Annotation Cluster 1,Enrichment Score: 5.60,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
SP_PIR_KEYWORDS,glycoprotein,22,62.86,9.45E-07,"A2M, NRG3, PTGS2, SPOCK3, COL21A1, IL21R, CHI3L1, GPR68, EPHB1, NPTX1, UNC5B, EREG, PTGDS, ITGA8, ST8SIA4, AREG, GPNMB, SLITRK5, IL1A, ANGPTL4, CDH23, SPP1",2.8
SP_PIR_KEYWORDS,signal,19,54.29,1.68E-06,"A2M, COL21A1, SPOCK3, PTGS2, IL21R, CHI3L1, EPHB1, NPTX1, UNC5B, EREG, PTGDS, HTRA1, ITGA8, AREG, GPNMB, SLITRK5, ANGPTL4, CDH23, SPP1",3.21
UP_SEQ_FEATURE,signal peptide,19,54.29,1.85E-06,"A2M, COL21A1, SPOCK3, PTGS2, IL21R, CHI3L1, EPHB1, NPTX1, UNC5B, EREG, PTGDS, HTRA1, ITGA8, AREG, GPNMB, SLITRK5, ANGPTL4, CDH23, SPP1",3.19
UP_SEQ_FEATURE,glycosylation site:N-linked (GlcNAc...),20,57.14,1.34E-05,"A2M, PTGS2, COL21A1, IL21R, CHI3L1, GPR68, EPHB1, NPTX1, UNC5B, EREG, PTGDS, ST8SIA4, ITGA8, AREG, GPNMB, SLITRK5, IL1A, ANGPTL4, CDH23, SPP1",2.65
,,,,,,
Annotation Cluster 2,Enrichment Score: 3.53,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_CC_FAT,GO:0044421~extracellular region part,11,31.43,5.62E-05,"A2M, SPOCK3, EREG, COL21A1, HTRA1, HMOX1, CHI3L1, AREG, IL1A, SPP1, ANGPTL4",4.58
GOTERM_CC_FAT,GO:0005615~extracellular space,9,25.71,1.71E-04,"A2M, EREG, HTRA1, HMOX1, CHI3L1, AREG, IL1A, SPP1, ANGPTL4",5.25
SP_PIR_KEYWORDS,Secreted,11,31.43,4.87E-04,"A2M, NRG3, SPOCK3, PTGDS, EREG, COL21A1, HTRA1, CHI3L1, IL1A, SPP1, ANGPTL4",3.58
GOTERM_CC_FAT,GO:0005576~extracellular region,13,37.14,0.00167085,"A2M, NRG3, EREG, SPOCK3, PTGDS, COL21A1, HTRA1, HMOX1, CHI3L1, AREG, IL1A, SPP1, ANGPTL4",2.58
,,,,,,
Annotation Cluster 3,Enrichment Score: 2.04,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
UP_SEQ_FEATURE,domain:EGF-like,4,11.43,3.31E-04,"NRG3, PTGS2, EREG, AREG",28.74
INTERPRO,IPR006209:EGF,4,11.43,0.002178715,"NRG3, PTGS2, EREG, AREG",14.99
INTERPRO,"IPR013032:EGF-like region, conserved site",5,14.29,0.002869069,"NRG3, PTGS2, EREG, AREG, EPHB1",8.12
INTERPRO,"IPR000742:EGF-like, type 3",4,11.43,0.007135808,"NRG3, PTGS2, EREG, AREG",9.81
INTERPRO,IPR006210:EGF-like,4,11.43,0.007864235,"NRG3, PTGS2, EREG, AREG",9.47
SMART,SM00181:EGF,4,11.43,0.013660722,"NRG3, PTGS2, EREG, AREG",7.53
SP_PIR_KEYWORDS,growth factor,3,8.57,0.022399877,"NRG3, EREG, AREG",12.59
KEGG_PATHWAY,hsa04012:ErbB signaling pathway,3,8.57,0.033318528,"NRG3, EREG, AREG",9.74
GOTERM_MF_FAT,GO:0008083~growth factor activity,3,8.57,0.053008865,"NRG3, EREG, AREG",7.8
SP_PIR_KEYWORDS,egf-like domain,3,8.57,0.062196648,"NRG3, EREG, AREG",7.17
,,,,,,
Annotation Cluster 4,Enrichment Score: 1.863512985220115,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0048667~cell morphogenesis involved in neuron differentiation,5,14.29,0.001594344,"UNC5B, NR4A2, SLITRK5, EPHB1, CDH23",9.52
GOTERM_BP_FAT,GO:0030030~cell projection organization,6,17.14,0.001837071,"UNC5B, ITGA8, NR4A2, SLITRK5, EPHB1, CDH23",6.49
GOTERM_BP_FAT,GO:0000904~cell morphogenesis involved in differentiation,5,14.29,0.002801246,"UNC5B, NR4A2, SLITRK5, EPHB1, CDH23",8.15
GOTERM_BP_FAT,GO:0048666~neuron development,5,14.29,0.008935171,"UNC5B, NR4A2, SLITRK5, EPHB1, CDH23",5.87
GOTERM_BP_FAT,GO:0000902~cell morphogenesis,5,14.29,0.010565106,"UNC5B, NR4A2, SLITRK5, EPHB1, CDH23",5.59
GOTERM_BP_FAT,GO:0007409~axonogenesis,4,11.43,0.01138953,"UNC5B, NR4A2, SLITRK5, EPHB1",8.25
GOTERM_BP_FAT,GO:0048812~neuron projection morphogenesis,4,11.43,0.014836101,"UNC5B, NR4A2, SLITRK5, EPHB1",7.47
GOTERM_BP_FAT,GO:0032989~cellular component morphogenesis,5,14.29,0.01526274,"UNC5B, NR4A2, SLITRK5, EPHB1, CDH23",5.01
GOTERM_BP_FAT,GO:0030182~neuron differentiation,5,14.29,0.021118162,"UNC5B, NR4A2, SLITRK5, EPHB1, CDH23",4.54
GOTERM_BP_FAT,GO:0048858~cell projection morphogenesis,4,11.43,0.02146135,"UNC5B, NR4A2, SLITRK5, EPHB1",6.5
GOTERM_BP_FAT,GO:0032990~cell part morphogenesis,4,11.43,0.024058782,"UNC5B, NR4A2, SLITRK5, EPHB1",6.22
GOTERM_BP_FAT,GO:0031175~neuron projection development,4,11.43,0.024058782,"UNC5B, NR4A2, SLITRK5, EPHB1",6.22
GOTERM_BP_FAT,GO:0006928~cell motion,4,11.43,0.108234862,"PTGS2, UNC5B, NR4A2, EPHB1",3.35
SP_PIR_KEYWORDS,receptor,6,17.14,0.143580865,"UNC5B, ITGA8, IL21R, NR4A2, GPR68, EPHB1",2.08
,,,,,,
Annotation Cluster 5,Enrichment Score: 1.6428367710355325,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0051240~positive regulation of multicellular organismal process,6,17.14,2.88E-04,"PTGS2, EREG, HMOX1, HEY2, IL1A, SPP1",9.78
GOTERM_BP_FAT,GO:0009991~response to extracellular stimulus,5,14.29,0.001923715,"A2M, PTGS2, HMOX1, NR4A2, SPP1",9.04
GOTERM_BP_FAT,GO:0007584~response to nutrient,4,11.43,0.004716281,"A2M, PTGS2, HMOX1, SPP1",11.37
GOTERM_BP_FAT,GO:0010033~response to organic substance,7,20,0.007234124,"DUSP4, A2M, CYP1B1, PTGS2, HMOX1, NR4A2, SPP1",3.86
GOTERM_BP_FAT,GO:0006954~inflammatory response,5,14.29,0.007724749,"A2M, HMOX1, GPR68, IL1A, SPP1",6.12
GOTERM_BP_FAT,GO:0009611~response to wounding,6,17.14,0.008669325,"A2M, EREG, HMOX1, GPR68, IL1A, SPP1",4.5
GOTERM_BP_FAT,GO:0048545~response to steroid hormone stimulus,4,11.43,0.011230968,"A2M, PTGS2, HMOX1, SPP1",8.29
GOTERM_BP_FAT,GO:0031667~response to nutrient levels,4,11.43,0.012036795,"A2M, PTGS2, HMOX1, SPP1",8.08
GOTERM_BP_FAT,GO:0010035~response to inorganic substance,4,11.43,0.01339419,"A2M, PTGS2, HMOX1, NR4A2",7.76
GOTERM_BP_FAT,GO:0009719~response to endogenous stimulus,5,14.29,0.016311742,"A2M, PTGS2, HMOX1, NR4A2, SPP1",4.91
GOTERM_BP_FAT,GO:0032101~regulation of response to external stimulus,3,8.57,0.057166574,"A2M, PTGS2, SPP1",7.51
GOTERM_BP_FAT,GO:0009725~response to hormone stimulus,4,11.43,0.059345806,"A2M, PTGS2, HMOX1, SPP1",4.34
GOTERM_BP_FAT,GO:0006952~defense response,5,14.29,0.061026868,"A2M, HMOX1, GPR68, IL1A, SPP1",3.23
GOTERM_CC_FAT,GO:0043233~organelle lumen,4,11.43,0.838160698,"DUSP4, A2M, PTGS2, HMOX1",0.88
GOTERM_CC_FAT,GO:0031974~membrane-enclosed lumen,4,11.43,0.848323491,"DUSP4, A2M, PTGS2, HMOX1",0.86
GOTERM_CC_FAT,GO:0070013~intracellular organelle lumen,3,8.57,0.942490047,"DUSP4, PTGS2, HMOX1",0.67
,,,,,,
Annotation Cluster 6,Enrichment Score: 1.602008973268918,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0051240~positive regulation of multicellular organismal process,6,17.14,2.88E-04,"PTGS2, EREG, HMOX1, HEY2, IL1A, SPP1",9.78
GOTERM_BP_FAT,GO:0008285~negative regulation of cell proliferation,5,14.29,0.011078985,"PTGS2, EREG, HMOX1, GPNMB, IL1A",5.51
GOTERM_BP_FAT,GO:0048514~blood vessel morphogenesis,4,11.43,0.014467659,"EREG, HMOX1, HEY2, ANGPTL4",7.54
GOTERM_BP_FAT,GO:0001568~blood vessel development,4,11.43,0.02146135,"EREG, HMOX1, HEY2, ANGPTL4",6.5
GOTERM_BP_FAT,GO:0001944~vasculature development,4,11.43,0.022857751,"EREG, HMOX1, HEY2, ANGPTL4",6.34
GOTERM_BP_FAT,GO:0042127~regulation of cell proliferation,6,17.14,0.040354954,"PTGS2, EREG, HMOX1, HEY2, GPNMB, IL1A",3.03
GOTERM_BP_FAT,GO:0010647~positive regulation of cell communication,4,11.43,0.04544004,"PTGS2, EREG, HMOX1, ITGA8",4.84
SP_PIR_KEYWORDS,developmental protein,5,14.29,0.047311261,"UNC5B, EREG, ITGA8, HEY2, ANGPTL4",3.53
GOTERM_BP_FAT,GO:0001525~angiogenesis,3,8.57,0.050328427,"EREG, HMOX1, ANGPTL4",8.07
GOTERM_BP_FAT,GO:0045449~regulation of transcription,4,11.43,0.966398367,"EREG, HMOX1, HEY2, NR4A2",0.61
,,,,,,
Annotation Cluster 7,Enrichment Score: 1.5794533421188164,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
SP_PIR_KEYWORDS,extracellular matrix,4,11.43,0.008729669,"SPOCK3, COL21A1, SPP1, ANGPTL4",9.12
GOTERM_CC_FAT,GO:0005578~proteinaceous extracellular matrix,4,11.43,0.041679775,"SPOCK3, COL21A1, CHI3L1, ANGPTL4",4.99
GOTERM_CC_FAT,GO:0031012~extracellular matrix,4,11.43,0.050201513,"SPOCK3, COL21A1, CHI3L1, ANGPTL4",4.63
,,,,,,
Annotation Cluster 8,Enrichment Score: 1.5293916430233132,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0031214~biomineral formation,3,8.57,0.003643465,"PTGS2, GPNMB, SPP1",32.26
GOTERM_BP_FAT,GO:0001503~ossification,3,8.57,0.03186753,"PTGS2, GPNMB, SPP1",10.38
GOTERM_BP_FAT,GO:0060348~bone development,3,8.57,0.036040091,"PTGS2, GPNMB, SPP1",9.7
GOTERM_BP_FAT,GO:0001501~skeletal system development,3,8.57,0.182299107,"PTGS2, GPNMB, SPP1",3.74
,,,,,,
Annotation Cluster 9,Enrichment Score: 1.419569935014222,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0051240~positive regulation of multicellular organismal process,6,17.14,2.88E-04,"PTGS2, EREG, HMOX1, HEY2, IL1A, SPP1",9.78
GOTERM_BP_FAT,GO:0042108~positive regulation of cytokine biosynthetic process,3,8.57,0.00606855,"EREG, HMOX1, IL1A",24.87
GOTERM_BP_FAT,GO:0008285~negative regulation of cell proliferation,5,14.29,0.011078985,"PTGS2, EREG, HMOX1, GPNMB, IL1A",5.51
GOTERM_BP_FAT,GO:0042035~regulation of cytokine biosynthetic process,3,8.57,0.013969307,"EREG, HMOX1, IL1A",16.13
GOTERM_BP_FAT,GO:0042127~regulation of cell proliferation,6,17.14,0.040354954,"PTGS2, EREG, HMOX1, HEY2, GPNMB, IL1A",3.03
GOTERM_BP_FAT,GO:0010647~positive regulation of cell communication,4,11.43,0.04544004,"PTGS2, EREG, HMOX1, ITGA8",4.84
GOTERM_BP_FAT,GO:0001817~regulation of cytokine production,3,8.57,0.071743582,"EREG, HMOX1, IL1A",6.59
GOTERM_BP_FAT,GO:0010557~positive regulation of macromolecule biosynthetic process,5,14.29,0.073106809,"EREG, HMOX1, NR4A2, AREG, IL1A",3.04
GOTERM_BP_FAT,GO:0031328~positive regulation of cellular biosynthetic process,5,14.29,0.083535121,"EREG, HMOX1, NR4A2, AREG, IL1A",2.9
GOTERM_BP_FAT,GO:0009891~positive regulation of biosynthetic process,5,14.29,0.08705191,"EREG, HMOX1, NR4A2, AREG, IL1A",2.86
GOTERM_BP_FAT,GO:0008283~cell proliferation,4,11.43,0.089090904,"EREG, HMOX1, AREG, IL1A",3.65
GOTERM_BP_FAT,GO:0010604~positive regulation of macromolecule metabolic process,5,14.29,0.153582903,"EREG, HMOX1, NR4A2, AREG, IL1A",2.32
GOTERM_BP_FAT,GO:0051726~regulation of cell cycle,3,8.57,0.192899581,"PTGS2, EREG, IL1A",3.61
GOTERM_BP_FAT,GO:0008284~positive regulation of cell proliferation,3,8.57,0.267903173,"PTGS2, EREG, HEY2",2.88
,,,,,,
Annotation Cluster 10,Enrichment Score: 1.227623685880425,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
UP_SEQ_FEATURE,short sequence motif:Cell attachment site,3,8.57,0.010685501,"ITGA8, GPNMB, SPP1",18.62
GOTERM_BP_FAT,GO:0007155~cell adhesion,6,17.14,0.026074115,"COL21A1, ITGA8, GPNMB, CLDN14, SPP1, CDH23",3.41
GOTERM_BP_FAT,GO:0022610~biological adhesion,6,17.14,0.026216004,"COL21A1, ITGA8, GPNMB, CLDN14, SPP1, CDH23",3.41
GOTERM_BP_FAT,GO:0016337~cell-cell adhesion,3,8.57,0.145241867,"ITGA8, CLDN14, CDH23",4.32
SP_PIR_KEYWORDS,cell adhesion,3,8.57,0.170809008,"ITGA8, SPP1, CDH23",3.91
GOTERM_CC_FAT,GO:0042995~cell projection,4,11.43,0.23773018,"ITGA8, CYGB, SPP1, CDH23",2.29
,,,,,,
Annotation Cluster 11,Enrichment Score: 1.2041485654162651,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
UP_SEQ_FEATURE,topological domain:Extracellular,12,34.29,0.005771659,"NRG3, UNC5B, EREG, SLC16A6, ITGA8, IL21R, GPR68, GPNMB, SLITRK5, CLDN14, EPHB1, CDH23",2.41
UP_SEQ_FEATURE,topological domain:Cytoplasmic,13,37.14,0.010601826,"NRG3, UNC5B, EREG, SLC16A6, ST8SIA4, ITGA8, IL21R, GPR68, GPNMB, SLITRK5, CLDN14, EPHB1, CDH23",2.1
SP_PIR_KEYWORDS,membrane,19,54.29,0.01085661,"CYP1B1, NRG3, PTGS2, IL21R, GPR68, EPHB1, CLDN14, RDH10, UNC5B, EREG, PTGDS, SLC16A6, ITGA8, ST8SIA4, AREG, GPNMB, RAB27B, SLITRK5, CDH23",1.67
UP_SEQ_FEATURE,transmembrane region,15,42.86,0.034957459,"NRG3, IL21R, GPR68, EPHB1, CLDN14, RDH10, UNC5B, EREG, SLC16A6, ITGA8, ST8SIA4, AREG, GPNMB, SLITRK5, CDH23",1.67
SP_PIR_KEYWORDS,transmembrane,15,42.86,0.036727724,"NRG3, IL21R, GPR68, EPHB1, CLDN14, RDH10, UNC5B, EREG, SLC16A6, ITGA8, ST8SIA4, AREG, GPNMB, SLITRK5, CDH23",1.66
GOTERM_CC_FAT,GO:0005887~integral to plasma membrane,7,20,0.062565645,"NRG3, EREG, SLC16A6, ITGA8, GPR68, GPNMB, EPHB1",2.35
GOTERM_CC_FAT,GO:0031226~intrinsic to plasma membrane,7,20,0.068364757,"NRG3, EREG, SLC16A6, ITGA8, GPR68, GPNMB, EPHB1",2.3
GOTERM_CC_FAT,GO:0044459~plasma membrane part,10,28.57,0.072657422,"NRG3, PTGS2, EREG, SLC16A6, HMOX1, ITGA8, GPR68, GPNMB, CLDN14, EPHB1",1.81
GOTERM_CC_FAT,GO:0005886~plasma membrane,12,34.29,0.292352387,"NRG3, PTGS2, EREG, SLC16A6, HMOX1, ITGA8, GPR68, GPNMB, BMF, CLDN14, EPHB1, CDH23",1.27
GOTERM_CC_FAT,GO:0031224~intrinsic to membrane,16,45.71,0.329590732,"NRG3, IL21R, GPR68, EPHB1, CLDN14, RDH10, UNC5B, EREG, SLC16A6, ITGA8, ST8SIA4, AREG, GPNMB, RAB27B, SLITRK5, CDH23",1.17
SP_PIR_KEYWORDS,cell membrane,6,17.14,0.345597147,"NRG3, EREG, SLC16A6, GPR68, CLDN14, CDH23",1.5
GOTERM_CC_FAT,GO:0016021~integral to membrane,15,42.86,0.402168295,"NRG3, IL21R, GPR68, EPHB1, CLDN14, RDH10, UNC5B, EREG, SLC16A6, ITGA8, ST8SIA4, AREG, GPNMB, SLITRK5, CDH23",1.13
,,,,,,
Annotation Cluster 12,Enrichment Score: 1.1910485199478116,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
SP_PIR_KEYWORDS,microsome,4,11.43,8.60E-04,"RDH10, CYP1B1, PTGS2, HMOX1",20.74
SP_PIR_KEYWORDS,heme,4,11.43,0.001260237,"CYP1B1, PTGS2, HMOX1, CYGB",18.17
GOTERM_MF_FAT,GO:0020037~heme binding,4,11.43,0.002668168,"CYP1B1, PTGS2, HMOX1, CYGB",13.84
GOTERM_MF_FAT,GO:0046906~tetrapyrrole binding,4,11.43,0.003198225,"CYP1B1, PTGS2, HMOX1, CYGB",12.99
UP_SEQ_FEATURE,metal ion-binding site:Iron (heme axial ligand),3,8.57,0.013121555,"CYP1B1, PTGS2, HMOX1",16.72
SP_PIR_KEYWORDS,iron,4,11.43,0.013723617,"CYP1B1, PTGS2, HMOX1, CYGB",7.71
GOTERM_CC_FAT,GO:0005792~microsome,4,11.43,0.019303912,"RDH10, CYP1B1, PTGS2, HMOX1",6.74
GOTERM_CC_FAT,GO:0042598~vesicular fraction,4,11.43,0.020835034,"RDH10, CYP1B1, PTGS2, HMOX1",6.55
GOTERM_MF_FAT,GO:0005506~iron ion binding,4,11.43,0.033468638,"CYP1B1, PTGS2, HMOX1, CYGB",5.44
SP_PIR_KEYWORDS,endoplasmic reticulum,5,14.29,0.035990404,"RDH10, CYP1B1, PTGS2, PTGDS, HMOX1",3.85
GOTERM_BP_FAT,GO:0006979~response to oxidative stress,3,8.57,0.060377496,"PTGS2, HMOX1, CYGB",7.28
SP_PIR_KEYWORDS,oxidoreductase,4,11.43,0.076165866,"RDH10, CYP1B1, PTGS2, HMOX1",3.91
GOTERM_CC_FAT,GO:0005783~endoplasmic reticulum,6,17.14,0.078955976,"RDH10, CYP1B1, PTGS2, PTGDS, HMOX1, CLDN14",2.5
GOTERM_CC_FAT,GO:0005624~membrane fraction,5,14.29,0.129697357,"RDH10, CYP1B1, PTGS2, SLC16A6, HMOX1",2.47
GOTERM_CC_FAT,GO:0005626~insoluble fraction,5,14.29,0.142793809,"RDH10, CYP1B1, PTGS2, SLC16A6, HMOX1",2.38
SP_PIR_KEYWORDS,calcium,4,11.43,0.167975183,"NPTX1, SPOCK3, ITGA8, CDH23",2.74
GOTERM_BP_FAT,GO:0050877~neurological system process,6,17.14,0.168024915,"RDH10, NPTX1, CYP1B1, PTGS2, ITGA8, CDH23",1.97
GOTERM_BP_FAT,GO:0050890~cognition,5,14.29,0.178298787,"RDH10, CYP1B1, PTGS2, ITGA8, CDH23",2.19
GOTERM_BP_FAT,GO:0055114~oxidation reduction,4,11.43,0.203062918,"RDH10, CYP1B1, PTGS2, HMOX1",2.49
GOTERM_CC_FAT,GO:0000267~cell fraction,5,14.29,0.265812837,"RDH10, CYP1B1, PTGS2, SLC16A6, HMOX1",1.84
GOTERM_MF_FAT,GO:0005509~calcium ion binding,4,11.43,0.357870994,"NPTX1, SPOCK3, ITGA8, CDH23",1.82
SP_PIR_KEYWORDS,metal-binding,6,17.14,0.620575622,"NPTX1, CYP1B1, PTGS2, HMOX1, NR4A2, CYGB",1.11
GOTERM_MF_FAT,GO:0043169~cation binding,10,28.57,0.667282454,"NPTX1, CYP1B1, PTGS2, SPOCK3, HMOX1, ITGA8, NR4A2, CHI3L1, CYGB, CDH23",1
GOTERM_MF_FAT,GO:0043167~ion binding,10,28.57,0.687308928,"NPTX1, CYP1B1, PTGS2, SPOCK3, HMOX1, ITGA8, NR4A2, CHI3L1, CYGB, CDH23",0.99
GOTERM_MF_FAT,GO:0046872~metal ion binding,9,25.71,0.788526236,"NPTX1, CYP1B1, PTGS2, SPOCK3, HMOX1, ITGA8, NR4A2, CYGB, CDH23",0.91
GOTERM_MF_FAT,GO:0046914~transition metal ion binding,5,14.29,0.911381315,"CYP1B1, PTGS2, HMOX1, NR4A2, CYGB",0.75
,,,,,,
Annotation Cluster 13,Enrichment Score: 1.057537044073436,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
INTERPRO,"IPR013032:EGF-like region, conserved site",5,14.29,0.002869069,"NRG3, PTGS2, EREG, AREG, EPHB1",8.12
GOTERM_BP_FAT,GO:0007169~transmembrane receptor protein tyrosine kinase signaling pathway,3,8.57,0.103196418,"EREG, AREG, EPHB1",5.33
GOTERM_BP_FAT,GO:0007267~cell-cell signaling,4,11.43,0.178797344,"NPTX1, EREG, AREG, EPHB1",2.65
GOTERM_BP_FAT,GO:0007167~enzyme linked receptor protein signaling pathway,3,8.57,0.202692693,"EREG, AREG, EPHB1",3.49
GOTERM_BP_FAT,GO:0007166~cell surface receptor linked signal transduction,6,17.14,0.480518459,"EREG, ITGA8, HEY2, GPR68, AREG, EPHB1",1.29
,,,,,,
Annotation Cluster 14,Enrichment Score: 1.0306484495007595,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0045765~regulation of angiogenesis,3,8.57,0.010270467,"HMOX1, IL1A, ANGPTL4",18.95
GOTERM_BP_FAT,GO:0001666~response to hypoxia,3,8.57,0.042102086,"HMOX1, NR4A2, ANGPTL4",8.91
GOTERM_BP_FAT,GO:0042981~regulation of apoptosis,6,17.14,0.043616584,"PTGS2, HMOX1, NR4A2, BMF, IL1A, ANGPTL4",2.97
GOTERM_BP_FAT,GO:0043067~regulation of programmed cell death,6,17.14,0.045206099,"PTGS2, HMOX1, NR4A2, BMF, IL1A, ANGPTL4",2.94
GOTERM_BP_FAT,GO:0010941~regulation of cell death,6,17.14,0.045811222,"PTGS2, HMOX1, NR4A2, BMF, IL1A, ANGPTL4",2.93
GOTERM_BP_FAT,GO:0070482~response to oxygen levels,3,8.57,0.046146147,"HMOX1, NR4A2, ANGPTL4",8.47
GOTERM_BP_FAT,GO:0043066~negative regulation of apoptosis,4,11.43,0.054381904,"HMOX1, NR4A2, IL1A, ANGPTL4",4.5
GOTERM_BP_FAT,GO:0043069~negative regulation of programmed cell death,4,11.43,0.056266012,"HMOX1, NR4A2, IL1A, ANGPTL4",4.43
GOTERM_BP_FAT,GO:0060548~negative regulation of cell death,4,11.43,0.056646609,"HMOX1, NR4A2, IL1A, ANGPTL4",4.42
GOTERM_BP_FAT,GO:0010557~positive regulation of macromolecule biosynthetic process,5,14.29,0.073106809,"EREG, HMOX1, NR4A2, AREG, IL1A",3.04
GOTERM_BP_FAT,GO:0031328~positive regulation of cellular biosynthetic process,5,14.29,0.083535121,"EREG, HMOX1, NR4A2, AREG, IL1A",2.9
GOTERM_BP_FAT,GO:0009891~positive regulation of biosynthetic process,5,14.29,0.08705191,"EREG, HMOX1, NR4A2, AREG, IL1A",2.86
GOTERM_BP_FAT,GO:0016265~death,5,14.29,0.097662393,"UNC5B, HMOX1, NR4A2, BMF, IL1A",2.75
GOTERM_BP_FAT,GO:0010604~positive regulation of macromolecule metabolic process,5,14.29,0.153582903,"EREG, HMOX1, NR4A2, AREG, IL1A",2.32
GOTERM_BP_FAT,GO:0008219~cell death,4,11.43,0.255083702,"UNC5B, HMOX1, BMF, IL1A",2.21
GOTERM_BP_FAT,GO:0006915~apoptosis,3,8.57,0.435357094,"UNC5B, BMF, IL1A",1.98
GOTERM_BP_FAT,GO:0012501~programmed cell death,3,8.57,0.442963325,"UNC5B, BMF, IL1A",1.95
GOTERM_BP_FAT,"GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process",3,8.57,0.453857636,"EREG, NR4A2, AREG",1.91
GOTERM_BP_FAT,GO:0051173~positive regulation of nitrogen compound metabolic process,3,8.57,0.470396368,"EREG, NR4A2, AREG",1.85
,,,,,,
Annotation Cluster 15,Enrichment Score: 1.0245389982940498,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_CC_FAT,GO:0031988~membrane-bounded vesicle,5,14.29,0.04694897,"A2M, NPTX1, GPNMB, RAB27B, SPP1",3.52
GOTERM_CC_FAT,GO:0030141~secretory granule,3,8.57,0.070274798,"A2M, NPTX1, RAB27B",6.66
GOTERM_CC_FAT,GO:0031982~vesicle,5,14.29,0.076769449,"A2M, NPTX1, GPNMB, RAB27B, SPP1",2.98
GOTERM_CC_FAT,GO:0016023~cytoplasmic membrane-bounded vesicle,4,11.43,0.147041551,"A2M, NPTX1, GPNMB, RAB27B",2.91
GOTERM_CC_FAT,GO:0031410~cytoplasmic vesicle,4,11.43,0.202418794,"A2M, NPTX1, GPNMB, RAB27B",2.49
,,,,,,
Annotation Cluster 16,Enrichment Score: 0.7547873535151811,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0050953~sensory perception of light stimulus,3,8.57,0.097083769,"RDH10, CYP1B1, CDH23",5.53
GOTERM_BP_FAT,GO:0007601~visual perception,3,8.57,0.097083769,"RDH10, CYP1B1, CDH23",5.53
GOTERM_BP_FAT,GO:0050877~neurological system process,6,17.14,0.168024915,"RDH10, NPTX1, CYP1B1, PTGS2, ITGA8, CDH23",1.97
GOTERM_BP_FAT,GO:0050890~cognition,5,14.29,0.178298787,"RDH10, CYP1B1, PTGS2, ITGA8, CDH23",2.19
GOTERM_BP_FAT,GO:0007600~sensory perception,3,8.57,0.596002252,"RDH10, CYP1B1, CDH23",1.47
,,,,,,
Annotation Cluster 17,Enrichment Score: 0.3422275395686978,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_CC_FAT,GO:0012505~endomembrane system,4,11.43,0.294308756,"CYP1B1, PTGDS, ST8SIA4, RAB27B",2.04
GOTERM_CC_FAT,GO:0031090~organelle membrane,4,11.43,0.503544562,"CYP1B1, PTGDS, ST8SIA4, RAB27B",1.46
GOTERM_CC_FAT,GO:0005794~Golgi apparatus,3,8.57,0.634565254,"PTGDS, ST8SIA4, RAB27B",1.37
,,,,,,
Annotation Cluster 18,Enrichment Score: 0.08377560639729016,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_BP_FAT,GO:0006357~regulation of transcription from RNA polymerase II promoter,3,8.57,0.535918388,"HMOX1, HEY2, NR4A2",1.64
GOTERM_BP_FAT,"GO:0006355~regulation of transcription, DNA-dependent",3,8.57,0.94224714,"HMOX1, HEY2, NR4A2",0.67
GOTERM_BP_FAT,GO:0051252~regulation of RNA metabolic process,3,8.57,0.94727898,"HMOX1, HEY2, NR4A2",0.66
GOTERM_BP_FAT,GO:0045449~regulation of transcription,4,11.43,0.966398367,"EREG, HMOX1, HEY2, NR4A2",0.61
,,,,,,
Annotation Cluster 19,Enrichment Score: 0.07,,,,,
Category,Term,Count,%,PValue,Genes,Fold Enrichment
GOTERM_CC_FAT,GO:0044430~cytoskeletal part,3,8.57,0.683127497,"ITGA8, BMF, CDH23",1.26
GOTERM_CC_FAT,GO:0005856~cytoskeleton,3,8.57,0.862972581,"ITGA8, BMF, CDH23",0.87
GOTERM_CC_FAT,GO:0043232~intracellular non-membrane-bounded organelle,4,11.43,0.965816735,"HMOX1, ITGA8, BMF, CDH23",0.62
GOTERM_CC_FAT,GO:0043228~non-membrane-bounded organelle,4,11.43,0.965816735,"HMOX1, ITGA8, BMF, CDH23",0.62