Table S4:KEGG enrichment results of differentially expressed genes in LCC and RCC Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa00140:Steroid hormone biosynthesis 7 1.983002833 7.05E-04 UGT2B10, UGT1A1, HSD3B2, HSD17B2, CYP1A1, UGT2B4, UGT2A3 130 58 6879 6.386339523 0.121065661 0.128999595 0.1247701 KEGG_PATHWAY hsa00910:Nitrogen metabolism 4 1.133144476 0.003614428 CA5A, CA4, CA9, CA8 130 17 6879 12.45067873 0.484510663 0.307892383 0.297797551 KEGG_PATHWAY hsa00590:Arachidonic acid metabolism 6 1.699716714 0.005513848 PLA2G2D, PLA2G12B, CYP4F2, PLA2G3, PLA2G4A, CYP4F8 130 61 6879 5.204791929 0.636445563 0.307892383 0.297797551 KEGG_PATHWAY hsa00830:Retinol metabolism 6 1.699716714 0.006759028 UGT2B10, SDR16C5, UGT1A1, CYP1A1, UGT2B4, UGT2A3 130 64 6879 4.960817308 0.710934267 0.307892383 0.297797551 KEGG_PATHWAY hsa00983:Drug metabolism - other enzymes 5 1.416430595 0.010485013 UGT2B10, UGT1A1, UGT2B4, UGT2A3, CES1 130 46 6879 5.751672241 0.85469022 0.307892383 0.297797551 KEGG_PATHWAY hsa00592:alpha-Linolenic acid metabolism 4 1.133144476 0.010962024 PLA2G2D, PLA2G12B, PLA2G3, PLA2G4A 130 25 6879 8.466461538 0.866962808 0.307892383 0.297797551 KEGG_PATHWAY hsa04950:Maturity onset diabetes of the young 4 1.133144476 0.012224726 PKLR, RFX6, PAX4, NEUROG3 130 26 6879 8.140828402 0.894696802 0.307892383 0.297797551 KEGG_PATHWAY hsa00053:Ascorbate and aldarate metabolism 4 1.133144476 0.013567503 UGT2B10, UGT1A1, UGT2B4, UGT2A3 130 27 6879 7.839316239 0.917902689 0.307892383 0.297797551 KEGG_PATHWAY hsa00591:Linoleic acid metabolism 4 1.133144476 0.016495874 PLA2G2D, PLA2G12B, PLA2G3, PLA2G4A 130 29 6879 7.29867374 0.952352282 0.307892383 0.297797551 KEGG_PATHWAY hsa05204:Chemical carcinogenesis 6 1.699716714 0.01682472 UGT2B10, UGT1A1, CHRNA7, CYP1A1, UGT2B4, UGT2A3 130 80 6879 3.968653846 0.955180819 0.307892383 0.297797551 KEGG_PATHWAY hsa04724:Glutamatergic synapse 7 1.983002833 0.019882534 GNG4, PLA2G4A, GRIK2, SLC17A8, SLC38A3, SLC1A7, KCNJ3 130 114 6879 3.249190283 0.974654694 0.330773061 0.319928043 KEGG_PATHWAY hsa00040:Pentose and glucuronate interconversions 4 1.133144476 0.023335223 UGT2B10, UGT1A1, UGT2B4, UGT2A3 130 33 6879 6.413986014 0.986712872 0.355862156 0.344194545 KEGG_PATHWAY hsa04650:Natural killer cell mediated cytotoxicity 7 1.983002833 0.026728645 NCR1, KLRK1, IFNG, FASLG, ULBP2, KIR2DL3, KIR2DL4 130 122 6879 3.036128625 0.992972331 0.376257079 0.363920781 KEGG_PATHWAY hsa04975:Fat digestion and absorption 4 1.133144476 0.036057734 ABCG8, PLA2G2D, PLA2G12B, PLA2G3 130 39 6879 5.427218935 0.998794028 0.471326097 0.455872782 KEGG_PATHWAY hsa00860:Porphyrin and chlorophyll metabolism 4 1.133144476 0.043510953 UGT2B10, UGT1A1, UGT2B4, UGT2A3 130 42 6879 5.03956044 0.999708633 0.530833623 0.513429242 KEGG_PATHWAY hsa00980:Metabolism of xenobiotics by cytochrome P450 5 1.416430595 0.049685909 UGT2B10, UGT1A1, CYP1A1, UGT2B4, UGT2A3 130 74 6879 3.575363825 0.999910938 0.547635252 0.529679997 KEGG_PATHWAY hsa00565:Ether lipid metabolism 4 1.133144476 0.05167106 PLA2G2D, PLA2G12B, PLA2G3, PLA2G4A 130 45 6879 4.703589744 0.999939257 0.547635252 0.529679997 KEGG_PATHWAY hsa04612:Antigen processing and presentation 5 1.416430595 0.053865762 CIITA, IFNG, KIR3DL2, KIR2DL3, KIR2DL4 130 76 6879 3.481275304 0.999960248 0.547635252 0.529679997 KEGG_PATHWAY hsa04913:Ovarian steroidogenesis 4 1.133144476 0.063612246 HSD3B2, HSD17B2, CYP1A1, PLA2G4A 130 49 6879 4.319623234 0.999994024 0.612686368 0.59259829 KEGG_PATHWAY hsa04080:Neuroactive ligand-receptor interaction 10 2.83286119 0.075410663 GABRP, CHRM1, CHRNA7, GZMA, NMUR2, PRL, GRIK2, DRD2, GRPR, DRD5 130 277 6879 1.910302694 0.999999413 0.690007565 0.667384366