 RARG, SP1, SMAD3, FOXC1, RARB, PROX1, MEIS1, STAT3 81 157 13588 8.547927970433278 0.04125565717849489 4.5291704613104056E-4 0.06036775866723465 GOTERM_BP_FAT GO:0048048~embryonic eye morphogenesis 4 4.938271604938271 6.826751313591716E-5 RARG, SP1, RARB, PROX1 81 14 13588 47.929453262786595 0.07348559442627411 7.706693968082545E-4 0.10933755738153916 GOTERM_BP_FAT GO:0048592~eye morphogenesis 6 7.4074074074074066 6.846504454309879E-5 RARG, SP1, RARB, PROX1, MEIS1, STAT3 81 73 13588 13.787924911212581 0.07369019736728744 7.651725081990746E-4 0.10965376188248888 GOTERM_BP_FAT GO:0043010~camera-type eye development 5 6.172839506172839 0.007224765481721743 SP1, SMAD3, FOXC1, PROX1, MEIS1 81 130 13588 6.452041785375118 0.9996984598451082 0.04851731265268455 10.969551724071936 GOTERM_BP_FAT GO:0002088~lens development in camera-type eye 3 3.7037037037037033 0.0170005396044949 SMAD3, PROX1, MEIS1 81 34 13588 14.801742919389978 0.9999999952732089 0.10264631207588104 24.024807181097753 GOTERM_BP_FAT GO:0048593~camera-type eye morphogenesis 3 3.7037037037037033 0.03242525741409112 SP1, PROX1, MEIS1 81 48 13588 10.484567901234568 0.9999999999999999 0.17547136570289856 41.033537964740965 Annotation Cluster 32 Enrichment Score: 3.393671521207976 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000910:High mobility group, HMG1/HMG2 5 6.172839506172839 8.115334709806791E-5 TFAM, SOX4, PBRM1, SOX6, TCF7L1 81 51 17763 21.499636891793756 0.00936999569435859 4.953599142321075E-4 0.09254736675701203 UP_SEQ_FEATURE DNA-binding region:HMG box 4 4.938271604938271 8.943156484948479E-4 SOX4, PBRM1, SOX6, TCF7L1 79 39 16021 20.799740344044142 0.2054202793153307 0.009535164152040476 1.1605827296572002 SMART SM00398:HMG 5 6.172839506172839 9.082139530649097E-4 TFAM, SOX4, PBRM1, SOX6, TCF7L1 79 51 9131 11.331595929511046 0.029539597913490923 0.002722168050583895 0.7899593778624259 Annotation Cluster 33 Enrichment Score: 3.23075507982061 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048736~appendage development 7 8.641975308641975 7.044181110545935E-5 RARG, TBX5, PRRX1, PBX1, RARB, NR2F2, MECOM 81 119 13588 9.867828612926651 0.07573524660268549 7.718266818802499E-4 0.11281808032356233 GOTERM_BP_FAT GO:0060173~limb development 7 8.641975308641975 7.044181110545935E-5 RARG, TBX5, PRRX1, PBX1, RARB, NR2F2, MECOM 81 119 13588 9.867828612926651 0.07573524660268549 7.718266818802499E-4 0.11281808032356233 GOTERM_BP_FAT GO:0035113~embryonic appendage morphogenesis 6 7.4074074074074066 2.631501820528254E-4 RARG, TBX5, PRRX1, PBX1, RARB, MECOM 81 97 13588 10.37647957235586 0.2549028153901458 0.002577730003455181 0.42084614484472205 GOTERM_BP_FAT GO:0030326~embryonic limb morphogenesis 6 7.4074074074074066 2.631501820528254E-4 RARG, TBX5, PRRX1, PBX1, RARB, MECOM 81 97 13588 10.37647957235586 0.2549028153901458 0.002577730003455181 0.42084614484472205 GOTERM_BP_FAT GO:0035108~limb morphogenesis 6 7.4074074074074066 5.771327080472372E-4 RARG, TBX5, PRRX1, PBX1, RARB, MECOM 81 115 13588 8.75233494363929 0.4755581014422481 0.005109288923045852 0.9208137526879767 GOTERM_BP_FAT GO:0035107~appendage morphogenesis 6 7.4074074074074066 5.771327080472372E-4 RARG, TBX5, PRRX1, PBX1, RARB, MECOM 81 115 13588 8.75233494363929 0.4755581014422481 0.005109288923045852 0.9208137526879767 GOTERM_BP_FAT GO:0035116~embryonic hindlimb morphogenesis 3 3.7037037037037033 0.007326168494704575 RARG, RARB, MECOM 81 22 13588 22.875420875420875 0.9997310020474388 0.04889125095733293 11.115159066541302 GOTERM_BP_FAT GO:0035137~hindlimb morphogenesis 3 3.7037037037037033 0.0170005396044949 RARG, RARB, MECOM 81 34 13588 14.801742919389978 0.9999999952732089 0.10264631207588104 24.024807181097753 Annotation Cluster 34 Enrichment Score: 3.114888937737274 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0040008~regulation of growth 9 11.11111111111111 1.279063357029277E-4 TRP53, HIF1A, CREB1, TBX5, GATA4, HOPX, FOXC1, PROX1, STAT3 81 256 13588 5.897569444444444 0.13325323724967086 0.0013356346221901072 0.20476362387269464 GOTERM_BP_FAT GO:0046620~regulation of organ growth 4 4.938271604938271 9.440527333530815E-4 TBX5, GATA4, FOXC1, PROX1 81 33 13588 20.333707444818558 0.6521380141800395 0.007849252391927686 1.50209351194317 GOTERM_BP_FAT GO:0048638~regulation of developmental growth 4 4.938271604938271 0.0013218932827174213 TBX5, GATA4, HOPX, PROX1 81 37 13588 18.135468802135467 0.772101368911725 0.010582843393139862 2.09733105400296 GOTERM_BP_FAT GO:0060420~regulation of heart growth 3 3.7037037037037033 0.002174500651032281 TBX5, GATA4, PROX1 81 12 13588 41.93827160493827 0.9122917024464616 0.016309713421704952 3.428131595680317 Annotation Cluster 35 Enrichment Score: 3.0815310137761736 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu05223:Non-small cell lung cancer 5 6.172839506172839 5.482294696887789E-4 TRP53, RXRB, RXRA, FOXO3, RARB 42 54 5738 12.649911816578483 0.02811301292757251 0.004065392359361875 0.5313697257960048 GOTERM_BP_FAT GO:0040007~growth 7 8.641975308641975 9.54851939896638E-4 TRP53, RXRB, RXRA, SMAD3, FOXC1, SMAD2, FOXO3 81 193 13588 6.084308833877055 0.6563166217038328 0.007880153857570127 1.5191532266838115 KEGG_PATHWAY mmu05216:Thyroid cancer 4 4.938271604938271 0.00108769854326708 TRP53, RXRB, RXRA, TCF7L1 42 29 5738 18.844006568144497 0.05501961362690222 0.00704892730173623 1.0517745234916442 Annotation Cluster 36 Enrichment Score: 3.072518607029393 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035265~organ growth 4 4.938271604938271 2.79178191288139E-4 RXRB, RXRA, FOXC1, SMAD2 81 22 13588 30.500561167227833 0.26813908850141177 0.002710795615579853 0.44642540644360684 GOTERM_BP_FAT GO:0014855~striated muscle cell proliferation 3 3.7037037037037033 7.052403812545368E-4 RXRB, RXRA, FOXC1 81 7 13588 71.8941798941799 0.5455815927587834 0.006143060828691094 1.124128154880566 GOTERM_BP_FAT GO:0055017~cardiac muscle tissue growth 3 3.7037037037037033 7.052403812545368E-4 RXRB, RXRA, FOXC1 81 7 13588 71.8941798941799 0.5455815927587834 0.006143060828691094 1.124128154880566 GOTERM_BP_FAT GO:0060419~heart growth 3 3.7037037037037033 7.052403812545368E-4 RXRB, RXRA, FOXC1 81 7 13588 71.8941798941799 0.5455815927587834 0.006143060828691094 1.124128154880566 GOTERM_BP_FAT GO:0060038~cardiac muscle cell proliferation 3 3.7037037037037033 7.052403812545368E-4 RXRB, RXRA, FOXC1 81 7 13588 71.8941798941799 0.5455815927587834 0.006143060828691094 1.124128154880566 GOTERM_BP_FAT GO:0040007~growth 7 8.641975308641975 9.54851939896638E-4 TRP53, RXRB, RXRA, SMAD3, FOXC1, SMAD2, FOXO3 81 193 13588 6.084308833877055 0.6563166217038328 0.007880153857570127 1.5191532266838115 GOTERM_BP_FAT GO:0033002~muscle cell proliferation 3 3.7037037037037033 0.0011997681418093517 RXRB, RXRA, FOXC1 81 9 13588 55.91769547325103 0.7387156694901712 0.009748855472083595 1.9053090160397246 GOTERM_BP_FAT GO:0008283~cell proliferation 7 8.641975308641975 0.0033234382039912165 TRP53, HHEX, RXRB, RXRA, TBX20, FOXC1, NCOR2 81 247 13588 4.754136052381666 0.9758094185089867 0.02387778485700809 5.194648838879823 Annotation Cluster 37 Enrichment Score: 2.859680439945311 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Leucine-zipper 7 8.641975308641975 1.3402510953365457E-5 MAFB, CREB1, JUN, NFE2L2, FOXP4, FOXP1, ATF2 79 107 16021 13.267124097953388 0.0034385430212736656 2.1525610391304184E-4 0.01748535919964267 INTERPRO IPR004827:Basic-leucine zipper (bZIP) transcription factor 5 6.172839506172839 1.0165417784911868E-4 MAFB, CREB1, JUN, NFE2L2, ATF2 81 54 17763 20.305212620027433 0.011723225190493625 5.894504067246453E-4 0.11591416991925119 INTERPRO IPR011616:bZIP transcription factor, bZIP-1 4 4.938271604938271 3.271579369216166E-4 CREB1, JUN, NFE2L2, ATF2 81 30 17763 29.239506172839505 0.037245208982471634 0.0015802721326289015 0.3726140103098352 SMART SM00338:BRLZ 5 6.172839506172839 0.0011273379240560927 MAFB, CREB1, JUN, NFE2L2, ATF2 79 54 9131 10.702062822315987 0.03653887243030007 0.0030971220721121018 0.9797227662930674 BIOCARTA m_mapkPathway:MAPKinase Signaling Pathway 6 7.4074074074074066 0.11146593870420257 MEF2A, SP1, CREB1, JUN, STAT1, ATF2 39 80 1171 2.251923076923077 0.9999967779917542 0.6513867518806985 73.51099766070999 BIOCARTA m_arenrf2Pathway:Oxidative Stress Induced Gene Expression Via Nrf2 3 3.7037037037037033 0.1240658346418353 CREB1, JUN, NFE2L2 39 19 1171 4.7408906882591095 0.9999993010487706 0.6638787938460098 77.43972142841693 Annotation Cluster 38 Enrichment Score: 2.7756036645154043 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002100:Transcription factor, MADS-box 4 4.938271604938271 8.739917763533012E-7 MEF2C, MEF2D, MEF2A, SRF 81 5 17763 175.43703703703702 1.0137795127407312E-4 9.216602105621696E-6 9.971176856304886E-4 UP_SEQ_FEATURE domain:MADS-box 4 4.938271604938271 1.102442887645122E-6 MEF2C, MEF2D, MEF2A, SRF 79 5 16021 162.2379746835443 2.8328784472031465E-4 2.179422237180706E-5 0.001438390032493242 SMART SM00432:MADS 4 4.938271604938271 5.9240450749103234E-6 MEF2C, MEF2D, MEF2A, SRF 79 5 9131 92.46582278481013 1.9547495881133692E-4 3.258181362308932E-5 0.005170693070233323 UP_SEQ_FEATURE region of interest:Beta domain 3 3.7037037037037033 6.99807574468845E-5 MEF2C, MEF2D, MEF2A 79 3 16021 202.79746835443038 0.01782490692085592 0.0010574219465785406 0.09126810277764186 UP_SEQ_FEATURE DNA-binding region:Mef2-type 3 3.7037037037037033 1.395189840039562E-4 MEF2C, MEF2D, MEF2A 79 4 16021 152.09810126582278 0.035223567301698955 0.0018855296483936135 0.18188287006012382 UP_SEQ_FEATURE site:Cleavage 4 4.938271604938271 0.0015430448430808978 MEF2C, MEF2D, MEF2A, SP1 79 47 16021 17.259359008887692 0.32757775610546436 0.01407390898803218 1.9946628058470028 SP_PIR_KEYWORDS Apoptosis 5 6.172839506172839 0.06232712730661673 MEF2C, TRP53, MEF2D, MEF2A, MECOM 80 337 17854 3.3112017804154306 0.9896331698904418 0.16703675321540123 48.72376701852431 SP_PIR_KEYWORDS neurogenesis 3 3.7037037037037033 0.13350818451120444 MEF2C, MEF2D, MEF2A 80 144 17854 4.649479166666667 0.9999618691041655 0.3238405599575015 77.40322091786639 GOTERM_BP_FAT GO:0006915~apoptosis 6 7.4074074074074066 0.13880633955770788 MEF2C, TRP53, MEF2D, MEF2A, GATA6, HAND2 81 465 13588 2.1645559538032653 1.0 0.5194193040509603 90.87907865179822 GOTERM_BP_FAT GO:0012501~programmed cell death 6 7.4074074074074066 0.14602189132703633 MEF2C, TRP53, MEF2D, MEF2A, GATA6, HAND2 81 473 13588 2.127946127946128 1.0 0.5357290238446781 92.02951624297752 GOTERM_BP_FAT GO:0008219~cell death 6 7.4074074074074066 0.1784198670135318 MEF2C, TRP53, MEF2D, MEF2A, GATA6, HAND2 81 507 13588 1.985243626269267 1.0 0.6073988419076062 95.71127460094858 GOTERM_BP_FAT GO:0016265~death 6 7.4074074074074066 0.19047073206199278 MEF2C, TRP53, MEF2D, MEF2A, GATA6, HAND2 81 519 13588 1.9393420395347178 1.0 0.6309327827442889 96.6154995952918 Annotation Cluster 39 Enrichment Score: 2.675007810124799 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Homeobox 8 9.876543209876543 1.6317832324483692E-4 IRX4, HHEX, HOPX, PRRX1, PBX1, NKX2-5, PROX1, MEIS1 80 263 17854 6.788593155893537 0.01151974009464174 5.791625364736097E-4 0.16923607817168618 INTERPRO IPR012287:Homeodomain-related 8 9.876543209876543 1.6581050015020076E-4 IRX4, HHEX, HOPX, PRRX1, PBX1, NKX2-5, MEIS1, NCOR2 81 259 17763 6.7736307736307735 0.019051788936760405 8.739639070103333E-4 0.18900719549306277 INTERPRO IPR017970:Homeobox, conserved site 7 8.641975308641975 4.95509396241472E-4 IRX4, HHEX, HOPX, PRRX1, PBX1, NKX2-5, MEIS1 81 222 17763 6.914748081414748 0.055871817383329025 0.002297091054456857 0.5638625681986364 INTERPRO IPR001356:Homeobox 7 8.641975308641975 0.0010007965337322615 IRX4, HHEX, HOPX, PRRX1, PBX1, NKX2-5, MEIS1 81 254 17763 6.043598716827063 0.10965880908030068 0.0041396411488469065 1.1358631306644273 UP_SEQ_FEATURE DNA-binding region:Homeobox; TALE-type 3 3.7037037037037033 0.003035189156902249 IRX4, PBX1, MEIS1 79 17 16021 35.78778853313477 0.5421573917779559 0.024886067946160217 3.8885278026487335 SMART SM00389:HOX 7 8.641975308641975 0.02116639735044487 IRX4, HHEX, HOPX, PRRX1, PBX1, NKX2-5, MEIS1 79 254 9131 3.1853383833349946 0.5063800446728939 0.04917743657785867 17.03360210348951 UP_SEQ_FEATURE DNA-binding region:Homeobox 3 3.7037037037037033 0.2184944651515671 HHEX, PRRX1, NKX2-5 79 180 16021 3.379957805907173 1.0 0.7708698174418477 95.99093189490208 Annotation Cluster 40 Enrichment Score: 2.5263358535764664 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048705~skeletal system morphogenesis 7 8.641975308641975 1.1500752555650612E-4 MEF2C, MEF2D, THRA, RARG, PRRX1, SMAD3, SMAD2 81 130 13588 9.032858499525165 0.12066189495903523 0.001212338182835504 0.18413192006611068 GOTERM_BP_FAT GO:0048706~embryonic skeletal system development 5 6.172839506172839 0.0014388466425857601 SP1, PRRX1, SMAD3, PBX1, SMAD2 81 83 13588 10.105607615647775 0.8000701940014374 0.011432637445866645 2.280890896129195 GOTERM_BP_FAT GO:0048701~embryonic cranial skeleton morphogenesis 3 3.7037037037037033 0.00868705437906742 PRRX1, SMAD3, SMAD2 81 24 13588 20.969135802469136 0.9999419704151448 0.05740496407552931 13.047811884265991 GOTERM_BP_FAT GO:0048704~embryonic skeletal system morphogenesis 3 3.7037037037037033 0.054581224970567985 PRRX1, SMAD3, SMAD2 81 64 13588 7.863425925925925 1.0 0.27045064435953103 59.318571130392314 Annotation Cluster 41 Enrichment Score: 2.445846128513742 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018186:Transcription factor, T-box, conserved site 3 3.7037037037037033 0.0026072989311545242 TBX2, TBX5, TBX20 81 17 17763 38.69934640522875 0.2612839350962488 0.010388478529859801 2.934586842476261 INTERPRO IPR001699:Transcription factor, T-box 3 3.7037037037037033 0.0026072989311545242 TBX2, TBX5, TBX20 81 17 17763 38.69934640522875 0.2612839350962488 0.010388478529859801 2.934586842476261 UP_SEQ_FEATURE DNA-binding region:T-box 3 3.7037037037037033 0.0026865635601530822 TBX2, TBX5, TBX20 79 16 16021 38.024525316455694 0.4991136070026251 0.02278233780182204 3.4490943301670685 SMART SM00425:TBOX 3 3.7037037037037033 0.009016473548333194 TBX2, TBX5, TBX20 79 17 9131 20.39687267311988 0.25836134496326824 0.022729483265455208 7.601308534658068 Annotation Cluster 42 Enrichment Score: 2.4443292894271718 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 6 7.4074074074074066 7.5494021375412E-4 TRP53, TFAM, GATA4, NFAT5, SMAD3, STAT3 81 122 13588 8.250151791135398 0.570159862607823 0.006523912419153732 1.2028993403763066 GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 6 7.4074074074074066 8.733481949934E-4 TRP53, TFAM, GATA4, NFAT5, SMAD3, STAT3 81 126 13588 7.988242210464432 0.6234972397522108 0.007317680158223094 1.3903317143278415 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 3 3.7037037037037033 0.07045505284191989 GATA4, SMAD3, STAT3 81 74 13588 6.8008008008008005 1.0 0.3286367479164958 68.98608869911406 Annotation Cluster 43 Enrichment Score: 2.4160920153473646 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0033500~carbohydrate homeostasis 4 4.938271604938271 0.0016596902869470513 HIF1A, FOXO3, NCOR2, STAT3 81 40 13588 16.775308641975307 0.84387139999561 0.01281355424975017 2.6266282793299123 GOTERM_BP_FAT GO:0042593~glucose homeostasis 4 4.938271604938271 0.0016596902869470513 HIF1A, FOXO3, NCOR2, STAT3 81 40 13588 16.775308641975307 0.84387139999561 0.01281355424975017 2.6266282793299123 GOTERM_BP_FAT GO:0048878~chemical homeostasis 7 8.641975308641975 0.020496034773616473 TRP53, HIF1A, EPAS1, SMAD7, FOXO3, NCOR2, STAT3 81 365 13588 3.2171824792829358 0.9999999999119094 0.11945336477934676 28.240239189129433 Annotation Cluster 44 Enrichment Score: 2.238544625534153 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014031~mesenchymal cell development 4 4.938271604938271 0.002644581349881467 HIF1A, HAND2, FOXC1, NFATC1 81 47 13588 14.276858418702389 0.9482100102094184 0.019543555416820402 4.154588981852547 GOTERM_BP_FAT GO:0048762~mesenchymal cell differentiation 4 4.938271604938271 0.0029796287777955274 HIF1A, HAND2, FOXC1, NFATC1 81 49 13588 13.694129503653313 0.9644280460132741 0.02170955008014186 4.669236649025466 GOTERM_BP_FAT GO:0060485~mesenchyme development 4 4.938271604938271 0.003156487737841491 HIF1A, HAND2, FOXC1, NFATC1 81 50 13588 13.420246913580247 0.9708276690096842 0.02283673582893031 4.939853894658297 GOTERM_BP_FAT GO:0014033~neural crest cell differentiation 3 3.7037037037037033 0.016061157369392523 HIF1A, HAND2, FOXC1 81 33 13588 15.250280583613918 0.9999999862487604 0.09827058031595015 22.852991471383945 GOTERM_BP_FAT GO:0014032~neural crest cell development 3 3.7037037037037033 0.016061157369392523 HIF1A, HAND2, FOXC1 81 33 13588 15.250280583613918 0.9999999862487604 0.09827058031595015 22.852991471383945 Annotation Cluster 45 Enrichment Score: 2.234944375902426 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015880:Zinc finger, C2H2-like 11 13.580246913580247 8.880326872138599E-4 EGR1, SP1, BCL6, ZFPM2, ZFPM1, MECOM, VEZF1, KLF2, FOXP4, FOXP1, ATF2 81 676 17763 3.5684308568923955 0.09792494940711305 0.003955906923671204 1.00847184740811 INTERPRO IPR007087:Zinc finger, C2H2-type 11 13.580246913580247 9.392400910262923E-4 EGR1, SP1, BCL6, ZFPM2, ZFPM1, MECOM, VEZF1, KLF2, FOXP4, FOXP1, ATF2 81 681 17763 3.542230924022407 0.10327231626344169 0.004029011613604028 1.0663402951238243 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 7 8.641975308641975 0.0014238543883172028 EGR1, SP1, BCL6, ZFPM2, ZFPM1, MECOM, KLF2 79 252 16021 5.6332630098452885 0.3066298818114158 0.013985562860140632 1.841907036365742 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 7 8.641975308641975 0.001482338552349827 EGR1, SP1, BCL6, ZFPM2, ZFPM1, MECOM, KLF2 79 254 16021 5.588906608192963 0.31698854222352746 0.014020913409520386 1.9168884200476133 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 7 8.641975308641975 0.0016365826503147885 EGR1, SP1, BCL6, ZFPM2, ZFPM1, MECOM, KLF2 79 259 16021 5.481012658227848 0.3435746441540619 0.014410548989549077 2.1143881106612805 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 7 8.641975308641975 0.0283293334540384 EGR1, SP1, BCL6, ZFPM1, MECOM, VEZF1, KLF2 81 514 17763 2.986525435941778 0.96433726146519 0.1051700950697374 27.954399772690085 SMART SM00355:ZnF_C2H2 11 13.580246913580247 0.06093886483659398 EGR1, SP1, BCL6, ZFPM2, ZFPM1, MECOM, VEZF1, KLF2, FOXP4, FOXP1, ATF2 79 676 9131 1.8807767208448805 0.8744266140064307 0.12918378543870201 42.2358993988913 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 3 3.7037037037037033 0.26531254034363577 BCL6, ZFPM1, MECOM 79 206 16021 2.953361189627627 1.0 0.8348351540811906 98.20943727712725 Annotation Cluster 46 Enrichment Score: 1.9801072739524874 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001829~trophectodermal cell differentiation 3 3.7037037037037033 0.0038937488250393123 SP1, HOPX, SRF 81 16 13588 31.4537037037037 0.9872434243924519 0.027399223080877944 6.060218867792832 GOTERM_BP_FAT GO:0001825~blastocyst formation 3 3.7037037037037033 0.007326168494704575 SP1, HOPX, SRF 81 22 13588 22.875420875420875 0.9997310020474388 0.04889125095733293 11.115159066541302 GOTERM_BP_FAT GO:0001824~blastocyst development 3 3.7037037037037033 0.0402191920914924 SP1, HOPX, SRF 81 54 13588 9.319615912208505 1.0 0.21066817851206665 48.20110796378654 Annotation Cluster 47 Enrichment Score: 1.7919740120349494 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045596~negative regulation of cell differentiation 7 8.641975308641975 7.032718146440088E-4 TRP53, HOPX, SMAD3, BCL6, PBX1, MEIS1, NCOR2 81 182 13588 6.452041785375118 0.544579674871147 0.006174046758829488 1.1210068855166844 GOTERM_BP_FAT GO:0060284~regulation of cell development 6 7.4074074074074066 0.002444907701078844 TRP53, SMAD4, PBX1, SMAD2, PROX1, MEIS1 81 159 13588 6.330305147915211 0.9352196997202707 0.018199820663361344 3.8466438116939283 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 3 3.7037037037037033 0.1823799359335291 TRP53, PBX1, MEIS1 81 132 13588 3.8125701459034795 1.0 0.6147599331571166 96.03079877996188 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 3 3.7037037037037033 0.2166412796082642 TRP53, PBX1, MEIS1 81 148 13588 3.4004004004004003 1.0 0.6778314328600803 98.00106639848316 Annotation Cluster 48 Enrichment Score: 1.705851573909354 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042981~regulation of apoptosis 11 13.580246913580247 0.001458319318810587 TRP53, RARG, HIF1A, TBX5, FOXO1, FOXC1, BCL6, FOXO3, NR3C1, RARB, NKX2-5 81 553 13588 3.336860670194003 0.8043818977006947 0.011504874132469145 2.311422164548771 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 11 13.580246913580247 0.001601442312374535 TRP53, RARG, HIF1A, TBX5, FOXO1, FOXC1, BCL6, FOXO3, NR3C1, RARB, NKX2-5 81 560 13588 3.2951499118165786 0.8333480309507477 0.012452224583504146 2.535550846471546 GOTERM_BP_FAT GO:0010941~regulation of cell death 11 13.580246913580247 0.0016661886909827828 TRP53, RARG, HIF1A, TBX5, FOXO1, FOXC1, BCL6, FOXO3, NR3C1, RARB, NKX2-5 81 563 13588 3.2775913865315873 0.84500347315692 0.01277529806978539 2.636784334879516 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 6 7.4074074074074066 0.01542671545016574 TRP53, RARG, TBX5, FOXO3, NR3C1, RARB 81 248 13588 4.058542413381122 0.9999999717305714 0.09558866985664616 22.052003984868186 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 6 7.4074074074074066 0.01591984805303996 TRP53, RARG, TBX5, FOXO3, NR3C1, RARB 81 250 13588 4.0260740740740735 0.9999999838538751 0.09797456586699194 22.675258345992145 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 6 7.4074074074074066 0.01642343631390459 TRP53, RARG, TBX5, FOXO3, NR3C1, RARB 81 252 13588 3.994121105232216 0.9999999908896247 0.0998486296411093 23.30690304653047 GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 5 6.172839506172839 0.05239045547671205 TRP53, FOXO1, FOXC1, BCL6, NKX2-5 81 239 13588 3.509478795392324 1.0 0.2620297025292171 57.78139840903383 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 5 6.172839506172839 0.055726756341577297 TRP53, FOXO1, FOXC1, BCL6, NKX2-5 81 244 13588 3.4375632463064156 1.0 0.2742349451626529 60.101294554395544 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 5 6.172839506172839 0.056407591726106744 TRP53, FOXO1, FOXC1, BCL6, NKX2-5 81 245 13588 3.4235323759133283 1.0 0.2748287081436268 60.55978521749115 GOTERM_BP_FAT GO:0006917~induction of apoptosis 3 3.7037037037037033 0.25799264826371304 TRP53, TBX5, FOXO3 81 167 13588 3.0135284985584385 1.0 0.7409243318846896 99.16172330715834 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 3 3.7037037037037033 0.25799264826371304 TRP53, TBX5, FOXO3 81 167 13588 3.0135284985584385 1.0 0.7409243318846896 99.16172330715834 Annotation Cluster 49 Enrichment Score: 1.5865187608096152 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 5 6.172839506172839 0.004554685964269506 EGR1, TRP53, SOX4, BCL6, FOXP1 81 114 13588 7.357591509638293 0.9939261996833945 0.03158947675421897 7.054063797787213 GOTERM_BP_FAT GO:0046649~lymphocyte activation 6 7.4074074074074066 0.005344563328905556 EGR1, TRP53, SOX4, SMAD3, BCL6, FOXP1 81 191 13588 5.269730463447741 0.9974994545707346 0.03652882693600279 8.228863429669165 GOTERM_BP_FAT GO:0045321~leukocyte activation 6 7.4074074074074066 0.009392845057594915 EGR1, TRP53, SOX4, SMAD3, BCL6, FOXP1 81 219 13588 4.595974970404194 0.9999738282472211 0.06158145179970731 14.03455104550666 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 5 6.172839506172839 0.009794577574160416 EGR1, TRP53, SOX4, BCL6, FOXP1 81 142 13588 5.906798817596939 0.9999833702526235 0.06340272305246841 14.59149933613576 GOTERM_BP_FAT GO:0001775~cell activation 6 7.4074074074074066 0.014943948873611102 EGR1, TRP53, SOX4, SMAD3, BCL6, FOXP1 81 246 13588 4.091538693164709 0.9999999510971144 0.09323211412570687 21.437290830577215 GOTERM_BP_FAT GO:0030183~B cell differentiation 3 3.7037037037037033 0.02997649569957268 TRP53, BCL6, FOXP1 81 46 13588 10.940418679549113 0.9999999999999983 0.16555711258846129 38.59617076909901 GOTERM_BP_FAT GO:0042110~T cell activation 4 4.938271604938271 0.030980420912109414 EGR1, TRP53, SOX4, SMAD3 81 116 13588 5.784589186888037 0.9999999999999994 0.16904432327019814 39.606631096594825 GOTERM_BP_FAT GO:0030217~T cell differentiation 3 3.7037037037037033 0.07379187438294525 EGR1, TRP53, SOX4 81 76 13588 6.621832358674463 1.0 0.33769405450278867 70.72278736947423 GOTERM_BP_FAT GO:0042113~B cell activation 3 3.7037037037037033 0.07717883212171096 TRP53, BCL6, FOXP1 81 78 13588 6.452041785375118 1.0 0.34793262843105566 72.39202795984485 GOTERM_BP_FAT GO:0006955~immune response 3 3.7037037037037033 0.7705814743402758 TRP53, BCL6, FOXP1 81 471 13588 1.0684909963041596 1.0 0.9978972800055679 99.99999999431743 Annotation Cluster 50 Enrichment Score: 1.2073082794249708 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 7 8.641975308641975 0.03332043846557272 SP1, CREB1, SMAD5, FOXC1, BCL6, FOXO3, SMAD1 81 409 13588 2.8710797186754804 1.0 0.17907886669548634 41.90168564699548 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 7 8.641975308641975 0.03332043846557272 SP1, CREB1, SMAD5, FOXC1, BCL6, FOXO3, SMAD1 81 409 13588 2.8710797186754804 1.0 0.17907886669548634 41.90168564699548 GOTERM_BP_FAT GO:0019953~sexual reproduction 6 7.4074074074074066 0.07713182918962862 SMAD5, FOXC1, BCL6, FOXO3, SMAD1, STAT3 81 386 13588 2.607560928804452 1.0 0.3490880549496046 72.36948629025625 GOTERM_BP_FAT GO:0048610~reproductive cellular process 4 4.938271604938271 0.08201199504796582 RXRA, SMAD5, FOXC1, FOXO3 81 173 13588 3.8786840790694357 1.0 0.3645388964982178 74.62006435643713 GOTERM_BP_FAT GO:0007276~gamete generation 5 6.172839506172839 0.13089594109925395 SMAD5, FOXC1, BCL6, FOXO3, SMAD1 81 331 13588 2.5340345380627354 1.0 0.5035187029159459 89.43984454174753 Annotation Cluster 51 Enrichment Score: 1.1970092924047055 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000902~cell morphogenesis 6 7.4074074074074066 0.0354997634339479 HIF1A, CREB1, BCL6, SOX6, PROX1, NFATC1 81 309 13588 3.2573414838787005 1.0 0.18891301547923067 43.96536008600091 GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 6 7.4074074074074066 0.055874750044614584 HIF1A, CREB1, BCL6, SOX6, PROX1, NFATC1 81 351 13588 2.867574126833386 1.0 0.2737101331109574 60.20138004062628 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 4 4.938271604938271 0.12927991874733424 HIF1A, CREB1, PROX1, NFATC1 81 212 13588 3.165152573957605 1.0 0.5004442127690163 89.12076385633436 Annotation Cluster 52 Enrichment Score: 1.0157622995385933 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_pdgfPathway:PDGF Signaling Pathway 4 4.938271604938271 0.05903592974242851 JUN, STAT1, SRF, STAT3 39 28 1171 4.289377289377289 0.9985129849969534 0.5149206167702015 49.540263164792165 BIOCARTA m_egfPathway:EGF Signaling Pathway 4 4.938271604938271 0.05903592974242851 JUN, STAT1, SRF, STAT3 39 28 1171 4.289377289377289 0.9985129849969534 0.5149206167702015 49.540263164792165 BIOCARTA m_il6Pathway:IL 6 signaling pathway 3 3.7037037037037033 0.14639833731113988 JUN, SRF, STAT3 39 21 1171 4.28937728937729 0.9999999559128523 0.7017408921602737 83.1240812231581 BIOCARTA m_TPOPathway:TPO Signaling Pathway 3 3.7037037037037033 0.16950473836425906 JUN, STAT1, STAT3 39 23 1171 3.9163879598662206 0.9999999976607534 0.734169341483476 87.60344982226633 Annotation Cluster 53 Enrichment Score: 0.9378063954191769 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031399~regulation of protein modification process 4 4.938271604938271 0.07345097178267876 TRP53, JUN, SMAD4, ARNT 81 165 13588 4.066741488963711 1.0 0.33769600418590684 70.54963411937868 GOTERM_BP_FAT GO:0031401~positive regulation of protein modification process 3 3.7037037037037033 0.07717883212171096 TRP53, SMAD4, ARNT 81 78 13588 6.452041785375118 1.0 0.34793262843105566 72.39202795984485 GOTERM_BP_FAT GO:0032270~positive regulation of cellular protein metabolic process 3 3.7037037037037033 0.11730682374194745 TRP53, SMAD4, ARNT 81 100 13588 5.032592592592592 1.0 0.4680617923662268 86.45928383589485 GOTERM_BP_FAT GO:0051247~positive regulation of protein metabolic process 3 3.7037037037037033 0.13496998076533795 TRP53, SMAD4, ARNT 81 109 13588 4.617057424396873 1.0 0.5103659382953571 90.20574920093605 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 4 4.938271604938271 0.22798790750696077 TRP53, JUN, SMAD4, ARNT 81 280 13588 2.39647266313933 1.0 0.6974188073059706 98.41780732003583 Annotation Cluster 54 Enrichment Score: 0.6687374195671567 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016568~chromatin modification 4 4.938271604938271 0.1622121142698754 HOPX, PBRM1, NR3C1, RERE 81 236 13588 2.843272651182256 1.0 0.5738271645991426 94.13483240155644 GOTERM_BP_FAT GO:0051276~chromosome organization 5 6.172839506172839 0.21442251025163817 TRP53, HOPX, PBRM1, NR3C1, RERE 81 404 13588 2.076152059650409 1.0 0.6750956192051065 97.90838504361417 GOTERM_BP_FAT GO:0006325~chromatin organization 4 4.938271604938271 0.28342234066816574 HOPX, PBRM1, NR3C1, RERE 81 315 13588 2.1301979227905155 1.0 0.773370702388737 99.52059687207078 Annotation Cluster 55 Enrichment Score: 0.6252581423449839 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006954~inflammatory response 4 4.938271604938271 0.14680595853092326 HIF1A, SMAD1, MECOM, STAT3 81 225 13588 2.982277091906721 1.0 0.5362506024954936 92.14597612852576 GOTERM_BP_FAT GO:0006952~defense response 5 6.172839506172839 0.27058330322968 HIF1A, RELA, SMAD1, MECOM, STAT3 81 448 13588 1.8722442680776015 1.0 0.7574694802208748 99.36278359258664 GOTERM_BP_FAT GO:0009611~response to wounding 4 4.938271604938271 0.33510499062397037 HIF1A, SMAD1, MECOM, STAT3 81 347 13588 1.9337531575764044 1.0 0.8329317721087455 99.85553950424311 Annotation Cluster 56 Enrichment Score: 0.6251486286192746 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048878~chemical homeostasis 7 8.641975308641975 0.020496034773616473 TRP53, HIF1A, EPAS1, SMAD7, FOXO3, NCOR2, STAT3 81 365 13588 3.2171824792829358 0.9999999999119094 0.11945336477934676 28.240239189129433 GOTERM_BP_FAT GO:0019725~cellular homeostasis 4 4.938271604938271 0.3286298416242573 TRP53, HIF1A, SMAD7, SRF 81 343 13588 1.956304214807616 1.0 0.8268747368765827 99.83126911834155 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 3 3.7037037037037033 0.4565952058578309 TRP53, HIF1A, SMAD7 81 261 13588 1.9281963956293455 1.0 0.9288456125337239 99.99430426918671 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 3 3.7037037037037033 0.4703053226495021 TRP53, HIF1A, SMAD7 81 268 13588 1.8778330569375343 1.0 0.9356233602449822 99.9962180610745 GOTERM_BP_FAT GO:0050801~ion homeostasis 3 3.7037037037037033 0.5175696112456923 TRP53, HIF1A, SMAD7 81 293 13588 1.7176083933763113 1.0 0.9548875542286485 99.99915418667288 Annotation Cluster 57 Enrichment Score: 0.617610004649978 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016477~cell migration 4 4.938271604938271 0.16793366684550964 HIF1A, FOXC1, NR2F2, SRF 81 240 13588 2.7958847736625514 1.0 0.5861001889153612 94.74478841986587 GOTERM_BP_FAT GO:0048870~cell motility 4 4.938271604938271 0.234221137031962 HIF1A, FOXC1, NR2F2, SRF 81 284 13588 2.3627195270387755 1.0 0.7070590161515679 98.61055197684973 GOTERM_BP_FAT GO:0051674~localization of cell 4 4.938271604938271 0.234221137031962 HIF1A, FOXC1, NR2F2, SRF 81 284 13588 2.3627195270387755 1.0 0.7070590161515679 98.61055197684973 GOTERM_BP_FAT GO:0006928~cell motion 4 4.938271604938271 0.36742613176096867 HIF1A, FOXC1, NR2F2, SRF 81 367 13588 1.8283715141117503 1.0 0.8636060110649939 99.93499379004763 Annotation Cluster 58 Enrichment Score: 0.5272039327872775 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044427~chromosomal part 4 4.938271604938271 0.07612231889253174 ATRX, TRP53, PBRM1, FOXC1 40 318 12504 3.9320754716981132 0.9374097557081342 0.2927656746610937 50.40635268648098 GOTERM_CC_FAT GO:0005694~chromosome 4 4.938271604938271 0.11296800543167707 ATRX, TRP53, PBRM1, FOXC1 40 378 12504 3.307936507936508 0.9849382662054069 0.3426638803928549 65.41674207988729 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 4 4.938271604938271 0.9513895989054255 ATRX, TRP53, PBRM1, FOXC1 40 1919 12504 0.6515893694632621 1.0 0.9999337156341999 99.9999999997669 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 4 4.938271604938271 0.9513895989054255 ATRX, TRP53, PBRM1, FOXC1 40 1919 12504 0.6515893694632621 1.0 0.9999337156341999 99.9999999997669 Annotation Cluster 59 Enrichment Score: 0.46405141154277346 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 3 3.7037037037037033 0.2536232702011465 BCL6, PROX1, SRF 81 165 13588 3.050056116722783 1.0 0.7353751210205711 99.07902599587976 GOTERM_BP_FAT GO:0030029~actin filament-based process 3 3.7037037037037033 0.2776650615305035 BCL6, PROX1, SRF 81 176 13588 2.8594276094276094 1.0 0.7665041768865011 99.45500703284162 GOTERM_BP_FAT GO:0007010~cytoskeleton organization 3 3.7037037037037033 0.5756194116477662 BCL6, PROX1, SRF 81 326 13588 1.5437400590774824 1.0 0.9731125470498461 99.99989159298354 Annotation Cluster 60 Enrichment Score: 0.027074390533490648 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 3 3.7037037037037033 0.8962798609491576 SMAD7, CREB1, SMAD2 81 640 13588 0.7863425925925925 1.0 0.999921560766795 99.99999999999997 GOTERM_BP_FAT GO:0016310~phosphorylation 3 3.7037037037037033 0.9295618770880801 SMAD7, CREB1, SMAD2 81 718 13588 0.7009181883833694 1.0 0.9999837319719637 100.0 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 3 3.7037037037037033 0.9671420088597696 SMAD7, CREB1, SMAD2 81 866 13588 0.5811307843640406 1.0 0.9999992406186051 100.0 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 3 3.7037037037037033 0.9671420088597696 SMAD7, CREB1, SMAD2 81 866 13588 0.5811307843640406 1.0 0.9999992406186051 100.0