Variant Identifier,Gene,Reference (PubMed Identifier),Manual Classification (Type A/B),PharmGKB Evidence Category,PharmGKB Annotation,ADME,GO Annotation 'xenobiotic metabolic process',Retained by filtering strategy,True Positive (TP) Count,False Positive (FP) Count,True Negative (TN) Count,False Negative (FN) Count
rs1057910,CYP2C9,32423989,A,1A,Dosage,,,N,,,1,
rs111888148,RYR1,27646467,B,1A,Toxicity/ADR,Y,,N,,,2,
rs115545701,CFTR,23891399,A,1A,Efficacy,,,N,,,3,
rs115232898,DPYD,23588312,A,1A,Toxicity/ADR,,,Y,,1,,
rs12248560,CYP2C19,24257813,A,1A,"Dosage,Efficacy,Toxicity/ADR",,,N,,,4,
rs1800559,CACNA1S,9199552,B,1A,Toxicity/ADR,Y,,N,,,5,
rs1050828,G6PD,22190578,B,1B,Toxicity/ADR,,,Y,1, ,,
rs121434568,EGFR,26490356,A,1B,Efficacy,,,N,,,6,
rs2228001,XPC,19434073,A,1B,Toxicity/ADR,,,Y,,2,,
rs3745274,CYP2B6,25611810,A,1B,Dosage,,,N,,,7,
rs1041983,NAT2,18544910,A,2A,Toxicity/ADR,,Y,N,,,8,
rs1045642,ABCB1,25007187,A,2A,Other,,,N,,,9,
rs1695,GSTP1,23065688,B,2A,Toxicity/ADR,,Y,N,,,10,
rs1801133,MTHFR,11710708,A,2A,"Dosage,Efficacy,Toxicity/ADR",,,N,,,11,
rs2032582,ABCB1,20707787,A,2A,Efficacy,,,N,,,12,
rs2279345,CYP2B6,22471906,A,2A,Metabolism/PK,,,N,,,13,
rs2359612,VKORC1,20203262,A,2A,Dosage,,,N,,,14,
rs10306114,PTGS1,22940005,A,2B,Efficacy,,,N,,,15,
rs1051740,EPHX1,15692831,A,2B,Dosage,,,N,,,16,
rs1076560,DRD2,23340505,A,2B,Toxicity/ADR,,,Y,,3,,
rs11598702,NT5C2,22838949,A,2B,Other,,,N,,,17,
rs1414334,HTR2C,17632216,B,2B,Toxicity/ADR,,,Y,2,,,
rs1799971,OPRM1,19683391,A,2B,Efficacy,,,N,,,18,
rs1872328,ACYP2,25665007,B,2B,Toxicity/ADR,,,Y,3,,,
rs20455,KIF6,20886236,B,2B,Efficacy,,,N, ,, ,1
rs264588,TANC1,24974847,B,2B,Toxicity/ADR,,,Y,4,,,
rs3753380,PTGFR,17467803,A,2B,Efficacy,,,N,,,19,
rs71647871,CES1,23111421,A,2B,Efficacy,,,N,,,20,
rs7997012,HTR2A,19590397,A,2B,Efficacy,,,N,,,21,
rs7270101,ITPA,18616518,B,2B,Toxicity/ADR,,,Y,5,,,
,,,,,,,,,,,,
,,,,,,,,,,,,
Supplemental Table 1 –  Thirty PharmGKB variants with a known pharmacogenetic mechanism used for scoring classification scheme.,,,,,,,,,,,,