{ "cells": [ { "cell_type": "code", "execution_count": 251, "metadata": {}, "outputs": [], "source": [ "#import libraries\n", "import pandas as pd\n", "import numpy as np\n", "from imblearn.over_sampling import ADASYN\n", "import pandas as pd\n", "import imblearn\n", "from imblearn.over_sampling import ADASYN\n", "from collections import Counter\n", "from sklearn.model_selection import train_test_split\n", "from sklearn.linear_model import LogisticRegression\n", "import xgboost as xg\n", "from xgboost import XGBClassifier\n", "from sklearn.decomposition import FastICA\n", "from sklearn.ensemble import RandomForestClassifier\n", "pd.set_option('display.max_columns', None)" ] }, { "cell_type": "code", "execution_count": 252, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGender..female.0..male1.ethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea.VomitingSore.throatRunny.nose.Nasal.congestionLoss.of.smellLoss.of.tasteHeadahceChest.discomfort..chest.painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD.dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic.BPTemperatureTroponinICU.or.not
0230210000000000000010000000000312.2857203.911734540.6960.28188937.00.011
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43012111010000000000000000000002186.73492141.010168817.9980.371513037.10.011
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" ], "text/plain": [ " Age Gender..female.0..male1. ethnicity race Fever Cough SOB Fatigue \\\n", "0 23 0 2 1 0 0 0 0 \n", "1 25 1 3 7 1 1 0 1 \n", "2 28 1 2 1 1 1 1 0 \n", "3 28 1 1 7 1 1 1 0 \n", "4 30 1 2 1 1 1 0 1 \n", "\n", " Sputum Myalgia Diarrhea Nausea.Vomiting Sore.throat \\\n", "0 0 0 0 0 0 \n", "1 1 1 0 0 0 \n", "2 0 0 1 1 1 \n", "3 0 0 0 0 0 \n", "4 0 0 0 0 0 \n", "\n", " Runny.nose.Nasal.congestion Loss.of.smell Loss.of.taste Headahce \\\n", "0 0 0 0 0 \n", "1 0 0 0 1 \n", "2 1 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Chest.discomfort..chest.pain Asymptomatic smoking_history \\\n", "0 0 1 0 \n", "1 1 0 0 \n", "2 1 0 0 \n", "3 0 0 0 \n", "4 0 0 0 \n", "\n", " hypertensionhx diabeteshx asthmahx coronaryheartdiseasehx copdhx \\\n", "0 0 0 0 0 0 \n", "1 0 0 0 0 0 \n", "2 0 0 0 0 0 \n", "3 0 0 0 0 0 \n", "4 0 0 0 0 0 \n", "\n", " heartfailurehx carcinomahx immunosuppressionhx ckdhx ALT CRP \\\n", "0 0 0 0 0 31 2.2 \n", "1 0 0 0 0 37 11.7 \n", "2 0 0 0 0 18 22.0 \n", "3 0 0 0 0 183 10.5 \n", "4 0 0 0 0 218 6.7 \n", "\n", " D.dimer Ferritin HR LDH Lymphocyte SpO2 Procalcitonin RR \\\n", "0 857 203.9 117 345 40.6 96 0.28 18 \n", "1 183 587.1 132 483 6.8 98 0.64 28 \n", "2 389 932.1 124 562 10.4 88 1.81 17 \n", "3 370 2068.0 123 706 13.4 94 0.92 20 \n", "4 349 2141.0 101 688 17.9 98 0.37 15 \n", "\n", " Systolic.BP Temperature Troponin ICU.or.not \n", "0 89 37.0 0.01 1 \n", "1 107 39.5 0.01 1 \n", "2 123 39.1 0.01 1 \n", "3 120 38.9 0.01 1 \n", "4 130 37.1 0.01 1 " ] }, "execution_count": 252, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu = pd.read_csv('ICUMICE2754.csv')\n", "data_icu.head()" ] }, { "cell_type": "code", "execution_count": 253, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea.or.vomitingSore.throatRunny.nose.nasal.congestionLoss.of.smellLoss.of.tasteHeadahceChest.discomfort..Chest.painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD.dimerFerritinHRLDHLymphocytesSpO2ProcalcitoninRRSystolic.BPTemperatureTroponindeath
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2290171110010000000100000000000101.262542.48813315.1970.071910336.90.010
35712111100000000000000000000003412.2206373.96713315.4980.051815337.40.010
42602110000000000000000000000005114.3273107.710014718.3960.431412037.00.010
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" ], "text/plain": [ " Age Gender ethnicity race Fever Cough SOB Fatigue Sputum Myalgia \\\n", "0 23 0 3 7 1 1 1 0 1 0 \n", "1 50 0 1 1 0 1 0 0 0 1 \n", "2 29 0 1 7 1 1 1 0 0 1 \n", "3 57 1 2 1 1 1 1 0 0 0 \n", "4 26 0 2 1 1 0 0 0 0 0 \n", "\n", " Diarrhea Nausea.or.vomiting Sore.throat Runny.nose.nasal.congestion \\\n", "0 1 1 0 0 \n", "1 1 1 0 0 \n", "2 0 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Loss.of.smell Loss.of.taste Headahce Chest.discomfort..Chest.pain \\\n", "0 0 1 0 1 \n", "1 0 0 0 0 \n", "2 0 0 0 1 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Asymptomatic smoking_history hypertensionhx diabeteshx asthmahx \\\n", "0 0 0 0 0 0 \n", "1 0 0 1 1 0 \n", "2 0 0 0 0 0 \n", "3 0 0 0 0 0 \n", "4 0 0 0 0 0 \n", "\n", " coronaryheartdiseasehx copdhx heartfailurehx carcinomahx \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 0 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " immunosuppressionhx ckdhx ALT CRP D.dimer Ferritin HR LDH \\\n", "0 0 0 23 1.7 415 29.1 109 130 \n", "1 0 0 21 5.6 150 153.2 108 130 \n", "2 0 0 10 1.2 625 42.4 88 133 \n", "3 0 0 34 12.2 206 373.9 67 133 \n", "4 0 0 51 14.3 273 107.7 100 147 \n", "\n", " Lymphocytes SpO2 Procalcitonin RR Systolic.BP Temperature Troponin \\\n", "0 30.7 97 0.06 20 102 37.2 0.01 \n", "1 9.2 94 0.08 16 127 37.3 0.01 \n", "2 15.1 97 0.07 19 103 36.9 0.01 \n", "3 15.4 98 0.05 18 153 37.4 0.01 \n", "4 18.3 96 0.43 14 120 37.0 0.01 \n", "\n", " death \n", "0 0 \n", "1 0 \n", "2 0 \n", "3 0 \n", "4 0 " ] }, "execution_count": 253, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_death = pd.read_csv('DeadMICE.csv')\n", "data_death.head()" ] }, { "cell_type": "code", "execution_count": 254, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "(1020, 43)" ] }, "execution_count": 254, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_death.shape" ] }, { "cell_type": "code", "execution_count": 255, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "(1106, 43)" ] }, "execution_count": 255, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu.shape" ] }, { "cell_type": "code", "execution_count": 258, "metadata": {}, "outputs": [], "source": [ "#data_icu['ICU_or_not'].value_counts()/len(data_icu['ICU_or_not'])" ] }, { "cell_type": "code", "execution_count": 259, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 0.860784\n", "1 0.139216\n", "Name: death, dtype: float64" ] }, "execution_count": 259, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_death['death'].value_counts()/len(data_death['death'])" ] }, { "cell_type": "code", "execution_count": 260, "metadata": {}, "outputs": [], "source": [ "#fix the column names\n", "data_icu.columns = data_icu.columns.str.replace('.','_')" ] }, { "cell_type": "code", "execution_count": 261, "metadata": {}, "outputs": [], "source": [ "#fix the gender column\n", "data_icu = data_icu.rename(columns={'Gender__female_0__male1_':'Gender'})" ] }, { "cell_type": "code", "execution_count": 262, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD_dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic_BPTemperatureTroponinICU_or_not
0230210000000000000010000000000312.2857203.911734540.6960.28188937.00.011
12513711011100000011000000000003711.7183587.11324836.8980.642810739.50.011
22812111100011110001000000000001822.0389932.112456210.4881.811712339.10.011
328117111000000000000000000000018310.53702068.012370613.4940.922012038.90.011
43012111010000000000000000000002186.73492141.010168817.9980.371513037.10.011
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" ], "text/plain": [ " Age Gender ethnicity race Fever Cough SOB Fatigue Sputum Myalgia \\\n", "0 23 0 2 1 0 0 0 0 0 0 \n", "1 25 1 3 7 1 1 0 1 1 1 \n", "2 28 1 2 1 1 1 1 0 0 0 \n", "3 28 1 1 7 1 1 1 0 0 0 \n", "4 30 1 2 1 1 1 0 1 0 0 \n", "\n", " Diarrhea Nausea_Vomiting Sore_throat Runny_nose_Nasal_congestion \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 1 1 1 1 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Loss_of_smell Loss_of_taste Headahce Chest_discomfort__chest_pain \\\n", "0 0 0 0 0 \n", "1 0 0 1 1 \n", "2 0 0 0 1 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Asymptomatic smoking_history hypertensionhx diabeteshx asthmahx \\\n", "0 1 0 0 0 0 \n", "1 0 0 0 0 0 \n", "2 0 0 0 0 0 \n", "3 0 0 0 0 0 \n", "4 0 0 0 0 0 \n", "\n", " coronaryheartdiseasehx copdhx heartfailurehx carcinomahx \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 0 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " immunosuppressionhx ckdhx ALT CRP D_dimer Ferritin HR LDH \\\n", "0 0 0 31 2.2 857 203.9 117 345 \n", "1 0 0 37 11.7 183 587.1 132 483 \n", "2 0 0 18 22.0 389 932.1 124 562 \n", "3 0 0 183 10.5 370 2068.0 123 706 \n", "4 0 0 218 6.7 349 2141.0 101 688 \n", "\n", " Lymphocyte SpO2 Procalcitonin RR Systolic_BP Temperature Troponin \\\n", "0 40.6 96 0.28 18 89 37.0 0.01 \n", "1 6.8 98 0.64 28 107 39.5 0.01 \n", "2 10.4 88 1.81 17 123 39.1 0.01 \n", "3 13.4 94 0.92 20 120 38.9 0.01 \n", "4 17.9 98 0.37 15 130 37.1 0.01 \n", "\n", " ICU_or_not \n", "0 1 \n", "1 1 \n", "2 1 \n", "3 1 \n", "4 1 " ] }, "execution_count": 262, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu.head()" ] }, { "cell_type": "code", "execution_count": 263, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "Age 0\n", "Gender 0\n", "ethnicity 0\n", "race 0\n", "Fever 0\n", "Cough 0\n", "SOB 0\n", "Fatigue 0\n", "Sputum 0\n", "Myalgia 0\n", "Diarrhea 0\n", "Nausea_Vomiting 0\n", "Sore_throat 0\n", "Runny_nose_Nasal_congestion 0\n", "Loss_of_smell 0\n", "Loss_of_taste 0\n", "Headahce 0\n", "Chest_discomfort__chest_pain 0\n", "Asymptomatic 0\n", "smoking_history 0\n", "hypertensionhx 0\n", "diabeteshx 0\n", "asthmahx 0\n", "coronaryheartdiseasehx 0\n", "copdhx 0\n", "heartfailurehx 0\n", "carcinomahx 0\n", "immunosuppressionhx 0\n", "ckdhx 0\n", "ALT 0\n", "CRP 0\n", "D_dimer 0\n", "Ferritin 0\n", "HR 0\n", "LDH 0\n", "Lymphocyte 0\n", "SpO2 0\n", "Procalcitonin 0\n", "RR 0\n", "Systolic_BP 0\n", "Temperature 0\n", "Troponin 0\n", "ICU_or_not 0\n", "dtype: int64" ] }, "execution_count": 263, "metadata": {}, "output_type": "execute_result" } ], "source": [ "#checking for missing values\n", "data_icu.isnull().sum()" ] }, { "cell_type": "code", "execution_count": 264, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD_dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic_BPTemperatureTroponinICU_or_not
count1106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.0000001106.000000
mean61.4150090.5732371.8652803.3571430.6663650.6817360.6934900.2323690.0678120.2287520.2350810.2016270.0732370.0452080.0406870.0488250.0967450.1591320.0226040.2486440.4864380.2712480.0596750.1491860.0840870.0723330.0931280.0759490.09132047.66274910.9346931183.9059671119.177758100.138336403.29746814.25922292.6772151.38532522.629295127.98101337.5085900.0319080.245027
std16.9353440.4948310.6244832.8043160.4717240.4660130.4612530.4225340.2515370.4202190.4242420.4013970.2606430.2078540.1976540.2155990.2957440.3659650.1487050.4324220.5000420.4448050.2369900.3564330.2776430.2591550.2907440.2650370.28819499.3082199.4183133995.7801891495.37540949.285812427.3912339.1117626.6193039.9776428.46766624.5599941.3539580.1189700.430298
min22.0000000.0000001.0000001.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000005.0000000.100000150.0000005.3000006.000000120.0000000.30000027.0000000.0200005.00000018.0000003.6000000.0100000.000000
25%50.0000000.0000001.0000001.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.00000018.0000003.700000227.000000327.35000084.000000266.0000007.90000091.0000000.10000018.000000112.00000036.9000000.0100000.000000
50%61.0000001.0000002.0000001.0000001.0000001.0000001.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.00000030.0000008.400000361.000000696.50000098.000000350.00000012.50000094.0000000.17000020.000000125.00000037.3000000.0100000.000000
75%74.0000001.0000002.0000007.0000001.0000001.0000001.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000000.0000001.0000001.0000000.0000000.0000000.0000000.0000000.0000000.0000000.00000054.00000015.550000695.2500001377.500000111.000000470.00000018.60000096.0000000.36000024.000000142.00000038.0000000.0100000.000000
max99.0000001.0000003.0000007.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000001.0000002909.00000056.60000063670.00000022420.0000001288.00000013320.00000072.000000100.000000193.500000165.000000322.00000039.7000002.4000001.000000
\n", "
" ], "text/plain": [ " Age Gender ethnicity race Fever \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 61.415009 0.573237 1.865280 3.357143 0.666365 \n", "std 16.935344 0.494831 0.624483 2.804316 0.471724 \n", "min 22.000000 0.000000 1.000000 1.000000 0.000000 \n", "25% 50.000000 0.000000 1.000000 1.000000 0.000000 \n", "50% 61.000000 1.000000 2.000000 1.000000 1.000000 \n", "75% 74.000000 1.000000 2.000000 7.000000 1.000000 \n", "max 99.000000 1.000000 3.000000 7.000000 1.000000 \n", "\n", " Cough SOB Fatigue Sputum Myalgia \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 0.681736 0.693490 0.232369 0.067812 0.228752 \n", "std 0.466013 0.461253 0.422534 0.251537 0.420219 \n", "min 0.000000 0.000000 0.000000 0.000000 0.000000 \n", "25% 0.000000 0.000000 0.000000 0.000000 0.000000 \n", "50% 1.000000 1.000000 0.000000 0.000000 0.000000 \n", "75% 1.000000 1.000000 0.000000 0.000000 0.000000 \n", "max 1.000000 1.000000 1.000000 1.000000 1.000000 \n", "\n", " Diarrhea Nausea_Vomiting Sore_throat Runny_nose_Nasal_congestion \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 0.235081 0.201627 0.073237 0.045208 \n", "std 0.424242 0.401397 0.260643 0.207854 \n", "min 0.000000 0.000000 0.000000 0.000000 \n", "25% 0.000000 0.000000 0.000000 0.000000 \n", "50% 0.000000 0.000000 0.000000 0.000000 \n", "75% 0.000000 0.000000 0.000000 0.000000 \n", "max 1.000000 1.000000 1.000000 1.000000 \n", "\n", " Loss_of_smell Loss_of_taste Headahce \\\n", "count 1106.000000 1106.000000 1106.000000 \n", "mean 0.040687 0.048825 0.096745 \n", "std 0.197654 0.215599 0.295744 \n", "min 0.000000 0.000000 0.000000 \n", "25% 0.000000 0.000000 0.000000 \n", "50% 0.000000 0.000000 0.000000 \n", "75% 0.000000 0.000000 0.000000 \n", "max 1.000000 1.000000 1.000000 \n", "\n", " Chest_discomfort__chest_pain Asymptomatic smoking_history \\\n", "count 1106.000000 1106.000000 1106.000000 \n", "mean 0.159132 0.022604 0.248644 \n", "std 0.365965 0.148705 0.432422 \n", "min 0.000000 0.000000 0.000000 \n", "25% 0.000000 0.000000 0.000000 \n", "50% 0.000000 0.000000 0.000000 \n", "75% 0.000000 0.000000 0.000000 \n", "max 1.000000 1.000000 1.000000 \n", "\n", " hypertensionhx diabeteshx asthmahx coronaryheartdiseasehx \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 0.486438 0.271248 0.059675 0.149186 \n", "std 0.500042 0.444805 0.236990 0.356433 \n", "min 0.000000 0.000000 0.000000 0.000000 \n", "25% 0.000000 0.000000 0.000000 0.000000 \n", "50% 0.000000 0.000000 0.000000 0.000000 \n", "75% 1.000000 1.000000 0.000000 0.000000 \n", "max 1.000000 1.000000 1.000000 1.000000 \n", "\n", " copdhx heartfailurehx carcinomahx immunosuppressionhx \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 0.084087 0.072333 0.093128 0.075949 \n", "std 0.277643 0.259155 0.290744 0.265037 \n", "min 0.000000 0.000000 0.000000 0.000000 \n", "25% 0.000000 0.000000 0.000000 0.000000 \n", "50% 0.000000 0.000000 0.000000 0.000000 \n", "75% 0.000000 0.000000 0.000000 0.000000 \n", "max 1.000000 1.000000 1.000000 1.000000 \n", "\n", " ckdhx ALT CRP D_dimer Ferritin \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 0.091320 47.662749 10.934693 1183.905967 1119.177758 \n", "std 0.288194 99.308219 9.418313 3995.780189 1495.375409 \n", "min 0.000000 5.000000 0.100000 150.000000 5.300000 \n", "25% 0.000000 18.000000 3.700000 227.000000 327.350000 \n", "50% 0.000000 30.000000 8.400000 361.000000 696.500000 \n", "75% 0.000000 54.000000 15.550000 695.250000 1377.500000 \n", "max 1.000000 2909.000000 56.600000 63670.000000 22420.000000 \n", "\n", " HR LDH Lymphocyte SpO2 Procalcitonin \\\n", "count 1106.000000 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 100.138336 403.297468 14.259222 92.677215 1.385325 \n", "std 49.285812 427.391233 9.111762 6.619303 9.977642 \n", "min 6.000000 120.000000 0.300000 27.000000 0.020000 \n", "25% 84.000000 266.000000 7.900000 91.000000 0.100000 \n", "50% 98.000000 350.000000 12.500000 94.000000 0.170000 \n", "75% 111.000000 470.000000 18.600000 96.000000 0.360000 \n", "max 1288.000000 13320.000000 72.000000 100.000000 193.500000 \n", "\n", " RR Systolic_BP Temperature Troponin ICU_or_not \n", "count 1106.000000 1106.000000 1106.000000 1106.000000 1106.000000 \n", "mean 22.629295 127.981013 37.508590 0.031908 0.245027 \n", "std 8.467666 24.559994 1.353958 0.118970 0.430298 \n", "min 5.000000 18.000000 3.600000 0.010000 0.000000 \n", "25% 18.000000 112.000000 36.900000 0.010000 0.000000 \n", "50% 20.000000 125.000000 37.300000 0.010000 0.000000 \n", "75% 24.000000 142.000000 38.000000 0.010000 0.000000 \n", "max 165.000000 322.000000 39.700000 2.400000 1.000000 " ] }, "execution_count": 264, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu.describe()" ] }, { "cell_type": "code", "execution_count": 265, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "Age int64\n", "Gender int64\n", "ethnicity int64\n", "race int64\n", "Fever int64\n", "Cough int64\n", "SOB int64\n", "Fatigue int64\n", "Sputum int64\n", "Myalgia int64\n", "Diarrhea int64\n", "Nausea_Vomiting int64\n", "Sore_throat int64\n", "Runny_nose_Nasal_congestion int64\n", "Loss_of_smell int64\n", "Loss_of_taste int64\n", "Headahce int64\n", "Chest_discomfort__chest_pain int64\n", "Asymptomatic int64\n", "smoking_history int64\n", "hypertensionhx int64\n", "diabeteshx int64\n", "asthmahx int64\n", "coronaryheartdiseasehx int64\n", "copdhx int64\n", "heartfailurehx int64\n", "carcinomahx int64\n", "immunosuppressionhx int64\n", "ckdhx int64\n", "ALT int64\n", "CRP float64\n", "D_dimer int64\n", "Ferritin float64\n", "HR int64\n", "LDH int64\n", "Lymphocyte float64\n", "SpO2 int64\n", "Procalcitonin float64\n", "RR int64\n", "Systolic_BP int64\n", "Temperature float64\n", "Troponin float64\n", "ICU_or_not int64\n", "dtype: object" ] }, "execution_count": 265, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu.dtypes" ] }, { "cell_type": "code", "execution_count": 266, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "61.41500904159132" ] }, "execution_count": 266, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu['Age'].mean()" ] }, { "cell_type": "code", "execution_count": 267, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 835\n", "1 271\n", "Name: ICU_or_not, dtype: int64" ] }, "execution_count": 267, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_icu['ICU_or_not'].value_counts()" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "#### Symptoms" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "##### No icu" ] }, { "cell_type": "code", "execution_count": 268, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD_dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic_BPTemperatureTroponinICU_or_not
256220211110000110000100010000000100.725685.810619941.3990.111710537.50.010
257221170100010101000001001000000775.9160946.311942412.7960.102013337.80.010
25822121111000100000000000000000016716.82172957.015649913.1920.282312437.40.010
259230211110000000000000001000000377.3150177.011028722.7930.061811636.90.010
26023017111100000011000000000000018014.32661575.015033013.4950.202212637.80.010
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" ], "text/plain": [ " Age Gender ethnicity race Fever Cough SOB Fatigue Sputum \\\n", "256 22 0 2 1 1 1 1 0 0 \n", "257 22 1 1 7 0 1 0 0 0 \n", "258 22 1 2 1 1 1 1 0 0 \n", "259 23 0 2 1 1 1 1 0 0 \n", "260 23 0 1 7 1 1 1 1 0 \n", "\n", " Myalgia Diarrhea Nausea_Vomiting Sore_throat \\\n", "256 0 0 1 1 \n", "257 1 0 1 0 \n", "258 0 1 0 0 \n", "259 0 0 0 0 \n", "260 0 0 0 0 \n", "\n", " Runny_nose_Nasal_congestion Loss_of_smell Loss_of_taste Headahce \\\n", "256 0 0 0 0 \n", "257 1 0 0 0 \n", "258 0 0 0 0 \n", "259 0 0 0 0 \n", "260 0 1 1 0 \n", "\n", " Chest_discomfort__chest_pain Asymptomatic smoking_history \\\n", "256 1 0 0 \n", "257 0 0 1 \n", "258 0 0 0 \n", "259 0 0 0 \n", "260 0 0 0 \n", "\n", " hypertensionhx diabeteshx asthmahx coronaryheartdiseasehx copdhx \\\n", "256 0 1 0 0 0 \n", "257 0 0 1 0 0 \n", "258 0 0 0 0 0 \n", "259 0 0 1 0 0 \n", "260 0 0 0 0 0 \n", "\n", " heartfailurehx carcinomahx immunosuppressionhx ckdhx ALT CRP \\\n", "256 0 0 0 0 10 0.7 \n", "257 0 0 0 0 77 5.9 \n", "258 0 0 0 0 167 16.8 \n", "259 0 0 0 0 37 7.3 \n", "260 0 0 0 0 180 14.3 \n", "\n", " D_dimer Ferritin HR LDH Lymphocyte SpO2 Procalcitonin RR \\\n", "256 256 85.8 106 199 41.3 99 0.11 17 \n", "257 160 946.3 119 424 12.7 96 0.10 20 \n", "258 217 2957.0 156 499 13.1 92 0.28 23 \n", "259 150 177.0 110 287 22.7 93 0.06 18 \n", "260 266 1575.0 150 330 13.4 95 0.20 22 \n", "\n", " Systolic_BP Temperature Troponin ICU_or_not \n", "256 105 37.5 0.01 0 \n", "257 133 37.8 0.01 0 \n", "258 124 37.4 0.01 0 \n", "259 116 36.9 0.01 0 \n", "260 126 37.8 0.01 0 " ] }, "execution_count": 268, "metadata": {}, "output_type": "execute_result" } ], "source": [ "n_icu = data_icu[data_icu['ICU_or_not']==0]\n", "n_icu.head()" ] }, { "cell_type": "code", "execution_count": 269, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "1 0.653892\n", "0 0.346108\n", "Name: Fever, dtype: float64" ] }, "execution_count": 269, "metadata": {}, "output_type": "execute_result" } ], "source": [ "n_icu['Fever'].value_counts()/len(n_icu['Fever'])" ] }, { "cell_type": "code", "execution_count": null, "metadata": {}, "outputs": [], "source": [] }, { "cell_type": "code", "execution_count": 270, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD_dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic_BPTemperatureTroponinICU_or_not
0230210000000000000010000000000312.2857203.911734540.6960.28188937.00.011
12513711011100000011000000000003711.7183587.11324836.8980.642810739.50.011
22812111100011110001000000000001822.0389932.112456210.4881.811712339.10.011
328117111000000000000000000000018310.53702068.012370613.4940.922012038.90.011
43012111010000000000000000000002186.73492141.010168817.9980.371513037.10.011
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" ], "text/plain": [ " Age Gender ethnicity race Fever Cough SOB Fatigue Sputum Myalgia \\\n", "0 23 0 2 1 0 0 0 0 0 0 \n", "1 25 1 3 7 1 1 0 1 1 1 \n", "2 28 1 2 1 1 1 1 0 0 0 \n", "3 28 1 1 7 1 1 1 0 0 0 \n", "4 30 1 2 1 1 1 0 1 0 0 \n", "\n", " Diarrhea Nausea_Vomiting Sore_throat Runny_nose_Nasal_congestion \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 1 1 1 1 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Loss_of_smell Loss_of_taste Headahce Chest_discomfort__chest_pain \\\n", "0 0 0 0 0 \n", "1 0 0 1 1 \n", "2 0 0 0 1 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Asymptomatic smoking_history hypertensionhx diabeteshx asthmahx \\\n", "0 1 0 0 0 0 \n", "1 0 0 0 0 0 \n", "2 0 0 0 0 0 \n", "3 0 0 0 0 0 \n", "4 0 0 0 0 0 \n", "\n", " coronaryheartdiseasehx copdhx heartfailurehx carcinomahx \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 0 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " immunosuppressionhx ckdhx ALT CRP D_dimer Ferritin HR LDH \\\n", "0 0 0 31 2.2 857 203.9 117 345 \n", "1 0 0 37 11.7 183 587.1 132 483 \n", "2 0 0 18 22.0 389 932.1 124 562 \n", "3 0 0 183 10.5 370 2068.0 123 706 \n", "4 0 0 218 6.7 349 2141.0 101 688 \n", "\n", " Lymphocyte SpO2 Procalcitonin RR Systolic_BP Temperature Troponin \\\n", "0 40.6 96 0.28 18 89 37.0 0.01 \n", "1 6.8 98 0.64 28 107 39.5 0.01 \n", "2 10.4 88 1.81 17 123 39.1 0.01 \n", "3 13.4 94 0.92 20 120 38.9 0.01 \n", "4 17.9 98 0.37 15 130 37.1 0.01 \n", "\n", " ICU_or_not \n", "0 1 \n", "1 1 \n", "2 1 \n", "3 1 \n", "4 1 " ] }, "execution_count": 270, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu = data_icu[data_icu['ICU_or_not']==1]\n", "icu.head()" ] }, { "cell_type": "code", "execution_count": 271, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "1 0.704797\n", "0 0.295203\n", "Name: Fever, dtype: float64" ] }, "execution_count": 271, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Fever'].value_counts()/len(icu['Fever'])" ] }, { "cell_type": "code", "execution_count": 272, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "1 0.704797\n", "0 0.295203\n", "Name: Cough, dtype: float64" ] }, "execution_count": 272, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Cough'].value_counts()/len(icu['Cough'])" ] }, { "cell_type": "code", "execution_count": 273, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "1 0.774908\n", "0 0.225092\n", "Name: SOB, dtype: float64" ] }, "execution_count": 273, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['SOB'].value_counts()/len(icu['SOB'])" ] }, { "cell_type": "code", "execution_count": 274, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 0.793358\n", "1 0.206642\n", "Name: Fatigue, dtype: float64" ] }, "execution_count": 274, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Fatigue'].value_counts()/len(icu['Fatigue'])" ] }, { "cell_type": "code", "execution_count": 275, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 246\n", "1 25\n", "Name: Sputum, dtype: int64" ] }, "execution_count": 275, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Sputum'].value_counts()" ] }, { "cell_type": "code", "execution_count": 276, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 210\n", "1 61\n", "Name: Myalgia, dtype: int64" ] }, "execution_count": 276, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Myalgia'].value_counts()" ] }, { "cell_type": "code", "execution_count": 277, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 211\n", "1 60\n", "Name: Diarrhea, dtype: int64" ] }, "execution_count": 277, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Diarrhea'].value_counts()" ] }, { "cell_type": "code", "execution_count": 278, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 223\n", "1 48\n", "Name: Nausea_Vomiting, dtype: int64" ] }, "execution_count": 278, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Nausea_Vomiting'].value_counts()" ] }, { "cell_type": "code", "execution_count": 279, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD_dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic_BPTemperatureTroponinICU_or_not
0230210000000000000010000000000312.2857203.911734540.6960.28188937.00.011
12513711011100000011000000000003711.7183587.11324836.8980.642810739.50.011
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" ], "text/plain": [ " Age Gender ethnicity race Fever Cough SOB Fatigue Sputum Myalgia \\\n", "0 23 0 2 1 0 0 0 0 0 0 \n", "1 25 1 3 7 1 1 0 1 1 1 \n", "\n", " Diarrhea Nausea_Vomiting Sore_throat Runny_nose_Nasal_congestion \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "\n", " Loss_of_smell Loss_of_taste Headahce Chest_discomfort__chest_pain \\\n", "0 0 0 0 0 \n", "1 0 0 1 1 \n", "\n", " Asymptomatic smoking_history hypertensionhx diabeteshx asthmahx \\\n", "0 1 0 0 0 0 \n", "1 0 0 0 0 0 \n", "\n", " coronaryheartdiseasehx copdhx heartfailurehx carcinomahx \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "\n", " immunosuppressionhx ckdhx ALT CRP D_dimer Ferritin HR LDH \\\n", "0 0 0 31 2.2 857 203.9 117 345 \n", "1 0 0 37 11.7 183 587.1 132 483 \n", "\n", " Lymphocyte SpO2 Procalcitonin RR Systolic_BP Temperature Troponin \\\n", "0 40.6 96 0.28 18 89 37.0 0.01 \n", "1 6.8 98 0.64 28 107 39.5 0.01 \n", "\n", " ICU_or_not \n", "0 1 \n", "1 1 " ] }, "execution_count": 279, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu.head(2)" ] }, { "cell_type": "code", "execution_count": 280, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 250\n", "1 21\n", "Name: Sore_throat, dtype: int64" ] }, "execution_count": 280, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Sore_throat'].value_counts()" ] }, { "cell_type": "code", "execution_count": 281, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 257\n", "1 14\n", "Name: Runny_nose_Nasal_congestion, dtype: int64" ] }, "execution_count": 281, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Runny_nose_Nasal_congestion'].value_counts()" ] }, { "cell_type": "code", "execution_count": 282, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 260\n", "1 11\n", "Name: Loss_of_smell, dtype: int64" ] }, "execution_count": 282, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Loss_of_smell'].value_counts()" ] }, { "cell_type": "code", "execution_count": 283, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 259\n", "1 12\n", "Name: Loss_of_taste, dtype: int64" ] }, "execution_count": 283, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Loss_of_taste'].value_counts()" ] }, { "cell_type": "code", "execution_count": 284, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 243\n", "1 28\n", "Name: Headahce, dtype: int64" ] }, "execution_count": 284, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Headahce'].value_counts()" ] }, { "cell_type": "code", "execution_count": 285, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 228\n", "1 43\n", "Name: Chest_discomfort__chest_pain, dtype: int64" ] }, "execution_count": 285, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Chest_discomfort__chest_pain'].value_counts()" ] }, { "cell_type": "code", "execution_count": 286, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 0.98155\n", "1 0.01845\n", "Name: Asymptomatic, dtype: float64" ] }, "execution_count": 286, "metadata": {}, "output_type": "execute_result" } ], "source": [ "icu['Asymptomatic'].value_counts()/len(icu['Asymptomatic'])" ] }, { "cell_type": "code", "execution_count": 287, "metadata": {}, "outputs": [], "source": [ "symptoms = data_icu[['Fever','Cough','SOB','Fatigue','Sputum','Myalgia','Diarrhea','Nausea_Vomiting','Sore_throat','Runny_nose_Nasal_congestion',\n", " 'Loss_of_smell','Loss_of_taste','Headahce','Chest_discomfort__chest_pain','ICU_or_not']]" ] }, { "cell_type": "code", "execution_count": 288, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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FeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painICU_or_not
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" ], "text/plain": [ " Fever Cough SOB Fatigue Sputum Myalgia Diarrhea Nausea_Vomiting \\\n", "0 0 0 0 0 0 0 0 0 \n", "1 1 1 0 1 1 1 0 0 \n", "2 1 1 1 0 0 0 1 1 \n", "3 1 1 1 0 0 0 0 0 \n", "4 1 1 0 1 0 0 0 0 \n", "\n", " Sore_throat Runny_nose_Nasal_congestion Loss_of_smell Loss_of_taste \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 1 1 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Headahce Chest_discomfort__chest_pain ICU_or_not \n", "0 0 0 1 \n", "1 1 1 1 \n", "2 0 1 1 \n", "3 0 0 1 \n", "4 0 0 1 " ] }, "execution_count": 288, "metadata": {}, "output_type": "execute_result" } ], "source": [ "symptoms.head()" ] }, { "cell_type": "code", "execution_count": 289, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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FeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painICU_or_not
Fever1.0000000.4139800.1950580.0306210.0993220.1890490.0983320.0305910.1032260.0524410.1068990.1247200.0953500.1243430.046434
Cough0.4139801.0000000.3667420.0771840.1688430.2057440.1087090.0530870.0654120.0645890.1112380.1277800.1054180.1433500.028205
SOB0.1950580.3667421.0000000.0685970.0311090.0959340.0725740.0017190.0664480.0597080.0872830.0778210.0716260.1605440.100605
Fatigue0.0306210.0771840.0685971.0000000.0048730.1081070.0837250.054328-0.0149710.0348440.0492320.0442280.029957-0.028659-0.034703
Sputum0.0993220.1688430.0311090.0048731.0000000.0072220.054012-0.0369470.0484120.0451670.0536690.0557050.0455480.0989500.055376
Myalgia0.1890490.2057440.0959340.1081070.0072221.0000000.0889590.0911460.0617300.067993-0.0032020.0164550.2222700.039660-0.004964
Diarrhea0.0983320.1087090.0725740.0837250.0540120.0889591.0000000.2209540.0815020.0435750.1664340.2206950.0205300.073594-0.018377
Nausea_Vomiting0.0305910.0530870.0017190.054328-0.0369470.0911460.2209541.0000000.0663300.0316580.0561980.0325440.1023500.052449-0.034796
Sore_throat0.1032260.0654120.066448-0.0149710.0484120.0617300.0815020.0663301.0000000.1893980.0123730.0007280.0606220.1054090.009302
Runny_nose_Nasal_congestion0.0524410.0645890.0597080.0348440.0451670.0679930.0435750.0316580.1893981.000000-0.000757-0.0089100.0612840.0600020.017693
Loss_of_smell0.1068990.1112380.0872830.0492320.053669-0.0032020.1664340.0561980.012373-0.0007571.0000000.8452810.0254900.085564-0.000279
Loss_of_taste0.1247200.1277800.0778210.0442280.0557050.0164550.2206950.0325440.000728-0.0089100.8452811.0000000.0110110.084955-0.012013
Headahce0.0953500.1054180.0716260.0299570.0455480.2222700.0205300.1023500.0606220.0612840.0254900.0110111.0000000.1001110.012673
Chest_discomfort__chest_pain0.1243430.1433500.160544-0.0286590.0989500.0396600.0735940.0524490.1054090.0600020.0855640.0849550.1001111.000000-0.000717
ICU_or_not0.0464340.0282050.100605-0.0347030.055376-0.004964-0.018377-0.0347960.0093020.017693-0.000279-0.0120130.012673-0.0007171.000000
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" ], "text/plain": [ " Fever Cough SOB Fatigue \\\n", "Fever 1.000000 0.413980 0.195058 0.030621 \n", "Cough 0.413980 1.000000 0.366742 0.077184 \n", "SOB 0.195058 0.366742 1.000000 0.068597 \n", "Fatigue 0.030621 0.077184 0.068597 1.000000 \n", "Sputum 0.099322 0.168843 0.031109 0.004873 \n", "Myalgia 0.189049 0.205744 0.095934 0.108107 \n", "Diarrhea 0.098332 0.108709 0.072574 0.083725 \n", "Nausea_Vomiting 0.030591 0.053087 0.001719 0.054328 \n", "Sore_throat 0.103226 0.065412 0.066448 -0.014971 \n", "Runny_nose_Nasal_congestion 0.052441 0.064589 0.059708 0.034844 \n", "Loss_of_smell 0.106899 0.111238 0.087283 0.049232 \n", "Loss_of_taste 0.124720 0.127780 0.077821 0.044228 \n", "Headahce 0.095350 0.105418 0.071626 0.029957 \n", "Chest_discomfort__chest_pain 0.124343 0.143350 0.160544 -0.028659 \n", "ICU_or_not 0.046434 0.028205 0.100605 -0.034703 \n", "\n", " Sputum Myalgia Diarrhea Nausea_Vomiting \\\n", "Fever 0.099322 0.189049 0.098332 0.030591 \n", "Cough 0.168843 0.205744 0.108709 0.053087 \n", "SOB 0.031109 0.095934 0.072574 0.001719 \n", "Fatigue 0.004873 0.108107 0.083725 0.054328 \n", "Sputum 1.000000 0.007222 0.054012 -0.036947 \n", "Myalgia 0.007222 1.000000 0.088959 0.091146 \n", "Diarrhea 0.054012 0.088959 1.000000 0.220954 \n", "Nausea_Vomiting -0.036947 0.091146 0.220954 1.000000 \n", "Sore_throat 0.048412 0.061730 0.081502 0.066330 \n", "Runny_nose_Nasal_congestion 0.045167 0.067993 0.043575 0.031658 \n", "Loss_of_smell 0.053669 -0.003202 0.166434 0.056198 \n", "Loss_of_taste 0.055705 0.016455 0.220695 0.032544 \n", "Headahce 0.045548 0.222270 0.020530 0.102350 \n", "Chest_discomfort__chest_pain 0.098950 0.039660 0.073594 0.052449 \n", "ICU_or_not 0.055376 -0.004964 -0.018377 -0.034796 \n", "\n", " Sore_throat Runny_nose_Nasal_congestion \\\n", "Fever 0.103226 0.052441 \n", "Cough 0.065412 0.064589 \n", "SOB 0.066448 0.059708 \n", "Fatigue -0.014971 0.034844 \n", "Sputum 0.048412 0.045167 \n", "Myalgia 0.061730 0.067993 \n", "Diarrhea 0.081502 0.043575 \n", "Nausea_Vomiting 0.066330 0.031658 \n", "Sore_throat 1.000000 0.189398 \n", "Runny_nose_Nasal_congestion 0.189398 1.000000 \n", "Loss_of_smell 0.012373 -0.000757 \n", "Loss_of_taste 0.000728 -0.008910 \n", "Headahce 0.060622 0.061284 \n", "Chest_discomfort__chest_pain 0.105409 0.060002 \n", "ICU_or_not 0.009302 0.017693 \n", "\n", " Loss_of_smell Loss_of_taste Headahce \\\n", "Fever 0.106899 0.124720 0.095350 \n", "Cough 0.111238 0.127780 0.105418 \n", "SOB 0.087283 0.077821 0.071626 \n", "Fatigue 0.049232 0.044228 0.029957 \n", "Sputum 0.053669 0.055705 0.045548 \n", "Myalgia -0.003202 0.016455 0.222270 \n", "Diarrhea 0.166434 0.220695 0.020530 \n", "Nausea_Vomiting 0.056198 0.032544 0.102350 \n", "Sore_throat 0.012373 0.000728 0.060622 \n", "Runny_nose_Nasal_congestion -0.000757 -0.008910 0.061284 \n", "Loss_of_smell 1.000000 0.845281 0.025490 \n", "Loss_of_taste 0.845281 1.000000 0.011011 \n", "Headahce 0.025490 0.011011 1.000000 \n", "Chest_discomfort__chest_pain 0.085564 0.084955 0.100111 \n", "ICU_or_not -0.000279 -0.012013 0.012673 \n", "\n", " Chest_discomfort__chest_pain ICU_or_not \n", "Fever 0.124343 0.046434 \n", "Cough 0.143350 0.028205 \n", "SOB 0.160544 0.100605 \n", "Fatigue -0.028659 -0.034703 \n", "Sputum 0.098950 0.055376 \n", "Myalgia 0.039660 -0.004964 \n", "Diarrhea 0.073594 -0.018377 \n", "Nausea_Vomiting 0.052449 -0.034796 \n", "Sore_throat 0.105409 0.009302 \n", "Runny_nose_Nasal_congestion 0.060002 0.017693 \n", "Loss_of_smell 0.085564 -0.000279 \n", "Loss_of_taste 0.084955 -0.012013 \n", "Headahce 0.100111 0.012673 \n", "Chest_discomfort__chest_pain 1.000000 -0.000717 \n", "ICU_or_not -0.000717 1.000000 " ] }, "execution_count": 289, "metadata": {}, "output_type": "execute_result" } ], "source": [ "symptoms.corr()" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ "### Statistical Analysis\n" ] }, { "cell_type": "code", "execution_count": 290, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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AgeGenderethnicityraceFeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea_VomitingSore_throatRunny_nose_Nasal_congestionLoss_of_smellLoss_of_tasteHeadahceChest_discomfort__chest_painAsymptomaticsmoking_historyhypertensionhxdiabeteshxasthmahxcoronaryheartdiseasehxcopdhxheartfailurehxcarcinomahximmunosuppressionhxckdhxALTCRPD_dimerFerritinHRLDHLymphocyteSpO2ProcalcitoninRRSystolic_BPTemperatureTroponinICU_or_not
0230210000000000000010000000000312.2857203.911734540.6960.28188937.00.011
12513711011100000011000000000003711.7183587.11324836.8980.642810739.50.011
22812111100011110001000000000001822.0389932.112456210.4881.811712339.10.011
328117111000000000000000000000018310.53702068.012370613.4940.922012038.90.011
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" ], "text/plain": [ " Age Gender ethnicity race Fever Cough SOB Fatigue Sputum Myalgia \\\n", "0 23 0 3 7 1 1 1 0 1 0 \n", "1 50 0 1 1 0 1 0 0 0 1 \n", "2 29 0 1 7 1 1 1 0 0 1 \n", "3 57 1 2 1 1 1 1 0 0 0 \n", "4 26 0 2 1 1 0 0 0 0 0 \n", "\n", " Diarrhea Nausea.or.vomiting Sore.throat Runny.nose.nasal.congestion \\\n", "0 1 1 0 0 \n", "1 1 1 0 0 \n", "2 0 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Loss.of.smell Loss.of.taste Headahce Chest.discomfort..Chest.pain \\\n", "0 0 1 0 1 \n", "1 0 0 0 0 \n", "2 0 0 0 1 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " Asymptomatic smoking_history hypertensionhx diabeteshx asthmahx \\\n", "0 0 0 0 0 0 \n", "1 0 0 1 1 0 \n", "2 0 0 0 0 0 \n", "3 0 0 0 0 0 \n", "4 0 0 0 0 0 \n", "\n", " coronaryheartdiseasehx copdhx heartfailurehx carcinomahx \\\n", "0 0 0 0 0 \n", "1 0 0 0 0 \n", "2 0 0 0 0 \n", "3 0 0 0 0 \n", "4 0 0 0 0 \n", "\n", " immunosuppressionhx ckdhx ALT CRP D.dimer Ferritin HR LDH \\\n", "0 0 0 23 1.7 415 29.1 109 130 \n", "1 0 0 21 5.6 150 153.2 108 130 \n", "2 0 0 10 1.2 625 42.4 88 133 \n", "3 0 0 34 12.2 206 373.9 67 133 \n", "4 0 0 51 14.3 273 107.7 100 147 \n", "\n", " Lymphocytes SpO2 Procalcitonin RR Systolic.BP Temperature Troponin \\\n", "0 30.7 97 0.06 20 102 37.2 0.01 \n", "1 9.2 94 0.08 16 127 37.3 0.01 \n", "2 15.1 97 0.07 19 103 36.9 0.01 \n", "3 15.4 98 0.05 18 153 37.4 0.01 \n", "4 18.3 96 0.43 14 120 37.0 0.01 \n", "\n", " death \n", "0 0 \n", "1 0 \n", "2 0 \n", "3 0 \n", "4 0 " ] }, "execution_count": 325, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_death.head()" ] }, { "cell_type": "code", "execution_count": 326, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "0 878\n", "1 142\n", "Name: death, dtype: int64" ] }, "execution_count": 326, "metadata": {}, "output_type": "execute_result" } ], "source": [ "data_death['death'].value_counts()" ] }, { "cell_type": "code", "execution_count": 327, "metadata": {}, "outputs": [], "source": [ "symptoms_death = data_death[['Fever','Cough','SOB','Fatigue','Sputum','Myalgia','Diarrhea','Nausea.or.vomiting','Sore.throat','Runny.nose.nasal.congestion',\n", " 'Loss.of.smell','Loss.of.taste','Headahce','Chest.discomfort..Chest.pain','death']]" ] }, { "cell_type": "code", "execution_count": 328, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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FeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea.or.vomitingSore.throatRunny.nose.nasal.congestionLoss.of.smellLoss.of.tasteHeadahceChest.discomfort..Chest.paindeath
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" ], "text/plain": [ " Fever Cough SOB Fatigue Sputum Myalgia Diarrhea Nausea.or.vomiting \\\n", "0 1 1 1 0 1 0 1 1 \n", "1 0 1 0 0 0 1 1 1 \n", "2 1 1 1 0 0 1 0 0 \n", "\n", " Sore.throat Runny.nose.nasal.congestion Loss.of.smell Loss.of.taste \\\n", "0 0 0 0 1 \n", "1 0 0 0 0 \n", "2 0 0 0 0 \n", "\n", " Headahce Chest.discomfort..Chest.pain death \n", "0 0 1 0 \n", "1 0 0 0 \n", "2 0 1 0 " ] }, "execution_count": 328, "metadata": {}, "output_type": "execute_result" } ], "source": [ "symptoms_death.head(3)" ] }, { "cell_type": "code", "execution_count": 329, "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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FeverCoughSOBFatigueSputumMyalgiaDiarrheaNausea.or.vomitingSore.throatRunny.nose.nasal.congestionLoss.of.smellLoss.of.tasteHeadahceChest.discomfort..Chest.paindeath
Fever1.0000000.4031820.1816000.0225240.0977540.1903260.0897170.0219280.1040960.0611660.1110530.1223930.0931950.113001-0.081211
Cough0.4031821.0000000.3782860.0889420.1637610.1993320.1068260.0534300.0690480.0629440.1148270.1241480.0949210.159424-0.149239
SOB0.1816000.3782861.0000000.0582470.0303920.1082560.071214-0.0008100.0711900.0542890.0835990.0768790.0684710.1567630.031060
Fatigue0.0225240.0889420.0582471.0000000.0217790.1263860.0848820.050871-0.0114130.0411820.0573860.0483140.038930-0.045296-0.092248
Sputum0.0977540.1637610.0303920.0217791.0000000.0031110.029780-0.0434750.0602340.0191390.0269970.0303390.0349970.1106740.006055
Myalgia0.1903260.1993320.1082560.1263860.0031111.0000000.0738560.0918430.0599500.063858-0.0025870.0159640.1984040.050492-0.119151
Diarrhea0.0897170.1068260.0712140.0848820.0297800.0738561.0000000.2410040.0940410.0287590.1639110.219143-0.0024320.073801-0.040196
Nausea.or.vomiting0.0219280.053430-0.0008100.050871-0.0434750.0918430.2410041.0000000.0587420.0255920.0522840.0359250.0851040.035649-0.128031
Sore.throat0.1040960.0690480.071190-0.0114130.0602340.0599500.0940410.0587421.0000000.1955560.0204900.0056290.0635640.114994-0.037340
Runny.nose.nasal.congestion0.0611660.0629440.0542890.0411820.0191390.0638580.0287590.0255920.1955561.000000-0.018808-0.0266640.0452030.051029-0.031233
Loss.of.smell0.1110530.1148270.0835990.0573860.026997-0.0025870.1639110.0522840.020490-0.0188081.0000000.8430660.0040700.092626-0.052068
Loss.of.taste0.1223930.1241480.0768790.0483140.0303390.0159640.2191430.0359250.005629-0.0266640.8430661.0000000.0045740.088523-0.065071
Headahce0.0931950.0949210.0684710.0389300.0349970.198404-0.0024320.0851040.0635640.0452030.0040700.0045741.0000000.090683-0.061733
Chest.discomfort..Chest.pain0.1130010.1594240.156763-0.0452960.1106740.0504920.0738010.0356490.1149940.0510290.0926260.0885230.0906831.000000-0.096428
death-0.081211-0.1492390.031060-0.0922480.006055-0.119151-0.040196-0.128031-0.037340-0.031233-0.052068-0.065071-0.061733-0.0964281.000000
\n", "
" ], "text/plain": [ " Fever Cough SOB Fatigue \\\n", "Fever 1.000000 0.403182 0.181600 0.022524 \n", "Cough 0.403182 1.000000 0.378286 0.088942 \n", "SOB 0.181600 0.378286 1.000000 0.058247 \n", "Fatigue 0.022524 0.088942 0.058247 1.000000 \n", "Sputum 0.097754 0.163761 0.030392 0.021779 \n", "Myalgia 0.190326 0.199332 0.108256 0.126386 \n", "Diarrhea 0.089717 0.106826 0.071214 0.084882 \n", "Nausea.or.vomiting 0.021928 0.053430 -0.000810 0.050871 \n", "Sore.throat 0.104096 0.069048 0.071190 -0.011413 \n", "Runny.nose.nasal.congestion 0.061166 0.062944 0.054289 0.041182 \n", "Loss.of.smell 0.111053 0.114827 0.083599 0.057386 \n", "Loss.of.taste 0.122393 0.124148 0.076879 0.048314 \n", "Headahce 0.093195 0.094921 0.068471 0.038930 \n", "Chest.discomfort..Chest.pain 0.113001 0.159424 0.156763 -0.045296 \n", "death -0.081211 -0.149239 0.031060 -0.092248 \n", "\n", " Sputum Myalgia Diarrhea \\\n", "Fever 0.097754 0.190326 0.089717 \n", "Cough 0.163761 0.199332 0.106826 \n", "SOB 0.030392 0.108256 0.071214 \n", "Fatigue 0.021779 0.126386 0.084882 \n", "Sputum 1.000000 0.003111 0.029780 \n", "Myalgia 0.003111 1.000000 0.073856 \n", "Diarrhea 0.029780 0.073856 1.000000 \n", "Nausea.or.vomiting -0.043475 0.091843 0.241004 \n", "Sore.throat 0.060234 0.059950 0.094041 \n", "Runny.nose.nasal.congestion 0.019139 0.063858 0.028759 \n", "Loss.of.smell 0.026997 -0.002587 0.163911 \n", "Loss.of.taste 0.030339 0.015964 0.219143 \n", "Headahce 0.034997 0.198404 -0.002432 \n", "Chest.discomfort..Chest.pain 0.110674 0.050492 0.073801 \n", "death 0.006055 -0.119151 -0.040196 \n", "\n", " Nausea.or.vomiting Sore.throat \\\n", "Fever 0.021928 0.104096 \n", "Cough 0.053430 0.069048 \n", "SOB -0.000810 0.071190 \n", "Fatigue 0.050871 -0.011413 \n", "Sputum -0.043475 0.060234 \n", "Myalgia 0.091843 0.059950 \n", "Diarrhea 0.241004 0.094041 \n", "Nausea.or.vomiting 1.000000 0.058742 \n", "Sore.throat 0.058742 1.000000 \n", "Runny.nose.nasal.congestion 0.025592 0.195556 \n", "Loss.of.smell 0.052284 0.020490 \n", "Loss.of.taste 0.035925 0.005629 \n", "Headahce 0.085104 0.063564 \n", "Chest.discomfort..Chest.pain 0.035649 0.114994 \n", "death -0.128031 -0.037340 \n", "\n", " Runny.nose.nasal.congestion Loss.of.smell \\\n", "Fever 0.061166 0.111053 \n", "Cough 0.062944 0.114827 \n", "SOB 0.054289 0.083599 \n", "Fatigue 0.041182 0.057386 \n", "Sputum 0.019139 0.026997 \n", "Myalgia 0.063858 -0.002587 \n", "Diarrhea 0.028759 0.163911 \n", "Nausea.or.vomiting 0.025592 0.052284 \n", "Sore.throat 0.195556 0.020490 \n", "Runny.nose.nasal.congestion 1.000000 -0.018808 \n", "Loss.of.smell -0.018808 1.000000 \n", "Loss.of.taste -0.026664 0.843066 \n", "Headahce 0.045203 0.004070 \n", "Chest.discomfort..Chest.pain 0.051029 0.092626 \n", "death -0.031233 -0.052068 \n", "\n", " Loss.of.taste Headahce \\\n", "Fever 0.122393 0.093195 \n", "Cough 0.124148 0.094921 \n", "SOB 0.076879 0.068471 \n", "Fatigue 0.048314 0.038930 \n", "Sputum 0.030339 0.034997 \n", "Myalgia 0.015964 0.198404 \n", "Diarrhea 0.219143 -0.002432 \n", "Nausea.or.vomiting 0.035925 0.085104 \n", "Sore.throat 0.005629 0.063564 \n", "Runny.nose.nasal.congestion -0.026664 0.045203 \n", "Loss.of.smell 0.843066 0.004070 \n", "Loss.of.taste 1.000000 0.004574 \n", "Headahce 0.004574 1.000000 \n", "Chest.discomfort..Chest.pain 0.088523 0.090683 \n", "death -0.065071 -0.061733 \n", "\n", " Chest.discomfort..Chest.pain death \n", "Fever 0.113001 -0.081211 \n", "Cough 0.159424 -0.149239 \n", "SOB 0.156763 0.031060 \n", "Fatigue -0.045296 -0.092248 \n", "Sputum 0.110674 0.006055 \n", "Myalgia 0.050492 -0.119151 \n", "Diarrhea 0.073801 -0.040196 \n", "Nausea.or.vomiting 0.035649 -0.128031 \n", "Sore.throat 0.114994 -0.037340 \n", "Runny.nose.nasal.congestion 0.051029 -0.031233 \n", "Loss.of.smell 0.092626 -0.052068 \n", "Loss.of.taste 0.088523 -0.065071 \n", "Headahce 0.090683 -0.061733 \n", "Chest.discomfort..Chest.pain 1.000000 -0.096428 \n", "death -0.096428 1.000000 " ] }, "execution_count": 329, "metadata": {}, "output_type": "execute_result" } ], "source": [ "symptoms_death.corr()" ] }, { "cell_type": "code", "execution_count": 330, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "1020" ] }, "execution_count": 330, "metadata": {}, "output_type": "execute_result" } ], "source": [ "len(data_death)" ] }, { "cell_type": "code", "execution_count": 331, "metadata": {}, "outputs": [], "source": [ "import seaborn as sns" ] }, { "cell_type": "code", "execution_count": 332, "metadata": {}, "outputs": [ { "data": { "text/plain": [ "" ] }, "execution_count": 332, "metadata": {}, "output_type": "execute_result" }, { "data": { "image/png": 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\n", 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