,,,,,,,,,,,,,,,
"Supplementary TableS4. The EV characterizing proteins which was detected by shotgun analysis.  The list of the detected proteins which characterize EVs in MISEV2018. According to MISEV2018, ",,,,,,,,,,,,,,,
"we show proteins in line with Category 1, 2 and 4. XX = human gene names. XX* used for families of multiple proteins, for example for integrins: ITGA* indicates any integrin alpha chain. ",,,,,,,,,,,,,,,
P: The UniProt Accession number of the protein detected in plasma extraction compartment (Score) .  U: The UniProt Accession number of the protein detected in urine extraction compartment (Score) . ,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
"1- Transmembrane or GPI-anchored proteins 
associated to plasma membrane ",,,,,,,,2- Cytosolic proteins recovered in EVs,,,,,,,
and/or endosomes,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
All EVs,,,,,,,,All EVs,,,,,,,
,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
1a: non-tissue specific.,,,,1b: cell/tissue specific.,,,,2a: with lipid or membrane protein,,,,2b: promiscuous incorporation in EVs ,,,
,,,,,,,,-binding ability.,,,,(and possibly exomeres),,,
Tetraspanins,,,,Some TSPANs,,,,ESCRT-I/II/III,,,,Heat shock protein HSP70,,,
CD63,,U: P08962 (8) ,,CD9,,"P: P21926 (3)
U: P21926 (7) ",,TSG101,,U: Q99816 (23),,HSPA1A,,U: P0DMV8 (109),
multi-pass membrane proteins,,,,"(absent from NK,B some MSC)",,,,CHMP*,CHMP1A,U: Q9HD42 (9),,cytoskeleton,,,
CD47,,U: Q08722 (5) ,,PECAM1,,,,,CHMP1B,U: Q7LBR1 (6),,actin,,,
GNA*,GNAI1,U: P63096 (65) ,,"PECAM1
(endothelial)",,P: P16284 (22),,,CHMP2A,U: O43633 (33),,ACT*,ACTB,"P: P60709(927)
U: P60709 (1618)",
,GNAI2,"P: P04899 (16)
U: P04899 (75) ",,CD90,,,,,CHMP2B,U: Q9UQN3 (9),,,ACTBL2,"P: Q562R1(252)
U: Q562R1 (169)",
,GNAI3,U: P08754 (58) ,,"THY1
(MSCs)",,U: P04216 (7),,,CHMP4A,U: Q9BY43 (6),,,ACTG2,"P: P63267(500)
U: P63267 (476)",
,GNAZ,U: P19086 (15),,CD45,,,,,CHMP4B,U: Q9H444 (26),,tublin,,,
,GNAQ,"P: P50148 (3)
U: P50148 (38)",,"PTPRC
(immune cells)",,P: P08575 (29),,,CHMP4C,U: Q96CF2(21),,TUB*,TUBA1B,"P: P68363 (42)
U: P68363 (106)",
,GNA11,U: P29992 (24) ,,CD41,,,,,CHMP5,U: Q9NZZ3(64),,,TUBA4A,"P: P68366 (35)
U: P68366 (88)",
,GNAS,U: Q5JWF2 (50),,"ITGA2B
(platelets)",,P: P08514 (129),,,CHMP6,U: Q96FZ7(9),,,TUBB,"P: P07437 (53)
U: P07437 (111)",
MHC class I,,,,CD42a,,,,accessory proteins,,,,,TUBB1,P: Q9H4B7 (48),
HLA-A,,P: P01891 (8),,"GP9
(platelets)",,P: P14770 (14),,ALIX (PDCD6IP),,U: Q8WUM4 (158),,,TUBB2A,U: Q13885 (77),
HLA-B,,P: Q31612 (11),,Glycophorin A,,,,VPS4A,,U: Q9UN37 (24),,,TUBB4A,U: P04350 (107),
Integrins,,,,GYPA(RBC),,P: P02724(4),,VPS4B,,U: O75351 (29),,,TUBB4B,"P: P68371 (44)
U: P68371 (114)",
ITGA*,ITGA2B,P: P08514 (129),,CD14,,,,ARRDC1,,,,enzymes,,,
,ITGAX,P: P20702 (11),,CD14(Monocyte),,"P: P08571 (4)
U: P08571 (7)",,ARRDC1,,U: Q8N5I2 (9),,GAPDH,,"P: P04406 (12)
U: P04406 (188)",
,ITGA6,P: P23229 (6) ,,MHC�@class ‡U,,,,Flotillins-1 and 2,,,,,,,
,ITGAV,U: P06756 (15),,"�iDC, B cell ,endotherial, phagocyte)",,,,flotillin1,,"P: O75955 (13)
U: O75955 (42)",,,,,
ITGB*,ITGB1,"P: P05556 (7)
U: P05556 (4)",,HLA-DRA,,U: P01903 (12),,flotillin2,,"P: Q14254 (3)
U: Q14254 (25)",,,,,
,ITGB2,P: P05107 (4),,HLA-DRB1,,"P: P01911 (7)
U: P01911 (10)",,EHD*,,,,,,,
,ITGB3,P: P05106 (57) ,,,,,,EHD*,EHD1,"P: Q9H4M9 (2)
U: Q9H4M9 (107)",,,,,
LAMP1/2,,,,,,,,,EHD3,U: Q9NZN3 (2),,,,,
LAMP 1,,"P: P11279 (2)
U: P11279 (3)",,,,,,,EHD4,U: Q9H223 (66),,,,,
LAMP 2,,U: P13473 (3),,,,,,RHOA,,,,,,,
EMMPRIN,,,,,,,,RHOA,,"P: P61586 (8)
U: P61586 (86)",,,,,
BSG,,"P: P35613 (2)
U: P35613 (8)",,,,,,annexins,,,,,,,
GPI-anchored 5'nucleotidase,,,,,,,,ANXA*,ANXA1,U: P04083 (24),,,,,
CD73,,U: P21589 (3),,,,,,,ANXA2,U: P07355 (127),,,,,
complement-binding proteins,,,,,,,,,ANXA3,"P: P12429 (5)
U: P12429 (55)",,,,,
CD55,,U: P08174 (5),,,,,,,ANXA4,U: P09525 (162),,,,,
CD59,,"P: P13987 (7)
U: P13987 (34)",,,,,,,ANXA5,"P: P08758 (6)
U: P08758 (116)",,,,,
,,,,,,,,,ANXA6,"P: P08133 (12)
U: P08133 (103)",,,,,
,,,,,,,,,ANXA7,U: P20073 (54),,,,,
,,,,,,,,,ANXA11,U: P50995 (147),,,,,
,,,,,,,,,ANXA13,U: P27216 (16),,,,,
,,,,,,,,Heat shock proteins,,,,,,,
,,,,,,,,HSC70 (HSPA8),,"P: P11142 (18)
U: P11142 (122)",,,,,
,,,,,,,,HSP84 (HSP90AB1),,U: P08238 (59),,,,,
,,,,,,,,ARF6,,,,,,,
,,,,,,,,ARF6,,U: P62330 (8),,,,,
,,,,,,,,syntenin,,,,,,,
,,,,,,,,SDCBP,,U: O00560 (46),,,,,
,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
"4- Transmembrane, lipidbound and soluble proteins 
associated to other intracellular compartments
than PM/endosomes
",,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
"Subtypes of EVs(e.g.large oncosomes ,largeEVs)and/ or pathologic/atypicalstate",,,,,,,,,,,,,,,
,,,,,,,,,,,,,,,
4a: nucleus.,,,,,,,,,,,,,,,
Histones,,,,,,,,,,,,,,,
HIST1H*,HIST1H2BA,P: Q96A08 (2),,,,,,,,,,,,,
,,,,,,,,,,,,,,,
"4c: secretory pathway
(endoplasmic reticulum,
Golgi apparatus)
",,,,,,,,,,,,,,,
GRP94,,,,,,,,,,,,,,,
HSP90B1,,P: P14625 (3),,,,,,,,,,,,,
BIP,,,,,,,,,,,,,,,
HSPA5,,P: P11021 (6),,,,,,,,,,,,,
,,,,,,,,,,,,,,,
"4d: others (autophagosomes,
cytoskeleton�c)",,,,,,,,,,,,,,,
Actinin1/4,,,,,,,,,,,,,,,
ACTN1,,"P: P12814 (46)
U: P12814 (60)",,,,,,,,,,,,,
ACTN4,,"P: O43707 (14)
U: O43707 (147)",,,,,,,,,,,,,
,,,,,,,,,,,,,,,