Variantgroup,PharmGKB evidence level,rs_ID, SIFT Score,PolyPhen Score,CADD Phred Score,DANN Sacore,FATHMM Score,GERP++ NR,MutPred Score,MutationAssessor Score,MutationTaster Score,REVEL Score,PhastCons 20way mammalian
pgkb,3,rs1021737,0,0.206,14.37,0.879,-0.65,4.79,NA,0.695,1,0.12,0.011
pgkb,3,rs1024323,0.07,0.602,17.96,0.978,4.46,4.65,0.571,1.245,1,0.073,0.229
pgkb,2B,rs1042522,0.57,0.045,0.355,0.57,-5.23,1.87,NA,1.355,1,0.368,0.001
pgkb,2A,rs1042713,0.17,0.031,8.198,0.978,-0.17,4.67,NA,0.895,1,0.079,0.729
pgkb,3,rs1042714,0.47,0.009,1.122,0.771,1.19,4.94,NA,1.04,1,0.023,0.928
pgkb,3,rs1042718,0.01,0.955,28.4,0.998,-0.71,5.65,0.746,2.68,0.62139,0.553,0.997
pgkb,3,rs1043620,0,0.975,23.6,0.993,5.17,4.12,0.805,NA,0.99991,0.263,0.999
pgkb,3,rs1044396,0.58,0.209,0.002,0.847,-2.02,4.72,0.429,1.175,1,0.289,0
pgkb,3,rs1047840,0.68,0,0.727,0.411,1.24,5.2,NA,-0.6,1,0.011,0
pgkb,1B,rs1050828,0.01,0.202,27.2,0.999,-6.26,5.25,NA,3.365,2.74E-07,0.826,0.937
pgkb,3,rs1071816,0.13,0,8.641,0.54,NA,3.2,NA,0.205,1,0.134,0
pgkb,3,rs11125,0.01,0.926,23.4,0.995,3.39,6.02,NA,2.48,0.99948,0.13,0.78
pgkb,1A,rs111888148,0,0.998,33,0.998,-3.94,4.01,NA,2.785,0.99499,0.93,1
pgkb,3,rs11209026,0.02,0.995,32,0.999,0.71,5.19,NA,2.535,0.5587,0.177,0.935
pgkb,3,rs1126442,NA,0,NA,NA,NA,NA,NA,NA,NA,NA,NA
pgkb,2B,rs1127354,0.06,0.015,25.1,0.989,NA,5.64,NA,1.39,1.36E-06,0.312,1
pgkb,3,rs1129844,0.07,0.112,3.782,0.81,4.15,4.48,NA,NA,1,0.061,0.019
pgkb,3,rs1131882,0.01,0.007,10.31,0.873,1.11,5.16,NA,NA,0.00077,NA,0.271
pgkb,3,rs1136201,0.75,0.108,13.7,0.942,-1.01,4.97,NA,1.15,0.03033,0.209,0.823
pgkb,3,rs1137101,0.28,0.294,13.22,0.992,0.56,5.96,NA,1.935,0.62243,0.034,0.966
pgkb,3,rs11479,0.14,0.155,24.1,0.985,-1.57,2.19,NA,1.725,2.13E-11,0.322,0.047
pgkb,3,rs11545078,0.06,0.224,23,0.997,0.92,5.93,NA,1.635,1.73E-06,0.191,0.098
pgkb,1A,rs116855232,0.11,0.043,22.2,0.936,2.46,5.39,NA,2.02,0.00463,0.17,0.508
pgkb,3,rs11692021,0.28,0,0.001,0.515,3.39,4.16,NA,0.375,1,0.102,0.002
pgkb,3,rs1176744,1,0,0.604,0.262,-1.05,5.61,NA,-3.235,0.9993,0.247,0.723
pgkb,1A,rs118192124,0,0.996,32,0.996,-5.09,3.99,0.828,2.635,0.96594,0.828,0.996
pgkb,1A,rs118192168,0.08,0.987,25.8,0.977,-4.94,4.57,0.83,0.835,0.99999,0.817,0.997
pgkb,1A,rs118192170,0,0.99,24,0.954,-2.97,5.08,0.906,3.415,1,0.953,0.997
pgkb,1A,rs118192172,0,0.994,35,0.999,-3.86,3.76,NA,2.83,1,0.927,0.979
pgkb,1A,rs118192175,0,0.997,34,0.999,-3.82,4.63,0.964,2.81,1,0.956,0.996
pgkb,1A,rs118192178,0,0.992,23.9,0.994,-2.9,4.17,0.915,2.65,0.99314,0.844,0.995
pgkb,1B,rs121434568,0,0.999,33,0.996,-2.82,5.71,0.888,3.355,1,0.965,1
pgkb,1A,rs121918595,0,0.996,25.9,0.972,-5.07,4.57,0.893,2.99,1,0.977,0.999
pgkb,4,rs12720441,0,0.995,34,0.999,-3.13,4.84,NA,3.79,0.99747,0.944,0.997
pgkb,3,rs12960,0.1,0.179,23.5,0.999,-1.69,5.21,NA,0.695,1.36E-07,0.386,0.348
pgkb,3,rs130072,0.03,0.998,24.7,0.999,3.26,5.07,NA,2.16,0.65852,0.083,0.781
pgkb,3,rs13181,0.45,0,10.56,0.632,-1.42,4.29,NA,-0.165,1,0.205,0.068
pgkb,3,rs1367117,0.01,0.01,23,0.998,1,4.86,NA,1.63,0.81437,0.093,0.997
pgkb,3,rs1650697,1,0,0.001,0.494,-2.04,3.71,NA,-1.1,0.99991,0.242,0
pgkb,3,rs16947,0.35,0.007,NA,NA,NA,4.45,NA,NA,NA,NA,0.48
pgkb,3,rs17602729,0.13,0,20.6,0.956,1.02,4.91,NA,NA,1,0.027,1
pgkb,3,rs17655,0,0.709,24.4,0.988,3.27,4.96,NA,1.975,0.00374,0.172,0.001
pgkb,3,rs17885382,0.15,0.025,18.35,0.994,NA,3.52,NA,1.9,0.99976,0.132,0.006
pgkb,3,rs1799782,0.02,0.999,32,0.999,3.83,4.73,NA,2.39,3.03E-05,0.198,0.997
pgkb,3,rs1799793,0,0.428,33,0.995,-0.17,5.15,0.5,2.8,1,0.576,0.88
pgkb,2B,rs1799971,0.05,0.138,24.1,0.998,2.16,5.75,NA,0.695,0.00305,0.104,0.998
pgkb,3,rs1799972,0.2,0.217,15.5,0.926,2.28,5.61,NA,NA,1,0.092,0.007
pgkb,2B,rs1800497,1,0,0.812,0.174,-0.17,4.42,NA,0.93,1,0.059,0.097
pgkb,2A,rs1800566,0,0.24,32,0.997,3.11,5.41,NA,1.66,1.62E-09,0.366,1
pgkb,4,rs1800888,1,0.012,10.93,0.926,-0.38,5.65,NA,-1.1,0.99893,0.171,0.996
pgkb,3,rs1801058,0.13,0,0.016,0.396,1.86,4.73,NA,NA,1,0.078,0.006
pgkb,3,rs1801131,0.15,0.065,19.89,0.986,-0.78,4.74,NA,1.45,1.65E-06,0.197,0.914
pgkb,2A,rs1801133,0,0.941,25,0.999,-4.03,5.08,NA,2.965,8.64E-08,0.842,0.53
pgkb,3,rs1801252,0.79,0,0.001,0.116,-0.27,4.41,NA,-0.345,1,0.04,0.063
pgkb,3,rs1801253,1,0,0.144,0.662,1.43,3.81,NA,NA,0.9995,0.07,0.989
pgkb,2B,rs1801394,0,0.99,23.3,0.993,-1.04,5.69,NA,2.29,0.99733,0.389,0.996
pgkb,3,rs1801516,0.08,0.335,23.2,0.998,-0.72,5.52,NA,1.82,5.09E-05,0.118,1
pgkb,3,rs1805034,0.88,0.006,13.51,0.195,-0.37,4.99,NA,-0.815,0.99989,0.047,0.924
pgkb,3,rs1805087,0.2,0.21,23.5,0.985,-0.62,5.99,NA,1.495,0.00013,0.34,1
pgkb,3,rs1805128,0.03,0.22,21.8,0.994,-3.13,5.16,NA,2.045,0.99945,0.33,0.004
pgkb,3,rs1870377,0.16,0.011,0.421,0.734,-1.02,5.67,NA,1.625,1,0.17,0.01
pgkb,2B,rs1933437,0.01,0.69,23.8,0.995,-1.23,5.63,NA,0.895,0.50887,0.264,0.613
pgkb,1A,rs193922747,0,0.999,26.9,0.99,-4.95,4.87,0.953,2.93,1,0.947,0.994
pgkb,1A,rs193922753,0,0.996,30,0.985,-4.94,4.26,0.716,2.98,0.99864,0.864,0.915
pgkb,1A,rs193922764,0.04,0.976,27.7,0.977,-4.28,4.18,0.889,2.93,0.97896,0.865,0.937
pgkb,1A,rs193922770,0.05,0.999,27.9,0.997,-3.77,4.01,0.865,2.095,0.99785,0.831,0.991
pgkb,1A,rs193922772,0.01,0.994,34,0.999,-3.84,3.76,NA,2.83,0.99997,0.946,0.991
pgkb,1A,rs193922803,0.01,0.958,34,0.999,-3.88,3.99,0.951,2.645,0.977,0.861,1
pgkb,1A,rs193922809,0.27,0.994,21.2,0.992,-4.76,3.99,NA,0.91,0.99996,0.85,0.989
pgkb,1A,rs193922816,0,0.996,26.7,0.999,-4.65,3.99,0.952,2.635,0.99997,0.913,0.996
pgkb,1A,rs193922818,0,0.994,25.1,0.998,-2.91,4.17,0.946,2.65,0.99958,0.898,0.993
pgkb,1A,rs193922876,0,0.986,25.6,0.966,-4.89,4.57,0.858,3.06,1,0.975,0.99
pgkb,1A,rs193922878,0.01,0.99,26.6,0.968,-5.44,4.57,0.88,2.15,1,0.882,0.996
pgkb,3,rs1979277,0.04,0,12.99,0.979,NA,5.37,NA,1.995,1,0.051,0.036
pgkb,3,rs201929247,0,0.062,8.739,0.982,NA,3.87,NA,2.045,1,0.035,0.015
pgkb,3,rs2071888,0.45,0,2.407,0.176,1.62,4.69,NA,NA,1,0.064,0.194
pgkb,3,rs2073618,1,0,15.99,0.91,-0.58,5.26,NA,-1.87,1,0.155,0.11
pgkb,3,rs2073724,0.1,0.521,13.34,0.986,1.96,5.49,NA,2.14,1,0.043,0.002
pgkb,3,rs2075252,1,0,16.49,0.335,-2.83,5.55,NA,-2.34,0.98295,0.354,0.219
pgkb,3,rs2227956,0.1,0.052,10.97,0.925,5.45,5.55,NA,0.93,1,0.078,0.979
pgkb,3,rs2227983,0.44,0,0.047,0.59,1.63,6.07,NA,0.23,1,0.005,0.247
pgkb,3,rs2228000,0.16,0.003,3.201,0.862,1.24,5.34,NA,1.14,1,0.012,0
pgkb,1B,rs2228001,1,0,12.01,0.902,1.93,5.39,NA,-2.455,1,0.095,0.998
pgkb,3,rs2228171,0.75,0,0.003,0.549,-3.76,6.17,0.327,-0.455,1,0.229,0
pgkb,3,rs2228246,0.41,0,11.23,0.985,0.97,5.69,NA,0.755,0.24164,0.04,1
pgkb,2A,rs2228570,0,0.928,26.1,0.986,-3.26,5.58,0.977,NA,0.99999,0.697,1
pgkb,3,rs2229774,0.11,0.037,22.3,0.995,NA,4.53,NA,1.39,0.09509,0.276,0.982
pgkb,3,rs2236225,0.08,0.026,23.1,0.997,1.98,5.87,NA,0.725,0.02939,0.118,0.995
pgkb,3,rs2241883,0.34,0.001,6.888,0.864,2.61,5.5,NA,2.13,1,0.066,1
pgkb,3,rs2292954,0.15,0.009,14.07,0.978,-3.48,5.42,NA,-0.36,0.99584,0.286,0.982
pgkb,3,rs231775,0.2,0.009,0.003,0.458,1.73,3.94,NA,1.1,1,0.007,0.06
pgkb,3,rs237025,1,0,0.001,0.312,1.53,0.235,NA,NA,2.04E-07,0.079,0.005
pgkb,3,rs2372536,0.11,0.006,21.7,0.986,-1.45,5.87,NA,1.055,1.60E-09,0.321,0.996
pgkb,2B,rs25487,0.6,0,9.117,0.127,2.81,5.16,NA,NA,0.99911,0.072,0.976
pgkb,3,rs2853826,1,0,NA,NA,NA,5.13,NA,NA,NA,NA,0
pgkb,4,rs28933389,0,0.658,25,0.998,-3.7,5.62,NA,2.155,0.99993,0.741,0.762
pgkb,4,rs28933390,0.01,0.056,17.79,0.93,-0.14,5.46,NA,0.235,0.99843,0.077,0.868
pgkb,1A,rs28933397,0,0.996,27.8,0.999,-4.64,3.99,0.9,2.585,1,0.922,0.993
pgkb,3,rs3087374,0.06,0.365,21.1,0.987,-4,5.95,NA,1.1,2.52E-15,0.358,0.998
pgkb,2B,rs3212986,1,0,0.008,0.528,3.03,4.82,NA,-1.59,1,0.028,0.002
pgkb,3,rs3219484,0.1,0.01,17.52,0.972,1.96,4.52,NA,1.35,0.94591,0.073,0.394
pgkb,3,rs324420,0.18,0.027,21.5,0.59,0.61,5.17,NA,1.295,1,0.061,0.965
pgkb,3,rs3775291,0,0.998,23.5,0.997,-1.23,5.78,0.51,3.445,1,0.654,0.336
pgkb,2B,rs396991,0.08,0,0.002,0.38,2.76,5.03,NA,0.16,1,0.064,0
pgkb,3,rs429358,1,0.001,0.007,0.217,-0.24,5.25,NA,-1.465,1,0.229,0.182
pgkb,3,rs4523,NA,0,0.282,0.797,1.07,5.27,NA,NA,0.96251,NA,0.994
pgkb,3,rs462779,0.88,0,6.577,0.102,5.02,5.32,NA,-1.355,1,0.05,0.417
pgkb,3,rs4673,0.28,0.999,11.69,0.994,NA,4.55,NA,NA,0.04624,NA,0.892
pgkb,2A,rs4680,0.07,0.11,11.38,0.978,-0.71,5.33,NA,2.02,0.99993,0.249,0.92
pgkb,3,rs4986790,0.15,0.033,6.513,0.944,2.03,5.78,NA,2.415,7.58E-10,0.079,0.002
pgkb,3,rs4994,1,0,1.055,0.445,1.48,4.42,NA,-2.945,1,0.116,0.956
pgkb,4,rs5030868,0.01,0.029,24.2,0.996,-4.87,5.65,NA,3.42,1,0.811,0.941
pgkb,3,rs5370,0.06,0.071,7.712,0.971,-1.87,5.93,NA,1.32,0.99843,0.164,0.026
pgkb,3,rs540825,0.55,0,2.909,0.09,-0.55,5.4,NA,NA,1,0.113,0.009
pgkb,3,rs557881,0.52,0,0.026,0.508,-0.62,5.63,NA,NA,1,0.057,0
pgkb,3,rs56022120,0.06,0.505,15.26,0.997,1.49,4.59,NA,1.845,1,0.068,0.003
pgkb,3,rs5918,0.28,0.003,0.002,0.425,-3.04,5.88,NA,0.205,1,0.217,0.21
pgkb,2A,rs6025,0,0.897,NA,NA,NA,5.71,NA,NA,NA,NA,0.984
pgkb,2B,rs6065,0.16,0.022,2.224,0.857,0.37,4.81,NA,1.29,1,0.041,0.004
pgkb,3,rs6092,0.32,0.06,13.61,0.983,-1.83,4.84,NA,1.445,0.99922,0.362,0.446
pgkb,3,rs61886492,1,0,8.609,0.306,1.18,3.55,NA,-2.335,0.99996,0.099,0.993
pgkb,3,rs62638690,0.03,0.384,25.1,0.982,1.31,5.8,NA,1.15,1,0.329,1
pgkb,3,rs6265,0.2,0.991,24.1,0.994,0.53,6.16,NA,2.35,9.80E-07,0.134,0.982
pgkb,3,rs6280,1,0,3.761,0.822,-0.56,5,NA,NA,1,0.033,0.392
pgkb,3,rs6314,0.23,0.034,0.047,0.885,0.48,5.73,NA,0.55,1,0.074,0.075
pgkb,3,rs6318,0.28,0,NA,NA,NA,4.57,NA,NA,NA,NA,0.635
pgkb,3,rs6350,0.05,0.796,22.4,0.986,-0.77,4.76,0.395,2.215,0.99981,0.339,0.962
pgkb,3,rs669,0.34,0.02,0.343,0.739,1.21,5.08,NA,1.15,1,0.038,0.685
pgkb,3,rs6785930,0,0.191,21.1,0.997,-0.08,5.02,0.427,1.87,1.39E-13,0.097,0.878
pgkb,3,rs6912029,0,0.398,5.374,0.639,NA,5.69,NA,NA,0.99854,NA,0.002
pgkb,3,rs699,1,0,0.001,0.472,-2.16,5.1,NA,-1.735,1,0.157,0
pgkb,3,rs699664,0.61,0.001,0.94,0.602,-3,5.64,NA,-0.145,1,0.183,0.01
pgkb,3,rs701829,1,0,0.001,0.332,NA,3.87,NA,NA,1,0.117,0.212
pgkb,3,rs710446,1,0,2.234,0.54,2.75,5.61,NA,-2.24,0.99993,0.093,0.002
pgkb,2B,rs738409,0,0.944,22.6,0.993,-1.41,5.7,NA,3.045,0.00029,0.339,0.445
pgkb,2A,rs7412,0,1,30,0.999,-0.89,5.09,NA,2.28,0.93036,0.588,0.965
pgkb,3,rs7572857,0.52,0.003,0.004,0.681,2.17,3.83,NA,-0.255,1,0.008,0.009
pgkb,1A,rs772226819,0,0.996,34,0.999,-4.99,4.48,NA,5.21,0.99992,0.91,0.998
pgkb,3,rs780668,0,0.358,29.1,0.998,0.33,5.53,NA,3.085,6.06E-10,0.286,0.992
pgkb,3,rs79206939,0.52,0.02,14.9,0.855,-1.11,5.46,NA,1.155,0.99974,0.145,0.975
pgkb,3,rs9263726,0.2,0,0.096,0.919,2.77,2.44,NA,NA,1,0.05,0
pgkb,3,rs9274407,0.07,0.372,0.037,0.848,3.44,4.13,0.256,2.725,1,0.116,0.008
Average values,,,0.2695,0.340640845,15.54333577,0.819693431,-0.538671875,4.902021277,0.75275,1.313813559,0.780635749,0.317368421,0.579971631
,,,,,,,,,,,,,
Supplemental Table 3 – Candidate Type B PharmGKB variants.,,,,,,,,,,,,,