Table 1 The concentration of fospropofol disodium in plasma (μg/mL),,,,,,,,,,
time (min),1,2,3,4,5,6,7,8,9,10
0,0,0,0,0,0,0,0,0,0,0
1,1453.765,367.424,388.03,365.004,934.741,600.547,974.973,628.93,156.959,164.567
2,669.252,358.62,286.789,176.594,464.996,328.806,583.487,475.944,117.695,120.915
3,377.572,211.624,246.611,158.294,337.535,251.857,319.839,233.823,90.906,103.07
4,260.546,124.047,220.794,126.885,175.254,181.022,279.456,209.669,67.506,60.508
5,254.353,121.928,169.374,129.31,144.491,143.007,217.376,162.587,50.266,51.009
7,150.065,93.268,105.526,90.257,109.875,103.606,164.482,144.923,37.873,42.66
10,111.865,66.651,80.038,60.943,85,121.792,210.574,110.758,26.991,26.826
15,61.282,33.347,51.358,27.58,68.431,68.217,141.195,84.578,20.718,11.804
20,40.141,20.091,19.197,19.021,49.039,44.797,76.418,72.053,13.7,8.285
30,19.593,10.35,11.252,9.074,17.711,19.157,56.27,25.597,12.956,8.096
45,5.236,3.166,2.466,2.193,5.076,6.206,18.262,7.968,6.17,4.72
60,2.62,1.531,1.38,0.971,2.419,3.136,14.293,5.539,3.625,3.05
90,0.914,0.676,0.805,0.611,0.808,1.345,4.748,2.173,1.466,0.995
120,0.595,0.635,0.242,ND,0.51,0.459,2.632,1.197,1.138,0.455
180,0.557,0.273,0.136,ND,0.208,0.199,0.243,0.388,0.416,0.166
240,0.408,0.277,ND,ND,ND,ND,0.136,0.158,0.324,ND
ND：Not detected.,,,,,,,,,,
,,,,,,,,,,
Table 2 The concentration of HX0969W in plasma (μg/mL),,,,,,,,,,
time (min),1,2,3,4,5,6,7,8,9,10
0,0,0,0,0,0,0,0,0,0,0
1,302.331,319.074,235.455,381.689,303.093,277.156,291.995,262.407,379.761,460.069
2,140.787,97.113,78.892,101.04,83.947,132.008,114.594,77.316,113.259,165.905
3,40.303,30.655,27.859,31.224,22.517,51.633,25.783,29.801,35.752,48.485
4,13.855,15.787,7.65,10.685,9.252,25.483,13.169,15.607,16.809,22.813
5,7.897,7.834,4.803,4.893,4.557,13.802,7.912,5.219,7.307,10.785
7,4.216,4.447,7.589,4.972,1.369,3.72,2.379,3.101,3.48,4.156
10,3.113,2.837,2.449,2.21,1.942,4.63,2.072,1.457,3.644,4.452
15,1.617,1.338,1.574,0.909,1.017,2.053,1.287,0.985,1.933,1.574
20,1.189,0.925,0.916,1.197,0.971,1.602,0.756,0.683,1.232,1.175
30,1.565,0.681,0.755,0.615,0.527,0.617,0.523,0.449,0.757,0.608
45,0.223,0.391,0.559,0.393,0.364,0.467,0.454,0.319,0.497,0.487
60,0.17,0.301,0.435,0.272,0.249,0.34,0.284,0.336,0.206,0.377
90,0.088,0.188,0.236,0.219,0.156,0.337,0.311,0.114,0.21,0.241
120,0.062,0.149,0.141,ND,0.208,0.184,0.071,0.107,0.199,0.158
180,ND,0.056,0.503,ND,ND,0.155,ND,0.063,0.079,0.108
240,ND,0.051,0.383,ND,ND,0.128,ND,ND,0.063,ND
ND：Not detected.,,,,,,,,,,
,,,,,,,,,,
Table 3 The concentration of propofol in plasma after intravenous administration of propofol (μg/mL),,,,,,,,,,
time (min),1,2,3,4,5,6,7,8,9,10
0,0,0,0,0,0,0,0,0,0,0
0.5,23.302,24.33,23.996,15.201,21.754,30.698,18.897,26.256,20.264,29.329
1,14.892,11.858,16.764,13.334,15.529,21.352,12.905,17.389,13.347,24.012
2,10.6,9.766,12.262,11.254,15.504,17.659,11.418,13.769,10.619,18.347
3,7.59,9.714,9.336,8.639,13.61,12.81,9.143,11.296,11.135,17
4,7.612,7.403,7.287,6.151,10.634,12.232,8.595,8.08,8.819,13.026
5,6.091,6.106,6.346,5.308,7.925,9.902,6.321,6.659,7.388,10.677
7,4.095,4.088,5.125,3.676,5.796,7.663,4.409,4.711,6.435,8.869
10,3.506,3.459,4.22,3.233,4.216,5.342,3.887,4.494,4.571,6.008
15,3.099,2.009,3.887,2.317,2.496,3.043,3.078,2.773,3.711,4.379
20,2.279,1.62,3.353,1.966,1.825,1.774,2.19,1.871,2.768,2.998
30,1.605,0.876,1.795,1.552,1.682,1.239,1.719,1.206,2.321,2.063
45,0.896,0.498,1.318,0.913,1.121,0.778,1.084,1.036,1.395,1.523
60,0.506,0.339,0.657,0.487,1.062,0.518,0.682,0.762,0.943,0.892
90,0.35,0.179,0.461,0.287,0.517,0.256,0.405,0.322,0.863,0.472
120,0.185,0.169,0.314,0.24,0.268,0.222,0.278,0.171,0.429,0.28
180,0.144,0.09,0.14,0.118,0.142,0.131,0.145,0.108,0.285,0.126
,,,,,,,,,,
Table 4 The concentration of propofol in plasma after intravenous administration of HX0969W (μg/mL),,,,,,,,,,
time (min),1,2,3,4,5,6,7,8,9,10
0,0,0,0,0,0,0,0,0,0,0
1,7.108,8.995,7.998,4.505,4.621,3.279,6.114,6.507,6.74,7.81
2,19.237,11.981,14.526,10.919,10.745,20.791,16.24,13.5,13.28,14.13
3,24.165,19.052,21.402,18.074,18.735,18.883,28.202,14.805,22.23,20.56
4,17.896,19.398,23.818,18.828,21.962,28.348,28.923,15.701,27.93,31.45
5,21.026,16.482,25.882,17.191,19.313,25.665,27.418,15.247,26.79,29.72
7,16.206,13.872,19.52,13.832,15.542,22.987,23.819,12.615,21.36,25.34
10,14.602,12.317,13.959,13.098,12.197,18.97,18.698,8.672,21.14,24.79
15,8.279,7.458,10.227,8.471,9.079,13.352,12.922,7.707,14.17,19.41
20,6.19,7.407,6.144,6.527,8.996,9.033,10.057,6.296,10.07,13.29
30,4.758,5.523,6.093,5.303,7.312,6.495,9.083,4.253,8.22,10.5
45,2.984,4.123,4.598,3.55,4.777,4.562,7.369,2.857,5.49,7.28
60,2.46,3.452,3.044,2.952,3.605,3.553,4.662,1.531,3.84,4.82
90,1.364,1.766,1.752,1.922,1.953,2.382,2.112,0.923,2.34,2.55
120,0.908,1.511,1.098,1.099,1.262,1.642,1.281,0.571,1.19,2.13
180,0.736,0.877,0.954,0.643,0.624,0.988,0.733,0.362,1.05,1.22
240,0.691,0.546,0.53,0.596,0.39,0.623,0.618,0.68,0.62,0.73
,,,,,,,,,,
Table 5 The concentration of propofol in plasma after intravenous administration of fospropofol disodium (μg/mL),,,,,,,,,,
time (min),1,2,3,4,5,6,7,8,9,10
0,0,0,0,0,0,0,0,0,0,0
1,5.259,8.271,4.616,9.344,6.256,8.121,3.451,3.722,6.61,5.635
2,15.15,10.77,8.611,11.777,14.891,13.39,9.327,11.301,14.152,12.141
3,2.499,11.09,17.523,17.188,19.967,21.105,12.362,11.429,16.47,21.554
4,21.337,12.282,28.116,17.199,17.979,31.415,16.695,17.684,16.6,20.352
5,21.264,15.321,24.172,21.498,15.944,23.591,18.489,17.662,13.747,21.679
7,18.829,12.508,20.218,17.449,17.836,17.004,14.084,21.513,11.605,18.351
10,15.253,7.859,16.451,9.298,15.159,18.617,16.606,13.911,9.571,15.204
15,11.847,5.303,14.016,6.225,10.638,14.495,15.442,17.168,7.228,9.614
20,8.409,3.338,6.992,0.116,8.843,14.479,11.972,15.504,5.553,7.039
30,7.192,2.923,7.786,5.229,6.281,10.567,10.694,9.926,3.996,5.528
45,4.726,1.414,3.616,2.387,3.918,5.009,7.537,5.551,2.907,3.41
60,3.297,1.235,3.043,2.062,2.794,4.483,7.388,4.953,2.366,2.913
90,2.089,0.962,2.533,0.82,2.128,2.545,3.798,2.603,1.425,1.515
120,1.281,0.963,1.246,0.551,1.467,1.895,2.552,1.901,0.895,0.902
180,0.759,0.416,0.51,0.392,0.403,1.184,0.793,0.872,0.533,0.496
240,0.547,0.301,0.392,0.31,0.477,0.677,0.673,0.511,0.335,0.338