; Name Sheet1 ; Species and nomenclature Homo sapiens, HGNC symbols ; Motif collection 10K (9713 PWMs) ; Track collection 1120 ChIP-seq tracks (ENCODE raw signals) ; Minimum NEScore 5.0 ; Rank threshold for visualization 5000 ; ROC threshold for AUC calculation (%) 0.03 ; Minimum identity between orthologous genes 0.05 ; Maximum false discovery rate (FDR) on motif similarity 0.001 ; Motif rankings database 20kb centered around TSS (7 species) ; Track rankings database 20kb centered around TSS (ChIP-seq-derived) ; Number of valid nodes 12 ; iRegulon version iRegulon v1.3 (build: 2015-02-12) # Rank Motif id AUC NES ClusterCode Transcription factor Target genes 1 transfac_public-M00151 0.258445 7.11396 M1 SRF,STAT1,DBP,MEF2D,MEF2C,MEF2A,MEF2BNB-MEF2B,MEF2B EGR1,RAB10,C14orf119,PIK3CG 2 taipale-WRCGTAACCACGYN-GMEB2-DBD 0.240807 6.5946 M2 GMEB2 EGR1,RAB10,NAMPT 3 transfac_pro-M01001 0.23154 6.32171 M1 DEAF1,ELK1 C14orf119,QSER1,EGR1 4 yetfasco-73 0.228102 6.22048 M2 DBP,ATF2,TEF,HLF EGR1,MRPL35,NAMPT 5 yetfasco-2122 0.226308 6.16766 M1 EGR1,C14orf119,QSER1 6 transfac_pro-M01510 0.220927 6.00921 M1 SRF,MEF2A,MEF2C,MEF2D,MEF2BNB-MEF2B,MEF2B PIK3CG,RAB10,C14orf119 7 yetfasco-831 0.220927 6.00921 M1 SRF,MEF2A,MEF2D,MEF2C,MEF2BNB-MEF2B,MEF2B PIK3CG,RAB10,C14orf119 8 homer-M00042 0.202093 5.45464 M1 ELK1,ETV1,ETV4,ETV2,ETV3,ELK4,FLI1,ETS1,ETV5,GABPA,ERF,ERG,ELK3,FEV,ELF4,ELF2,ETS2,ELF3,ELF1,GABPB1,ELF5,EHF,ETV7,ETV6 PIK3CG,EGR1,C14orf119 9 homer-M01837 0.199701 5.38421 M1 EGR1,ZNF420,RAB10 10 swissregulon-NKX3-2.p2 0.196413 5.28738 M3 NKX3-2 MRPL35,PIK3CG,QSER1 11 jaspar-CN0171.1 0.188042 5.04091 M4 QSER1,CHM 12 hdpi-MORG1 0.187593 5.0277 M4 WDR83 EGR1,PIK3CG # Rank Track id AUC NES ClusterCode Transcription factor Target genes 1 GSM1208655_batch1_chrom1_LoVo_MZF1_PassedQC_peaks_hg19 0.268909 5.64121 T1 MZF1 RAB10,EGR1,MRPL35