DB ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa05340 Primary immunodeficiency 3/12 37/7840 2.06766515301947e-05 0.000868419364268179 0.000609417097732056 CD3E/BTK/CD4 3 KEGG hsa04062 Chemokine signaling pathway 3/12 190/7840 0.00262272377248042 0.027472132187088 0.0192786892540969 WAS/DOCK2/CCR5 3 KEGG hsa05169 Epstein-Barr virus infection 3/12 201/7840 0.00307828098004887 0.027472132187088 0.0192786892540969 CD3E/BTK/ITGAL 3 KEGG hsa05170 Human immunodeficiency virus 1 infection 3/12 212/7840 0.00358026138007474 0.027472132187088 0.0192786892540969 CD3E/CD4/CCR5 3 KEGG hsa04810 Regulation of actin cytoskeleton 3/12 214/7840 0.00367664123566405 0.027472132187088 0.0192786892540969 WAS/ITGAL/NCKAP1L 3 KEGG hsa05166 Human T-cell leukemia virus 1 infection 3/12 219/7840 0.00392459031244115 0.027472132187088 0.0192786892540969 CD3E/ITGAL/CD4 3 KEGG hsa04666 Fc gamma R-mediated phagocytosis 2/12 91/7840 0.00815415172973341 0.0418769018027883 0.0293872995107287 WAS/DOCK2 2 KEGG hsa04658 Th1 and Th2 cell differentiation 2/12 92/7840 0.00832827352602734 0.0418769018027883 0.0293872995107287 CD3E/CD4 2 KEGG hsa04640 Hematopoietic cell lineage 2/12 97/7840 0.00922408256788583 0.0418769018027883 0.0293872995107287 CD3E/CD4 2 KEGG hsa04660 T cell receptor signaling pathway 2/12 101/7840 0.0099706909054258 0.0418769018027883 0.0293872995107287 CD3E/CD4 2 KEGG hsa04659 Th17 cell differentiation 2/12 107/7840 0.0111398461292895 0.0425339579481963 0.0298483915425939 CD3E/CD4 2 BP GO:0042110 T cell activation 9/17 467/17381 1.3577032967003e-10 6.96501791207253e-08 2.92978079814275e-08 WAS/DOCK2/SIRPG/CD3E/RASAL3/ITGAL/CD4/NCKAP1L/SASH3 9 BP GO:0007159 leukocyte cell-cell adhesion 8/17 374/17381 8.75574891642607e-10 2.24584959706329e-07 9.44699225193339e-08 FERMT3/SIRPG/CD3E/RASAL3/ITGAL/CD4/NCKAP1L/SASH3 8 BP GO:0046651 lymphocyte proliferation 7/17 268/17381 3.26654090124751e-09 4.41125281838625e-07 1.85555930597965e-07 DOCK2/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0032943 mononuclear cell proliferation 7/17 270/17381 3.43957334766959e-09 4.41125281838625e-07 1.85555930597965e-07 DOCK2/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0070661 leukocyte proliferation 7/17 286/17381 5.12741592705349e-09 5.26072874115688e-07 2.21288476851782e-07 DOCK2/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0051251 positive regulation of lymphocyte activation 7/17 315/17381 1.00014662487711e-08 8.5512536426993e-07 3.59701856315452e-07 SIRPG/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0042098 T cell proliferation 6/17 181/17381 1.32075635384263e-08 9.67925727887531e-07 4.0715045494397e-07 DOCK2/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0002696 positive regulation of leukocyte activation 7/17 347/17381 1.94895664005386e-08 1.24976844543454e-06 5.25705409488212e-07 SIRPG/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0050867 positive regulation of cell activation 7/17 359/17381 2.46253046852379e-08 1.37319514493613e-06 5.77623893940507e-07 SIRPG/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0050670 regulation of lymphocyte proliferation 6/17 206/17381 2.86069048610854e-08 1.37319514493613e-06 5.77623893940507e-07 CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0032944 regulation of mononuclear cell proliferation 6/17 207/17381 2.94447302033088e-08 1.37319514493613e-06 5.77623893940507e-07 CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0042102 positive regulation of T cell proliferation 5/17 101/17381 3.51028398135689e-08 1.42900180512903e-06 6.01098532987484e-07 CD3E/RASAL3/CD4/NCKAP1L/SASH3 5 BP GO:0050870 positive regulation of T cell activation 6/17 215/17381 3.69068559254772e-08 1.42900180512903e-06 6.01098532987484e-07 SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0070663 regulation of leukocyte proliferation 6/17 217/17381 3.89980999450416e-08 1.42900180512903e-06 6.01098532987484e-07 CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 6/17 226/17381 4.96605905774622e-08 1.69839219774921e-06 7.14415513570508e-07 SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0022407 regulation of cell-cell adhesion 7/17 425/17381 7.82980769086556e-08 2.41719307755107e-06 1.01677353215958e-06 FERMT3/SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0046631 alpha-beta T cell activation 5/17 119/17381 8.01019148506204e-08 2.41719307755107e-06 1.01677353215958e-06 DOCK2/CD3E/RASAL3/NCKAP1L/SASH3 5 BP GO:0022409 positive regulation of cell-cell adhesion 6/17 259/17381 1.11439230381161e-07 3.17601806586308e-06 1.33596738176245e-06 SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0051249 regulation of lymphocyte activation 7/17 455/17381 1.24695288195875e-07 3.36677278128863e-06 1.41620687424678e-06 SIRPG/CD3E/BTK/RASAL3/CD4/NCKAP1L/SASH3 7 BP GO:0050671 positive regulation of lymphocyte proliferation 5/17 136/17381 1.5631767364085e-07 3.8403908455677e-06 1.61543064192342e-06 CD3E/RASAL3/CD4/NCKAP1L/SASH3 5 BP GO:0032946 positive regulation of mononuclear cell proliferation 5/17 137/17381 1.62145027070865e-07 3.8403908455677e-06 1.61543064192342e-06 CD3E/RASAL3/CD4/NCKAP1L/SASH3 5 BP GO:0046635 positive regulation of alpha-beta T cell activation 4/17 52/17381 1.64695123981461e-07 3.8403908455677e-06 1.61543064192342e-06 CD3E/RASAL3/NCKAP1L/SASH3 4 BP GO:0070665 positive regulation of leukocyte proliferation 5/17 144/17381 2.07936219965204e-07 4.63788177574564e-06 1.9508890202685e-06 CD3E/RASAL3/CD4/NCKAP1L/SASH3 5 BP GO:0042129 regulation of T cell proliferation 5/17 155/17381 3.00052602078715e-07 6.41362436943253e-06 2.69784137833932e-06 CD3E/RASAL3/CD4/NCKAP1L/SASH3 5 BP GO:0050863 regulation of T cell activation 6/17 322/17381 4.02108301827021e-07 8.25126235349048e-06 3.47082955261219e-06 SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0030098 lymphocyte differentiation 6/17 328/17381 4.48118749233527e-07 8.84172762910767e-06 3.71920419404344e-06 DOCK2/CD3E/BTK/CD4/NCKAP1L/SASH3 6 BP GO:1903037 regulation of leukocyte cell-cell adhesion 6/17 343/17381 5.82386525924888e-07 1.10653439925729e-05 4.65455118185583e-06 SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0046634 regulation of alpha-beta T cell activation 4/17 79/17381 8.99367865816919e-07 1.64777041130028e-05 6.93121851475445e-06 CD3E/RASAL3/NCKAP1L/SASH3 4 BP GO:0045785 positive regulation of cell adhesion 6/17 394/17381 1.30832023237809e-06 2.31437337658606e-05 9.73523221914728e-06 SIRPG/CD3E/RASAL3/CD4/NCKAP1L/SASH3 6 BP GO:0030217 T cell differentiation 5/17 225/17381 1.89542708058515e-06 3.24118030780061e-05 1.36337737375423e-05 DOCK2/CD3E/CD4/NCKAP1L/SASH3 5 BP GO:0046633 alpha-beta T cell proliferation 3/17 27/17381 2.24045724772386e-06 3.70759538091077e-05 1.55957125902679e-05 DOCK2/CD3E/RASAL3 3 BP GO:0032743 positive regulation of interleukin-2 production 3/17 30/17381 3.10419687959312e-06 4.97641562259773e-05 2.09329065893615e-05 CD3E/CD4/SASH3 3 BP GO:0050851 antigen receptor-mediated signaling pathway 5/17 257/17381 3.63774217010414e-06 5.6550355553437e-05 2.37874687359282e-05 WAS/CD3E/BTK/CD4/NCKAP1L 5 BP GO:0002521 leukocyte differentiation 6/17 479/17381 4.05819927553438e-06 6.12310655396805e-05 2.57563731109767e-05 DOCK2/CD3E/BTK/CD4/NCKAP1L/SASH3 6 BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4/17 124/17381 5.46584758490281e-06 8.01137088872898e-05 3.36992106738369e-05 WAS/BTK/CD4/SASH3 4 BP GO:1902107 positive regulation of leukocyte differentiation 4/17 133/17381 7.21903506586511e-06 0.000102871249688578 4.32719938158581e-05 BTK/CD4/NCKAP1L/SASH3 4 BP GO:0002819 regulation of adaptive immune response 4/17 135/17381 7.65916705535864e-06 0.000106193316199973 4.46693953441969e-05 WAS/BTK/CD4/SASH3 4 BP GO:0045058 T cell selection 3/17 47/17381 1.22709181841643e-05 0.000165657395486218 6.96824993837584e-05 DOCK2/CD3E/CD4 3 BP GO:0032663 regulation of interleukin-2 production 3/17 52/17381 1.6673993308359e-05 0.000219327142748415 9.22582625698678e-05 CD3E/CD4/SASH3 3 BP GO:0019722 calcium-mediated signaling 4/17 167/17381 1.77468853988978e-05 0.000227603805240865 9.57397764940541e-05 CD3E/BTK/CD4/CCR5 4 BP GO:1903708 positive regulation of hemopoiesis 4/17 169/17381 1.85980930570701e-05 0.000232702969226268 9.78847003003691e-05 BTK/CD4/NCKAP1L/SASH3 4 BP GO:0032623 interleukin-2 production 3/17 59/17381 2.4423789064221e-05 0.000298319137855842 0.000125485633036724 CD3E/CD4/SASH3 3 BP GO:0030888 regulation of B cell proliferation 3/17 60/17381 2.56937130711909e-05 0.000306531972221417 0.000128940298154079 BTK/NCKAP1L/SASH3 3 BP GO:0002429 immune response-activating cell surface receptor signaling pathway 5/17 426/17381 4.19050325828713e-05 0.000488574584432113 0.000205515111949488 WAS/CD3E/BTK/CD4/NCKAP1L 5 BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3/17 79/17381 5.86974235935197e-05 0.000632447894522774 0.000266034304662293 BTK/CD4/SASH3 3 BP GO:0045060 negative thymic T cell selection 2/17 12/17381 5.90865934702771e-05 0.000632447894522774 0.000266034304662293 DOCK2/CD3E 2 BP GO:0045086 positive regulation of interleukin-2 biosynthetic process 2/17 12/17381 5.90865934702771e-05 0.000632447894522774 0.000266034304662293 CD3E/CD4 2 BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 5/17 458/17381 5.91764111834174e-05 0.000632447894522774 0.000266034304662293 WAS/CD3E/BTK/CD4/NCKAP1L 5 BP GO:0002821 positive regulation of adaptive immune response 3/17 83/17381 6.80351283979437e-05 0.000701999677538638 0.000295290723084889 BTK/CD4/SASH3 3 BP GO:0043383 negative T cell selection 2/17 13/17381 6.97894416266482e-05 0.000701999677538638 0.000295290723084889 DOCK2/CD3E 2 BP GO:0045579 positive regulation of B cell differentiation 2/17 13/17381 6.97894416266482e-05 0.000701999677538638 0.000295290723084889 BTK/NCKAP1L 2 BP GO:0045621 positive regulation of lymphocyte differentiation 3/17 85/17381 7.30478358860489e-05 0.000720644996337367 0.00030313373191579 BTK/NCKAP1L/SASH3 3 BP GO:1902105 regulation of leukocyte differentiation 4/17 254/17381 9.12585247850771e-05 0.000883313645561218 0.000371559038350364 BTK/CD4/NCKAP1L/SASH3 4 BP GO:0042100 B cell proliferation 3/17 93/17381 9.55085796089437e-05 0.000907331506284965 0.000381661965298898 BTK/NCKAP1L/SASH3 3 BP GO:0045076 regulation of interleukin-2 biosynthetic process 2/17 18/17381 0.000136501423937942 0.00127318600873026 0.000535555825976616 CD3E/CD4 2 BP GO:0046641 positive regulation of alpha-beta T cell proliferation 2/17 19/17381 0.000152472671327577 0.00139675857841156 0.000587535669589349 CD3E/RASAL3 2 BP GO:0019932 second-messenger-mediated signaling 4/17 300/17381 0.000173371332327808 0.00156034199095027 0.000656345764121895 CD3E/BTK/CD4/CCR5 4 BP GO:0042094 interleukin-2 biosynthetic process 2/17 21/17381 0.000187031824778358 0.00161337398988769 0.000678653263418438 CD3E/CD4 2 BP GO:0045061 thymic T cell selection 2/17 21/17381 0.000187031824778358 0.00161337398988769 0.000678653263418438 DOCK2/CD3E 2 BP GO:0050871 positive regulation of B cell activation 3/17 117/17381 0.000188698712267566 0.00161337398988769 0.000678653263418438 BTK/NCKAP1L/SASH3 3 BP GO:0032753 positive regulation of interleukin-4 production 2/17 22/17381 0.000205616691088786 0.00170216543744628 0.000716002697602315 CD3E/SASH3 2 BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4/17 314/17381 0.000206507857364261 0.00170216543744628 0.000716002697602315 WAS/BTK/CD4/SASH3 4 BP GO:0006909 phagocytosis 4/17 315/17381 0.000209037860739017 0.00170216543744628 0.000716002697602315 WAS/DOCK2/ITGAL/NCKAP1L 4 BP GO:0002706 regulation of lymphocyte mediated immunity 3/17 124/17381 0.000224014110040549 0.00179561310079378 0.000755310732866983 WAS/BTK/SASH3 3 BP GO:0046640 regulation of alpha-beta T cell proliferation 2/17 24/17381 0.000245389417327873 0.00193668878598768 0.000814653126351644 CD3E/RASAL3 2 BP GO:0045577 regulation of B cell differentiation 2/17 26/17381 0.000288622709126563 0.00224338560275646 0.000943662765086848 BTK/NCKAP1L 2 BP GO:0032673 regulation of interleukin-4 production 2/17 27/17381 0.00031153328927687 0.00235024378527992 0.000988611831296569 CD3E/SASH3 2 BP GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 2/17 27/17381 0.00031153328927687 0.00235024378527992 0.000988611831296569 NCKAP1L/SASH3 2 BP GO:0050690 regulation of defense response to virus by virus 2/17 29/17381 0.00035993477846345 0.00267603683118478 0.00112565415080103 DOCK2/CD4 2 BP GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 2/17 31/17381 0.000411766674707264 0.00301766148749752 0.00126935591451111 NCKAP1L/SASH3 2 BP GO:0050864 regulation of B cell activation 3/17 155/17381 0.000431509140205105 0.00311780547781998 0.00131148070781388 BTK/NCKAP1L/SASH3 3 BP GO:0045619 regulation of lymphocyte differentiation 3/17 156/17381 0.000439704069076085 0.0031328914921671 0.00131782652281575 BTK/NCKAP1L/SASH3 3 BP GO:0032633 interleukin-4 production 2/17 33/17381 0.000467016965849934 0.00328191374631529 0.00138051157893636 CD3E/SASH3 2 BP GO:0002703 regulation of leukocyte mediated immunity 3/17 165/17381 0.000518005863253373 0.00359104064660784 0.00151054341347001 WAS/BTK/SASH3 3 BP GO:0043547 positive regulation of GTPase activity 4/17 407/17381 0.000553520872020356 0.00378608276461924 0.00159258636861997 DOCK2/ARHGAP9/RASAL3/NCKAP1L 4 BP GO:0050852 T cell receptor signaling pathway 3/17 174/17381 0.000604754074643916 0.00408209000384643 0.00171709951941832 WAS/CD3E/CD4 3 BP GO:0050850 positive regulation of calcium-mediated signaling 2/17 38/17381 0.000620019604868193 0.00413077996490108 0.00173758057413506 CD3E/CD4 2 BP GO:0033628 regulation of cell adhesion mediated by integrin 2/17 39/17381 0.000653158524640743 0.00429577337359873 0.00180698377262284 FERMT3/NCKAP1L 2 BP GO:0046638 positive regulation of alpha-beta T cell differentiation 2/17 40/17381 0.000687140103365134 0.00446206168387739 0.00187693166142375 NCKAP1L/SASH3 2 BP GO:0030890 positive regulation of B cell proliferation 2/17 41/17381 0.000721962856790989 0.00457243142634293 0.00192335783810465 NCKAP1L/SASH3 2 BP GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 2/17 41/17381 0.000721962856790989 0.00457243142634293 0.00192335783810465 NCKAP1L/SASH3 2 BP GO:1903706 regulation of hemopoiesis 4/17 448/17381 0.0007937771513739 0.00496594730066842 0.00208888724045763 BTK/CD4/NCKAP1L/SASH3 4 BP GO:0050766 positive regulation of phagocytosis 2/17 46/17381 0.000908642422152262 0.00561606701884471 0.00236235506076365 DOCK2/NCKAP1L 2 BP GO:0044764 multi-organism cellular process 2/17 47/17381 0.000948481155661957 0.00577583250737745 0.00242955917515621 CD4/CCR5 2 BP GO:0050900 leukocyte migration 4/17 471/17381 0.000957009284848116 0.00577583250737745 0.00242955917515621 SIRPG/ITGAL/NCKAP1L/CCR5 4 BP GO:0043087 regulation of GTPase activity 4/17 475/17381 0.000987650173911909 0.00589144813042802 0.00247819199084384 DOCK2/ARHGAP9/RASAL3/NCKAP1L 4 BP GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 2/17 49/17381 0.00103064965927792 0.0060772790253974 0.00255636031641832 NCKAP1L/SASH3 2 BP GO:0043312 neutrophil degranulation 4/17 485/17381 0.0010672897974708 0.00619920818850909 0.00260764887379576 DOCK2/ARHGAP9/ITGAL/NCKAP1L 4 BP GO:0002283 neutrophil activation involved in immune response 4/17 486/17381 0.00107549615746064 0.00619920818850909 0.00260764887379576 DOCK2/ARHGAP9/ITGAL/NCKAP1L 4 BP GO:0042119 neutrophil activation 4/17 496/17381 0.00116003623548211 0.00661220654224805 0.00278137343010331 DOCK2/ARHGAP9/ITGAL/NCKAP1L 4 BP GO:0002446 neutrophil mediated immunity 4/17 499/17381 0.00118628870748804 0.00668753963671828 0.00281306171237765 DOCK2/ARHGAP9/ITGAL/NCKAP1L 4 BP GO:0002709 regulation of T cell mediated immunity 2/17 55/17381 0.00129697786053834 0.00715429723071151 0.00300939967640476 WAS/SASH3 2 BP GO:0033627 cell adhesion mediated by integrin 2/17 55/17381 0.00129697786053834 0.00715429723071151 0.00300939967640476 FERMT3/NCKAP1L 2 BP GO:0046637 regulation of alpha-beta T cell differentiation 2/17 56/17381 0.0013442413497193 0.00733612566389362 0.00308588439745192 NCKAP1L/SASH3 2 BP GO:0042108 positive regulation of cytokine biosynthetic process 2/17 60/17381 0.00154145749159731 0.00832387045462548 0.00350137158756176 CD3E/CD4 2 BP GO:0038093 Fc receptor signaling pathway 3/17 246/17381 0.00164448154244108 0.00878769824241953 0.00369647715132041 WAS/BTK/NCKAP1L 3 BP GO:0032729 positive regulation of interferon-gamma production 2/17 63/17381 0.00169789928669268 0.00897961169147778 0.00377720405612587 CD3E/SASH3 2 BP GO:0043367 CD4-positive, alpha-beta T cell differentiation 2/17 66/17381 0.00186160888359642 0.00974495262535679 0.00409913878772575 NCKAP1L/SASH3 2 BP GO:0002718 regulation of cytokine production involved in immune response 2/17 67/17381 0.00191778709411164 0.00993762403312393 0.00418018452198709 BTK/SASH3 2 BP GO:0033077 T cell differentiation in thymus 2/17 68/17381 0.00197476708216482 0.010030252605451 0.00421914801296287 DOCK2/CD3E 2 BP GO:0050764 regulation of phagocytosis 2/17 68/17381 0.00197476708216482 0.010030252605451 0.00421914801296287 DOCK2/NCKAP1L 2 BP GO:0042113 B cell activation 3/17 271/17381 0.00216797295252715 0.0109036286730042 0.00458652688615136 BTK/NCKAP1L/SASH3 3 BP GO:0045582 positive regulation of T cell differentiation 2/17 74/17381 0.00233340414090936 0.0116217118862767 0.00488858302387755 NCKAP1L/SASH3 2 BP GO:0035710 CD4-positive, alpha-beta T cell activation 2/17 75/17381 0.00239595650963696 0.0118185162446515 0.00497136725177709 NCKAP1L/SASH3 2 BP GO:0031295 T cell costimulation 2/17 76/17381 0.00245929923062356 0.0120154333839037 0.0050541989200785 CD3E/CD4 2 BP GO:0002708 positive regulation of lymphocyte mediated immunity 2/17 78/17381 0.0025883500499746 0.0125266375060091 0.0052692329716464 BTK/SASH3 2 BP GO:0031294 lymphocyte costimulation 2/17 79/17381 0.00265405531299748 0.0127245829492309 0.00535249718804214 CD3E/CD4 2 BP GO:0050848 regulation of calcium-mediated signaling 2/17 80/17381 0.00272054525759278 0.0129225899735657 0.00543578730805574 CD3E/CD4 2 BP GO:0002456 T cell mediated immunity 2/17 83/17381 0.00292470905628982 0.013764915099786 0.00579010484345159 WAS/SASH3 2 BP GO:0045639 positive regulation of myeloid cell differentiation 2/17 86/17381 0.00313588421371646 0.0146246236512413 0.0061517345819318 CD4/NCKAP1L 2 BP GO:0002367 cytokine production involved in immune response 2/17 87/17381 0.00320782745348582 0.0148253647174615 0.00623617475547268 BTK/SASH3 2 BP GO:0002449 lymphocyte mediated immunity 3/17 314/17381 0.00329076268571835 0.0150728683729778 0.0063402852497393 WAS/BTK/SASH3 3 BP GO:0030838 positive regulation of actin filament polymerization 2/17 91/17381 0.00350332066186288 0.0158283365728976 0.0066580670923238 WAS/NCKAP1L 2 BP GO:0032649 regulation of interferon-gamma production 2/17 92/17381 0.00357911704182479 0.0158283365728976 0.0066580670923238 CD3E/SASH3 2 BP GO:0046632 alpha-beta T cell differentiation 2/17 92/17381 0.00357911704182479 0.0158283365728976 0.0066580670923238 NCKAP1L/SASH3 2 BP GO:0050853 B cell receptor signaling pathway 2/17 92/17381 0.00357911704182479 0.0158283365728976 0.0066580670923238 BTK/NCKAP1L 2 BP GO:0007229 integrin-mediated signaling pathway 2/17 96/17381 0.0038899530953073 0.0170559481871166 0.0071744524025011 FERMT3/ITGAL 2 BP GO:0002705 positive regulation of leukocyte mediated immunity 2/17 97/17381 0.003969567800551 0.0171125065687619 0.00719824324735033 BTK/SASH3 2 BP GO:0042035 regulation of cytokine biosynthetic process 2/17 97/17381 0.003969567800551 0.0171125065687619 0.00719824324735033 CD3E/CD4 2 BP GO:0032609 interferon-gamma production 2/17 102/17381 0.00437900629774411 0.0187202519228561 0.00787452886875037 CD3E/SASH3 2 BP GO:0051668 localization within membrane 2/17 105/17381 0.00463371176252693 0.0196454060675728 0.00826368778876051 DOCK2/ITGAL 2 BP GO:0042089 cytokine biosynthetic process 2/17 108/17381 0.004895153694283 0.0205837200423539 0.00865838228928399 CD3E/CD4 2 BP GO:0042107 cytokine metabolic process 2/17 110/17381 0.00507317256432598 0.0211588416707254 0.00890030274443154 CD3E/CD4 2 BP GO:0018108 peptidyl-tyrosine phosphorylation 3/17 375/17381 0.00541061682991567 0.0223842454334414 0.00941575933898738 CD3E/BTK/CD4 3 BP GO:0032273 positive regulation of protein polymerization 2/17 115/17381 0.00553117516217837 0.0225223830902294 0.00947386587359604 WAS/NCKAP1L 2 BP GO:0018212 peptidyl-tyrosine modification 3/17 378/17381 0.00553181339058266 0.0225223830902294 0.00947386587359604 CD3E/BTK/CD4 3 BP GO:0002700 regulation of production of molecular mediator of immune response 2/17 117/17381 0.00571952987507627 0.0231032978418435 0.00971822316113249 BTK/SASH3 2 BP GO:0030183 B cell differentiation 2/17 118/17381 0.00581480617929242 0.0231239966664884 0.00972692996128066 BTK/NCKAP1L 2 BP GO:0046718 viral entry into host cell 2/17 118/17381 0.00581480617929242 0.0231239966664884 0.00972692996128066 CD4/CCR5 2 BP GO:0045807 positive regulation of endocytosis 2/17 119/17381 0.00591081331674721 0.0233249787037794 0.00981147149743463 DOCK2/NCKAP1L 2 BP GO:0002697 regulation of immune effector process 3/17 402/17381 0.00656097531640714 0.0256929796741745 0.0108075527510122 WAS/BTK/SASH3 3 BP GO:0001819 positive regulation of cytokine production 3/17 409/17381 0.00688138468197656 0.0266558851323649 0.0112125914684206 CD3E/CD4/SASH3 3 BP GO:0045580 regulation of T cell differentiation 2/17 129/17381 0.00691078503431682 0.0266558851323649 0.0112125914684206 NCKAP1L/SASH3 2 BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 2/17 132/17381 0.00722480137894898 0.0274499600093529 0.0115466129104696 WAS/NCKAP1L 2 BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 2/17 132/17381 0.00722480137894898 0.0274499600093529 0.0115466129104696 WAS/NCKAP1L 2 BP GO:0030260 entry into host cell 2/17 134/17381 0.0074377084625732 0.0274499600093529 0.0115466129104696 CD4/CCR5 2 BP GO:0044409 entry into host 2/17 134/17381 0.0074377084625732 0.0274499600093529 0.0115466129104696 CD4/CCR5 2 BP GO:0051806 entry into cell of other organism involved in symbiotic interaction 2/17 134/17381 0.0074377084625732 0.0274499600093529 0.0115466129104696 CD4/CCR5 2 BP GO:0051828 entry into other organism involved in symbiotic interaction 2/17 134/17381 0.0074377084625732 0.0274499600093529 0.0115466129104696 CD4/CCR5 2 BP GO:0038094 Fc-gamma receptor signaling pathway 2/17 136/17381 0.00765345347913407 0.0280444402485413 0.0117966764152067 WAS/NCKAP1L 2 BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 2/17 137/17381 0.00776238691241334 0.0282418757877166 0.0118797261444176 WAS/NCKAP1L 2 BP GO:0002377 immunoglobulin production 2/17 139/17381 0.00798236904363072 0.0288377135167786 0.0121303606667479 BTK/SASH3 2 BP GO:0030833 regulation of actin filament polymerization 2/17 142/17381 0.0083176106952424 0.0298387013053101 0.0125514184212344 WAS/NCKAP1L 2 BP GO:0060402 calcium ion transport into cytosol 2/17 145/17381 0.00865914304989965 0.0308481971152675 0.0129760550089871 CD4/CCR5 2 BP GO:0001768 establishment of T cell polarity 1/17 10/17381 0.00974036941999501 0.0333120634163829 0.01401246127087 DOCK2 1 BP GO:0001821 histamine secretion 1/17 10/17381 0.00974036941999501 0.0333120634163829 0.01401246127087 BTK 1 BP GO:0002524 hypersensitivity 1/17 10/17381 0.00974036941999501 0.0333120634163829 0.01401246127087 BTK 1 BP GO:0045059 positive thymic T cell selection 1/17 10/17381 0.00974036941999501 0.0333120634163829 0.01401246127087 DOCK2 1 BP GO:0051132 NK T cell activation 1/17 10/17381 0.00974036941999501 0.0333120634163829 0.01401246127087 RASAL3 1 BP GO:0051665 membrane raft localization 1/17 10/17381 0.00974036941999501 0.0333120634163829 0.01401246127087 DOCK2 1 BP GO:0030041 actin filament polymerization 2/17 157/17381 0.0100874764335485 0.0339201400834615 0.0142682440076118 WAS/NCKAP1L 2 BP GO:0060401 cytosolic calcium ion transport 2/17 157/17381 0.0100874764335485 0.0339201400834615 0.0142682440076118 CD4/CCR5 2 BP GO:0032844 regulation of homeostatic process 3/17 473/17381 0.0102493953926836 0.0339201400834615 0.0142682440076118 CD4/NCKAP1L/CCR5 3 BP GO:0008064 regulation of actin polymerization or depolymerization 2/17 161/17381 0.0105854424659301 0.0339201400834615 0.0142682440076118 WAS/NCKAP1L 2 BP GO:0001767 establishment of lymphocyte polarity 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 DOCK2 1 BP GO:0002664 regulation of T cell tolerance induction 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 CD3E 1 BP GO:0002863 positive regulation of inflammatory response to antigenic stimulus 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 BTK 1 BP GO:0032488 Cdc42 protein signal transduction 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 WAS 1 BP GO:0043374 CD8-positive, alpha-beta T cell differentiation 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 NCKAP1L 1 BP GO:0051608 histamine transport 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 BTK 1 BP GO:0060099 regulation of phagocytosis, engulfment 1/17 11/17381 0.0107094796450751 0.0339201400834615 0.0142682440076118 NCKAP1L 1 BP GO:0030832 regulation of actin filament length 2/17 162/17381 0.010711623184251 0.0339201400834615 0.0142682440076118 WAS/NCKAP1L 2 BP GO:0032700 negative regulation of interleukin-17 production 1/17 12/17381 0.0116776971952206 0.0360883051876396 0.0151802658530135 NCKAP1L 1 BP GO:0033631 cell-cell adhesion mediated by integrin 1/17 12/17381 0.0116776971952206 0.0360883051876396 0.0151802658530135 FERMT3 1 BP GO:0051127 positive regulation of actin nucleation 1/17 12/17381 0.0116776971952206 0.0360883051876396 0.0151802658530135 WAS 1 BP GO:1905153 regulation of membrane invagination 1/17 12/17381 0.0116776971952206 0.0360883051876396 0.0151802658530135 NCKAP1L 1 BP GO:0007584 response to nutrient 2/17 173/17381 0.012143757863037 0.037269699899884 0.0156772103816071 CD3E/CD4 2 BP GO:0002699 positive regulation of immune effector process 2/17 174/17381 0.0122779323256928 0.037269699899884 0.0156772103816071 BTK/SASH3 2 BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2/17 174/17381 0.0122779323256928 0.037269699899884 0.0156772103816071 CD3E/CD4 2 BP GO:0001771 immunological synapse formation 1/17 13/17381 0.0126450228413532 0.0372810156184722 0.0156819702509219 DOCK2 1 BP GO:0002517 T cell tolerance induction 1/17 13/17381 0.0126450228413532 0.0372810156184722 0.0156819702509219 CD3E 1 BP GO:0035723 interleukin-15-mediated signaling pathway 1/17 13/17381 0.0126450228413532 0.0372810156184722 0.0156819702509219 CD4 1 BP GO:0046629 gamma-delta T cell activation 1/17 13/17381 0.0126450228413532 0.0372810156184722 0.0156819702509219 NCKAP1L 1 BP GO:0071350 cellular response to interleukin-15 1/17 13/17381 0.0126450228413532 0.0372810156184722 0.0156819702509219 CD4 1 BP GO:0007163 establishment or maintenance of cell polarity 2/17 182/17381 0.0133749083452233 0.0387926534582518 0.0163178289913648 DOCK2/NCKAP1L 2 BP GO:1902905 positive regulation of supramolecular fiber organization 2/17 182/17381 0.0133749083452233 0.0387926534582518 0.0163178289913648 WAS/NCKAP1L 2 BP GO:0032271 regulation of protein polymerization 2/17 183/17381 0.0135149591312183 0.0387926534582518 0.0163178289913648 WAS/NCKAP1L 2 BP GO:0002726 positive regulation of T cell cytokine production 1/17 14/17381 0.0136114573537726 0.0387926534582518 0.0163178289913648 SASH3 1 BP GO:0002864 regulation of acute inflammatory response to antigenic stimulus 1/17 14/17381 0.0136114573537726 0.0387926534582518 0.0163178289913648 BTK 1 BP GO:0070672 response to interleukin-15 1/17 14/17381 0.0136114573537726 0.0387926534582518 0.0163178289913648 CD4 1 BP GO:0008154 actin polymerization or depolymerization 2/17 185/17381 0.0137969995228214 0.0391042030674442 0.0164488799196185 WAS/NCKAP1L 2 BP GO:0071216 cellular response to biotic stimulus 2/17 195/17381 0.015245656123384 0.0428648900887315 0.0180307837656509 BTK/CCR5 2 BP GO:0030889 negative regulation of B cell proliferation 1/17 16/17381 0.0155416560555635 0.0428648900887315 0.0180307837656509 BTK 1 BP GO:0032515 negative regulation of phosphoprotein phosphatase activity 1/17 16/17381 0.0155416560555635 0.0428648900887315 0.0180307837656509 NCKAP1L 1 BP GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 1/17 16/17381 0.0155416560555635 0.0428648900887315 0.0180307837656509 WAS 1 BP GO:0036037 CD8-positive, alpha-beta T cell activation 1/17 16/17381 0.0155416560555635 0.0428648900887315 0.0180307837656509 NCKAP1L 1 BP GO:0030595 leukocyte chemotaxis 2/17 203/17381 0.016450136891052 0.0445646388125639 0.0187457698914037 NCKAP1L/CCR5 2 BP GO:0002577 regulation of antigen processing and presentation 1/17 17/17381 0.0165054217824311 0.0445646388125639 0.0187457698914037 WAS 1 BP GO:0002643 regulation of tolerance induction 1/17 17/17381 0.0165054217824311 0.0445646388125639 0.0187457698914037 CD3E 1 BP GO:0033630 positive regulation of cell adhesion mediated by integrin 1/17 17/17381 0.0165054217824311 0.0445646388125639 0.0187457698914037 NCKAP1L 1 BP GO:0051495 positive regulation of cytoskeleton organization 2/17 205/17381 0.0167575028449411 0.04500837151547 0.0189324226134633 WAS/NCKAP1L 2 BP GO:0051701 interaction with host 2/17 209/17381 0.0173796618171681 0.0456667439561042 0.0192093618775036 CD4/CCR5 2 BP GO:0002902 regulation of B cell apoptotic process 1/17 18/17381 0.0174682994505779 0.0456667439561042 0.0192093618775036 BTK 1 BP GO:0030011 maintenance of cell polarity 1/17 18/17381 0.0174682994505779 0.0456667439561042 0.0192093618775036 NCKAP1L 1 BP GO:0033622 integrin activation 1/17 18/17381 0.0174682994505779 0.0456667439561042 0.0192093618775036 FERMT3 1 BP GO:0045655 regulation of monocyte differentiation 1/17 18/17381 0.0174682994505779 0.0456667439561042 0.0192093618775036 CD4 1 BP GO:2000021 regulation of ion homeostasis 2/17 210/17381 0.0175367418310965 0.0456667439561042 0.0192093618775036 CD4/CCR5 2 BP GO:0030100 regulation of endocytosis 2/17 214/17381 0.0181711869200676 0.0470798933838116 0.0198037922308021 DOCK2/NCKAP1L 2 BP GO:0006907 pinocytosis 1/17 19/17381 0.0184302898272032 0.0475112496550514 0.0199852389028122 DOCK2 1 BP GO:0002440 production of molecular mediator of immune response 2/17 218/17381 0.0188153746189667 0.0482614358976497 0.0203007989309904 BTK/SASH3 2 BP GO:0045117 azole transport 1/17 20/17381 0.0193913936788866 0.0494441301898627 0.0207982901178247 BTK 1 BP GO:0032846 positive regulation of homeostatic process 2/17 222/17381 0.0194692286517588 0.0494441301898627 0.0207982901178247 CD4/NCKAP1L 2 CC GO:0098552 side of membrane 5/18 482/18511 7.58595727958026e-05 0.00423432629964041 0.00262655578737093 CD3E/BTK/RASAL3/CD4/CCR5 5 CC GO:0042101 T cell receptor complex 2/18 19/18511 0.000151225939272872 0.00423432629964041 0.00262655578737093 CD3E/CD4 2 CC GO:0098802 plasma membrane receptor complex 3/18 177/18511 0.000631014746974147 0.0117789419435174 0.00730648654391118 CD3E/ITGAL/CD4 3 CC GO:0009897 external side of plasma membrane 3/18 270/18511 0.0021291209939011 0.0283509496750171 0.0175861153999166 CD3E/CD4/CCR5 3 CC GO:0034774 secretory granule lumen 3/18 321/18511 0.00347474993187949 0.0283509496750171 0.0175861153999166 DOCK2/FERMT3/ARHGAP9 3 CC GO:0043235 receptor complex 3/18 325/18511 0.00359792555388228 0.0283509496750171 0.0175861153999166 CD3E/ITGAL/CD4 3 CC GO:0060205 cytoplasmic vesicle lumen 3/18 338/18511 0.0040167360314724 0.0283509496750171 0.0175861153999166 DOCK2/FERMT3/ARHGAP9 3 CC GO:0031983 vesicle lumen 3/18 339/18511 0.00405013566785959 0.0283509496750171 0.0175861153999166 DOCK2/FERMT3/ARHGAP9 3 MF GO:0030695 GTPase regulator activity 5/16 313/17354 6.85879992621216e-06 0.000318510286149149 0.000155219437694517 WAS/DOCK2/ARHGAP9/RASAL3/NCKAP1L 5 MF GO:0060589 nucleoside-triphosphatase regulator activity 5/16 350/17354 1.17966772647833e-05 0.000318510286149149 0.000155219437694517 WAS/DOCK2/ARHGAP9/RASAL3/NCKAP1L 5 MF GO:0005096 GTPase activator activity 4/16 284/17354 0.000109433261542018 0.00196979870775632 0.000959940890719456 DOCK2/ARHGAP9/RASAL3/NCKAP1L 4 MF GO:1901981 phosphatidylinositol phosphate binding 3/16 135/17354 0.000239394726264903 0.0032318288045762 0.00157496530437436 ARHGAP9/BTK/SNX20 3 MF GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/16 37/17354 0.000520878591092741 0.00548149495875526 0.00267129383954935 ARHGAP9/BTK 2 MF GO:0015026 coreceptor activity 2/16 40/17354 0.000609054995417251 0.00548149495875526 0.00267129383954935 CD4/CCR5 2 MF GO:0035091 phosphatidylinositol binding 3/16 221/17354 0.00100939536458959 0.00778676424111967 0.00379471941575033 ARHGAP9/BTK/SNX20 3 MF GO:0048365 Rac GTPase binding 2/16 64/17354 0.00155400117054118 0.010489507901153 0.00511184595572757 WAS/DOCK2 2 MF GO:0001618 virus receptor activity 2/16 73/17354 0.00201598192247767 0.0108863023813794 0.00530521558546755 CD4/CCR5 2 MF GO:0104005 hijacked molecular function 2/16 73/17354 0.00201598192247767 0.0108863023813794 0.00530521558546755 CD4/CCR5 2 MF GO:0004896 cytokine receptor activity 2/16 91/17354 0.00311112552681377 0.0152727980407221 0.00744288403543964 CD4/CCR5 2 MF GO:0019955 cytokine binding 2/16 101/17354 0.00381613576700575 0.0171726109515259 0.00836871878729331 CD4/CCR5 2 MF GO:0005543 phospholipid binding 3/16 375/17354 0.00454716613430807 0.0188882285578951 0.0092047897455629 ARHGAP9/BTK/SNX20 3 MF GO:0003779 actin binding 3/16 403/17354 0.00555842185661881 0.0208134585693142 0.0101430109986911 WAS/MYO1F/CCR5 3 MF GO:0017124 SH3 domain binding 2/16 125/17354 0.00578151626925394 0.0208134585693142 0.0101430109986911 WAS/CD3E 2 MF GO:0017048 Rho GTPase binding 2/16 161/17354 0.00942483931037672 0.0318088326725214 0.0155013804446986 WAS/DOCK2 2 MF GO:0016493 C-C chemokine receptor activity 1/16 12/17354 0.0110112735002845 0.0349769864126685 0.0170453150159203 CCR5 1 MF GO:0043274 phospholipase binding 1/16 14/17354 0.0128353971084082 0.0385061913252246 0.0187652004508892 WAS 1 MF GO:0030676 Rac guanyl-nucleotide exchange factor activity 1/16 15/17354 0.0137462756347209 0.0390683623302593 0.0190391629289763 DOCK2 1