CLUSTAL O(1.1.0) multiple sequence alignment Homo_sapiens_CAVI ------------------------------------------------------------ Mus_musculus_CAVI ------------------------------------------------------------ Equus_caballus_CAVI ------------------------------------------------------------ Gallus_gallus_CAVI ------------------------------------------------------------ Meleagris_gallopavo_CAVI ------------------------------------------------------------ Xenopus_tropicalis_CAVI ------------------------------------------------------------ Danio_rerio_CAVI ------------------------------------------------------------ Homo_sapiens_CAIX MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL Mus_musculus_CAIX MASLGPSPWAPLSTPAPTA----QLLLFLLLQVSAQPQGLSGMQGEPSLGDSSSGE-DEL Monodelphis_domestica_CAIX MAPPCPGR-LPLLSPARAP---ICLLLLLLLLAPSHPYSVVGRERDSSE-----EEGD-- Gallus_gallus_CAIX ------------------------------------------------------------ Chrysemys_picta_bellii_CAIX ------------------------------------------------------------ Latimeria_chalumnae_CAIX ------------------------------------------------------------ Danio_rerio_CAIX ------------------------------------------------------------ Homo_sapiens_CAXII ------------------------------------------------------------ Mus_musculus_CAXII ------------------------------------------------------------ Monodelphis_domestica_CAXII ------------------------------------------------------------ Meleagris_gallopavo_CAXII ------------------------------------------------------------ Xenopus_tropicalis_CAXII ------------------------------------------------------------ Latimeria_chalumnae_CAXII ------------------------------------------------------------ Danio_rerio_CAXII ------------------------------------------------------------ Homo_sapiens_CAXIV ------------------------------------------------------------ Mus_musculus_CAXIV ------------------------------------------------------------ Monodelphis_domestica_CAXIV ------------------------------------------------------------ Meleagris_gallopavo_CAXIV ------------------------------------------------------------ Xenopus_tropicalis_CAXIV ------------------------------------------------------------ Latimeria_chalumnae_CAXIV ------------------------------------------------------------ Danio_rerio_CAXIV ------------------------------------------------------------ Drosophila_melanogaster_CAH1 ------------------------------------------------------------ Homo_sapiens_CAVI ------------------------------------------------MRAL---VLL-L Mus_musculus_CAVI ------------------------------------------------MRAL---VSV-V Equus_caballus_CAVI ------------------------------------------------MQAP---LTL-L Gallus_gallus_CAVI ------------------------------------------------MLIP---TAL-L Meleagris_gallopavo_CAVI ------------------------------------------------MLIP---TAL-L Xenopus_tropicalis_CAVI --------------------------------------------MA--RLLQ---LGL-Y Danio_rerio_CAVI -------------------------------------------------MEQ---LTL-V Homo_sapiens_CAIX GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDL------PEVKPKSEEEGS------- Mus_musculus_CAIX GVDVLPSEEDAPEEADPPDGED------------P------PEVNSEDRMEES------- Monodelphis_domestica_CAIX ----PPGAEDGPQEEKPPGEEQLSRERETPGQGDPSREEDPPREEVPHREEDP------- Gallus_gallus_CAIX ------------------------------------------------MNRTA------- Chrysemys_picta_bellii_CAIX ------------------------------------------------MSCTR------- Latimeria_chalumnae_CAIX ------------------------------------------------MG-----NTLLF Danio_rerio_CAIX ------------------------------------------------ML-----LGFLL Homo_sapiens_CAXII ----------------------------------------MPRRSL---HAAA--VLLLV Mus_musculus_CAXII ----------------------------------------MPHRSL---RATV--VLLLV Monodelphis_domestica_CAXII ----------------------------------------MPAQGFGFSAAGA--TVLIL Meleagris_gallopavo_CAXII ----------------------------------------MSVKSCN-RAIVT--PVLIF Xenopus_tropicalis_CAXII -------------------------------------------------QA-M--YVLLL Latimeria_chalumnae_CAXII ----------------------------------------------------C--YILVL Danio_rerio_CAXII -----------------------------------------------LSSEEF--HILLG Homo_sapiens_CAXIV --------------------------------------------------------MLFS Mus_musculus_CAXIV --------------------------------------------------------MLFF Monodelphis_domestica_CAXIV -------------------------------------------------------MLLFL Meleagris_gallopavo_CAXIV --------------------------------------------------------SLFG Xenopus_tropicalis_CAXIV --------------------------------------------------------MLCL Latimeria_chalumnae_CAXIV --------------------------------------------------------MFFL Danio_rerio_CAXIV ----------------------------------------------------M--DHIWT Drosophila_melanogaster_CAH1 ------------------------------------------------------------ ** Homo_sapiens_CAVI -----SLFL-------------------------LGGQAQHVSDWTYSE-GALDEAHWPQ Mus_musculus_CAVI -----SLFF-------------------------LGIQA--HSDWSYSGDDGVGESQWSE Equus_caballus_CAVI -----SLLL-------------------------LGAQA--GQHWTYSD-GELDEAHWSN Gallus_gallus_CAVI ----------LLQ---------------------LLSC-SHAVHWTYRE-GELDEEHWGL Meleagris_gallopavo_CAVI ----------LLQ---------------------LLSC-SHAVHWTYRE-GELDEEHWGL Xenopus_tropicalis_CAVI ------LFLVLAC---------------------HLTT-SHVVEWTYQE-GEVDEANWGK Danio_rerio_CAVI -----LLFVTSLN---------------------FASAGVDGDYWTY-S-GELDQKHWAE Homo_sapiens_CAIX -LKLEDL--PTV---EAP--GDPQ--EPQ-NNAHRDKEGDDQSHWRYGG-----DPPWPR Mus_musculus_CAIX -LGLEDL--STP---EAP--EHS-------QGSHGDEKGGGHSHWSYGG-----TLLWPQ Monodelphis_domestica_CAIX -PREEDP--PIV---QAS--PVSE--DPDSHRNVPEKKDDDHQHWRYGG-----GPLWPR Gallus_gallus_CAIX -LRVCVLLLAGL--GRAAGGQEHD--HNDENAPHSAEKGPSDSHWSYED-----PGQWAK Chrysemys_picta_bellii_CAIX -LGLSLLLLAAL--GW----TEDE--HGSEDSSHPKKKGPGHGHWSYAD-----KDEWPL Latimeria_chalumnae_CAIX ILVVSQVLLPGP--------TVAGKTVTQRQIGEDESGENKKSHEHNKD-----QNQWSM Danio_rerio_CAIX ILHLQLLLVASS--------SSSEEDKSSERDGQHSKGSSHQHHWGYQD-----QDAWLS Homo_sapiens_CAXII IL--------------------------KEQP--SSPAPVNGSKWTYFG--PDGENSWSK Mus_musculus_CAXII IL--------------------------KKQP--SSSAPLNGSKWTYVG--PAGEKNWSK Monodelphis_domestica_CAXII FL--------------------------KVQT--SVPAPLNGSKWTYDG--EDGEKAWSK Meleagris_gallopavo_CAXII YL--------------------------KIQL--SVPASLNGSKWSYIG--PDGENTWPK Xenopus_tropicalis_CAXII VL--------------------------LALP--SCQAASEGHGWAYIG--TKGEKSWPK Latimeria_chalumnae_CAXII YF--------------------------FFLL--VCQRL--TFSCLTTG--PKGMPHWSK Danio_rerio_CAXII YLIVNL--------------------KSVKEP--GSAFSFSGRKWTYNG--LDGEHDWPT Homo_sapiens_CAXIV ALL-----------------------LEVI----WILAADGGQHWTYEG--PHGQDHWPA Mus_musculus_CAXIV ALL-----------------------LKVT----WILAADGGHHWTYEG--PHGQDHWPT Monodelphis_domestica_CAXIV NLL-----------------------LELV----RILAADGGSHWTYEG--PHGQDHWPA Meleagris_gallopavo_CAXIV QRG-----------------------GRRR----WXSASFTGPHWTYEG--PHGQHHWPE Xenopus_tropicalis_CAXIV SLL----------------------ILSI--S--H-VTVRVPDWYGSAG--HHGQENWPV Latimeria_chalumnae_CAXIV VLI----------------------LFLL--P--F-IAVNVCLFYLFPG--PHGQEHWAS Danio_rerio_CAXIV TLAFS---------------------FVLK----CVECSGSATKWTYTG--AVGQPEWIE Drosophila_melanogaster_CAH1 ----------------------------------------MSHHWGYTE--ENGPAHWAK * * Homo_sapiens_CAVI HYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYET-Q-AGEFPMVNNGHT--VQISLPS Mus_musculus_CAVI QYPSCGGERQSPIDVKTEEVMFNPSLKPLSLVNYEK-E-NLEFTMTNNGHT--VSIDLPP Equus_caballus_CAVI EYPTCGGDRQSPIDLQSKKMRYNPSLKPLTLVGYED-Q-EGEFSMTNNGHT--VQISLRP Gallus_gallus_CAVI HFAACAGKQQSPIDIQRRNVVHNAQLLQLELSGYSRPL-QEDCTMTNNGHS--VQIDLPP Meleagris_gallopavo_CAVI HFAACAGKQQSPIDIQRKKVVHNVQLLQLELSGYSRPL-QGDFTMTNNGHS--VQIDLPP Xenopus_tropicalis_CAVI KYPVCALRHQSPIDIQRKKVRHNPELAQLELIGYDGPL-TGHFKVTNNGHS--VQIDLPP Danio_rerio_CAVI KYHDCGGQQQSPIDIQRRKVRYSPRMQQLELTGYED-I-RGSFLMKNNGHS--VEIQLPS Homo_sapiens_CAIX VSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPP-LPELRLRNNGHS--VQLTLPP Mus_musculus_CAIX VSPACAGRFQSPVDIRLERTAFCRTLQPLELLGYELQP-LPELSLSNNGHT--VQLTLPP Monodelphis_domestica_CAIX VSRACGGHLQSPVDIRPDSTYFRPDLVAPQLHGFFLPP-DQPLKLKNNGHT--VQLTLPP Gallus_gallus_CAIX HFPACSGTMQSPININTETTIFSPQLRPIQLSGYSLPA-SQMLALKNNGHT--VVLKLPE Chrysemys_picta_bellii_CAIX EFPDCGGQMQSPINIDTNSTIFSHELQPVVLAGYNLDP-SERLSLMNNGHT--VVLRLPG Latimeria_chalumnae_CAIX DYEDCGKTAQSPIDIMTGLSLST-ALLSIKPEGYDLRDQEKKLTLLNNGHT--VQLNLPD Danio_rerio_CAIX AFEHCGGKSQSPINIDTHKVLHEPRLPPIQLDGYDLTG-SHSLTLLNNGHT--LQLSLPS Homo_sapiens_CAXII KYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSA-NKQFLLTNNGHS--VKLNLPS Mus_musculus_CAXII KYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSV-EKLLNLTNDGHS--VRLNLNS Monodelphis_domestica_CAXII SFPSCGGMFQSPIDFHNDILQYDSTLLPLVFEGYNMSF-KEQFILTNNGHS--VKLNLPP Meleagris_gallopavo_CAXII KYPFCGGVFQSPIDFHKDILQYDSNLSPLEFIGYNVSS-TDQFTLTNNGHS--VKMHLSP Xenopus_tropicalis_CAXII NYEFCGGVYQSPIDIHQDILQYDSSLQPVKLNGYNVSP-AESFTLSNNGHT--VQMSLVP Latimeria_chalumnae_CAXII QYPFCGGSFQSPIDFYRDIIQFTSSLKPIEVMNYNLSS-TVLYTLSNNGHS--VKMSLPS Danio_rerio_CAXII NYPFCGGAFQSPIDFQTHLLRYDPNLPPIQVQNYNLST-SEQLTLGNNGHSATVQLSLPS Homo_sapiens_CAXIV SYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPG-TEPLDLHNNGHT--VQLSLPS Mus_musculus_CAXIV SYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLG-TEPLDLHNNGHT--VQLSLPP Monodelphis_domestica_CAXIV TYPECGSNAQSPIDIQTERVTFDSELPAVQPHGYDQPG-TEPLSLHNNGHT--VQLSLPP Meleagris_gallopavo_CAXIV GHPACGGRSQSPIDIATQRVLPDPSLPPIRPMGYDHPL-VPTFSLTNNGHT--VVLALPP Xenopus_tropicalis_CAXIV TYPDCGGTAQSPINIQTSNISYDESLPPIEPEGYNTPG-NQPFTLTNNGHS--VELSLPS Latimeria_chalumnae_CAXIV VYPNCGGTAQSPINIETRHVKYDSLLRPVEPEKYGNPE-SDPFTLLNNGHT--VEMALPI Danio_rerio_CAXIV FFPECGGFNQSPVNVDTSQTLHDPTLIPVQPMGYNQPG-RRPFILSNNGHT--VQMTLPH Drosophila_melanogaster_CAH1 EYPQASGHRQSPVDITPSSAKKGSELNVAP-LKWKYVP-EHTKSLVNPGYCWRVDVNGAD .. ***::. : : : * *: : : Homo_sapiens_CAVI TM-RMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNS-KYKSYDI Mus_musculus_CAVI SM-YLETSDGTEFISKAFHFHWGGRDWELSGSEHTIDGIRSIMEAHFVHFNK-EYGTYEN Equus_caballus_CAVI TM-HMEAADGTKYVAEQMHFHWGGGASEISGSEHTIDGIRYVTEIHLVHYNS-KYGSYDI Gallus_gallus_CAVI TL-SISRGLPRPYTAVQMHLHWGGLDLETSGSEHTLDGMRYVAELHIVHYNSADYSSFEE Meleagris_gallopavo_CAVI TL-SISRGLPHPYTAVQMHLHWGGLDLETSGSEHTLDGMRYVAELHIVHYNSADYSSFEE Xenopus_tropicalis_CAVI SM-TIKKGLNSLYTAVQMHLHWGGLESETSGSEHTIDGMRYLAELHVVHYNSGTYKTFDE Danio_rerio_CAVI TM-KITKGFPHQYTAVQMHLHWGGWDLEASGSEHTMDGIRYMAELHVVHYNSEKYPSFEE Homo_sapiens_CAIX GL-EMALGPGREYRALQLHLHWGAA--GRPGSEHTVEGHRFPAEIHVVHLST-AFARVDE Mus_musculus_CAIX GL-KMALGPGQEYRALQLHLHWGTS--DHPGSEHTVNGHRFPAEIHVVHLST-AFSELHE Monodelphis_domestica_CAIX GL-WMTMGLGTEYRALQLHLHWGAP--GVPGSEHTVNGHHFPAEIHVVHLNT-RFDTDHE Gallus_gallus_CAIX SL-AITGGYAQQYRAVQLHLHWGSP--SNPGSEHTVDHKRFAGELHVVHYNT-KYENFEA Chrysemys_picta_bellii_CAIX SL-TIASGYPQEYRAMQLHLHWGSP--EGPGSEHTVDGRRYDGEIHVVYYNP-SSGSIKE Latimeria_chalumnae_CAIX SM-TIHDSFEQLYRAAQLHFHWGSK--GEPGSEHMVDGKRFPAEIHVVHFAD-KYGSLKE Danio_rerio_CAIX SM-RIRRGFDQVYVAAQLHFHWGTT--EVPGSEHTIDNIHYPAEIHVVHYNS-KYANLTE Homo_sapiens_CAXII DM-HIQGLQS-RYSATQLHLHWGNP-NDPHGSEHTVSGQHFAAELHIVHYNSDLYPDAST Mus_musculus_CAXII DM-YIQGLQPHHYRAEQLHLHWGNR-NDPHGSEHTVSGKHFAAELHIVHYNSDLYPDFST Monodelphis_domestica_CAXII NM-NIQGLGS-RYTATQLHLHWGNR-NNPHGSEHTVDGKHFAAELHIVHYNSDKYPDVVT Meleagris_gallopavo_CAXII TM-HIRNLPF-EYTASQLHLHWGNR-NKSEGSEHTVSGKHFAAEMHIVHYNSEKYPDITT Xenopus_tropicalis_CAXII TM-QIKIAPF-HYTASQLHLHWGQR-GTQKGSEHCIEGKRFAGEVHLVNYNSDKYSDITT Latimeria_chalumnae_CAXII SM-YLNGLPY-RYSATQLHLHWGNK-YSSKGSEHTINGKRFAAELHILHFNSERYPSELI Danio_rerio_CAXII HM-YISSLPH-RYSAAQLHFHWGSS-NLLTGSEHTVNGKQFAGEMHVVHFNSDKYPNVSM Homo_sapiens_CAXIV TL-YLGGLPR-KYVAAQLHLHWGQK-GSPGGSEHQINSEATFAELHIVHYDSDSYDSLSE Mus_musculus_CAXIV TL-HLGGLPR-KYTAAQLHLHWGQR-GSLEGSEHQINSEATAAELHVVHYDSQSYSSLSE Monodelphis_domestica_CAXIV TL-YLGGLPR-NYVAVQLHLHWGRK-GQPGGSEHQVNSEATAAELHIVHYDADSFNELNE Meleagris_gallopavo_CAXIV TL-HLEGLPR-SFAAAQLHFHWGHS-GHPEGAEHLLDGRRAPAEMHLVHYDAERYANASE Xenopus_tropicalis_CAXIV SM-TLRGLPN-TFKAAQLHLHWGSP-AKQAGSEHRLDGEEFPAELHIVHYNSDKYADISE Latimeria_chalumnae_CAXIV SM-WLQGLPA-RYTAVQLHLHWGSE-GYPGGSEHLLDGEVFPAEMHVVHYNSEKYSNISA Danio_rerio_CAXIV WM-GVGGLPS-HYSAVQLHLHWGNGVGIATGSEHTINGQSTSAELHIVHYNTEVYANLSE Drosophila_melanogaster_CAH1 SELTGGPLGDQIFKLEQFHCHWGCT--DSKGSEHTVDGVSYSGELHLVHWNTTKYKSFGE : :* *** *:** :. * *.: Homo_sapiens_CAVI AQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQH Mus_musculus_CAVI AKDQKNGLAVLAVLFKIDEYAENTYYSDIISALKNIEKPGETTTLKDTTIRNLLPKDVHH Equus_caballus_CAVI AKDEPDGLAVLAVLVEVSDYAENTYYSKFLSHLSEVRYSGQSTVLSGLNIQDMLPKDLRY Gallus_gallus_CAVI AKDKPNGLAVLAFLYVEGH-LENTYYSEFISKLAKIRFAGQSTKLTSLDVQAMLPENLSH Meleagris_gallopavo_CAVI AKDKPNGLAVLAFLYVEGH-LENTYYSEFISKLAKIRFAGQSTKLTSLDVQAMLPENLSH Xenopus_tropicalis_CAVI AKDKPNGLAVLAFLYTTGN-YENTYYSDFISKLSKIRYAGQETEMHTLDVMAMLPENLGN Danio_rerio_CAVI AKNKPDGLAVLAFFFEDGH-FENTYYSDFISNLANIKYVGQSMSISNLNVLSMLSENLSH Homo_sapiens_CAIX ALGRPGGLAVLAAFLEEGP-EENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSR Mus_musculus_CAIX ALGRPGGLAVLAAFLQESP-EENSAYEQLLSHLEEISEEGSKIEIPGLDVSALLPSDLSR Monodelphis_domestica_CAIX ALGQPGGLAVLAAFLQEGP-EENDAYEQLLSHLGEIGEEGSETWVQGFDVAALLPHNLQR Gallus_gallus_CAIX AVTQPDGLAVLGVFLEVGP-RENPYYQQILEHLRSIQEEDGEVFVPGFNIAGLLPDNLHL Chrysemys_picta_bellii_CAIX AMRQPGGLAVLAAFLQVGP-EDNVHYQPLLEQLHKVQEEGTERTVAGFNIEGLLPTNLSR Latimeria_chalumnae_CAIX AANKSDGLAVLGVFLEVGS-RTNPFYEKLFSYLQAVSEEGDQHEIPPFDIRGLLPDHLER Danio_rerio_CAIX AASKADGLAVLGGFIAIGL-HENDNYEKILSALSDVSTEESLTVIPGFNVRHLLPNSLER Homo_sapiens_CAXII ASNKSEGLAVLAVLIEMGS--FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAE Mus_musculus_CAXII ASDKSEGLAVLAVLIEIGS--ANPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGE Monodelphis_domestica_CAXII ARDEPEGLAVLAVLIEIGS--FSPSYDNIFSHLQNVKYKDQKVQVPGFNIQDLLPENVHE Meleagris_gallopavo_CAXII AMDKANGLAVLAILLEIGP--FNPSYEKIFRHFRNVKYKDQMVHVPGFNVQELLPDRPDE Xenopus_tropicalis_CAXII AMKESDGLAVLGILLEVGP--FNPTFEKIISQLHSIGYKDQSVQIAGFNVQELLPKRLDE Latimeria_chalumnae_CAXII AMDKSDGLAALGVLIEIGA--FNPAFENIVKYLQNVKYRGQQFPIPGFDIEELLPPRLDE Danio_rerio_CAXII AVDKHDGLAVLGVFIEIGE--ANPAFDKLFRFISGVKYRDQKIQVPAFNIRALLPDRLDQ Homo_sapiens_CAXIV AAERPQGLAVLGILIEVGE-TKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQ Mus_musculus_CAXIV AAQKPQGLAVLGILIEVGE-TENPAYDHILSRLHEIRYKDQKTSVPPFSVRELFPQQLEQ Monodelphis_domestica_CAXIV AAQKPQGLAVLGILIEVGE-NQSPAYEHLLSHLEKIRHKGQTTLVPPFDVGGLLPPEMGE Meleagris_gallopavo_CAXIV AQHHAAGLAVLGILLEVGD-EPNAAYANILNHLGSIRYAGQTTSIPSFSVQELLPERLDR Xenopus_tropicalis_CAXIV AKNKPDGLAVLGVFFEIGA-TDNPAYANILHHLDNIRYKDQTVSVPSFNVRHLLPENLEE Latimeria_chalumnae_CAXIV AKDKPDGLAVLGILLEAGD-TVNAAYEHIFRYLGNVKYAGEKVVVPPFDVRTLLPPRLDH Danio_rerio_CAXIV AMMQKNGLAVLGILIETGE-EVNQAYGSIFNYLGRIRYAGQKVAIPSFDLQSLLPENLSQ Drosophila_melanogaster_CAH1 AAAAPDGLAVLGVFLKAGN--HHAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLPDVHT * ***.*. : . : : : : Homo_sapiens_CAVI YYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHR----N-----KTIHND Mus_musculus_CAVI YYTYPGSLTTPPCTENVQWFVLRDKVTLSKAQVVTIENSVMDHN----N-----NTIQNG Equus_caballus_CAVI YYSYQGSLTTPPCTENVQWFLLADPVKLSKSQVLKLENSLLDSQ----N-----KTLNNG Gallus_gallus_CAVI FYRYQGSLTTPPCSESVTWTIFDSPIVLSHTQIGLLENTLLNWH----N-----RTLRND Meleagris_gallopavo_CAVI FYRYQGSLTTPPCSESVTWTVFDSPIILSHAQIGLLENTLLDWH----N-----RTLRND Xenopus_tropicalis_CAVI FYRYSGSLTTPPCTENVLWTVFDSPVYLSKTQIDLLENTLLDWH----N-----KTLRND Danio_rerio_CAVI FYRYKGSLTTPPCFESVMWTVFDTPITLSHNQIRKLESTLMDHD----N-----KTLWND Homo_sapiens_CAIX YFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPG----D-----SRLQLN Mus_musculus_CAIX YYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQLHTLSVSLWGPR----D-----SRLQLN Monodelphis_domestica_CAIX YFRYKGSLTTPPCSQGVIWTVFNQTVLLSAGQLRTLSLSLWGPE----G-----SRLQRN Gallus_gallus_CAIX YFHYNGSLTTPPCLESVKWTVFNQTVMLSKEQMSVLVSSLQTDD----N-----HLLMNN Chrysemys_picta_bellii_CAIX YYRYSGSLTTPPCYQTVNWTVFNQTVLLSKEQISLLETTLQGDD----D-----KDLQNN Latimeria_chalumnae_CAIX YFRYNGSLTTPPCFQSVTWTVFNNTIQISQDQLSQLENTLKMKH----Q-----QILSQN Danio_rerio_CAIX FYRYSGSLTTPPCLQTVSWTLFNDSIRVSRRQLAALEESLKTEH----N-----KLLSKN Homo_sapiens_CAXII YYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDP----SPREMINN Mus_musculus_CAXII YYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDP----TPREMINN Monodelphis_domestica_CAXII YYRYQGSLTTPPCSPTVLWTVFRNPVQISKEQLLALETALYCTHIDDP----SPLEMVNN Meleagris_gallopavo_CAXII YYRYEGSLTTPPCYPSVLWTVFRHPVKISQEQLLALETAMYCTESDDP----EPLEMVNN Xenopus_tropicalis_CAXII YYRYEGSLTTPPCYPSVLWTVFRNPVTISEEQLITLETALYSTDR--N----ESVQMTNN Latimeria_chalumnae_CAXII FYRYEGSVTTPPCYTSVIWTVFRNTVKISREQLLTLQTSMYYTQKDEP----APLEMMDN Danio_rerio_CAXII YYRYDGSLTTPPCYPSVLWTVFRKPVTISRKQFLALATALYASFAQDS----PSMPLHEN Homo_sapiens_CAXIV YFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEE-EP----S-KLLVQN Mus_musculus_CAXIV FFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSSTEE-DP----S-EPLVQN Monodelphis_domestica_CAXIV FYRYNGSLTTPPCYQSVLWTVFHRKAQISMGQLEKLQETLFSTEETRP----P-QSLVQN Meleagris_gallopavo_CAXIV YYRYNGSLTTPPCLQSVLWTVFQQPVRISAAQLEQLQGSLYATAVDEP----SAERLEDN Xenopus_tropicalis_CAXIV YFRYQGSLTTPPCFQSVLWTVFYHPVEISRSQLEKLQTTLYSTTATEV----PPEVLGNN Latimeria_chalumnae_CAXIV YYRYNGSLTTPPCYQSVLWTVFKQQVQISWTQLDKLQRALFSTDTEKY----PAIPLVDN Danio_rerio_CAXIV YFRYNGSLTTPPCHESVLWTIFNERVKISHSQLLKLETVLYSSKAEEE----EPTILQDN Drosophila_melanogaster_CAH1 YWTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGKVINN :: * **:***** * * :: :* *. : : Homo_sapiens_CAVI YRRTQPLNHRVVESNF---PNQE-YTLGS----EF----------------------QFY Mus_musculus_CAVI YRSTQPNNHRVVEANFLNVQDMY-----S----SY----------------------HLY Equus_caballus_CAVI YRSTQHLNGRVVETNFIYHPNQQ-SVLGS----EL----------------------QFH Gallus_gallus_CAVI YRHAQPLHGRVVEASFQARPKQ-EQCQPE----EL----------------------SHK Meleagris_gallopavo_CAVI YRHAQPLHGRVVEASFQARPRQ-EQCQPE----EL----------------------SLK Xenopus_tropicalis_CAVI YRHAQPLYDRTVEASFHPKMPK-DSCQLE-----I----------------------SNK Danio_rerio_CAVI YRMAQPLNERVVESTFLPRLSKGGMCRQE----EI----------------------EAK Homo_sapiens_CAIX FRATQPLNGRVIEASFPAGV---DSSPRA---AEP---VQLNSCLAAGDILALVFGLLFA Mus_musculus_CAIX FRATQPLNGRTIEASFPAAE---DSSP------EP---VHVNSCFTAGDILALVFGLLFA Monodelphis_domestica_CAIX FRATQPLNGRMIEASFPPPTATAHNPPDS---PEP---VHSSSCLNVGDILALLFGLLFA Gallus_gallus_CAIX FRQDQSLHRRWVLASFEPSSSRDRQVPAGGGSSVT---AGHTSSFHAGDVLAVLFGVLFA Chrysemys_picta_bellii_CAIX FRLTQSLHGRKVLANFQASLSPR-RVPLPGGRETC---PWGDMSLHGAEVLAGLFGVLFA Latimeria_chalumnae_CAIX FRVPQSLHGRKVLASFNLSFKTRRMGDPGAEAQD--------ELSSRGNTLAIIFGCLFG Danio_rerio_CAIX FRAPQLLHGRKIQSSFHTSDSGKTRGATPTETQDKNIKESSAHPSLTGHILAVTFGVLFA Homo_sapiens_CAXII FRQVQKFDERLVYTSFSQVQVCT--------------AA----GLSLGIILSLALAGILG Mus_musculus_CAXII FRQVQKFDERLVYISFRQGVLLT--------------NT----GLSLGIILSVALAGVLG Monodelphis_domestica_CAXII FRRVQKFDERLVRVSFHQGNVML--------------KYFVLILSSPGVILSVAIAGVLG Meleagris_gallopavo_CAXII FRNVQEFRERLVFISFHEDYKLC--------------SV---SPFLLGVLVSVVIACVVG Xenopus_tropicalis_CAXII YRQLQPHGDRLVSVSFREG-----------------------------VVLTIALACLLG Latimeria_chalumnae_CAXII YRHTQEPGDRIVFITFRQG-----------------------------IVLSLILAGALG Danio_rerio_CAXII YRKSQLPDNRVVLVSFREG-----------------------------IIASITAASMLG Homo_sapiens_CAXIV YRALQPLNQRMVFASFIQ-AGS---------------------SYTTGEMLSLGVGILVG Mus_musculus_CAXIV YRVPQPLNQRTIFASFIQ-AGP---------------------LYTTGEMLGLGVGILAG Monodelphis_domestica_CAXIV YRAPQPLNHRLVVASFIP-EGA---------------------FYSTGEMVGLGLGILFG Meleagris_gallopavo_CAXIV FRDPQDLNQRPVLASFTS-SPQ---------------------GYSTGEVIAIVFGTVLG Xenopus_tropicalis_CAXIV VREAQLLNSRTVYSSFHIHSTFA--------------------TGTVGNILAIIFGIFLG Latimeria_chalumnae_CAXIV FRAPQPLNHRTVYASFPLGSTS---------------------AYSTGEIIAIVFGLLFG Danio_rerio_CAXIV YRATQPLNHRTVLSSFIPVSVQ---------------------IYTAGEIAAIVIGSLFG Drosophila_melanogaster_CAH1 FRPPLPLGKRELREIGGH------------------------------------------ * * : Homo_sapiens_CAVI LHKIEEILDYLRRALN-------------------------------------------- Mus_musculus_CAVI LKNMQKEILQP---KKQ------KKTKKNRHFWSRK------------------------ Equus_caballus_CAVI LTRIDNNLEYFRRLIEQ------KQVKRK------------------------------- Gallus_gallus_CAVI LEQIQTQLQDMKKEFLN--------GVSHTG----------------------------- Meleagris_gallopavo_CAVI LEQIQTQLRDMKKEFLN--------GVSHTG----------------------------- Xenopus_tropicalis_CAVI LRLIATELEDIKKRADS--------SKSSRMLM--------------------------- Danio_rerio_CAVI LKRIESLILSLDKKAVQ--------G---------------------------------- Homo_sapiens_CAIX VTSVA-FLVQMRRQH-------RRGTKGGVSYRPAEVAETGA------------------ Mus_musculus_CAIX VTSIA-FLLQLRRQH-----RHRSGTKDRVSYSPAEMTETGA------------------ Monodelphis_domestica_CAIX VTSVA-FLVYMRRQK-----RLSRVAKENVIYHPTEVTETAT------------------ Gallus_gallus_CAIX ITMLA-FLLYVYKNRSQN-ARLDSPTKSKVIYTAATAENTA------------------- Chrysemys_picta_bellii_CAIX VTALA-FLIYIYKQQSQN-RRPDSHPKPNVIYTAATTDENA------------------- Latimeria_chalumnae_CAIX ITLLA-FIIYVMHHRKMN-QRSKKETHSNVIYKAATSTEEA------------------- Danio_rerio_CAIX ATFLI-FSIYTYRQHKKY-SKFKKDSKQDVIYKPAPIGKDTDQTTVTVS----------- Homo_sapiens_CAXII ICIVVVVSIWLFRRKSI--K--KG-DNKGVIYKPATKMETEAHA---------------- Mus_musculus_CAXII ISIVLAVSIWLFKRKKS--K--KG-DNKGVIYKPAIKKEAEVHA---------------- Monodelphis_domestica_CAXII VAVILALSIWLLRKKKS--K--KE-DNKGVIYKPALKKEADINP---------------- Meleagris_gallopavo_CAXII VLIFLVVVCCLCRRKSC--K--KE-ESREVTYTQGMHQKEAAIS---------------- Xenopus_tropicalis_CAXII VLVIIAVTCLLIRRKRR--SKKSS-DSRNIAYTAAAGVEENTSKV--------------- Latimeria_chalumnae_CAXII ALVVIAIVCFVLQRNRA--KKQTA-EIKGIIYKSTPSKDEENPKI--------------- Danio_rerio_CAXII LLMIITLVWCILRKR--------------------------------------------- Homo_sapiens_CAXIV CLCLLLAVYFIARKIRK--KRLENRKS--VVFTSAQATTEA------------------- Mus_musculus_CAXIV CLCLLLAVYFIAQKIRK--KRLGNRKS--VVFTSARATTEA------------------- Monodelphis_domestica_CAXIV CLCLLLAGYFIARKIRR--NRLGQQKS--VVFTSSRRATTDE------------------ Meleagris_gallopavo_CAXIV SLGLFLTVHFVNKRLR-------------------------------------------- Xenopus_tropicalis_CAXIV VVAIGFVIYCIYKQTRK--VTSGAPHDKASMSPT--VPT--------EVRSV-------- Latimeria_chalumnae_CAXIV TFGLIMASFFIVRRLQL--KKKKKKGQKIIVCTCCLYFF--------VV----------- Danio_rerio_CAXIV CIGLAVIIWFIVKTIRL--TSSWDVLQSIQPAPQPRMQDANEHKQDTDLKMTSNQEKTKD Drosophila_melanogaster_CAH1 ------------------------------------------------------------ * Homo_sapiens_CAVI ------- Mus_musculus_CAVI ------- Equus_caballus_CAVI ------- Gallus_gallus_CAVI ------- Meleagris_gallopavo_CAVI ------- Xenopus_tropicalis_CAVI ------- Danio_rerio_CAVI ------- Homo_sapiens_CAIX ------- Mus_musculus_CAIX ------- Monodelphis_domestica_CAIX ------- Gallus_gallus_CAIX ------- Chrysemys_picta_bellii_CAIX ------- Latimeria_chalumnae_CAIX ------- Danio_rerio_CAIX ------- Homo_sapiens_CAXII ------- Mus_musculus_CAXII ------- Monodelphis_domestica_CAXII ------- Meleagris_gallopavo_CAXII ------- Xenopus_tropicalis_CAXII ------- Latimeria_chalumnae_CAXII ------- Danio_rerio_CAXII ------- Homo_sapiens_CAXIV ------- Mus_musculus_CAXIV ------- Monodelphis_domestica_CAXIV ------- Meleagris_gallopavo_CAXIV ------- Xenopus_tropicalis_CAXIV ------- Latimeria_chalumnae_CAXIV ------- Danio_rerio_CAXIV TEHQPET Drosophila_melanogaster_CAH1 -------