CLUSTAL O(1.1.0) multiple sequence alignment Taeniopygia_guttata ----M---LMAALLLCLLLVPLSHCHEVPWTYTG-EGELDEEHWGQHFPDCAGQQQSPID Takifugu_rubripes MEQ---ICVFASALFFCVVSAGVHLDGIHWTYT--EGALDQMHWPTKYPACGGKQQSPID Gasterosteus_aculeatus MEF---FLVMVSSALVCAVSAGIPHDGIHWTYA--EGALDQMHWPTKYPACGGKKQSPID Tetraodon_nigroviridis MEL---ILVFVSA-LVCVVNAGVHLDGIHWTYK--EGALDQMHWPTKYPACGGKKQSPID Latimeria_chalumnae ---IG---TLQILGLLLYIVQTAIFHEINWTYE--EGEMDEKHWSLKYPACSGKHQSPID Danio_rerio MEQLTLVLLFVTS--LNF--ASAGVDGDYWTYS---GELDQKHWAEKYHDCGGQQQSPID Meleagris_gallopavo ----M---LIPTAL--LLLQLLSCSHAVHWTYR--EGELDEEHWGLHFAACAGKQQSPID Oryzias_latipes MEV---LSAILSALLLRFVA---ADNRIHWTYT--EGALDQQHWATEYPACAGKKQSPID Gallus_gallus ----M---LIPTAL--LLLQLLSCSHAVHWTYR--EGELDEEHWGLHFAACAGKQQSPID Gadus_morhua -----------------------------------EGALDQARWPLKYPACGGQKQSPID Xenopus_tropicalis MARLL---QLGLYLFLVLACHLTTSHVVEWTYQ--EGEVDEANWGKKYPVCALRHQSPID Ochotona_princeps ----MRSLVT---LLVLFLLGIQADQGPEWTYS--EG-----SWATEYPACDGWRQSPID Macaca_mulatta ----MRALVP---LLSLFLLGGQAQHGSDWTYS--EGALDEAHWPQHYPACGGQRQSPIN Pan_troglodytes ----MRALVL---LLSLFLLGGQAQHGSDWTYS--EGALDEAHWPQHYPACGGQRQSPIN Echinops_telfairi ----MRAVAI---LLS-LFLGVSAQHGSQWSYS--EGALDQERWAEQYPTCGGKRQSPIN Sus_scrofa ----MTALVT---LLFLLLLGAQTQHGAEWTYS--DGELDEAHWSREYPDCDGRRQSPID Ailuropoda_melanoleuca ----MAALAL---LLALLPLGAWAQHGSGWTYS-A-GTLDEAHWPREYPTCGGMRQSPIN Myotis_lucifugus ----MRTLI----ILPLLLLGALA--HQDWTYTASEGPHDETHWPEAYPTCGGHRQSPID Homo_sapiens ----MRALVL---LLSLFLLGGQAQHVSDWTYS--EGALDEAHWPQHYPACGGQRQSPIN Tursiops_truncatus ----MTALVT---LLSLLLLGPQAQHGTEWTYS--DGVLDEAHWPREYPDCGGKRQSPID Bos_taurus -------MIT---LLFLLVVGAQAQH--EWTYS--EGVLDEKHWRLQYPDCGGTRQSPID Erinaceus_europaeus ----MTPLIL---VLSLFLLGVQALHGSQWTYS--EGTLDEEHWSSEYPTCGKKKQSPIN Rattus_norvegicus ----MRVLVS---VVSLFFLGIQA--LSEWSYSGD-DGLEESRWPEKYPSCGGERQSPID Oryctolagus_cuniculus ----MRALGT---LVALLLLGSQAHSEPEWTYS--EGALEEESWPLEYPACGGHRQSPIN Gorilla_gorilla ----MRALVL---LLSLFLLGGQAQHGSDWTYS--EGALDEAHWPQHYPACGGQRQSPIN Nomascus_leucogenys MCSTMRALVL---LLSLFLLGGQAQHGSDWTYS--EGALDEAHWPQHYPACGGQRQSPIN Ornithorhynchus_anatinus ------------------------------------------------------------ Spermophilus_tridecemlineatus ----MRVVVT---LVSLLLLGARAQH--EWSYSASEGGLEEDLWPQEYPACGGHRQSPID Canis_familiaris ----MRALAL---LLALPLLGARAQHGSLWTYS-AEGALDQVHWPREYPTCGGTRQSPID Otolemur_garnettii ----MRALVP---LLSLLLLGTQAQHGSEWTYSVSEGALDQAHWPKEYPACGGKRQSPIN Cavia_porcellus ----MATLVT---LVSLLLLGFQAQVRSEWTYS--EGQLDEEHWALHYPACGGTRQSPIN Pongo_abelii ----MRALVL---LLSLFLLGGQAQHGSDWTYS--EGALDEVHWPQHYPACGGQRQSPIN Equus_caballus ----MQAPLT---LLSLLLLGAQA--GQHWTYS--DGELDEAHWSNEYPTCGGDRQSPID Loxodonta_africana ----MRVLAI---LLS-LFLGALAQHGSEWTYS--EGALDQEHWPSYYPACGGKRQSPHH Mus_musculus ----MRALVS---VVSLFFLGIQA--HSDWSYSGD-DGVGESQWSEQYPSCGGERQSPID Taeniopygia_guttata IQRRKV-RY-NPLLQLELGGYEGPLQGQLRMTNNGHSVQIDLPPTMNISRGLPGVYTAVQ Takifugu_rubripes IQRRNV-RFNPDMLQLKLSGYNA-QRGDFLMTNNGHTVQIDLPPTMMITEGLPGKYTAVQ Gasterosteus_aculeatus IQRRSV-RHNPDMLQLELNGYDA-LEGKFLMSNNGHSVQIDLPPSMAITKGLPGKYTAVQ Tetraodon_nigroviridis IQQRNV-RFNPDMLQLELSGYDA-QQGTFLMTNNGHTVQIDLPPTMVITEGLPGKYTAVQ Latimeria_chalumnae IQRKKV-KYSPDFKKLVLNGYDGSQNGAFKMTNNGHSVQIDLPPTMNISEGFTSNYTAVQ Danio_rerio IQRRKV-RYSPRMQQLELTGYED-IRGSFLMKNNGHSVEIQLPSTMKITKGFPHQYTAVQ Meleagris_gallopavo IQRKKV-VHNVQLLQLELSGYSRPLQGDFTMTNNGHSVQIDLPPTLSISRGLPHPYTAVQ Oryzias_latipes IQRRNV-KHNPNMLQLELSNYDA-QQGKFLMTNNGHTVQINLPPTMTISQGLPGIYTAVQ Gallus_gallus IQRRNV-VHNAQLLQLELSGYSRPLQEDCTMTNNGHSVQIDLPPTLSISRGLPRPYTAVQ Gadus_morhua IQRRNV-RHNPQMLQMELRGYDA-QKGNFLMTNNGHSVQIDLPPTMVISEGLPGRYTAVQ Xenopus_tropicalis IQRKKV-RHNPELAQLELIGYDGPLTGHFKVTNNGHSVQIDLPPSMTIKKGLNSLYTAVQ Ochotona_princeps LQRKKA-QFNPQLKALNLMGYDT-ASDSFSMTNNGHTVQVSLSPSMSMTTPDGTEYIAKQ Macaca_mulatta LQRTKV-RYNPALKGLKLTGYET-QEGEFPMVNNGHTVQISLPSTMRMTAADGTVYIAQQ Pan_troglodytes LQRTKV-RYNPSLKGLNLTGYET-QAGEFPMVNNGHTVQISLPSTMRMTAADGTVYIAQQ Echinops_telfairi LQKKLI-EYNPTLKGLNLVGYEA-QNLKFSMINNGHTVQISLPQTMHMTTADGTVYMAQQ Sus_scrofa VQRKSV-QYNPALRALSLTGYEA-QEGEFSMINNGHTVQISLPSTMRLTAPDGTQYIAKQ Ailuropoda_melanoleuca LQWRKV-QYNPSLKALNLTGYDV-QAGEFPMINNGHTVQISLPPTMRMTATDGTVYIAEQ Myotis_lucifugus VQRKKV-RYNPSLKALNLTGYEA-QGGDFLMTNNGHTVQISLPPTMRMTTAEGTEYIAVQ Homo_sapiens LQRTKV-RYNPSLKGLNMTGYET-QAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQ Tursiops_truncatus LQREKV-WYNPSLRALNLSGYEV-QHGAFLMINNGHTVQISLPPTMCMTAANGTQYIAQQ Bos_taurus LKMKKV-RYNPSLRALNLTGYGL-RQGEFPMTNNGHTVQISLPSSMRMTTSDGSQYLAKQ Erinaceus_europaeus VQRSKV-QYNPNLKPLILVGYEA-QNAPFTMINNGHTVQISLYHTMHMIVPDGTRYIAQQ Rattus_norvegicus VKRREV-HFSSSLLPLHMVNYEE-EGLELSMTNNGHTVQITLPNTMSMRDSDGTVYRTKQ Oryctolagus_cuniculus LQRKKV-QYNPSLQVLELKGYDT-PTGEFSMINNGHTVQVSLPPTMRMTTSDGTEYIALQ Gorilla_gorilla LQRTKV-RYNPALKGLNLTGYET-QAGEFPMVNNGHTVQISLPSTMRMTAADGTVYIAQQ Nomascus_leucogenys LQRTKV-RYNPALKGLNLTGYET-QAGEFPMVNNGHTVQISLPSTMRMTAADGTVYIAQQ Ornithorhynchus_anatinus -------------------------------------VQINLPPTMQITNGLPGTYTAVQ Spermophilus_tridecemlineatus LQQNKV-RFNPALKALNLTGYQEDRGDEFTMINNGHTVQINLPPTMRMMAPDGTEYIAKQ Canis_familiaris LQRRKV-QYNPSLKALKLTGYRI-QVGEFPMINNGHTVQISLPPTMRMMASDGTEYIAQQ Otolemur_garnettii LQTRKV-HYNPSLKALNLTGYDT-QEGEFSMVNNGHTVQISLPPTMHLRAPDGTKYIAQQ Cavia_porcellus LQRRKV-HFNPALTPLELMGYEEGQAGQFPMTNNGHTVQITLPESMRLAGPEGTEHVAVQ Pongo_abelii LQRTKV-RYNPALKGLNLTGYKT-QAGEFPMVNNGHTVQISLPSTMRMTAADGTVYIAQQ Equus_caballus LQSKKM-RYNPSLKPLTLVGYED-QEGEFSMTNNGHTVQISLRPTMHMEAADGTKYVAEQ Loxodonta_africana PAEENGGGTTPTFDGTSPINIKS-LLLRFLSNFSSHCCQIKLPSTMRLAASDDTEYIAEQ Mus_musculus VKTEEV-MFNPSLKPLSLVNYEK-ENLEFTMTNNGHTVSIDLPPSMYLETSDGTEFISKA .: * :: : . : Taeniopygia_guttata MHLHWGGLDLESSGSEHTIDGMRYFAELHIVHYDSANYSSFEEAKDKPQGLAVLAFLYTD Takifugu_rubripes MHLHWGGWDLEASGAEHTIDGIRYMAELHVVHYNSDKYKSFIEARDKPDGLAVLAFFYDD Gasterosteus_aculeatus MHLHWGGWDLEASGAEHTIDGIRYMAELHVVHYNSDKYSSFTDARDKPDGLAVLAFFYDD Tetraodon_nigroviridis MHLHWGGWDLEASGAEHTIDGVRYMAELHVVHYNSDKYKSFIEARDKPDGLAVLAFFYDD Latimeria_chalumnae MHFHWGGLEQESSGSEHTVDGMRYLAELHIVHYNSDKYSKFDDAKDKPDGLAVLAFFYED Danio_rerio MHLHWGGWDLEASGSEHTMDGIRYMAELHVVHYNSEKYPSFEEAKNKPDGLAVLAFFFED Meleagris_gallopavo MHLHWGGLDLETSGSEHTLDGMRYVAELHIVHYNSADYSSFEEAKDKPNGLAVLAFLYVE Oryzias_latipes MHLHWGGSHQEASGAEHTIDGVRYMAELHIVHYNSEKYRSFSEAKDKKDGLAVLAFVYDD Gallus_gallus MHLHWGGLDLETSGSEHTLDGMRYVAELHIVHYNSADYSSFEEAKDKPNGLAVLAFLYVE Gadus_morhua MHLHWGGWDLEESGAEHTLDGIRYMAELHVVHYNSDKYKSFKEARDKPDGLAVLAFFYED Xenopus_tropicalis MHLHWGGLESETSGSEHTIDGMRYLAELHVVHYNSGTYKTFDEAKDKPNGLAVLAFLYTT Ochotona_princeps MHFHWGGASAEVGGSEHTVDGIRRVIEVHVLHYNS-KYDSYDKAQREPDGLAVIAAFIEI Macaca_mulatta MHFHWGGASSKIRGSEHTVDGIRHVIEIHVVHYNS-KYKSYETAQDAPDGLAVLAAFVEV Pan_troglodytes MHFHWGGASSDISGSEHTVDGIRHVIEIHVVHYNS-KYKSYDIAQDAPDGLAVLAAFVEV Echinops_telfairi MHFHWGGGSSEMRGSEHTIDKKRYMIEAHVVHYNS-NYKNYDVAKDHPDGLAVLAFFFVE Sus_scrofa MHFHWGGAFSEISGSEHTIDGIRYVTEVHVVHYNS-KYKSYDEAQTAPDGLAVLAALFEI Ailuropoda_melanoleuca MHFHWGGASSEISGSEHTIDGIRFVAEIHIVHYNS-KYKSFAIAQSEPDGLAVLAALVKV Myotis_lucifugus MHFHWGGAALEVSGSEHTIDGLRYAAEIHVVHYNS-KYESYDTAKDAPDGLAVLAALIEV Homo_sapiens MHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNS-KYKSYDIAQDAPDGLAVLAAFVEV Tursiops_truncatus MHFHWGGASLEISGSEHTIDGIRYVMEIHVVHYNS-KYKSYDQAQKAPDGLAVLAALVEV Bos_taurus MHFHWGGASSEISGSEHTVDGMRYIIEIHVVHYNS-KYGSYEEAQNEPDGLAVLAALVEV Erinaceus_europaeus MHFHWGDASSEISGSEHTIDGTRYVAEAHLVHYNS-KYHSFEEAQNAPDGLAVLAFFLKI Rattus_norvegicus MHFHWGGRDSEISGSEHTIDGMRHAIEIHLVHFNE-KYETYEKAVDQPDGLAVMAVLVKV Oryctolagus_cuniculus MHYHWGGASSEVSGSEHTVDGIRRVIEVHVVHYNS-KYESYDVAKDASDGLAVLAAFIEI Gorilla_gorilla MHFHWGGASSEISGSEHTVDGIRHVIEIHVVHYNS-KYKSYDIAQDAPDGLAVLAAFVEV Nomascus_leucogenys MHFHWGGASSEISGSEHTVDGIRHVIEIHVVHYNS-KYKSYDIAQDAPDGLAVLAAFVEV Ornithorhynchus_anatinus LHFHWGGQSSETSGSEHTMDGMRHIAELHIVHYNSDQYASYEDALHQPNGLAVLAALFVA Spermophilus_tridecemlineatus MHYHWGGGSSEVSGSEHTIDGIRHVIEIHVVHYNA-KYDSYDIAKDASDGLAVLAAFVEV Canis_familiaris MHFHWGGASSEISGSEHTIDGIRFVAEIHIVHYNS-KYKSYDIAQHEPDGLAVLAALVKV Otolemur_garnettii MHFHWGGGSSEMSGSEHTVDGARHMSEIHVVHYNS-KYQSYDIAKDAPNGLAVMAAFIEV Cavia_porcellus MHFHWGGDSFEVSGSEHTVDGVRRVMEIHVVHYNS-KYESYDIAKDAPDGLAVLAAFVEM Pongo_abelii MHFHWGGASSEISGSEHTVDGIRHVIEIHVVHYNS-KYKSYDIAQDAPDGLAVLAAFVEV Equus_caballus MHFHWGGGASEISGSEHTIDGIRYVTEIHLVHYNS-KYGSYDIAKDEPDGLAVLAVLVEV Loxodonta_africana MHFHWGGGSLEMSGSEHTIDGRRFLIEIHVVHYNS-KYKSYNIAKDAPDGLAVIAAFCEV Mus_musculus FHFHWGGRDWELSGSEHTIDGIRSIMEAHFVHFNK-EYGTYENAKDQKNGLAVLAVLFKI :* *** . *:***:* * * *.:*:: * .: * :****:* . Taeniopygia_guttata G--HFENTYYSEFISKLARIRFA-GQSTTLSSLDIQAMLPENLSHFYRYQGSLTTPPCSE Takifugu_rubripes G--HFENTYYSDFISNLGKIKYA-GQSMNISSLDMRSMLPENLNHFFRYQGSLTTPPCYE Gasterosteus_aculeatus G--HFENTYYSDFINNLEKIKYA-GQSMHISSIDVRSMLPENINHFFRYQGSLTTPPCYE Tetraodon_nigroviridis G--HFENTYYSDFIANLGKIKYA-GQSMYISSLDVRSMLPENLNHFFRYQGSLTTPPCYE Latimeria_chalumnae G--HFENTYYTDFISHLAKIRFA-GQYTHLTLINVRDMLPEDLSHFYRYKGSLTTPPCYE Danio_rerio G--HFENTYYSDFISNLANIKYV-GQSMSISNLNVLSMLSENLSHFYRYKGSLTTPPCFE Meleagris_gallopavo G--HLENTYYSEFISKLAKIRFA-GQSTKLTSLDVQAMLPENLSHFYRYQGSLTTPPCSE Oryzias_latipes G--HFENTYYSDFIANLEKIKYAAGQSMNITSIDVRSMLPENLNHFFRYEGSLTTPPCFE Gallus_gallus G--HLENTYYSEFISKLAKIRFA-GQSTKLTSLDVQAMLPENLSHFYRYQGSLTTPPCSE Gadus_morhua G--HFENTYYSDFISNLARIKYA-GQAMNISHINVRSMLPENINHFFRYQGSLTTPPCYE Xenopus_tropicalis G--NYENTYYSDFISKLSKIRYA-GQETEMHTLDVMAMLPENLGNFYRYSGSLTTPPCTE Ochotona_princeps N-EYAENTYYSQFISRLAEIKHP-GDVTTLENLNVRNMLPEDMSQYYTYLGSLTTPPCSE Macaca_mulatta KD-YPENTYYSSFISHLANIKYP-GQTTTLTGLDIRDMLPKNLQHYYSYDGSLTTPPCTE Pan_troglodytes K-NYPENTYYSNFISHLANIKYP-GQRTTLTGLDIQDMLPRNLQHYYTYHGSLTTPPCTE Echinops_telfairi VHDDAENPHYTEFLSHLKNIRYP-GQSTTLSGFDIKDMLPRNLQDYYTYHGSLTTPPCTE Sus_scrofa K-DYAENTYYSDFISHLKNIRNP-GQTTVLSSLNLQDMLPENLHSYYSYQGSLTTPPCTE Ailuropoda_melanoleuca K-DYGENTYYSDFIAHLNDIQQP-GQSTVLSGLDILDMLPENTHHYYSYQGSLTTPPCTE Myotis_lucifugus K-DYAENTYYSNFISRLEDVTYL-GRSTVLSSLDVQDMLPANLGFYYTYRGSLTTPPCTE Homo_sapiens K-NYPENTYYSNFISHLANIKYP-GQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTE Tursiops_truncatus K-DDAENTYYSNFVSHLKSIRYP-GQSTVLRGLDVQDMLPGNLHYYYSYWGSLTTPPCTE Bos_taurus K-DYAENTYYSNFISHLEDIRYA-GQSTVLRDLDIQDMLPGDLRYYYSYLGSLTTPSCTE Erinaceus_europaeus Q-EYSENLYYSSFISHLNSIKYP-GQSTVIEGLNIMDMMPHNPQHYYTYTGSLTTPPCTQ Rattus_norvegicus E-DYTENDYYSTFISELENVKYT-GQTTTLRNVNIRNMLPGDIRHYYTYQGSLTTPPCTE Oryctolagus_cuniculus N-DYAENTYYSQLISQLANIRYP-GQVTTLRDLNIREMLPENVDHYYTYQGSLTTPPCSE Gorilla_gorilla SRNYPCVSVFEV-IVCYLLSSWS-GQRTTLTGLDIQDMLPRNLQHYYTYHGSLTTPPCTE Nomascus_leucogenys K-NYPENTYYSNFISHLANIKFP-GQRTTLTGLDIQDMLPKNLQHYYTYHGSLTTPPCTE Ornithorhynchus_anatinus G--NAENTYYSQFLKHLANIKYA-GQTANLTSIDVLSMLPENIDDFYRYHGSLTTPPCSE Spermophilus_tridecemlineatus N-EYAENTYYSTFIAHLADIRYP-GQRTILRGLDIQDMLPGDLYHYYTYEGSLTTPPCTE Canis_familiaris E-DYGENTYYSNFISHLNNIRYP-GQSTVLSGLDIEDMLPENTHHYYTYRGSLTTPPCTE Otolemur_garnettii K-DHTENTYYDDFISHLANIKYA-GQSTTLTGLDIKDMLPVDLAHYFSYNGSLTTPPCTE Cavia_porcellus E-EDAENTYYSSFISHLANIKYP-GQSTMISGLPVLDMLPENHFEYYTYHGSLTTPPCTE Pongo_abelii KN-YPENPYYSNFISHLANIKYP-GQTTTLTGLDTQDMLPRNLQHYYSYHGSLTTPPCTE Equus_caballus S-DYAENTYYSKFLSHLSEVRYS-GQSTVLSGLNIQDMLPKDLRYYYSYQGSLTTPPCTE Loxodonta_africana Q-DNTENTYYSELISQLQNIRHP-GQSTTLAGLDIKDMLPENLHDYYTYLGSLTTPPCTE Mus_musculus D-EYAENTYYSDIISALKNIEKP-GETTTLKDTTIRNLLPKDVHHYYTYPGSLTTPPCTE : : * : :: : :: * ****** * : Taeniopygia_guttata SVIWTIFHSPIVLSHT--QVQLLENTLLDWHNRTLRNDYRHAQPLRGRVVEASFRAPRGQ Takifugu_rubripes SILWTVFDTPITLSHN--QIRKLESTLMDLDNKTLWNDYRIAQPLNDRMVESSFLPRLGK Gasterosteus_aculeatus SILWTVFDTPITLSHN--QIRKLESTLMDMDNKTLWNDYRMAQPLNSRVVESSFLPRLGK Tetraodon_nigroviridis SILWTVFDTPITLSHN--QIRKLESTLMDLDNKTLWNDYRIAQPLNDRVVESSFLPRLGK Latimeria_chalumnae SITWTVFDTPILLSYA--QIQLLESTILDWKNKTLRNDYRHAQPLNDRVVKASFQPVFDK Danio_rerio SVMWTVFDTPITLSHN--QIRKLESTLMDHDNKTLWNDYRMAQPLNERVVESTFLPRLSK Meleagris_gallopavo SVTWTVFDSPIILSHA--QIGLLENTLLDWHNRTLRNDYRHAQPLHGRVVEASFQARPRQ Oryzias_latipes SIIWTVFDTPITLSQNQHQIRRLESTLMDIDNKTLWNDYRIAQPLNDRVVESSFLPRVRK Gallus_gallus SVTWTIFDSPIVLSHT--QIGLLENTLLNWHNRTLRNDYRHAQPLHGRVVEASFQARPKQ Gadus_morhua SILWTVFDTPITLSHN--QIRKLESTLMDHNNKTIWNDYRMAQPLNDRVVESSFLPRLGK Xenopus_tropicalis NVLWTVFDSPVYLSKT--QIDLLENTLLDWHNKTLRNDYRHAQPLYDRTVEASFHPKMPK Ochotona_princeps NVLWFVLANPIFLSRV--QVWKIENSLLNHQNHTIQNTYRTTQNLNDRVVEASF------ Macaca_mulatta NVHWFVLADFVKLSRT--QVWKLENSLLDHHNKTIQNDYRRTQPLNHRVVESNFPNQGK- Pan_troglodytes NVHWFVLADFVKLSRT--QVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEY- Echinops_telfairi NVLWFLLAEPVKLPKK--QILKLENSLLDNQNKTLQNAYRLTQPLNDRVVQANFEGHHPM Sus_scrofa NVHWFVLADTVKLSRT--QVWKLQNSLLNDQNKTIHNDYRRTQPLNHRVVEANFKSLPN- Ailuropoda_melanoleuca NVHWFVLVHHVPLSSA--QIWKLENSIVDHENKTLHNGYRRTQPLNNRVVETNLMSLPN- Myotis_lucifugus NVRWFLLADLVPLSKA--QITKLENSLVDHQDEAIHNVYRKAQPLNDRVVEANFEYHSDY Homo_sapiens NVHWFVLADFVKLSRT--QVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEY- Tursiops_truncatus NVHWFVLADTVKLSRT--QVWKLENSLLNHQNKTIHNDYRGTQTLNNRVVEANFMSQLN- Bos_taurus NVHWFVVADTVKLSKT--QIEKLENSLLNHQNETIQNNYRSTQPLNHRVVEANFVSHPHQ Erinaceus_europaeus DISWFLLADAVLISIT--QARNLESTLQDHSNKTLQNNYRTTQPLHNRVVESNFKILFNQ Rattus_norvegicus NVKWFVFQDSATISKA--QAERIENAVMDHHNQTIRNGYRRTQPLHNRVVEANFPYSPD- Oryctolagus_cuniculus NVLWFVLANSAFLSRA--QVWKMENSLLNHLNETLQNGYRSTQPLNQRVVEANFLHYPTQ Gorilla_gorilla NVHWFVLADFVKLSRM--QVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQGA- Nomascus_leucogenys NVHWFVLADFVKLSRT--QVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEY- Ornithorhynchus_anatinus SVIWTIFDAPITVSLA--QIMKLENSLLDHDNHTIHNDYRETQPLNSRVVESSFQVQTIL Spermophilus_tridecemlineatus NVHWFVLADSVKLSRS--QVWKLENSLLNFRNETLHNDYRKTQPLHRRVVEANFQYFPNQ Canis_familiaris NVHWFVLVHHVRLSSI--QTWKLENSILDHQNKTLHSDYRRIQPLNGRVVETNFVNLPS- Otolemur_garnettii NVHWFVMADYVKLSKE--QILKLESSLLDHRNKTIRNDYRRTQPLNDRVVEANFLHLPN- Cavia_porcellus NVRWFVLQDSVKLSRA--QVWKIENSLLTHDNKTLHNGYRSVQPLHDRVVEASF------ Pongo_abelii NVHWFLLADFVKLSRT--QVWKLENSLLDHRNKALHKDYRRTQPLNHRVVESNFPSQGK- Equus_caballus NVQWFLLADPVKLSKS--QVLKLENSLLDSQNKTLNNGYRSTQHLNGRVVETNFIYHPNQ Loxodonta_africana NVLWFVLAEPVRLSSA--QVWKLENSLFDHQNEMLHNDYRRTQPLNNRVVEANFKYFPN- Mus_musculus NVQWFVLRDKVTLSKA--QVVTIENSVMDHNNNTIQNGYRSTQPNNHRVVEANFLNVQD- .: * :. : * ::.:: :. : . ** * * *::.: Taeniopygia_guttata A-Q----CHPEEFTLRLDQIQMQLQDMKTELLNG-LSH-TGTKSSTFPAFYFPVENIESF Takifugu_rubripes GTF----CRQDEIESKLLKIEGLITSLGKYLYA-------EHTGLFPLVLNFQDNNDGGY Gasterosteus_aculeatus GTF----CRQDEIESRLLNIEGLITSLGKHIHS-------EPRARFPLVLDFQEKNAGSY Tetraodon_nigroviridis GTF----CRQDEIESKLLKIEGLITSLGKQLYA-------ERTGLFPLVLNFQHSNDITY Latimeria_chalumnae G-N-----YQEEINIKLEKIEGLVQDLKHMLPNA-TGTVLTINSVSFPAFKFLQETTLSF Danio_rerio GGM----CRQEEIEAKLKRIESLILSLDKKAVQ-------GKQPISPLVLYFPQKNVESF Meleagris_gallopavo E-Q----CQPEELSLKLEQIQTQLRDMKKEFLNG-VSH-TGITSSTFPAFYFPMENIESF Oryzias_latipes GSF----CLQDVIESRLEKIEGLITSLGKNLYS-------DHSDLFPLVLGFPERNYGSY Gallus_gallus E-Q----CQPEELSHKLEQIQTQLQDMKKEFLNG-VSH-TGITCSTFPAFYFPMENIESF Gadus_morhua GTF----CRQDEIESKLLRIENIITSLGKHIHSSEL---LEPQAFSSLVLHFPERNAGSY Xenopus_tropicalis D-----SCQL-EISNKLRLIATELEDIKKRADSSKSSRMLMSGSVSYPSFYFSEDHPGAR Ochotona_princeps ------------------------------------------------------------ Macaca_mulatta --G-----HW-HHGRKQNP-RVKLTSTRHPLAPGSLEA---------------------- Pan_troglodytes --T-----LGSEFQFYLRKIEE-LDYLRRALN---------------------------- Echinops_telfairi RNH-----RLLRTIFKWHPLG-----------SGSPQAQ--------------------- Sus_scrofa --P------RSELHFYLNNIDNNLEYLRRVIEQKKAKGKG--PW---------------- Ailuropoda_melanoleuca --------LLPEFQLYINKLDSKLEYLRRLIEKKNVKEKRYRRK----A----------- Myotis_lucifugus QHA-----LGSELQSYLRKIDSKLDDLLRSEK---------------------------- Homo_sapiens --T-----LGSEFQFYLHKIEEILDYLRRALN---------------------------- Tursiops_truncatus --Q--------------------------------------------------------- Bos_taurus EYT-----LGSKLHFYLNNIDQNLEYLRRFIEQKITKRKKEKYW----P----------- Erinaceus_europaeus RKG-----YL---HMRNNPR-VEQSSTCTSLDFGSLQF---------------------- Rattus_norvegicus --------EVSKNHFYMHEKISHGLKLKKI----KKKRNHSH------------------ Oryctolagus_cuniculus SYV-----SLPEFQSHLSSINRKLEFLRRSII---------------------------- Gorilla_gorilla --R-----ATGHRRRSQNP-GVQPTSTRHPLALGSLEA---------------------- Nomascus_leucogenys --T-----LGSEFQFYLRKIEEILEYLRRALN---------------------------- Ornithorhynchus_anatinus GIYKILTYYPENIKRAKEKVSLS------------SQHSPGSQN---------------- Spermophilus_tridecemlineatus LY--------SRLHRWLSTLVQSLIPKKKKKKKKKKERKKG------------------- Canis_familiaris --------QGSEFQFYVNKLNNKLEYLRRLLEKTKVEKKPHIHQ----A----------- Otolemur_garnettii --Q-----ECAQLQSYLSKIDKDLQSIKKCNKKKKRNRHP--PS----EM---------- Cavia_porcellus ------------------------------------------------------------ Pongo_abelii --G-----HG-HRGRSQNP-RVQPTSTRHPLALGSLEA---------------------- Equus_caballus QSV-----LGSELQFHLTRIDNNLEYFRRLIEQKQVKRK--------------------- Loxodonta_africana --------HYTEFKYYLRQILDVVTDLKGSTEKKKPKRKSDD------------------ Mus_musculus --------MYSSYHLYLKNMQKEILQPKKQ----KKTKKNRHFW----SRK--------- Taeniopygia_guttata VEVHPLRAVSLQAFTLCFWSRAQPVGSQTVLSYSTGERDRELAVTV-----GSELGLWVG Takifugu_rubripes ALAHVSHPIYLNAFTICMHVLSKPEEINTVLSYSSSEHDNEITISITEDMNAREVGLWIG Gasterosteus_aculeatus ALARLSHPMELNSFTVCMHVLPQLEGVHTVVSYASNGNDNELMISIAEDGDGKEVGLWIG Tetraodon_nigroviridis ALAHVSHPD-MNAFTVCLHVLPQDQGSQTVLSYTSSEHENEVAISISADGDSREVGLWIG Latimeria_chalumnae VEVTPLWTMELNSLTSCMWISTQNEGTKAVFSYAMFETDNELVITV-----GSDVGLWIG Danio_rerio AVVNLTHPMELKSFTACMNVQIPPIRDLTVLSYST-SHDNELMISL-----GSEVGLWIG Meleagris_gallopavo VEVRPSHEMSLQAFTLCFWTQAQHVGTQTVLSYSTRERDNELVMTT-----GTDVGLWIG Oryzias_latipes ALARLNHPMDLDSFTVCMHVLPQGPGVHTVISYSSDGNDNELTVSISKDAESGEIGLWIG Gallus_gallus VEVRPRHEMSLQAFTLCFWTQAQHVGTQTVLSYSTRERDNELVMTT-----GTEVGLWIG Gadus_morhua ALARLLHPMDLHAFTACMHVRPQPGTVHTVMSYSSAGVDNELVINV-----GYEVGLWIG Xenopus_tropicalis VEVRPAGSLKMTQFSICVWVRTRNRGSQTVFAYSTSSEDKELVLSV-----GYDIGLWIG Ochotona_princeps ------------------------------------------------------------ Macaca_mulatta ------------------------------------------------------------ Pan_troglodytes ------------------------------------------------------------ Echinops_telfairi ------------------------------------------------------------ Sus_scrofa ------------------------------------------------------------ Ailuropoda_melanoleuca ------------------------------------------------------------ Myotis_lucifugus ------------------------------------------------------------ Homo_sapiens ------------------------------------------------------------ Tursiops_truncatus ------------------------------------------------------------ Bos_taurus ------------------------------------------------------------ Erinaceus_europaeus ------------------------------------------------------------ Rattus_norvegicus ------------------------------------------------------------ Oryctolagus_cuniculus ------------------------------------------------------------ Gorilla_gorilla ------------------------------------------------------------ Nomascus_leucogenys ------------------------------------------------------------ Ornithorhynchus_anatinus ------------------------------------------------------------ Spermophilus_tridecemlineatus ------------------------------------------------------------ Canis_familiaris ------------------------------------------------------------ Otolemur_garnettii ------------------------------------------------------------ Cavia_porcellus ------------------------------------------------------------ Pongo_abelii ------------------------------------------------------------ Equus_caballus ------------------------------------------------------------ Loxodonta_africana ------------------------------------------------------------ Mus_musculus ------------------------------------------------------------ Taeniopygia_guttata GHFLSFPLQQEAQGWLHHCVTWASPEGRASLWLNGAAGQAQSVQKGYVSRAGGTLLLGKA Takifugu_rubripes NAFVNLPHSFRAHDWTNYCVTWSSDLGAAELWINGMVGEQRYLKSGYSVSLSGVFILGRD Gasterosteus_aculeatus NEFVNLPHNFKSFDWANYCITWSSQTGGVDLWINGMVGEQRYLKNGYTISPGGVFIVGKD Tetraodon_nigroviridis NEFVNLPHSFKAHVWTNYCVTWSSQTGGAELWINGMVGEQRHLKRGYSVSLSGVFILGRD Latimeria_chalumnae GYFVSFPLHHRTEDWVYYCVTWTSNTGLAELWINGIVGKGKLIKKGYTIKPGGTLVLGND Danio_rerio DEFVNLSFDLPSSDWTNYCLTWASHNGGAELWVNGVVGKERYIRTGYIIPAGGRLILGKD Meleagris_gallopavo GHFVSFPLYRKAQDWLHYCMAWASQSGIASLWLNGAAGDAKSIQKGYVSQAGGKLVLGKD Oryzias_latipes NEFVNMPHTFRSQDWTNYCITWSSHTGGADIWVNGMLGEQRHLRSGYTIHPGGEFILGKD Gallus_gallus GHFVSFPLYHKARDWLHYCMAWASQSGIANLWLNGAAGDAKSIQRGYVSQAGGMLVLGKD Gadus_morhua NEFVNLPHGFQSPDWANYCVTWSSHSGAAELWINGMGEEQQFLRSGYSISTGGVFVLGKD Xenopus_tropicalis GKFISFNIHHTSEDWVHYCVSWDSPSGAAKLWVSGLPGKEKTLHHGYEIQDKGMVLLGKD Ochotona_princeps ------------------------------------------------------------ Macaca_mulatta ------------------------------------------------------------ Pan_troglodytes ------------------------------------------------------------ Echinops_telfairi ------------------------------------------------------------ Sus_scrofa ------------------------------------------------------------ Ailuropoda_melanoleuca ------------------------------------------------------------ Myotis_lucifugus ------------------------------------------------------------ Homo_sapiens ------------------------------------------------------------ Tursiops_truncatus ------------------------------------------------------------ Bos_taurus ------------------------------------------------------------ Erinaceus_europaeus ------------------------------------------------------------ Rattus_norvegicus ------------------------------------------------------------ Oryctolagus_cuniculus ------------------------------------------------------------ Gorilla_gorilla ------------------------------------------------------------ Nomascus_leucogenys ------------------------------------------------------------ Ornithorhynchus_anatinus ------------------------------------------------------------ Spermophilus_tridecemlineatus ------------------------------------------------------------ Canis_familiaris ------------------------------------------------------------ Otolemur_garnettii ------------------------------------------------------------ Cavia_porcellus ------------------------------------------------------------ Pongo_abelii ------------------------------------------------------------ Equus_caballus ------------------------------------------------------------ Loxodonta_africana ------------------------------------------------------------ Mus_musculus ------------------------------------------------------------ Taeniopygia_guttata RDALLGTF-SNGFGGWLSRVNLWSRVLSAAELRALALCRA-GQPTGDVIAWGQTPMALLG Takifugu_rubripes QDGVLGISNSNAFVGKMTDVNMWDYRLSTADIRDQMSCEGNSTVVGNVISWGTTRLSLYG Gasterosteus_aculeatus QDGLLGITNADAFVGKMTDVNVWDYVLSTADIRDQLSCERNSTVVGNVFSWGTTKLSMFG Tetraodon_nigroviridis QDGLLGISNSNAFVGKMTDVNVWDYILSTADIRDQMSCERNSTVVGNVLSWGTTRLGLYG Latimeria_chalumnae RNDVMGNY-SHGFTGEISHFNVWNYVLSTSEIRRLTQCKT--EMKGNVVGWGTSAMAVFG Danio_rerio QDGFLGISVNDAFVGHMSDVNIWDYVLTEGEIVEQMSCDN-GKVKGNVLSWGVTQLSLYG Meleagris_gallopavo RDTLLGTF-SNGFAGWMTHVNLWSQVLSPADIRALAQCKA-GKLKGDVIAWGETPVTLFG Oryzias_latipes QDGVLGLSDADAFVGKMTDVNVWNYVLSTAEIRTQMSCGRNTSTVGNVFSWGSTKLSIYG Gallus_gallus RDTLLGTF-SNGFVGWMTHVNLWSQVLSPADVRALAQCKA-GNLKGDIIAWGETPMTLFG Gadus_morhua QDGFLGISNTDAFLGRMTDVNVWDYVLSKAEVREQLSCERNATAAGNVFSWGATPLSLYG Xenopus_tropicalis PDDPLGIF-SSAYVGWISQLHLWNYLLEPEHIKSLSQCNM-PVARGNVLAWGETPMAISG Ochotona_princeps ------------------------------------------------------------ Macaca_mulatta ------------------------------------------------------------ Pan_troglodytes ------------------------------------------------------------ Echinops_telfairi ------------------------------------------------------------ Sus_scrofa ------------------------------------------------------------ Ailuropoda_melanoleuca ------------------------------------------------------------ Myotis_lucifugus ------------------------------------------------------------ Homo_sapiens ------------------------------------------------------------ Tursiops_truncatus ------------------------------------------------------------ Bos_taurus ------------------------------------------------------------ Erinaceus_europaeus ------------------------------------------------------------ Rattus_norvegicus ------------------------------------------------------------ Oryctolagus_cuniculus ------------------------------------------------------------ Gorilla_gorilla ------------------------------------------------------------ Nomascus_leucogenys ------------------------------------------------------------ Ornithorhynchus_anatinus ------------------------------------------------------------ Spermophilus_tridecemlineatus ------------------------------------------------------------ Canis_familiaris ------------------------------------------------------------ Otolemur_garnettii ------------------------------------------------------------ Cavia_porcellus ------------------------------------------------------------ Pongo_abelii ------------------------------------------------------------ Equus_caballus ------------------------------------------------------------ Loxodonta_africana ------------------------------------------------------------ Mus_musculus ------------------------------------------------------------ Taeniopygia_guttata GVLLQPDTSC------------ Takifugu_rubripes GVELDGQYRCS----------- Gasterosteus_aculeatus GVQLDSQYRC------------ Tetraodon_nigroviridis GVELDGQYRCS----------- Latimeria_chalumnae GVILKIDSSC------------ Danio_rerio GVQLQGEQVCHRDNNNNRETEK Meleagris_gallopavo GVVLEADTSC------------ Oryzias_latipes GVQLDSQYRC------------ Gallus_gallus GVVLKADTSC------------ Gadus_morhua GVEIDN---------------- Xenopus_tropicalis GVILEPDNSC------------ Ochotona_princeps ---------------------- Macaca_mulatta ---------------------- Pan_troglodytes ---------------------- Echinops_telfairi ---------------------- Sus_scrofa ---------------------- Ailuropoda_melanoleuca ---------------------- Myotis_lucifugus ---------------------- Homo_sapiens ---------------------- Tursiops_truncatus ---------------------- Bos_taurus ---------------------- Erinaceus_europaeus ---------------------- Rattus_norvegicus ---------------------- Oryctolagus_cuniculus ---------------------- Gorilla_gorilla ---------------------- Nomascus_leucogenys ---------------------- Ornithorhynchus_anatinus ---------------------- Spermophilus_tridecemlineatus ---------------------- Canis_familiaris ---------------------- Otolemur_garnettii ---------------------- Cavia_porcellus ---------------------- Pongo_abelii ---------------------- Equus_caballus ---------------------- Loxodonta_africana ---------------------- Mus_musculus ----------------------