# Constructed from biom file #OTU ID F06 F08 F17 F21 F26 N01 N02 N19 N20 F02 N10 F19 F03 F01 F07 F10 F12 F13 F20 F22 N04 N05 N06 N08 N11 N12 N13 N18 N21 N22 N17 N14 N23 F09 F14 F25 F27 N03 N15 N09 N07 N16 F28 F18 F15 F04 F05 F11 F16 F23 F24 KEGG_Pathways 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation 175.0 427.0 18.0 376.0 643.0 12.0 37.0 311.0 360.0 495.0 179.0 290.0 316.0 800.0 331.0 626.0 241.0 355.0 141.0 97.0 47.0 41.0 55.0 184.0 3.0 37.0 100.0 483.0 2.0 981.0 99.0 114.0 241.0 306.0 15.0 38.0 77.0 94.0 13.0 37.0 274.0 110.0 116.0 459.0 1978.0 430.0 207.0 157.0 214.0 406.0 181.0 Metabolism; Xenobiotics Biodegradation and Metabolism; 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation ABC transporters 407901.0 623486.0 602420.0 421862.0 393854.0 332808.0 504465.0 523025.0 415831.0 550419.0 440754.0 387059.0 328806.0 448265.0 567652.0 455510.0 370475.0 322475.0 400686.0 390996.0 377549.0 399309.0 375560.0 478932.0 380914.0 430479.0 391663.0 395541.0 480768.0 452759.0 340237.0 445678.0 403169.0 498332.0 306986.0 406956.0 493945.0 382552.0 517696.0 272984.0 531179.0 467549.0 308282.0 341565.0 595971.0 584139.0 444108.0 302997.0 378679.0 298633.0 305550.0 Environmental Information Processing; Membrane Transport; ABC transporters Adherens junction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Communication; Adherens junction Adipocytokine signaling pathway 12838.0 12456.0 11605.0 15095.0 16785.0 15619.0 15199.0 17706.0 15799.0 15651.0 16331.0 15642.0 17064.0 17583.0 13784.0 15776.0 15656.0 14166.0 13595.0 16197.0 13186.0 14045.0 13926.0 16928.0 17094.0 14774.0 16432.0 14614.0 17096.0 19298.0 17936.0 20866.0 16699.0 15307.0 16939.0 16784.0 16589.0 16230.0 14186.0 12870.0 13614.0 15234.0 13653.0 14040.0 18376.0 16706.0 14368.0 13179.0 14895.0 14228.0 13065.0 Organismal Systems; Endocrine System; Adipocytokine signaling pathway African trypanosomiasis 297.0 367.0 240.0 53.0 25.0 370.0 541.0 143.0 61.0 51.0 304.0 151.0 79.0 31.0 10.0 29.0 21.0 19.0 570.0 48.0 81.0 66.0 159.0 3.0 13.0 97.0 41.0 170.0 20.0 307.0 7.0 169.0 29.0 145.0 61.0 1049.0 22.0 81.0 589.0 78.0 88.0 24.0 17.0 16.0 50.0 8.0 1827.0 11.0 17.0 15.0 26.0 Human Diseases; Infectious Diseases; African trypanosomiasis Alanine, aspartate and glutamate metabolism 167632.0 183461.0 205067.0 175923.0 186001.0 176735.0 219115.0 213288.0 185849.0 206162.0 183946.0 173025.0 178503.0 190165.0 193340.0 184419.0 160301.0 160447.0 169742.0 184097.0 162905.0 156288.0 164716.0 203919.0 196025.0 178784.0 184093.0 176832.0 223341.0 188192.0 183567.0 225576.0 191314.0 189817.0 185395.0 196530.0 212842.0 187635.0 166710.0 133904.0 187144.0 206631.0 147497.0 156632.0 198584.0 213757.0 175767.0 150704.0 169063.0 156461.0 152234.0 Metabolism; Amino Acid Metabolism; Alanine, aspartate and glutamate metabolism Aldosterone-regulated sodium reabsorption 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Excretory System; Aldosterone-regulated sodium reabsorption Alzheimer's disease 6396.0 7533.0 7636.0 6429.0 6515.0 6891.0 8210.0 7652.0 6384.0 7807.0 7321.0 6494.0 5760.0 6864.0 7663.0 6194.0 6463.0 5772.0 6948.0 6592.0 6402.0 6890.0 7358.0 7286.0 6469.0 7126.0 6578.0 6644.0 7735.0 6937.0 6147.0 8577.0 6507.0 6968.0 6245.0 7774.0 7899.0 6588.0 8660.0 6629.0 7143.0 7341.0 6747.0 7117.0 7071.0 8070.0 7995.0 5494.0 5906.0 5710.0 7073.0 Human Diseases; Neurodegenerative Diseases; Alzheimer's disease Amino acid metabolism 28083.0 27820.0 40109.0 29415.0 25361.0 28205.0 35419.0 32502.0 26978.0 30899.0 32520.0 27243.0 31192.0 27541.0 27480.0 31305.0 28369.0 26682.0 29642.0 33437.0 29579.0 28423.0 25505.0 33433.0 31754.0 28700.0 32190.0 31941.0 36398.0 32704.0 32118.0 29350.0 30969.0 29473.0 29243.0 34831.0 29672.0 29914.0 38190.0 20044.0 32937.0 31786.0 18170.0 20357.0 26423.0 33336.0 38309.0 25127.0 24962.0 24741.0 20402.0 Unclassified; Metabolism; Amino acid metabolism Amino acid related enzymes 205807.0 242826.0 248427.0 215387.0 214630.0 218151.0 277248.0 256503.0 214403.0 258869.0 233578.0 210729.0 196810.0 225124.0 250104.0 211801.0 209540.0 193248.0 215833.0 216532.0 206827.0 219868.0 224335.0 245891.0 222768.0 228021.0 213910.0 221301.0 256833.0 229196.0 208773.0 268294.0 222798.0 231551.0 205846.0 232641.0 260404.0 217727.0 258392.0 198384.0 244865.0 252937.0 203753.0 214226.0 237972.0 270014.0 218665.0 182545.0 196423.0 186427.0 214655.0 Metabolism; Amino Acid Metabolism; Amino acid related enzymes Amino sugar and nucleotide sugar metabolism 226233.0 239071.0 280425.0 240176.0 231264.0 254078.0 273187.0 282197.0 230125.0 263053.0 232787.0 230285.0 225775.0 225840.0 250748.0 238851.0 212548.0 217364.0 227924.0 241132.0 228053.0 217365.0 224699.0 265667.0 270010.0 246504.0 242345.0 226415.0 306779.0 230138.0 253313.0 277435.0 254258.0 253535.0 263863.0 256621.0 286477.0 254663.0 226406.0 189770.0 264313.0 280540.0 196031.0 200034.0 211022.0 290884.0 245997.0 214054.0 218736.0 213929.0 211203.0 Metabolism; Carbohydrate Metabolism; Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis 152624.0 188265.0 187563.0 162996.0 159617.0 161801.0 206316.0 190736.0 155892.0 199575.0 176573.0 157197.0 137808.0 170539.0 194206.0 153499.0 161107.0 141102.0 163201.0 157428.0 155877.0 174672.0 177527.0 182589.0 158942.0 177263.0 158301.0 162980.0 187831.0 175083.0 145355.0 212266.0 162476.0 174589.0 143868.0 166505.0 194095.0 158655.0 209573.0 156775.0 187209.0 186320.0 157922.0 169326.0 186492.0 211882.0 160483.0 132168.0 141592.0 136020.0 167837.0 Genetic Information Processing; Translation; Aminoacyl-tRNA biosynthesis Aminobenzoate degradation 17782.0 19521.0 19180.0 21809.0 20442.0 15684.0 19351.0 22048.0 18581.0 19863.0 20197.0 20326.0 18999.0 20747.0 16619.0 21321.0 18456.0 18747.0 20365.0 19033.0 17459.0 15434.0 16577.0 19275.0 19442.0 17681.0 20673.0 21944.0 21766.0 23063.0 18961.0 22021.0 19654.0 19350.0 14083.0 21824.0 19301.0 19455.0 17812.0 14664.0 22205.0 21759.0 13476.0 16305.0 29238.0 26586.0 30782.0 17990.0 16499.0 19346.0 16315.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Aminobenzoate degradation Amoebiasis 1106.0 1064.0 1692.0 2100.0 2040.0 897.0 2235.0 2672.0 1566.0 2404.0 2235.0 2037.0 2164.0 2255.0 1497.0 2620.0 1443.0 1611.0 1817.0 2084.0 1277.0 2305.0 2026.0 2367.0 3183.0 2376.0 2096.0 2267.0 2274.0 1776.0 4379.0 2103.0 2834.0 1744.0 825.0 2710.0 2082.0 3043.0 2095.0 892.0 2165.0 2643.0 520.0 621.0 1887.0 2804.0 3554.0 1266.0 2055.0 754.0 623.0 Human Diseases; Infectious Diseases; Amoebiasis Amyotrophic lateral sclerosis (ALS) 2804.0 2226.0 2630.0 1539.0 1645.0 3582.0 1866.0 2239.0 1051.0 1576.0 1680.0 1716.0 1438.0 1487.0 1830.0 2032.0 1211.0 2732.0 2190.0 1955.0 2215.0 749.0 1113.0 990.0 1679.0 1279.0 1439.0 2281.0 1016.0 2039.0 2109.0 1037.0 1590.0 1757.0 3693.0 915.0 1084.0 1209.0 1386.0 898.0 4459.0 1537.0 474.0 890.0 3067.0 2439.0 1944.0 2703.0 1211.0 3162.0 850.0 Human Diseases; Neurodegenerative Diseases; Amyotrophic lateral sclerosis (ALS) Antigen processing and presentation 6229.0 6055.0 7120.0 6413.0 6452.0 7874.0 8023.0 7602.0 6384.0 7480.0 6472.0 6484.0 5467.0 6571.0 6760.0 5598.0 5362.0 5578.0 6351.0 7053.0 5976.0 6032.0 6675.0 6973.0 6712.0 6836.0 6193.0 6578.0 7968.0 6018.0 6003.0 8776.0 7117.0 6844.0 8603.0 7014.0 7699.0 6361.0 5266.0 6247.0 7260.0 6517.0 6714.0 6835.0 6425.0 7865.0 5939.0 5503.0 5102.0 5673.0 6674.0 Organismal Systems; Immune System; Antigen processing and presentation Apoptosis 31.0 28.0 11.0 33.0 31.0 186.0 98.0 87.0 13.0 16.0 109.0 358.0 22.0 29.0 7.0 5.0 21.0 16.0 186.0 125.0 87.0 47.0 313.0 20.0 6.0 191.0 242.0 128.0 7.0 96.0 25.0 145.0 123.0 181.0 12.0 57.0 55.0 218.0 513.0 12.0 70.0 14.0 17.0 38.0 9.0 124.0 3.0 30.0 374.0 79.0 27.0 Cellular Processes; Cell Growth and Death; Apoptosis Arachidonic acid metabolism 2470.0 3203.0 3387.0 2918.0 2566.0 3795.0 3798.0 3205.0 2172.0 3474.0 4080.0 2147.0 3856.0 3359.0 2453.0 3597.0 5499.0 2495.0 3156.0 3049.0 2001.0 6722.0 7119.0 2513.0 3402.0 2002.0 2045.0 4157.0 2063.0 3900.0 2294.0 2292.0 3351.0 2742.0 3933.0 4156.0 2323.0 3169.0 6286.0 10932.0 2472.0 3657.0 10498.0 10835.0 3888.0 2567.0 6439.0 1447.0 3031.0 1441.0 10240.0 Metabolism; Lipid Metabolism; Arachidonic acid metabolism Arginine and proline metabolism 179681.0 206172.0 216776.0 194039.0 193711.0 180857.0 232953.0 235461.0 195591.0 228514.0 200853.0 185773.0 183057.0 201200.0 216777.0 191994.0 166259.0 168581.0 191607.0 195767.0 177876.0 166179.0 172600.0 223336.0 205927.0 198091.0 196160.0 191420.0 240753.0 196876.0 194300.0 246758.0 203560.0 207666.0 187976.0 217950.0 233696.0 199753.0 197755.0 121944.0 216019.0 222000.0 136799.0 146651.0 201016.0 243099.0 201472.0 161780.0 175288.0 161657.0 141271.0 Metabolism; Amino Acid Metabolism; Arginine and proline metabolism Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Cardiovascular Diseases; Arrhythmogenic right ventricular cardiomyopathy (ARVC) Ascorbate and aldarate metabolism 14829.0 17007.0 24476.0 17726.0 12634.0 18338.0 13840.0 17524.0 13085.0 14383.0 13698.0 15884.0 15567.0 13995.0 12161.0 19575.0 15414.0 14903.0 14511.0 16985.0 12428.0 11434.0 12261.0 14180.0 17568.0 13670.0 15919.0 16158.0 18061.0 16965.0 14362.0 19723.0 14932.0 16384.0 17272.0 16593.0 15383.0 14801.0 13866.0 10073.0 18957.0 23614.0 7876.0 10265.0 15849.0 23154.0 20879.0 12300.0 13540.0 12410.0 12152.0 Metabolism; Carbohydrate Metabolism; Ascorbate and aldarate metabolism Atrazine degradation 1202.0 2316.0 897.0 1717.0 1268.0 1312.0 1322.0 2748.0 1316.0 2147.0 2541.0 1823.0 1148.0 2095.0 1086.0 1931.0 2015.0 918.0 3755.0 2482.0 1909.0 2659.0 2138.0 2246.0 967.0 2181.0 2278.0 2048.0 1076.0 3058.0 1258.0 1028.0 1555.0 1946.0 996.0 5860.0 1125.0 1425.0 6584.0 1452.0 4829.0 1295.0 693.0 1340.0 3423.0 3222.0 9551.0 1082.0 757.0 1235.0 944.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Atrazine degradation Bacterial chemotaxis 43497.0 63005.0 62871.0 51305.0 45783.0 35204.0 42989.0 69304.0 42596.0 88234.0 39204.0 40230.0 17956.0 35027.0 91282.0 31752.0 33675.0 25060.0 45794.0 44003.0 52423.0 48150.0 61074.0 63855.0 27080.0 58744.0 44069.0 42803.0 69928.0 25675.0 18841.0 38974.0 58684.0 65428.0 26634.0 26593.0 75714.0 48260.0 59123.0 38474.0 92162.0 50141.0 30320.0 38544.0 54013.0 84488.0 29066.0 32928.0 16177.0 36246.0 43465.0 Cellular Processes; Cell Motility; Bacterial chemotaxis Bacterial invasion of epithelial cells 287.0 272.0 244.0 50.0 5.0 328.0 416.0 94.0 77.0 46.0 182.0 70.0 107.0 64.0 19.0 46.0 23.0 43.0 77.0 29.0 17.0 6.0 10.0 27.0 33.0 5.0 63.0 35.0 77.0 83.0 54.0 12.0 23.0 114.0 113.0 9.0 15.0 10.0 9.0 20.0 72.0 37.0 9.0 2.0 12.0 8.0 151.0 14.0 32.0 3.0 12.0 Human Diseases; Infectious Diseases; Bacterial invasion of epithelial cells Bacterial motility proteins 94218.0 126420.0 106363.0 116386.0 95434.0 79153.0 80371.0 146259.0 85875.0 181317.0 83482.0 88247.0 37036.0 74221.0 189296.0 57726.0 71547.0 50896.0 97646.0 86945.0 105179.0 98974.0 128273.0 128043.0 42781.0 119071.0 88903.0 90819.0 135146.0 56818.0 36931.0 81568.0 118468.0 133358.0 50585.0 52200.0 154936.0 93691.0 127451.0 78348.0 204606.0 95480.0 56436.0 76906.0 117158.0 181145.0 74076.0 68600.0 21773.0 74118.0 87043.0 Cellular Processes; Cell Motility; Bacterial motility proteins Bacterial secretion system 93293.0 104938.0 106747.0 99454.0 90662.0 92710.0 122359.0 106113.0 91725.0 102832.0 100726.0 90300.0 84241.0 99940.0 99774.0 89575.0 83671.0 81607.0 95367.0 88774.0 82379.0 82694.0 84442.0 95715.0 90355.0 86005.0 86452.0 92930.0 95524.0 101778.0 84061.0 120011.0 88357.0 96684.0 83360.0 106748.0 99817.0 87334.0 105972.0 70873.0 92568.0 94946.0 76674.0 83087.0 110461.0 108443.0 120968.0 78748.0 85846.0 81174.0 77505.0 Environmental Information Processing; Membrane Transport; Bacterial secretion system Bacterial toxins 16743.0 17342.0 26525.0 19487.0 20448.0 19641.0 22683.0 23227.0 18744.0 22292.0 19873.0 18106.0 18954.0 20354.0 18619.0 20277.0 16686.0 17139.0 18170.0 19630.0 18181.0 17763.0 17046.0 21827.0 21707.0 21782.0 21025.0 18540.0 25517.0 21850.0 20006.0 26329.0 21121.0 20086.0 19379.0 22009.0 21275.0 22020.0 19746.0 11420.0 20694.0 22425.0 10694.0 12388.0 21880.0 24103.0 22714.0 15882.0 17953.0 15253.0 12854.0 Environmental Information Processing; Signaling Molecules and Interaction; Bacterial toxins Basal transcription factors 156.0 304.0 210.0 30.0 46.0 19.0 44.0 244.0 114.0 156.0 270.0 167.0 155.0 291.0 142.0 53.0 32.0 29.0 117.0 48.0 22.0 42.0 15.0 325.0 43.0 24.0 15.0 119.0 50.0 31.0 522.0 202.0 21.0 205.0 95.0 79.0 344.0 16.0 45.0 90.0 24.0 75.0 830.0 65.0 16.0 50.0 28.0 57.0 294.0 21.0 162.0 Genetic Information Processing; Transcription; Basal transcription factors Base excision repair 59842.0 69328.0 71702.0 63417.0 60835.0 63284.0 76559.0 71479.0 60075.0 71695.0 67092.0 61460.0 56905.0 64285.0 69176.0 60858.0 60041.0 56936.0 64649.0 62351.0 59719.0 62506.0 63017.0 69775.0 65051.0 66786.0 62543.0 63904.0 71752.0 66897.0 62316.0 79824.0 62992.0 67399.0 59350.0 67932.0 72106.0 61359.0 76135.0 53266.0 69176.0 69661.0 54316.0 57974.0 66163.0 81581.0 68495.0 53259.0 54819.0 54603.0 57068.0 Genetic Information Processing; Replication and Repair; Base excision repair Benzoate degradation 25098.0 31977.0 32713.0 29066.0 23250.0 22535.0 36545.0 31786.0 24612.0 30565.0 29353.0 27275.0 23256.0 26954.0 28081.0 26634.0 26167.0 22216.0 27168.0 26447.0 24984.0 26269.0 24850.0 27822.0 25095.0 29468.0 27010.0 27196.0 30465.0 29960.0 23020.0 37368.0 25835.0 29544.0 21390.0 24422.0 30568.0 23673.0 31367.0 17552.0 31134.0 32931.0 18537.0 21340.0 31422.0 41910.0 26370.0 20003.0 20587.0 17429.0 19658.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Benzoate degradation Betalain biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Betalain biosynthesis Bile secretion 0.0 137.0 4.0 0.0 1.0 0.0 1.0 11.0 0.0 2.0 0.0 1.0 0.0 1.0 1.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.0 0.0 3.0 1.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 1.0 Organismal Systems; Digestive System; Bile secretion Biosynthesis and biodegradation of secondary metabolites 9876.0 13062.0 12299.0 8585.0 9110.0 11047.0 10992.0 11936.0 10440.0 10513.0 11481.0 10562.0 10274.0 10578.0 9518.0 11079.0 8001.0 7790.0 10142.0 11240.0 8380.0 7963.0 7196.0 11390.0 11262.0 9805.0 11417.0 9349.0 11176.0 10070.0 10255.0 12191.0 10176.0 11217.0 11368.0 12882.0 11309.0 11040.0 11006.0 3936.0 9797.0 11414.0 6448.0 5424.0 9079.0 11646.0 13604.0 6937.0 10607.0 7230.0 4978.0 Unclassified; Metabolism; Biosynthesis and biodegradation of secondary metabolites Biosynthesis of 12-, 14- and 16-membered macrolides 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Metabolism of Terpenoids and Polyketides; Biosynthesis of 12-, 14- and 16-membered macrolides Biosynthesis of ansamycins 16212.0 19670.0 25555.0 17595.0 17290.0 12973.0 20277.0 22654.0 16499.0 24676.0 18161.0 16450.0 13280.0 18350.0 23366.0 19650.0 14522.0 14210.0 15669.0 15422.0 16976.0 16173.0 16956.0 21154.0 18113.0 18294.0 15620.0 17863.0 23367.0 15925.0 14478.0 23293.0 19249.0 20446.0 10694.0 15268.0 23009.0 20937.0 18608.0 11646.0 21111.0 23877.0 12843.0 13839.0 19666.0 25476.0 16043.0 13416.0 16863.0 13526.0 14552.0 Metabolism; Metabolism of Terpenoids and Polyketides; Biosynthesis of ansamycins Biosynthesis of siderophore group nonribosomal peptides 5009.0 6568.0 4328.0 2916.0 3428.0 5005.0 4851.0 5004.0 3288.0 4265.0 4201.0 3063.0 3605.0 3383.0 5340.0 3182.0 3302.0 3375.0 3641.0 2898.0 3189.0 2838.0 3679.0 3766.0 3494.0 2507.0 1869.0 2877.0 4911.0 2428.0 4071.0 3066.0 3384.0 3894.0 4615.0 4226.0 4787.0 3225.0 2344.0 4545.0 4496.0 3721.0 5509.0 4908.0 2744.0 2960.0 5191.0 3279.0 4065.0 3366.0 4855.0 Metabolism; Metabolism of Terpenoids and Polyketides; Biosynthesis of siderophore group nonribosomal peptides Biosynthesis of type II polyketide backbone 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Metabolism of Terpenoids and Polyketides; Biosynthesis of type II polyketide backbone Biosynthesis of type II polyketide products 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Metabolism of Terpenoids and Polyketides; Biosynthesis of type II polyketide products Biosynthesis of unsaturated fatty acids 15666.0 20417.0 18419.0 14176.0 14095.0 16681.0 22094.0 18328.0 14102.0 17881.0 18168.0 13684.0 13860.0 15625.0 16944.0 16029.0 14314.0 11075.0 18870.0 15135.0 13004.0 16216.0 16058.0 16098.0 15126.0 14560.0 15459.0 13958.0 17893.0 15579.0 16682.0 20199.0 14980.0 17837.0 13729.0 23716.0 16215.0 14073.0 23069.0 14131.0 15444.0 16781.0 14375.0 15264.0 14705.0 20177.0 31925.0 9476.0 12729.0 9833.0 14788.0 Metabolism; Lipid Metabolism; Biosynthesis of unsaturated fatty acids Biosynthesis of vancomycin group antibiotics 8555.0 9747.0 11544.0 10744.0 10855.0 12235.0 13031.0 13116.0 10507.0 12725.0 11363.0 10825.0 11089.0 11289.0 11325.0 11460.0 9506.0 8864.0 9562.0 11383.0 8784.0 10615.0 11917.0 12425.0 12669.0 11019.0 10682.0 10516.0 13113.0 11543.0 12407.0 13386.0 12318.0 11408.0 12765.0 12807.0 12434.0 12922.0 11781.0 10724.0 10887.0 12977.0 10992.0 11565.0 10819.0 12545.0 12206.0 7608.0 10815.0 7658.0 11461.0 Metabolism; Metabolism of Terpenoids and Polyketides; Biosynthesis of vancomycin group antibiotics Biotin metabolism 26028.0 26918.0 30643.0 29597.0 28575.0 27438.0 34770.0 31094.0 25908.0 32743.0 30232.0 25084.0 29252.0 28669.0 29818.0 27194.0 25574.0 28007.0 27099.0 28145.0 26722.0 25104.0 23406.0 31888.0 30519.0 26653.0 25253.0 28790.0 34188.0 30423.0 29316.0 30950.0 29588.0 26822.0 27860.0 30804.0 30702.0 28630.0 32568.0 16809.0 28026.0 31378.0 16741.0 19868.0 31014.0 29473.0 32550.0 26275.0 24198.0 26960.0 19552.0 Metabolism; Metabolism of Cofactors and Vitamins; Biotin metabolism Bisphenol degradation 13577.0 12857.0 17443.0 14504.0 14227.0 15037.0 21805.0 18025.0 13020.0 16564.0 13256.0 13290.0 14468.0 14464.0 15356.0 16629.0 12581.0 14691.0 14590.0 14469.0 13464.0 9866.0 10757.0 16142.0 17201.0 13526.0 14285.0 16113.0 18267.0 15061.0 13626.0 17673.0 15709.0 15809.0 14138.0 15536.0 17570.0 15153.0 11893.0 6520.0 16635.0 19148.0 6016.0 7966.0 16476.0 20601.0 17908.0 12852.0 11727.0 13704.0 8619.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Bisphenol degradation Bladder cancer 280.0 317.0 237.0 41.0 7.0 319.0 393.0 93.0 41.0 39.0 175.0 65.0 72.0 5.0 9.0 26.0 14.0 12.0 72.0 11.0 13.0 3.0 2.0 2.0 1.0 4.0 2.0 569.0 13.0 19.0 6.0 5.0 25.0 111.0 53.0 2.0 9.0 4.0 6.0 16.0 320.0 22.0 7.0 2.0 14.0 1.0 140.0 7.0 2.0 2.0 9.0 Human Diseases; Cancers; Bladder cancer Butanoate metabolism 90048.0 113152.0 110961.0 102580.0 99910.0 83224.0 110441.0 113153.0 96687.0 111727.0 94191.0 92453.0 91533.0 111788.0 106840.0 111282.0 84954.0 84913.0 89734.0 88510.0 77775.0 73952.0 81490.0 97102.0 87984.0 85347.0 87597.0 105563.0 96834.0 117893.0 78709.0 109634.0 93125.0 104961.0 80950.0 93341.0 104438.0 84311.0 85829.0 61447.0 104613.0 111773.0 67229.0 84800.0 158838.0 131332.0 107882.0 73699.0 84432.0 78124.0 75259.0 Metabolism; Carbohydrate Metabolism; Butanoate metabolism Butirosin and neomycin biosynthesis 10273.0 9845.0 11595.0 10315.0 11017.0 14766.0 12129.0 13676.0 11010.0 12401.0 10426.0 11955.0 10077.0 10704.0 10581.0 9470.0 9750.0 9832.0 12608.0 12773.0 11198.0 9239.0 10168.0 13349.0 13016.0 11927.0 13288.0 11633.0 15680.0 10336.0 13650.0 18545.0 12586.0 13178.0 16652.0 13907.0 15477.0 11290.0 10449.0 8516.0 14200.0 13751.0 9520.0 9323.0 7842.0 16680.0 13342.0 9147.0 8710.0 10706.0 10273.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Butirosin and neomycin biosynthesis C5-Branched dibasic acid metabolism 44126.0 53696.0 50616.0 50238.0 43458.0 46420.0 60532.0 53814.0 44418.0 53278.0 44395.0 45363.0 40191.0 44942.0 56302.0 45677.0 40505.0 40733.0 45504.0 46577.0 41115.0 36196.0 40899.0 49501.0 47296.0 44422.0 45062.0 46120.0 56140.0 43950.0 38115.0 58967.0 46204.0 51062.0 45362.0 48329.0 53689.0 44515.0 43090.0 29441.0 53290.0 55366.0 30700.0 34907.0 49522.0 60787.0 46858.0 38807.0 39733.0 37431.0 33914.0 Metabolism; Carbohydrate Metabolism; C5-Branched dibasic acid metabolism CAM ligands 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; CAM ligands Caffeine metabolism 2.0 6.0 0.0 3.0 8.0 42.0 23.0 24.0 1.0 1.0 80.0 42.0 0.0 2.0 0.0 0.0 2.0 1.0 485.0 1.0 2.0 26.0 132.0 0.0 0.0 24.0 2.0 138.0 0.0 0.0 0.0 1.0 1.0 30.0 0.0 928.0 0.0 50.0 567.0 0.0 1.0 0.0 2.0 1.0 0.0 0.0 1682.0 0.0 0.0 4.0 14.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Caffeine metabolism Calcium signaling pathway 2.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 2.0 0.0 48.0 10.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 2.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; Calcium signaling pathway Caprolactam degradation 3503.0 4637.0 4079.0 2480.0 1363.0 3324.0 4221.0 2198.0 1452.0 2126.0 3706.0 1939.0 1628.0 1806.0 1286.0 2110.0 1392.0 1160.0 3331.0 954.0 1182.0 1556.0 1152.0 1279.0 568.0 1019.0 890.0 2404.0 1685.0 2607.0 970.0 580.0 1216.0 2276.0 983.0 4142.0 929.0 683.0 4920.0 782.0 2693.0 1917.0 508.0 857.0 3264.0 2546.0 9313.0 1076.0 1145.0 889.0 1043.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Caprolactam degradation Carbohydrate digestion and absorption 1153.0 1054.0 1048.0 3206.0 979.0 5126.0 2405.0 1720.0 730.0 1435.0 1152.0 1374.0 906.0 1406.0 765.0 496.0 2386.0 1461.0 846.0 1805.0 609.0 1980.0 2286.0 937.0 2357.0 755.0 854.0 2338.0 983.0 2058.0 2283.0 5905.0 1426.0 1676.0 5893.0 927.0 1228.0 879.0 1243.0 4293.0 2027.0 1320.0 3479.0 3610.0 167.0 3103.0 1538.0 1077.0 1067.0 921.0 3638.0 Organismal Systems; Digestive System; Carbohydrate digestion and absorption Carbohydrate metabolism 25568.0 27489.0 37331.0 29072.0 27048.0 35946.0 43001.0 38621.0 25200.0 35931.0 28301.0 25940.0 27939.0 28340.0 32006.0 30904.0 24633.0 26726.0 28012.0 32732.0 25302.0 23286.0 24435.0 33811.0 39884.0 29575.0 26509.0 28994.0 39610.0 28310.0 29853.0 40963.0 35225.0 32299.0 35917.0 30943.0 36821.0 33756.0 25270.0 16175.0 34876.0 39642.0 15955.0 17132.0 25908.0 41487.0 32187.0 22707.0 26778.0 23168.0 18134.0 Unclassified; Metabolism; Carbohydrate metabolism Carbon fixation in photosynthetic organisms 95393.0 109800.0 119105.0 102869.0 98975.0 102560.0 121877.0 120953.0 99462.0 120183.0 103388.0 99202.0 91935.0 103489.0 118123.0 105834.0 95555.0 89149.0 95829.0 101978.0 93189.0 94606.0 101493.0 115068.0 110324.0 102153.0 100970.0 100159.0 126694.0 99802.0 100110.0 132294.0 107564.0 111983.0 96763.0 104952.0 122852.0 108265.0 103073.0 89633.0 109387.0 126842.0 92168.0 96080.0 102048.0 130519.0 101457.0 83317.0 94247.0 84501.0 100372.0 Metabolism; Energy Metabolism; Carbon fixation in photosynthetic organisms Carbon fixation pathways in prokaryotes 147540.0 162858.0 165073.0 166484.0 168845.0 159840.0 182460.0 179455.0 157280.0 176913.0 167993.0 155141.0 158858.0 178126.0 160518.0 172832.0 152356.0 151325.0 154560.0 164556.0 140779.0 149952.0 155572.0 165901.0 164525.0 153072.0 158510.0 167483.0 174163.0 192312.0 155350.0 191858.0 165719.0 164338.0 162603.0 170061.0 170247.0 155059.0 161627.0 141170.0 157846.0 179338.0 141797.0 163270.0 216600.0 190794.0 174472.0 135883.0 140724.0 144979.0 155447.0 Metabolism; Energy Metabolism; Carbon fixation pathways in prokaryotes Cardiac muscle contraction 90.0 60.0 30.0 21.0 15.0 52.0 48.0 39.0 9.0 24.0 48.0 42.0 24.0 39.0 42.0 27.0 6.0 3.0 27.0 18.0 9.0 3.0 0.0 0.0 3.0 15.0 3.0 3.0 3.0 18.0 3.0 7.0 27.0 18.0 15.0 0.0 9.0 6.0 6.0 6.0 28.0 9.0 6.0 4.0 9.0 3.0 48.0 3.0 6.0 0.0 6.0 Organismal Systems; Circulatory System; Cardiac muscle contraction Carotenoid biosynthesis 133.0 741.0 139.0 635.0 178.0 325.0 626.0 627.0 65.0 229.0 367.0 676.0 81.0 888.0 121.0 41.0 428.0 227.0 719.0 206.0 319.0 297.0 277.0 109.0 485.0 207.0 278.0 245.0 92.0 752.0 146.0 2699.0 281.0 363.0 123.0 970.0 100.0 518.0 847.0 164.0 259.0 232.0 71.0 182.0 57.0 1314.0 1741.0 49.0 331.0 84.0 89.0 Metabolism; Metabolism of Terpenoids and Polyketides; Carotenoid biosynthesis Cell cycle 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Growth and Death; Cell cycle Cell cycle - Caulobacter 71778.0 81631.0 87271.0 76195.0 72222.0 73628.0 97663.0 84760.0 73745.0 84000.0 78691.0 71946.0 65747.0 75394.0 81358.0 71614.0 71494.0 66113.0 72091.0 74445.0 71830.0 77247.0 76710.0 80974.0 75387.0 77867.0 74389.0 73288.0 88649.0 77016.0 71372.0 87754.0 73749.0 77757.0 70259.0 77669.0 85442.0 72026.0 87270.0 72862.0 79729.0 81528.0 73034.0 75672.0 78869.0 90486.0 70316.0 65256.0 65460.0 65519.0 76576.0 Cellular Processes; Cell Growth and Death; Cell cycle - Caulobacter Cell cycle - yeast 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Growth and Death; Cell cycle - yeast Cell division 12246.0 13451.0 12833.0 12139.0 14523.0 10970.0 13485.0 14447.0 13320.0 13370.0 12879.0 12536.0 13343.0 14022.0 13973.0 14049.0 10536.0 12985.0 11800.0 13107.0 11607.0 10907.0 12219.0 14155.0 13595.0 12107.0 13507.0 13890.0 14954.0 14570.0 12857.0 14759.0 13335.0 13206.0 11018.0 13632.0 13466.0 13346.0 9333.0 10970.0 12690.0 13568.0 11507.0 13210.0 17482.0 13950.0 11003.0 12068.0 11975.0 13419.0 12766.0 Unclassified; Cellular Processes and Signaling; Cell division Cell motility and secretion 27946.0 32306.0 28933.0 38491.0 30271.0 34866.0 33707.0 33347.0 29188.0 33702.0 31894.0 30239.0 31436.0 32048.0 34613.0 32686.0 29615.0 30653.0 33779.0 32387.0 25181.0 26566.0 28248.0 31442.0 31397.0 27072.0 29450.0 33928.0 29922.0 36005.0 28496.0 30707.0 31264.0 31558.0 34196.0 40133.0 30216.0 29958.0 38867.0 21844.0 32102.0 32698.0 21186.0 25775.0 38593.0 34447.0 53974.0 27827.0 26882.0 28142.0 23383.0 Unclassified; Cellular Processes and Signaling; Cell motility and secretion Cellular antigens 8780.0 6031.0 7260.0 9864.0 11352.0 10770.0 10106.0 11491.0 10023.0 9394.0 10023.0 9087.0 13467.0 10753.0 7280.0 11968.0 11904.0 11021.0 9050.0 11292.0 8940.0 9331.0 10793.0 10086.0 11734.0 8049.0 10303.0 10704.0 11070.0 11981.0 11465.0 10767.0 11348.0 8822.0 11461.0 11870.0 8946.0 11838.0 6469.0 13068.0 9546.0 11184.0 11902.0 13240.0 11103.0 9026.0 10589.0 10054.0 9839.0 11357.0 12895.0 Environmental Information Processing; Signaling Molecules and Interaction; Cellular antigens Chagas disease (American trypanosomiasis) 283.0 366.0 240.0 49.0 20.0 366.0 537.0 136.0 58.0 48.0 284.0 121.0 74.0 24.0 10.0 29.0 17.0 14.0 559.0 38.0 20.0 51.0 147.0 2.0 13.0 66.0 26.0 163.0 19.0 297.0 6.0 165.0 22.0 143.0 56.0 1049.0 17.0 70.0 577.0 24.0 77.0 22.0 15.0 15.0 50.0 3.0 1822.0 9.0 17.0 10.0 24.0 Human Diseases; Infectious Diseases; Chagas disease (American trypanosomiasis) Chaperones and folding catalysts 157665.0 183585.0 181779.0 160184.0 171474.0 170740.0 207928.0 197876.0 163711.0 192043.0 171640.0 158219.0 157346.0 176808.0 194962.0 168062.0 153104.0 151501.0 158041.0 160965.0 149733.0 153469.0 167188.0 184237.0 176826.0 162145.0 156927.0 164649.0 192953.0 174934.0 163961.0 200533.0 173679.0 176546.0 165253.0 179839.0 192618.0 171675.0 163516.0 154090.0 172857.0 185657.0 163045.0 171925.0 190123.0 194935.0 173448.0 140674.0 160952.0 148642.0 170186.0 Genetic Information Processing; Folding, Sorting and Degradation; Chaperones and folding catalysts Chloroalkane and chloroalkene degradation 22283.0 25620.0 31169.0 24607.0 22616.0 23430.0 36905.0 30939.0 19974.0 28246.0 25710.0 22743.0 20488.0 25943.0 23510.0 25123.0 18761.0 20065.0 22133.0 23482.0 23304.0 21941.0 20218.0 24537.0 26154.0 23524.0 23979.0 23284.0 29972.0 27224.0 19623.0 36040.0 25507.0 24823.0 18409.0 23794.0 25061.0 26158.0 26820.0 12368.0 27418.0 28909.0 10135.0 12963.0 29178.0 34043.0 26435.0 18192.0 20301.0 17843.0 13733.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Chloroalkane and chloroalkene degradation Chlorocyclohexane and chlorobenzene degradation 910.0 1933.0 1169.0 905.0 1097.0 932.0 779.0 1354.0 806.0 1164.0 1034.0 1242.0 815.0 1298.0 743.0 1576.0 931.0 927.0 1677.0 829.0 685.0 479.0 838.0 997.0 815.0 622.0 767.0 1133.0 668.0 1651.0 506.0 426.0 928.0 1377.0 502.0 2486.0 773.0 867.0 1513.0 478.0 1897.0 1585.0 451.0 829.0 3121.0 1698.0 4804.0 481.0 669.0 706.0 831.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Chlorocyclohexane and chlorobenzene degradation Cholinergic synapse 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Nervous System; Cholinergic synapse Chromosome 228372.0 273800.0 280686.0 235966.0 238336.0 227893.0 301446.0 280865.0 230814.0 288509.0 250262.0 225315.0 206849.0 250164.0 284718.0 233929.0 222995.0 208137.0 225674.0 223445.0 223422.0 239664.0 247171.0 264132.0 239260.0 241949.0 222904.0 228933.0 275209.0 245006.0 231001.0 297144.0 241776.0 255706.0 214538.0 233945.0 281412.0 236415.0 266467.0 224773.0 258273.0 267243.0 232049.0 246415.0 266456.0 295670.0 218824.0 197836.0 217612.0 203673.0 244515.0 Genetic Information Processing; Replication and Repair; Chromosome Chronic myeloid leukemia 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Cancers; Chronic myeloid leukemia Circadian rhythm - plant 2.0 6.0 0.0 3.0 8.0 42.0 23.0 24.0 1.0 1.0 80.0 42.0 0.0 2.0 0.0 0.0 2.0 1.0 485.0 1.0 2.0 26.0 132.0 0.0 0.0 24.0 2.0 138.0 0.0 0.0 0.0 1.0 1.0 30.0 0.0 928.0 0.0 51.0 568.0 0.0 1.0 0.0 2.0 2.0 0.0 0.0 1682.0 0.0 0.0 4.0 14.0 Organismal Systems; Environmental Adaptation; Circadian rhythm - plant Citrate cycle (TCA cycle) 92044.0 102981.0 94855.0 115868.0 116254.0 107713.0 112888.0 116872.0 104729.0 110791.0 106902.0 104488.0 111729.0 124070.0 100380.0 118730.0 103180.0 102266.0 98856.0 108201.0 84111.0 90187.0 99262.0 104092.0 108280.0 89447.0 105284.0 112364.0 106189.0 137627.0 100793.0 131926.0 108450.0 107957.0 106261.0 115376.0 101897.0 101791.0 93431.0 95596.0 95417.0 112714.0 93374.0 111983.0 158796.0 127350.0 126362.0 87210.0 95596.0 98482.0 103161.0 Metabolism; Carbohydrate Metabolism; Citrate cycle (TCA cycle) Clavulanic acid biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Clavulanic acid biosynthesis Colorectal cancer 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 13.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Human Diseases; Cancers; Colorectal cancer Complement and coagulation cascades 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Immune System; Complement and coagulation cascades Cyanoamino acid metabolism 52593.0 48216.0 54069.0 45962.0 53806.0 66444.0 60475.0 61959.0 47895.0 60341.0 47106.0 55462.0 50652.0 48175.0 52060.0 47097.0 47279.0 61645.0 60298.0 62001.0 57612.0 41157.0 47122.0 60995.0 65968.0 59631.0 55535.0 60302.0 66373.0 54106.0 52023.0 57281.0 65429.0 56492.0 69625.0 51347.0 68735.0 56819.0 42186.0 34604.0 70013.0 62919.0 34376.0 39944.0 54317.0 72492.0 46576.0 55959.0 38538.0 67449.0 41223.0 Metabolism; Metabolism of Other Amino Acids; Cyanoamino acid metabolism Cysteine and methionine metabolism 136388.0 167727.0 175185.0 134853.0 141364.0 134009.0 182484.0 164032.0 140062.0 168503.0 146547.0 134058.0 132657.0 147159.0 168025.0 143128.0 133276.0 125627.0 140025.0 139973.0 132624.0 138133.0 142423.0 158800.0 147401.0 143306.0 141929.0 142539.0 173314.0 145725.0 132859.0 178068.0 146011.0 154180.0 132995.0 148911.0 169797.0 141169.0 154155.0 121965.0 151519.0 167599.0 131827.0 140805.0 151319.0 178654.0 142675.0 112592.0 130306.0 118595.0 138043.0 Metabolism; Amino Acid Metabolism; Cysteine and methionine metabolism Cytochrome P450 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Enzyme Families; Cytochrome P450 Cytokine receptors 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; Cytokine receptors Cytokine-cytokine receptor interaction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; Cytokine-cytokine receptor interaction Cytoskeleton proteins 52407.0 62392.0 72462.0 53642.0 53841.0 46628.0 72104.0 67624.0 54915.0 70618.0 57095.0 52959.0 43886.0 58809.0 67583.0 52675.0 46799.0 44772.0 51649.0 48498.0 52944.0 51768.0 55940.0 64344.0 54967.0 58414.0 49145.0 50603.0 67432.0 50709.0 50925.0 76700.0 55882.0 60725.0 46672.0 52976.0 72317.0 56948.0 58737.0 43901.0 59339.0 64208.0 52081.0 52111.0 55980.0 71767.0 42844.0 44811.0 51256.0 43266.0 50618.0 Cellular Processes; Cell Motility; Cytoskeleton proteins Cytosolic DNA-sensing pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Immune System; Cytosolic DNA-sensing pathway D-Alanine metabolism 14207.0 16525.0 17463.0 14344.0 13523.0 11120.0 18554.0 16846.0 13899.0 16796.0 16237.0 14167.0 12040.0 14536.0 15982.0 13304.0 14030.0 11844.0 14099.0 13179.0 14234.0 15549.0 14519.0 15779.0 13092.0 14937.0 13836.0 13370.0 16044.0 15444.0 13130.0 17456.0 13996.0 14979.0 10352.0 13954.0 16356.0 13762.0 18016.0 14008.0 16688.0 15649.0 14005.0 14590.0 15154.0 17967.0 13019.0 11757.0 13393.0 11689.0 14545.0 Metabolism; Metabolism of Other Amino Acids; D-Alanine metabolism D-Arginine and D-ornithine metabolism 438.0 739.0 218.0 1554.0 204.0 297.0 717.0 677.0 563.0 906.0 952.0 594.0 230.0 535.0 398.0 526.0 800.0 452.0 369.0 372.0 640.0 1284.0 308.0 858.0 209.0 647.0 218.0 256.0 333.0 1057.0 635.0 164.0 386.0 628.0 173.0 218.0 303.0 212.0 2392.0 420.0 1552.0 544.0 173.0 198.0 496.0 1120.0 395.0 779.0 223.0 266.0 183.0 Metabolism; Metabolism of Other Amino Acids; D-Arginine and D-ornithine metabolism D-Glutamine and D-glutamate metabolism 20853.0 24804.0 27722.0 23226.0 22388.0 21480.0 30054.0 27713.0 22205.0 27576.0 25217.0 22560.0 22656.0 24333.0 26423.0 23648.0 23144.0 20507.0 22401.0 23303.0 21191.0 23907.0 23780.0 26111.0 25586.0 24271.0 22099.0 23044.0 27041.0 25230.0 23486.0 29654.0 25132.0 24405.0 22334.0 24497.0 27570.0 24849.0 27224.0 20425.0 23129.0 27992.0 21164.0 22758.0 24983.0 27887.0 23418.0 18246.0 22247.0 18057.0 22040.0 Metabolism; Metabolism of Other Amino Acids; D-Glutamine and D-glutamate metabolism DNA repair and recombination proteins 399956.0 467072.0 496175.0 414803.0 407689.0 417520.0 532917.0 488213.0 396760.0 484291.0 445830.0 402850.0 369358.0 434457.0 473577.0 409453.0 394786.0 371989.0 412036.0 404291.0 394337.0 422590.0 430720.0 451614.0 428937.0 433694.0 396425.0 414731.0 478938.0 443009.0 401724.0 537155.0 422042.0 442323.0 385063.0 431730.0 480071.0 413797.0 478605.0 390236.0 451684.0 470266.0 397283.0 420918.0 465226.0 523432.0 422720.0 350282.0 382409.0 356357.0 416591.0 Genetic Information Processing; Replication and Repair; DNA repair and recombination proteins DNA replication 97259.0 103864.0 119514.0 101704.0 98419.0 107265.0 129281.0 114329.0 93617.0 112389.0 106025.0 95261.0 89454.0 99971.0 109471.0 94870.0 93478.0 91881.0 98095.0 97086.0 98950.0 101133.0 103961.0 105720.0 101826.0 104993.0 96753.0 97327.0 118364.0 103544.0 98869.0 124809.0 100712.0 101899.0 94169.0 101540.0 111967.0 100137.0 112258.0 93813.0 106724.0 109010.0 91487.0 97522.0 101836.0 119044.0 95475.0 90355.0 90562.0 90984.0 98645.0 Genetic Information Processing; Replication and Repair; DNA replication DNA replication proteins 185878.0 201454.0 226291.0 183864.0 188448.0 203270.0 239879.0 219066.0 182913.0 214333.0 197359.0 183622.0 166888.0 192990.0 211599.0 185209.0 172234.0 172306.0 183816.0 183520.0 185623.0 183704.0 195183.0 202462.0 194315.0 194636.0 182858.0 184572.0 223564.0 191680.0 194068.0 233017.0 192928.0 197705.0 184612.0 195211.0 218813.0 191615.0 198111.0 179374.0 201348.0 207662.0 181097.0 190286.0 197927.0 226938.0 179417.0 166935.0 178416.0 171876.0 191235.0 Genetic Information Processing; Replication and Repair; DNA replication proteins Dilated cardiomyopathy (DCM) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Cardiovascular Diseases; Dilated cardiomyopathy (DCM) Dioxin degradation 4454.0 6813.0 7924.0 4786.0 3486.0 4234.0 7087.0 7385.0 3476.0 5246.0 4815.0 4406.0 2546.0 4377.0 6015.0 3995.0 3894.0 3135.0 3599.0 4974.0 4511.0 4704.0 4488.0 4574.0 4842.0 5450.0 5003.0 3234.0 6673.0 5872.0 2693.0 11484.0 4268.0 5918.0 2997.0 3738.0 5082.0 4434.0 5009.0 2769.0 6146.0 4760.0 2095.0 2948.0 5246.0 9701.0 2822.0 2332.0 3931.0 1952.0 2668.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Dioxin degradation Drug metabolism - cytochrome P450 4491.0 5924.0 4667.0 4843.0 4095.0 3314.0 6499.0 6145.0 3249.0 4775.0 4624.0 3459.0 3731.0 5617.0 3810.0 4448.0 2820.0 3748.0 4299.0 3041.0 3311.0 2145.0 2569.0 3411.0 4813.0 2484.0 2496.0 4064.0 3154.0 5000.0 2797.0 8424.0 4039.0 4047.0 1217.0 5055.0 2841.0 5178.0 3494.0 1186.0 4435.0 4330.0 930.0 1670.0 5669.0 5462.0 8429.0 3550.0 4642.0 3624.0 1400.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Drug metabolism - cytochrome P450 Drug metabolism - other enzymes 49621.0 52268.0 61099.0 45978.0 48234.0 54195.0 63146.0 59814.0 49625.0 57059.0 53806.0 50313.0 48356.0 49626.0 53868.0 50636.0 50711.0 47182.0 50722.0 52995.0 52928.0 51037.0 52851.0 56537.0 53642.0 54210.0 52217.0 49474.0 62909.0 50334.0 54404.0 60033.0 52844.0 52941.0 52929.0 52293.0 60154.0 53307.0 57489.0 51363.0 60951.0 59228.0 52657.0 52205.0 47646.0 61883.0 46535.0 45045.0 48599.0 46315.0 53075.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes ECM-receptor interaction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; ECM-receptor interaction Electron transfer carriers 3567.0 3907.0 4934.0 2982.0 2055.0 3283.0 4272.0 3214.0 1923.0 3114.0 3297.0 2512.0 1864.0 3349.0 1984.0 3240.0 2567.0 1606.0 1775.0 2319.0 1828.0 2574.0 1432.0 1726.0 1356.0 1645.0 2556.0 1945.0 1063.0 4490.0 1457.0 3535.0 1904.0 3037.0 1128.0 662.0 1062.0 1677.0 3693.0 1147.0 3350.0 1676.0 869.0 1675.0 5437.0 4258.0 2745.0 1131.0 1144.0 1752.0 1135.0 Unclassified; Cellular Processes and Signaling; Electron transfer carriers Endocrine and other factor-regulated calcium reabsorption 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Excretory System; Endocrine and other factor-regulated calcium reabsorption Endocytosis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Transport and Catabolism; Endocytosis Energy metabolism 136991.0 158746.0 170049.0 129543.0 141327.0 146736.0 165392.0 165745.0 139433.0 158185.0 147231.0 138259.0 132799.0 146505.0 161776.0 146030.0 126970.0 124263.0 135856.0 144771.0 126813.0 126476.0 137942.0 152190.0 151271.0 140308.0 143155.0 141305.0 161872.0 143014.0 143079.0 171695.0 148040.0 154954.0 148274.0 149921.0 166234.0 144648.0 131928.0 118713.0 145915.0 162607.0 129342.0 134945.0 154144.0 170624.0 145094.0 112943.0 133008.0 120173.0 133301.0 Unclassified; Metabolism; Energy metabolism Epithelial cell signaling in Helicobacter pylori infection 12420.0 13527.0 15268.0 13488.0 12264.0 11890.0 16008.0 15254.0 12638.0 14615.0 13544.0 12781.0 11211.0 12494.0 14199.0 11552.0 12375.0 11197.0 12927.0 12761.0 12236.0 12928.0 14215.0 14688.0 13209.0 13773.0 12762.0 12461.0 15696.0 11808.0 11740.0 16715.0 12997.0 13841.0 12158.0 13971.0 15741.0 12882.0 13653.0 13352.0 14570.0 14742.0 13379.0 13775.0 12450.0 16266.0 12235.0 11406.0 10928.0 10955.0 13949.0 Human Diseases; Infectious Diseases; Epithelial cell signaling in Helicobacter pylori infection ErbB signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; ErbB signaling pathway Ether lipid metabolism 164.0 156.0 210.0 236.0 96.0 113.0 76.0 131.0 82.0 150.0 182.0 385.0 121.0 127.0 71.0 319.0 180.0 124.0 152.0 81.0 240.0 121.0 120.0 49.0 72.0 78.0 307.0 57.0 92.0 70.0 82.0 64.0 184.0 99.0 51.0 78.0 127.0 367.0 73.0 68.0 143.0 266.0 88.0 56.0 120.0 166.0 157.0 65.0 547.0 74.0 50.0 Metabolism; Lipid Metabolism; Ether lipid metabolism Ethylbenzene degradation 7014.0 5416.0 7853.0 9171.0 7497.0 6252.0 7710.0 8258.0 6449.0 6900.0 7851.0 8352.0 6576.0 7497.0 4772.0 7149.0 6605.0 7644.0 7375.0 6908.0 7551.0 6576.0 6916.0 6648.0 8521.0 7715.0 8205.0 7170.0 8152.0 8679.0 8238.0 12108.0 8185.0 6969.0 5618.0 6532.0 6898.0 8241.0 5477.0 5909.0 7134.0 7969.0 5146.0 5980.0 8407.0 10748.0 8833.0 7923.0 6112.0 8009.0 6244.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Ethylbenzene degradation Fat digestion and absorption 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Digestive System; Fat digestion and absorption Fatty acid biosynthesis 65898.0 80629.0 84495.0 72336.0 70891.0 71634.0 93716.0 85468.0 67590.0 83938.0 75373.0 63693.0 62206.0 76778.0 80524.0 74411.0 61233.0 60043.0 65523.0 68738.0 61819.0 65403.0 62693.0 76646.0 78252.0 70141.0 66462.0 65210.0 85048.0 78111.0 75722.0 95140.0 74049.0 77455.0 72842.0 75178.0 81742.0 68929.0 73215.0 51895.0 67989.0 83002.0 53788.0 59725.0 83774.0 90939.0 78297.0 53901.0 67373.0 52659.0 58703.0 Metabolism; Lipid Metabolism; Fatty acid biosynthesis Fatty acid elongation in mitochondria 2.0 6.0 0.0 3.0 8.0 42.0 23.0 24.0 1.0 1.0 80.0 42.0 0.0 2.0 0.0 0.0 2.0 1.0 485.0 1.0 2.0 26.0 132.0 0.0 0.0 24.0 2.0 138.0 0.0 0.0 0.0 1.0 1.0 30.0 0.0 928.0 0.0 50.0 567.0 0.0 1.0 0.0 2.0 1.0 0.0 0.0 1682.0 0.0 0.0 4.0 14.0 Metabolism; Lipid Metabolism; Fatty acid elongation in mitochondria Fatty acid metabolism 33840.0 41409.0 40702.0 29751.0 31242.0 31782.0 43066.0 40060.0 31959.0 37885.0 36451.0 31169.0 31048.0 36085.0 36168.0 34734.0 29618.0 26586.0 32565.0 30787.0 28383.0 28860.0 28455.0 35132.0 32416.0 31184.0 30217.0 33854.0 36355.0 36208.0 29895.0 41793.0 32438.0 36166.0 28205.0 35992.0 37153.0 30941.0 35857.0 21595.0 35173.0 38391.0 25518.0 26502.0 41073.0 41594.0 41412.0 23876.0 30392.0 24146.0 25604.0 Metabolism; Lipid Metabolism; Fatty acid metabolism Fc epsilon RI signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Immune System; Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Immune System; Fc gamma R-mediated phagocytosis Flagellar assembly 39804.0 51970.0 42289.0 55850.0 36196.0 34343.0 32872.0 67056.0 37420.0 76461.0 31600.0 37469.0 13628.0 26493.0 82264.0 21132.0 31115.0 19885.0 35748.0 34855.0 43897.0 37572.0 54510.0 55566.0 15765.0 49197.0 33658.0 37301.0 55816.0 19059.0 13259.0 30626.0 49777.0 56606.0 21597.0 13379.0 67579.0 37675.0 45760.0 36851.0 101001.0 39617.0 25139.0 32799.0 49354.0 82686.0 19234.0 31865.0 6809.0 30693.0 38055.0 Cellular Processes; Cell Motility; Flagellar assembly Flavone and flavonol biosynthesis 1279.0 1969.0 1879.0 723.0 785.0 2783.0 1220.0 2021.0 1630.0 1657.0 1023.0 1685.0 1162.0 1215.0 1159.0 979.0 1043.0 1170.0 1259.0 1891.0 596.0 484.0 958.0 1834.0 2195.0 1871.0 984.0 1459.0 1378.0 979.0 1868.0 1205.0 1526.0 1692.0 3895.0 1607.0 2681.0 1212.0 1081.0 806.0 3222.0 1640.0 1663.0 939.0 974.0 2235.0 1617.0 997.0 1783.0 891.0 721.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Flavone and flavonol biosynthesis Flavonoid biosynthesis 337.0 770.0 677.0 768.0 434.0 423.0 698.0 1134.0 187.0 535.0 1067.0 858.0 173.0 972.0 100.0 130.0 790.0 330.0 996.0 407.0 447.0 547.0 558.0 334.0 571.0 742.0 497.0 336.0 370.0 907.0 271.0 2878.0 400.0 459.0 296.0 1059.0 298.0 911.0 955.0 495.0 1443.0 497.0 159.0 285.0 1011.0 2058.0 2420.0 189.0 374.0 225.0 194.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Flavonoid biosynthesis Fluorobenzoate degradation 308.0 789.0 261.0 56.0 29.0 423.0 464.0 188.0 46.0 58.0 356.0 166.0 79.0 107.0 30.0 34.0 19.0 12.0 1065.0 33.0 24.0 58.0 266.0 1.0 9.0 53.0 7.0 279.0 18.0 24.0 10.0 8.0 37.0 186.0 58.0 1861.0 13.0 109.0 1147.0 18.0 53.0 28.0 15.0 4.0 40.0 3.0 3521.0 9.0 5.0 13.0 41.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Fluorobenzoate degradation Focal adhesion 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Communication; Focal adhesion Folate biosynthesis 58131.0 65553.0 61904.0 59277.0 61970.0 62890.0 81883.0 66496.0 58406.0 64288.0 64837.0 56997.0 60320.0 61995.0 61949.0 60946.0 59470.0 58127.0 60722.0 61270.0 56482.0 58978.0 59300.0 64197.0 63939.0 57501.0 60428.0 61626.0 71743.0 64765.0 60163.0 67183.0 60888.0 59655.0 57816.0 69789.0 64558.0 59175.0 67755.0 58926.0 60945.0 71337.0 55655.0 60438.0 67746.0 66260.0 72445.0 53732.0 54799.0 57117.0 63627.0 Metabolism; Metabolism of Cofactors and Vitamins; Folate biosynthesis Fructose and mannose metabolism 150919.0 160717.0 194703.0 164757.0 149045.0 157654.0 187212.0 181664.0 149658.0 173082.0 146099.0 143741.0 144405.0 152146.0 160446.0 171108.0 132329.0 138134.0 139479.0 149778.0 141983.0 129035.0 133526.0 169181.0 177855.0 151667.0 151538.0 138832.0 206996.0 145138.0 156926.0 194791.0 159964.0 168413.0 154716.0 160039.0 181233.0 162903.0 127698.0 109126.0 156181.0 201864.0 111409.0 115784.0 137661.0 197444.0 157408.0 135315.0 141545.0 131418.0 130674.0 Metabolism; Carbohydrate Metabolism; Fructose and mannose metabolism Function unknown 188848.0 240723.0 227579.0 202192.0 183338.0 212908.0 243471.0 235085.0 171212.0 226031.0 198683.0 178965.0 179634.0 190540.0 246163.0 188677.0 172812.0 180621.0 194415.0 192968.0 173064.0 168452.0 177066.0 206008.0 214597.0 185836.0 173264.0 192022.0 218210.0 199624.0 172349.0 231846.0 203317.0 207224.0 195092.0 203389.0 213614.0 197956.0 206520.0 138455.0 226113.0 222641.0 131206.0 151925.0 217752.0 240222.0 243937.0 163065.0 183194.0 164879.0 149905.0 Unclassified; Poorly Characterized; Function unknown G protein-coupled receptors 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; G protein-coupled receptors GTP-binding proteins 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; GTP-binding proteins Galactose metabolism 133104.0 130145.0 178461.0 140238.0 130999.0 163657.0 175275.0 171558.0 132785.0 159468.0 127686.0 130567.0 128330.0 130812.0 146963.0 138106.0 109647.0 129871.0 128429.0 140437.0 127166.0 103920.0 114592.0 160181.0 173427.0 135358.0 124267.0 132805.0 178514.0 125425.0 139655.0 169990.0 157609.0 148814.0 175960.0 142702.0 177168.0 153588.0 106009.0 83591.0 157353.0 176986.0 96011.0 93965.0 122497.0 171818.0 137481.0 127098.0 136305.0 123424.0 102417.0 Metabolism; Carbohydrate Metabolism; Galactose metabolism Gastric acid secretion 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Digestive System; Gastric acid secretion General function prediction only 529575.0 599517.0 659784.0 543333.0 544637.0 578699.0 683176.0 658910.0 537515.0 641157.0 570960.0 533550.0 521706.0 566170.0 609827.0 562386.0 502057.0 495636.0 549170.0 571739.0 516079.0 524361.0 542209.0 613578.0 598982.0 564791.0 549054.0 554451.0 657388.0 562664.0 573712.0 672356.0 584537.0 598050.0 578887.0 600366.0 651544.0 569623.0 580670.0 458672.0 608041.0 645166.0 484293.0 508966.0 589654.0 686881.0 591528.0 459423.0 507757.0 467002.0 504849.0 Unclassified; Poorly Characterized; General function prediction only Geraniol degradation 8488.0 7129.0 7041.0 7315.0 6950.0 10411.0 10187.0 7530.0 6484.0 6474.0 8947.0 7260.0 8557.0 6548.0 4430.0 7241.0 6699.0 7581.0 8519.0 7642.0 6784.0 5967.0 6391.0 6747.0 7365.0 5822.0 7410.0 8147.0 7081.0 8403.0 6582.0 6455.0 7866.0 6935.0 7884.0 10219.0 5996.0 7149.0 8595.0 5598.0 6741.0 7871.0 4657.0 5481.0 6796.0 7177.0 14528.0 7230.0 5702.0 7712.0 6105.0 Metabolism; Metabolism of Terpenoids and Polyketides; Geraniol degradation Germination 3720.0 4622.0 5985.0 2839.0 3277.0 2949.0 4932.0 5159.0 3919.0 5342.0 4006.0 4113.0 1752.0 3846.0 5575.0 3727.0 2704.0 2289.0 3121.0 4207.0 4718.0 6279.0 5969.0 4866.0 3283.0 5702.0 4985.0 2871.0 4661.0 2931.0 2322.0 5014.0 4377.0 4839.0 2510.0 3228.0 5909.0 3893.0 6735.0 3182.0 5070.0 5046.0 3108.0 2893.0 3775.0 6658.0 1472.0 2232.0 2821.0 2590.0 3498.0 Unclassified; Cellular Processes and Signaling; Germination Glioma 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Cancers; Glioma Glutamatergic synapse 15303.0 16831.0 20430.0 17066.0 18615.0 18364.0 22794.0 22602.0 19103.0 21039.0 19346.0 17635.0 19428.0 19393.0 19100.0 19227.0 15363.0 15256.0 16828.0 19543.0 15548.0 16755.0 17745.0 21785.0 22073.0 19207.0 19986.0 17026.0 23991.0 18605.0 19871.0 23675.0 20875.0 19355.0 19650.0 21837.0 22280.0 21395.0 16915.0 13147.0 17597.0 22778.0 14826.0 15584.0 18311.0 21923.0 19380.0 13344.0 18017.0 12936.0 15159.0 Organismal Systems; Nervous System; Glutamatergic synapse Glutathione metabolism 28848.0 38122.0 35365.0 30119.0 29424.0 31687.0 37784.0 35720.0 28543.0 35789.0 34635.0 26809.0 31690.0 31770.0 37256.0 31231.0 29882.0 26239.0 28904.0 29635.0 25502.0 32188.0 30203.0 33636.0 33309.0 29629.0 27093.0 30939.0 33713.0 34431.0 31544.0 33155.0 31948.0 31427.0 29145.0 33902.0 32306.0 31141.0 38763.0 28547.0 30976.0 33731.0 28168.0 30168.0 32025.0 31914.0 37578.0 23175.0 31500.0 22314.0 29487.0 Metabolism; Metabolism of Other Amino Acids; Glutathione metabolism Glycan bindng proteins 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; Glycan bindng proteins Glycan biosynthesis and metabolism 6380.0 9551.0 5507.0 7071.0 6409.0 6307.0 7124.0 6528.0 5913.0 5936.0 6821.0 6464.0 6433.0 7722.0 7428.0 6589.0 6201.0 5890.0 5287.0 6059.0 5069.0 5980.0 5467.0 5233.0 5837.0 5324.0 5674.0 6734.0 3835.0 8966.0 5810.0 7654.0 5721.0 6537.0 5751.0 4620.0 4909.0 5136.0 6371.0 5660.0 5385.0 4905.0 5990.0 6968.0 9964.0 6116.0 5096.0 5078.0 6464.0 5922.0 5759.0 Unclassified; Metabolism; Glycan biosynthesis and metabolism Glycerolipid metabolism 49444.0 62566.0 74353.0 55425.0 48625.0 50914.0 67080.0 64771.0 48901.0 63664.0 49707.0 49502.0 39575.0 51149.0 62778.0 51202.0 43526.0 38910.0 49800.0 47338.0 45360.0 43950.0 46148.0 56240.0 49794.0 53441.0 51034.0 50192.0 68153.0 48866.0 42583.0 72525.0 50695.0 58771.0 44433.0 50316.0 61863.0 49255.0 52295.0 33281.0 66825.0 63046.0 32914.0 37824.0 57498.0 77198.0 51895.0 37547.0 42714.0 36431.0 39142.0 Metabolism; Lipid Metabolism; Glycerolipid metabolism Glycerophospholipid metabolism 79714.0 102393.0 100541.0 69090.0 79287.0 89435.0 103068.0 93686.0 81958.0 97635.0 80960.0 76672.0 70064.0 80766.0 108025.0 73635.0 68002.0 66499.0 83799.0 81729.0 72657.0 69151.0 76252.0 94059.0 81132.0 80569.0 86181.0 78682.0 101542.0 75379.0 74556.0 99052.0 80777.0 93265.0 84887.0 91131.0 103065.0 75116.0 89403.0 56421.0 87592.0 89234.0 67871.0 68863.0 85408.0 101271.0 90498.0 59449.0 70475.0 65585.0 68815.0 Metabolism; Lipid Metabolism; Glycerophospholipid metabolism Glycine, serine and threonine metabolism 117877.0 134362.0 136703.0 123003.0 121846.0 124280.0 160370.0 145800.0 122747.0 140439.0 131981.0 118439.0 118898.0 125253.0 135749.0 124603.0 119098.0 110722.0 124563.0 127811.0 115524.0 116432.0 120891.0 138076.0 130901.0 126246.0 126665.0 124007.0 149810.0 129657.0 121436.0 153700.0 128349.0 132656.0 121580.0 138195.0 142149.0 124177.0 132943.0 107283.0 137305.0 143274.0 107605.0 114617.0 126640.0 154040.0 132931.0 104547.0 109790.0 107956.0 115148.0 Metabolism; Amino Acid Metabolism; Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis 158908.0 183541.0 206679.0 162861.0 159013.0 173643.0 205838.0 199314.0 157183.0 193065.0 168412.0 159238.0 145142.0 168212.0 187733.0 166605.0 145095.0 142554.0 159986.0 161055.0 152450.0 148113.0 156952.0 182539.0 181019.0 168317.0 158585.0 159735.0 203376.0 162747.0 163173.0 228993.0 171897.0 179897.0 161977.0 176248.0 201766.0 172278.0 168931.0 122853.0 178627.0 203093.0 130627.0 136022.0 162803.0 215439.0 178118.0 134834.0 156556.0 136874.0 141283.0 Metabolism; Carbohydrate Metabolism; Glycolysis / Gluconeogenesis Glycosaminoglycan biosynthesis - chondroitin sulfate 1.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 95.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosaminoglycan biosynthesis - chondroitin sulfate Glycosaminoglycan degradation 21291.0 15613.0 23747.0 26397.0 26619.0 43535.0 29043.0 31961.0 24121.0 26322.0 24549.0 25084.0 31944.0 24966.0 20113.0 27145.0 20140.0 28903.0 24091.0 30436.0 21872.0 18263.0 22097.0 27913.0 38201.0 23572.0 24457.0 26076.0 32377.0 25901.0 30558.0 26984.0 32535.0 25158.0 48518.0 36590.0 28530.0 35310.0 20472.0 14847.0 25363.0 32395.0 16175.0 16267.0 20422.0 22918.0 40074.0 26071.0 29063.0 24230.0 17606.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosaminoglycan degradation Glycosphingolipid biosynthesis - ganglio series 15721.0 10030.0 15377.0 18897.0 20297.0 29428.0 20712.0 22115.0 17912.0 18320.0 18158.0 17089.0 24121.0 18251.0 14156.0 20074.0 15269.0 21624.0 16421.0 21568.0 17104.0 13801.0 16644.0 20369.0 26647.0 16513.0 19066.0 18110.0 24304.0 19133.0 21789.0 19716.0 23179.0 17687.0 32024.0 23677.0 19164.0 25442.0 13385.0 12693.0 17315.0 22926.0 13197.0 13797.0 14706.0 15722.0 23585.0 19972.0 20542.0 19567.0 14899.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosphingolipid biosynthesis - ganglio series Glycosphingolipid biosynthesis - globo series 26052.0 19608.0 28004.0 30649.0 31308.0 44654.0 37660.0 36967.0 28186.0 32256.0 27888.0 27262.0 33942.0 28398.0 25775.0 29756.0 24816.0 31299.0 27381.0 32991.0 27962.0 22467.0 27158.0 32755.0 39190.0 27936.0 30015.0 27475.0 40487.0 28296.0 31219.0 34481.0 35597.0 29607.0 47016.0 34160.0 31828.0 37963.0 22303.0 21184.0 34902.0 35491.0 20670.0 22195.0 24765.0 32054.0 33483.0 29874.0 29394.0 29695.0 23451.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosphingolipid biosynthesis - globo series Glycosphingolipid biosynthesis - lacto and neolacto series 195.0 78.0 112.0 289.0 130.0 2097.0 331.0 138.0 84.0 209.0 113.0 133.0 286.0 90.0 143.0 66.0 106.0 322.0 171.0 622.0 74.0 56.0 102.0 197.0 471.0 175.0 161.0 239.0 298.0 235.0 240.0 114.0 356.0 299.0 2665.0 288.0 318.0 137.0 118.0 33.0 389.0 377.0 63.0 22.0 19.0 88.0 531.0 341.0 182.0 61.0 70.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosphingolipid biosynthesis - lacto and neolacto series Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis Glycosyltransferases 48239.0 60395.0 57343.0 60034.0 54871.0 55928.0 72069.0 64882.0 50850.0 66564.0 59738.0 52299.0 54069.0 57432.0 66883.0 55892.0 55747.0 49210.0 52197.0 53914.0 46938.0 56547.0 58328.0 62416.0 61149.0 54543.0 50831.0 57933.0 62720.0 62322.0 56838.0 63993.0 60673.0 57497.0 50462.0 61414.0 61117.0 59633.0 68647.0 53031.0 57648.0 64928.0 46873.0 54656.0 63215.0 63999.0 72934.0 43013.0 53473.0 44052.0 55905.0 Metabolism; Glycan Biosynthesis and Metabolism; Glycosyltransferases Glyoxylate and dicarboxylate metabolism 79370.0 92763.0 93832.0 81846.0 80599.0 83016.0 100732.0 97025.0 83373.0 95024.0 83161.0 77389.0 83381.0 85960.0 91474.0 87038.0 74625.0 73112.0 82155.0 83652.0 71392.0 62046.0 68748.0 92183.0 86986.0 77856.0 81067.0 87103.0 100168.0 82177.0 79888.0 101217.0 83449.0 91134.0 84423.0 92285.0 95552.0 81359.0 74105.0 51014.0 92364.0 97451.0 57590.0 61841.0 87303.0 107621.0 92871.0 65193.0 74142.0 67201.0 58854.0 Metabolism; Carbohydrate Metabolism; Glyoxylate and dicarboxylate metabolism GnRH signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Endocrine System; GnRH signaling pathway Hedgehog signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; Hedgehog signaling pathway Hematopoietic cell lineage 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Immune System; Hematopoietic cell lineage Hepatitis C 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Infectious Diseases; Hepatitis C Histidine metabolism 95462.0 100592.0 114144.0 104009.0 104920.0 107994.0 124162.0 122201.0 103374.0 116372.0 103734.0 103773.0 103548.0 103856.0 109000.0 101692.0 91187.0 94237.0 102234.0 108845.0 93329.0 81956.0 93335.0 115873.0 113163.0 107577.0 108917.0 104303.0 129732.0 104611.0 100668.0 131594.0 111532.0 110920.0 110626.0 113796.0 126373.0 110820.0 91153.0 63773.0 105554.0 123587.0 66408.0 73894.0 101396.0 128130.0 98454.0 86663.0 90834.0 88434.0 73724.0 Metabolism; Amino Acid Metabolism; Histidine metabolism Homologous recombination 134215.0 153697.0 164056.0 142851.0 138634.0 141264.0 181933.0 163658.0 132638.0 162541.0 150474.0 135330.0 124055.0 144930.0 160662.0 136196.0 132902.0 127794.0 136660.0 134707.0 135544.0 144156.0 147920.0 150368.0 144492.0 147650.0 132630.0 137804.0 160748.0 148523.0 134075.0 181387.0 142593.0 146397.0 127756.0 140553.0 160822.0 141511.0 159590.0 133420.0 149693.0 158899.0 132890.0 142548.0 153640.0 172094.0 132482.0 122981.0 129730.0 123639.0 142221.0 Genetic Information Processing; Replication and Repair; Homologous recombination Huntington's disease 4732.0 5135.0 5359.0 3971.0 4710.0 5961.0 4980.0 5081.0 3967.0 4574.0 5118.0 4688.0 4735.0 4934.0 4774.0 5323.0 4669.0 4468.0 4802.0 4309.0 4226.0 3174.0 3057.0 4233.0 4245.0 3872.0 4389.0 4970.0 4027.0 6440.0 4568.0 3768.0 4640.0 4921.0 4286.0 5546.0 3471.0 4344.0 6129.0 2149.0 4908.0 4099.0 1139.0 2176.0 6452.0 4992.0 7228.0 3810.0 4444.0 4654.0 1881.0 Human Diseases; Neurodegenerative Diseases; Huntington's disease Hypertrophic cardiomyopathy (HCM) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Cardiovascular Diseases; Hypertrophic cardiomyopathy (HCM) Indole alkaloid biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Indole alkaloid biosynthesis Influenza A 3.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 13.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 2.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Human Diseases; Infectious Diseases; Influenza A Inorganic ion transport and metabolism 31238.0 36419.0 37362.0 30857.0 31298.0 39872.0 42297.0 41563.0 29625.0 37489.0 33543.0 30092.0 32999.0 32315.0 38146.0 33373.0 28025.0 28924.0 34777.0 36088.0 26438.0 24577.0 29062.0 38522.0 40221.0 31829.0 31970.0 35950.0 38963.0 35171.0 37222.0 41319.0 37970.0 36120.0 36043.0 41447.0 38517.0 35897.0 32181.0 20953.0 37930.0 37587.0 22289.0 24518.0 34379.0 41948.0 54207.0 24728.0 29744.0 26872.0 24304.0 Unclassified; Cellular Processes and Signaling; Inorganic ion transport and metabolism Inositol phosphate metabolism 14530.0 22414.0 13962.0 16342.0 15206.0 16319.0 16414.0 19752.0 14768.0 16347.0 15398.0 16036.0 15216.0 15845.0 19042.0 17682.0 15366.0 15066.0 15069.0 16675.0 14053.0 12419.0 13362.0 16383.0 18274.0 15700.0 16608.0 15189.0 18313.0 18743.0 13819.0 18841.0 15838.0 16275.0 15071.0 17069.0 17724.0 16538.0 15234.0 10494.0 20775.0 21489.0 9030.0 10659.0 17707.0 20813.0 19012.0 13794.0 16308.0 14627.0 12332.0 Metabolism; Carbohydrate Metabolism; Inositol phosphate metabolism Insulin signaling pathway 12059.0 15688.0 16294.0 14837.0 13492.0 16109.0 18200.0 17431.0 12869.0 17786.0 14161.0 12857.0 10930.0 15005.0 18739.0 13010.0 10419.0 10810.0 11865.0 12853.0 10592.0 10087.0 12068.0 15804.0 16302.0 12476.0 11828.0 13973.0 17644.0 12643.0 13063.0 22692.0 14890.0 16044.0 17036.0 14126.0 17535.0 15309.0 10821.0 9070.0 14506.0 15984.0 10544.0 10762.0 13299.0 19613.0 15150.0 9370.0 14040.0 8544.0 10566.0 Organismal Systems; Endocrine System; Insulin signaling pathway Ion channels 1497.0 3060.0 2380.0 2328.0 984.0 3129.0 1733.0 1307.0 1015.0 1574.0 1159.0 2515.0 1130.0 935.0 2334.0 1264.0 950.0 1613.0 2388.0 2542.0 1212.0 1317.0 1370.0 1210.0 2581.0 2110.0 1300.0 2431.0 1466.0 1637.0 2567.0 2161.0 2312.0 1812.0 3252.0 3521.0 2039.0 1395.0 1704.0 460.0 1812.0 2381.0 422.0 668.0 960.0 2611.0 5556.0 1405.0 1965.0 1169.0 945.0 Environmental Information Processing; Signaling Molecules and Interaction; Ion channels Isoflavonoid biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Isoflavonoid biosynthesis Isoquinoline alkaloid biosynthesis 9002.0 9327.0 10083.0 9978.0 9032.0 9247.0 10596.0 10164.0 9458.0 9776.0 8886.0 8824.0 10580.0 8762.0 9772.0 9706.0 10626.0 9588.0 9824.0 10743.0 8780.0 8931.0 10125.0 10159.0 10193.0 8057.0 9770.0 10864.0 10837.0 9290.0 9469.0 9018.0 9896.0 9300.0 9981.0 11231.0 10535.0 9340.0 9758.0 10553.0 9721.0 10995.0 10480.0 11195.0 9461.0 9482.0 11444.0 9069.0 7934.0 9277.0 11014.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Isoquinoline alkaloid biosynthesis Leishmaniasis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Infectious Diseases; Leishmaniasis Leukocyte transendothelial migration 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Immune System; Leukocyte transendothelial migration Limonene and pinene degradation 12046.0 12610.0 15415.0 13120.0 10869.0 11557.0 14725.0 13121.0 9473.0 12046.0 13109.0 12993.0 9299.0 11435.0 9447.0 12104.0 10066.0 10432.0 12646.0 9971.0 10111.0 10023.0 10944.0 10356.0 10735.0 11017.0 11265.0 13159.0 11011.0 13497.0 10032.0 14549.0 11737.0 11907.0 7666.0 12311.0 11060.0 11027.0 12548.0 8029.0 13682.0 13798.0 6806.0 9007.0 15826.0 16006.0 19431.0 9990.0 8433.0 10373.0 9509.0 Metabolism; Metabolism of Terpenoids and Polyketides; Limonene and pinene degradation Linoleic acid metabolism 10947.0 11308.0 14510.0 13086.0 12557.0 13077.0 18176.0 15764.0 11747.0 14597.0 11924.0 11099.0 12904.0 13410.0 12733.0 14543.0 10595.0 12065.0 11496.0 12443.0 11103.0 8790.0 8669.0 14048.0 15566.0 11446.0 12020.0 12212.0 15999.0 13841.0 12572.0 16243.0 13886.0 13486.0 12990.0 13599.0 14646.0 13459.0 10062.0 5547.0 12403.0 16206.0 5180.0 6621.0 14609.0 17389.0 14466.0 10368.0 11122.0 10510.0 6955.0 Metabolism; Lipid Metabolism; Linoleic acid metabolism Lipid biosynthesis proteins 85413.0 102139.0 103420.0 93160.0 93742.0 94354.0 115918.0 113206.0 90716.0 110673.0 100481.0 86430.0 87148.0 100283.0 106913.0 93654.0 87505.0 79165.0 89199.0 92379.0 82764.0 88097.0 87771.0 103671.0 100013.0 92467.0 90619.0 88287.0 111740.0 100726.0 97566.0 122457.0 97826.0 100536.0 93802.0 101511.0 109324.0 93471.0 104657.0 73158.0 94397.0 104161.0 76669.0 81478.0 103962.0 116526.0 102634.0 72009.0 87069.0 73192.0 78799.0 Metabolism; Lipid Metabolism; Lipid biosynthesis proteins Lipid metabolism 16879.0 23598.0 23817.0 18770.0 18426.0 16836.0 25869.0 25605.0 18354.0 25606.0 20366.0 17469.0 15666.0 21107.0 25429.0 19298.0 18093.0 14414.0 17669.0 17110.0 16346.0 19396.0 20735.0 22645.0 21008.0 20477.0 16527.0 17783.0 23922.0 18595.0 17557.0 26533.0 20969.0 22117.0 15278.0 19608.0 24166.0 20831.0 22619.0 16415.0 21525.0 23265.0 16730.0 18538.0 23995.0 26999.0 20259.0 12662.0 18579.0 11882.0 17287.0 Unclassified; Metabolism; Lipid metabolism Lipoic acid metabolism 6703.0 6025.0 6889.0 8162.0 8318.0 11729.0 8983.0 9365.0 7932.0 6794.0 7655.0 6786.0 10323.0 7781.0 6711.0 8496.0 6065.0 7953.0 7102.0 9446.0 6766.0 4618.0 5022.0 8509.0 10681.0 6845.0 10285.0 7663.0 9704.0 9138.0 10127.0 10052.0 8803.0 8368.0 10885.0 9952.0 7228.0 9611.0 5893.0 2761.0 7171.0 8621.0 1580.0 2109.0 5578.0 8664.0 10657.0 7026.0 8412.0 7323.0 2813.0 Metabolism; Metabolism of Cofactors and Vitamins; Lipoic acid metabolism Lipopolysaccharide biosynthesis 46298.0 50409.0 37594.0 63331.0 51684.0 56817.0 56643.0 50137.0 46110.0 50694.0 60069.0 52576.0 62808.0 54958.0 47923.0 53891.0 66438.0 60014.0 57183.0 57704.0 46514.0 55623.0 51441.0 51895.0 56610.0 44851.0 49863.0 65313.0 45072.0 73742.0 58176.0 51510.0 53150.0 46860.0 54279.0 62298.0 41326.0 50121.0 79697.0 58976.0 53168.0 50765.0 48833.0 59497.0 69223.0 51404.0 86076.0 52719.0 44222.0 56722.0 55798.0 Metabolism; Glycan Biosynthesis and Metabolism; Lipopolysaccharide biosynthesis Lipopolysaccharide biosynthesis proteins 65038.0 72680.0 59670.0 83198.0 69650.0 79205.0 81261.0 74583.0 63964.0 69817.0 80836.0 73837.0 82969.0 72633.0 66272.0 74470.0 84604.0 77063.0 75146.0 77751.0 63189.0 73565.0 66209.0 73304.0 80502.0 66073.0 70336.0 84941.0 68448.0 95921.0 85380.0 71454.0 74794.0 66092.0 75429.0 83032.0 65922.0 71982.0 99110.0 69945.0 73899.0 72732.0 58890.0 70555.0 83882.0 75185.0 106548.0 68246.0 62930.0 72021.0 67660.0 Metabolism; Glycan Biosynthesis and Metabolism; Lipopolysaccharide biosynthesis proteins Long-term depression 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Nervous System; Long-term depression Long-term potentiation 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Nervous System; Long-term potentiation Lysine biosynthesis 119377.0 136309.0 149108.0 118353.0 119256.0 114231.0 164582.0 145014.0 120743.0 144966.0 129066.0 115854.0 110632.0 124427.0 142867.0 120342.0 110091.0 108063.0 122180.0 120594.0 115839.0 110502.0 115340.0 138846.0 126640.0 125674.0 120006.0 119632.0 152923.0 120774.0 113213.0 159266.0 123676.0 131719.0 117101.0 130012.0 149448.0 119940.0 130298.0 91731.0 134165.0 144274.0 100371.0 105724.0 125728.0 155904.0 114588.0 102550.0 108450.0 103013.0 103850.0 Metabolism; Amino Acid Metabolism; Lysine biosynthesis Lysine degradation 17576.0 23097.0 22607.0 19628.0 16498.0 19847.0 22364.0 21547.0 16909.0 21415.0 20545.0 17785.0 16547.0 17860.0 21059.0 18282.0 15470.0 13858.0 18681.0 17018.0 14207.0 15863.0 15993.0 18945.0 17259.0 16936.0 16711.0 18175.0 19915.0 19121.0 16554.0 20187.0 18418.0 19780.0 17194.0 21314.0 20538.0 16671.0 22083.0 11332.0 18124.0 21659.0 11929.0 13728.0 20846.0 23463.0 28039.0 11944.0 15219.0 10460.0 13447.0 Metabolism; Amino Acid Metabolism; Lysine degradation Lysosome 27974.0 19668.0 29944.0 33907.0 34911.0 58457.0 36792.0 43206.0 32678.0 34065.0 32375.0 35389.0 42551.0 32268.0 24185.0 34820.0 28409.0 38254.0 34370.0 44306.0 30308.0 25216.0 29539.0 37733.0 49857.0 34051.0 36901.0 34696.0 44713.0 36021.0 41235.0 38866.0 43248.0 33447.0 64834.0 48447.0 37852.0 45130.0 28191.0 20867.0 41856.0 42029.0 21598.0 22163.0 28226.0 36049.0 52180.0 34044.0 34712.0 33047.0 23425.0 Cellular Processes; Transport and Catabolism; Lysosome MAPK signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; MAPK signaling pathway MAPK signaling pathway - yeast 7829.0 6127.0 8530.0 8296.0 8589.0 9664.0 12345.0 9273.0 8569.0 7717.0 9511.0 9048.0 9937.0 7858.0 6505.0 8762.0 8299.0 8303.0 8607.0 10190.0 8881.0 7333.0 6524.0 9395.0 9474.0 9730.0 11259.0 8813.0 11559.0 8986.0 9512.0 8601.0 9256.0 7917.0 8985.0 10092.0 8963.0 9600.0 8394.0 3938.0 8339.0 10006.0 3090.0 3181.0 6298.0 9253.0 8193.0 8247.0 7305.0 8350.0 4035.0 Environmental Information Processing; Signal Transduction; MAPK signaling pathway - yeast Measles 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Infectious Diseases; Measles Meiosis - yeast 311.0 485.0 41.0 554.0 686.0 261.0 456.0 518.0 411.0 658.0 489.0 947.0 461.0 1179.0 370.0 683.0 316.0 410.0 1601.0 828.0 209.0 446.0 542.0 297.0 318.0 398.0 375.0 1255.0 14.0 1114.0 194.0 833.0 757.0 467.0 170.0 2173.0 116.0 366.0 1295.0 82.0 577.0 364.0 187.0 616.0 1985.0 635.0 3601.0 195.0 229.0 611.0 274.0 Cellular Processes; Cell Growth and Death; Meiosis - yeast Melanogenesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Endocrine System; Melanogenesis Membrane and intracellular structural molecules 95805.0 105419.0 97131.0 107403.0 113023.0 132772.0 126146.0 123923.0 100081.0 115859.0 111895.0 98332.0 119763.0 112182.0 113199.0 114700.0 105569.0 108657.0 98873.0 113418.0 91279.0 92282.0 99558.0 116005.0 130671.0 95657.0 102073.0 113055.0 122190.0 123978.0 120847.0 113203.0 120606.0 110219.0 134882.0 122302.0 113659.0 119082.0 98264.0 94878.0 100953.0 120906.0 91325.0 102915.0 126143.0 112319.0 138173.0 92807.0 106767.0 102015.0 101876.0 Unclassified; Cellular Processes and Signaling; Membrane and intracellular structural molecules Metabolism of cofactors and vitamins 15223.0 23387.0 19672.0 15929.0 15253.0 13448.0 16228.0 17046.0 14961.0 15791.0 14702.0 13926.0 16714.0 17107.0 20425.0 18550.0 16814.0 15075.0 16709.0 14497.0 12423.0 11856.0 14418.0 15608.0 16583.0 11480.0 13786.0 17286.0 13573.0 18531.0 12793.0 16901.0 14548.0 18136.0 14158.0 20172.0 15738.0 12719.0 15327.0 13287.0 13752.0 17724.0 14304.0 17357.0 25484.0 19101.0 27958.0 11796.0 15352.0 13368.0 14784.0 Unclassified; Metabolism; Metabolism of cofactors and vitamins Metabolism of xenobiotics by cytochrome P450 4487.0 5921.0 4665.0 4838.0 4087.0 3233.0 6470.0 6114.0 3247.0 4769.0 4529.0 3414.0 3725.0 5610.0 3810.0 4446.0 2814.0 3747.0 3809.0 2974.0 3305.0 2118.0 2435.0 3402.0 4800.0 2458.0 2488.0 3903.0 3147.0 4912.0 2788.0 8419.0 4034.0 4013.0 1210.0 4115.0 2837.0 5127.0 2924.0 1182.0 4431.0 4328.0 927.0 1665.0 5668.0 5461.0 6738.0 3546.0 4639.0 3617.0 1384.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Metabolism of xenobiotics by cytochrome P450 Methane metabolism 169793.0 191360.0 221612.0 171891.0 177675.0 179734.0 224419.0 217078.0 169283.0 208988.0 188678.0 169620.0 165132.0 182041.0 194020.0 185451.0 160467.0 160800.0 173673.0 188100.0 171179.0 165323.0 172964.0 198091.0 197616.0 189554.0 189279.0 171161.0 230688.0 182184.0 168191.0 235705.0 188812.0 196327.0 171608.0 181103.0 208551.0 190227.0 182660.0 131816.0 201902.0 222486.0 127735.0 143832.0 192366.0 241203.0 168630.0 147259.0 154027.0 152795.0 148844.0 Metabolism; Energy Metabolism; Methane metabolism Mineral absorption 330.0 738.0 636.0 600.0 195.0 352.0 220.0 393.0 218.0 265.0 296.0 630.0 803.0 399.0 1066.0 808.0 1033.0 541.0 557.0 1052.0 490.0 2135.0 2526.0 149.0 644.0 516.0 816.0 532.0 170.0 325.0 142.0 369.0 454.0 394.0 433.0 385.0 275.0 512.0 1448.0 3331.0 394.0 730.0 3398.0 3490.0 676.0 609.0 1108.0 288.0 445.0 326.0 3282.0 Organismal Systems; Digestive System; Mineral absorption Mismatch repair 117434.0 129905.0 149424.0 124263.0 119110.0 124426.0 156553.0 141090.0 112360.0 142103.0 129656.0 115419.0 105648.0 122045.0 138652.0 116017.0 113973.0 110583.0 119270.0 118744.0 120007.0 124657.0 128174.0 130800.0 125992.0 129814.0 115246.0 119152.0 146500.0 124507.0 116968.0 154247.0 125848.0 126316.0 113818.0 121650.0 138956.0 123549.0 138058.0 114738.0 131447.0 137891.0 110701.0 119228.0 125914.0 149881.0 117366.0 107068.0 109187.0 107658.0 121562.0 Genetic Information Processing; Replication and Repair; Mismatch repair N-Glycan biosynthesis 3227.0 2620.0 2622.0 3333.0 3809.0 4057.0 3656.0 4106.0 3468.0 3828.0 4511.0 3835.0 4506.0 3762.0 2657.0 4481.0 5150.0 4092.0 4606.0 4730.0 4039.0 5431.0 4796.0 4440.0 4528.0 4099.0 4655.0 4518.0 4396.0 4636.0 5690.0 3869.0 4310.0 3769.0 4266.0 6031.0 3910.0 4375.0 6730.0 5134.0 4764.0 4913.0 4199.0 4534.0 2960.0 4350.0 6867.0 3613.0 2866.0 4060.0 5099.0 Metabolism; Glycan Biosynthesis and Metabolism; N-Glycan biosynthesis NOD-like receptor signaling pathway 6740.0 6791.0 8527.0 7688.0 7622.0 8195.0 9407.0 9211.0 7521.0 8942.0 7579.0 7091.0 6836.0 8013.0 8101.0 7358.0 5985.0 6221.0 6526.0 7653.0 6448.0 6490.0 7378.0 8272.0 8273.0 7532.0 6636.0 7492.0 9273.0 7119.0 7092.0 9977.0 8474.0 7798.0 8768.0 8027.0 8721.0 8317.0 5614.0 6829.0 7623.0 8153.0 6959.0 7160.0 7885.0 8537.0 7017.0 6061.0 7059.0 5876.0 7123.0 Organismal Systems; Immune System; NOD-like receptor signaling pathway Naphthalene degradation 20289.0 17843.0 25308.0 22741.0 20711.0 19791.0 28913.0 26724.0 17868.0 21999.0 21315.0 21020.0 20258.0 21855.0 18894.0 21277.0 18910.0 20522.0 21624.0 20951.0 20798.0 17745.0 20077.0 20823.0 24367.0 20825.0 21581.0 22170.0 25510.0 23226.0 19284.0 35704.0 22992.0 21287.0 16897.0 22768.0 21187.0 24112.0 18511.0 15067.0 23300.0 24302.0 13475.0 16014.0 22875.0 29438.0 27896.0 19980.0 18693.0 20631.0 16279.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Naphthalene degradation Neuroactive ligand-receptor interaction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signaling Molecules and Interaction; Neuroactive ligand-receptor interaction Neurotrophin signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Nervous System; Neurotrophin signaling pathway Nicotinate and nicotinamide metabolism 63452.0 71885.0 74559.0 63109.0 64364.0 66261.0 79258.0 75658.0 61182.0 76407.0 69104.0 60999.0 56037.0 66143.0 73411.0 61115.0 63290.0 57153.0 59908.0 61892.0 60615.0 62904.0 63622.0 70833.0 66018.0 62758.0 61251.0 63834.0 75689.0 68398.0 58054.0 87379.0 66042.0 69237.0 63044.0 61155.0 75519.0 63049.0 68411.0 61005.0 68394.0 71820.0 60430.0 64497.0 68907.0 80094.0 52704.0 54552.0 55647.0 57749.0 65360.0 Metabolism; Metabolism of Cofactors and Vitamins; Nicotinate and nicotinamide metabolism Nitrogen metabolism 110095.0 127955.0 136417.0 113854.0 120619.0 122428.0 140346.0 133217.0 117869.0 131959.0 117241.0 111879.0 117458.0 121840.0 133131.0 124004.0 102476.0 105839.0 106951.0 123620.0 103046.0 102460.0 108116.0 127560.0 126249.0 112936.0 122123.0 117848.0 141199.0 123624.0 112245.0 127473.0 126018.0 125145.0 121975.0 120647.0 130447.0 121111.0 107862.0 87677.0 120865.0 133603.0 91043.0 101162.0 140594.0 133025.0 120189.0 94597.0 110902.0 100346.0 98238.0 Metabolism; Energy Metabolism; Nitrogen metabolism Nitrotoluene degradation 9550.0 14287.0 14602.0 10064.0 11502.0 6050.0 7888.0 9900.0 9203.0 12473.0 10306.0 9606.0 6619.0 12550.0 12537.0 12039.0 6107.0 7581.0 8330.0 9737.0 7299.0 8592.0 9055.0 9650.0 7015.0 7727.0 8861.0 10436.0 8976.0 12631.0 7405.0 6788.0 9472.0 11033.0 5393.0 8370.0 10515.0 6393.0 9423.0 4743.0 8753.0 11039.0 5431.0 8517.0 23221.0 11975.0 11353.0 5691.0 7075.0 7934.0 7710.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Nitrotoluene degradation Non-homologous end-joining 559.0 1177.0 329.0 1816.0 520.0 2722.0 1572.0 1641.0 393.0 764.0 780.0 1022.0 609.0 1135.0 1216.0 903.0 1121.0 1087.0 1880.0 1105.0 309.0 668.0 709.0 514.0 1916.0 510.0 675.0 1084.0 515.0 1900.0 692.0 5466.0 815.0 1311.0 2994.0 3457.0 636.0 644.0 2164.0 390.0 969.0 1142.0 268.0 501.0 206.0 3231.0 6177.0 387.0 936.0 323.0 310.0 Genetic Information Processing; Replication and Repair; Non-homologous end-joining Notch signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; Notch signaling pathway Novobiocin biosynthesis 20198.0 24387.0 23260.0 21175.0 19926.0 20585.0 25948.0 23335.0 20265.0 24099.0 21496.0 19896.0 19788.0 20934.0 24868.0 20337.0 20663.0 19302.0 20723.0 21492.0 18915.0 18964.0 19596.0 22760.0 21509.0 20284.0 19890.0 22293.0 23820.0 21680.0 19106.0 23684.0 21221.0 22241.0 21607.0 21442.0 24712.0 19696.0 22763.0 16852.0 22306.0 23989.0 17274.0 19113.0 22800.0 24755.0 20381.0 17583.0 18140.0 17823.0 18312.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Novobiocin biosynthesis Nucleotide excision repair 52372.0 60887.0 67769.0 54982.0 54531.0 57231.0 67605.0 66319.0 52560.0 66968.0 60242.0 53104.0 49448.0 58260.0 64401.0 53647.0 55018.0 49272.0 56436.0 55146.0 52270.0 59170.0 61624.0 61999.0 58098.0 59454.0 53030.0 56829.0 66761.0 60075.0 53622.0 73156.0 57877.0 59865.0 54580.0 60189.0 65693.0 55821.0 68166.0 57030.0 61323.0 61894.0 58488.0 60477.0 62178.0 71583.0 60442.0 45599.0 49322.0 46892.0 59652.0 Genetic Information Processing; Replication and Repair; Nucleotide excision repair Nucleotide metabolism 5032.0 7586.0 8405.0 6102.0 3908.0 4268.0 7009.0 4304.0 3458.0 6045.0 5288.0 5003.0 3799.0 3383.0 6830.0 5606.0 4700.0 3458.0 5116.0 4433.0 4934.0 7204.0 5718.0 4320.0 3275.0 5428.0 5956.0 5158.0 5495.0 4367.0 5372.0 3276.0 4483.0 5619.0 2753.0 3466.0 4954.0 4476.0 10017.0 2672.0 4822.0 6237.0 2181.0 3042.0 2602.0 5808.0 5285.0 3084.0 2908.0 2961.0 3417.0 Unclassified; Metabolism; Nucleotide metabolism Olfactory transduction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Sensory System; Olfactory transduction One carbon pool by folate 92941.0 100094.0 111054.0 94751.0 96381.0 95946.0 117791.0 111680.0 96114.0 110906.0 103670.0 92808.0 92635.0 96883.0 109309.0 94825.0 95227.0 88387.0 97255.0 99042.0 93261.0 99049.0 106492.0 108841.0 102293.0 101206.0 99719.0 98273.0 118070.0 96632.0 93064.0 115522.0 101211.0 101653.0 94342.0 103667.0 115738.0 100323.0 107966.0 101939.0 103977.0 111710.0 103073.0 106549.0 96160.0 116132.0 96440.0 85058.0 87591.0 87034.0 107795.0 Metabolism; Metabolism of Cofactors and Vitamins; One carbon pool by folate Oocyte meiosis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Growth and Death; Oocyte meiosis Other glycan degradation 69610.0 54723.0 83313.0 79794.0 81564.0 111012.0 93581.0 107205.0 74546.0 90592.0 75644.0 76978.0 89248.0 78055.0 73667.0 84915.0 64343.0 88526.0 74353.0 92486.0 75456.0 56021.0 65816.0 93156.0 116996.0 79588.0 71471.0 80937.0 104363.0 81000.0 89357.0 94595.0 104611.0 79927.0 121573.0 91584.0 96587.0 108679.0 52555.0 45865.0 98445.0 104508.0 48097.0 49605.0 73828.0 91843.0 91927.0 82980.0 85675.0 81055.0 53011.0 Metabolism; Glycan Biosynthesis and Metabolism; Other glycan degradation Other ion-coupled transporters 213217.0 254850.0 254557.0 222428.0 225080.0 234502.0 285052.0 256886.0 222622.0 259605.0 221699.0 204909.0 228156.0 236358.0 257653.0 243053.0 203077.0 209881.0 210778.0 224059.0 193234.0 189399.0 192341.0 249602.0 244492.0 208856.0 209999.0 241027.0 260450.0 245099.0 230832.0 237790.0 232747.0 239644.0 244571.0 228776.0 259808.0 217224.0 218472.0 156917.0 239653.0 264159.0 178345.0 195087.0 272462.0 260848.0 241122.0 185143.0 208341.0 190989.0 185756.0 Unclassified; Cellular Processes and Signaling; Other ion-coupled transporters Other transporters 43702.0 50092.0 53926.0 43602.0 43592.0 48828.0 54552.0 50338.0 41855.0 50326.0 43920.0 41607.0 42023.0 46172.0 49424.0 44769.0 38795.0 40456.0 42593.0 44720.0 40415.0 38963.0 37975.0 46860.0 47431.0 42920.0 43415.0 44945.0 51211.0 47489.0 44375.0 55629.0 45101.0 48310.0 50063.0 43838.0 49222.0 42431.0 44522.0 29264.0 46270.0 47843.0 31905.0 35172.0 49061.0 54643.0 45137.0 36595.0 38849.0 37757.0 33424.0 Unclassified; Cellular Processes and Signaling; Other transporters Other types of O-glycan biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Glycan Biosynthesis and Metabolism; Other types of O-glycan biosynthesis Others 126602.0 147755.0 185456.0 138293.0 135586.0 167507.0 177127.0 174345.0 128266.0 168290.0 136647.0 132356.0 131284.0 141569.0 153498.0 141037.0 116982.0 119120.0 136191.0 146696.0 119658.0 115482.0 127726.0 151211.0 158607.0 142677.0 135391.0 138080.0 171897.0 143867.0 126114.0 165615.0 155840.0 151500.0 157534.0 150600.0 159384.0 151991.0 134794.0 87961.0 167259.0 169790.0 85364.0 99109.0 174062.0 179946.0 178576.0 103359.0 125153.0 105693.0 98366.0 Unclassified; Metabolism; Others Oxidative phosphorylation 170605.0 180572.0 198758.0 166730.0 183203.0 182644.0 213228.0 197016.0 174863.0 195365.0 181867.0 164414.0 172473.0 189495.0 177299.0 189594.0 159534.0 168254.0 173468.0 174013.0 161395.0 153383.0 168293.0 185986.0 180635.0 169619.0 170735.0 173468.0 206707.0 191277.0 158758.0 185852.0 179842.0 180371.0 177578.0 195657.0 190647.0 173356.0 164219.0 154154.0 174907.0 200389.0 158068.0 174023.0 223526.0 201277.0 192934.0 155285.0 154768.0 168103.0 172606.0 Metabolism; Energy Metabolism; Oxidative phosphorylation PPAR signaling pathway 17787.0 19227.0 20362.0 20912.0 21886.0 18990.0 22119.0 25110.0 21491.0 22651.0 21659.0 21338.0 21028.0 23664.0 21353.0 22579.0 19473.0 17588.0 18572.0 20954.0 17232.0 18605.0 18824.0 22998.0 22638.0 20853.0 20966.0 20119.0 23995.0 24251.0 23240.0 28295.0 22505.0 21440.0 20085.0 22996.0 24039.0 22053.0 18985.0 15592.0 20085.0 22810.0 17254.0 17854.0 25670.0 24764.0 21748.0 16637.0 20455.0 17147.0 16858.0 Organismal Systems; Endocrine System; PPAR signaling pathway Pancreatic cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Cancers; Pancreatic cancer Pancreatic secretion 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Digestive System; Pancreatic secretion Pantothenate and CoA biosynthesis 90981.0 105667.0 108609.0 92829.0 89780.0 88011.0 121106.0 108734.0 94262.0 108360.0 95876.0 90134.0 85216.0 91379.0 111944.0 91747.0 83006.0 82410.0 93653.0 93420.0 88280.0 83724.0 92941.0 105652.0 96977.0 94498.0 93377.0 93407.0 114834.0 83773.0 87583.0 109555.0 95467.0 101498.0 87381.0 103984.0 116547.0 94321.0 96064.0 74470.0 100033.0 113877.0 80564.0 82955.0 88477.0 115284.0 95956.0 79177.0 84373.0 79556.0 85163.0 Metabolism; Metabolism of Cofactors and Vitamins; Pantothenate and CoA biosynthesis Parkinson's disease 93.0 60.0 30.0 21.0 15.0 53.0 48.0 41.0 9.0 24.0 48.0 45.0 25.0 52.0 42.0 28.0 6.0 3.0 27.0 18.0 9.0 3.0 1.0 0.0 4.0 19.0 4.0 3.0 3.0 18.0 8.0 8.0 27.0 18.0 16.0 0.0 9.0 7.0 6.0 6.0 29.0 9.0 6.0 5.0 9.0 4.0 48.0 3.0 6.0 0.0 7.0 Human Diseases; Neurodegenerative Diseases; Parkinson's disease Pathogenic Escherichia coli infection 5.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Infectious Diseases; Pathogenic Escherichia coli infection Pathways in cancer 7047.0 7933.0 7481.0 7213.0 7568.0 8402.0 9216.0 8241.0 6892.0 8915.0 8302.0 7143.0 6641.0 8176.0 8242.0 6927.0 6717.0 6685.0 7721.0 7776.0 6572.0 7385.0 7261.0 7831.0 7240.0 7328.0 6668.0 8161.0 8059.0 8077.0 7943.0 9171.0 7726.0 7753.0 8940.0 8363.0 8115.0 6737.0 8254.0 6729.0 8212.0 7324.0 6971.0 7640.0 8498.0 8912.0 8523.0 5794.0 5907.0 6221.0 7043.0 Human Diseases; Cancers; Pathways in cancer Penicillin and cephalosporin biosynthesis 4742.0 4472.0 6154.0 7145.0 5541.0 4771.0 6527.0 7227.0 6301.0 6048.0 5920.0 5660.0 7889.0 6393.0 5549.0 7969.0 4796.0 5855.0 5821.0 5738.0 4589.0 3160.0 4696.0 6666.0 8033.0 4459.0 4530.0 5327.0 5951.0 5099.0 6643.0 6258.0 7010.0 5811.0 5240.0 9595.0 6193.0 8344.0 4491.0 1766.0 3684.0 8107.0 2772.0 2783.0 4972.0 5082.0 10884.0 5393.0 8545.0 4249.0 2141.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Penicillin and cephalosporin biosynthesis Pentose and glucuronate interconversions 91979.0 90518.0 130591.0 97150.0 94972.0 105614.0 105244.0 119033.0 102612.0 105040.0 92130.0 93307.0 99662.0 99583.0 89770.0 105103.0 77852.0 87070.0 87686.0 98058.0 88472.0 65540.0 69029.0 112030.0 114251.0 89485.0 102830.0 92702.0 123980.0 97716.0 99613.0 126755.0 102259.0 107078.0 114467.0 109913.0 113507.0 105847.0 74720.0 43866.0 108998.0 111071.0 58430.0 54937.0 90756.0 124536.0 104063.0 84649.0 98214.0 87788.0 54317.0 Metabolism; Carbohydrate Metabolism; Pentose and glucuronate interconversions Pentose phosphate pathway 127459.0 148359.0 171282.0 137081.0 127120.0 138069.0 163952.0 162409.0 131915.0 158538.0 134758.0 130546.0 117863.0 135200.0 150341.0 140430.0 114400.0 114138.0 127738.0 132986.0 124469.0 118757.0 119915.0 153619.0 147507.0 139392.0 133711.0 128390.0 172313.0 132941.0 135134.0 182715.0 141153.0 151569.0 131964.0 142222.0 163960.0 141789.0 136715.0 90672.0 149318.0 167105.0 99329.0 102538.0 128832.0 181729.0 140149.0 109083.0 123966.0 106399.0 106750.0 Metabolism; Carbohydrate Metabolism; Pentose phosphate pathway Peptidases 269030.0 316351.0 348659.0 263027.0 287750.0 279748.0 361130.0 343008.0 278850.0 336835.0 297436.0 266134.0 269481.0 298399.0 329812.0 290384.0 269769.0 246947.0 275925.0 281431.0 260295.0 277314.0 291425.0 320148.0 300218.0 289750.0 280690.0 280949.0 349068.0 293307.0 277080.0 350294.0 296644.0 311530.0 275472.0 300733.0 338035.0 290661.0 294223.0 268012.0 314048.0 328448.0 278419.0 296253.0 321440.0 357678.0 287228.0 225423.0 261421.0 237871.0 289407.0 Metabolism; Enzyme Families; Peptidases Peptidoglycan biosynthesis 111323.0 132588.0 137044.0 110895.0 113901.0 109104.0 148115.0 136532.0 113270.0 137342.0 127317.0 113172.0 99391.0 121246.0 134227.0 109129.0 113365.0 98264.0 113207.0 113468.0 109277.0 125026.0 123275.0 128758.0 118734.0 120084.0 114784.0 113586.0 135715.0 122055.0 108431.0 154766.0 117591.0 124352.0 112795.0 121010.0 138472.0 113216.0 136913.0 121401.0 127810.0 129097.0 123538.0 128415.0 125159.0 145933.0 110546.0 92748.0 108386.0 96218.0 127533.0 Metabolism; Glycan Biosynthesis and Metabolism; Peptidoglycan biosynthesis Peroxisome 29924.0 29926.0 31379.0 27850.0 32982.0 34859.0 35120.0 36730.0 31371.0 33493.0 32792.0 30464.0 33315.0 32787.0 32281.0 33193.0 30191.0 30254.0 30498.0 33552.0 29437.0 26503.0 27772.0 34592.0 34461.0 31125.0 32850.0 31721.0 36546.0 34943.0 34869.0 36127.0 33990.0 33080.0 35888.0 34142.0 35491.0 32104.0 28646.0 24044.0 33115.0 34190.0 24601.0 25782.0 35378.0 35132.0 31337.0 28161.0 29804.0 30908.0 25479.0 Cellular Processes; Transport and Catabolism; Peroxisome Pertussis 8823.0 6683.0 7945.0 6367.0 6871.0 10806.0 11549.0 8013.0 6627.0 6162.0 8077.0 5871.0 8759.0 6108.0 5263.0 7047.0 5596.0 7118.0 5431.0 6528.0 5832.0 3048.0 3328.0 6709.0 7838.0 5260.0 6113.0 5564.0 7798.0 6561.0 7819.0 6493.0 7270.0 6864.0 7758.0 6614.0 6130.0 7889.0 2447.0 2128.0 5139.0 7435.0 1153.0 1491.0 4849.0 4813.0 7348.0 6440.0 6912.0 6623.0 2132.0 Human Diseases; Infectious Diseases; Pertussis Phagosome 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Transport and Catabolism; Phagosome Phenylalanine metabolism 27468.0 31768.0 32701.0 33736.0 31320.0 30935.0 38334.0 36515.0 30430.0 34593.0 31362.0 29265.0 31111.0 33809.0 30817.0 33356.0 30259.0 27987.0 29294.0 32469.0 25252.0 25079.0 25867.0 32840.0 32536.0 27690.0 29825.0 32260.0 33743.0 37017.0 29296.0 37672.0 32066.0 32408.0 30617.0 34684.0 33090.0 30387.0 30796.0 20191.0 31518.0 34376.0 19827.0 24091.0 41515.0 38380.0 38730.0 24760.0 25802.0 25757.0 21912.0 Metabolism; Amino Acid Metabolism; Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis 120725.0 142671.0 138868.0 128977.0 128359.0 117703.0 154045.0 149581.0 122061.0 153908.0 129268.0 118165.0 115376.0 129725.0 156196.0 124131.0 116849.0 117452.0 126442.0 128049.0 117396.0 111681.0 121861.0 141725.0 131197.0 125567.0 123605.0 130764.0 157838.0 126681.0 109710.0 166845.0 129995.0 138126.0 117628.0 132089.0 151234.0 125391.0 128356.0 97477.0 142692.0 150734.0 95936.0 111001.0 139921.0 167787.0 123036.0 106898.0 106689.0 113681.0 110459.0 Metabolism; Amino Acid Metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis Phenylpropanoid biosynthesis 32815.0 25173.0 29073.0 22743.0 29878.0 43434.0 36680.0 36396.0 24349.0 35364.0 25106.0 34198.0 26199.0 23142.0 29037.0 22193.0 24017.0 41035.0 39761.0 39226.0 39120.0 21287.0 26073.0 36768.0 42832.0 38272.0 32268.0 37304.0 40962.0 27779.0 32002.0 32672.0 42487.0 32537.0 45028.0 28146.0 44692.0 35177.0 22255.0 15339.0 46675.0 38875.0 14289.0 16195.0 22157.0 45292.0 24132.0 37765.0 17957.0 48104.0 20698.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Phenylpropanoid biosynthesis Phosphatidylinositol signaling system 13686.0 16224.0 14866.0 13949.0 15816.0 16123.0 18734.0 17223.0 13604.0 16195.0 14380.0 13778.0 14824.0 15530.0 16819.0 14286.0 12390.0 13948.0 14388.0 13972.0 13536.0 11446.0 12597.0 15712.0 15406.0 13736.0 14943.0 14631.0 17876.0 17599.0 14016.0 17941.0 15271.0 15290.0 14443.0 16160.0 15793.0 15412.0 14373.0 8590.0 15329.0 14981.0 8773.0 10828.0 18388.0 17029.0 18089.0 12516.0 13975.0 14202.0 10433.0 Environmental Information Processing; Signal Transduction; Phosphatidylinositol signaling system Phosphonate and phosphinate metabolism 8213.0 10343.0 11840.0 10564.0 11513.0 6061.0 13344.0 14219.0 10692.0 12097.0 11283.0 10855.0 11529.0 13240.0 9549.0 12768.0 9791.0 8764.0 9017.0 9927.0 8285.0 9044.0 7268.0 11940.0 13061.0 11481.0 11028.0 10771.0 12752.0 14226.0 14197.0 18181.0 11729.0 10857.0 5550.0 11524.0 11623.0 12470.0 9046.0 4105.0 11492.0 12148.0 4240.0 5921.0 13859.0 16379.0 11592.0 7471.0 11270.0 7992.0 4583.0 Metabolism; Metabolism of Other Amino Acids; Phosphonate and phosphinate metabolism Phosphotransferase system (PTS) 61853.0 84025.0 116870.0 56526.0 32438.0 42909.0 62848.0 47403.0 44716.0 52361.0 32912.0 39167.0 31250.0 35555.0 68680.0 65994.0 30467.0 31646.0 36118.0 30080.0 34159.0 30367.0 33219.0 42538.0 43816.0 39056.0 30051.0 34289.0 63868.0 27476.0 26294.0 26291.0 35262.0 61294.0 34001.0 34160.0 60203.0 30939.0 23049.0 21184.0 40739.0 84852.0 30670.0 29747.0 52505.0 56688.0 54271.0 36225.0 49279.0 25071.0 42063.0 Environmental Information Processing; Membrane Transport; Phosphotransferase system (PTS) Photosynthesis 58101.0 73222.0 71565.0 49496.0 58244.0 52355.0 65287.0 66092.0 63895.0 76897.0 60193.0 51038.0 47820.0 63722.0 80802.0 60268.0 52193.0 48937.0 55412.0 51964.0 51881.0 54739.0 58188.0 73510.0 56556.0 57570.0 49724.0 55442.0 67126.0 49277.0 55071.0 51017.0 56799.0 65195.0 54874.0 64199.0 81695.0 53090.0 59979.0 53852.0 61889.0 71992.0 66561.0 63351.0 64509.0 65612.0 53475.0 47366.0 55933.0 49400.0 64931.0 Metabolism; Energy Metabolism; Photosynthesis Photosynthesis - antenna proteins 30.0 0.0 4.0 17.0 0.0 0.0 4.0 5.0 0.0 0.0 17.0 38.0 0.0 816.0 166.0 0.0 0.0 4.0 30.0 17.0 0.0 0.0 0.0 0.0 34.0 17.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 17.0 0.0 0.0 0.0 17.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 17.0 0.0 4.0 0.0 0.0 4.0 Metabolism; Energy Metabolism; Photosynthesis - antenna proteins Photosynthesis proteins 58975.0 75082.0 72056.0 50183.0 59098.0 52916.0 65796.0 67101.0 64652.0 78006.0 60795.0 51661.0 48341.0 65780.0 82425.0 61308.0 52847.0 49546.0 55909.0 52684.0 52162.0 54928.0 58440.0 74064.0 56998.0 58011.0 50299.0 56207.0 67434.0 50546.0 55299.0 51366.0 57282.0 66228.0 55198.0 64307.0 82018.0 53508.0 60227.0 54202.0 63537.0 72382.0 66827.0 63939.0 66926.0 66957.0 54070.0 47767.0 56618.0 50054.0 65305.0 Metabolism; Energy Metabolism; Photosynthesis proteins Phototransduction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Sensory System; Phototransduction Phototransduction - fly 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Sensory System; Phototransduction - fly Plant-pathogen interaction 21064.0 26629.0 27234.0 23327.0 22488.0 20342.0 28340.0 28907.0 22663.0 31943.0 22351.0 21778.0 16149.0 22918.0 33484.0 20397.0 18380.0 17550.0 21591.0 21354.0 20736.0 21488.0 23938.0 27364.0 21263.0 25452.0 20388.0 23205.0 29085.0 20006.0 19014.0 28061.0 24826.0 26050.0 19598.0 20662.0 31253.0 22815.0 23358.0 18144.0 28899.0 26272.0 19580.0 21047.0 26368.0 31838.0 18789.0 17371.0 17848.0 17372.0 21414.0 Organismal Systems; Environmental Adaptation; Plant-pathogen interaction Polycyclic aromatic hydrocarbon degradation 15276.0 17448.0 18763.0 13793.0 17187.0 15740.0 19590.0 19804.0 16879.0 20001.0 17203.0 15022.0 14497.0 17175.0 18336.0 14940.0 14486.0 14379.0 16550.0 15348.0 15697.0 15664.0 16259.0 19909.0 17242.0 17983.0 15711.0 15447.0 20140.0 16615.0 15637.0 20209.0 17106.0 17642.0 16714.0 18772.0 21701.0 16601.0 17548.0 13450.0 17114.0 18652.0 15861.0 15742.0 18087.0 19818.0 16668.0 13802.0 15201.0 14791.0 15905.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Polycyclic aromatic hydrocarbon degradation Polyketide sugar unit biosynthesis 29479.0 29336.0 37724.0 35725.0 33697.0 42744.0 43488.0 42797.0 34343.0 40314.0 35351.0 34860.0 34970.0 35472.0 36241.0 36654.0 30857.0 29333.0 31547.0 37451.0 28615.0 30543.0 36031.0 40520.0 42600.0 32889.0 33192.0 34794.0 43153.0 33528.0 37853.0 44923.0 40136.0 37910.0 46720.0 40652.0 42833.0 40804.0 31966.0 31101.0 35599.0 43497.0 33586.0 34264.0 32990.0 42410.0 37514.0 27030.0 34844.0 25607.0 33827.0 Metabolism; Metabolism of Terpenoids and Polyketides; Polyketide sugar unit biosynthesis Pores ion channels 62113.0 73504.0 66333.0 73706.0 75763.0 91814.0 85614.0 81715.0 69579.0 77152.0 77276.0 69549.0 84238.0 75611.0 75356.0 77818.0 71282.0 69530.0 66725.0 79927.0 59955.0 67633.0 67733.0 79728.0 88687.0 70858.0 76255.0 73857.0 84833.0 85250.0 89015.0 80851.0 82960.0 74810.0 90709.0 83057.0 74248.0 82201.0 76830.0 60160.0 65563.0 82573.0 55902.0 63454.0 74997.0 74408.0 90639.0 58194.0 72545.0 60093.0 63591.0 Unclassified; Cellular Processes and Signaling; Pores ion channels Porphyrin and chlorophyll metabolism 131361.0 174434.0 195966.0 144460.0 131531.0 101856.0 185156.0 172585.0 152479.0 186102.0 152333.0 131363.0 119975.0 150153.0 180289.0 138176.0 124027.0 110045.0 126111.0 134128.0 131363.0 138588.0 119091.0 179679.0 138094.0 145697.0 138756.0 137040.0 178294.0 145560.0 148302.0 140882.0 143062.0 149890.0 109384.0 140878.0 182116.0 139190.0 192094.0 84257.0 164043.0 156528.0 107256.0 103477.0 159955.0 170035.0 124594.0 109212.0 126952.0 94962.0 99007.0 Metabolism; Metabolism of Cofactors and Vitamins; Porphyrin and chlorophyll metabolism Prenyltransferases 46655.0 49030.0 49716.0 48302.0 49200.0 47497.0 58507.0 53810.0 47811.0 52955.0 51781.0 48299.0 46718.0 49375.0 51951.0 46365.0 47939.0 46383.0 51579.0 50660.0 47754.0 50143.0 53163.0 53268.0 51279.0 50491.0 50674.0 52110.0 57304.0 51067.0 47625.0 59090.0 51352.0 50095.0 47351.0 56508.0 55738.0 49759.0 55185.0 51967.0 49350.0 54169.0 51499.0 53925.0 48770.0 56255.0 55191.0 44911.0 42897.0 47536.0 55150.0 Metabolism; Metabolism of Terpenoids and Polyketides; Prenyltransferases Primary bile acid biosynthesis 5540.0 5651.0 8639.0 6577.0 7099.0 10191.0 9493.0 8564.0 6051.0 8812.0 6117.0 6693.0 6502.0 6531.0 7294.0 7255.0 5013.0 6634.0 5843.0 7682.0 5947.0 4217.0 5140.0 8146.0 9363.0 6767.0 6590.0 6441.0 9374.0 6611.0 9277.0 9430.0 8598.0 7736.0 10342.0 7433.0 8708.0 9142.0 4803.0 1943.0 7263.0 9297.0 2185.0 2829.0 6925.0 8773.0 8499.0 5156.0 6160.0 5616.0 3312.0 Metabolism; Lipid Metabolism; Primary bile acid biosynthesis Primary immunodeficiency 7788.0 7683.0 8993.0 6631.0 8621.0 7018.0 7562.0 8045.0 7096.0 8788.0 6409.0 6337.0 6914.0 6938.0 9149.0 7446.0 6212.0 7492.0 6784.0 6648.0 7283.0 4975.0 6660.0 8389.0 6662.0 6574.0 7626.0 7404.0 10895.0 7052.0 6788.0 6428.0 7427.0 8376.0 5271.0 5805.0 8517.0 6706.0 4497.0 6073.0 8270.0 7618.0 5684.0 7109.0 9840.0 9171.0 4949.0 7108.0 5192.0 8797.0 7508.0 Human Diseases; Immune System Diseases; Primary immunodeficiency Prion diseases 1020.0 1555.0 1977.0 739.0 792.0 571.0 535.0 1156.0 657.0 840.0 574.0 654.0 628.0 1014.0 1402.0 1449.0 664.0 594.0 427.0 403.0 303.0 243.0 290.0 392.0 394.0 408.0 417.0 921.0 409.0 1232.0 278.0 341.0 449.0 779.0 506.0 295.0 388.0 289.0 260.0 413.0 1625.0 582.0 282.0 667.0 2550.0 1340.0 788.0 412.0 825.0 582.0 337.0 Human Diseases; Neurodegenerative Diseases; Prion diseases Progesterone-mediated oocyte maturation 6229.0 6055.0 7120.0 6413.0 6452.0 7874.0 8023.0 7602.0 6384.0 7480.0 6472.0 6484.0 5467.0 6571.0 6760.0 5598.0 5362.0 5578.0 6351.0 7053.0 5976.0 6032.0 6675.0 6973.0 6712.0 6836.0 6193.0 6578.0 7968.0 6018.0 6003.0 8776.0 7117.0 6844.0 8603.0 7014.0 7699.0 6361.0 5266.0 6247.0 7260.0 6517.0 6714.0 6835.0 6425.0 7865.0 5939.0 5503.0 5102.0 5673.0 6674.0 Organismal Systems; Endocrine System; Progesterone-mediated oocyte maturation Propanoate metabolism 66248.0 79755.0 81866.0 70298.0 63412.0 75189.0 90091.0 74599.0 60721.0 76277.0 71676.0 62515.0 56584.0 67425.0 70254.0 66866.0 58906.0 57215.0 64510.0 65748.0 60617.0 63636.0 61197.0 67464.0 68071.0 65955.0 63841.0 62989.0 77484.0 70566.0 61676.0 83279.0 66583.0 70521.0 68433.0 66877.0 72854.0 61349.0 75374.0 49517.0 71166.0 81626.0 46558.0 53370.0 74992.0 85361.0 76289.0 52848.0 56873.0 51382.0 56071.0 Metabolism; Carbohydrate Metabolism; Propanoate metabolism Prostate cancer 6543.0 6239.0 7281.0 7009.0 6847.0 10360.0 8770.0 7988.0 6702.0 7894.0 6826.0 7284.0 6140.0 6850.0 6962.0 5845.0 5759.0 6174.0 6997.0 8178.0 6255.0 6760.0 7204.0 7414.0 7799.0 7446.0 7134.0 7350.0 8647.0 6482.0 6460.0 9224.0 8026.0 7608.0 11521.0 7546.0 8271.0 6969.0 6060.0 6349.0 7902.0 7203.0 6869.0 6927.0 6469.0 8438.0 6681.0 5767.0 5353.0 5876.0 6827.0 Human Diseases; Cancers; Prostate cancer Proteasome 6235.0 6155.0 7128.0 6425.0 6470.0 7891.0 8265.0 7652.0 6416.0 7500.0 6530.0 6512.0 5471.0 6581.0 6770.0 5607.0 5366.0 5584.0 6357.0 7107.0 5984.0 6082.0 6701.0 6975.0 6736.0 6917.0 6239.0 6626.0 7982.0 6578.0 6005.0 9099.0 7127.0 6846.0 8609.0 7250.0 7713.0 6393.0 5276.0 6263.0 7347.0 6519.0 6726.0 6859.0 6499.0 7867.0 5941.0 5509.0 5132.0 5682.0 6678.0 Genetic Information Processing; Folding, Sorting and Degradation; Proteasome Protein digestion and absorption 5218.0 3033.0 4758.0 6200.0 7291.0 6597.0 6609.0 7214.0 6442.0 5931.0 6351.0 5699.0 8214.0 6461.0 4571.0 7377.0 7010.0 6761.0 5000.0 7115.0 6028.0 6423.0 6733.0 7048.0 8293.0 5826.0 6824.0 6190.0 8128.0 7042.0 9310.0 7347.0 7756.0 5379.0 7171.0 7300.0 6289.0 8271.0 3558.0 8566.0 5081.0 7269.0 7627.0 7818.0 4853.0 5270.0 5478.0 6500.0 6784.0 7051.0 8408.0 Organismal Systems; Digestive System; Protein digestion and absorption Protein export 90543.0 102889.0 107326.0 94346.0 94866.0 91891.0 118434.0 108471.0 91232.0 108475.0 99158.0 89435.0 85134.0 98309.0 106859.0 92322.0 86121.0 85716.0 92233.0 90116.0 89539.0 91466.0 91474.0 102264.0 96426.0 95329.0 89830.0 93014.0 109631.0 97483.0 87644.0 116992.0 95193.0 99207.0 86575.0 95677.0 107675.0 93495.0 102365.0 79397.0 99393.0 105124.0 82288.0 88325.0 102354.0 114496.0 89620.0 82440.0 87216.0 85426.0 86956.0 Genetic Information Processing; Folding, Sorting and Degradation; Protein export Protein folding and associated processing 90688.0 107431.0 103355.0 101352.0 92988.0 92873.0 118564.0 113830.0 92376.0 109245.0 101715.0 94997.0 89553.0 102260.0 106879.0 99768.0 93809.0 84715.0 96415.0 98328.0 86211.0 94704.0 92345.0 104081.0 96938.0 93278.0 91988.0 100070.0 105503.0 110775.0 105091.0 114266.0 97151.0 101189.0 89472.0 109912.0 102033.0 93481.0 116765.0 85359.0 113257.0 100618.0 83643.0 92194.0 115003.0 118737.0 119188.0 79840.0 88371.0 80482.0 87555.0 Unclassified; Genetic Information Processing; Protein folding and associated processing Protein kinases 40737.0 51646.0 51973.0 38151.0 42546.0 37365.0 51656.0 56489.0 40002.0 53921.0 41804.0 39245.0 34924.0 44359.0 50586.0 44340.0 34426.0 32802.0 40941.0 38702.0 38362.0 36216.0 38046.0 47562.0 38823.0 42212.0 39954.0 38748.0 50737.0 44130.0 35191.0 50577.0 43182.0 47357.0 31526.0 43624.0 49925.0 43384.0 43673.0 26098.0 56494.0 47677.0 27580.0 32578.0 55583.0 60183.0 47018.0 30729.0 35820.0 33590.0 31232.0 Metabolism; Enzyme Families; Protein kinases Protein processing in endoplasmic reticulum 10598.0 9342.0 11906.0 15279.0 12571.0 14800.0 15509.0 14842.0 12323.0 14016.0 13401.0 13420.0 12383.0 13399.0 11330.0 12324.0 11148.0 11167.0 11480.0 13890.0 11198.0 12600.0 13106.0 13756.0 14853.0 13119.0 12278.0 13827.0 15127.0 13668.0 14365.0 18388.0 14984.0 12094.0 15787.0 14897.0 13628.0 15185.0 12905.0 11487.0 12580.0 13728.0 11161.0 11739.0 11104.0 13802.0 14507.0 11345.0 11967.0 10400.0 11712.0 Genetic Information Processing; Folding, Sorting and Degradation; Protein processing in endoplasmic reticulum Proximal tubule bicarbonate reclamation 2642.0 3350.0 5003.0 4754.0 4206.0 4492.0 6087.0 5648.0 4055.0 4881.0 5852.0 4507.0 5733.0 5246.0 3525.0 5023.0 4162.0 3278.0 4523.0 4648.0 2999.0 3710.0 3451.0 5032.0 6030.0 4110.0 4862.0 4096.0 4946.0 5746.0 5559.0 7495.0 5473.0 4350.0 4224.0 7406.0 4183.0 6235.0 6233.0 1071.0 2494.0 5616.0 1034.0 1715.0 3888.0 5136.0 9490.0 1942.0 4968.0 1509.0 1156.0 Organismal Systems; Excretory System; Proximal tubule bicarbonate reclamation Purine metabolism 316495.0 360189.0 386419.0 319245.0 322718.0 329194.0 410043.0 381152.0 313238.0 379092.0 346923.0 309605.0 296516.0 335597.0 372754.0 322758.0 314136.0 296879.0 321955.0 320315.0 313348.0 328997.0 334586.0 359936.0 337358.0 332037.0 317505.0 329209.0 379996.0 349370.0 307470.0 408991.0 332390.0 347492.0 309157.0 343036.0 371545.0 325743.0 375231.0 309707.0 363766.0 366717.0 310510.0 331018.0 359672.0 402540.0 335078.0 279216.0 301684.0 289878.0 330368.0 Metabolism; Nucleotide Metabolism; Purine metabolism Pyrimidine metabolism 261569.0 297118.0 329867.0 264673.0 264177.0 271216.0 335624.0 318051.0 262056.0 313431.0 288964.0 261147.0 240947.0 276977.0 306603.0 266206.0 261867.0 240866.0 263382.0 264476.0 262329.0 277822.0 285244.0 296566.0 278915.0 279863.0 263586.0 263358.0 316140.0 279665.0 257778.0 343281.0 275296.0 285982.0 253699.0 274621.0 316353.0 272949.0 305560.0 270512.0 297762.0 308108.0 276128.0 285888.0 287647.0 334200.0 254033.0 231473.0 254374.0 235803.0 286497.0 Metabolism; Nucleotide Metabolism; Pyrimidine metabolism Pyruvate metabolism 144545.0 168882.0 183865.0 148547.0 151842.0 164799.0 201191.0 185260.0 149007.0 174083.0 158802.0 145753.0 144631.0 157533.0 170975.0 156071.0 134583.0 133002.0 148236.0 157498.0 139020.0 131564.0 137946.0 169562.0 169798.0 155807.0 159929.0 146915.0 194459.0 155602.0 152932.0 210888.0 160029.0 167551.0 155334.0 170304.0 180922.0 159281.0 148891.0 100568.0 161516.0 186507.0 102807.0 112511.0 155268.0 201464.0 169231.0 119130.0 143873.0 121303.0 115580.0 Metabolism; Carbohydrate Metabolism; Pyruvate metabolism RIG-I-like receptor signaling pathway 143.0 447.0 188.0 34.0 114.0 40.0 30.0 135.0 90.0 106.0 70.0 148.0 17.0 76.0 159.0 366.0 57.0 132.0 66.0 36.0 36.0 77.0 86.0 95.0 185.0 58.0 166.0 36.0 150.0 69.0 19.0 56.0 91.0 105.0 74.0 85.0 374.0 33.0 49.0 34.0 76.0 937.0 76.0 120.0 140.0 149.0 41.0 39.0 489.0 100.0 400.0 Organismal Systems; Immune System; RIG-I-like receptor signaling pathway RNA degradation 72700.0 80580.0 86271.0 72010.0 77417.0 75830.0 90833.0 85175.0 74479.0 87538.0 80348.0 71093.0 71550.0 78453.0 84820.0 75418.0 68999.0 69179.0 75722.0 74428.0 72204.0 71110.0 72799.0 84422.0 79187.0 75512.0 74404.0 74903.0 88754.0 78433.0 74982.0 88061.0 78834.0 78457.0 74076.0 83809.0 87104.0 77142.0 82261.0 63366.0 77733.0 84312.0 65660.0 69373.0 78270.0 87083.0 81365.0 66135.0 69916.0 69583.0 70129.0 Genetic Information Processing; Folding, Sorting and Degradation; RNA degradation RNA polymerase 21178.0 25890.0 27008.0 22468.0 21618.0 23162.0 29384.0 25672.0 21230.0 26174.0 24512.0 21570.0 18928.0 23382.0 25787.0 21442.0 22050.0 19476.0 22470.0 21591.0 21171.0 24448.0 24382.0 24132.0 22053.0 24573.0 21896.0 21889.0 25279.0 24404.0 19616.0 29402.0 21780.0 23829.0 19715.0 23078.0 25588.0 21334.0 29241.0 21533.0 24273.0 25617.0 21292.0 22963.0 26292.0 28443.0 22933.0 18267.0 20255.0 17975.0 22752.0 Genetic Information Processing; Transcription; RNA polymerase RNA transport 19296.0 23537.0 22021.0 18856.0 18839.0 17210.0 24305.0 22463.0 17818.0 23482.0 17968.0 17421.0 13399.0 18011.0 24519.0 17134.0 14262.0 15946.0 18561.0 17634.0 18375.0 16508.0 17706.0 20658.0 18176.0 18858.0 18235.0 16960.0 24652.0 16575.0 13614.0 23106.0 18725.0 20909.0 15228.0 17324.0 23244.0 17958.0 18840.0 12517.0 22849.0 22232.0 12287.0 14831.0 21600.0 25837.0 15895.0 16377.0 15179.0 16971.0 15885.0 Genetic Information Processing; Translation; RNA transport Regulation of actin cytoskeleton 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Motility; Regulation of actin cytoskeleton Renal cell carcinoma 815.0 1878.0 361.0 800.0 1116.0 528.0 1193.0 639.0 508.0 1435.0 1830.0 656.0 1173.0 1592.0 1482.0 1328.0 1355.0 1107.0 1370.0 723.0 596.0 1353.0 585.0 858.0 527.0 488.0 474.0 1583.0 91.0 2059.0 1940.0 394.0 609.0 909.0 337.0 1349.0 416.0 375.0 2988.0 482.0 951.0 807.0 257.0 804.0 2073.0 1046.0 2584.0 291.0 805.0 548.0 368.0 Human Diseases; Cancers; Renal cell carcinoma Renin-angiotensin system 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 7.0 7.0 5.0 3.0 0.0 0.0 7.0 0.0 0.0 0.0 2.0 1.0 0.0 2.0 0.0 0.0 0.0 0.0 4.0 8.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 Organismal Systems; Endocrine System; Renin-angiotensin system Replication, recombination and repair proteins 104100.0 121000.0 139205.0 108031.0 95878.0 97916.0 131151.0 115175.0 99916.0 116896.0 113682.0 105544.0 84376.0 103608.0 112179.0 93091.0 90581.0 83729.0 107588.0 98710.0 99651.0 110055.0 106524.0 109423.0 95349.0 111756.0 101495.0 108255.0 112313.0 110541.0 89761.0 122483.0 102288.0 107501.0 90482.0 116793.0 116969.0 96235.0 136068.0 85249.0 113091.0 105947.0 86159.0 93528.0 117791.0 120194.0 124914.0 85949.0 88515.0 82209.0 90898.0 Unclassified; Genetic Information Processing; Replication, recombination and repair proteins Restriction enzyme 30740.0 31940.0 34518.0 36595.0 34963.0 36608.0 41187.0 39243.0 36257.0 39483.0 36617.0 34711.0 34613.0 35110.0 39029.0 33747.0 28376.0 31436.0 30890.0 33865.0 31912.0 31335.0 36456.0 40667.0 41707.0 35190.0 35045.0 33702.0 43493.0 31346.0 33935.0 44503.0 38997.0 36524.0 35522.0 36896.0 44547.0 41855.0 34671.0 26539.0 30014.0 42533.0 30317.0 30148.0 27023.0 37101.0 31982.0 31644.0 36287.0 28414.0 30811.0 Unclassified; Genetic Information Processing; Restriction enzyme Retinol metabolism 4246.0 5103.0 5310.0 6082.0 5230.0 2552.0 6936.0 7499.0 4279.0 6221.0 5351.0 3904.0 5103.0 6929.0 4972.0 6187.0 4737.0 4612.0 4106.0 3767.0 3808.0 4136.0 4740.0 4849.0 7016.0 3174.0 3075.0 4974.0 4420.0 5954.0 3913.0 9774.0 5749.0 4787.0 1219.0 5204.0 3909.0 7190.0 3723.0 4539.0 4767.0 6196.0 4345.0 5033.0 7064.0 6517.0 7439.0 4123.0 6566.0 4102.0 4572.0 Metabolism; Metabolism of Cofactors and Vitamins; Retinol metabolism Rheumatoid arthritis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Immune System Diseases; Rheumatoid arthritis Riboflavin metabolism 36007.0 44314.0 39654.0 36493.0 38050.0 35379.0 46799.0 41662.0 38433.0 44607.0 39609.0 34480.0 35311.0 39747.0 48086.0 38382.0 37706.0 33793.0 36833.0 35371.0 33572.0 38518.0 40778.0 43198.0 38093.0 36336.0 33578.0 38613.0 39272.0 38621.0 35798.0 37866.0 38444.0 40741.0 34422.0 41416.0 44521.0 36039.0 43805.0 39699.0 35998.0 41210.0 42418.0 43991.0 44430.0 40536.0 42905.0 31625.0 35181.0 33058.0 43249.0 Metabolism; Metabolism of Cofactors and Vitamins; Riboflavin metabolism Ribosome 323083.0 377119.0 393227.0 332553.0 334546.0 348949.0 427030.0 389564.0 331141.0 395198.0 371658.0 328583.0 301752.0 354668.0 386390.0 323835.0 336090.0 300304.0 337694.0 333423.0 326608.0 365723.0 370589.0 374605.0 344631.0 363406.0 333527.0 333902.0 390790.0 360194.0 319849.0 440108.0 342574.0 359911.0 317525.0 353964.0 396401.0 334943.0 412270.0 346822.0 359884.0 379298.0 354559.0 369304.0 367624.0 416982.0 322642.0 285733.0 311701.0 292857.0 365230.0 Genetic Information Processing; Translation; Ribosome Ribosome Biogenesis 194736.0 248250.0 238842.0 187250.0 197630.0 204224.0 254712.0 233014.0 193004.0 244148.0 216843.0 190124.0 168816.0 208181.0 256343.0 188377.0 188653.0 173165.0 199450.0 190455.0 189525.0 205847.0 208298.0 225103.0 200364.0 208244.0 190163.0 195181.0 230957.0 205842.0 180255.0 250708.0 201217.0 221618.0 188863.0 203917.0 242818.0 192524.0 241113.0 182674.0 218782.0 224603.0 195381.0 204771.0 227276.0 252714.0 197840.0 159320.0 185831.0 166841.0 201925.0 Genetic Information Processing; Translation; Ribosome Biogenesis Ribosome biogenesis in eukaryotes 6724.0 8738.0 7885.0 6764.0 7160.0 6921.0 8797.0 8019.0 6777.0 8340.0 7517.0 6472.0 6172.0 7619.0 8800.0 6906.0 6671.0 6176.0 6695.0 6503.0 6357.0 6988.0 7039.0 7530.0 6820.0 7084.0 6317.0 6889.0 7753.0 8148.0 6225.0 8762.0 6924.0 7468.0 6131.0 6960.0 7979.0 6490.0 7559.0 6618.0 7319.0 7597.0 6870.0 7502.0 9081.0 8506.0 6708.0 5587.0 6524.0 6041.0 7216.0 Genetic Information Processing; Translation; Ribosome biogenesis in eukaryotes Salivary secretion 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Digestive System; Salivary secretion Secondary bile acid biosynthesis 5507.0 5609.0 8116.0 6414.0 7083.0 10188.0 9488.0 8501.0 5992.0 8752.0 6097.0 6649.0 6421.0 6479.0 7257.0 6957.0 4806.0 6585.0 5823.0 7653.0 5927.0 4162.0 5115.0 8128.0 9291.0 6749.0 6530.0 6400.0 9355.0 6587.0 9222.0 9410.0 8556.0 7692.0 10333.0 7384.0 8675.0 9103.0 4793.0 1916.0 7212.0 9128.0 2156.0 2807.0 6364.0 8624.0 7826.0 5119.0 6137.0 5586.0 3302.0 Metabolism; Lipid Metabolism; Secondary bile acid biosynthesis Secretion system 168017.0 206121.0 190205.0 173003.0 155973.0 161749.0 208321.0 194754.0 150781.0 202200.0 170892.0 152565.0 127695.0 161132.0 209705.0 144899.0 137813.0 126917.0 163665.0 148720.0 144668.0 147899.0 158955.0 171272.0 135285.0 156054.0 146898.0 155996.0 176495.0 160342.0 121223.0 183906.0 158622.0 182259.0 126421.0 159021.0 186978.0 146006.0 187909.0 122540.0 194248.0 164292.0 121014.0 139977.0 198673.0 208990.0 192771.0 125163.0 126801.0 130353.0 135349.0 Environmental Information Processing; Membrane Transport; Secretion system Selenocompound metabolism 52462.0 63409.0 65990.0 51556.0 53183.0 54625.0 66276.0 64201.0 53885.0 64530.0 54884.0 51419.0 50982.0 55423.0 64820.0 55674.0 50229.0 48972.0 53672.0 54892.0 49997.0 50450.0 53930.0 61383.0 57757.0 55068.0 53525.0 55981.0 65545.0 55306.0 50146.0 63633.0 56037.0 60013.0 52600.0 59842.0 64316.0 55879.0 58278.0 44846.0 60967.0 65693.0 46912.0 49940.0 61459.0 69447.0 62113.0 44236.0 50515.0 45700.0 50422.0 Metabolism; Metabolism of Other Amino Acids; Selenocompound metabolism Sesquiterpenoid biosynthesis 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Metabolism; Metabolism of Terpenoids and Polyketides; Sesquiterpenoid biosynthesis Shigellosis 2.0 2.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Infectious Diseases; Shigellosis Signal transduction mechanisms 65689.0 80858.0 85424.0 52030.0 58270.0 58360.0 85889.0 73337.0 60907.0 74591.0 65680.0 57955.0 47852.0 61562.0 77000.0 56436.0 48217.0 49156.0 65340.0 57378.0 58812.0 57489.0 56602.0 68519.0 58812.0 63225.0 57837.0 58572.0 75843.0 55727.0 56497.0 75414.0 59293.0 68868.0 55420.0 70334.0 78071.0 55637.0 69332.0 44268.0 70128.0 70310.0 53240.0 51954.0 63410.0 76549.0 70354.0 47233.0 56016.0 49286.0 52547.0 Unclassified; Cellular Processes and Signaling; Signal transduction mechanisms Small cell lung cancer 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 13.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Human Diseases; Cancers; Small cell lung cancer Sphingolipid metabolism 49524.0 40687.0 58482.0 51982.0 55031.0 77226.0 68634.0 68110.0 51888.0 61327.0 49420.0 53483.0 58004.0 50840.0 52105.0 54303.0 43326.0 59250.0 55614.0 64059.0 51988.0 38070.0 45100.0 64572.0 77368.0 57309.0 52539.0 56881.0 73439.0 51726.0 63282.0 63370.0 70209.0 56011.0 85138.0 64291.0 68995.0 67681.0 37715.0 30309.0 67553.0 67812.0 33385.0 33610.0 45078.0 65479.0 65642.0 54480.0 52044.0 55760.0 36062.0 Metabolism; Lipid Metabolism; Sphingolipid metabolism Spliceosome 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Genetic Information Processing; Transcription; Spliceosome Sporulation 82839.0 115024.0 143677.0 63284.0 75362.0 58100.0 122062.0 111429.0 78013.0 122062.0 80195.0 72004.0 41017.0 81804.0 119711.0 73297.0 59353.0 47519.0 75490.0 69837.0 82252.0 82761.0 84981.0 99515.0 74845.0 95410.0 82578.0 61014.0 122178.0 57184.0 50695.0 133751.0 80952.0 104440.0 54894.0 64982.0 125347.0 76555.0 91403.0 54317.0 104627.0 107303.0 65276.0 66457.0 73052.0 143617.0 38000.0 45381.0 57042.0 46904.0 70038.0 Unclassified; Cellular Processes and Signaling; Sporulation Staphylococcus aureus infection 354.0 176.0 295.0 36.0 92.0 62.0 55.0 122.0 19.0 65.0 78.0 78.0 53.0 32.0 146.0 24.0 68.0 82.0 108.0 106.0 85.0 45.0 57.0 60.0 93.0 53.0 308.0 71.0 54.0 297.0 27.0 75.0 52.0 62.0 182.0 69.0 196.0 33.0 65.0 73.0 61.0 74.0 29.0 32.0 121.0 71.0 44.0 20.0 1503.0 29.0 34.0 Human Diseases; Infectious Diseases; Staphylococcus aureus infection Starch and sucrose metabolism 163546.0 165637.0 196543.0 153270.0 163931.0 197293.0 211400.0 204044.0 159794.0 194737.0 155781.0 166187.0 149885.0 155689.0 183710.0 148998.0 138899.0 163267.0 172043.0 178380.0 168554.0 134379.0 153951.0 199886.0 204416.0 177971.0 169566.0 172427.0 223556.0 152624.0 173056.0 221669.0 192944.0 187687.0 208431.0 173691.0 225263.0 178067.0 141026.0 118345.0 203284.0 201436.0 131469.0 130736.0 142485.0 229777.0 156453.0 155346.0 143079.0 170253.0 139730.0 Metabolism; Carbohydrate Metabolism; Starch and sucrose metabolism Steroid biosynthesis 7.0 18.0 0.0 11.0 24.0 126.0 70.0 72.0 3.0 3.0 242.0 131.0 0.0 101.0 20.0 1.0 5.0 4.0 1458.0 6.0 7.0 78.0 397.0 0.0 5.0 72.0 6.0 415.0 1.0 0.0 0.0 3.0 3.0 94.0 0.0 2785.0 1.0 152.0 1702.0 1.0 3.0 3.0 7.0 3.0 2.0 2.0 5046.0 3.0 1.0 14.0 42.0 Metabolism; Lipid Metabolism; Steroid biosynthesis Steroid hormone biosynthesis 4771.0 2249.0 2572.0 4887.0 5432.0 13221.0 5534.0 5448.0 4750.0 4407.0 4379.0 6369.0 6960.0 4220.0 2509.0 4463.0 4097.0 7777.0 8201.0 9047.0 5440.0 4348.0 5451.0 6097.0 8996.0 6697.0 6952.0 7124.0 7501.0 6197.0 8046.0 6072.0 7640.0 5357.0 15206.0 11143.0 6628.0 6242.0 6167.0 3827.0 7070.0 6261.0 4196.0 4216.0 2460.0 5951.0 14343.0 6481.0 3650.0 6838.0 4848.0 Metabolism; Lipid Metabolism; Steroid hormone biosynthesis Stilbenoid, diarylheptanoid and gingerol biosynthesis 24.0 9.0 481.0 31.0 20.0 13.0 33.0 64.0 10.0 3.0 102.0 97.0 21.0 108.0 41.0 2.0 122.0 9.0 93.0 122.0 74.0 135.0 113.0 11.0 43.0 147.0 14.0 7.0 4.0 92.0 27.0 128.0 114.0 12.0 33.0 35.0 55.0 199.0 54.0 10.0 17.0 5.0 19.0 19.0 560.0 14.0 561.0 19.0 5.0 66.0 29.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Stilbenoid, diarylheptanoid and gingerol biosynthesis Streptomycin biosynthesis 46752.0 47125.0 55573.0 53891.0 52257.0 65855.0 63304.0 65065.0 52218.0 59481.0 52740.0 53952.0 53089.0 53269.0 53273.0 53545.0 47370.0 46865.0 50864.0 57708.0 46853.0 46103.0 53106.0 61239.0 64287.0 51564.0 54886.0 53769.0 67791.0 53056.0 57893.0 72550.0 60345.0 58087.0 71235.0 63007.0 65443.0 60488.0 49235.0 45677.0 58325.0 65926.0 47886.0 49168.0 47565.0 67127.0 59890.0 43655.0 50668.0 44334.0 50675.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Streptomycin biosynthesis Styrene degradation 1963.0 4002.0 3020.0 2196.0 1555.0 2016.0 3430.0 2364.0 1717.0 1871.0 1572.0 1765.0 3635.0 2084.0 1736.0 3800.0 3527.0 2193.0 3153.0 2839.0 1528.0 854.0 1993.0 1720.0 2038.0 1222.0 2102.0 4083.0 2747.0 2434.0 914.0 1197.0 1809.0 2781.0 1595.0 3584.0 1456.0 1453.0 1916.0 1377.0 3240.0 3632.0 1023.0 2081.0 4808.0 4386.0 7164.0 1076.0 807.0 1304.0 1489.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Styrene degradation Sulfur metabolism 43212.0 50448.0 45402.0 40770.0 49383.0 47302.0 52469.0 53022.0 45908.0 55227.0 43618.0 43162.0 44750.0 46130.0 57189.0 46600.0 39137.0 43572.0 48749.0 47857.0 41618.0 36419.0 42914.0 54115.0 50271.0 46355.0 46678.0 50702.0 59585.0 44398.0 42626.0 50788.0 51069.0 51055.0 48057.0 55163.0 58227.0 48546.0 40241.0 31178.0 50289.0 57845.0 33540.0 37738.0 50382.0 57371.0 59107.0 37634.0 40176.0 42352.0 39942.0 Metabolism; Energy Metabolism; Sulfur metabolism Sulfur relay system 38752.0 55162.0 51784.0 32484.0 36316.0 37653.0 53846.0 43844.0 37275.0 45086.0 35064.0 32329.0 31542.0 38761.0 56717.0 36914.0 26829.0 30493.0 36207.0 31856.0 30402.0 23583.0 29879.0 41065.0 37160.0 31146.0 31568.0 35247.0 43223.0 33003.0 25922.0 39994.0 35517.0 44018.0 33050.0 42316.0 45967.0 33018.0 31914.0 18162.0 35822.0 42663.0 25409.0 27556.0 47689.0 44551.0 49134.0 26596.0 37262.0 28629.0 26223.0 Genetic Information Processing; Folding, Sorting and Degradation; Sulfur relay system Synthesis and degradation of ketone bodies 3445.0 4885.0 4662.0 2213.0 2853.0 2318.0 5148.0 4409.0 3576.0 5404.0 3295.0 2680.0 3004.0 3062.0 6530.0 3357.0 3550.0 2476.0 4374.0 3264.0 3556.0 3277.0 3622.0 4662.0 2459.0 3984.0 3182.0 4369.0 4780.0 2490.0 2465.0 2809.0 3539.0 4457.0 2793.0 3613.0 5833.0 2641.0 4815.0 2136.0 4972.0 4987.0 3240.0 3317.0 4258.0 5926.0 4879.0 1750.0 2618.0 1382.0 3104.0 Metabolism; Lipid Metabolism; Synthesis and degradation of ketone bodies Systemic lupus erythematosus 2.0 8.0 0.0 3.0 8.0 42.0 23.0 24.0 1.0 1.0 80.0 42.0 0.0 2.0 3.0 0.0 2.0 1.0 485.0 1.0 3.0 26.0 132.0 0.0 0.0 24.0 2.0 138.0 0.0 0.0 0.0 1.0 1.0 30.0 0.0 928.0 0.0 50.0 567.0 0.0 1.0 0.0 2.0 2.0 0.0 0.0 1683.0 0.0 0.0 5.0 14.0 Human Diseases; Immune System Diseases; Systemic lupus erythematosus TGF-beta signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; TGF-beta signaling pathway Taurine and hypotaurine metabolism 15163.0 16461.0 19311.0 16032.0 16880.0 20701.0 21031.0 20986.0 17679.0 18299.0 17199.0 17439.0 19516.0 16824.0 17830.0 18291.0 16733.0 14881.0 17547.0 20328.0 14255.0 14942.0 18177.0 19287.0 20020.0 18705.0 19636.0 19020.0 22074.0 16657.0 19402.0 20639.0 19379.0 18377.0 20057.0 22178.0 21007.0 19423.0 15156.0 14370.0 17867.0 21298.0 14555.0 15596.0 16151.0 20213.0 21064.0 12725.0 15982.0 13154.0 15247.0 Metabolism; Metabolism of Other Amino Acids; Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis 80778.0 91255.0 96551.0 80802.0 83062.0 76491.0 104636.0 95217.0 81758.0 97994.0 89174.0 79921.0 75097.0 84416.0 97998.0 80762.0 82032.0 75355.0 85998.0 82536.0 81990.0 88293.0 90874.0 93398.0 84621.0 88834.0 82668.0 83673.0 100342.0 83305.0 77441.0 103683.0 85443.0 89259.0 78417.0 89064.0 101983.0 82806.0 97586.0 84152.0 87479.0 97934.0 86831.0 90677.0 84799.0 102422.0 82321.0 71642.0 74354.0 73228.0 91573.0 Metabolism; Metabolism of Terpenoids and Polyketides; Terpenoid backbone biosynthesis Tetracycline biosynthesis 18085.0 23085.0 24438.0 17555.0 17745.0 20179.0 25603.0 20361.0 16061.0 20037.0 17711.0 15506.0 13103.0 19264.0 20280.0 19131.0 11242.0 15499.0 16581.0 16513.0 15576.0 13276.0 12381.0 17415.0 20170.0 17553.0 16052.0 14635.0 22023.0 19563.0 16797.0 26947.0 17410.0 20431.0 19887.0 18303.0 19557.0 15533.0 13973.0 7491.0 14930.0 21981.0 8136.0 10978.0 24298.0 24086.0 20804.0 13432.0 16821.0 12828.0 11162.0 Metabolism; Metabolism of Terpenoids and Polyketides; Tetracycline biosynthesis Thiamine metabolism 74624.0 86681.0 91511.0 74821.0 76885.0 72691.0 95941.0 91441.0 76912.0 95016.0 79042.0 72298.0 69752.0 78513.0 94100.0 75428.0 68497.0 68986.0 77312.0 77025.0 72823.0 71435.0 77029.0 89027.0 79674.0 80556.0 72505.0 77749.0 94422.0 74259.0 68918.0 90923.0 79989.0 82733.0 72326.0 82160.0 99182.0 77261.0 83470.0 57890.0 84509.0 94456.0 65184.0 69490.0 85513.0 95446.0 76419.0 65663.0 68273.0 66528.0 69446.0 Metabolism; Metabolism of Cofactors and Vitamins; Thiamine metabolism Tight junction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Cellular Processes; Cell Communication; Tight junction Toluene degradation 19993.0 29447.0 16023.0 26428.0 34161.0 14876.0 15373.0 24022.0 26365.0 27457.0 20495.0 23228.0 24949.0 39797.0 23435.0 35221.0 20051.0 24197.0 18304.0 16128.0 12268.0 12254.0 14615.0 19348.0 14270.0 12254.0 16488.0 30116.0 14293.0 46803.0 18078.0 16502.0 20845.0 23230.0 15685.0 19742.0 16084.0 15289.0 11510.0 16088.0 19510.0 16611.0 20365.0 30889.0 78922.0 25363.0 28013.0 18100.0 21501.0 26323.0 21542.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Toluene degradation Toxoplasmosis 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 13.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Human Diseases; Infectious Diseases; Toxoplasmosis Transcription factors 220640.0 287250.0 311781.0 200723.0 196414.0 208468.0 295107.0 276062.0 206555.0 267764.0 210370.0 204075.0 167195.0 210714.0 272804.0 215325.0 179168.0 163771.0 210822.0 203025.0 199538.0 196499.0 204937.0 241850.0 209017.0 227990.0 209067.0 195838.0 274197.0 199572.0 179639.0 280106.0 213738.0 255397.0 195707.0 208871.0 274630.0 200597.0 218891.0 158790.0 275271.0 259763.0 181003.0 184926.0 224364.0 316768.0 201170.0 155556.0 185918.0 154159.0 184961.0 Genetic Information Processing; Transcription; Transcription factors Transcription machinery 149895.0 160093.0 180261.0 146580.0 162865.0 186037.0 196559.0 189953.0 153669.0 189162.0 166084.0 153740.0 148466.0 162414.0 176736.0 157946.0 138992.0 145050.0 162280.0 168331.0 153503.0 153299.0 160601.0 180446.0 179491.0 167020.0 165545.0 156318.0 203855.0 158479.0 167655.0 191967.0 179144.0 171731.0 191387.0 183800.0 195053.0 172767.0 166053.0 131407.0 174306.0 188126.0 137799.0 143425.0 154994.0 193923.0 182460.0 131560.0 146715.0 136087.0 147152.0 Genetic Information Processing; Transcription; Transcription machinery Transcription related proteins 696.0 935.0 2070.0 449.0 118.0 650.0 662.0 408.0 167.0 220.0 479.0 421.0 365.0 225.0 363.0 661.0 349.0 188.0 913.0 1017.0 208.0 340.0 373.0 253.0 703.0 201.0 688.0 906.0 247.0 365.0 171.0 452.0 421.0 344.0 450.0 978.0 424.0 325.0 881.0 95.0 380.0 1139.0 83.0 125.0 621.0 286.0 2483.0 107.0 285.0 327.0 433.0 Unclassified; Genetic Information Processing; Transcription related proteins Translation factors 76273.0 87743.0 91969.0 77091.0 78139.0 81563.0 101719.0 91740.0 77762.0 91332.0 86642.0 77394.0 72326.0 82145.0 89897.0 76058.0 77641.0 71249.0 80371.0 78727.0 76495.0 83994.0 85002.0 87698.0 81745.0 85102.0 78565.0 79453.0 92506.0 83379.0 76000.0 100135.0 80836.0 83936.0 75949.0 85098.0 92667.0 78856.0 95938.0 78555.0 85271.0 89257.0 80260.0 83484.0 84546.0 96056.0 78854.0 67481.0 72985.0 69346.0 82805.0 Genetic Information Processing; Translation; Translation factors Translation proteins 126746.0 156020.0 159099.0 130932.0 127215.0 128416.0 171376.0 152956.0 125913.0 155116.0 143234.0 126437.0 115251.0 136377.0 157724.0 125019.0 126065.0 113324.0 132032.0 127624.0 123938.0 135743.0 136844.0 142835.0 132499.0 138537.0 127916.0 129631.0 152658.0 136620.0 119100.0 171171.0 131275.0 143080.0 120219.0 134528.0 152737.0 127425.0 159090.0 122262.0 143220.0 147545.0 124762.0 132927.0 145389.0 166688.0 133595.0 106512.0 119360.0 107848.0 129845.0 Unclassified; Genetic Information Processing; Translation proteins Transporters 833924.0 1194323.0 1217586.0 834324.0 794088.0 763531.0 1043543.0 1123810.0 843399.0 1121008.0 865636.0 802517.0 660059.0 884509.0 1102010.0 916277.0 743977.0 654826.0 814592.0 812767.0 784345.0 781027.0 764539.0 981279.0 820682.0 910677.0 803538.0 768544.0 1062011.0 856782.0 708799.0 992038.0 843711.0 1015107.0 714786.0 820896.0 1056396.0 825046.0 939253.0 576780.0 1193964.0 1033736.0 628277.0 675734.0 1123333.0 1267059.0 847961.0 627712.0 775177.0 607219.0 645107.0 Environmental Information Processing; Membrane Transport; Transporters Tropane, piperidine and pyridine alkaloid biosynthesis 19171.0 19983.0 19731.0 20372.0 19436.0 19381.0 22124.0 21022.0 18143.0 21511.0 19496.0 18821.0 18441.0 19040.0 20974.0 18405.0 18953.0 19533.0 20151.0 20320.0 18499.0 17026.0 17956.0 20457.0 19757.0 19218.0 19170.0 22043.0 22293.0 20352.0 17759.0 22858.0 20140.0 19755.0 19974.0 19257.0 22508.0 18355.0 18962.0 15830.0 20934.0 22050.0 15171.0 17466.0 20841.0 22769.0 19358.0 18201.0 15180.0 19146.0 17336.0 Metabolism; Biosynthesis of Other Secondary Metabolites; Tropane, piperidine and pyridine alkaloid biosynthesis Tryptophan metabolism 17870.0 22718.0 20399.0 14621.0 13939.0 21522.0 22308.0 18385.0 14364.0 17950.0 19017.0 16300.0 14702.0 15358.0 16556.0 16055.0 14894.0 14002.0 19809.0 16937.0 14565.0 14529.0 15425.0 16078.0 14276.0 15901.0 15546.0 18426.0 15749.0 17594.0 13143.0 14995.0 15600.0 18348.0 16822.0 20239.0 17048.0 13676.0 23070.0 11217.0 20972.0 18698.0 11378.0 13110.0 20348.0 21127.0 28339.0 12067.0 11484.0 12675.0 12919.0 Metabolism; Amino Acid Metabolism; Tryptophan metabolism Tuberculosis 21244.0 24818.0 27068.0 20455.0 22619.0 21757.0 28136.0 27034.0 22195.0 28349.0 24684.0 21872.0 20004.0 24458.0 27093.0 21890.0 21204.0 19137.0 23346.0 22132.0 20716.0 22397.0 23432.0 26450.0 24078.0 23536.0 21060.0 22928.0 26907.0 23103.0 21660.0 28978.0 24163.0 24410.0 22817.0 26538.0 29474.0 23332.0 25801.0 20404.0 23653.0 27108.0 22655.0 23218.0 24135.0 27755.0 26819.0 17343.0 21502.0 18352.0 23216.0 Human Diseases; Infectious Diseases; Tuberculosis Two-component system 200587.0 258186.0 246490.0 208530.0 224406.0 199395.0 234508.0 269872.0 205724.0 285670.0 202549.0 197232.0 180642.0 231753.0 274368.0 222714.0 174223.0 172114.0 208277.0 202908.0 183900.0 166195.0 189270.0 235880.0 182231.0 201509.0 200605.0 218558.0 239255.0 231797.0 167101.0 223186.0 223460.0 247763.0 182603.0 204308.0 249192.0 204909.0 208897.0 125926.0 279214.0 229031.0 131867.0 167488.0 329651.0 299811.0 250198.0 151886.0 162179.0 177536.0 154028.0 Environmental Information Processing; Signal Transduction; Two-component system Type I diabetes mellitus 7681.0 8525.0 9477.0 8729.0 8867.0 9460.0 11285.0 10450.0 8936.0 9996.0 9800.0 9161.0 9127.0 9289.0 9263.0 8864.0 8239.0 7394.0 8210.0 9488.0 7594.0 8435.0 8682.0 10134.0 9927.0 9486.0 9606.0 8685.0 11001.0 9591.0 9584.0 11490.0 9808.0 9468.0 9519.0 9841.0 10439.0 9785.0 9372.0 6920.0 8438.0 10276.0 7208.0 7747.0 8719.0 10472.0 8541.0 6547.0 8330.0 6647.0 7585.0 Human Diseases; Metabolic Diseases; Type I diabetes mellitus Type II diabetes mellitus 6723.0 7156.0 8192.0 8150.0 6015.0 9457.0 9003.0 8038.0 6476.0 7176.0 6652.0 6899.0 5928.0 6333.0 7520.0 5726.0 6319.0 6202.0 6611.0 7100.0 6017.0 6189.0 7420.0 6992.0 7874.0 6965.0 6657.0 8149.0 8113.0 6011.0 6037.0 11137.0 6927.0 7521.0 9059.0 7204.0 8177.0 6717.0 6038.0 6804.0 8005.0 7969.0 6703.0 6774.0 5126.0 9157.0 6905.0 6071.0 6065.0 5438.0 6970.0 Human Diseases; Metabolic Diseases; Type II diabetes mellitus Tyrosine metabolism 48856.0 52579.0 58365.0 49143.0 48079.0 48825.0 64447.0 58801.0 46077.0 55100.0 51666.0 47142.0 45058.0 50523.0 50751.0 47565.0 44552.0 44718.0 49379.0 47796.0 46186.0 43776.0 45605.0 52143.0 52537.0 48872.0 47277.0 48875.0 57611.0 52409.0 45703.0 67864.0 50855.0 51375.0 45780.0 52769.0 55627.0 50261.0 48651.0 37645.0 51218.0 55609.0 38978.0 41907.0 54055.0 61901.0 57281.0 42412.0 43967.0 43862.0 41837.0 Metabolism; Amino Acid Metabolism; Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis 31168.0 29983.0 26348.0 31949.0 30900.0 35450.0 34378.0 33568.0 26365.0 27551.0 30950.0 29638.0 31715.0 29549.0 30650.0 31017.0 30724.0 33465.0 31084.0 30739.0 27345.0 27229.0 32748.0 26779.0 31654.0 24338.0 26689.0 32508.0 30572.0 33480.0 32891.0 30666.0 31547.0 27090.0 31322.0 38482.0 26797.0 31645.0 25296.0 38656.0 30383.0 32115.0 35037.0 38529.0 32596.0 27407.0 47138.0 30824.0 28595.0 35296.0 39973.0 Metabolism; Metabolism of Cofactors and Vitamins; Ubiquinone and other terpenoid-quinone biosynthesis Ubiquitin system 2345.0 2026.0 1876.0 2048.0 2529.0 3222.0 2587.0 2588.0 2298.0 2037.0 1924.0 1722.0 2887.0 2163.0 2398.0 2289.0 1448.0 2726.0 2319.0 2337.0 2311.0 795.0 1232.0 2287.0 2682.0 1496.0 2149.0 1771.0 2549.0 2455.0 1635.0 2445.0 2285.0 2077.0 3195.0 3762.0 1884.0 2505.0 1399.0 295.0 2085.0 2388.0 392.0 629.0 1704.0 1281.0 3787.0 2730.0 2710.0 2928.0 746.0 Genetic Information Processing; Folding, Sorting and Degradation; Ubiquitin system VEGF signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; VEGF signaling pathway Valine, leucine and isoleucine biosynthesis 103113.0 124987.0 122375.0 106632.0 104000.0 102887.0 140696.0 129535.0 105658.0 124744.0 106897.0 104405.0 94756.0 107912.0 131692.0 107117.0 90168.0 94035.0 109385.0 104682.0 98497.0 85200.0 97107.0 118099.0 110821.0 108521.0 103951.0 105534.0 130596.0 102636.0 95691.0 142284.0 107714.0 118780.0 97520.0 121326.0 130402.0 107004.0 103468.0 64965.0 120959.0 129475.0 72039.0 79622.0 112645.0 142078.0 116205.0 87915.0 99103.0 88582.0 77657.0 Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation 31135.0 38003.0 35642.0 36454.0 30770.0 35969.0 38220.0 37849.0 33302.0 38159.0 35345.0 31454.0 32546.0 32671.0 36846.0 34164.0 31493.0 28799.0 32951.0 34009.0 28320.0 29888.0 29560.0 36570.0 32544.0 30590.0 32434.0 37024.0 34475.0 36017.0 33927.0 33864.0 33591.0 34727.0 35804.0 38137.0 37725.0 30562.0 40400.0 24329.0 38429.0 40289.0 25490.0 27441.0 34190.0 39028.0 43918.0 26387.0 29123.0 24410.0 28073.0 Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine degradation Various types of N-glycan biosynthesis 12.0 1.0 0.0 1.0 1.0 2.0 1.0 8.0 0.0 0.0 3.0 1.0 0.0 0.0 8.0 0.0 0.0 9.0 1.0 2.0 1.0 12.0 0.0 1.0 1.0 2.0 2.0 112.0 0.0 1.0 0.0 81.0 4.0 0.0 113.0 0.0 1.0 3.0 1.0 0.0 32.0 0.0 0.0 1.0 3.0 0.0 0.0 0.0 1.0 1.0 1.0 Metabolism; Glycan Biosynthesis and Metabolism; Various types of N-glycan biosynthesis Vascular smooth muscle contraction 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Circulatory System; Vascular smooth muscle contraction Vasopressin-regulated water reabsorption 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Organismal Systems; Excretory System; Vasopressin-regulated water reabsorption Vibrio cholerae infection 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Human Diseases; Infectious Diseases; Vibrio cholerae infection Vibrio cholerae pathogenic cycle 11646.0 12999.0 15483.0 10966.0 10133.0 9014.0 11998.0 13101.0 10469.0 11809.0 10319.0 9838.0 10510.0 10111.0 14017.0 11258.0 10580.0 9348.0 9905.0 9978.0 10074.0 8073.0 10737.0 11680.0 10651.0 8582.0 9869.0 10417.0 13338.0 9298.0 8677.0 12246.0 10770.0 12362.0 8025.0 10305.0 12858.0 10153.0 7033.0 11775.0 11281.0 12552.0 12082.0 12270.0 10353.0 13663.0 9645.0 9455.0 9813.0 10160.0 12740.0 Human Diseases; Infectious Diseases; Vibrio cholerae pathogenic cycle Viral myocarditis 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 13.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Human Diseases; Cardiovascular Diseases; Viral myocarditis Vitamin B6 metabolism 31227.0 34795.0 35455.0 37207.0 33800.0 33566.0 39738.0 39531.0 33544.0 37831.0 34684.0 33455.0 32568.0 35503.0 35742.0 34357.0 31747.0 29581.0 30375.0 33308.0 29016.0 30808.0 32969.0 36518.0 36011.0 32535.0 32449.0 33514.0 39715.0 37480.0 34603.0 43875.0 35566.0 35039.0 34203.0 34274.0 38625.0 34448.0 31997.0 30691.0 34026.0 38235.0 31393.0 33439.0 35905.0 41792.0 32044.0 28566.0 31103.0 28621.0 33409.0 Metabolism; Metabolism of Cofactors and Vitamins; Vitamin B6 metabolism Wnt signaling pathway 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; Wnt signaling pathway Xylene degradation 4279.0 5442.0 7801.0 4329.0 3361.0 3979.0 6971.0 6727.0 3389.0 5064.0 4656.0 3995.0 2323.0 4280.0 5083.0 3864.0 3577.0 2631.0 3463.0 4511.0 4403.0 4649.0 4403.0 4430.0 4314.0 5370.0 4738.0 3112.0 6588.0 5429.0 2466.0 11378.0 4044.0 5631.0 2865.0 3296.0 4600.0 4213.0 4942.0 2731.0 5966.0 4486.0 2058.0 2911.0 5139.0 9370.0 2446.0 2257.0 3024.0 1847.0 2589.0 Metabolism; Xenobiotics Biodegradation and Metabolism; Xylene degradation Zeatin biosynthesis 8526.0 8403.0 9259.0 8667.0 9374.0 8974.0 10784.0 10292.0 8901.0 9972.0 9402.0 8737.0 9074.0 9233.0 9263.0 8850.0 9492.0 8765.0 8865.0 9461.0 8943.0 9666.0 9874.0 10125.0 9937.0 9249.0 9353.0 9162.0 10996.0 9568.0 9560.0 11377.0 9730.0 9199.0 9472.0 9799.0 10406.0 9439.0 9399.0 10690.0 9289.0 10241.0 10390.0 10762.0 8698.0 10376.0 8402.0 8379.0 8312.0 8993.0 11078.0 Metabolism; Metabolism of Terpenoids and Polyketides; Zeatin biosynthesis alpha-Linolenic acid metabolism 988.0 1019.0 738.0 378.0 346.0 1062.0 1306.0 417.0 358.0 204.0 683.0 463.0 496.0 255.0 84.0 434.0 287.0 184.0 353.0 275.0 375.0 529.0 169.0 158.0 111.0 268.0 743.0 246.0 412.0 366.0 1448.0 159.0 265.0 482.0 452.0 247.0 184.0 151.0 218.0 169.0 277.0 116.0 105.0 110.0 61.0 798.0 556.0 100.0 76.0 85.0 171.0 Metabolism; Lipid Metabolism; alpha-Linolenic acid metabolism beta-Alanine metabolism 26681.0 29880.0 30052.0 28627.0 25310.0 28693.0 32402.0 29929.0 25682.0 30431.0 28851.0 26692.0 25232.0 24422.0 28614.0 25278.0 24193.0 24287.0 26103.0 27461.0 23606.0 23140.0 27938.0 29235.0 26501.0 25008.0 26881.0 28630.0 33011.0 23945.0 23982.0 26588.0 28033.0 27814.0 24867.0 28567.0 30465.0 27100.0 27261.0 25156.0 27555.0 32601.0 23306.0 25393.0 25644.0 30600.0 27675.0 22872.0 19708.0 22613.0 27726.0 Metabolism; Metabolism of Other Amino Acids; beta-Alanine metabolism beta-Lactam resistance 4773.0 5025.0 6287.0 6055.0 5103.0 4284.0 5171.0 6854.0 5926.0 5908.0 5052.0 4824.0 6450.0 5303.0 6732.0 6617.0 4293.0 5466.0 5441.0 5141.0 3876.0 1985.0 4234.0 6673.0 6623.0 4075.0 3904.0 5187.0 5772.0 4161.0 5658.0 5360.0 5766.0 5316.0 5431.0 8285.0 6986.0 6357.0 3204.0 1651.0 4080.0 7247.0 2944.0 3043.0 5189.0 4759.0 8057.0 5028.0 6532.0 4165.0 2430.0 Metabolism; Biosynthesis of Other Secondary Metabolites; beta-Lactam resistance mRNA surveillance pathway 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Genetic Information Processing; Translation; mRNA surveillance pathway mTOR signaling pathway 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Environmental Information Processing; Signal Transduction; mTOR signaling pathway p53 signaling pathway 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 1.0 13.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.0 4.0 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0 Cellular Processes; Cell Growth and Death; p53 signaling pathway