ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count hsa04060 Cytokine-cytokine receptor interaction 45/485 294/7482 3.9842888818319e-08 1.1235694646766e-05 1.01494516779297e-05 3624/3590/9518/2921/6387/3570/6359/2919/1271/3557/6374/51561/3589/650/3603/53832/2690/6372/11009/3587/1437/10344/6373/8771/4982/653/6363/5008/651/8742/10913/3952/3598/2920/5196/4050/3552/3553/5473/608/5197/56477/6347/9547/6364 45 hsa00040 Pentose and glucuronate interconversions 12/485 34/7482 7.08329132107557e-07 9.98744076271655e-05 9.02187631421204e-05 7360/231/6652/57016/7358/54578/10720/7365/79799/7366/54576/7367 12 hsa04978 Mineral absorption 13/485 51/7482 1.48141098049049e-05 0.00139252632166106 0.0012578998501007 477/4499/4493/4489/4496/4490/4501/4495/6546/4494/1811/4502/6523 13 hsa00053 Ascorbate and aldarate metabolism 9/485 27/7482 3.06682616774431e-05 0.00216211244825974 0.00195308403314243 7358/54578/10720/7365/79799/7366/54576/9104/7367 9 hsa00982 Drug metabolism - cytochrome P450 14/485 72/7482 0.00017511334125505 0.00987639244678482 0.00892156391236255 2946/4129/4128/119391/126/54578/10720/7365/2330/124/79799/7366/54576/7367 14 hsa04657 IL-17 signaling pathway 16/485 93/7482 0.000275133359906121 0.0122250826701657 0.0110431877796943 2921/4314/4312/2919/6374/3727/6372/2354/5596/1437/2353/2920/4322/3553/6347/6364 16 hsa00830 Retinol metabolism 13/485 67/7482 0.000303459498904822 0.0122250826701657 0.0110431877796943 5959/54884/10170/126/216/54578/10720/7365/124/79799/7366/54576/7367 13 hsa05323 Rheumatoid arthritis 15/485 90/7482 0.000602004665254378 0.0212206644502168 0.019169095919942 4314/6387/4312/2919/6374/51561/3589/6372/1437/2353/4050/3552/3553/6347/6364 15 hsa05204 Chemical carcinogenesis 14/485 82/7482 0.000708802539486855 0.0222091462372548 0.0200620133983414 2946/6799/6817/445329/119391/126/54578/10720/7365/124/79799/7366/54576/7367 14 hsa00140 Steroid hormone biosynthesis 11/485 60/7482 0.00142625334206215 0.0396664111219951 0.0358315471874685 6820/3294/3284/54578/3291/10720/7365/79799/7366/54576/7367 11 hsa00983 Drug metabolism - other enzymes 13/485 79/7482 0.0015472713558225 0.0396664111219951 0.0358315471874685 3251/2946/6241/119391/8824/54578/1066/10720/7365/79799/7366/54576/7367 13 hsa04062 Chemokine signaling pathway 23/485 190/7482 0.00264018625302083 0.0620443769459895 0.0560460590553545 2788/2921/6387/5906/10235/6359/2919/54331/111/6374/2770/6372/10344/6373/6363/2920/5196/5473/5197/56477/6347/9547/6364 23 hsa00910 Nitrogen metabolism 5/485 17/7482 0.00361215736776666 0.0783560290546306 0.0707807354655491 23632/759/762/760/771 5 hsa04022 cGMP-PKG signaling pathway 20/485 163/7482 0.00419043730726538 0.0844073800463456 0.0762470547637761 477/5138/2767/3778/4638/493/5139/154/291/111/10398/3708/2770/10242/4208/4772/6546/84699/5350/5997 20 hsa04976 Bile secretion 11/485 71/7482 0.00559997131560165 0.105279460733311 0.095101267254428 477/343/9429/760/111/9971/8671/366/5243/6523/28234 11 hsa05134 Legionellosis 9/485 55/7482 0.00822782569495858 0.140646273041934 0.12704889166162 2921/2919/3329/3306/3303/840/718/2920/3553 9 hsa04972 Pancreatic secretion 13/485 96/7482 0.00867409150327976 0.140646273041934 0.12704889166162 477/5906/3778/493/760/6558/111/3708/22802/8671/1811/7220/1179 13 hsa00980 Metabolism of xenobiotics by cytochrome P450 11/485 76/7482 0.00936300884359959 0.140646273041934 0.12704889166162 2946/119391/126/54578/10720/7365/124/79799/7366/54576/7367 11 hsa04024 cAMP signaling pathway 22/485 199/7482 0.00947616733261257 0.140646273041934 0.12704889166162 5348/477/6662/5906/493/1261/5139/154/4852/111/51196/10398/2770/6752/4772/2353/7137/84699/4886/2737/2892/5350 22 hsa05414 Dilated cardiomyopathy (DCM) 12/485 90/7482 0.012876128950704 0.181553418204926 0.164001221372124 6445/7169/1674/111/3679/3696/6546/7137/3673/6442/3479/5350 12 hsa04115 p53 signaling pathway 10/485 72/7482 0.0170145506969553 0.220015750440582 0.198745097449126 637/1111/891/9133/5366/6241/64065/5268/4616/3479 10 hsa00860 Porphyrin and chlorophyll metabolism 7/485 42/7482 0.0171643493251518 0.220015750440582 0.198745097449126 54578/10720/7365/79799/7366/54576/7367 7 hsa04713 Circadian entrainment 12/485 96/7482 0.0207094284491111 0.250336024553489 0.226134072198374 2788/5187/8863/6261/9252/54331/6263/111/3708/2770/2353/2892 12 hsa04640 Hematopoietic cell lineage 12/485 97/7482 0.0222997239392727 0.250336024553489 0.226134072198374 3590/3570/290/3589/1437/1380/3673/930/931/3552/3815/3553 12 hsa05133 Pertussis 10/485 76/7482 0.0240832901799151 0.250336024553489 0.226134072198374 1073/6374/51561/2770/6372/840/2353/718/3552/3553 10 hsa04270 Vascular smooth muscle contraction 14/485 121/7482 0.0242835669972344 0.250336024553489 0.226134072198374 4637/54776/2767/94274/3778/72/4638/4660/111/10398/3708/10242/800/10267 14 hsa04360 Axon guidance 19/485 181/7482 0.0249893984098244 0.250336024553489 0.226134072198374 9423/6387/4233/2048/2045/57556/6586/3611/7869/1073/10398/9723/2770/80031/7474/2049/9353/5336/7220 19 hsa04668 TNF signaling pathway 13/485 110/7482 0.0251033908956701 0.250336024553489 0.226134072198374 2921/4314/2919/9252/6374/1437/840/2353/84699/2920/3553/6347/6364 13 hsa00350 Tyrosine metabolism 6/485 36/7482 0.026598323521458 0.250336024553489 0.226134072198374 8639/4129/4128/126/124/7173 6 hsa04310 Wnt signaling pathway 17/485 158/7482 0.0266314919737754 0.250336024553489 0.226134072198374 4316/340419/6422/85409/7472/54894/4772/7474/59352/8549/8322/166336/27121/4919/6423/11211/6424 17 hsa04960 Aldosterone-regulated sodium reabsorption 6/485 37/7482 0.0300715248011071 0.258736520408985 0.233722426050669 477/6446/6338/3291/4306/3479 6 hsa04970 Salivary secretion 11/485 90/7482 0.0302776779202003 0.258736520408985 0.233722426050669 477/3778/493/154/6558/6263/111/3708/1469/54831/3783 11 hsa04974 Protein digestion and absorption 11/485 90/7482 0.0302776779202003 0.258736520408985 0.233722426050669 477/10008/1301/1300/117247/4225/6546/3783/1291/1292/4224 11 hsa05202 Transcriptional misregulation in cancer 19/485 186/7482 0.0320024538360258 0.265432117110567 0.239770706759079 4314/7704/4233/7102/861/2118/5087/4208/3002/3248/1437/5328/4211/4616/5090/8091/2892/3479/8013 19 hsa05205 Proteoglycans in cancer 20/485 201/7482 0.0360297062599106 0.290296490436994 0.262231245560853 54776/4233/2318/288/4660/27250/2316/51196/7472/2260/3708/857/7474/5328/3673/8322/5336/3479/1634/11211 20 hsa05030 Cocaine addiction 7/485 49/7482 0.0371229332584975 0.290796310524897 0.262682744109836 8787/111/2770/4129/2354/4128/84699 7 hsa04928 Parathyroid hormone synthesis, secretion and action 12/485 106/7482 0.0408955257874097 0.30530018850885 0.275784418137894 2767/111/2260/3708/2770/3727/4208/9368/2353/84699/4322/1958 12 hsa05410 Hypertrophic cardiomyopathy (HCM) 10/485 83/7482 0.0411688930253759 0.30530018850885 0.275784418137894 6445/7169/1674/3679/3696/6546/7137/3673/6442/3479 10 hsa00260 Glycine, serine and threonine metabolism 6/485 40/7482 0.0422223664959048 0.30530018850885 0.275784418137894 8639/1610/4129/29968/4128/29958 6 hsa04530 Tight junction 17/485 170/7482 0.048571897963711 0.341912768436774 0.308857372010822 9076/4637/5906/861/23370/4621/58494/83700/10398/137075/9368/8777/23562/79861/9075/57530/9073 17 hsa04971 Gastric acid secretion 9/485 75/7482 0.0522860406061655 0.341912768436774 0.308857372010822 477/4638/760/111/6750/3708/2770/6752/9992 9 hsa04914 Progesterone-mediated oocyte maturation 11/485 99/7482 0.0547761901868397 0.341912768436774 0.308857372010822 891/64506/699/995/4085/9133/111/2770/5241/890/3479 11 hsa04933 AGE-RAGE signaling pathway in diabetic complications 11/485 99/7482 0.0547761901868397 0.341912768436774 0.308857372010822 84812/5333/51196/4772/5336/3552/50507/3553/1958/6347/27035 11 hsa04924 Renin secretion 8/485 65/7482 0.0576241186942922 0.341912768436774 0.308857372010822 3778/5139/154/111/3708/2770/22802/1179 8 hsa04110 Cell cycle 13/485 124/7482 0.0576341497307136 0.341912768436774 0.308857372010822 1111/891/699/10744/995/990/7272/4085/9133/10926/4173/890/4616 13 hsa04964 Proximal tubule bicarbonate reclamation 4/485 23/7482 0.0578647845461102 0.341912768436774 0.308857372010822 477/762/760/8671 4 hsa04670 Leukocyte transendothelial migration 12/485 112/7482 0.0581105603546785 0.341912768436774 0.308857372010822 9076/6387/5906/58494/83700/10398/2770/137075/23562/5336/9075/9073 12 hsa04923 Regulation of lipolysis in adipocytes 7/485 54/7482 0.0581979180317913 0.341912768436774 0.308857372010822 11343/5742/154/4852/111/2770/4886 7 hsa04610 Complement and coagulation cascades 9/485 79/7482 0.0684871893828468 0.394150763386996 0.356045109143908 1675/1191/2161/730/623/1380/5328/2/718 9 hsa05020 Prion diseases 5/485 35/7482 0.0729932979761048 0.411682200585231 0.371881644425629 730/3303/3552/3553/1958 5 hsa04730 Long-term depression 7/485 60/7482 0.0916118483959797 0.496582777517902 0.448574214853798 2767/6261/3708/2770/2781/2892/3479 7 hsa00360 Phenylalanine metabolism 3/485 17/7482 0.093504240606193 0.496582777517902 0.448574214853798 8639/4129/4128 3 hsa04510 Focal adhesion 18/485 199/7482 0.0938664649395775 0.496582777517902 0.448574214853798 54776/4233/5906/2318/4638/4660/3611/2316/10398/3679/857/3696/3673/6696/1291/1292/3479/7060 18 hsa05144 Malaria 6/485 49/7482 0.0950903190991728 0.496582777517902 0.448574214853798 4233/3039/3040/3553/6347/7060 6 hsa04911 Insulin secretion 9/485 85/7482 0.0981076516608292 0.503024686697342 0.454393334008051 477/2767/3778/111/10242/6616/2641/84699/3783 9 hsa05132 Salmonella infection 9/485 86/7482 0.103666657757321 0.522035669420796 0.471566375512627 2921/2318/2919/2316/1437/2353/2920/3552/3553 9 hsa04371 Apelin signaling pathway 13/485 137/7482 0.106358399677117 0.526194187876262 0.475322857282775 2788/6261/4638/54331/6263/8862/111/3708/2770/4208/6546/6696/1958 13 hsa04114 Oocyte meiosis 12/485 125/7482 0.110320768147873 0.533582894963663 0.481997239944779 891/64506/699/10744/995/4085/9133/111/3708/5241/367/3479 12 hsa05217 Basal cell carcinoma 7/485 63/7482 0.111636137598781 0.533582894963663 0.481997239944779 7472/650/7474/8322/4616/2737/11211 7 hsa04921 Oxytocin signaling pathway 14/485 152/7482 0.115395641780285 0.54235951636734 0.489925356330334 4637/54776/6261/4638/4660/6263/111/10398/3708/2770/4208/4772/2353/5997 14 hsa04726 Serotonergic synapse 11/485 115/7482 0.124916305431731 0.577481936586033 0.521652215953042 2788/5742/54331/111/3708/2770/4129/4128/1843/7220/260293 11 hsa00230 Purine metabolism 12/485 130/7482 0.135973003409764 0.617752888434501 0.558029858160318 5471/3251/5152/5138/5139/111/6241/5158/957/9060/5145/270 12 hsa00052 Galactose metabolism 4/485 31/7482 0.138008624011963 0.617752888434501 0.558029858160318 7360/231/57016/6476 4 hsa04261 Adrenergic signaling in cardiomyocytes 13/485 144/7482 0.140472285269831 0.618956006970194 0.559116661764789 477/6330/7169/493/9252/154/111/2770/6332/6546/7137/84699/5350 13 hsa04940 Type I diabetes mellitus 5/485 43/7482 0.143347594456061 0.621908025178604 0.561783285155738 3329/3002/3552/3553/1363 5 hsa05031 Amphetamine addiction 7/485 68/7482 0.149651487445811 0.628141802032553 0.56741439377334 111/4129/2354/4128/2353/84699/2892 7 hsa00480 Glutathione metabolism 6/485 56/7482 0.152758672110844 0.628141802032553 0.56741439377334 2946/290/6241/2878/2877/119391 6 hsa00071 Fatty acid degradation 5/485 44/7482 0.153694270710093 0.628141802032553 0.56741439377334 37/35/10449/126/124 5 hsa02010 ABC transporters 5/485 44/7482 0.153694270710093 0.628141802032553 0.56741439377334 10351/9429/10350/23460/5243 5 hsa04020 Calcium signaling pathway 16/485 188/7482 0.159390070994049 0.628520546584891 0.567756522111025 84812/5333/2767/6261/4638/493/154/291/6263/51196/3708/623/6546/5336/3706/5350 16 hsa04512 ECM-receptor interaction 8/485 82/7482 0.160468605154875 0.628520546584891 0.567756522111025 3161/3679/3696/3673/6696/1291/1292/7060 8 hsa04064 NF-kappa B signaling pathway 9/485 95/7482 0.161367469265403 0.628520546584891 0.567756522111025 6387/79092/5328/6363/4616/5336/2920/4050/3553 9 hsa04215 Apoptosis - multiple species 4/485 33/7482 0.162702127307436 0.628520546584891 0.567756522111025 637/332/5366/840 4 hsa04630 JAK-STAT signaling pathway 14/485 162/7482 0.165313990400246 0.629980341795532 0.569075187437547 3590/2273/3570/1271/51561/3589/53832/2690/11009/3587/1437/5008/3952/3598 14 hsa04210 Apoptosis 12/485 136/7482 0.170658121190252 0.641674535675347 0.579638811621628 84823/637/332/5366/3708/3002/8722/840/2353/4001/4616/79861 12 hsa04915 Estrogen signaling pathway 12/485 137/7482 0.176830894455513 0.656135687321771 0.592701890003242 192666/25984/111/3708/2770/5241/3306/3303/2353/84699/3872/3859 12 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/485 72/7482 0.183863258542292 0.665634699178611 0.601282557675341 6445/1674/3679/3696/6546/3673/6442 7 hsa00340 Histidine metabolism 3/485 23/7482 0.184186859932912 0.665634699178611 0.601282557675341 443/4129/4128 3 hsa00270 Cysteine and methionine metabolism 5/485 47/7482 0.186472132039398 0.665634699178611 0.601282557675341 191/23743/7263/23382/1036 5 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 3/485 24/7482 0.201066738889756 0.685933618822634 0.619619021108912 266722/90161/222537 3 hsa03320 PPAR signaling pathway 7/485 74/7482 0.202087892977345 0.685933618822634 0.619619021108912 4312/2172/3611/6319/10580/2168/4973 7 hsa04918 Thyroid hormone synthesis 7/485 74/7482 0.202087892977345 0.685933618822634 0.619619021108912 477/111/3708/2878/2877/84699/7173 7 hsa00500 Starch and sucrose metabolism 4/485 36/7482 0.202395014417034 0.685933618822634 0.619619021108912 7360/5837/57733/6476 4 hsa04010 MAPK signaling pathway 23/485 295/7482 0.204320652415253 0.685933618822634 0.619619021108912 4233/5906/2318/10235/2316/9252/2263/2260/3306/3727/4208/4772/3315/3303/285/2353/4616/1843/3479/3552/2069/3815/3553 23 hsa04672 Intestinal immune network for IgA production 5/485 49/7482 0.209608842149189 0.694630381024621 0.627474998909885 6387/57379/608/5284/56477 5 hsa04213 Longevity regulating pathway - multiple species 6/485 62/7482 0.211837633929494 0.694630381024621 0.627474998909885 111/1410/3306/3303/3170/3479 6 hsa00330 Arginine and proline metabolism 5/485 50/7482 0.221511428076312 0.704149312516612 0.63607366042934 1610/1152/4129/4128/283208 5 hsa00590 Arachidonic acid metabolism 6/485 63/7482 0.222385159859043 0.704149312516612 0.63607366042934 5742/2053/5730/2878/2877/11283 6 hsa04514 Cell adhesion molecules (CAMs) 12/485 144/7482 0.222893491715588 0.704149312516612 0.63607366042934 1001/9076/9378/58494/83700/22871/137075/3696/257194/23562/9075/9073 12 hsa05167 Kaposi sarcoma-associated herpesvirus infection 15/485 186/7482 0.224728503994663 0.704149312516612 0.63607366042934 2788/637/2921/2919/54331/3708/4772/1437/7538/285/2353/718/5336/7098/2920 15 hsa04728 Dopaminergic synapse 11/485 131/7482 0.22846313556977 0.707984661875551 0.639538216401207 2788/54331/111/3708/2770/4129/4128/3800/2353/84699/2892 11 hsa04927 Cortisol synthesis and secretion 6/485 64/7482 0.233102259214652 0.714509098897086 0.645431884781989 2767/111/3708/5087/3284/84699 6 hsa00790 Folate biosynthesis 3/485 26/7482 0.235802993281539 0.71501552801499 0.645889353414064 231/57016/8836 3 hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 2/485 15/7482 0.253540768528927 0.744796794530452 0.672791430669538 2523/6489 2 hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/485 15/7482 0.253540768528927 0.744796794530452 0.672791430669538 30815/6489 2 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 3/485 27/7482 0.253547844946537 0.744796794530452 0.672791430669538 2651/2523/6489 3 hsa04744 Phototransduction 3/485 28/7482 0.271473215665897 0.788201436152305 0.711999804213728 8787/5158/5145 3 hsa04611 Platelet activation 10/485 123/7482 0.274522067307191 0.788201436152305 0.711999804213728 5906/10235/4638/5742/111/3708/2770/5028/3673/5336 10 hsa05120 Epithelial cell signaling in Helicobacter pylori infection 6/485 68/7482 0.277424218925696 0.788201436152305 0.711999804213728 4233/2919/58494/83700/5803/5336 6 hsa04151 PI3K-Akt signaling pathway 26/485 354/7482 0.279504055373158 0.788201436152305 0.711999804213728 2788/3570/4233/1902/6446/54331/2263/2260/3679/8115/2690/3696/285/9863/5008/84699/3673/6696/930/1291/1292/3479/10110/2069/3815/7060 26 hsa04925 Aldosterone synthesis and secretion 8/485 96/7482 0.28262091977826 0.789099993836331 0.712811491259396 477/5138/2767/493/111/3708/3284/84699 8 hsa05418 Fluid shear stress and atherosclerosis 11/485 139/7482 0.28997143083048 0.801685720531326 0.724180456769619 2946/4880/857/4208/2353/119391/1843/3552/3553/6347/27035 11 hsa04934 Cushing syndrome 12/485 154/7482 0.295949086719341 0.810268373348099 0.731933357037103 2767/5906/111/7472/3708/2770/5087/3284/7474/84699/8322/11211 12 hsa04725 Cholinergic synapse 9/485 112/7482 0.30110223927455 0.816450302648299 0.737517630611752 2788/2767/54331/111/3708/2770/2353/84699/1136 9 hsa00512 Mucin type O-glycan biosynthesis 3/485 31/7482 0.325846257995009 0.862694297808666 0.779290855056727 11227/11226/2591 3 hsa01523 Antifolate resistance 3/485 31/7482 0.325846257995009 0.862694297808666 0.779290855056727 9429/8836/3553 3 hsa00511 Other glycan degradation 2/485 18/7482 0.327334361225274 0.862694297808666 0.779290855056727 2517/57704 2 hsa04916 Melanogenesis 8/485 101/7482 0.33127466759277 0.864696805367858 0.7810997644607 111/7472/2770/7474/84699/8322/3815/11211 8 hsa04926 Relaxin signaling pathway 10/485 130/7482 0.334226779379775 0.864696805367858 0.7810997644607 2788/4312/54331/111/2770/2353/84699/10022/4322/6019 10 hsa04919 Thyroid hormone signaling pathway 9/485 116/7482 0.337780624110053 0.865946690900317 0.782228813728543 477/84812/5333/1734/10231/51196/117247/5336/5350 9 hsa04540 Gap junction 7/485 88/7482 0.34430564408205 0.873500824785215 0.78905263007847 2767/1902/111/3708/2770/84617/79861 7 hsa00562 Inositol phosphate metabolism 6/485 74/7482 0.346922313389873 0.873500824785215 0.78905263007847 84812/5333/3632/51196/5336/3706 6 hsa04015 Rap1 signaling pathway 15/485 206/7482 0.357953751152861 0.888061130371228 0.8022052764085 1268/4233/5906/10235/1902/111/51196/2263/2260/2770/285/9863/5028/3479/3815 15 hsa00561 Glycerolipid metabolism 5/485 61/7482 0.361735840133909 0.888061130371228 0.8022052764085 231/11343/57016/80168/3990 5 hsa00051 Fructose and mannose metabolism 3/485 33/7482 0.362152588626564 0.888061130371228 0.8022052764085 231/6652/57016 3 hsa04913 Ovarian steroidogenesis 4/485 49/7482 0.393542150249618 0.949765907389573 0.857944567332126 111/3294/3284/3479 4 hsa00250 Alanine, aspartate and glutamate metabolism 3/485 35/7482 0.398145000436755 0.949765907389573 0.857944567332126 5471/443/2875 3 hsa05143 African trypanosomiasis 3/485 35/7482 0.398145000436755 0.949765907389573 0.857944567332126 3039/3040/3553 3 hsa05170 Human immunodeficiency virus 1 infection 15/485 212/7482 0.400787741061557 0.949765907389573 0.857944567332126 2788/637/1111/891/2767/995/9133/54331/1073/3708/2770/4772/2353/5336/8905 15 hsa04810 Regulation of actin cytoskeleton 15/485 213/7482 0.407978469679915 0.958749403747799 0.866059558443327 2934/54776/6387/4638/4660/1902/1073/2263/10398/2260/3679/623/3696/3673/85477 15 hsa04550 Signaling pathways regulating pluripotency of stem cells 10/485 139/7482 0.413871186839383 0.964559294947983 0.871307761767122 3624/9314/2263/7472/2260/7474/4211/8322/3479/11211 10 hsa05215 Prostate cancer 7/485 97/7482 0.441560038276618 0.999999998067058 0.903322133378977 4314/2263/2260/367/5328/84699/3479 7 hsa04614 Renin-angiotensin system 2/485 23/7482 0.444863914051137 0.999999998067058 0.903322133378977 290/1511 2 hsa04380 Osteoclast differentiation 9/485 128/7482 0.450511524383589 0.999999998067058 0.903322133378977 3727/4772/2354/4982/2353/5336/3552/3553/27035 9 hsa05166 Human T-cell leukemia virus 1 infection 15/485 219/7482 0.451211381416378 0.999999998067058 0.903322133378977 4316/1111/10744/4085/9133/4488/291/111/4772/890/1437/7538/2353/84699/1958 15 hsa01212 Fatty acid metabolism 4/485 53/7482 0.452856213406484 0.999999998067058 0.903322133378977 37/6319/35/10449 4 hsa04724 Glutamatergic synapse 8/485 114/7482 0.461438628529409 0.999999998067058 0.903322133378977 2788/54331/111/3708/2770/2918/7220/2892 8 hsa04070 Phosphatidylinositol signaling system 7/485 99/7482 0.463009667603478 0.999999998067058 0.903322133378977 84812/5333/3632/51196/3708/5336/3706 7 hsa05224 Breast cancer 10/485 147/7482 0.484833548218871 0.999999998067058 0.903322133378977 7472/2260/5241/7474/2353/8322/4616/3479/3815/11211 10 hsa04662 B cell receptor signaling pathway 5/485 71/7482 0.491489196788501 0.999999998067058 0.903322133378977 4772/1380/2353/930/5336 5 hsa05332 Graft-versus-host disease 3/485 41/7482 0.501835833202825 0.999999998067058 0.903322133378977 3002/3552/3553 3 hsa04950 Maturity onset diabetes of the young 2/485 26/7482 0.50972765997765 0.999999998067058 0.903322133378977 3110/3170 2 hsa01524 Platinum drug resistance 5/485 73/7482 0.516442194984198 0.999999998067058 0.903322133378977 637/2946/332/5366/119391 5 hsa00430 Taurine and hypotaurine metabolism 1/485 11/7482 0.521794719480144 0.999999998067058 0.903322133378977 1036 1 hsa05225 Hepatocellular carcinoma 11/485 168/7482 0.531710506352778 0.999999998067058 0.903322133378977 2946/4233/8110/7472/7474/119391/6604/8322/4616/5336/11211 11 hsa04080 Neuroactive ligand-receptor interaction 18/485 277/7482 0.531861093289225 0.999999998067058 0.903322133378977 9340/1268/1902/154/1511/6752/2690/2908/623/5028/4886/3952/2918/9934/2892/7433/4887/1136 18 hsa05416 Viral myocarditis 4/485 59/7482 0.537785703254036 0.999999998067058 0.903322133378977 6445/637/857/6442 4 hsa05032 Morphine addiction 6/485 91/7482 0.543729997742805 0.999999998067058 0.903322133378977 2788/5138/5139/54331/111/2770 6 hsa04973 Carbohydrate digestion and absorption 3/485 44/7482 0.550171001187029 0.999999998067058 0.903322133378977 477/6523/6476 3 hsa04392 Hippo signaling pathway - multiple species 2/485 29/7482 0.569429254321411 0.999999998067058 0.903322133378977 7004/9770 2 hsa04260 Cardiac muscle contraction 5/485 78/7482 0.5763937537268 0.999999998067058 0.903322133378977 477/7169/6546/7137/4512 5 hsa01521 EGFR tyrosine kinase inhibitor resistance 5/485 79/7482 0.58790928247929 0.999999998067058 0.903322133378977 3570/4233/2263/5336/3479 5 hsa05146 Amoebiasis 6/485 96/7482 0.596972955000249 0.999999998067058 0.903322133378977 2767/2919/1511/3315/1437/3553 6 hsa05163 Human cytomegalovirus infection 14/485 225/7482 0.603850085880744 0.999999998067058 0.903322133378977 2788/637/6387/3570/2767/54331/111/3708/2770/4772/3587/84699/3553/6347 14 hsa04710 Circadian rhythm 2/485 31/7482 0.606214746156896 0.999999998067058 0.903322133378977 5187/8863 2 hsa05230 Central carbon metabolism in cancer 4/485 65/7482 0.615556541658373 0.999999998067058 0.903322133378977 4233/2263/2260/3815 4 hsa05321 Inflammatory bowel disease (IBD) 4/485 65/7482 0.615556541658373 0.999999998067058 0.903322133378977 51561/4772/3552/3553 4 hsa04750 Inflammatory mediator regulation of TRP channels 6/485 99/7482 0.627278820195948 0.999999998067058 0.903322133378977 111/3708/623/5336/3479/3553 6 hsa05221 Acute myeloid leukemia 4/485 66/7482 0.627701228953176 0.999999998067058 0.903322133378977 7704/861/1437/3815 4 hsa05110 Vibrio cholerae infection 3/485 50/7482 0.63800022261786 0.999999998067058 0.903322133378977 11015/6558/5336 3 hsa05014 Amyotrophic lateral sclerosis (ALS) 3/485 51/7482 0.651413647755724 0.999999998067058 0.903322133378977 637/5630/4741 3 hsa05142 Chagas disease (American trypanosomiasis) 6/485 102/7482 0.656230206898872 0.999999998067058 0.903322133378977 2767/2770/2353/718/3553/6347 6 hsa05210 Colorectal cancer 5/485 86/7482 0.66344915004978 0.999999998067058 0.903322133378977 332/5366/2353/4616/2069 5 hsa04625 C-type lectin receptor signaling pathway 6/485 104/7482 0.674742459177038 0.999999998067058 0.903322133378977 51561/3708/4772/4046/5336/3553 6 hsa00120 Primary bile acid biosynthesis 1/485 17/7482 0.680366072981965 0.999999998067058 0.903322133378977 51302 1 hsa00450 Selenocompound metabolism 1/485 17/7482 0.680366072981965 0.999999998067058 0.903322133378977 9060 1 hsa03030 DNA replication 2/485 36/7482 0.687612072133836 0.999999998067058 0.903322133378977 4173/1763 2 hsa05218 Melanoma 4/485 72/7482 0.695289459919173 0.999999998067058 0.903322133378977 4233/2260/4616/3479 4 hsa01210 2-Oxocarboxylic acid metabolism 1/485 18/7482 0.70113264426177 0.999999998067058 0.903322133378977 2875 1 hsa04659 Th17 cell differentiation 6/485 107/7482 0.701289997054883 0.999999998067058 0.903322133378977 3570/861/51561/4772/2353/3553 6 hsa05130 Pathogenic Escherichia coli infection 3/485 55/7482 0.701486090974277 0.999999998067058 0.903322133378977 9076/84617/79861 3 hsa05340 Primary immunodeficiency 2/485 37/7482 0.702129162645146 0.999999998067058 0.903322133378977 930/57379 2 hsa05140 Leishmaniasis 4/485 74/7482 0.715767770045657 0.999999998067058 0.903322133378977 2353/718/3552/3553 4 hsa04218 Cellular senescence 9/485 160/7482 0.718368107231399 0.999999998067058 0.903322133378977 1111/891/9133/291/3708/4772/890/4616/3552 9 hsa00100 Steroid biosynthesis 1/485 19/7482 0.720552615796208 0.999999998067058 0.903322133378977 6713 1 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/485 20/7482 0.738713138553657 0.999999998067058 0.903322133378977 10090 1 hsa00670 One carbon pool by folate 1/485 20/7482 0.738713138553657 0.999999998067058 0.903322133378977 10797 1 hsa05034 Alcoholism 10/485 180/7482 0.738936284092603 0.999999998067058 0.903322133378977 2788/4852/54331/111/2770/4129/2354/4128/84699/8366 10 hsa00380 Tryptophan metabolism 2/485 40/7482 0.742341140268509 0.999999998067058 0.903322133378977 4129/4128 2 hsa04723 Retrograde endocannabinoid signaling 8/485 148/7482 0.752330976932093 0.999999998067058 0.903322133378977 2788/1268/11343/54331/111/3708/2770/2892 8 hsa03440 Homologous recombination 2/485 41/7482 0.754674745759057 0.999999998067058 0.903322133378977 8438/25788 2 hsa04975 Fat digestion and absorption 2/485 41/7482 0.754674745759057 0.999999998067058 0.903322133378977 80168/2168 2 hsa05219 Bladder cancer 2/485 41/7482 0.754674745759057 0.999999998067058 0.903322133378977 4312/9252 2 hsa00220 Arginine biosynthesis 1/485 21/7482 0.755695734077843 0.999999998067058 0.903322133378977 2875 1 hsa05226 Gastric cancer 8/485 149/7482 0.758923432719284 0.999999998067058 0.903322133378977 4233/2263/7472/7474/8322/4616/5243/11211 8 hsa04068 FoxO signaling pathway 7/485 132/7482 0.761132507953809 0.999999998067058 0.903322133378977 891/6446/9133/114907/4616/3479/10110 7 hsa04066 HIF-1 signaling pathway 5/485 100/7482 0.785513359920445 0.999999998067058 0.903322133378977 3570/7076/285/5336/3479 5 hsa03430 Mismatch repair 1/485 23/7482 0.786427236652326 0.999999998067058 0.903322133378977 9156 1 hsa04390 Hippo signaling pathway 8/485 154/7482 0.790016967633221 0.999999998067058 0.903322133378977 7004/332/7472/650/7474/653/8322/11211 8 hsa04152 AMPK signaling pathway 6/485 120/7482 0.799046385177573 0.999999998067058 0.903322133378977 23216/6319/890/84699/3952/3479 6 hsa04350 TGF-beta signaling pathway 4/485 85/7482 0.810424455828404 0.999999998067058 0.903322133378977 3624/650/653/1634 4 hsa04620 Toll-like receptor signaling pathway 5/485 104/7482 0.813286334096338 0.999999998067058 0.903322133378977 6373/2353/6696/7098/3553 5 hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/485 25/7482 0.813299926486229 0.999999998067058 0.903322133378977 80235 1 hsa00565 Ether lipid metabolism 2/485 47/7482 0.818432040060099 0.999999998067058 0.903322133378977 5050/79153 2 hsa00600 Sphingolipid metabolism 2/485 47/7482 0.818432040060099 0.999999998067058 0.903322133378977 6609/57704 2 hsa04340 Hedgehog signaling pathway 2/485 47/7482 0.818432040060099 0.999999998067058 0.903322133378977 2737/2619 2 hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/485 47/7482 0.818432040060099 0.999999998067058 0.903322133378977 477/6546 2 hsa00280 Valine, leucine and isoleucine degradation 2/485 48/7482 0.827489671096647 0.999999998067058 0.903322133378977 35/10449 2 hsa00520 Amino sugar and nucleotide sugar metabolism 2/485 48/7482 0.827489671096647 0.999999998067058 0.903322133378977 7360/7358 2 hsa04014 Ras signaling pathway 12/485 232/7482 0.830753559972745 0.999999998067058 0.903322133378977 2788/4233/5906/10235/54331/51196/2263/2260/285/5336/3479/3815 12 hsa00510 N-Glycan biosynthesis 2/485 49/7482 0.836139006468005 0.999999998067058 0.903322133378977 29880/25834 2 hsa01040 Biosynthesis of unsaturated fatty acids 1/485 27/7482 0.836797462222204 0.999999998067058 0.903322133378977 6319 1 hsa04966 Collecting duct acid secretion 1/485 27/7482 0.836797462222204 0.999999998067058 0.903322133378977 760 1 hsa04727 GABAergic synapse 4/485 89/7482 0.837775330066997 0.999999998067058 0.903322133378977 2788/54331/111/2770 4 hsa04979 Cholesterol metabolism 2/485 50/7482 0.844394789128428 0.999999998067058 0.903322133378977 255738/3990 2 hsa00650 Butanoate metabolism 1/485 28/7482 0.847414931145374 0.999999998067058 0.903322133378977 35 1 hsa04666 Fc gamma R-mediated phagocytosis 4/485 91/7482 0.850166272420903 0.999999998067058 0.903322133378977 2934/1073/85477/5336 4 hsa04520 Adherens junction 3/485 72/7482 0.854680672038743 0.999999998067058 0.903322133378977 4233/2260/10580 3 hsa04932 Non-alcoholic fatty liver disease (NAFLD) 7/485 149/7482 0.858140882991389 0.999999998067058 0.903322133378977 637/3570/840/3952/4512/3552/3553 7 hsa04621 NOD-like receptor signaling pathway 8/485 168/7482 0.861136957441419 0.999999998067058 0.903322133378977 2921/10628/2919/3708/118429/2920/3553/6347 8 hsa04912 GnRH signaling pathway 4/485 93/7482 0.861748073488051 0.999999998067058 0.903322133378977 2767/111/3708/1958 4 hsa00030 Pentose phosphate pathway 1/485 30/7482 0.866626319805526 0.999999998067058 0.903322133378977 9104 1 hsa00062 Fatty acid elongation 1/485 30/7482 0.866626319805526 0.999999998067058 0.903322133378977 10449 1 hsa05320 Autoimmune thyroid disease 2/485 53/7482 0.866945159130848 0.999999998067058 0.903322133378977 3002/7173 2 hsa05100 Bacterial invasion of epithelial cells 3/485 74/7482 0.86720680321964 0.999999998067058 0.903322133378977 4233/3611/857 3 hsa04145 Phagosome 7/485 152/7482 0.871405956504128 0.999999998067058 0.903322133378977 84617/3673/79861/718/4973/81035/7060 7 hsa05214 Glioma 3/485 75/7482 0.873106206701028 0.999999998067058 0.903322133378977 4616/5336/3479 3 hsa00410 beta-Alanine metabolism 1/485 31/7482 0.875306705593814 0.999999998067058 0.903322133378977 8639 1 hsa03020 RNA polymerase 1/485 31/7482 0.875306705593814 0.999999998067058 0.903322133378977 51082 1 hsa04150 mTOR signaling pathway 7/485 153/7482 0.875594440099318 0.999999998067058 0.903322133378977 6446/7472/7474/8322/220441/3479/11211 7 hsa05160 Hepatitis C 7/485 155/7482 0.883633289782325 0.999999998067058 0.903322133378977 9076/637/137075/23562/9075/7098/9073 7 hsa05150 Staphylococcus aureus infection 2/485 56/7482 0.886462116398205 0.999999998067058 0.903322133378977 1675/718 2 hsa00240 Pyrimidine metabolism 2/485 57/7482 0.892355722775941 0.999999998067058 0.903322133378977 6241/957 2 hsa03018 RNA degradation 3/485 79/7482 0.894447319786639 0.999999998067058 0.903322133378977 87178/3329/7832 3 hsa05213 Endometrial cancer 2/485 58/7482 0.897964343944849 0.999999998067058 0.903322133378977 3611/4616 2 hsa05152 Tuberculosis 8/485 179/7482 0.902207199003331 0.999999998067058 0.903322133378977 637/3329/51561/4046/3587/718/3552/3553 8 hsa04370 VEGF signaling pathway 2/485 59/7482 0.903300067565105 0.999999998067058 0.903322133378977 3315/5336 2 hsa05012 Parkinson disease 6/485 142/7482 0.905985604856543 0.999999998067058 0.903322133378977 65018/291/7345/111/2770/4512 6 hsa04142 Lysosome 5/485 123/7482 0.90822096872521 0.999999998067058 0.903322133378977 6609/2517/1511/8722/8905 5 hsa04217 Necroptosis 7/485 162/7482 0.908430199993435 0.999999998067058 0.903322133378977 637/6609/291/5837/7098/3552/3553 7 hsa04922 Glucagon signaling pathway 4/485 103/7482 0.908808048592713 0.999999998067058 0.903322133378977 3708/5837/2641/84699 4 hsa04146 Peroxisome 3/485 83/7482 0.912513064250733 0.999999998067058 0.903322133378977 1610/2053/55670 3 hsa04742 Taste transduction 3/485 83/7482 0.912513064250733 0.999999998067058 0.903322133378977 6338/6335/5028 3 hsa05161 Hepatitis B 6/485 144/7482 0.912683679076581 0.999999998067058 0.903322133378977 332/4772/890/2353/84699/7098 6 hsa03008 Ribosome biogenesis in eukaryotes 4/485 105/7482 0.916306780960693 0.999999998067058 0.903322133378977 26354/23160/10799/1736 4 hsa05216 Thyroid cancer 1/485 37/7482 0.916747815834452 0.999999998067058 0.903322133378977 4616 1 hsa04623 Cytosolic DNA-sensing pathway 2/485 63/7482 0.922142875922368 0.999999998067058 0.903322133378977 51082/3553 2 hsa05330 Allograft rejection 1/485 38/7482 0.922171228772033 0.999999998067058 0.903322133378977 3002 1 hsa04931 Insulin resistance 4/485 107/7482 0.923250699844609 0.999999998067058 0.903322133378977 133522/5837/5507/84699 4 hsa00620 Pyruvate metabolism 1/485 39/7482 0.92724201787004 0.999999998067058 0.903322133378977 197257 1 hsa04137 Mitophagy - animal 2/485 65/7482 0.930214095009832 0.999999998067058 0.903322133378977 65018/10370 2 hsa05033 Nicotine addiction 1/485 40/7482 0.931983066013669 0.999999998067058 0.903322133378977 2892 1 hsa04650 Natural killer cell mediated cytotoxicity 5/485 131/7482 0.933450420785089 0.999999998067058 0.903322133378977 637/4772/3002/1437/5336 5 hsa05223 Non-small cell lung cancer 2/485 66/7482 0.933947053817557 0.999999998067058 0.903322133378977 4616/5336 2 hsa04211 Longevity regulating pathway 3/485 89/7482 0.934388519470607 0.999999998067058 0.903322133378977 111/84699/3479 3 hsa05162 Measles 5/485 132/7482 0.936124623680608 0.999999998067058 0.903322133378977 3306/51209/3303/3552/3553 5 hsa04720 Long-term potentiation 2/485 67/7482 0.93749057681424 0.999999998067058 0.903322133378977 5906/3708 2 hsa00010 Glycolysis / Gluconeogenesis 2/485 68/7482 0.940853473470632 0.999999998067058 0.903322133378977 126/124 2 hsa04664 Fc epsilon RI signaling pathway 2/485 68/7482 0.940853473470632 0.999999998067058 0.903322133378977 1437/5336 2 hsa05145 Toxoplasmosis 4/485 113/7482 0.941085146568556 0.999999998067058 0.903322133378977 2770/3306/3587/3303 4 hsa04920 Adipocytokine signaling pathway 2/485 69/7482 0.94404421003061 0.999999998067058 0.903322133378977 4852/3952 2 hsa05211 Renal cell carcinoma 2/485 69/7482 0.94404421003061 0.999999998067058 0.903322133378977 4233/5906 2 hsa05222 Small cell lung cancer 3/485 93/7482 0.94604520818115 0.999999998067058 0.903322133378977 1164/3673/4616 3 hsa04962 Vasopressin-regulated water reabsorption 1/485 44/7482 0.948057603373353 0.999999998067058 0.903322133378977 84699 1 hsa01200 Carbon metabolism 4/485 116/7482 0.948509262062575 0.999999998067058 0.903322133378977 35/2875/29968/9104 4 hsa05165 Human papillomavirus infection 15/485 330/7482 0.94854143153668 0.999999998067058 0.903322133378977 7472/3679/3696/890/9368/7474/84699/3673/8322/6696/1291/1292/7098/7060/11211 15 hsa05203 Viral carcinogenesis 8/485 201/7482 0.954332380477044 0.999999998067058 0.903322133378977 2934/1111/5366/890/84699/85477/718/8366 8 hsa01522 Endocrine resistance 3/485 98/7482 0.957913056342971 0.999999998067058 0.903322133378977 111/2353/3479 3 hsa01230 Biosynthesis of amino acids 2/485 75/7482 0.960006081432192 0.999999998067058 0.903322133378977 2875/29968 2 hsa05168 Herpes simplex infection 7/485 185/7482 0.960698632359289 0.999999998067058 0.903322133378977 5187/8863/2353/718/7098/3553/6347 7 hsa05220 Chronic myeloid leukemia 2/485 76/7482 0.962201574857471 0.999999998067058 0.903322133378977 861/4616 2 hsa04660 T cell receptor signaling pathway 3/485 101/7482 0.963811482736121 0.999999998067058 0.903322133378977 4772/1437/2353 3 hsa04612 Antigen processing and presentation 2/485 77/7482 0.96428124804988 0.999999998067058 0.903322133378977 3306/3303 2 hsa04072 Phospholipase D signaling pathway 5/485 146/7482 0.964664147329373 0.999999998067058 0.903322133378977 1902/111/5336/2918/3815 5 hsa04714 Thermogenesis 9/485 229/7482 0.966054409600871 0.999999998067058 0.903322133378977 1268/11343/8110/111/2260/6604/2641/84699/4512 9 hsa05010 Alzheimer disease 6/485 171/7482 0.969888409058617 0.999999998067058 0.903322133378977 637/6263/3708/840/4512/3553 6 hsa05164 Influenza A 6/485 171/7482 0.969888409058617 0.999999998067058 0.903322133378977 3306/3303/7098/3552/3553/6347 6 hsa03460 Fanconi anemia pathway 1/485 54/7482 0.973545527985942 0.999999998067058 0.903322133378977 29089 1 hsa05322 Systemic lupus erythematosus 4/485 133/7482 0.976654594692053 0.999999998067058 0.903322133378977 1511/730/718/8366 4 hsa05206 MicroRNAs in cancer 12/485 299/7482 0.976927867975809 0.999999998067058 0.903322133378977 113130/4233/995/27250/9252/2146/6659/5328/5268/8091/5243/5336 12 hsa04012 ErbB signaling pathway 2/485 85/7482 0.9773874568148 0.999999998067058 0.903322133378977 5336/2069 2 hsa04910 Insulin signaling pathway 4/485 137/7482 0.980739119893584 0.999999998067058 0.903322133378977 5837/5507/10580/5577 4 hsa00310 Lysine degradation 1/485 59/7482 0.981127275941786 0.999999998067058 0.903322133378977 2146 1 hsa04141 Protein processing in endoplasmic reticulum 5/485 165/7482 0.984908826897392 0.999999998067058 0.903322133378977 1410/3306/3303/10808/9532 5 hsa04658 Th1 and Th2 cell differentiation 2/485 92/7482 0.984931223630641 0.999999998067058 0.903322133378977 4772/2353 2 hsa04071 Sphingolipid signaling pathway 3/485 118/7482 0.984989751967411 0.999999998067058 0.903322133378977 637/6609/2770 3 hsa04722 Neurotrophin signaling pathway 3/485 119/7482 0.985763593585227 0.999999998067058 0.903322133378977 5906/9252/5336 3 hsa05231 Choline metabolism in cancer 2/485 99/7482 0.990006375153565 0.999999998067058 0.903322133378977 6584/2353 2 hsa04917 Prolactin signaling pathway 1/485 70/7482 0.991029583448777 0.999999998067058 0.903322133378977 2353 1 hsa03010 Ribosome 4/485 153/7482 0.991256487790102 0.999999998067058 0.903322133378977 63875/51373/6227/200916 4 hsa05169 Epstein-Barr virus infection 6/485 201/7482 0.991835827326101 0.999999998067058 0.903322133378977 637/890/1380/4616/930/5336 6 hsa05212 Pancreatic cancer 1/485 75/7482 0.993605295897156 0.999999998067058 0.903322133378977 4616 1 hsa04721 Synaptic vesicle cycle 1/485 78/7482 0.994781137233471 0.999999998067058 0.903322133378977 6616 1 hsa03013 RNA transport 4/485 165/7482 0.995256307189717 0.999999998067058 0.903322133378977 79023/79833/10799/129401 4 hsa05016 Huntington disease 5/485 193/7482 0.996029595362195 0.999999998067058 0.903322133378977 291/3708/146754/84699/4512 5 hsa04140 Autophagy - animal 2/485 128/7482 0.998250397840618 0.999999998067058 0.903322133378977 58476/3708 2 hsa00564 Glycerophospholipid metabolism 1/485 97/7482 0.99856175438084 0.999999998067058 0.903322133378977 55500 1 hsa00190 Oxidative phosphorylation 2/485 133/7482 0.998711617945644 0.999999998067058 0.903322133378977 5464/4512 2 hsa03040 Spliceosome 2/485 134/7482 0.998788308073896 0.999999998067058 0.903322133378977 3306/3303 2 hsa04144 Endocytosis 5/485 244/7482 0.999711448115906 0.999999998067058 0.903322133378977 2263/3306/857/3303/3800 5 hsa04120 Ubiquitin mediated proteolysis 1/485 137/7482 0.999905693731798 0.999999998067058 0.903322133378977 11065 1 hsa04740 Olfactory transduction 5/485 448/7482 0.999999998067058 0.999999998067058 0.903322133378977 2788/5138/1261/6546/5997 5