ID Description GeneRatio BgRatio pvalue ¡ªlg(P value) p.adjust qvalue geneID Count rno01100 Metabolic pathways 205 / 889 1300 / 7849 0.00000006 7.20 1.79E-05 1.64E-05 Acsl4/Acsl3/Ltc4s/Sc5d/Asah2/Atp5g3/Plce1/Gale/Ggt1/Nat2/Aldh1a2/Inpp4b/Msmo1/Gcsh/Ehhadh/Adh7/Ipmk/Ada/Adh1/Ak1/Aldh1a1/Aldoc/Alpi/Comt/Gls/Glud1/Hmgcs2/Uxs1/Acsm2a/Pklr/Pla2g4a/Plcd1/Prps2/Glul/Pgam2/Cth/Hk1/Ampd3/Pc/Rgn/Hsd11b1/Coq7/Cox6a2/Gclc/Cycs/Aldh3a1/Pemt/Ptgds/Ptgis/Rpn1/Hmgcr/Aldh1a3/Impa2/Akr1b8/Shmt1/Mtmr4/Phospho1/Mtm1/Sdhc/Cryl1/Gpat4/Gmds/Cndp2/Aprt/Arg1/Ces1e/Sqle/Maoa/Hal/Ndufc2/Galnt18/Plcg2/Tm7sf2/Psat1/Mcee/Pla2g2c/Hoga1/Pank1/Man1a1/Hexb/Aoc3/Hpd/Hsd17b7/Prps1/Mgat3/Ckmt1b/Gpat2/Sptlc3/Ldhc/Aldh1a7/Cyp11a1/Pla2g2a/Aass/Atp6v0a4/Baat/Galnt7/St6galnac3/Atp6v0d2/Ndufb6/Agmat/B3galt6/Ndufa7/Polr3h/Acsbg2/C1galt1c1/B3gnt2/Csgalnact1/Mtmr7/Agpat5/Gcnt2/Acat2/Aldh3b1/Nsdhl/Rev3l/Qrsl1/Cmbl/Plch1/Acss2/Ak8/Pon3/Nt5c3a/Atp6v1b1/Acer2/Extl1/Galm/Galnt14/Lpin1/Adpgk/Pigb/Glb1/Pgk2/Cox8c/Gfpt2/P4ha2/Hgd/Sdsl/Polr3a/Galntl6/Cyp2r1/Mccc2/Gatb/Ndufa9/Pigh/Rdh11/St3gal1/Glce/Pgm3/Pigc/Inpp5a/Polr3k/Azin2/Alg9/Pigw/Agpat1/St6galnac6/Si/Xdh/Cps1/Rfk/LOC500959/Rpe/Agk/Cyp4a1/Acot1/Fasn/Tpo/Aox1/Enpp3/Nt5e/Phgdh/Slc33a1/Gcnt1/Tdo2/Oat/St3gal2/Bpnt1/C1galt1/Alas1/Cox6b2/Gapdhs/Ido1/Mthfd2/Ndufa4/Acot4/Gnpda1/Cyp2b15/Polr3g/B3galt2/Pcca/Cox11/Flad1/Galnt1/Hsd17b2/Hsd17b4/Bst1/Abat/Alox15/Impa1/Gda/Atp6ap1/Galnt5/Fdps/Hao2/Asah1/Atp6v0e1 205 rno00512 Mucin type O-Glycan biosynthesis 12 / 889 28 / 7849 0.00002237 4.65 0.00233481 0.002135231 Galnt18/Galnt7/C1galt1c1/Galnt14/Galntl6/B4galt5/St3gal1/Gcnt1/St3gal2/C1galt1/Galnt1/Galnt5 12 rno04974 Protein digestion and absorption 25 / 889 93 / 7849 0.00002484 4.60 0.00233481 0.002135231 Slc7a9/Atp1b2/Dpp4/Atp1b1/Col12a1/Col1a1/Col11a2/Col6a1/Slc3a1/Fxyd2/Slc8a1/Col15a1/Cela3b/Col7a1/Col14a1/Col22a1/Col6a6/Col6a2/Col4a3/Kcnk5/Pga5/Slc7a8/Col5a2/Col5a1/Kcnj13 25 rno00350 Tyrosine metabolism 13 / 889 39 / 7849 0.00022401 3.65 0.015792879 0.014442909 Adh7/Adh1/Comt/Aldh3a1/Aldh1a3/Maoa/Aoc3/Hpd/Aldh3b1/Hgd/Tpo/Aox1/Mif 13 rno00604 Glycosphingolipid biosynthesis - ganglio series 7 / 889 15 / 7849 0.00066121 3.18 0.037292487 0.034104738 Hexb/St6galnac3/Glb1/St3gal1/St6galnac6/Slc33a1/St3gal2 7 rno04610 Complement and coagulation cascades 18 / 889 73 / 7849 0.00102133 2.99 0.048002662 0.043899411 C7/Cfh/C1s/C2/C3/Fgb/Fgg/Klkb1/Kng2/Cd59/Plat/F7/Cfb/Serping1/C1r/C5/Cd55/Thbd 18 rno04146 Peroxisome 20 / 889 88 / 7849 0.00163415 2.79 0.065832742 0.060205382 Pecr/Acsl4/Acsl3/Ehhadh/Pxmp4/Pex2/Gstk1/Baat/Pex26/Abcd4/Slc25a17/Pex13/Nudt19/Pex7/Crat/Xdh/Hsd17b4/Pex3/Hao2/Hacl1 20 rno01200 Carbon metabolism 25 / 889 121 / 7849 0.00194958 2.71 0.068722562 0.062848181 Ehhadh/Aldoc/Glud1/Pklr/Prps2/Pgam2/Hk1/Pc/Rgn/Shmt1/Sdhc/Psat1/Mcee/Prps1/Acat2/Acss2/Adpgk/Pgk2/Sdsl/Cps1/LOC500959/Rpe/Phgdh/Pcca/Hao2 25 rno00982 Drug metabolism - cytochrome P450 17 / 889 72 / 7849 0.00231227 2.64 0.07245105 0.06625796 Adh7/Mgst1/Adh1/Gstm1/Gstp1/Fmo2/Fmo4/Aldh3a1/Aldh1a3/Maoa/Gstt2/Gstk1/Aldh3b1/Gsta3/Aox1/Gstm5/Fmo3 17 rno00260 "Glycine, serine and threonine metabolism" 11 / 889 40 / 7849 0.00386104 2.41 0.100620441 0.09201944 Gcsh/Pgam2/Cth/Gnmt/Shmt1/Maoa/Psat1/Aoc3/Sdsl/Phgdh/Alas1 11 rno00010 Glycolysis / Gluconeogenesis 16 / 889 70 / 7849 0.00433831 2.36 0.100620441 0.09201944 Adh7/Adh1/Aldoc/Pklr/Pgam2/Hk1/Aldh3a1/Aldh1a3/Ldhc/Aldh3b1/Acss2/Galm/Adpgk/Pgk2/LOC500959/Gapdhs 16 rno00100 Steroid biosynthesis 7 / 889 20 / 7849 0.00479141 2.32 0.100620441 0.09201944 Sc5d/Msmo1/Sqle/Tm7sf2/Hsd17b7/Nsdhl/Cyp2r1 7 rno04060 Cytokine-cytokine receptor interaction 38 / 889 220 / 7849 0.00495292 2.31 0.100620441 0.09201944 Vegfc/Bmpr2/Flt3/Il2rg/Egfr/Epo/Il1a/Met/Cxcl10/Pdgfrb/Cxcl12/Il4r/Ghr/Il13ra1/Tnfrsf11b/Faslg/Kdr/Tnfrsf1a/Tgfb3/Il2rb/Tnfrsf17/Ccl7/Il18/Ccl21/Ccl27/Ccl19/Tnfrsf14/Cxcl16/Cxcl13/Tnfrsf9/Tnfrsf25/Il20rb/Kitlg/Csf1/Tgfb2/Tgfbr2/Ackr3/Vegfb 38 rno05206 MicroRNAs in cancer 27 / 889 143 / 7849 0.00499534 2.30 0.100620441 0.09201944 Cdkn1a/Bmpr2/Cdc25b/Apc/Egfr/Gls/Kras/Met/Abcc1/Pdgfrb/Abcb1b/Pim1/Prkcg/Casp3/Slc7a1/Plcg2/Prkce/Slc45a3/Zfpm2/Rdx/Brca1/Ccnd2/Bcl2l11/Mmp16/Tgfb2/Vim/Hmga2 27 rno05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 16 / 889 74 / 7849 0.00764534 2.12 0.143732446 0.131446246 Lef1/Gja1/Itgb7/Itgb4/Dsc2/Slc8a1/Cacna2d3/Dsg2/Itgb6/Tcf7l1/Ctnna3/Des/Sgcb/Cacna1s/Ryr2/Itga7 16 rno00360 Phenylalanine metabolism 7 / 889 22 / 7849 0.00861502 2.06474372 0.151839725 0.138860518 Aldh3a1/Aldh1a3/Maoa/Aoc3/Hpd/Aldh3b1/Mif 7 rno00630 Glyoxylate and dicarboxylate metabolism 8 / 889 28 / 7849 0.01028562 1.98776937 0.16563808 0.151479394 Gcsh/Glul/Shmt1/Mcee/Hoga1/Acat2/Pcca/Hao2 8 rno01230 Biosynthesis of amino acids 17 / 889 83 / 7849 0.01057264 1.97581642 0.16563808 0.151479394 Aldoc/Pklr/Prps2/Glul/Pgam2/Cth/Pc/Shmt1/Arg1/Psat1/Prps1/Pgk2/Sdsl/Cps1/LOC500959/Rpe/Phgdh 17 rno04933 AGE-RAGE signaling pathway in diabetic complications 20 / 889 104 / 7849 0.01185850 1.92597027 0.167247531 0.15295127 Vegfc/Plce1/Agtr1a/Il1a/Kras/Pim1/Plcd1/Vcam1/Casp3/Icam1/Tgfb3/Plcg2/Prkce/Col1a1/Col4a3/Mmp2/Tgfb2/Tgfbr2/Thbd/Vegfb 20 rno04978 Mineral absorption 11 / 889 46 / 7849 0.01186153 1.92585940 0.167247531 0.15295127 Slc26a3/Atp1b2/Tf/Fth1/Atp1b1/Cybrd1/Fxyd2/Slc8a1/Steap1/Slc39a4/Slc46a1 11 rno00230 Purine metabolism 31 / 889 182 / 7849 0.01275556 1.89430046 0.171288951 0.15664723 Npr2/Pde9a/Ada/Ak1/Npr1/Pde4b/Pklr/Prps2/Ampd3/Aprt/Prps1/Pde1b/Polr3h/Pde6a/Ak8/Nt5c3a/Polr3a/Nudt5/Pde6d/Polr3k/Gucy1a3/Xdh/Enpp3/Nt5e/Fhit/Entpd2/Adcy5/Polr3g/LOC688828/Adcy2/Gda 31 rno05200 Pathways in cancer 59 / 889 400 / 7849 0.01883288 1.72508336 0.238440131 0.21805835 Vegfc/Cdkn1a/Wnt2b/Tpm3/Wnt11/Gli1/Flt3/Lef1/Fgf12/Agtr1a/Apc/Egfr/Kras/Met/Gng8/Pdgfrb/Prkcg/Ret/Cxcl12/Slc2a1/Tgfa/Ptger3/Arnt2/Bmp4/Cycs/Faslg/Casp3/Lamb2/Tgfb3/Fzd6/Cblc/Plcg2/Fgf18/Birc7/Mmp1b/Gli2/Lamb3/Plekhg5/Traf6/Tcf7l1/Tfg/Rasgrp2/Ctnna3/Col4a3/Lpar2/Kitlg/Gnb3/Adcy5/Birc3/Fgfr1/Adcy2/Mmp2/Tceb2/Tgfb2/Tgfbr2/Cdh1/Gnb5/Vegfb/Pgf 59 rno04270 Vascular smooth muscle contraction 22 / 889 123 / 7849 0.01944724 1.71114192 0.238440131 0.21805835 Npr2/Adra1b/Agtr1a/Npr1/Pla2g4a/Prkcg/Avpr1a/Adora2a/Ppp1cb/Cald1/Mylk3/Prkce/Pla2g2c/Pla2g2a/Mrvi1/Gucy1a3/Cyp4a1/Adcy5/Cacna1s/Adcy2/Prkch/Kcnma1 22 rno04972 Pancreatic secretion 18 / 889 97 / 7849 0.02314103 1.63561733 0.254822803 0.233040638 Slc26a3/Atp1b2/Prkcg/Cckar/Atp1b1/Pla2g2c/Atp2b3/Fxyd2/Pla2g2a/Cela3b/Clca4l/Adcy5/Ryr2/Bst1/Adcy2/Kcnma1/Slc4a4/Rab27b 18 rno00640 Propanoate metabolism 8 / 889 32 / 7849 0.02319343 1.63463495 0.254822803 0.233040638 Ehhadh/Mcee/Ldhc/Acat2/Acss2/Echdc1/Pcca/Abat 8 rno05150 Staphylococcus aureus infection 12 / 889 57 / 7849 0.02375906 1.62417079 0.254822803 0.233040638 Fcgr2a/Cfh/C1s/C2/C3/Fgg/Icam1/Fcgr2b/Cfb/C1r/C5/LOC498276 12 rno04510 Focal adhesion 33 / 889 206 / 7849 0.02439793 1.61264706 0.254822803 0.233040638 Vegfc/Zyx/Shc3/Egfr/Met/Pdgfrb/Prkcg/Cav1/Lamb2/Kdr/Ppp1cb/Itgb7/Itgb4/Capn2/Mylk3/Flna/Col1a1/Col6a1/Vav3/Lamb3/Dock1/Itgb6/Shc2/Col6a6/Vasp/Col6a2/Col4a3/Cav2/Ccnd2/Birc3/Itga7/Vegfb/Pgf 33 rno00980 Metabolism of xenobiotics by cytochrome P450 14 / 889 71 / 7849 0.02626727 1.58058500 0.26454897 0.241935414 Adh7/Mgst1/Adh1/Gstm1/Gstp1/Hsd11b1/Aldh3a1/Aldh1a3/Gstt2/Gstk1/Aldh3b1/Gsta3/Gstm5/Dhdh 14 rno04976 Bile secretion 14 / 889 72 / 7849 0.02933832 1.53256480 0.285289844 0.260903366 Atp1b2/Abcb1b/Slc2a1/Atp1b1/Hmgcr/Fxyd2/Baat/Slc51a/Slco1b2/Adcy5/Aqp9/Slco1a5/Adcy2/Slc4a4 14 rno05144 Malaria 12 / 889 59 / 7849 0.03051094 1.51554435 0.286770901 0.262257823 Hbb/Met/Vcam1/Icam1/Sdc2/Tgfb3/Il18/Lrp1/Tlr2/Gypc/RGD1565355/Tgfb2 12 rno04964 Proximal tubule bicarbonate reclamation 6 / 889 22 / 7849 0.03152446 1.50135233 0.286770901 0.262257823 Atp1b2/Gls/Glud1/Atp1b1/Fxyd2/Slc4a4 6 rno01040 Biosynthesis of unsaturated fatty acids 7 / 889 29 / 7849 0.03920574 1.40665037 0.325299157 0.297492697 Pecr/Scd1/Baat/Hacd4/Acot1/Acot4/Scd2 7 rno05216 Thyroid cancer 7 / 889 29 / 7849 0.03920574 1.40665037 0.325299157 0.297492697 Tpm3/Lef1/Kras/Ret/Tcf7l1/Tfg/Cdh1 7 rno00520 Amino sugar and nucleotide sugar metabolism 10 / 889 48 / 7849 0.03970151 1.40119294 0.325299157 0.297492697 Gale/Uxs1/Hk1/Gmds/Hexb/Gfpt2/Cmah/Pgm3/Gnpda1/Renbp 10 rno04210 Apoptosis 15 / 889 82 / 7849 0.04037401 1.39389813 0.325299157 0.297492697 Casp12/Il1a/Prkar2b/Cycs/Faslg/Casp3/Tnfrsf1a/Capn2/Birc7/Irak3/Tnfrsf10b/Birc3/Aifm1/Casp6/Dffb 15 rno00910 Nitrogen metabolism 5 / 889 18 / 7849 0.04497819 1.34699799 0.352329187 0.322212209 Glud1/Glul/Car6/Cps1/Car13 5 rno04977 Vitamin digestion and absorption 6 / 889 24 / 7849 0.04682990 1.32947680 0.356919751 0.326410373 Abcc1/Lmbrd1/Slc46a1/Slc52a3/Lrat/Tcn2 6 rno04142 Lysosome 21 / 889 129 / 7849 0.05470367 1.26198355 0.384776583 0.351886012 Scarb2/Acp2/Neu1/Ctsc/Psapl1/Aga/Ctsk/Hexb/Atp6v0a4/Atp6v0d2/Ap3s1/Manba/Glb1/Ap1s1/Sumf1/Gla/Ap1m2/Lgmn/Atp6ap1/Cd164/Asah1 21 rno05202 Transcriptional misregulation in cancer 27 / 889 174 / 7849 0.05471071 1.26192761 0.384776583 0.351886012 Pax3/Cdkn1a/Flt3/Gzmb/Cebpb/Met/Wt1/Arnt2/Plat/Itgb7/Il2rb/Gria3/Mycn/Etv5/Bcl6/Slc45a3/Spint1/Cdk14/Tspan7/Runx2/Prom1/Ccnd2/LOC684841/Meis1/Birc3/Tgfbr2/Hmga2 27 rno00511 Other glycan degradation 5 / 889 19 / 7849 0.05555077 1.25530988 0.384776583 0.351886012 Neu1/Aga/Hexb/Manba/Glb1 5 rno00340 Histidine metabolism 6 / 889 25 / 7849 0.05594269 1.25225662 0.384776583 0.351886012 Aldh3a1/Aldh1a3/Cndp2/Maoa/Hal/Aldh3b1 6 rno05230 Central carbon metabolism in cancer 12 / 889 65 / 7849 0.05883773 1.23034410 0.395053319 0.361284297 Flt3/Egfr/Gls/Kras/Met/Pdgfrb/Ret/Slc2a1/Pgam2/Hk1/Fgfr1/Slc16a3 12 rno00052 Galactose metabolism 7 / 889 32 / 7849 0.06291586 1.20123987 0.412610985 0.37734114 Gale/Hk1/Akr1b8/Galm/Glb1/Gla/Si 7 rno00061 Fatty acid biosynthesis 4 / 889 14 / 7849 0.06481359 1.18833391 0.415396202 0.379888277 Acsl4/Acsl3/Acsbg2/Fasn 4 rno00220 Arginine biosynthesis 5 / 889 20 / 7849 0.06743077 1.17114187 0.422566171 0.38644536 Gls/Glud1/Glul/Arg1/Cps1 5 rno00562 Inositol phosphate metabolism 13 / 889 74 / 7849 0.07057226 1.15136596 0.432638648 0.395656845 Plce1/Inpp4b/Ipmk/Plcd1/Impa2/Mtmr4/Mtm1/Plcg2/Mtmr7/Plch1/Inpp5a/LOC500959/Impa1 13 rno01212 Fatty acid metabolism 10 / 889 54 / 7849 0.07879769 1.10348651 0.462665242 0.423116776 Pecr/Acsl4/Acsl3/Ehhadh/Scd1/Acsbg2/Acat2/Hacd4/Fasn/Scd2 10 rno00603 Glycosphingolipid biosynthesis - globo series 4 / 889 15 / 7849 0.08075915 1.09280824 0.462665242 0.423116776 Hexb/St3gal1/Gla/St3gal2 4 rno00410 beta-Alanine metabolism 7 / 889 34 / 7849 0.08269134 1.08253997 0.462665242 0.423116776 Ehhadh/Aldh3a1/Aldh1a3/Cndp2/Aoc3/Aldh3b1/Abat 7 rno04530 Tight junction 22 / 889 143 / 7849 0.08294848 1.08119157 0.462665242 0.423116776 Magi2/Kras/Myh3/Prkcg/Myh8/Mras/Cldn10/Cldn23/Prkce/Mpdz/Myh13/Cask/Cldn2/Crb3/Cldn15/Cldn4/Cgn/Ctnna3/Ppp2r2b/Sptan1/Myh10/Prkch 22 rno05414 Dilated cardiomyopathy 15 / 889 91 / 7849 0.08621774 1.06440335 0.462665242 0.423116776 Tpm3/Itgb7/Tgfb3/Itgb4/Slc8a1/Cacna2d3/Itgb6/Des/Adcy5/Sgcb/Cacna1s/Ryr2/Itga7/Adcy2/Tgfb2 15 rno04721 Synaptic vesicle cycle 11 / 889 62 / 7849 0.08640119 1.06348026 0.462665242 0.423116776 Cplx2/Ap2b1/Stx1b/Snap25/Stx2/Slc18a2/Atp6v0a4/Atp6v0d2/Atp6v1b1/Rims1/Atp6v0e1 11 rno04512 ECM-receptor interaction 14 / 889 84 / 7849 0.08857939 1.05266730 0.462665242 0.423116776 Sdc4/Gp5/Lamb2/Itgb7/Itgb4/Col1a1/Col6a1/Lamb3/Itgb6/Col6a6/Col6a2/Col4a3/RGD1565355/Itga7 14 rno00650 Butanoate metabolism 6 / 889 28 / 7849 0.08923155 1.04948158 0.462665242 0.423116776 Ehhadh/Hmgcs2/Acsm2a/Acat2/Oxct1/Abat 6 rno05204 Chemical carcinogenesis 15 / 889 92 / 7849 0.09279231 1.03248801 0.462665242 0.423116776 Nat2/Adh7/Mgst1/Adh1/Gstm1/Gstp1/Hsd11b1/Aldh3a1/Aldh1a3/Gstt2/Gstk1/Aldh3b1/Gsta3/Gstm5/Cyp2b15 15 rno05323 Rheumatoid arthritis 15 / 889 92 / 7849 0.09279231 1.03248801 0.462665242 0.423116776 Il1a/Cxcl12/Icam1/Tgfb3/Ctsk/Il18/Atp6v0a4/Atp6v0d2/Mmp1b/Tlr2/Atp6v1b1/Csf1/Tgfb2/Atp6ap1/Atp6v0e1 15 rno05410 Hypertrophic cardiomyopathy (HCM) 14 / 889 85 / 7849 0.09557909 1.01963712 0.462665242 0.423116776 Tpm3/Itgb7/Tgfb3/Itgb4/Slc8a1/Cacna2d3/Itgb6/Des/Prkab2/Sgcb/Cacna1s/Ryr2/Itga7/Tgfb2 14 rno00600 Sphingolipid metabolism 9 / 889 49 / 7849 0.09632104 1.01627885 0.462665242 0.423116776 Asah2/Neu1/Sptlc3/Cerk/Acer2/Glb1/Gla/Sgpp1/Asah1 9 rno04151 PI3K-Akt signaling pathway 46 / 889 336 / 7849 0.09734385 1.01169148 0.462665242 0.423116776 Vegfc/Cdkn1a/Eif4e/Il2rg/Fgf12/Egfr/Epo/Kras/Met/Gng8/Pdgfrb/Il4r/Syk/Ghr/Faslg/Lamb2/Kdr/Gys2/Itgb7/Itgb4/Il2rb/Fgf18/Col1a1/Col6a1/Lamb3/Tlr2/Itgb6/Col6a6/Col6a2/Ppp2r3a/Col4a3/Epha2/Brca1/Lpar2/Kitlg/Gnb3/Ppp2r2b/Ccnd2/Bcl2l11/Csf1/Fgfr1/Nr4a1/Itga7/Gnb5/Vegfb/Pgf 46 rno00533 Glycosaminoglycan biosynthesis - keratan sulfate 4 / 889 16 / 7849 0.09843941 1.00683098 0.462665242 0.423116776 B3gnt2/Chst4/St3gal1/St3gal2 4 rno04911 Insulin secretion 14 / 889 86 / 7849 0.10291132 0.98753685 0.475753967 0.435086682 Rims2/Atp1b2/Prkcg/Slc2a1/Cckar/Snap25/Camk2a/Atp1b1/Fxyd2/Adcy5/Cacna1s/Ryr2/Adcy2/Kcnma1 14 rno03320 PPAR signaling pathway 13 / 889 79 / 7849 0.10610950 0.97424575 0.482627059 0.441372263 Acsl4/Acsl3/Ehhadh/Hmgcs2/Lpl/Scd1/Dbi/Aqp7/Mmp1b/Acsbg2/RGD1565355/Cyp4a1/Scd2 13 rno05205 Proteoglycans in cancer 29 / 889 203 / 7849 0.11046803 0.95676338 0.494475957 0.452208322 Plce1/Cdkn1a/Wnt2b/Wnt11/Egfr/Kras/Met/Prkcg/Sdc4/Esr1/Gpc3/Faslg/Camk2a/Casp3/Cav1/Mras/Kdr/Ppp1cb/Sdc2/Fzd6/Cblc/Plcg2/Flna/Tlr2/Rdx/Cav2/Fgfr1/Mmp2/Tgfb2 29 rno00330 Arginine and proline metabolism 9 / 889 51 / 7849 0.11686113 0.93232992 0.514919348 0.470904219 Cndp2/Arg1/Maoa/Hoga1/Ckmt1b/Agmat/P4ha2/Azin2/Oat 9 rno00072 Synthesis and degradation of ketone bodies 3 / 889 11 / 7849 0.11969472 0.92192499 0.519290954 0.474902142 Hmgcs2/Acat2/Oxct1 3 rno00480 Glutathione metabolism 10 / 889 59 / 7849 0.12496067 0.90322667 0.53392285 0.488283308 Ggt1/Mgst1/Gstm1/Gstp1/Gclc/Gpx8/Gstt2/Gstk1/Gsta3/Gstm5 10 rno04015 Rap1 signaling pathway 30 / 889 216 / 7849 0.13731633 0.86227781 0.574884754 0.525743803 Magi2/Vegfc/Plce1/Fgf12/Drd2/Egfr/Kras/Met/Pdgfrb/Prkcg/P2ry1/Adora2a/Mras/Kdr/Fgf18/Prkd3/Vasp/Rasgrp2/Epha2/Lpar2/Kitlg/Adcy5/Pfn3/Csf1/Fgfr1/Pfn2/Adcy2/Cdh1/Vegfb/Pgf 30 rno00232 Caffeine metabolism 2 / 889 6 / 7849 0.14121825 0.85010919 0.574884754 0.525743803 Nat2/Xdh 2 rno00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5 / 889 25 / 7849 0.14538264 0.83748744 0.574884754 0.525743803 B3galt6/Extl1/Hs6st1/Glce/Hs3st1 5 rno04320 Dorso-ventral axis formation 5 / 889 25 / 7849 0.14538264 0.83748744 0.574884754 0.525743803 Egfr/Kras/Piwil2/Cpeb3/Piwil1 5 rno04970 Salivary secretion 12 / 889 76 / 7849 0.14668596 0.83361145 0.574884754 0.525743803 Adra1b/Atp1b2/Prkcg/Atp1b1/Lpo/Atp2b3/Fxyd2/Gucy1a3/Adcy5/Bst1/Adcy2/Kcnma1 12 rno00130 Ubiquinone and other terpenoid-quinone biosynthesis 3 / 889 12 / 7849 0.14677909 0.83333582 0.574884754 0.525743803 Coq7/Hpd/Vkorc1l1 3 rno00071 Fatty acid degradation 8 / 889 47 / 7849 0.15642064 0.80570593 0.594463393 0.543648867 Acsl4/Acsl3/Ehhadh/Adh7/Adh1/Acsbg2/Acat2/Cyp4a1 8 rno00620 Pyruvate metabolism 7 / 889 40 / 7849 0.16050147 0.79452098 0.594463393 0.543648867 Acot12/Pklr/Pc/Ldhc/Ldhd/Acat2/Acss2 7 rno05143 African trypanosomiasis 7 / 889 40 / 7849 0.16050147 0.79452098 0.594463393 0.543648867 Hbb/Prkcg/Vcam1/Faslg/Icam1/Il18/Ido1 7 rno04390 Hippo signaling pathway 22 / 889 156 / 7849 0.16345863 0.78659216 0.594463393 0.543648867 Wnt2b/Wnt11/Bmpr2/Lef1/Apc/Bmp4/Ppp1cb/Tgfb3/Fzd6/Gli2/Tp53bp2/Lats2/Tcf7l1/Bbc3/Mob1b/Ctnna3/Crb2/Ppp2r2b/Ccnd2/Tgfb2/Tgfbr2/Cdh1 22 rno00280 "Valine, leucine and isoleucine degradation" 9 / 889 55 / 7849 0.16442604 0.78402939 0.594463393 0.543648867 Ehhadh/Hmgcs2/Mcee/Acat2/Mccc2/Aox1/Pcca/Oxct1/Abat 9 rno05217 Basal cell carcinoma 9 / 889 55 / 7849 0.16442604 0.78402939 0.594463393 0.543648867 Wnt2b/Wnt11/Gli1/Lef1/Apc/Bmp4/Fzd6/Gli2/Tcf7l1 9 rno04640 Hematopoietic cell lineage 13 / 889 86 / 7849 0.17083181 0.76743126 0.59889234 0.547699228 Flt3/Epo/Il1a/Il4r/Cd1d1/Gp5/Cd59/Cd7/RGD1565355/Kitlg/Cd55/Tfrc/Csf1 13 rno00920 Sulfur metabolism 3 / 889 13 / 7849 0.17560594 0.75546079 0.59889234 0.547699228 Cycs/Bpnt1/Suox 3 rno04623 Cytosolic DNA-sensing pathway 9 / 889 56 / 7849 0.17757240 0.75062455 0.59889234 0.547699228 Cxcl10/Il18/Ddx58/Polr3h/Polr3a/Il33/Ikbke/Polr3k/Polr3g 9 rno05020 Prion diseases 6 / 889 34 / 7849 0.18077522 0.74286109 0.59889234 0.547699228 C7/Casp12/Il1a/Hspa5/Ncam2/C5 6 rno00460 Cyanoamino acid metabolism 2 / 889 7 / 7849 0.18342190 0.73654882 0.59889234 0.547699228 Ggt1/Shmt1 2 rno00564 Glycerophospholipid metabolism 14 / 889 95 / 7849 0.18345827 0.73646270 0.59889234 0.547699228 Lcat/Pla2g4a/Pemt/Lypla1/Phospho1/Gpat4/Pla2g2c/Gpat2/Pla2g2a/Agpat5/Lpin1/Lpcat3/Agpat1/Gpd1 14 rno04064 NF-kappa B signaling pathway 14 / 889 95 / 7849 0.18345827 0.73646270 0.59889234 0.547699228 Cxcl12/Syk/Vcam1/Icam1/Tnfrsf1a/Erc1/Plcg2/Ddx58/Ccl21/Traf6/Ccl19/Ly96/Blnk/Birc3 14 rno00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 5 / 889 27 / 7849 0.18407281 0.73501035 0.59889234 0.547699228 Pigz/Pigb/Pigh/Pigc/Pigw 5 rno04961 Endocrine and other factor-regulated calcium reabsorption 8 / 889 49 / 7849 0.18476466 0.73338110 0.59889234 0.547699228 Ap2b1/Atp1b2/Prkcg/Klk1c2/Esr1/Atp1b1/Fxyd2/Slc8a1 8 rno04070 Phosphatidylinositol signaling system 14 / 889 96 / 7849 0.19392516 0.71236585 0.610866073 0.558649451 Plce1/Inpp4b/Ipmk/Plcd1/Prkcg/Impa2/Mtmr4/Mtm1/Plcg2/Mtmr7/Ppip5k1/Tmem55a/Inpp5a/Impa1 14 rno05214 Glioma 10 / 889 65 / 7849 0.19586585 0.70804127 0.610866073 0.558649451 Cdkn1a/Shc3/Egfr/Kras/Pdgfrb/Prkcg/Tgfa/Camk2a/Plcg2/Shc2 10 rno04670 Leukocyte transendothelial migration 17 / 889 120 / 7849 0.19613146 0.70745273 0.610866073 0.558649451 Prkcg/Cxcl12/Vcam1/Icam1/Cldn10/Cldn23/Plcg2/Vav3/Cldn2/Cldn15/Cldn4/Txk/Vasp/Ctnna3/Cd99/Cyba/Mmp2 17 rno00250 "Alanine, aspartate and glutamate metabolism" 6 / 889 35 / 7849 0.19877555 0.70163703 0.610866073 0.558649451 Gls/Glud1/Glul/Gfpt2/Cps1/Abat 6 rno05133 Pertussis 11 / 889 73 / 7849 0.19928964 0.70051528 0.610866073 0.558649451 C1s/C2/C3/Il1a/Casp3/Serping1/Traf6/C1r/C5/Ly96/Nod1 11 rno04260 Cardiac muscle contraction 12 / 889 81 / 7849 0.20176147 0.69516176 0.611792856 0.559497013 Tpm3/Atp1b2/Cox6a2/Atp1b1/Fxyd2/Slc8a1/Slc9a6/Cacna2d3/Cox8c/Cox6b2/Cacna1s/Ryr2 12 rno04520 Adherens junction 11 / 889 74 / 7849 0.21188099 0.67390801 0.62686452 0.573280356 Lef1/Acp1/Egfr/Met/Pvrl2/Tcf7l1/Lmo7/Ctnna3/Fgfr1/Tgfbr2/Cdh1 11 rno04971 Gastric acid secretion 11 / 889 74 / 7849 0.21188099 0.67390801 0.62686452 0.573280356 Kcnk2/Atp1b2/Prkcg/Sst/Camk2a/Hrh2/Atp1b1/Cckbr/Mylk3/Adcy5/Adcy2 11 rno04727 GABAergic synapse 13 / 889 90 / 7849 0.21497405 0.66761395 0.62686452 0.573280356 Gabrg1/Gabrr3/Gls/Gng8/Prkcg/Glul/Gnb3/Adcy5/Cacna1s/Gabarapl1/Abat/Adcy2/Gnb5 13 rno04020 Calcium signaling pathway 25 / 889 187 / 7849 0.21562361 0.66630368 0.62686452 0.573280356 Plce1/Adra1b/Agtr1a/Egfr/Gnal/Pdgfrb/Plcd1/Prkcg/Tacr3/Cckar/Ptger3/Tacr2/Avpr1a/Adora2a/Camk2a/Hrh2/Cckbr/Mylk3/Plcg2/Atp2b3/Pde1b/Slc8a1/Cacna1s/Ryr2/Adcy2 25 rno00030 Pentose phosphate pathway 5 / 889 29 / 7849 0.22602563 0.64584231 0.650400288 0.594804295 Aldoc/Prps2/Rgn/Prps1/Rpe 5 rno00561 Glycerolipid metabolism 9 / 889 60 / 7849 0.23448777 0.62987981 0.667934857 0.610840015 Lpl/Akr1b8/Gpat4/Gpat2/Agpat5/Lpin1/Gla/Agpat1/Agk 9 rno04925 Aldosterone synthesis and secretion 12 / 889 84 / 7849 0.23862602 0.62228220 0.672925373 0.615403943 Agtr1a/Npr1/Prkcg/Lipe/Camk2a/Prkce/Cyp11a1/Prkd3/Adcy5/Cacna1s/Nr4a1/Adcy2 12 rno00760 Nicotinate and nicotinamide metabolism 5 / 889 30 / 7849 0.24797672 0.60558909 0.687171372 0.628432199 Nt5c3a/Aox1/Enpp3/Nt5e/Bst1 5 rno04650 Natural killer cell mediated cytotoxicity 14 / 889 101 / 7849 0.25012876 0.60183637 0.687171372 0.628432199 Shc3/Fcgr2a/Gzmb/Kras/Prkcg/Syk/Faslg/Casp3/Icam1/Plcg2/Vav3/Shc2/Tnfrsf10b/Prf1 14 rno04918 Thyroid hormone synthesis 10 / 889 69 / 7849 0.25098813 0.60034683 0.687171372 0.628432199 Atp1b2/Prkcg/Hspa5/Atp1b1/Gpx8/Fxyd2/Iyd/Tpo/Adcy5/Adcy2 10 rno00900 Terpenoid backbone biosynthesis 4 / 889 23 / 7849 0.25929646 0.58620341 0.698052783 0.638383471 Hmgcs2/Hmgcr/Acat2/Fdps 4 rno05152 Tuberculosis 24 / 889 184 / 7849 0.25991327 0.58517155 0.698052783 0.638383471 Fcgr2a/C3/Cebpb/Il1a/Syk/Cycs/Camk2a/Casp3/Tnfrsf1a/Tgfb3/Fcgr2b/Il18/Pla2r1/Atp6v0a4/Atp6v0d2/RGD1564571/Tlr2/Traf6/LOC498276/Cd209e/Clec7a/Hspd1/Tgfb2/Atp6ap1 24 rno04611 Platelet activation 17 / 889 127 / 7849 0.26769530 0.57235926 0.709173427 0.648553526 Fgb/Fgg/Pla2g4a/Syk/Gp5/P2ry1/Ppp1cb/Mylk3/Plcg2/Col1a1/Vasp/Rasgrp2/Gucy1a3/LOC498276/Adcy5/P2ry12/Adcy2 17 rno00120 Primary bile acid biosynthesis 3 / 889 16 / 7849 0.26908353 0.57011288 0.709173427 0.648553526 Cyp7b1/Baat/Hsd17b4 3 rno04310 Wnt signaling pathway 19 / 889 144 / 7849 0.27326183 0.56342103 0.713517003 0.652525814 Wif1/Wnt2b/Wnt11/Lef1/Apc/Prkcg/Mmp7/Camk2a/Fzd6/Cacybp/Nfatc4/Peg12/Tcf7l1/Invs/Prickle1/Gpc4/Cer1/Ccnd2/Bambi 19 rno04380 Osteoclast differentiation 17 / 889 129 / 7849 0.28973379 0.53800086 0.740146199 0.676878756 Fcgr2a/Il1a/Syk/Tnfrsf11b/Fosl2/Tnfrsf1a/Fcgr2b/Ctsk/Plcg2/Traf6/LOC498276/Blnk/Csf1/Cyba/Tgfb2/Tgfbr2/Tec 17 rno03008 Ribosome biogenesis in eukaryotes 12 / 889 88 / 7849 0.29133414 0.53560862 0.740146199 0.676878756 Rpp38/Rexo1l1-ps1/Utp18/Exnef/Utp15/RGD1306195/Rpp25/Utp14a/Utp6/Spata5/Wdr43/Rpp30 12 rno04540 Gap junction 12 / 889 88 / 7849 0.29133414 0.53560862 0.740146199 0.676878756 Drd2/Egfr/Gja1/Kras/Pdgfrb/Prkcg/Tubb6/Gucy1a3/Tubb2a/Tuba1a/Adcy5/Adcy2 12 rno05219 Bladder cancer 6 / 889 40 / 7849 0.29681078 0.52752032 0.741063391 0.677717547 Cdkn1a/Egfr/Kras/Mmp1b/Mmp2/Cdh1 6 rno05210 Colorectal cancer 9 / 889 64 / 7849 0.29695093 0.52731531 0.741063391 0.677717547 Lef1/Apc/Kras/Cycs/Casp3/Tgfb3/Tcf7l1/Tgfb2/Tgfbr2 9 rno04514 Cell adhesion molecules (CAMs) 22 / 889 172 / 7849 0.30373033 0.51751184 0.751332924 0.687109244 Nrxn2/Cdh3/Cntn1/RT1-N1/Sdc4/Spn/Vcam1/Icam1/Sdc2/Itgb7/Ncam2/Cldn10/Cldn23/Sell/Vtcn1/Cldn2/Cldn15/Cldn4/Pvrl2/Cd276/Cd99/Cdh1 22 rno00590 Arachidonic acid metabolism 11 / 889 81 / 7849 0.30792485 0.51155526 0.755085292 0.690540861 Ltc4s/Ggt1/Pla2g4a/Ptgds/Ptgis/Pla2g2c/Gpx8/Pla2g2a/Cyp4a1/Cyp2b15/Alox15 11 rno00750 Vitamin B6 metabolism 2 / 889 10 / 7849 0.31551158 0.50098469 0.767019542 0.701454975 Psat1/Aox1 2 rno05146 Amoebiasis 14 / 889 107 / 7849 0.32438607 0.48893780 0.781853614 0.715021036 Hspb1/Gnal/Prkcg/Cd1d1/Casp3/Lamb2/Tgfb3/Serpinb1a/Arg1/Col1a1/Lamb3/Tlr2/Col4a3/Tgfb2 14 rno05134 Legionellosis 8 / 889 58 / 7849 0.33297004 0.47759485 0.795741949 0.7277222 C3/Cycs/Casp3/Sar1b/Il18/Hspa1b/Tlr2/Hspd1 8 rno04921 Oxytocin signaling pathway 20 / 889 160 / 7849 0.35401084 0.45098344 0.838916438 0.767206149 Cdkn1a/Npr2/Egfr/Kras/Npr1/Pla2g4a/Prkcg/Camk2a/Eef2k/Ppp1cb/Mylk3/Nfatc4/Cacna2d3/Gucy1a3/Camkk1/Adcy5/Prkab2/Cacna1s/Ryr2/Adcy2 20 rno00430 Taurine and hypotaurine metabolism 2 / 889 11 / 7849 0.35902644 0.44487356 0.840573248 0.768721336 Ggt1/Baat 2 rno04950 Maturity onset diabetes of the young 4 / 889 27 / 7849 0.36630037 0.43616264 0.840573248 0.768721336 Pklr/Hes1/Hnf4g/Nkx6-1 4 rno04966 Collecting duct acid secretion 4 / 889 27 / 7849 0.36630037 0.43616264 0.840573248 0.768721336 Atp6v0a4/Atp6v0d2/Atp6v1b1/Atp6v0e1 4 rno00770 Pantothenate and CoA biosynthesis 3 / 889 19 / 7849 0.36663301 0.43576843 0.840573248 0.768721336 Vnn1/Pank1/Enpp3 3 rno05012 Parkinson's disease 19 / 889 153 / 7849 0.37052269 0.43118519 0.842640315 0.77061171 Atp5g3/Drd2/Gnal/Cox6a2/Cycs/Adora2a/Casp3/Slc18a2/Sdhc/Ndufc2/Ndufb6/Ndufa7/Lrrk2/Sncaip/Cox8c/Ndufa9/Adcy5/Cox6b2/Ndufa4 19 rno05213 Endometrial cancer 7 / 889 52 / 7849 0.37456025 0.42647832 0.845007913 0.772776927 Lef1/Apc/Egfr/Kras/Tcf7l1/Ctnna3/Cdh1 7 rno04022 cGMP-PKG signaling pathway 21 / 889 171 / 7849 0.38062566 0.41950194 0.848471505 0.775944452 Npr2/Adra1b/Agtr1a/Atp1b2/Npr1/Kcnj8/Ppp1cb/Atp1b1/Mylk3/Prkce/Atp2b3/Fxyd2/Slc8a1/Nfatc4/Mrvi1/Vasp/Gucy1a3/Adcy5/Cacna1s/Adcy2/Kcnma1 21 rno04350 TGF-beta signaling pathway 11 / 889 86 / 7849 0.38211305 0.41780813 0.848471505 0.775944452 Bmpr2/Fst/Inhbb/Bmp4/Tgfb3/Zfyve16/Nbl1/Ltbp1/Tgfb2/Tgfbr2/Bambi 11 rno04014 Ras signaling pathway 28 / 889 232 / 7849 0.38939154 0.40961349 0.850964206 0.778224078 Vegfc/Plce1/Shc3/Fgf12/Egfr/Kras/Met/Gng8/Pdgfrb/Pla2g4a/Prkcg/Faslg/Mras/Kdr/Plcg2/Fgf18/Pla2g2c/Pla2g2a/Shc2/Rasgrp2/Epha2/Kitlg/Gnb3/Csf1/Fgfr1/Gnb5/Vegfb/Pgf 28 rno04145 Phagosome 24 / 889 198 / 7849 0.39359224 0.40495347 0.850964206 0.778224078 Fcgr2a/C3/RT1-N1/Fcgr2b/Pla2r1/Dync1i1/Atp6v0a4/Atp6v0d2/RGD1564571/Tubb6/Tlr2/Atp6v1b1/C1r/Colec12/LOC498276/Tubb2a/RGD1565355/Cd209e/Clec7a/Tuba1a/Tfrc/Cyba/Atp6ap1/Atp6v0e1 24 rno04010 MAPK signaling pathway 31 / 889 259 / 7849 0.39940298 0.39858870 0.850964206 0.778224078 Dusp1/Map3k1/Fgf12/Cdc25b/Egfr/Hspb1/Il1a/Kras/Pdgfrb/Pla2g4a/Prkcg/Faslg/Casp3/Mras/Tnfrsf1a/Tgfb3/Taok1/Fgf18/Flna/Hspa1b/Ptpn5/Cacna2d3/Traf6/Map3k6/Rasgrp2/Cacna1s/Fgfr1/Nr4a1/Ntf3/Tgfb2/Tgfbr2 31 rno05010 Alzheimer's disease 22 / 889 182 / 7849 0.40615322 0.39131010 0.850964206 0.778224078 Atp5g3/Casp12/Lpl/Cox6a2/Cycs/Casp3/Tnfrsf1a/Apoe/Bace2/Sdhc/Capn2/Ndufc2/Adam10/Ndufb6/Ndufa7/Lrp1/Cox8c/Ndufa9/App/Cox6b2/Ndufa4/Cacna1s 22 rno05161 Hepatitis B 17 / 889 139 / 7849 0.40656431 0.39087075 0.850964206 0.778224078 Egr2/Cdkn1a/Map3k1/Casp12/Kras/Prkcg/Cycs/Faslg/Casp3/Tgfb3/Ddx58/Nfatc4/Tlr2/Ikbke/Tlr3/Tgfb2/Atp6ap1 17 rno00051 Fructose and mannose metabolism 5 / 889 37 / 7849 0.41048036 0.38670761 0.850964206 0.778224078 Aldoc/Hk1/Akr1b8/Gmds/LOC500959 5 rno04072 Phospholipase D signaling pathway 18 / 889 148 / 7849 0.41128724 0.38585477 0.850964206 0.778224078 Shc3/Agtr1a/Egfr/Kras/Pdgfrb/Pla2g4a/Avpr1a/Avpr2/Syk/Mras/Plcg2/Agpat5/Shc2/Agpat1/Lpar2/Kitlg/Adcy5/Adcy2 18 rno04261 Adrenergic signaling in cardiomyocytes 18 / 889 148 / 7849 0.41128724 0.38585477 0.850964206 0.778224078 Tpm3/Adra1b/Agtr1a/Atp1b2/Camk2a/Ppp1cb/Atp1b1/Atp2b3/Fxyd2/Slc8a1/Cacna2d3/Ppp2r3a/Ppp1r1a/Ppp2r2b/Adcy5/Cacna1s/Ryr2/Adcy2 18 rno04115 p53 signaling pathway 9 / 889 71 / 7849 0.41341169 0.38361725 0.850964206 0.778224078 Cdkn1a/Cycs/Casp3/Ppm1d/Sesn1/Gtse1/Gorab/Bbc3/Ccnd2 9 rno05218 Melanoma 9 / 889 71 / 7849 0.41341169 0.38361725 0.850964206 0.778224078 Cdkn1a/Fgf12/Egfr/Kras/Met/Pdgfrb/Fgf18/Fgfr1/Cdh1 9 rno00380 Tryptophan metabolism 6 / 889 46 / 7849 0.42297374 0.37368659 0.864337646 0.790454361 Ehhadh/Maoa/Acat2/Aox1/Tdo2/Ido1 6 rno04724 Glutamatergic synapse 14 / 889 115 / 7849 0.42969065 0.36684410 0.871746501 0.79722991 Grin3a/Gls/Gng8/Pla2g4a/Prkcg/Glul/Slc1a3/Gria3/Slc1a7/Shank3/Gnb3/Adcy5/Adcy2/Gnb5 14 rno05100 Bacterial invasion of epithelial cells 10 / 889 81 / 7849 0.43685053 0.35966713 0.879941781 0.80472466 Shc3/Met/Cav1/Cblc/Dock1/Arhgef26/Shc2/Ctnna3/Cav2/Cdh1 10 rno04141 Protein processing in endoplasmic reticulum 20 / 889 168 / 7849 0.44191515 0.35466111 0.881711453 0.80634306 Lman1/Casp12/Rpn1/Hspa5/Pdia6/Sar1b/Erlec1/Capn2/Hspa1b/Man1a1/Dnajc10/Sec13/Bag1/Tram1/Ubqln2/Dnajb11/Ssr1/Ube2d1/Sec23b/Dnajc5 20 rno04340 Hedgehog signaling pathway 6 / 889 47 / 7849 0.44398236 0.35263428 0.881711453 0.80634306 Wnt2b/Wnt11/Gli1/Bmp4/Gli2/Zic2 6 rno04726 Serotonergic synapse 15 / 889 125 / 7849 0.44723709 0.34946219 0.881964053 0.806574068 Dusp1/Kras/Gng8/Pla2g4a/Prkcg/Casp3/Slc18a2/Slc6a4/Maoa/App/Gnb3/Adcy5/Cacna1s/Alox15/Gnb5 15 rno04012 ErbB signaling pathway 11 / 889 91 / 7849 0.45766936 0.33944817 0.885356625 0.809676644 Cdkn1a/Shc3/Egfr/Kras/Prkcg/Tgfa/Camk2a/Cblc/Plcg2/Shc2/Nrg4 11 rno04666 Fc gamma R-mediated phagocytosis 11 / 889 91 / 7849 0.45766936 0.33944817 0.885356625 0.809676644 Fcgr2a/Pla2g4a/Prkcg/Syk/Fcgr2b/Plcg2/Prkce/Vav3/Vasp/LOC498276/Amph 11 rno05031 Amphetamine addiction 8 / 889 65 / 7849 0.45837612 0.33877801 0.885356625 0.809676644 Grin3a/Prkcg/Camk2a/Slc18a2/Ppp1cb/Maoa/Gria3/Adcy5 8 rno04024 cAMP signaling pathway 23 / 889 196 / 7849 0.46156552 0.33576664 0.885452221 0.809764069 Plce1/Gli1/Grin3a/Atp1b2/Drd2/Npr1/Npy/Pde4b/Ptger3/Lipe/Adora2a/Camk2a/Ppp1cb/Atp1b1/Vav3/Atp2b3/Gria3/Fxyd2/Fxyd1/Adcy5/Cacna1s/Ryr2/Adcy2 23 rno04066 HIF-1 signaling pathway 13 / 889 109 / 7849 0.46599959 0.33161446 0.886785643 0.81098351 Cdkn1a/Timp1/Eif4e/Egfr/Epo/Prkcg/Slc2a1/Tf/Hk1/Camk2a/Plcg2/Tfrc/Tceb2 13 rno00830 Retinol metabolism 10 / 889 83 / 7849 0.46854986 0.32924419 0.886785643 0.81098351 Aldh1a2/Adh7/Adh1/Aldh1a1/Aldh1a7/Rdh11/Cyp4a1/Aox1/Lrat/Cyp2b15 10 rno04975 Fat digestion and absorption 5 / 889 40 / 7849 0.47988996 0.31885833 0.891433864 0.815234403 Pla2g2c/Pla2g2a/Acat2/Agpat1/RGD1565355 5 rno04920 Adipocytokine signaling pathway 9 / 889 75 / 7849 0.48048917 0.31831639 0.891433864 0.815234403 Acsl4/Acsl3/Npy/Slc2a1/Tnfrsf1a/Acsbg2/RGD1565355/Camkk1/Prkab2 9 rno05140 Leishmaniasis 9 / 889 75 / 7849 0.48048917 0.31831639 0.891433864 0.815234403 Fcgr2a/C3/Il1a/Tgfb3/Tlr2/Traf6/LOC498276/Cyba/Tgfb2 9 rno04924 Renin secretion 8 / 889 67 / 7849 0.49375104 0.30649198 0.895386508 0.818849177 Agtr1a/Npr1/Pde1b/Gucy1a3/Clca4l/Adcy5/Cacna1s/Kcnma1 8 rno03020 RNA polymerase 4 / 889 32 / 7849 0.49812952 0.30265772 0.895386508 0.818849177 Polr3h/Polr3a/Polr3k/Polr3g 4 rno04614 Renin-angiotensin system 4 / 889 32 / 7849 0.49812952 0.30265772 0.895386508 0.818849177 Agtr1a/Klk1c2/Cma1/Atp6ap2 4 rno04144 Endocytosis 33 / 889 288 / 7849 0.49997824 0.30104890 0.895386508 0.818849177 Ap2b1/Il2rg/Folr1/Ehd4/Egfr/Met/Ret/RT1-N1/Cav1/Kdr/Tgfb3/Il2rb/Cblc/Tsg101/Capza3/Hspa1b/Snx5/Psd3/Traf6/Rbsn/Vps4b/Ehd2/Snx32/Cav2/Snx12/RGD1566265/Zfyve16/Amph/Tfrc/Tgfb2/Tgfbr2/Sh3gl3/Git1 33 rno04960 Aldosterone-regulated sodium reabsorption 5 / 889 41 / 7849 0.50243915 0.29891653 0.895386508 0.818849177 Atp1b2/Kras/Prkcg/Atp1b1/Fxyd2 5 rno04723 Retrograde endocannabinoid signaling 12 / 889 103 / 7849 0.50487642 0.29681491 0.895386508 0.818849177 Gabrg1/Gabrr3/Gng8/Prkcg/Gria3/Abhd6/Gnb3/Adcy5/Cacna1s/Adcy2/Gnb5/Rims1 12 rno04923 Regulation of lipolysis in adipocytes 7 / 889 59 / 7849 0.50871207 0.29352796 0.895386508 0.818849177 Npr1/Npy/Ptger3/Lipe/Aqp7/Adcy5/Adcy2 7 rno04728 Dopaminergic synapse 15 / 889 130 / 7849 0.51096035 0.29161280 0.895386508 0.818849177 Comt/Drd2/Gng8/Gnal/Prkcg/Camk2a/Slc18a2/Ppp1cb/Maoa/Gria3/Ppp2r3a/Gnb3/Ppp2r2b/Adcy5/Gnb5 15 rno05211 Renal cell carcinoma 8 / 889 68 / 7849 0.51119584 0.29141269 0.895386508 0.818849177 Kras/Met/Slc2a1/Tgfa/Arnt2/Tgfb3/Tceb2/Tgfb2 8 rno04130 SNARE interactions in vesicular transport 4 / 889 33 / 7849 0.52318112 0.28134793 0.906550188 0.82905859 Stx1b/Stx2/Stx19/Vamp5 4 rno04910 Insulin signaling pathway 16 / 889 140 / 7849 0.52488404 0.27993663 0.906550188 0.82905859 Sh2b2/Shc3/Eif4e/Kras/Pklr/Prkar2b/Hk1/Lipe/Ppp1cb/Gys2/Cblc/Ppp1r3c/Shc2/Fasn/Prkab2/Ppp1r3d 16 rno04370 VEGF signaling pathway 7 / 889 60 / 7849 0.52721358 0.27801341 0.906550188 0.82905859 Hspb1/Kras/Pla2g4a/Prkcg/Kdr/Plcg2/Shc2 7 rno00310 Lysine degradation 6 / 889 52 / 7849 0.54567997 0.26306198 0.93095144 0.851374031 Ehhadh/Aass/Camkmt/Plod2/Acat2/Suv420h1 6 rno00592 alpha-Linolenic acid metabolism 3 / 889 25 / 7849 0.55016864 0.25950417 0.93095144 0.851374031 Pla2g4a/Pla2g2c/Pla2g2a 3 rno04062 Chemokine signaling pathway 20 / 889 178 / 7849 0.55130812 0.25860561 0.93095144 0.851374031 Shc3/Xcl1/Kras/Cxcl10/Gng8/Cxcl12/Ccl7/Vav3/Ccl21/Shc2/Rasgrp2/Ccl27/Ccl19/Cxcl16/Cxcl13/Gnb3/Adcy5/Ccl26/Adcy2/Gnb5 20 rno05034 Alcoholism 20 / 889 179 / 7849 0.56193687 0.25031247 0.943251173 0.862622386 Shc3/Grin3a/Drd2/Kras/Gng8/Npy/Adora2a/Slc18a2/Ppp1cb/Maoa/Hist1h2bh/Shc2/RGD1562378/Camkk1/Gnb3/Slc29a1/Adcy5/LOC684841/Gnb5/Hdac7 20 rno04973 Carbohydrate digestion and absorption 5 / 889 44 / 7849 0.56754752 0.24599777 0.94696839 0.866021857 Atp1b2/Hk1/Atp1b1/Fxyd2/Si 5 rno00190 Oxidative phosphorylation 16 / 889 144 / 7849 0.57255099 0.24218583 0.94696839 0.866021857 Atp5g3/Cox6a2/Sdhc/Ndufc2/Atp6v0a4/Atp6v0d2/Ndufb6/Ndufa7/Atp6v1b1/Cox8c/Ndufa9/Cox6b2/Ndufa4/Cox11/Atp6ap1/Atp6v0e1 16 rno04916 Melanogenesis 11 / 889 99 / 7849 0.57475903 0.24051419 0.94696839 0.866021857 Wnt2b/Wnt11/Lef1/Kras/Prkcg/Camk2a/Fzd6/Tcf7l1/Kitlg/Adcy5/Adcy2 11 rno03060 Protein export 3 / 889 26 / 7849 0.57767277 0.23831811 0.94696839 0.866021857 Hspa5/Spcs2/Spcs3 3 rno03018 RNA degradation 9 / 889 82 / 7849 0.59235313 0.22741931 0.94696839 0.866021857 Pabpc6/Btg1/Exosc7/Pan3/Wdr61/Lsm6/Hspd1/Lsm2/LOC688828 9 rno00040 Pentose and glucuronate interconversions 4 / 889 36 / 7849 0.59443422 0.22589620 0.94696839 0.866021857 Akr1b8/Cryl1/Rpe/Dhdh 4 rno04360 Axon guidance 14 / 889 128 / 7849 0.59770728 0.22351145 0.94696839 0.866021857 Kras/Met/Cxcl12/Sema3c/Sema3a/Nfatc4/Sema4d/Sema5a/Sema3f/Epha4/Slit2/Epha2/Unc5b/Slit3 14 rno04919 Thyroid hormone signaling pathway 13 / 889 119 / 7849 0.59900406 0.22257024 0.94696839 0.866021857 Plce1/Atp1b2/Kras/Plcd1/Prkcg/Slc2a1/Esr1/Bmp4/Atp1b1/Plcg2/Fxyd2/Med4/Thra 13 rno05032 Morphine addiction 10 / 889 92 / 7849 0.60466184 0.21848744 0.94696839 0.866021857 Gabrg1/Gabrr3/Gng8/Pde4b/Prkcg/Pde1b/Gnb3/Adcy5/Adcy2/Gnb5 10 rno05162 Measles 15 / 889 138 / 7849 0.60833767 0.21585529 0.94696839 0.866021857 Il2rg/Il1a/Faslg/Il2rb/Fcgr2b/Hspa1b/Ddx58/RGD1564571/Tlr2/Traf6/Bbc3/Ikbke/Tnfrsf10b/Cd209e/Ccnd2 15 rno05030 Cocaine addiction 5 / 889 46 / 7849 0.60841522 0.21579993 0.94696839 0.866021857 Grin3a/Drd2/Slc18a2/Maoa/Adcy5 5 rno05160 Hepatitis C 14 / 889 129 / 7849 0.60980602 0.21480830 0.94696839 0.866021857 Cdkn1a/Egfr/Kras/Tnfrsf1a/Cldn10/Cldn23/Ddx58/Cldn2/Cldn15/Cldn4/Traf6/Ikbke/Tlr3/Ppp2r2b 14 rno04931 Insulin resistance 12 / 889 111 / 7849 0.61353599 0.21215996 0.94696839 0.866021857 Slc2a1/Ppp1cb/Gys2/Tnfrsf1a/Ppargc1b/Prkce/Ppp1r3c/Gfpt2/Ppp2r4/RGD1565355/Prkab2/Ppp1r3d 12 rno05321 Inflammatory bowel disease (IBD) 7 / 889 65 / 7849 0.61510038 0.21105401 0.94696839 0.866021857 Il2rg/Il1a/Il4r/Tgfb3/Il18/Tlr2/Tgfb2 7 rno04810 Regulation of actin cytoskeleton 24 / 889 221 / 7849 0.62014657 0.20750565 0.94696839 0.866021857 Fgf12/Apc/Egfr/Kras/Pdgfrb/Mras/Ppp1cb/Itgb7/Itgb4/Diaph3/Mylk3/Fgf18/Vav3/Cyfip2/Dock1/Itgb6/Nckap1l/Rdx/Pfn3/Fgfr1/Myh10/Itga7/Pfn2/Git1 24 rno05223 Non-small cell lung cancer 6 / 889 56 / 7849 0.62062924 0.20716776 0.94696839 0.866021857 Egfr/Kras/Prkcg/Tgfa/Plcg2/Fhit 6 rno00670 One carbon pool by folate 2 / 889 18 / 7849 0.62123813 0.20674190 0.94696839 0.866021857 Shmt1/Mthfd2 2 rno02010 ABC transporters 5 / 889 47 / 7849 0.62799057 0.20204688 0.952114728 0.870728288 Abcc1/Abcb1b/Abcd4/Abca8a/Abca4 5 rno04913 Ovarian steroidogenesis 6 / 889 57 / 7849 0.63823012 0.19502270 0.962388211 0.880123597 Pla2g4a/Hsd17b7/Cyp11a1/Adcy5/Hsd17b2/Adcy2 6 rno05220 Chronic myeloid leukemia 8 / 889 76 / 7849 0.64159214 0.19274096 0.962388211 0.880123597 Cdkn1a/Shc3/Kras/Tgfb3/Cblc/Shc2/Tgfb2/Tgfbr2 8 rno05145 Toxoplasmosis 13 / 889 123 / 7849 0.64792656 0.18847422 0.9625263 0.880249883 Cycs/Casp3/Lamb2/Tnfrsf1a/Tgfb3/Hspa1b/Birc7/Lamb3/Tlr2/Traf6/Ly96/Birc3/Tgfb2 13 rno00450 Selenocompound metabolism 2 / 889 19 / 7849 0.65119167 0.18629116 0.9625263 0.880249883 Cth/Txnrd2 2 rno00062 Fatty acid elongation 3 / 889 29 / 7849 0.65355991 0.18471460 0.9625263 0.880249883 Hacd4/Acot1/Acot4 3 rno04621 NOD-like receptor signaling pathway 6 / 889 58 / 7849 0.65533706 0.18353527 0.9625263 0.880249883 Il18/Traf6/Nlrp1a/Nod1/Nlrp1b/Birc3 6 rno04750 Inflammatory mediator regulation of TRP channels 12 / 889 115 / 7849 0.66332782 0.17827179 0.969214738 0.886366595 Pla2g4a/Prkcg/Asic2/Camk2a/Ppp1cb/Plcg2/Prkce/Cyp4a1/Asic4/Adcy5/Adcy2/Prkch 12 rno04932 Non-alcoholic fatty liver disease (NAFLD) 17 / 889 162 / 7849 0.66934073 0.17435274 0.971766048 0.88869982 Il1a/Pklr/Cox6a2/Cycs/Faslg/Casp3/Tnfrsf1a/Sdhc/Ndufc2/Ndufb6/Ndufa7/Cox8c/Ndufa9/Bcl2l11/Prkab2/Cox6b2/Ndufa4 17 rno04713 Circadian entrainment 10 / 889 97 / 7849 0.67246142 0.17233263 0.971766048 0.88869982 Gng8/Prkcg/Camk2a/Gria3/Gucy1a3/Gnb3/Adcy5/Ryr2/Adcy2/Gnb5 10 rno00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3 / 889 30 / 7849 0.67657186 0.16968607 0.971766048 0.88869982 B3gnt2/Gcnt2/B3galt2 3 rno05033 Nicotine addiction 4 / 889 40 / 7849 0.67885784 0.16822116 0.971766048 0.88869982 Gabrg1/Grin3a/Gabrr3/Gria3 4 rno05166 HTLV-I infection 31 / 889 293 / 7849 0.68709348 0.16298417 0.978587685 0.894938346 Egr2/Cdkn1a/Wnt2b/Map3k1/Wnt11/Il2rg/Apc/Tspo/Kras/Pdgfrb/RT1-N1/Slc2a1/Vcam1/Atf3/Icam1/Mras/Tnfrsf1a/Tgfb3/Il2rb/Fzd6/Mybl1/Nfatc4/RGD1306195/Ccnd2/Adcy5/Zfp36/Adcy2/Msx1/Tgfb2/Tgfbr2/Fdps 31 rno05215 Prostate cancer 9 / 889 89 / 7849 0.69141294 0.16026250 0.979296566 0.895586632 Cdkn1a/Lef1/Egfr/Gstp1/Kras/Pdgfrb/Tgfa/Tcf7l1/Fgfr1 9 rno00591 Linoleic acid metabolism 4 / 889 41 / 7849 0.69793013 0.15618805 0.979296566 0.895586632 Pla2g4a/Pla2g2c/Pla2g2a/Alox15 4 rno00531 Glycosaminoglycan degradation 2 / 889 21 / 7849 0.70539552 0.15156731 0.979296566 0.895586632 Hexb/Glb1 2 rno00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2 / 889 21 / 7849 0.70539552 0.15156731 0.979296566 0.895586632 B3galt6/Csgalnact1 2 rno00140 Steroid hormone biosynthesis 8 / 889 81 / 7849 0.71214799 0.14742975 0.979296566 0.895586632 Comt/Hsd11b1/Cyp7b1/Hsd17b7/Cyp11a1/ste2/Cyp2b15/Hsd17b2 8 rno04152 AMPK signaling pathway 13 / 889 129 / 7849 0.71493946 0.14573073 0.979296566 0.895586632 Scd1/Lipe/Eef2k/Gys2/Hmgcr/Cab39/Ppp2r3a/RGD1565355/Fasn/Camkk1/Ppp2r2b/Prkab2/Scd2 13 rno04668 TNF signaling pathway 11 / 889 110 / 7849 0.71499104 0.14569940 0.979296566 0.895586632 Magi2/Cebpb/Cxcl10/Vcam1/Casp3/Icam1/Tnfrsf1a/Bag4/Bcl3/Csf1/Birc3 11 rno04912 GnRH signaling pathway 9 / 889 92 / 7849 0.72892826 0.13731521 0.979296566 0.895586632 Map3k1/Egfr/Kras/Pla2g4a/Camk2a/Adcy5/Cacna1s/Adcy2/Mmp2 9 rno00500 Starch and sucrose metabolism 5 / 889 53 / 7849 0.73231580 0.13530160 0.979296566 0.895586632 Uxs1/Hk1/Gys2/Si/Enpp3 5 rno04962 Vasopressin-regulated water reabsorption 4 / 889 43 / 7849 0.73359738 0.13454223 0.979296566 0.895586632 Avpr2/Dctn1/Dync1i1/Arhgdib 4 rno03015 mRNA surveillance pathway 9 / 889 93 / 7849 0.74073207 0.13033885 0.979296566 0.895586632 Ppp1cb/Smg6/Pabpc6/Cpsf2/Rngtt/Upf2/Ppp2r3a/Ppp2r2b/Magohb 9 rno04630 Jak-STAT signaling pathway 15 / 889 151 / 7849 0.74438994 0.12819950 0.979296566 0.895586632 Cdkn1a/Il2rg/Il13ra2/Epo/Gfap/Pim1/Il4r/Fhl1/Ghr/Il13ra1/Il2rb/Socs5/Il20rb/Aox1/Ccnd2 15 rno04080 Neuroactive ligand-receptor interaction 30 / 889 292 / 7849 0.74533404 0.12764904 0.979296566 0.895586632 Gpr50/Gabrg1/P2ry14/Grin3a/Gabrr3/Adra1b/Agtr1a/Tspo/Drd2/Tacr3/Vipr1/Cckar/Ptger3/Tacr2/Chrna3/Avpr1a/Avpr2/Ghr/P2ry1/Ghrhr/Adora2a/Hrh2/Cckbr/Gzma/Taar6/Chrne/Gria3/Lpar2/Grid1/Thra 30 rno00565 Ether lipid metabolism 4 / 889 44 / 7849 0.75020237 0.12482157 0.979296566 0.895586632 Pla2g4a/Pla2g2c/Pla2g2a/Enpp2 4 rno05212 Pancreatic cancer 6 / 889 65 / 7849 0.76044417 0.11893267 0.979296566 0.895586632 Egfr/Kras/Tgfa/Tgfb3/Tgfb2/Tgfbr2 6 rno04071 Sphingolipid signaling pathway 12 / 889 124 / 7849 0.76104304 0.11859078 0.979296566 0.895586632 Asah2/Kras/Abcc1/Prkcg/Tnfrsf1a/Prkce/Sptlc3/Acer2/Ppp2r3a/Ppp2r2b/Sgpp1/Asah1 12 rno04917 Prolactin signaling pathway 7 / 889 76 / 7849 0.77256966 0.11206235 0.979296566 0.895586632 Wap/Shc3/Kras/Esr1/Shc2/Socs5/Ccnd2 7 rno04915 Estrogen signaling pathway 9 / 889 96 / 7849 0.77401565 0.11125026 0.979296566 0.895586632 Shc3/Egfr/Kras/Esr1/Hspa1b/Shc2/Adcy5/Adcy2/Mmp2 9 rno03013 RNA transport 16 / 889 164 / 7849 0.77426043 0.11111294 0.979296566 0.895586632 Eif4e/Eif2b3/Rpp38/Pabpc6/Sec13/Sumo1/Eif1ax/Cyfip2/RGD1306195/Rpp25/Upf2/Rangap1/Paip1/Gemin4/Rpp30/Magohb 16 rno00983 Drug metabolism - other enzymes 5 / 889 56 / 7849 0.77579175 0.11025484 0.979296566 0.895586632 Nat2/Ces2c/Ces1e/Xdh/Tpmt 5 rno05014 Amyotrophic lateral sclerosis (ALS) 5 / 889 56 / 7849 0.77579175 0.11025484 0.979296566 0.895586632 Casp12/Prph/Cycs/Casp3/Tnfrsf1a 5 rno04722 Neurotrophin signaling pathway 12 / 889 126 / 7849 0.77986518 0.10798047 0.979296566 0.895586632 Sh2b2/Shc3/Map3k1/Kras/Faslg/Camk2a/Plcg2/Traf6/Shc2/Irak3/Arhgdib/Ntf3 12 rno04068 FoxO signaling pathway 13 / 889 136 / 7849 0.78229941 0.10662700 0.979296566 0.895586632 Cdkn1a/Egfr/Kras/Faslg/Tgfb3/Bcl6/Klf2/Ccnd2/Bcl2l11/Prkab2/Gabarapl1/Tgfb2/Tgfbr2 13 rno04940 Type I diabetes mellitus 7 / 889 77 / 7849 0.78418121 0.10558357 0.979296566 0.895586632 Gzmb/Il1a/RT1-N1/Faslg/Cpe/Prf1/Hspd1 7 rno05142 Chagas disease (American trypanosomiasis) 10 / 889 107 / 7849 0.78551064 0.10484793 0.979296566 0.895586632 C3/Gnal/Faslg/Tnfrsf1a/Tgfb3/Tlr2/Traf6/Ppp2r2b/Tgfb2/Tgfbr2 10 rno05221 Acute myeloid leukemia 5 / 889 57 / 7849 0.78901883 0.10291263 0.979296566 0.895586632 Flt3/Lef1/Kras/Pim1/Tcf7l1 5 rno00790 Folate biosynthesis 1 / 889 13 / 7849 0.79069387 0.10199163 0.979296566 0.895586632 Alpi 1 rno03450 Non-homologous end-joining 1 / 889 13 / 7849 0.79069387 0.10199163 0.979296566 0.895586632 Xrcc4 1 rno03030 DNA replication 3 / 889 36 / 7849 0.79105937 0.10179092 0.979296566 0.895586632 Rpa3/Mcm2/Rnaseh2a 3 rno05222 Small cell lung cancer 8 / 889 88 / 7849 0.79444334 0.09993707 0.979296566 0.895586632 Cycs/Lamb2/Birc7/Lamb3/Traf6/Col4a3/Fhit/Birc3 8 rno00270 Cysteine and methionine metabolism 4 / 889 47 / 7849 0.79524437 0.09949939 0.979296566 0.895586632 Cth/Gclc/Ldhc/Sdsl 4