,2 modules of PPI network,,,,,,,,,module 1,,,,,,,,,,,,,,,
module 1,,,,,,,,,,GOID,GOTerm,Ontology Source,Term PValue,Term PValue Corrected with Bonferroni step down,Group PValue,Group PValue Corrected with Bonferroni step down,GOLevels,GOGroups,% Associated Genes,Nr. Genes,Associated Genes Found,,,,
SUID,MCODE_Cluster,MCODE_Node_Status,MCODE_Score,name,selected,shared name,,,,R-HSA:983189,Kinesins,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group0,5.08,3.00,"[KIF20A, KIF4A, RACGAP1]",,,,
127,Cluster 1,Clustered,32,NCAPG,FALSE,NCAPG,,,,R-HSA:141424,Amplification of signal from the kinetochores,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,11.46,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
125,Cluster 1,Clustered,32,KIF14,FALSE,KIF14,,,,R-HSA:141444,Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,11.46,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
124,Cluster 1,Clustered,32,PRC1,FALSE,PRC1,,,,R-HSA:195258,RHO GTPase Effectors,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,4.09,13.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, KIF14, MAD2L1, NDC80, NUF2, PRC1, ZWINT]",,,,
120,Cluster 1,Clustered,32,RRM2,FALSE,RRM2,,,,R-HSA:2467813,Separation of Sister Chromatids,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,5.79,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
118,Cluster 1,Clustered,32,KIF20A,FALSE,KIF20A,,,,R-HSA:2500257,Resolution of Sister Chromatid Cohesion,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,11.11,14.00,"[BIRC5, BUB1, BUB1B, CCNB1, CCNB2, CDC20, CDK1, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
112,Cluster 1,Clustered,32,ECT2,FALSE,ECT2,,,,R-HSA:2555396,Mitotic Metaphase and Anaphase,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,5.45,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
111,Cluster 1,Clustered,32,RACGAP1,FALSE,RACGAP1,,,,R-HSA:5663220,RHO GTPases Activate Formins,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,7.86,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
748,Cluster 1,Clustered,27.93563218,FAM83D,FALSE,FAM83D,,,,R-HSA:68877,Mitotic Prometaphase,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,8.00,16.00,"[BIRC5, BUB1, BUB1B, CCNB1, CCNB2, CDC20, CDK1, CENPF, CENPK, CENPU, MAD2L1, NCAPG, NDC80, NEK2, NUF2, ZWINT]",,,,
108,Cluster 1,Clustered,32,ZWINT,FALSE,ZWINT,,,,R-HSA:68882,Mitotic Anaphase,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,5.47,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
745,Cluster 1,Clustered,31,HELLS,FALSE,HELLS,,,,R-HSA:68886,M Phase,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,4.30,17.00,"[BIRC5, BUB1, BUB1B, CCNB1, CCNB2, CDC20, CDK1, CENPF, CENPK, CENPU, KIF20A, MAD2L1, NCAPG, NDC80, NEK2, NUF2, ZWINT]",,,,
105,Cluster 1,Clustered,32,NEK2,FALSE,NEK2,,,,R-HSA:69618,Mitotic Spindle Checkpoint,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,9.82,11.00,"[BIRC5, BUB1, BUB1B, CDC20, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
680,Cluster 1,Clustered,30,UBE2T,FALSE,UBE2T,,,,R-HSA:69620,Cell Cycle Checkpoints,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,4.78,14.00,"[BIRC5, BUB1, BUB1B, CCNB1, CCNB2, CDC20, CDK1, CENPF, CENPK, CENPU, MAD2L1, NDC80, NUF2, ZWINT]",,,,
357,Cluster 1,Clustered,30,EZH2,FALSE,EZH2,,,,KEGG:04110,Cell cycle,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.45,8.00,"[BUB1, BUB1B, CCNB1, CCNB2, CDC20, CDK1, MAD2L1, TTK]",,,,
547,Cluster 1,Seed,32,RAD51AP1,FALSE,RAD51AP1,,,,KEGG:04114,Oocyte meiosis,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,4.84,6.00,"[BUB1, CCNB1, CCNB2, CDC20, CDK1, MAD2L1]",,,,
163,Cluster 1,Clustered,32,HMMR,FALSE,HMMR,,,,KEGG:04115,p53 signaling pathway,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,5.56,4.00,"[CCNB1, CCNB2, CDK1, RRM2]",,,,
99,Cluster 1,Clustered,32,BIRC5,FALSE,BIRC5,,,,KEGG:04914,Progesterone-mediated oocyte maturation,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,5.05,5.00,"[BUB1, CCNB1, CCNB2, CDK1, MAD2L1]",,,,
226,Cluster 1,Clustered,32,NUSAP1,FALSE,NUSAP1,,,,R-HSA:141405,Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,15.00,3.00,"[BUB1B, CDC20, MAD2L1]",,,,
96,Cluster 1,Clustered,32,TTK,FALSE,TTK,,,,R-HSA:141430,Inactivation of APC/C via direct inhibition of the APC/C complex,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,15.00,3.00,"[BUB1B, CDC20, MAD2L1]",,,,
476,Cluster 1,Clustered,32,DTL,FALSE,DTL,,,,R-HSA:156711,Polo-like kinase mediated events,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,18.75,3.00,"[CCNB1, CCNB2, CENPF]",,,,
156,Cluster 1,Clustered,32,KIF4A,FALSE,KIF4A,,,,R-HSA:162658,Golgi Cisternae Pericentriolar Stack Reorganization,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,21.43,3.00,"[CCNB1, CCNB2, CDK1]",,,,
214,Cluster 1,Clustered,32,CDKN3,FALSE,CDKN3,,,,R-HSA:174048,APC/C:Cdc20 mediated degradation of Cyclin B,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,13.04,3.00,"[CCNB1, CDC20, CDK1]",,,,
86,Cluster 1,Clustered,32,BUB1B,FALSE,BUB1B,,,,R-HSA:174143,APC/C-mediated degradation of cell cycle proteins,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.98,6.00,"[BUB1B, CCNB1, CDC20, CDK1, MAD2L1, NEK2]",,,,
84,Cluster 1,Clustered,32,MAD2L1,FALSE,MAD2L1,,,,R-HSA:174184,Cdc20:Phospho-APC/C mediated degradation of Cyclin A,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,5.56,4.00,"[BUB1B, CDC20, CDK1, MAD2L1]",,,,
339,Cluster 1,Clustered,32,ANLN,FALSE,ANLN,,,,R-HSA:176408,Regulation of APC/C activators between G1/S and early anaphase,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.25,5.00,"[BUB1B, CCNB1, CDC20, CDK1, MAD2L1]",,,,
82,Cluster 1,Clustered,32,BUB1,FALSE,BUB1,,,,R-HSA:176409,APC/C:Cdc20 mediated degradation of mitotic proteins,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,8.00,6.00,"[BUB1B, CCNB1, CDC20, CDK1, MAD2L1, NEK2]",,,,
785,Cluster 1,Clustered,26,E2F8,FALSE,E2F8,,,,R-HSA:176417,Phosphorylation of Emi1,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,50.00,3.00,"[CCNB1, CDC20, CDK1]",,,,
273,Cluster 1,Clustered,32,DLGAP5,FALSE,DLGAP5,,,,R-HSA:176814,Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,7.89,6.00,"[BUB1B, CCNB1, CDC20, CDK1, MAD2L1, NEK2]",,,,
145,Cluster 1,Clustered,32,TOP2A,FALSE,TOP2A,,,,R-HSA:179409,APC-Cdc20 mediated degradation of Nek2A,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,16.00,4.00,"[BUB1B, CDC20, MAD2L1, NEK2]",,,,
80,Cluster 1,Clustered,32,NDC80,FALSE,NDC80,,,,R-HSA:179419,APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.85,5.00,"[BUB1B, CDC20, CDK1, MAD2L1, NEK2]",,,,
79,Cluster 1,Clustered,32,NUF2,FALSE,NUF2,,,,R-HSA:2514853,Condensation of Prometaphase Chromosomes,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,36.36,4.00,"[CCNB1, CCNB2, CDK1, NCAPG]",,,,
333,Cluster 1,Clustered,32,ASPM,FALSE,ASPM,,,,R-HSA:2565942,Regulation of PLK1 Activity at G2/M Transition,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,4.55,4.00,"[CCNB1, CCNB2, CDK1, NEK2]",,,,
77,Cluster 1,Clustered,32,CCNB1,FALSE,CCNB1,,,,R-HSA:2980766,Nuclear Envelope Breakdown,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,5.88,3.00,"[CCNB1, CCNB2, CDK1]",,,,
140,Cluster 1,Clustered,27.87126437,CENPK,FALSE,CENPK,,,,R-HSA:2980767,"Activation of NIMA Kinases NEK9, NEK6, NEK7",REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,42.86,3.00,"[CCNB1, CCNB2, CDK1]",,,,
139,Cluster 1,Clustered,32,MLF1IP,FALSE,MLF1IP,,,,R-HSA:3301854,Nuclear Pore Complex (NPC) Disassembly,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,8.82,3.00,"[CCNB1, CCNB2, CDK1]",,,,
75,Cluster 1,Clustered,32,CCNB2,FALSE,CCNB2,,,,R-HSA:453276,Regulation of mitotic cell cycle,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.98,6.00,"[BUB1B, CCNB1, CDC20, CDK1, MAD2L1, NEK2]",,,,
73,Cluster 1,Clustered,32,CDC20,FALSE,CDC20,,,,R-HSA:6791312,TP53 Regulates Transcription of Cell Cycle Genes,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.12,3.00,"[CCNB1, CDK1, E2F8]",,,,
136,Cluster 1,Clustered,32,CENPF,FALSE,CENPF,,,,R-HSA:69273,Cyclin A/B1/B2 associated events during G2/M transition,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,12.00,3.00,"[CCNB1, CCNB2, CDK1]",,,,
72,Cluster 1,Clustered,32,CDK1,FALSE,CDK1,,,,R-HSA:69478,G2/M DNA replication checkpoint,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,60.00,3.00,"[CCNB1, CCNB2, CDK1]",,,,
199,Cluster 1,Clustered,32,PBK,FALSE,PBK,,,,R-HSA:8854518,AURKA Activation by TPX2,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,4.11,3.00,"[CDK1, HMMR, NEK2]",,,,
,,,,,,,,,,,,,,,,,,,,,,,,,
molude 2,,,,,,,,,,,,,,,,,,,,,,,,,
SUID,MCODE_Cluster,MCODE_Node_Status,MCODE_Score,name,selected,shared name,,,,,,,,,,,,,,,,,,,
223,Cluster 2,Clustered,6.611111111,CYP1A2,FALSE,CYP1A2,,,,,,,,,,,,,,,,,,,
350,Cluster 2,Clustered,5.785714286,CYP26A1,FALSE,CYP26A1,,,,,,,,,,,,,,,,,,,
919,Cluster 2,Clustered,5.785714286,ACSL4,FALSE,ACSL4,,,,,,,,,,,,,,,,,,,
279,Cluster 2,Clustered,6.611111111,CYP3A4,FALSE,CYP3A4,,,,,,,,,,,,,,,,,,,
308,Cluster 2,Clustered,6.611111111,CYP2B6,FALSE,CYP2B6,,,,,,,,,,,,,,,,,,,
212,Cluster 2,Clustered,6,HGF,FALSE,HGF,,,,,,,,,,,,,,,,,,,
211,Cluster 2,Clustered,6,SERPINE1,FALSE,SERPINE1,,,,,,,,,,,,,,,,,,,
179,Cluster 2,Clustered,6,EGR1,FALSE,EGR1,,,,,,,,,,,,,,,,,,,
178,Cluster 2,Clustered,6,FOS,FALSE,FOS,,,,,,,,,,,,,,,,,,,
304,Cluster 2,Clustered,6.611111111,CYP4A11,FALSE,CYP4A11,,,,,,,,,,,,,,,,,,,
174,Cluster 2,Seed,7,ESR1,FALSE,ESR1,,,,,,,,,,,,,,,,,,,
173,Cluster 2,Clustered,6,IGF1,FALSE,IGF1,,,,,,,,,,,,,,,,,,,
905,Cluster 2,Clustered,5.785714286,KMO,FALSE,KMO,,,,,,,,,,,,,,,,,,,
290,Cluster 2,Clustered,6.611111111,CYP2A6,FALSE,CYP2A6,,,,,,,,,,,,,,,,,,,
258,Cluster 2,Clustered,5.785714286,CYP2E1,FALSE,CYP2E1,,,,,,,,,,,,,,,,,,,
514,Cluster 2,Clustered,6,SPP1,FALSE,SPP1,,,,,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,,,,,,,,,,,
molude 2,,,,,,,,,,,,,,,,,,,,,,,,,
GOID,GOTerm,Ontology Source,Term PValue,Term PValue Corrected with Bonferroni step down,Group PValue,Group PValue Corrected with Bonferroni step down,GOLevels,GOGroups,% Associated Genes,Nr. Genes,Associated Genes Found,,,,,,,,,,,,,,
KEGG:00830,Retinol metabolism,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group0,8.96,6.00,"[CYP1A2, CYP26A1, CYP2A6, CYP2B6, CYP3A4, CYP4A11]",,,,,,,,,,,,,,
R-HSA:211897,Cytochrome P450 - arranged by substrate type,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,10.61,7.00,"[CYP1A2, CYP26A1, CYP2A6, CYP2B6, CYP2E1, CYP3A4, CYP4A11]",,,,,,,,,,,,,,
R-HSA:211945,Phase I - Functionalization of compounds,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group1,6.54,7.00,"[CYP1A2, CYP26A1, CYP2A6, CYP2B6, CYP2E1, CYP3A4, CYP4A11]",,,,,,,,,,,,,,
KEGG:00590,Arachidonic acid metabolism,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,4.76,3.00,"[CYP2B6, CYP2E1, CYP4A11]",,,,,,,,,,,,,,
KEGG:00980,Metabolism of xenobiotics by cytochrome P450,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.58,5.00,"[CYP1A2, CYP2A6, CYP2B6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
KEGG:00982,Drug metabolism,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,6.94,5.00,"[CYP1A2, CYP2A6, CYP2B6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:211981,Xenobiotics,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,20.83,5.00,"[CYP1A2, CYP2A6, CYP2B6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:211999,CYP2E1 reactions,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group2,27.27,3.00,"[CYP2A6, CYP2B6, CYP2E1]",,,,,,,,,,,,,,
KEGG:00140,Steroid hormone biosynthesis,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,5.08,3.00,"[CYP1A2, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
KEGG:00591,Linoleic acid metabolism,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,10.34,3.00,"[CYP1A2, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
KEGG:00980,Metabolism of xenobiotics by cytochrome P450,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,6.58,5.00,"[CYP1A2, CYP2A6, CYP2B6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
KEGG:00982,Drug metabolism,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,6.94,5.00,"[CYP1A2, CYP2A6, CYP2B6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
KEGG:05204,Chemical carcinogenesis,KEGG_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,4.88,4.00,"[CYP1A2, CYP2A6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:211981,Xenobiotics,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,20.83,5.00,"[CYP1A2, CYP2A6, CYP2B6, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:211999,CYP2E1 reactions,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,27.27,3.00,"[CYP2A6, CYP2B6, CYP2E1]",,,,,,,,,,,,,,
R-HSA:9018677,Biosynthesis of DHA-derived SPMs,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,17.65,3.00,"[CYP1A2, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:9018678,Biosynthesis of specialized proresolving mediators (SPMs),REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,15.79,3.00,"[CYP1A2, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:9018682,Biosynthesis of maresins,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,37.50,3.00,"[CYP1A2, CYP2E1, CYP3A4]",,,,,,,,,,,,,,
R-HSA:9027307,Biosynthesis of maresin-like SPMs,REACTOME_Pathways_04.09.2018,0.00,0.00,0.00,0.00,[-1],Group3,50.00,3.00,"[CYP1A2, CYP2E1, CYP3A4]",,,,,,,,,,,,,,