Variantgroup,PharmGKB evidence level,rs_ID, SIFT Score,PolyPhen Score,CADD Phred Score,DANN Sacore,FATHMM Score,GERP++ NR,MutPred Score,MutationAssessor Score,MutationTaster Score,REVEL Score,PhastCons 20way mammalian
pgkb,1A,rs116855232,0.11,0.043,22.2,0.936,2.46,5.39,NA,2.02,0.00463,0.17,0.508
pgkb,1A,rs121908755,0,0.999,29.7,0.997,-5.18,5.06,NA,4.735,1,0.908,1
pgkb,1A,rs115545701,0.19,0.677,24,0.999,-3.45,5.68,NA,0.95,0.86939,0.476,1
pgkb,1A,rs121908752,0,0.999,24.8,0.96,-2.88,5.52,NA,2.785,0.99998,0.903,0.902
pgkb,1A,rs397508537,0.04,0.903,16.39,0.996,-6.82,5.73,0.834,0.81,1,0.733,0.896
pgkb,1A,rs121918594,0,0.994,26.2,0.999,-4.61,3.99,0.881,2.585,0.99988,0.959,0.995
pgkb,1A,rs150212784,0,0.945,25.6,0.999,-2.57,5.69,0.783,2.23,1,0.95,1
pgkb,1A,rs11971167,0,1,34,0.999,-2.85,5.2,NA,1.695,1,0.817,0.926
pgkb,1A,rs193922843,0,1,24.8,0.962,-0.18,4.31,0.924,2.83,1,0.75,0.99
pgkb,1A,rs80282562,0,0.997,34,0.999,-4.53,5.5,0.975,3.03,1,0.966,1
pgkb,1A,rs397508288,0,1,28.6,0.996,-3.87,4.83,0.986,3.88,1,0.991,1
pgkb,1A,rs368505753,0,0.999,33,0.999,-3.08,5.68,NA,3.95,1,0.926,0.992
pgkb,1A,rs193922747,0,0.999,26.9,0.99,-4.95,4.87,0.953,2.93,1,0.947,0.994
pgkb,1A,rs121918592,0.01,0.914,32,0.998,-2.05,4.7,0.866,2.215,0.99943,0.864,0.996
pgkb,1A,rs78769542,0.09,0.998,26.8,1,-2.67,5.69,NA,0.99,1,0.696,0.979
pgkb,1A,rs193922832,0.11,0.992,23.9,0.998,-4.15,4.36,0.756,1.93,0.99999,0.868,0.998
pgkb,1A,rs118192161,0,0.998,32,0.998,-4.87,4.26,0.858,2.98,0.99991,0.959,0.949
pgkb,1A,rs121908753,0.01,0.995,26.7,1,-2.88,5.26,0.887,1.95,1,0.804,0.998
pgkb,1A,rs63749869,0,0.996,28.4,0.986,-2.97,4.71,0.87,3.15,1,0.912,1
pgkb,1A,rs118192175,0,0.997,34,0.999,-3.82,4.63,0.964,2.81,1,0.956,0.996
pgkb,1A,rs118192162,0,0.999,27.2,0.955,-3.12,4.12,0.948,2.89,0.99997,0.942,1
pgkb,1A,rs118192172,0,0.994,35,0.999,-3.86,3.76,NA,2.83,1,0.927,0.979
pgkb,1A,rs193922762,0,0.999,28.8,0.996,-2.25,4.61,0.87,2.545,0.87777,0.76,0.989
pgkb,1A,rs1801268,0,0.999,34,0.995,-3.03,5.46,0.766,2.18,1,0.947,0.993
pgkb,1A,rs193922803,0.01,0.958,34,0.999,-3.88,3.99,0.951,2.645,0.977,0.861,1
pgkb,1A,rs193922816,0,0.996,26.7,0.999,-4.65,3.99,0.952,2.635,0.99997,0.913,0.996
pgkb,1A,rs75541969,0,0.572,31,0.996,-3.51,5.9,NA,2.785,0.99997,0.657,0.991
pgkb,1A,rs111888148,0,0.998,33,0.998,-3.94,4.01,NA,2.785,0.99499,0.93,1
pgkb,1A,rs55886062,0,0.988,31,0.996,-0.89,5.2,NA,2.21,1,0.92,1
pgkb,1A,rs121909020,0,1,33,0.999,-2.92,5.69,NA,3.575,1,0.922,0.995
pgkb,1A,rs202179988,0,1,35,0.999,-2.6,5.69,NA,1.55,1,0.799,0.978
pgkb,1A,rs121918595,0,0.996,25.9,0.972,-5.07,4.57,0.893,2.99,1,0.977,0.999
pgkb,1A,rs78655421,0.01,1,24.9,0.999,-6.83,5.73,NA,2.075,1,0.807,0.583
pgkb,1A,rs193922768,0,0.998,33,0.992,-4.23,4.01,0.879,2.765,0.99548,0.86,0.997
pgkb,1A,rs193922809,0.27,0.994,21.2,0.992,-4.76,3.99,NA,0.91,0.99996,0.85,0.989
pgkb,1A,rs193922753,0,0.996,30,0.985,-4.94,4.26,0.716,2.98,0.99864,0.864,0.915
pgkb,1A,rs4149056,0,0.996,22.9,0.983,0.95,3.62,NA,3.31,0.99999,0.221,0.046
pgkb,1A,rs397508513,0.21,0.882,21.1,0.998,-2.47,5.69,0.84,0.72,1,0.786,1
pgkb,1A,rs74503330,0,0.965,29.2,0.997,-4.58,5.2,0.973,4.735,1,0.91,0.997
pgkb,1A,rs118192163,0,0.996,30,0.998,-3.8,4.63,0.948,2.81,1,0.933,0.994
pgkb,1A,rs193922525,0,1,32,0.998,-5.8,5.63,0.98,4.045,1,0.994,1
pgkb,1A,rs121909005,0,1,27.6,0.998,-5.18,5.06,NA,5.085,1,0.937,1
pgkb,1A,rs144336148,0.35,0.998,25.7,0.999,-4.19,4.01,NA,1.615,0.99826,0.824,0.995
pgkb,1A,rs67376798,0,0.929,29.9,0.995,-3.15,5.82,NA,2.12,1,0.962,0.883
pgkb,1A,rs118192122,0,0.994,26.3,0.999,-4.62,3.99,0.928,2.635,0.99952,0.923,0.992
pgkb,1A,rs1057910,0.02,0.045,20.4,0.957,-0.35,3.78,NA,1.81,0.96671,0.07,0.982
pgkb,1A,rs118192170,0,0.99,24,0.954,-2.97,5.08,0.906,3.415,1,0.953,0.997
pgkb,1A,rs74551128,0,0.987,33,0.994,-3.33,4.85,NA,3.565,1,0.901,0.794
pgkb,1A,rs75527207,0,1,33,0.999,-5.8,5.27,NA,4.255,1,0.99,0.993
pgkb,1A,rs1799853,0.05,0.986,29.1,0.998,-0.44,3.54,NA,2.225,0.00177,0.34,0.002
pgkb,1A,rs118192168,0.08,0.987,25.8,0.977,-4.94,4.57,0.83,0.835,0.99999,0.817,0.997
pgkb,1A,rs118192167,0,0.998,24,0.977,-4.54,4.84,0.907,3.465,1,0.977,1
pgkb,1A,rs397508759,0.01,0.949,26.2,0.999,-2.63,5.5,0.857,1.9,1,0.823,1
pgkb,1A,rs115232898,0.01,0.905,25.7,0.998,-1.53,5.5,NA,0.97,1,0.581,1
pgkb,1A,rs1800559,0,0.998,27.6,0.998,-4.04,5.17,0.832,3.64,1,0.937,0.948
pgkb,1A,rs121908757,0,1,29.5,0.998,-5.18,5.06,0.97,5.085,1,0.988,1
pgkb,1A,rs113993958,0.02,0.988,22.6,0.996,-6.89,5.73,0.888,2.095,1,0.932,0.979
pgkb,1A,rs772226819,0,0.996,34,0.999,-4.99,4.48,NA,5.21,0.99992,0.91,0.998
pgkb,1A,rs112563513,0,0.994,24.9,0.998,-3.81,3.69,0.911,2.62,0.999,0.903,0.99
pgkb,1A,rs193922876,0,0.986,25.6,0.966,-4.89,4.57,0.858,3.06,1,0.975,0.99
pgkb,1A,rs186045772,0,0.999,24.6,0.999,-2.72,5.69,NA,2.065,1,0.804,1
pgkb,1A,rs121909013,0.02,0.998,33,0.999,-5.77,5.27,0.989,3.675,1,0.99,0.997
pgkb,1A,rs77834169,0.01,1,27.8,0.997,-6.81,5.73,0.694,1.38,1,0.737,0.581
pgkb,1A,rs193922818,0,0.994,25.1,0.998,-2.91,4.17,0.946,2.65,0.99958,0.898,0.993
pgkb,1A,rs118192116,0.02,0.952,22.8,0.593,-4.38,4.18,0.808,2.955,0.01039,0.618,0.809
pgkb,1A,rs121918593,0,1,23.8,0.996,-6.36,3.99,NA,2.595,0.99999,0.965,0.992
pgkb,1A,rs1801086,0,1,27,0.998,-2.24,4.5,0.926,2.65,0.99982,0.889,0.872
pgkb,1A,rs2108622,0.01,0.778,26.1,0.997,-0.51,2.78,NA,4.025,0.00152,0.305,0.94
pgkb,1A,rs77932196,0.02,0.999,28.2,0.999,-2.88,5.39,0.959,2.93,1,0.885,0.993
pgkb,1A,rs397508256,0.02,0.978,23.9,0.999,-2.19,5.68,0.831,1.95,1,0.692,1
pgkb,1A,rs118192176,0,0.998,24.1,0.994,-3.85,4.63,0.855,2.67,0.99995,0.896,0.998
pgkb,1A,rs267606723,0,1,32,0.997,-7.27,4.67,0.979,5.06,1,0.988,0.999
pgkb,1A,rs1801266,0,1,34,0.999,-3.63,5.03,NA,2.495,1,0.952,0.977
pgkb,1A,rs193922807,0,0.998,23.2,0.996,-6.32,3.99,0.807,2.635,0.99998,0.905,0.996
pgkb,1A,rs193922770,0.05,0.999,27.9,0.997,-3.77,4.01,0.865,2.095,0.99785,0.831,0.991
pgkb,1A,rs28933397,0,0.996,27.8,0.999,-4.64,3.99,0.9,2.585,1,0.922,0.993
pgkb,1A,rs118192178,0,0.992,23.9,0.994,-2.9,4.17,0.915,2.65,0.99314,0.844,0.995
pgkb,1A,rs193922748,0,0.998,34,0.998,-4.99,4.87,0.958,2.965,0.99999,0.951,1
pgkb,1A,rs193922802,0,0.994,25.5,0.996,-4.02,3.82,NA,2.72,0.99995,0.952,0.986
pgkb,1A,rs193922764,0.04,0.976,27.7,0.977,-4.28,4.18,0.889,2.93,0.97896,0.865,0.937
pgkb,1A,rs193922772,0.01,0.994,34,0.999,-3.84,3.76,NA,2.83,0.99997,0.946,0.991
pgkb,1A,rs28933396,0,0.994,24.3,0.997,-5.76,3.99,0.937,2.57,0.99998,0.944,1
pgkb,1A,rs193922878,0.01,0.99,26.6,0.968,-5.44,4.57,0.88,2.15,1,0.882,0.996
pgkb,1A,rs397508442,0,0.981,35,0.999,-2.57,5.85,0.908,4.095,1,0.949,0.397
pgkb,1A,rs118192124,0,0.996,32,0.996,-5.09,3.99,0.828,2.635,0.96594,0.828,0.996
pgkb,1A,rs118192177,0,0.999,25,0.992,-3.69,4.59,0.892,2.47,0.99999,0.968,0.939
pgkb,1A,rs121909041,0.16,0.142,16.62,0.956,-3.31,5.2,0.698,1.94,1,0.555,0.896
pgkb,1A,rs141033578,0,0.918,29.5,0.993,-2.81,5.4,0.857,4.055,1,0.888,1
pgkb,1B,rs3745274,0.37,0.003,0.001,0.689,-0.41,4.48,NA,0.095,1,0.066,0.014
pgkb,1B,rs1050828,0.01,0.202,27.2,0.999,-6.26,5.25,NA,3.365,2.74E-07,0.826,0.937
pgkb,1B,rs121434568,0,0.999,33,0.996,-2.82,5.71,0.888,3.355,1,0.965,1
pgkb,1B,rs2228001,1,0,12.01,0.902,1.93,5.39,NA,-2.455,1,0.095,0.998
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random,random,rs369828654,0,0.866,22.9,0.977,1.94,1.86,NA,2.77,0.96379,0.105,0.028
random,random,rs773524078,0.05,0.015,16.56,0.984,-6.32,5.39,0.67,1.23,0.99835,0.537,1
random,random,rs753432079,0,0.873,25.2,0.998,-5.04,6.07,0.69,0.11,0.99984,0.869,1
random,random,rs148623287,0.45,0.339,0.003,0.515,0.22,4.47,NA,-0.55,1,0.082,0
random,random,rs759769257,0.01,0.015,23.3,0.994,0.9,4.95,0.078,0.895,1,0.084,0.687
random,random,rs769589427,0,0.637,28.2,0.991,-0.51,5.33,0.385,2.82,0.99998,0.446,0.993
random,random,rs770793826,0.09,0.595,25.9,0.994,-3.5,4.98,0.499,1.79,1,0.8,0.992
random,random,rs180887157,0.03,0.857,26.8,0.998,0.57,4.33,NA,2.525,1,0.265,0.918
random,random,rs200734934,0.16,0.398,23.4,0.999,0.67,5.7,NA,2.51,1,0.108,0.956
random,random,rs779943666,0.27,0.138,18.34,0.988,-0.87,4.73,0.481,NA,0.99878,0.267,0.96
random,random,rs757729789,NA,0.007,23,0.993,2.26,5.13,0.361,0.69,0.7155,0.079,0.674
random,random,rs199865930,0.54,0.003,0.003,0.491,2.82,5.5,NA,-0.805,1,0.005,0.002
random,random,rs777988362,0.45,0,0.002,0.548,0.57,5.08,0.349,NA,1,0.056,0
random,random,rs778197519,0.01,0,6.261,0.894,NA,5.13,0.138,NA,0.99235,0.092,0.017
random,random,rs776146773,0.5,0.001,6.933,0.981,1.45,4.91,0.144,0.405,0.98966,0.059,1
random,random,rs141406111,0.69,0,0.136,0.917,-3.65,5.39,NA,0.805,0.99496,0.207,0.448
random,random,rs762553678,0.19,0.005,0.743,0.932,3.13,5.17,0.392,1.83,0.9999,0.06,0.097
random,random,rs779490648,0.6,0,2.016,0.874,0.75,6.03,NA,-0.205,1,0.165,0.832
random,random,rs761540667,0,1,33,1,2.32,4.91,NA,3.615,0.99916,0.471,0.345
random,random,rs769746040,0.15,0.4,12.49,0.809,1.91,5.49,0.395,2.28,0.99995,0.152,0.015
random,random,rs762804918,0.4,0.003,6.587,0.851,NA,3.68,0.097,1.59,1,0.04,0
random,random,rs753951451,0,1,NA,NA,NA,NA,NA,NA,NA,NA,NA
random,random,rs774252706,0.2,0.003,9.56,0.966,-0.89,5.96,0.228,1.645,1,0.182,0.009
random,random,rs551144289,0.03,0.206,22.9,0.856,1.88,3.64,0.499,1.355,0.99657,0.071,0.165
random,random,rs138689221,0.15,0.996,23,0.995,-2.29,4.33,NA,0.55,0.99984,0.549,0.621
random,random,rs75434235,0,0.971,24.8,0.964,-1.04,3.95,0.921,3.725,1,0.884,0.134
random,random,rs758335893,0.03,0.978,28.6,0.998,0.05,5.39,0.349,2.51,1,0.288,1
random,random,rs747977146,0.02,0.081,23.3,0.995,NA,5.61,0.139,0.805,0.93388,0.13,0.817
random,random,rs758026180,0.61,0,21.6,0.986,-0.74,5.24,NA,1.61,0.90255,0.145,0.997
random,random,rs762923706,1,0.014,19.17,0.84,2.47,4.16,NA,0.395,0.9993,0.103,0.995
random,random,rs760174445,0.05,0.023,11.63,0.976,2.32,5.69,0.26,1.845,0.99297,0.028,0.892
random,random,rs767832845,0.23,0.003,8.148,0.964,1.65,5.01,NA,1.14,1,0.046,0.969
random,random,rs367543094,1,0.026,1.012,0.343,NA,4.63,NA,NA,1,0.05,0.962
random,random,rs747272205,0.66,0,10.09,0.796,NA,5.08,0.47,NA,1,0.083,0.989
random,random,rs781071133,0,0.993,20.1,0.919,1.34,1.81,0.662,3.445,0.99093,0.222,0.001
random,random,rs2305993,0.1,0.997,22.8,0.998,NA,5.31,NA,3,1,0.642,0.996
random,random,rs138526931,0.02,0.934,17.87,0.995,1.14,4.85,NA,2.57,0.99998,0.181,0.004
random,random,rs770946033,0,0.942,29.1,0.999,2.37,6.08,0.821,2.595,0.99999,0.581,1
random,random,rs757509976,0.37,0,10.7,0.917,1.16,3.78,0.604,0.685,0.99997,0.033,1
random,random,rs770650463,0.13,0.774,25.8,0.995,NA,5.41,0.229,NA,0.78516,0.128,1
random,random,rs764637824,0,0.996,27.8,0.999,0.65,6.03,0.547,2.78,1,0.391,0.87
random,random,rs374621276,0.17,0.516,16.37,0.992,-0.25,5.02,NA,0.695,1,0.269,1
random,random,rs546975140,0.28,0,0.002,0.319,1.54,3.04,0.229,-0.345,1,0.019,0
random,random,rs769226710,0,0.437,29.8,0.998,-2.21,5.8,0.445,2.875,1,0.742,0.989
random,random,rs773576635,0.11,0.436,18.99,0.969,NA,4.99,0.157,2.25,0.99999,0.099,0.006
random,random,rs781072089,0.14,0.031,19.65,0.958,NA,6.06,0.63,1.7,1,0.34,0.878
random,random,rs372727336,0,0.994,28.7,0.991,-1.35,5.94,NA,4.31,0.99995,0.82,1
random,random,rs745521836,0,0.989,26.2,0.999,-1.18,4.5,0.589,3.52,1,0.635,0.006
random,random,rs753585102,0.06,0.879,24.6,0.998,-0.56,4.45,0.917,4.13,0.64568,0.435,0.988
random,random,rs34447156,0,0.991,31,0.997,3.09,5.86,NA,2.52,1,0.22,1
random,random,rs763367812,0.21,0.013,19.3,0.982,-1.23,5.98,0.525,0.74,0.98,0.169,0.998
random,random,rs371290581,0.01,0.954,26.4,0.998,0.98,5.78,NA,3.525,1,0.68,1
random,random,rs770015994,0.2,0.147,10.37,0.984,-0.26,5.45,0.135,0.205,0.99949,0.217,0.987
random,random,rs779532801,0.1,0.015,20.6,0.991,-1.23,3.96,0.693,1.75,0.95382,0.262,0.027
random,random,rs565842249,0.74,0.009,0.009,0.768,NA,6.04,0.238,0.69,1,0.018,0.001
random,random,rs767901096,0.12,0.967,24.1,0.994,1.78,4.74,0.308,1.21,1,0.164,0.998
random,random,rs568245711,0.39,0,3.356,0.882,-4.61,5.08,0.603,1.16,1,0.345,0.053
random,random,rs730880840,0.39,0.999,24.1,0.999,-2.33,3.28,0.581,0.305,1,0.474,0.925
random,random,rs199731929,0.71,0.561,5.921,0.971,-1.63,5.12,NA,NA,0.99911,0.131,0.563
random,random,rs765580793,0.01,0.95,25.4,0.966,3.17,1.36,0.424,1.97,1,0.037,0.573
random,random,rs779027697,0.01,0.941,23.8,0.989,0.99,5.51,0.579,1.35,1,0.198,0.999
random,random,rs746936940,0.15,0.736,24.3,0.998,5.4,5.56,0.41,2.27,0.9927,0.131,1
random,random,rs759698747,0.04,0.928,32,0.998,0.69,5.22,0.461,1.62,1,0.178,0.99
,,,,,,,,,,,,,
Supplemental Table 2 - Functional inference prediction scores for all 561 PharmGKB missense mutations and 2155 randomly selected common dbSNP variants.,,,,,,,,,,,,,