geneid chr start end length strand name HeyA8.ULK2OE1_FPKM HeyA8.ULK2OE2_FPKM HeyA8.ULK2OE3_FPKM HeyA8.Control1_FPKM HeyA8.Control2_FPKM HeyA8.Control3_FPKM HeyA8.ULK2OE1_counts_norm HeyA8.ULK2OE2_counts_norm HeyA8.ULK2OE3_counts_norm HeyA8.Control1_counts_norm HeyA8.Control2_counts_norm HeyA8.Control3_counts_norm baseMean log2FC Pvalue Padj trend Description GO Pathway Tumour_Types(Somatic) Tumour_Types(Germline) Translocation_Partner Somatic DBD_Classification PubMed_ID Function Species Evidence_Strength ENSG00000146674 7 45912245 45921874 11661 - IGFBP3 70.23711437 65.8903923 70.62603632 31.05699124 30.98267515 31.40680462 4410.432236 4648.554237 4257.0877 1873.507366 1906.261303 1892.562315 3164.734193 1.231117942 1.44E-29 3.80E-25 UP insulin like growth factor binding protein 3 [Source:HGNC Symbol;Acc:HGNC:5472] [GO:0005576:extracellular region][GO:0005520:insulin-like growth factor binding][GO:0019838:growth factor binding][GO:0001968:fibronectin binding][GO:0001558:regulation of cell growth][GO:0001649:osteoblast differentiation][GO:0010906:regulation of glucose metabolic process][GO:0040008:regulation of growth][GO:0043410:positive regulation of MAPK cascade][GO:0043568:positive regulation of insulin-like growth factor receptor signaling pathway][GO:0044342:type B pancreatic cell proliferation][GO:0005615:extracellular space][GO:0005576:extracellular region][GO:0005520:insulin-like growth factor binding][GO:0005615:extracellular space][GO:0046872:metal ion binding][GO:0006915:apoptotic process][GO:0050790:regulation of catalytic activity][GO:0005576:extracellular region][GO:0009968:negative regulation of signal transduction][GO:0005515:protein binding][GO:0019838:growth factor binding][GO:0043065:positive regulation of apoptotic process][GO:0005615:extracellular space][GO:0005576:extracellular region][GO:0001968:fibronectin binding][GO:0005634:nucleus][GO:0005788:endoplasmic reticulum lumen][GO:0006468:protein phosphorylation][GO:0014912:negative regulation of smooth muscle cell migration][GO:0008285:negative regulation of cell population proliferation][GO:0048662:negative regulation of smooth muscle cell proliferation][GO:0016942:insulin-like growth factor binding protein complex][GO:0042567:insulin-like growth factor ternary complex][GO:0031994:insulin-like growth factor I binding][GO:0005520:insulin-like growth factor binding][GO:0031994:insulin-like growth factor I binding][GO:0031995:insulin-like growth factor II binding][GO:0043567:regulation of insulin-like growth factor receptor signaling pathway][GO:0045663:positive regulation of myoblast differentiation][GO:0001933:negative regulation of protein phosphorylation][GO:0008160:protein tyrosine phosphatase activator activity][GO:0005576:extracellular region][GO:0005520:insulin-like growth factor binding][GO:0005576:extracellular region][GO:0005520:insulin-like growth factor binding][GO:0005576:extracellular region][GO:0005520:insulin-like growth factor binding][GO:0005576:extracellular region][GO:0005520:insulin-like growth factor binding] [hsa04115:p53 signaling pathway][hsa05202:Transcriptional misregulation in cancer] - - - - - - - - - ENSG00000083290 17 19770829 19867936 20677 - ULK2 0.436854698 0.876984908 1.333398001 0.059697985 0.057810823 0.051358243 59.24606174 133.6275211 173.58634 7.777923679 7.682112331 6.68412523 64.76734734 4.050829488 1.48E-17 1.95E-13 UP unc-51 like autophagy activating kinase 2 [Source:HGNC Symbol;Acc:HGNC:13480] [GO:0005524:ATP binding][GO:0007165:signal transduction][GO:0006468:protein phosphorylation][GO:0004674:protein serine/threonine kinase activity][GO:0004672:protein kinase activity][GO:0007409:axonogenesis][GO:0016020:membrane][GO:0000166:nucleotide binding][GO:0004674:protein serine/threonine kinase activity][GO:0016301:kinase activity][GO:0016740:transferase activity][GO:0016310:phosphorylation][GO:0031410:cytoplasmic vesicle][GO:0030659:cytoplasmic vesicle membrane][GO:0006914:autophagy][GO:0006914:autophagy][GO:0007399:nervous system development][GO:0034045:phagophore assembly site membrane][GO:0005737:cytoplasm][GO:0005515:protein binding][GO:0046777:protein autophosphorylation][GO:0004674:protein serine/threonine kinase activity][GO:0000045:autophagosome assembly][GO:0000422:autophagy of mitochondrion][GO:0018105:peptidyl-serine phosphorylation][GO:0044805:late nucleophagy][GO:0042594:response to starvation][GO:0042594:response to starvation][GO:0034727:piecemeal microautophagy of the nucleus][GO:0048671:negative regulation of collateral sprouting][GO:0048675:axon extension][GO:0061709:reticulophagy][GO:0034045:phagophore assembly site membrane][GO:0006914:autophagy][GO:0005524:ATP binding][GO:0007165:signal transduction][GO:0006468:protein phosphorylation][GO:0004674:protein serine/threonine kinase activity][GO:0004672:protein kinase activity][GO:0007409:axonogenesis][GO:0016020:membrane][GO:0000166:nucleotide binding][GO:0004674:protein serine/threonine kinase activity][GO:0016301:kinase activity][GO:0016740:transferase activity][GO:0016310:phosphorylation][GO:0031410:cytoplasmic vesicle][GO:0030659:cytoplasmic vesicle membrane][GO:0006914:autophagy][GO:0006914:autophagy][GO:0007399:nervous system development][GO:0034045:phagophore assembly site membrane][GO:0005737:cytoplasm][GO:0005515:protein binding][GO:0046777:protein autophosphorylation][GO:0004674:protein serine/threonine kinase activity][GO:0000045:autophagosome assembly][GO:0000422:autophagy of mitochondrion][GO:0018105:peptidyl-serine phosphorylation][GO:0044805:late nucleophagy][GO:0042594:response to starvation][GO:0042594:response to starvation][GO:0034727:piecemeal microautophagy of the nucleus][GO:0048671:negative regulation of collateral sprouting][GO:0048675:axon extension][GO:0061709:reticulophagy][GO:0034045:phagophore assembly site membrane][GO:0006914:autophagy][GO:0042594:response to starvation][GO:0048671:negative regulation of collateral sprouting][GO:0048675:axon extension][GO:0034045:phagophore assembly site membrane] [hsa04140:Autophagy - animal][hsa04150:mTOR signaling pathway][hsa04211:Longevity regulating pathway] - - - - - - - - - ENSG00000236675 1 155230975 155234325 838 + MTX1P1 3.71060713 2.439466036 3.225201033 25.13164043 23.04860157 11.49076342 42.73486421 31.56555616 35.65557254 278.0607715 260.0943746 126.9983794 129.1849197 -2.594046016 7.76E-17 6.84E-13 DOWN - - - - - - - - - - - - ENSG00000181634 9 114784652 114806039 9372 - TNFSF15 0.816996525 0.989093542 1.078054217 2.364722669 2.062281104 2.510998238 87.41222224 118.8969282 110.7199358 243.060115 216.1965899 257.8162589 172.3503417 -1.179556276 1.55E-08 4.56E-05 DOWN TNF superfamily member 15 [Source:HGNC Symbol;Acc:HGNC:11931] [GO:0005576:extracellular region][GO:0005515:protein binding][GO:0007165:signal transduction][GO:0016020:membrane][GO:0006955:immune response][GO:0006915:apoptotic process][GO:0005164:tumor necrosis factor receptor binding][GO:0016021:integral component of membrane][GO:0016021:integral component of membrane][GO:0005615:extracellular space][GO:0005515:protein binding][GO:0005125:cytokine activity][GO:0005102:signaling receptor binding][GO:0007166:cell surface receptor signaling pathway][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0007165:signal transduction][GO:0005102:signaling receptor binding][GO:0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process][GO:0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process][GO:0007250:activation of NF-kappaB-inducing kinase activity][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0007165:signal transduction][GO:0016020:membrane][GO:0006955:immune response][GO:0006915:apoptotic process][GO:0005164:tumor necrosis factor receptor binding][GO:0005102:signaling receptor binding][GO:0007166:cell surface receptor signaling pathway] [hsa04060:Cytokine-cytokine receptor interaction] - - - - - - - - - ENSG00000120738 5 138465479 138469303 3137 + EGR1 0.202751608 0.738553462 0.521471442 2.629071074 1.922460628 1.915600027 8.741222224 35.77429698 21.58100443 108.8909315 81.21090179 79.25462773 55.90883078 -2.035687936 4.22E-07 0.000859261 DOWN early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] "[GO:0005515:protein binding][GO:0005737:cytoplasm][GO:0010628:positive regulation of gene expression][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0046872:metal ion binding][GO:0005654:nucleoplasm][GO:0008270:zinc ion binding][GO:0003677:DNA binding][GO:0003677:DNA binding][GO:0003700:DNA-binding transcription factor activity][GO:0043565:sequence-specific DNA binding][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0045893:positive regulation of transcription, DNA-templated][GO:0048511:rhythmic process][GO:0032922:circadian regulation of gene expression][GO:0000977:RNA polymerase II regulatory region sequence-specific DNA binding][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0010385:double-stranded methylated DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:1990837:sequence-specific double-stranded DNA binding][GO:0005654:nucleoplasm][GO:0032731:positive regulation of interleukin-1 beta production][GO:0001666:response to hypoxia][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0032722:positive regulation of chemokine production][GO:0002931:response to ischemia][GO:0070498:interleukin-1-mediated signaling pathway][GO:1990841:promoter-specific chromatin binding][GO:1901216:positive regulation of neuron death][GO:0045475:locomotor rhythm][GO:0071504:cellular response to heparin][GO:1902949:positive regulation of tau-protein kinase activity][GO:1902895:positive regulation of pri-miRNA transcription by RNA polymerase II][GO:0071506:cellular response to mycophenolic acid][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000977:RNA polymerase II regulatory region sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0003700:DNA-binding transcription factor activity][GO:0035035:histone acetyltransferase binding][GO:0044729:hemi-methylated DNA-binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0001666:response to hypoxia][GO:0002931:response to ischemia][GO:0006355:regulation of transcription, DNA-templated][GO:0009749:response to glucose][GO:0030217:T cell differentiation][GO:0030509:BMP signaling pathway][GO:0032722:positive regulation of chemokine production][GO:0032731:positive regulation of interleukin-1 beta production][GO:0032868:response to insulin][GO:0032922:circadian regulation of gene expression][GO:0033233:regulation of protein sumoylation][GO:0035914:skeletal muscle cell differentiation][GO:0042981:regulation of apoptotic process][GO:0044849:estrous cycle][GO:0044849:estrous cycle][GO:0045475:locomotor rhythm][GO:0045893:positive regulation of transcription, DNA-templated][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0046886:positive regulation of hormone biosynthetic process][GO:0046886:positive regulation of hormone biosynthetic process][GO:0060086:circadian temperature homeostasis][GO:0060086:circadian temperature homeostasis][GO:0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia][GO:0071310:cellular response to organic substance][GO:0071480:cellular response to gamma radiation][GO:0072110:glomerular mesangial cell proliferation][GO:0072303:positive regulation of glomerular metanephric mesangial cell proliferation][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0098759:cellular response to interleukin-8][GO:1901216:positive regulation of neuron death][GO:1902949:positive regulation of tau-protein kinase activity][GO:2000182:regulation of progesterone biosynthetic process][GO:2000182:regulation of progesterone biosynthetic process]" [hsa04933:AGE-RAGE signaling pathway in diabetic complications][hsa05020:Prion diseases][hsa05166:HTLV-I infection] - - - - Zinc-coordinating Group/BetaBetaAlpha-zinc finger Family 10049687 Transactivation Human; Mouse Strong ENSG00000168209 10 72273919 72276036 8587 + DDIT4 14.21411943 6.016351347 12.89503368 24.51105385 23.62559031 24.27021668 413.7511853 196.7586334 360.3089436 685.4295242 673.8309959 677.9612733 501.3400926 -1.067848613 9.42E-07 0.001556513 DOWN DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] [GO:0005737:cytoplasm][GO:0005829:cytosol][GO:0009968:negative regulation of signal transduction][GO:0005737:cytoplasm][GO:0009968:negative regulation of signal transduction][GO:0005737:cytoplasm][GO:0009968:negative regulation of signal transduction][GO:0005737:cytoplasm][GO:0005829:cytosol][GO:0005739:mitochondrion][GO:0006915:apoptotic process][GO:0005829:cytosol][GO:0071889:14-3-3 protein binding][GO:0001666:response to hypoxia][GO:0032007:negative regulation of TOR signaling][GO:0032984:protein-containing complex disassembly][GO:0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator][GO:0045820:negative regulation of glycolytic process][GO:0071549:cellular response to dexamethasone stimulus][GO:0072593:reactive oxygen species metabolic process][GO:0005515:protein binding][GO:0051607:defense response to virus][GO:0051607:defense response to virus][GO:0005829:cytosol][GO:0001666:response to hypoxia][GO:0001666:response to hypoxia][GO:0032007:negative regulation of TOR signaling][GO:0032007:negative regulation of TOR signaling][GO:0007420:brain development][GO:0030182:neuron differentiation][GO:0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator][GO:0006915:apoptotic process][GO:0001764:neuron migration][GO:0032006:regulation of TOR signaling][GO:0048011:neurotrophin TRK receptor signaling pathway][GO:1902532:negative regulation of intracellular signal transduction][GO:0033137:negative regulation of peptidyl-serine phosphorylation][GO:0010801:negative regulation of peptidyl-threonine phosphorylation][GO:1901216:positive regulation of neuron death][GO:0071889:14-3-3 protein binding] [hsa04140:Autophagy - animal][hsa04150:mTOR signaling pathway][hsa04151:PI3K-Akt signaling pathway][hsa05206:MicroRNAs in cancer] - - - - - - - - - ENSG00000160179 21 42199689 42297244 27939 + ABCG1 0.773550623 0.445302519 0.824998543 1.984999436 1.398000004 1.608636022 65.07354323 42.08740821 66.61962238 160.4196759 115.231685 129.8630045 96.54915652 -1.219972318 7.99E-06 0.009598961 DOWN ATP binding cassette subfamily G member 1 [Source:HGNC Symbol;Acc:HGNC:73] [GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0016020:membrane][GO:0055085:transmembrane transport][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0005783:endoplasmic reticulum][GO:0005789:endoplasmic reticulum membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0005739:mitochondrion][GO:0000139:Golgi membrane][GO:0042803:protein homodimerization activity][GO:0006869:lipid transport][GO:0120009:intermembrane lipid transfer][GO:0010033:response to organic substance][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0034204:lipid translocation][GO:0046982:protein heterodimerization activity][GO:0009897:external side of plasma membrane][GO:0050714:positive regulation of protein secretion][GO:1901998:toxin transport][GO:0033344:cholesterol efflux][GO:0042632:cholesterol homeostasis][GO:0005524:ATP binding][GO:1902004:positive regulation of amyloid-beta formation][GO:0042632:cholesterol homeostasis][GO:0019534:toxin transmembrane transporter activity][GO:0015485:cholesterol binding][GO:0008203:cholesterol metabolic process][GO:0033344:cholesterol efflux][GO:0033344:cholesterol efflux][GO:0005543:phospholipid binding][GO:0034375:high-density lipoprotein particle remodeling][GO:0043691:reverse cholesterol transport][GO:0090554:phosphatidylcholine-translocating ATPase activity][GO:0120020:intermembrane cholesterol transfer activity][GO:0010745:negative regulation of macrophage derived foam cell differentiation][GO:0010887:negative regulation of cholesterol storage][GO:0032367:intracellular cholesterol transport][GO:0033700:phospholipid efflux][GO:0055091:phospholipid homeostasis][GO:0043531:ADP binding][GO:0034374:low-density lipoprotein particle remodeling][GO:0055037:recycling endosome][GO:0045542:positive regulation of cholesterol biosynthetic process][GO:0005768:endosome][GO:0033993:response to lipid][GO:0034041:sterol-transporting ATPase activity][GO:0034041:sterol-transporting ATPase activity][GO:0010872:regulation of cholesterol esterification][GO:0034436:glycoprotein transport][GO:0042987:amyloid precursor protein catabolic process][GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0016020:membrane][GO:0055085:transmembrane transport][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0005783:endoplasmic reticulum][GO:0005789:endoplasmic reticulum membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0005739:mitochondrion][GO:0000139:Golgi membrane][GO:0042803:protein homodimerization activity][GO:0006869:lipid transport][GO:0120009:intermembrane lipid transfer][GO:0010033:response to organic substance][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0034204:lipid translocation][GO:0046982:protein heterodimerization activity][GO:0009897:external side of plasma membrane][GO:0050714:positive regulation of protein secretion][GO:1901998:toxin transport][GO:0033344:cholesterol efflux][GO:0042632:cholesterol homeostasis][GO:0005524:ATP binding][GO:1902004:positive regulation of amyloid-beta formation][GO:0042632:cholesterol homeostasis][GO:0019534:toxin transmembrane transporter activity][GO:0015485:cholesterol binding][GO:0008203:cholesterol metabolic process][GO:0033344:cholesterol efflux][GO:0033344:cholesterol efflux][GO:0005543:phospholipid binding][GO:0034375:high-density lipoprotein particle remodeling][GO:0043691:reverse cholesterol transport][GO:0090554:phosphatidylcholine-translocating ATPase activity][GO:0120020:intermembrane cholesterol transfer activity][GO:0010745:negative regulation of macrophage derived foam cell differentiation][GO:0010887:negative regulation of cholesterol storage][GO:0032367:intracellular cholesterol transport][GO:0033700:phospholipid efflux][GO:0055091:phospholipid homeostasis][GO:0043531:ADP binding][GO:0034374:low-density lipoprotein particle remodeling][GO:0055037:recycling endosome][GO:0045542:positive regulation of cholesterol biosynthetic process][GO:0005768:endosome][GO:0033993:response to lipid][GO:0034041:sterol-transporting ATPase activity][GO:0034041:sterol-transporting ATPase activity][GO:0010872:regulation of cholesterol esterification][GO:0034436:glycoprotein transport][GO:0042987:amyloid precursor protein catabolic process][GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0120009:intermembrane lipid transfer][GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0016020:membrane][GO:0055085:transmembrane transport][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0005783:endoplasmic reticulum][GO:0005789:endoplasmic reticulum membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0005739:mitochondrion][GO:0000139:Golgi membrane][GO:0042803:protein homodimerization activity][GO:0006869:lipid transport][GO:0120009:intermembrane lipid transfer][GO:0010033:response to organic substance][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0034204:lipid translocation][GO:0046982:protein heterodimerization activity][GO:0009897:external side of plasma membrane][GO:0050714:positive regulation of protein secretion][GO:1901998:toxin transport][GO:0033344:cholesterol efflux][GO:0042632:cholesterol homeostasis][GO:0005524:ATP binding][GO:1902004:positive regulation of amyloid-beta formation][GO:0042632:cholesterol homeostasis][GO:0019534:toxin transmembrane transporter activity][GO:0015485:cholesterol binding][GO:0008203:cholesterol metabolic process][GO:0033344:cholesterol efflux][GO:0033344:cholesterol efflux][GO:0005543:phospholipid binding][GO:0034375:high-density lipoprotein particle remodeling][GO:0043691:reverse cholesterol transport][GO:0090554:phosphatidylcholine-translocating ATPase activity][GO:0120020:intermembrane cholesterol transfer activity][GO:0010745:negative regulation of macrophage derived foam cell differentiation][GO:0010887:negative regulation of cholesterol storage][GO:0032367:intracellular cholesterol transport][GO:0033700:phospholipid efflux][GO:0055091:phospholipid homeostasis][GO:0043531:ADP binding][GO:0034374:low-density lipoprotein particle remodeling][GO:0055037:recycling endosome][GO:0045542:positive regulation of cholesterol biosynthetic process][GO:0005768:endosome][GO:0033993:response to lipid][GO:0034041:sterol-transporting ATPase activity][GO:0034041:sterol-transporting ATPase activity][GO:0010872:regulation of cholesterol esterification][GO:0034436:glycoprotein transport][GO:0042987:amyloid precursor protein catabolic process][GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0016020:membrane][GO:0055085:transmembrane transport][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0005783:endoplasmic reticulum][GO:0005789:endoplasmic reticulum membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0005739:mitochondrion][GO:0000139:Golgi membrane][GO:0042803:protein homodimerization activity][GO:0006869:lipid transport][GO:0005515:protein binding][GO:0120009:intermembrane lipid transfer][GO:0010033:response to organic substance][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0034204:lipid translocation][GO:0046982:protein heterodimerization activity][GO:0009897:external side of plasma membrane][GO:0050714:positive regulation of protein secretion][GO:1901998:toxin transport][GO:0033344:cholesterol efflux][GO:0042632:cholesterol homeostasis][GO:0005524:ATP binding][GO:1902004:positive regulation of amyloid-beta formation][GO:0042632:cholesterol homeostasis][GO:0019534:toxin transmembrane transporter activity][GO:0015485:cholesterol binding][GO:0008203:cholesterol metabolic process][GO:0033344:cholesterol efflux][GO:0033344:cholesterol efflux][GO:0005543:phospholipid binding][GO:0034375:high-density lipoprotein particle remodeling][GO:0043691:reverse cholesterol transport][GO:0090554:phosphatidylcholine-translocating ATPase activity][GO:0120020:intermembrane cholesterol transfer activity][GO:0010745:negative regulation of macrophage derived foam cell differentiation][GO:0010887:negative regulation of cholesterol storage][GO:0032367:intracellular cholesterol transport][GO:0033700:phospholipid efflux][GO:0055091:phospholipid homeostasis][GO:0043531:ADP binding][GO:0034374:low-density lipoprotein particle remodeling][GO:0055037:recycling endosome][GO:0045542:positive regulation of cholesterol biosynthetic process][GO:0005768:endosome][GO:0033993:response to lipid][GO:0034041:sterol-transporting ATPase activity][GO:0034041:sterol-transporting ATPase activity][GO:0010872:regulation of cholesterol esterification][GO:0010872:regulation of cholesterol esterification][GO:0010875:positive regulation of cholesterol efflux][GO:0010888:negative regulation of lipid storage][GO:0030301:cholesterol transport][GO:0033344:cholesterol efflux][GO:0034374:low-density lipoprotein particle remodeling][GO:0034375:high-density lipoprotein particle remodeling][GO:0034436:glycoprotein transport][GO:0042987:amyloid precursor protein catabolic process][GO:0043691:reverse cholesterol transport][GO:0045542:positive regulation of cholesterol biosynthetic process][GO:0071403:cellular response to high density lipoprotein particle stimulus][GO:0005768:endosome][GO:0009897:external side of plasma membrane][GO:0055037:recycling endosome][GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0016020:membrane][GO:0055085:transmembrane transport][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0005783:endoplasmic reticulum][GO:0005789:endoplasmic reticulum membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0005739:mitochondrion][GO:0000139:Golgi membrane][GO:0042803:protein homodimerization activity][GO:0006869:lipid transport][GO:0120009:intermembrane lipid transfer][GO:0010033:response to organic substance][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0034204:lipid translocation][GO:0046982:protein heterodimerization activity][GO:0009897:external side of plasma membrane][GO:0050714:positive regulation of protein secretion][GO:1901998:toxin transport][GO:0033344:cholesterol efflux][GO:0042632:cholesterol homeostasis][GO:0005524:ATP binding][GO:1902004:positive regulation of amyloid-beta formation][GO:0042632:cholesterol homeostasis][GO:0019534:toxin transmembrane transporter activity][GO:0015485:cholesterol binding][GO:0008203:cholesterol metabolic process][GO:0033344:cholesterol efflux][GO:0033344:cholesterol efflux][GO:0005543:phospholipid binding][GO:0034375:high-density lipoprotein particle remodeling][GO:0043691:reverse cholesterol transport][GO:0090554:phosphatidylcholine-translocating ATPase activity][GO:0120020:intermembrane cholesterol transfer activity][GO:0010745:negative regulation of macrophage derived foam cell differentiation][GO:0010887:negative regulation of cholesterol storage][GO:0032367:intracellular cholesterol transport][GO:0033700:phospholipid efflux][GO:0055091:phospholipid homeostasis][GO:0043531:ADP binding][GO:0034374:low-density lipoprotein particle remodeling][GO:0055037:recycling endosome][GO:0045542:positive regulation of cholesterol biosynthetic process][GO:0005768:endosome][GO:0033993:response to lipid][GO:0034041:sterol-transporting ATPase activity][GO:0034041:sterol-transporting ATPase activity][GO:0010872:regulation of cholesterol esterification][GO:0034436:glycoprotein transport][GO:0042987:amyloid precursor protein catabolic process][GO:0016021:integral component of membrane][GO:0005524:ATP binding][GO:0016020:membrane][GO:0055085:transmembrane transport][GO:0120020:intermembrane cholesterol transfer activity][GO:0032367:intracellular cholesterol transport][GO:0000166:nucleotide binding][GO:0071702:organic substance transport][GO:0120009:intermembrane lipid transfer][GO:0046983:protein dimerization activity] [hsa02010:ABC transporters] - - - - - - - - - ENSG00000152463 10 15032227 15073853 7231 + OLAH 0.060557155 0 0.121892322 0.567898179 0.733261185 1.054676638 1.942493828 0 3.753218162 17.50032828 23.04633699 32.46575112 13.1180214 -3.644028796 1.27E-05 0.013460526 DOWN oleoyl-ACP hydrolase [Source:HGNC Symbol;Acc:HGNC:25625] [GO:0009058:biosynthetic process][GO:0006631:fatty acid metabolic process][GO:0006633:fatty acid biosynthetic process][GO:0004320:oleoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016297:acyl-[acyl-carrier-protein] hydrolase activity][GO:0009058:biosynthetic process][GO:0009058:biosynthetic process][GO:0006631:fatty acid metabolic process][GO:0006633:fatty acid biosynthetic process][GO:0004320:oleoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016297:acyl-[acyl-carrier-protein] hydrolase activity][GO:0009058:biosynthetic process][GO:0005737:cytoplasm][GO:0016787:hydrolase activity][GO:0006629:lipid metabolic process][GO:0006631:fatty acid metabolic process][GO:0005829:cytosol][GO:0005829:cytosol][GO:0006633:fatty acid biosynthetic process][GO:0004320:oleoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016297:acyl-[acyl-carrier-protein] hydrolase activity][GO:0016290:palmitoyl-CoA hydrolase activity][GO:0102991:myristoyl-CoA hydrolase activity][GO:0008610:lipid biosynthetic process][GO:0047381:dodecanoyl-[acyl-carrier-protein] hydrolase activity][GO:0051792:medium-chain fatty acid biosynthetic process][GO:0051792:medium-chain fatty acid biosynthetic process][GO:0009058:biosynthetic process][GO:0006631:fatty acid metabolic process][GO:0006633:fatty acid biosynthetic process][GO:0004320:oleoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016297:acyl-[acyl-carrier-protein] hydrolase activity][GO:0009058:biosynthetic process][GO:0005737:cytoplasm][GO:0016787:hydrolase activity][GO:0006629:lipid metabolic process][GO:0006631:fatty acid metabolic process][GO:0005829:cytosol][GO:0005829:cytosol][GO:0006633:fatty acid biosynthetic process][GO:0004320:oleoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016295:myristoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016296:palmitoyl-[acyl-carrier-protein] hydrolase activity][GO:0016297:acyl-[acyl-carrier-protein] hydrolase activity][GO:0016290:palmitoyl-CoA hydrolase activity][GO:0102991:myristoyl-CoA hydrolase activity][GO:0008610:lipid biosynthetic process][GO:0047381:dodecanoyl-[acyl-carrier-protein] hydrolase activity][GO:0051792:medium-chain fatty acid biosynthetic process] [hsa00061:Fatty acid biosynthesis] - - - - - - - - - ENSG00000100867 14 23630115 23645639 19668 + DHRS2 0 0.045265323 0 0.176095968 0.184063323 0.298181736 0 5.260926026 0 17.50032828 18.65655852 29.60112602 11.83648981 -3.707819837 6.66E-05 0.055010602 DOWN dehydrogenase/reductase 2 [Source:HGNC Symbol;Acc:HGNC:18349] [GO:0016491:oxidoreductase activity][GO:0005654:nucleoplasm][GO:0005739:mitochondrion][GO:0016491:oxidoreductase activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0043066:negative regulation of apoptotic process][GO:0005654:nucleoplasm][GO:0005739:mitochondrion][GO:0005739:mitochondrion][GO:0005759:mitochondrial matrix][GO:0005635:nuclear envelope][GO:0005515:protein binding][GO:0008207:C21-steroid hormone metabolic process][GO:0008285:negative regulation of cell population proliferation][GO:0034599:cellular response to oxidative stress][GO:0009636:response to toxic substance][GO:0043011:myeloid dendritic cell differentiation][GO:0004090:carbonyl reductase (NADPH) activity][GO:0022900:electron transport chain][GO:0016491:oxidoreductase activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0043066:negative regulation of apoptotic process][GO:0005654:nucleoplasm][GO:0005739:mitochondrion][GO:0005739:mitochondrion][GO:0005759:mitochondrial matrix][GO:0005635:nuclear envelope][GO:0005515:protein binding][GO:0008207:C21-steroid hormone metabolic process][GO:0008285:negative regulation of cell population proliferation][GO:0034599:cellular response to oxidative stress][GO:0009636:response to toxic substance][GO:0043011:myeloid dendritic cell differentiation][GO:0004090:carbonyl reductase (NADPH) activity][GO:0022900:electron transport chain][GO:0016491:oxidoreductase activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0043066:negative regulation of apoptotic process][GO:0005654:nucleoplasm][GO:0005739:mitochondrion][GO:0005739:mitochondrion][GO:0005759:mitochondrial matrix][GO:0005635:nuclear envelope][GO:0005515:protein binding][GO:0008207:C21-steroid hormone metabolic process][GO:0008285:negative regulation of cell population proliferation][GO:0034599:cellular response to oxidative stress][GO:0009636:response to toxic substance][GO:0043011:myeloid dendritic cell differentiation][GO:0004090:carbonyl reductase (NADPH) activity][GO:0022900:electron transport chain][GO:0016491:oxidoreductase activity][GO:0005654:nucleoplasm][GO:0005739:mitochondrion][GO:0016491:oxidoreductase activity][GO:0005654:nucleoplasm][GO:0005739:mitochondrion] - - - - - - - - - - ENSG00000160201 21 43092956 43107570 19842 - U2AF1 3.127450916 3.685033867 0.628226109 0.451315687 0.176288584 0.313224116 476.8822347 631.3111231 91.95384497 66.11235127 26.33867085 45.83400158 223.0720377 3.1161695 0.000131779 0.094175949 UP U2 small nuclear RNA auxiliary factor 1 [Source:HGNC Symbol;Acc:HGNC:12453] "[GO:0046872:metal ion binding][GO:0003723:RNA binding][GO:0003676:nucleic acid binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0016607:nuclear speck][GO:0016607:nuclear speck][GO:0005654:nucleoplasm][GO:0005515:protein binding][GO:0000398:mRNA splicing, via spliceosome][GO:0071013:catalytic step 2 spliceosome][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005681:spliceosomal complex][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0089701:U2AF][GO:0015030:Cajal body][GO:0003723:RNA binding][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0003676:nucleic acid binding][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0016607:nuclear speck][GO:0016607:nuclear speck][GO:0046872:metal ion binding][GO:0005654:nucleoplasm][GO:0005515:protein binding][GO:0000398:mRNA splicing, via spliceosome][GO:0000398:mRNA splicing, via spliceosome][GO:0071013:catalytic step 2 spliceosome][GO:0089701:U2AF][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005681:spliceosomal complex][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0089701:U2AF][GO:0015030:Cajal body][GO:0046872:metal ion binding][GO:0003723:RNA binding][GO:0003676:nucleic acid binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0016607:nuclear speck][GO:0016607:nuclear speck][GO:0005654:nucleoplasm][GO:0005515:protein binding][GO:0000398:mRNA splicing, via spliceosome][GO:0071013:catalytic step 2 spliceosome][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005681:spliceosomal complex][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0089701:U2AF][GO:0015030:Cajal body][GO:0046872:metal ion binding][GO:0003723:RNA binding][GO:0003676:nucleic acid binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0016607:nuclear speck][GO:0016607:nuclear speck][GO:0005654:nucleoplasm][GO:0005515:protein binding][GO:0000398:mRNA splicing, via spliceosome][GO:0071013:catalytic step 2 spliceosome][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005681:spliceosomal complex][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0089701:U2AF][GO:0015030:Cajal body][GO:0003723:RNA binding][GO:0046872:metal ion binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF]" [hsa03040:Spliceosome][hsa05131:Shigellosis] "CLL, MDS" yes - - - - - ENSG00000175197 12 57516588 57521737 5377 - DDIT3 2.973879853 1.511958776 1.4148649 5.74676459 4.489491586 3.877606308 53.41858026 30.51337095 24.39591805 99.1685269 79.01601255 66.8412523 58.89227684 -1.177386016 0.000844094 0.344744813 DOWN DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] "[GO:0006355:regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0006915:apoptotic process][GO:0003677:DNA binding][GO:0003677:DNA binding][GO:0045892:negative regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0006355:regulation of transcription, DNA-templated][GO:0016055:Wnt signaling pathway][GO:0005515:protein binding][GO:0006986:response to unfolded protein][GO:0006986:response to unfolded protein][GO:0007049:cell cycle][GO:0045893:positive regulation of transcription, DNA-templated][GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process][GO:0005737:cytoplasm][GO:0042802:identical protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0034976:response to endoplasmic reticulum stress][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0032757:positive regulation of interleukin-8 production][GO:0120163:negative regulation of cold-induced thermogenesis][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0046982:protein heterodimerization activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0005829:cytosol][GO:0010506:regulation of autophagy][GO:0003700:DNA-binding transcription factor activity][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0006357:regulation of transcription by RNA polymerase II][GO:0008140:cAMP response element binding protein binding][GO:0036500:ATF6-mediated unfolded protein response][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway][GO:0043525:positive regulation of neuron apoptotic process][GO:0006974:cellular response to DNA damage stimulus][GO:0008140:cAMP response element binding protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0008134:transcription factor binding][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0030968:endoplasmic reticulum unfolded protein response][GO:0009948:anterior/posterior axis specification][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:0036499:PERK-mediated unfolded protein response][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0042803:protein homodimerization activity][GO:0046982:protein heterodimerization activity][GO:0051898:negative regulation of protein kinase B signaling][GO:0043618:regulation of transcription from RNA polymerase II promoter in response to stress][GO:0036488:CHOP-C/EBP complex][GO:0036488:CHOP-C/EBP complex][GO:0003700:DNA-binding transcription factor activity][GO:0003700:DNA-binding transcription factor activity][GO:0032689:negative regulation of interferon-gamma production][GO:0032088:negative regulation of NF-kappaB transcription factor activity][GO:1990622:CHOP-ATF3 complex][GO:0043522:leucine zipper domain binding][GO:1990617:CHOP-ATF4 complex][GO:1990617:CHOP-ATF4 complex][GO:1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding][GO:0005667:transcription factor complex][GO:0032993:protein-DNA complex][GO:0043525:positive regulation of neuron apoptotic process][GO:0032700:negative regulation of interleukin-17 production][GO:0032713:negative regulation of interleukin-4 production][GO:0045454:cell redox homeostasis][GO:0006983:ER overload response][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:2000016:negative regulation of determination of dorsal identity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0036488:CHOP-C/EBP complex][GO:1990617:CHOP-ATF4 complex][GO:1990622:CHOP-ATF3 complex][GO:0006355:regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0006915:apoptotic process][GO:0003677:DNA binding][GO:0003677:DNA binding][GO:0045892:negative regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0006355:regulation of transcription, DNA-templated][GO:0016055:Wnt signaling pathway][GO:0005515:protein binding][GO:0006986:response to unfolded protein][GO:0006986:response to unfolded protein][GO:0007049:cell cycle][GO:0045893:positive regulation of transcription, DNA-templated][GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process][GO:0005737:cytoplasm][GO:0042802:identical protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0034976:response to endoplasmic reticulum stress][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0032757:positive regulation of interleukin-8 production][GO:0120163:negative regulation of cold-induced thermogenesis][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0046982:protein heterodimerization activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0005829:cytosol][GO:0010506:regulation of autophagy][GO:0003700:DNA-binding transcription factor activity][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0006357:regulation of transcription by RNA polymerase II][GO:0008140:cAMP response element binding protein binding][GO:0036500:ATF6-mediated unfolded protein response][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway][GO:0043525:positive regulation of neuron apoptotic process][GO:0006974:cellular response to DNA damage stimulus][GO:0008140:cAMP response element binding protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0008134:transcription factor binding][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0030968:endoplasmic reticulum unfolded protein response][GO:0009948:anterior/posterior axis specification][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:0036499:PERK-mediated unfolded protein response][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0042803:protein homodimerization activity][GO:0046982:protein heterodimerization activity][GO:0051898:negative regulation of protein kinase B signaling][GO:0043618:regulation of transcription from RNA polymerase II promoter in response to stress][GO:0036488:CHOP-C/EBP complex][GO:0036488:CHOP-C/EBP complex][GO:0003700:DNA-binding transcription factor activity][GO:0003700:DNA-binding transcription factor activity][GO:0032689:negative regulation of interferon-gamma production][GO:0032088:negative regulation of NF-kappaB transcription factor activity][GO:1990622:CHOP-ATF3 complex][GO:0043522:leucine zipper domain binding][GO:1990617:CHOP-ATF4 complex][GO:1990617:CHOP-ATF4 complex][GO:1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding][GO:0005667:transcription factor complex][GO:0032993:protein-DNA complex][GO:0043525:positive regulation of neuron apoptotic process][GO:0032700:negative regulation of interleukin-17 production][GO:0032713:negative regulation of interleukin-4 production][GO:0045454:cell redox homeostasis][GO:0006983:ER overload response][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:2000016:negative regulation of determination of dorsal identity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0036488:CHOP-C/EBP complex][GO:1990617:CHOP-ATF4 complex][GO:1990622:CHOP-ATF3 complex][GO:0006355:regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0006915:apoptotic process][GO:0003677:DNA binding][GO:0003677:DNA binding][GO:0045892:negative regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0006355:regulation of transcription, DNA-templated][GO:0016055:Wnt signaling pathway][GO:0005515:protein binding][GO:0006986:response to unfolded protein][GO:0006986:response to unfolded protein][GO:0007049:cell cycle][GO:0045893:positive regulation of transcription, DNA-templated][GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process][GO:0005737:cytoplasm][GO:0042802:identical protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0034976:response to endoplasmic reticulum stress][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0032757:positive regulation of interleukin-8 production][GO:0120163:negative regulation of cold-induced thermogenesis][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0046982:protein heterodimerization activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0005829:cytosol][GO:0010506:regulation of autophagy][GO:0003700:DNA-binding transcription factor activity][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0006357:regulation of transcription by RNA polymerase II][GO:0008140:cAMP response element binding protein binding][GO:0036500:ATF6-mediated unfolded protein response][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway][GO:0043525:positive regulation of neuron apoptotic process][GO:0006974:cellular response to DNA damage stimulus][GO:0008140:cAMP response element binding protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0008134:transcription factor binding][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0030968:endoplasmic reticulum unfolded protein response][GO:0009948:anterior/posterior axis specification][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:0036499:PERK-mediated unfolded protein response][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0042803:protein homodimerization activity][GO:0046982:protein heterodimerization activity][GO:0051898:negative regulation of protein kinase B signaling][GO:0043618:regulation of transcription from RNA polymerase II promoter in response to stress][GO:0036488:CHOP-C/EBP complex][GO:0036488:CHOP-C/EBP complex][GO:0003700:DNA-binding transcription factor activity][GO:0003700:DNA-binding transcription factor activity][GO:0032689:negative regulation of interferon-gamma production][GO:0032088:negative regulation of NF-kappaB transcription factor activity][GO:1990622:CHOP-ATF3 complex][GO:0043522:leucine zipper domain binding][GO:1990617:CHOP-ATF4 complex][GO:1990617:CHOP-ATF4 complex][GO:1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding][GO:0005667:transcription factor complex][GO:0032993:protein-DNA complex][GO:0043525:positive regulation of neuron apoptotic process][GO:0032700:negative regulation of interleukin-17 production][GO:0032713:negative regulation of interleukin-4 production][GO:0045454:cell redox homeostasis][GO:0006983:ER overload response][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:2000016:negative regulation of determination of dorsal identity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0036488:CHOP-C/EBP complex][GO:1990617:CHOP-ATF4 complex][GO:1990622:CHOP-ATF3 complex][GO:0006355:regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0006915:apoptotic process][GO:0003677:DNA binding][GO:0003677:DNA binding][GO:0045892:negative regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0006355:regulation of transcription, DNA-templated][GO:0016055:Wnt signaling pathway][GO:0005515:protein binding][GO:0006986:response to unfolded protein][GO:0006986:response to unfolded protein][GO:0007049:cell cycle][GO:0045893:positive regulation of transcription, DNA-templated][GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process][GO:0005737:cytoplasm][GO:0042802:identical protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0034976:response to endoplasmic reticulum stress][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0032757:positive regulation of interleukin-8 production][GO:0120163:negative regulation of cold-induced thermogenesis][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0046982:protein heterodimerization activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0005829:cytosol][GO:0010506:regulation of autophagy][GO:0003700:DNA-binding transcription factor activity][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0006357:regulation of transcription by RNA polymerase II][GO:0008140:cAMP response element binding protein binding][GO:0036500:ATF6-mediated unfolded protein response][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway][GO:0043525:positive regulation of neuron apoptotic process][GO:0006974:cellular response to DNA damage stimulus][GO:0008140:cAMP response element binding protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0008134:transcription factor binding][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0030968:endoplasmic reticulum unfolded protein response][GO:0009948:anterior/posterior axis specification][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:0036499:PERK-mediated unfolded protein response][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0042803:protein homodimerization activity][GO:0046982:protein heterodimerization activity][GO:0051898:negative regulation of protein kinase B signaling][GO:0043618:regulation of transcription from RNA polymerase II promoter in response to stress][GO:0036488:CHOP-C/EBP complex][GO:0036488:CHOP-C/EBP complex][GO:0003700:DNA-binding transcription factor activity][GO:0003700:DNA-binding transcription factor activity][GO:0032689:negative regulation of interferon-gamma production][GO:0032088:negative regulation of NF-kappaB transcription factor activity][GO:1990622:CHOP-ATF3 complex][GO:0043522:leucine zipper domain binding][GO:1990617:CHOP-ATF4 complex][GO:1990617:CHOP-ATF4 complex][GO:1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding][GO:0005667:transcription factor complex][GO:0032993:protein-DNA complex][GO:0043525:positive regulation of neuron apoptotic process][GO:0032700:negative regulation of interleukin-17 production][GO:0032713:negative regulation of interleukin-4 production][GO:0045454:cell redox homeostasis][GO:0000976:transcription regulatory region sequence-specific DNA binding][GO:0008140:cAMP response element binding protein binding][GO:0046982:protein heterodimerization activity][GO:0061629:RNA polymerase II-specific DNA-binding transcription factor binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0001955:blood vessel maturation][GO:0006983:ER overload response][GO:0006983:ER overload response][GO:0007605:sensory perception of sound][GO:0009948:anterior/posterior axis specification][GO:0030968:endoplasmic reticulum unfolded protein response][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0032792:negative regulation of CREB transcription factor activity][GO:0034976:response to endoplasmic reticulum stress][GO:0042594:response to starvation][GO:0043392:negative regulation of DNA binding][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:0043525:positive regulation of neuron apoptotic process][GO:0045599:negative regulation of fat cell differentiation][GO:0045662:negative regulation of myoblast differentiation][GO:0045892:negative regulation of transcription, DNA-templated][GO:0045893:positive regulation of transcription, DNA-templated][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:0051091:positive regulation of DNA-binding transcription factor activity][GO:0051209:release of sequestered calcium ion into cytosol][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0072655:establishment of protein localization to mitochondrion][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0120163:negative regulation of cold-induced thermogenesis][GO:1901216:positive regulation of neuron death][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990442:intrinsic apoptotic signaling pathway in response to nitrosative stress][GO:2000016:negative regulation of determination of dorsal identity][GO:2000016:negative regulation of determination of dorsal identity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0005770:late endosome][GO:0036488:CHOP-C/EBP complex][GO:0036488:CHOP-C/EBP complex][GO:0090575:RNA polymerase II transcription factor complex][GO:1990617:CHOP-ATF4 complex][GO:1990622:CHOP-ATF3 complex][GO:0006355:regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0006915:apoptotic process][GO:0003677:DNA binding][GO:0003677:DNA binding][GO:0045892:negative regulation of transcription, DNA-templated][GO:0003700:DNA-binding transcription factor activity][GO:0006355:regulation of transcription, DNA-templated][GO:0016055:Wnt signaling pathway][GO:0005515:protein binding][GO:0006986:response to unfolded protein][GO:0006986:response to unfolded protein][GO:0007049:cell cycle][GO:0045893:positive regulation of transcription, DNA-templated][GO:0043161:proteasome-mediated ubiquitin-dependent protein catabolic process][GO:0005737:cytoplasm][GO:0042802:identical protein binding][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0034976:response to endoplasmic reticulum stress][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0032757:positive regulation of interleukin-8 production][GO:0120163:negative regulation of cold-induced thermogenesis][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0046982:protein heterodimerization activity][GO:0043433:negative regulation of DNA-binding transcription factor activity][GO:2001244:positive regulation of intrinsic apoptotic signaling pathway][GO:0005829:cytosol][GO:0010506:regulation of autophagy][GO:0003700:DNA-binding transcription factor activity][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress][GO:0090090:negative regulation of canonical Wnt signaling pathway][GO:0006357:regulation of transcription by RNA polymerase II][GO:0008140:cAMP response element binding protein binding][GO:0036500:ATF6-mediated unfolded protein response][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress][GO:1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]" [hsa04010:MAPK signaling pathway][hsa04141:Protein processing in endoplasmic reticulum][hsa04210:Apoptosis][hsa04932:Non-alcoholic fatty liver disease (NAFLD)][hsa05202:Transcriptional misregulation in cancer] liposarcoma "FUS, EWSR1" yes - - - - - ENSG00000288538 11 78223815 78225909 1753 + - 0.322510893 0.466462644 0.324582636 1.344209267 1.441185988 0.99122121 7.769975311 12.62622246 7.506436324 31.11169471 34.02078318 22.91700079 19.32535213 -1.663141055 0.001836569 0.500644806 DOWN - - - - - - - - - - - - ENSG00000161265 19 35742464 35745445 19908 - U2AF1L4 0.270390328 0.782156449 0.197910734 0 0.056693387 0.125913825 10.68371605 34.72211177 7.506436324 0 2.194889238 4.774375164 9.980254758 2.912540764 0.002270849 0.551095104 UP U2 small nuclear RNA auxiliary factor 1 like 4 [Source:HGNC Symbol;Acc:HGNC:23020] "[GO:0046872:metal ion binding][GO:0003723:RNA binding][GO:0003676:nucleic acid binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005737:cytoplasm][GO:0016607:nuclear speck][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0046872:metal ion binding][GO:0003723:RNA binding][GO:0003676:nucleic acid binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005737:cytoplasm][GO:0016607:nuclear speck][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0003723:RNA binding][GO:0046872:metal ion binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0046872:metal ion binding][GO:0003723:RNA binding][GO:0003676:nucleic acid binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF][GO:0005634:nucleus][GO:0005681:spliceosomal complex][GO:0006397:mRNA processing][GO:0008380:RNA splicing][GO:0005737:cytoplasm][GO:0016607:nuclear speck][GO:0005654:nucleoplasm][GO:0005681:spliceosomal complex][GO:0000398:mRNA splicing, via spliceosome][GO:0030628:pre-mRNA 3'-splice site binding][GO:0089701:U2AF][GO:0003723:RNA binding][GO:0046872:metal ion binding][GO:0000398:mRNA splicing, via spliceosome][GO:0089701:U2AF]" [hsa03040:Spliceosome][hsa05131:Shigellosis] - - - - - - - - - ENSG00000163702 3 9917074 9933630 44626 + IL17RC 0.856136777 0.24014949 0.548314087 1.184038517 1.400164309 1.148200956 53.41858026 16.83496328 32.84065892 70.97355357 85.60068026 68.75100237 54.73657311 -1.121882493 0.003120579 0.625108807 DOWN interleukin 17 receptor C [Source:HGNC Symbol;Acc:HGNC:18358] [GO:0030368:interleukin-17 receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0006954:inflammatory response][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0006954:inflammatory response][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0019221:cytokine-mediated signaling pathway][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0019221:cytokine-mediated signaling pathway][GO:0019221:cytokine-mediated signaling pathway][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0006954:inflammatory response][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0019221:cytokine-mediated signaling pathway][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0006954:inflammatory response][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0019221:cytokine-mediated signaling pathway][GO:0019221:cytokine-mediated signaling pathway][GO:0030368:interleukin-17 receptor activity][GO:0019221:cytokine-mediated signaling pathway][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0006954:inflammatory response][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0006954:inflammatory response][GO:0005886:plasma membrane][GO:0005515:protein binding][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0030368:interleukin-17 receptor activity][GO:0019221:cytokine-mediated signaling pathway] [hsa04060:Cytokine-cytokine receptor interaction][hsa04657:IL-17 signaling pathway] - - - - - - - - - ENSG00000135114 12 121017763 121039242 19211 - OASL 0.134290165 0.10790565 0.191466491 0.43144674 0.438778981 0.321015452 11.65496297 10.52185205 15.95117719 35.97289701 37.31311704 26.73650092 23.02508453 -1.385112575 0.00386623 0.66817557 DOWN 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] [GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0005515:protein binding][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0003677:DNA binding][GO:0005730:nucleolus][GO:0005730:nucleolus][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0051607:defense response to virus][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0046966:thyroid hormone receptor binding][GO:0045071:negative regulation of viral genome replication][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:0070106:interleukin-27-mediated signaling pathway][GO:1900246:positive regulation of RIG-I signaling pathway][GO:0005515:protein binding][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0003677:DNA binding][GO:0005730:nucleolus][GO:0005730:nucleolus][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0051607:defense response to virus][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0046966:thyroid hormone receptor binding][GO:0045071:negative regulation of viral genome replication][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:1900246:positive regulation of RIG-I signaling pathway][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0003677:DNA binding][GO:0005730:nucleolus][GO:0005730:nucleolus][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0051607:defense response to virus][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0046966:thyroid hormone receptor binding][GO:0045071:negative regulation of viral genome replication][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:1900246:positive regulation of RIG-I signaling pathway][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0043231:intracellular membrane-bounded organelle] - - - - - - - - - - ENSG00000219682 6 25140003 25141403 1401 + - 0.403541467 1.36187559 0.812267468 0.210242581 0.174511227 0.206710776 7.769975311 29.46118575 15.01287265 3.888961839 3.292333856 3.819500132 10.54080492 2.239691968 0.004617167 0.71560459 UP - - - - - - - - - - - - ENSG00000201699 1 149162783 149162944 162 - RNVU1-24 5.234829587 39.11879548 12.29306644 6.363731449 2.515331577 8.938327062 11.65496297 97.85322409 26.27252713 13.61136644 5.487223094 19.09750066 28.99613406 1.817082818 0.00587122 0.794006405 UP - - - - - - - - - - - - ENSG00000120669 13 36168217 36214588 4034 - SOHLH2 0 0 0 0.131378169 0.072700038 0.129171185 0 0 0 5.833442759 3.292333856 5.729250197 2.475837802 -4.774056798 0.006424997 0.823674674 DOWN spermatogenesis and oogenesis specific basic helix-loop-helix 2 [Source:HGNC Symbol;Acc:HGNC:26026] "[GO:0006355:regulation of transcription, DNA-templated][GO:0007283:spermatogenesis][GO:0046983:protein dimerization activity][GO:0048477:oogenesis][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0003677:DNA binding][GO:0030154:cell differentiation][GO:0030154:cell differentiation][GO:0042803:protein homodimerization activity][GO:0007283:spermatogenesis][GO:0005634:nucleus][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0030154:cell differentiation][GO:1990837:sequence-specific double-stranded DNA binding][GO:0046982:protein heterodimerization activity][GO:0009994:oocyte differentiation][GO:0006355:regulation of transcription, DNA-templated][GO:0007283:spermatogenesis][GO:0048477:oogenesis][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0046983:protein dimerization activity][GO:0003677:DNA binding][GO:0030154:cell differentiation][GO:0030154:cell differentiation][GO:0042803:protein homodimerization activity][GO:0007283:spermatogenesis][GO:0005634:nucleus][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0030154:cell differentiation][GO:1990837:sequence-specific double-stranded DNA binding][GO:0046982:protein heterodimerization activity][GO:0009994:oocyte differentiation]" - - - - - - - - - - ENSG00000174564 3 136946230 137011085 6986 + IL20RB 0.752118373 0.446286814 0.524042187 1.386542505 1.334371561 1.215070985 25.25241976 16.83496328 16.88948173 44.72306115 43.89778475 39.14987635 31.12459784 -1.113575684 0.006564565 0.826572453 DOWN interleukin 20 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:6004] [GO:0005515:protein binding][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005515:protein binding][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0016021:integral component of membrane][GO:0019221:cytokine-mediated signaling pathway][GO:0004896:cytokine receptor activity][GO:0042015:interleukin-20 binding][GO:0001808:negative regulation of type IV hypersensitivity][GO:0002437:inflammatory response to antigenic stimulus][GO:0002765:immune response-inhibiting signal transduction][GO:0032689:negative regulation of interferon-gamma production][GO:0032703:negative regulation of interleukin-2 production][GO:0032733:positive regulation of interleukin-10 production][GO:0032753:positive regulation of interleukin-4 production][GO:0042130:negative regulation of T cell proliferation][GO:0048873:homeostasis of number of cells within a tissue][GO:0050863:regulation of T cell activation][GO:0016020:membrane][GO:0016021:integral component of membrane] [hsa04060:Cytokine-cytokine receptor interaction][hsa04630:Jak-STAT signaling pathway] - - - - - - - - - ENSG00000211450 11 57741491 57743554 5510 + SELENOH 0.821746505 0.132058949 0.447972002 1.355728502 1.066091116 1.543420429 23.30992593 4.208740821 12.19795903 36.94513747 29.63100471 42.01450145 24.71787823 -1.444807706 0.006923675 0.83319517 DOWN selenoprotein H [Source:HGNC Symbol;Acc:HGNC:18251] [GO:0003723:RNA binding][GO:0005794:Golgi apparatus][GO:0003723:RNA binding][GO:0005794:Golgi apparatus] - - - - - - - - - - ENSG00000112182 6 89926528 90296908 26439 - BACH2 0.122753999 0.076587984 0.10174092 0.353628365 0.183194886 0.236723651 16.51119753 11.57403726 13.13626357 45.69530161 24.14378161 30.55600105 23.60276377 -1.285361934 0.008166007 0.89386488 DOWN BTB domain and CNC homolog 2 [Source:HGNC Symbol;Acc:HGNC:14078] "[GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005515:protein binding][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0005515:protein binding][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:1990837:sequence-specific double-stranded DNA binding][GO:0051170:import into nucleus][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0051170:import into nucleus][GO:0090721:primary adaptive immune response involving T cells and B cells][GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005515:protein binding][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0005515:protein binding][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:1990837:sequence-specific double-stranded DNA binding][GO:0051170:import into nucleus][GO:0090721:primary adaptive immune response involving T cells and B cells][GO:0005515:protein binding][GO:0005515:protein binding][GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005515:protein binding][GO:0003700:DNA-binding transcription factor activity][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0005515:protein binding][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:1990837:sequence-specific double-stranded DNA binding][GO:0051170:import into nucleus][GO:0090721:primary adaptive immune response involving T cells and B cells]" - - - - - Zipper-Type Group/Leucine Zipper Family 10949928 DNA Binding Human Strong ENSG00000115339 2 165747588 165794659 11104 - GALNT3 0.138599214 0.178188933 0.294477933 0.706046723 0.42621962 0.473308668 8.741222224 12.62622246 17.82778627 42.77858023 26.33867085 28.64625099 22.8264555 -1.317917725 0.008197441 0.89386488 DOWN polypeptide N-acetylgalactosaminyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:4125] "[GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005794:Golgi apparatus][GO:0046872:metal ion binding][GO:0016740:transferase activity][GO:0030246:carbohydrate binding][GO:0005794:Golgi apparatus][GO:0016757:transferase activity, transferring glycosyl groups][GO:0006486:protein glycosylation][GO:0004653:polypeptide N-acetylgalactosaminyltransferase activity][GO:0005794:Golgi apparatus][GO:0032580:Golgi cisterna membrane][GO:0070062:extracellular exosome][GO:0016021:integral component of membrane][GO:0000139:Golgi membrane][GO:0005975:carbohydrate metabolic process][GO:0016020:membrane][GO:0048471:perinuclear region of cytoplasm][GO:0005509:calcium ion binding][GO:0006493:protein O-linked glycosylation][GO:0016266:O-glycan processing][GO:0030145:manganese ion binding][GO:0004653:polypeptide N-acetylgalactosaminyltransferase activity][GO:0004653:polypeptide N-acetylgalactosaminyltransferase activity][GO:0004653:polypeptide N-acetylgalactosaminyltransferase activity][GO:0004653:polypeptide N-acetylgalactosaminyltransferase activity][GO:0018242:protein O-linked glycosylation via serine][GO:0018243:protein O-linked glycosylation via threonine][GO:0006493:protein O-linked glycosylation][GO:0007283:spermatogenesis][GO:0008543:fibroblast growth factor receptor signaling pathway][GO:0016740:transferase activity][GO:0030246:carbohydrate binding][GO:0034645:cellular macromolecule biosynthetic process][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005794:Golgi apparatus][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0016020:membrane][GO:0016021:integral component of membrane]" [hsa00512:Mucin type O-glycan biosynthesis] - - - - - - - - - ENSG00000049249 1 7915871 7943165 13478 - TNFRSF9 0.233565343 0.096519006 0.111936056 0.370852824 0.410433708 0.364622974 20.39618519 9.469666847 9.383045405 31.11169471 35.1182278 30.55600105 22.67247017 -1.29874546 0.009086047 0.916997142 DOWN TNF receptor superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11924] [GO:0005515:protein binding][GO:0038023:signaling receptor activity][GO:0006915:apoptotic process][GO:0008285:negative regulation of cell population proliferation][GO:0009897:external side of plasma membrane][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005515:protein binding][GO:0009897:external side of plasma membrane][GO:0005886:plasma membrane][GO:0038023:signaling receptor activity][GO:0042127:regulation of cell population proliferation][GO:0005887:integral component of plasma membrane][GO:0038023:signaling receptor activity][GO:0008285:negative regulation of cell population proliferation][GO:0006915:apoptotic process][GO:0019955:cytokine binding][GO:0042127:regulation of cell population proliferation][GO:0038023:signaling receptor activity][GO:0006915:apoptotic process][GO:0008285:negative regulation of cell population proliferation][GO:0009897:external side of plasma membrane][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0006915:apoptotic process][GO:0008285:negative regulation of cell population proliferation][GO:0009897:external side of plasma membrane][GO:0038023:signaling receptor activity][GO:0005515:protein binding][GO:0038023:signaling receptor activity][GO:0006915:apoptotic process][GO:0008285:negative regulation of cell population proliferation][GO:0009897:external side of plasma membrane][GO:0050794:regulation of cellular process][GO:0005515:protein binding][GO:0038023:signaling receptor activity][GO:0006915:apoptotic process][GO:0008285:negative regulation of cell population proliferation][GO:0009897:external side of plasma membrane][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005515:protein binding][GO:0009897:external side of plasma membrane][GO:0005886:plasma membrane][GO:0038023:signaling receptor activity][GO:0042127:regulation of cell population proliferation][GO:0005887:integral component of plasma membrane][GO:0038023:signaling receptor activity][GO:0008285:negative regulation of cell population proliferation][GO:0006915:apoptotic process][GO:0019955:cytokine binding] [hsa04060:Cytokine-cytokine receptor interaction] - - - - - - - - - ENSG00000205534 16 29527568 29594966 4221 - SMG1P2 0.083712627 0.226011336 0.151650683 0.401246546 0.328226637 0.70325004 4.856234569 14.73059287 8.444740865 22.36153058 18.65655852 39.14987635 18.03325562 -1.528678167 0.009583855 0.940236002 DOWN - - - - - - - - - - - - ENSG00000243926 3 156671859 156674446 2242 - TIPARP-AS1 0.426687997 0.05142824 0.375750333 1.111508889 1.045618591 0.983553272 7.769975311 1.052185205 6.568131784 19.4448092 18.65655852 17.18775059 11.77990177 -1.829220428 0.009937273 0.945184823 DOWN - - - - - - - - - - - - ENSG00000002587 4 11393150 11429564 8147 - HS3ST1 0.095050705 0.073320692 0.133925808 0.267412445 0.274030743 0.262920259 9.712469138 8.417481642 13.13626357 26.25049242 27.43611547 25.78162589 18.45574135 -1.340331461 0.01028032 0.955706993 DOWN heparan sulfate-glucosamine 3-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5194] [GO:0008146:sulfotransferase activity][GO:0016740:transferase activity][GO:0005794:Golgi apparatus][GO:1901564:organonitrogen compound metabolic process][GO:0005796:Golgi lumen][GO:1901135:carbohydrate derivative metabolic process][GO:0008146:sulfotransferase activity][GO:0005796:Golgi lumen][GO:0008467:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity][GO:0008467:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity][GO:0008467:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity][GO:0006024:glycosaminoglycan biosynthetic process][GO:0008146:sulfotransferase activity][GO:0008146:sulfotransferase activity] [hsa00534:Glycosaminoglycan biosynthesis - heparan sulfate / heparin] - - - - - - - - - ENSG00000248668 5 41869927 41872241 4425 + OXCT1-AS1 0 0 0 0.099644741 0.257319441 0.097970838 0 0 0 2.916721379 7.682112331 2.864625099 2.243909802 -4.622084873 0.011171602 0.962213317 DOWN - - - - - - - - - - - - ENSG00000232527 1 144227029 144250326 1480 - LINC02802 0.965879719 2.638772448 0.567049192 0.167739098 0.649746243 0.247381945 11.65496297 35.77429698 6.568131784 1.94448092 7.682112331 2.864625099 11.08143501 2.126751886 0.011451058 0.972319759 UP - - - - - - - - - - - - ENSG00000224080 3 37143512 37143958 447 - UBE2FP1 4.268669764 5.030648303 3.182289492 1.647370557 1.823193358 1.781666535 26.22366667 34.72211177 18.76609081 9.722404598 10.97444619 10.50362536 18.4853909 1.350990955 0.011737846 0.980332751 UP - - - - - - - - - - - - ENSG00000169231 1 155195588 155209051 19348 - THBS3 0.091719921 0.073699349 0.092309111 0.238927527 0.193913946 0.454166781 5.827481483 5.260926026 5.629827243 14.5836069 12.07189081 27.69137595 11.84418473 -1.704542001 0.013036971 0.985614865 DOWN thrombospondin 3 [Source:HGNC Symbol;Acc:HGNC:11787] [GO:0005576:extracellular region][GO:0005509:calcium ion binding][GO:0007155:cell adhesion][GO:0008201:heparin binding][GO:0005509:calcium ion binding][GO:0005515:protein binding][GO:0048471:perinuclear region of cytoplasm][GO:0005576:extracellular region][GO:0062023:collagen-containing extracellular matrix][GO:0005201:extracellular matrix structural constituent][GO:0062023:collagen-containing extracellular matrix][GO:0007160:cell-matrix adhesion][GO:0008201:heparin binding][GO:0003417:growth plate cartilage development][GO:0043931:ossification involved in bone maturation][GO:0060346:bone trabecula formation][GO:0005576:extracellular region][GO:0005509:calcium ion binding][GO:0007155:cell adhesion][GO:0008201:heparin binding][GO:0005576:extracellular region][GO:0005509:calcium ion binding][GO:0007155:cell adhesion][GO:0008201:heparin binding][GO:0005509:calcium ion binding][GO:0005515:protein binding][GO:0048471:perinuclear region of cytoplasm][GO:0005576:extracellular region][GO:0062023:collagen-containing extracellular matrix][GO:0005201:extracellular matrix structural constituent][GO:0062023:collagen-containing extracellular matrix][GO:0007160:cell-matrix adhesion][GO:0008201:heparin binding][GO:0005576:extracellular region][GO:0005509:calcium ion binding][GO:0007155:cell adhesion][GO:0008201:heparin binding][GO:0005509:calcium ion binding][GO:0005576:extracellular region][GO:0008201:heparin binding] [hsa04145:Phagosome][hsa04151:PI3K-Akt signaling pathway][hsa04510:Focal adhesion][hsa04512:ECM-receptor interaction][hsa05144:Malaria] - - - - - - - - - ENSG00000197614 12 8637346 8662888 13580 - MFAP5 0.109030907 0.070087342 0.146308398 0 0 0.018616726 5.827481483 4.208740821 7.506436324 0 0 0.954875033 3.082922277 4.022387793 0.013410187 0.985614865 UP microfibril associated protein 5 [Source:HGNC Symbol;Acc:HGNC:29673] [GO:0001527:microfibril][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0062023:collagen-containing extracellular matrix][GO:0005201:extracellular matrix structural constituent][GO:0005201:extracellular matrix structural constituent][GO:0060216:definitive hemopoiesis][GO:0048048:embryonic eye morphogenesis][GO:0001527:microfibril][GO:0060216:definitive hemopoiesis][GO:0097435:supramolecular fiber organization][GO:0031012:extracellular matrix][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0062023:collagen-containing extracellular matrix][GO:0005201:extracellular matrix structural constituent][GO:0005201:extracellular matrix structural constituent][GO:0060216:definitive hemopoiesis][GO:0048048:embryonic eye morphogenesis][GO:0001527:microfibril][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0005576:extracellular region][GO:0005576:extracellular region][GO:0001527:microfibril][GO:0062023:collagen-containing extracellular matrix][GO:0005201:extracellular matrix structural constituent][GO:0005201:extracellular matrix structural constituent][GO:0060216:definitive hemopoiesis][GO:0048048:embryonic eye morphogenesis][GO:0001527:microfibril] - - - - - - - - - - ENSG00000275496 21 6228966 6267317 7807 - - 0.540216952 0.662956116 0.939096062 0.307035986 0.226537159 0.402504235 21.3674321 29.46118575 35.65557254 11.66688552 8.77955695 15.27800053 20.36810556 1.269208947 0.013593612 0.985614865 UP - - - - - - - - - - - - ENSG00000243742 11 61615036 61639449 6821 + RPLP0P2 0.054236531 0 0.145559826 0.282568933 0.3752728 0.203736235 2.913740741 0 7.506436324 14.5836069 19.75400314 10.50362536 9.21023541 -2.077167391 0.01607258 0.985614865 DOWN - - - - - - - - - - - - ENSG00000124232 20 45306840 45317824 8124 + RBPJL 0 0 0 0.159273534 0.088136348 0.078298972 0 0 0 5.833442759 3.292333856 2.864625099 1.998400286 -4.462956842 0.016732597 0.985614865 DOWN recombination signal binding protein for immunoglobulin kappa J region like [Source:HGNC Symbol;Acc:HGNC:13761] "[GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005634:nucleus][GO:0003700:DNA-binding transcription factor activity][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0005515:protein binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0007165:signal transduction][GO:0003700:DNA-binding transcription factor activity][GO:0000977:RNA polymerase II regulatory region sequence-specific DNA binding][GO:0003682:chromatin binding][GO:0045893:positive regulation of transcription, DNA-templated][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0005667:transcription factor complex][GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005634:nucleus][GO:0003700:DNA-binding transcription factor activity][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005634:nucleus][GO:0003700:DNA-binding transcription factor activity][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0005515:protein binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:0007165:signal transduction][GO:0003700:DNA-binding transcription factor activity][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0001228:DNA-binding transcription activator activity, RNA polymerase II-specific][GO:0006355:regulation of transcription, DNA-templated][GO:0045944:positive regulation of transcription by RNA polymerase II]" [hsa04330:Notch signaling pathway][hsa04658:Th1 and Th2 cell differentiation][hsa05169:Epstein-Barr virus infection][hsa05203:Viral carcinogenesis] - - - - Other/DNA-binding LAG-1-like Domain Family 16354684 DNA Binding; TF PPI Human; Mouse; Other Medium ENSG00000164270 5 148451032 148677235 23585 - HTR4 0 0 0.010095695 0.041809774 0.034704078 0.102768558 0 0 0.938304541 3.888961839 3.292333856 9.548750329 2.944725094 -3.985447726 0.016885476 0.985614865 DOWN 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] "[GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0005887:integral component of plasma membrane][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0007268:chemical synaptic transmission][GO:0005886:plasma membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0098664:G protein-coupled serotonin receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0005887:integral component of plasma membrane][GO:0007165:signal transduction][GO:0045202:synapse][GO:0007268:chemical synaptic transmission][GO:0004993:G protein-coupled serotonin receptor activity][GO:0098664:G protein-coupled serotonin receptor signaling pathway][GO:0032098:regulation of appetite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0098664:G protein-coupled serotonin receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0004993:G protein-coupled serotonin receptor activity][GO:0005887:integral component of plasma membrane][GO:0007268:chemical synaptic transmission][GO:0032098:regulation of appetite][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005768:endosome][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0045202:synapse][GO:0005886:plasma membrane][GO:0005887:integral component of plasma membrane][GO:0030594:neurotransmitter receptor activity][GO:0007268:chemical synaptic transmission][GO:0030425:dendrite][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0004993:G protein-coupled serotonin receptor activity][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger][GO:0004993:G protein-coupled serotonin receptor activity][GO:0051378:serotonin binding][GO:0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway][GO:0004993:G protein-coupled serotonin receptor activity]" [hsa04020:Calcium signaling pathway][hsa04024:cAMP signaling pathway][hsa04080:Neuroactive ligand-receptor interaction][hsa04726:Serotonergic synapse] - - - - - - - - - ENSG00000235363 1 205351247 205351471 225 + SNRPGP10 1.884538651 1.211420763 3.793289074 12.76382708 2.53545423 7.400934807 5.827481483 4.208740821 11.25965449 37.91737793 7.682112331 21.96212576 14.80958214 -1.662510104 0.017149119 0.985614865 DOWN - - - - - - - - - - - - ENSG00000145934 5 167284799 168264157 29251 + TENM2 0.204804056 0.17279367 0.154589756 0.10003278 0.073806143 0.072125063 31.07990124 29.46118575 22.51930897 14.5836069 10.97444619 10.50362536 19.85367907 1.200851126 0.017549843 0.985614865 UP teneurin transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:29943] [GO:0016021:integral component of membrane][GO:0007165:signal transduction][GO:0005509:calcium ion binding][GO:0005887:integral component of plasma membrane][GO:0005634:nucleus][GO:0005634:nucleus][GO:0016020:membrane][GO:0005783:endoplasmic reticulum][GO:0005783:endoplasmic reticulum][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0007155:cell adhesion][GO:0030054:cell junction][GO:0030054:cell junction][GO:0030175:filopodium][GO:0030175:filopodium][GO:0042995:cell projection][GO:0042803:protein homodimerization activity][GO:0030425:dendrite][GO:0045202:synapse][GO:0045202:synapse][GO:0043005:neuron projection][GO:0043005:neuron projection][GO:0000122:negative regulation of transcription by RNA polymerase II][GO:0045211:postsynaptic membrane][GO:0045211:postsynaptic membrane][GO:0016605:PML body][GO:0016605:PML body][GO:0098609:cell-cell adhesion][GO:0030426:growth cone][GO:0030426:growth cone][GO:0043197:dendritic spine][GO:0043197:dendritic spine][GO:0043005:neuron projection][GO:0042803:protein homodimerization activity][GO:0046982:protein heterodimerization activity][GO:0051491:positive regulation of filopodium assembly][GO:0050839:cell adhesion molecule binding][GO:0007157:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules][GO:0046982:protein heterodimerization activity][GO:0048666:neuron development][GO:0016021:integral component of membrane][GO:0007165:signal transduction][GO:0005509:calcium ion binding][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0042995:cell projection][GO:0016021:integral component of membrane][GO:0007165:signal transduction][GO:0005509:calcium ion binding][GO:0005887:integral component of plasma membrane][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0042995:cell projection] - - - - - - - - - - ENSG00000261526 19 1874871 1876169 1299 - - 0.054403541 0.104915193 0.109506036 0.510190281 0.564642562 0.50161974 0.971246914 2.10437041 1.876609081 8.750164138 9.877001569 8.593875296 5.362211235 -2.462227175 0.01788768 0.985614865 DOWN - - - - - - - - - - - - ENSG00000165874 10 46610474 46652025 4166 - SHLD2P1 0.18835341 0.090808126 0.132694347 0.255140467 0.564742889 0.405226395 9.712469138 5.260926026 6.568131784 12.63912598 28.53356009 20.05237569 13.79443145 -1.498617891 0.018485924 0.985614865 DOWN - - - - - - - - - - - - ENSG00000196436 16 74376306 74392115 4315 + NPIPB15 0 0.122646541 0.025602653 0.265073664 0.205355364 0.416993228 0 5.260926026 0.938304541 9.722404598 7.682112331 15.27800053 6.480291337 -2.436315015 0.019196997 0.985614865 DOWN nuclear pore complex interacting protein family member B15 [Source:HGNC Symbol;Acc:HGNC:34409] [GO:0005654:nucleoplasm][GO:0005576:extracellular region][GO:0005654:nucleoplasm] - - - - - - - - - - ENSG00000164100 4 118033618 118258634 7990 + NDST3 0.061864779 0.059651956 0.041508124 0 0.011890391 0 5.827481483 6.313111231 3.753218162 0 1.097444619 0 2.831875916 3.875219933 0.019443255 0.985614865 UP N-deacetylase and N-sulfotransferase 3 [Source:HGNC Symbol;Acc:HGNC:7682] "[GO:0016787:hydrolase activity][GO:0008146:sulfotransferase activity][GO:0015016:[heparan sulfate]-glucosamine N-sulfotransferase activity][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0016740:transferase activity][GO:0005794:Golgi apparatus][GO:0000139:Golgi membrane][GO:0003824:catalytic activity][GO:0008152:metabolic process][GO:0015012:heparan sulfate proteoglycan biosynthetic process][GO:0015012:heparan sulfate proteoglycan biosynthetic process][GO:0005794:Golgi apparatus][GO:0005575:cellular_component][GO:0019213:deacetylase activity][GO:0015016:[heparan sulfate]-glucosamine N-sulfotransferase activity][GO:0030210:heparin biosynthetic process][GO:0015016:[heparan sulfate]-glucosamine N-sulfotransferase activity][GO:0102140:heparan sulfate N-deacetylase activity][GO:0015014:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process][GO:0015014:heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process]" [hsa00534:Glycosaminoglycan biosynthesis - heparan sulfate / heparin] - - - - - - - - - ENSG00000120279 6 152697897 152724569 6143 + MYCT1 0.023323498 0.022489247 0 0.21872514 0.161379689 0.119472688 0.971246914 1.052185205 0 8.750164138 6.584667713 4.774375164 3.688773189 -3.339387054 0.019759122 0.985614865 DOWN MYC target 1 [Source:HGNC Symbol;Acc:HGNC:23172] [GO:0005634:nucleus][GO:0043231:intracellular membrane-bounded organelle][GO:0005654:nucleoplasm][GO:0005654:nucleoplasm][GO:0061484:hematopoietic stem cell homeostasis][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0043231:intracellular membrane-bounded organelle][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0016021:integral component of membrane] - - - - - - - - - - ENSG00000285669 8 30192429 30201332 4587 + - 0.046219882 0.089133313 0.108539174 0.016053513 0 0 2.913740741 6.313111231 6.568131784 0.97224046 0 0 2.794537369 3.867707541 0.020761721 0.985614865 UP - - - - - - - - - - - - ENSG00000279673 3 171460612 171462256 1645 + - 0.257763645 0.165695849 0.648548664 1.074345978 0.792673489 1.144323209 5.827481483 4.208740821 14.07456811 23.33377104 17.5591139 24.82675085 14.9717377 -1.437304762 0.020859571 0.985614865 DOWN - - - - - - - - - - - - ENSG00000253540 3 130097782 130111506 35237 - FAM86HP 0.143901852 0.152630136 0.159308872 0.389854217 0.497842047 0.265365116 9.712469138 11.57403726 10.32134995 25.27825196 32.92333856 17.18775059 17.83286624 -1.251151555 0.021244658 0.985614865 DOWN - - - - - - - - - - - - ENSG00000270060 11 47168281 47169563 574 - - 0.123118814 0.593575069 0.743458224 0 0 0 0.971246914 5.260926026 5.629827243 0 0 0 1.97700003 4.416160955 0.021431694 0.985614865 UP - - - - - - - - - - - - ENSG00000282393 19 248551 251571 3021 - - 0.116964911 0.067668737 0.188346031 0.024375195 0 0 4.856234569 3.156555616 7.506436324 0.97224046 0 0 2.748577828 3.846738097 0.021976022 0.985614865 UP - - - - - - - - - - - - ENSG00000235609 21 14818843 15014430 5929 - - 0.107274717 0.103437639 0.239919616 0.397436135 0.357381569 0.317492272 8.741222224 9.469666847 18.76609081 31.11169471 28.53356009 24.82675085 20.24149759 -1.184992989 0.022238212 0.985614865 DOWN - - - - - - - - - - - - ENSG00000106125 7 30771417 30892387 8794 + MINDY4 0.009633342 0.037155081 0.067866575 0 0 0 0.971246914 4.208740821 6.568131784 0 0 0 1.95801992 4.404215826 0.022419663 0.985614865 UP MINDY lysine 48 deubiquitinase 4 [Source:HGNC Symbol;Acc:HGNC:21916] [GO:0004843:thiol-dependent ubiquitin-specific protease activity][GO:1990380:Lys48-specific deubiquitinase activity][GO:0071108:protein K48-linked deubiquitination][GO:0008233:peptidase activity][GO:0008234:cysteine-type peptidase activity][GO:0006508:proteolysis][GO:0016787:hydrolase activity][GO:1990380:Lys48-specific deubiquitinase activity] - - - - - - - - - - ENSG00000259523 15 29822631 29824081 1451 + - 0.048704479 0.093924766 0.049017347 0.405995666 0.336995492 0.498969326 0.971246914 2.10437041 0.938304541 7.777923679 6.584667713 9.548750329 4.654210597 -2.593300041 0.02246998 0.985614865 DOWN - - - - - - - - - - - - ENSG00000177076 9 19409009 19452505 2773 + ACER2 0.458731911 0.466897202 0.589922796 0.265551619 0.088168132 0.234981624 17.48244445 19.9915189 21.58100443 9.722404598 3.292333856 8.593875296 13.44393025 1.43675404 0.022804173 0.985614865 UP alkaline ceramidase 2 [Source:HGNC Symbol;Acc:HGNC:23675] "[GO:0016021:integral component of membrane][GO:0016811:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides][GO:0006672:ceramide metabolic process][GO:0016020:membrane][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0005794:Golgi apparatus][GO:0016787:hydrolase activity][GO:0006629:lipid metabolic process][GO:0006665:sphingolipid metabolic process][GO:0000139:Golgi membrane][GO:0006974:cellular response to DNA damage stimulus][GO:0008284:positive regulation of cell population proliferation][GO:0042981:regulation of apoptotic process][GO:0017040:N-acylsphingosine amidohydrolase activity][GO:0017040:N-acylsphingosine amidohydrolase activity][GO:0102121:ceramidase activity][GO:0030173:integral component of Golgi membrane][GO:0046512:sphingosine biosynthetic process][GO:0046512:sphingosine biosynthetic process][GO:0000139:Golgi membrane][GO:0010506:regulation of autophagy][GO:0030148:sphingolipid biosynthetic process][GO:0001953:negative regulation of cell-matrix adhesion][GO:0030330:DNA damage response, signal transduction by p53 class mediator][GO:0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process][GO:0032526:response to retinoic acid][GO:0010942:positive regulation of cell death][GO:0033629:negative regulation of cell adhesion mediated by integrin][GO:0071466:cellular response to xenobiotic stimulus][GO:0046514:ceramide catabolic process][GO:0017040:N-acylsphingosine amidohydrolase activity][GO:0071633:dihydroceramidase activity][GO:0071633:dihydroceramidase activity][GO:0071633:dihydroceramidase activity][GO:0046512:sphingosine biosynthetic process][GO:0090285:negative regulation of protein glycosylation in Golgi]" [hsa00600:Sphingolipid metabolism][hsa04071:Sphingolipid signaling pathway] - - - - - - - - - ENSG00000258568 14 49599994 49600572 579 + RHOQP1 0.122055612 1.647657774 0.245679344 0 0 0.125043954 0.971246914 14.73059287 1.876609081 0 0 0.954875033 3.088887317 4.013781966 0.023369441 0.985614865 UP - - - - - - - - - - - - ENSG00000244560 7 149285281 149297312 9781 + - 0 0 0.016586793 0.051518748 0.095028852 0.118191032 0 0 0.938304541 2.916721379 5.487223094 6.68412523 2.671062374 -3.830997288 0.023435265 0.985614865 DOWN - - - - - - - - - - - - ENSG00000251194 11 35212550 35214007 704 + - 0.100383806 0.096793207 0.303085952 0.836789363 0.810336934 1.131257019 0.971246914 1.052185205 2.814913622 7.777923679 7.682112331 10.50362536 5.133667852 -2.411054686 0.023896992 0.985614865 DOWN - - - - - - - - - - - - ENSG00000261499 17 36274191 36320547 1168 + - 0.847074308 0.350046667 0.182681944 1.197869704 1.465266785 1.363707091 13.59745679 6.313111231 2.814913622 18.47256874 23.04633699 21.00725072 14.20860635 -1.46047995 0.024101504 0.985614865 DOWN - - - - - - - - - - - - ENSG00000224418 13 98577244 98578830 1278 + STK24-AS1 0 0 0 0.288096494 0.318844848 0.056651369 0 0 0 4.861202299 5.487223094 0.954875033 1.883883404 -4.371771485 0.024677637 0.985614865 DOWN - - - - - - - - - - - - ENSG00000228933 X 27174920 27399006 9167 - - 0 0.060019746 0.07308708 0 0 0 0 6.313111231 6.568131784 0 0 0 2.146873836 4.534827399 0.024680586 0.985614865 UP - - - - - - - - - - - - ENSG00000254275 8 128405269 128564679 5841 - LINC00824 0 0 0.015607674 0.129273582 0.053651575 0.063550976 0 0 0.938304541 7.777923679 3.292333856 3.819500132 2.638010368 -3.815436921 0.024821638 0.985614865 DOWN - - - - - - - - - - - - ENSG00000203896 20 63736283 63739103 8742 + LIME1 0.22171043 0.160335101 0.334701977 0.404284116 0.703109156 0.794985325 7.769975311 6.313111231 11.25965449 13.61136644 24.14378161 26.73650092 14.97239833 -1.340462373 0.025845153 0.985614865 DOWN Lck interacting transmembrane adaptor 1 [Source:HGNC Symbol;Acc:HGNC:26016] [GO:0050852:T cell receptor signaling pathway][GO:0050853:B cell receptor signaling pathway][GO:0050852:T cell receptor signaling pathway][GO:0050853:B cell receptor signaling pathway][GO:0050852:T cell receptor signaling pathway][GO:0050853:B cell receptor signaling pathway][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005886:plasma membrane][GO:0005615:extracellular space][GO:0005515:protein binding][GO:0002376:immune system process][GO:0002250:adaptive immune response][GO:0050853:B cell receptor signaling pathway][GO:0019901:protein kinase binding][GO:0006357:regulation of transcription by RNA polymerase II][GO:0014066:regulation of phosphatidylinositol 3-kinase signaling][GO:0043122:regulation of I-kappaB kinase/NF-kappaB signaling][GO:0043405:regulation of MAP kinase activity][GO:0051279:regulation of release of sequestered calcium ion into cytosol][GO:1901222:regulation of NIK/NF-kappaB signaling][GO:0019815:B cell receptor complex][GO:0050852:T cell receptor signaling pathway][GO:0050853:B cell receptor signaling pathway][GO:0050852:T cell receptor signaling pathway][GO:0050853:B cell receptor signaling pathway][GO:0050852:T cell receptor signaling pathway][GO:0050853:B cell receptor signaling pathway][GO:0016020:membrane][GO:0016021:integral component of membrane] - - - - - - - - - - ENSG00000125122 16 67207139 67227048 12521 - LRRC29 0.100705664 0.024275888 0 0.104934042 0.203233773 0.464270782 3.884987655 1.052185205 0 3.888961839 7.682112331 17.18775059 5.615999604 -2.546384015 0.026093791 0.985614865 DOWN - - - - - - - - - - - - ENSG00000236136 1 209744373 209745214 842 + ADORA2BP1 0.25179406 0.161858475 0.253411533 0.787098783 0.967894811 1.031835381 2.913740741 2.10437041 2.814913622 8.750164138 10.97444619 11.45850039 6.502689249 -1.988034074 0.027063774 0.985614865 DOWN - - - - - - - - - - - - ENSG00000204915 X 45730752 45731688 937 + MFFP3 0.301687084 0.218172096 0.607250119 0.078588542 0 0 3.884987655 3.156555616 7.506436324 0.97224046 0 0 2.586703342 3.75350441 0.027835507 0.985614865 UP - - - - - - - - - - - - ENSG00000272894 7 7552462 7566996 2020 - MIOS-DT 0 0 0 0.042565008 0.423971496 0.041849971 0 0 0 0.97224046 9.877001569 0.954875033 1.967352844 -4.426984113 0.027893061 0.985614865 DOWN - - - - - - - - - - - - ENSG00000139438 12 109713825 109770495 6873 + FAM222A 0.360825234 0.662702824 0.363143101 0.250650254 0.257587566 0.140822658 20.39618519 42.08740821 19.70439535 13.61136644 14.26678004 7.639000263 19.61752258 1.210950171 0.028212663 0.985614865 UP family with sequence similarity 222 member A [Source:HGNC Symbol;Acc:HGNC:25915] - - - - - - - - - - - ENSG00000149090 11 35431823 35530300 15616 - PAMR1 0.1098216 0.088244519 0.184211785 0.209793344 0.485476584 0.393786437 5.827481483 5.260926026 9.383045405 10.69464506 25.24122623 20.05237569 12.74328332 -1.441397531 0.028816857 0.985614865 DOWN peptidase domain containing associated with muscle regeneration 1 [Source:HGNC Symbol;Acc:HGNC:24554] [GO:0006508:proteolysis][GO:0005509:calcium ion binding][GO:0004252:serine-type endopeptidase activity][GO:0005576:extracellular region][GO:0006508:proteolysis][GO:0005509:calcium ion binding][GO:0004252:serine-type endopeptidase activity][GO:0005576:extracellular region][GO:0006508:proteolysis][GO:0005509:calcium ion binding][GO:0004252:serine-type endopeptidase activity][GO:0006955:immune response][GO:0002252:immune effector process][GO:0006508:proteolysis][GO:0005509:calcium ion binding][GO:0004252:serine-type endopeptidase activity][GO:0006955:immune response][GO:0002252:immune effector process][GO:0005509:calcium ion binding][GO:0006508:proteolysis][GO:0005509:calcium ion binding][GO:0004252:serine-type endopeptidase activity][GO:0005576:extracellular region] - - - - - - - - - - ENSG00000260260 16 2154792 2155405 3742 - SNHG19 5.17941201 0.99883023 1.505886338 6.955981933 5.972888338 4.48080956 43.70611112 9.469666847 12.19795903 56.38994667 49.38500784 36.28525125 34.57232379 -1.115832401 0.029287124 0.985614865 DOWN - - - - - - - - - - - - ENSG00000223839 9 40321299 40329221 19033 + FAM95B1 0.017839253 0.008600583 0 0.037176556 0.133719255 0.036552038 1.942493828 1.052185205 0 3.888961839 14.26678004 3.819500132 4.161653508 -2.876491558 0.030190193 0.985614865 DOWN - - - - - - - - - - - - ENSG00000184227 14 73537143 73543796 2957 + ACOT1 0.544906638 0.20208309 0.464036697 1.179247643 0.966746656 0.858842814 12.62620988 5.260926026 10.32134995 26.25049242 21.94889238 19.09750066 15.91756188 -1.247175971 0.030196918 0.985614865 DOWN acyl-CoA thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:33128] [GO:0006637:acyl-CoA metabolic process][GO:0016790:thiolester hydrolase activity][GO:0005737:cytoplasm][GO:0016787:hydrolase activity][GO:0006629:lipid metabolic process][GO:0006631:fatty acid metabolic process][GO:0005829:cytosol][GO:0052689:carboxylic ester hydrolase activity][GO:0005829:cytosol][GO:0016290:palmitoyl-CoA hydrolase activity][GO:0047617:acyl-CoA hydrolase activity][GO:0102991:myristoyl-CoA hydrolase activity][GO:0006631:fatty acid metabolic process][GO:0006637:acyl-CoA metabolic process][GO:0005829:cytosol][GO:0047617:acyl-CoA hydrolase activity][GO:0000038:very long-chain fatty acid metabolic process][GO:0001676:long-chain fatty acid metabolic process][GO:0006637:acyl-CoA metabolic process][GO:0006637:acyl-CoA metabolic process][GO:0016790:thiolester hydrolase activity][GO:0005737:cytoplasm][GO:0006629:lipid metabolic process][GO:0006631:fatty acid metabolic process][GO:0052689:carboxylic ester hydrolase activity] [hsa00062:Fatty acid elongation][hsa01040:Biosynthesis of unsaturated fatty acids] - - - - - - - - - ENSG00000275180 12 62603909 62604399 491 + - 1.871105076 1.387829286 2.462547642 5.249106389 3.651585231 3.833832341 12.62620988 10.52185205 15.95117719 34.02841609 24.14378161 24.82675085 20.34969795 -1.083251169 0.030230647 0.985614865 DOWN - - - - - - - - - - - - ENSG00000230285 1 85599131 85600734 255 + - 0.831414111 0.267225168 0 1.443871841 4.793926065 1.135693321 2.913740741 1.052185205 0 4.861202299 16.46166928 3.819500132 4.851382943 -2.659415976 0.030523952 0.985614865 DOWN - - - - - - - - - - - - ENSG00000146233 6 46549580 46652830 5887 - CYP39A1 0.045432465 0 0.022862157 0.02367003 0.28815949 0.232724041 1.942493828 0 0.938304541 0.97224046 12.07189081 9.548750329 4.245613327 -2.944998006 0.031199005 0.985614865 DOWN cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] "[GO:0004497:monooxygenase activity][GO:0020037:heme binding][GO:0005506:iron ion binding][GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0046872:metal ion binding][GO:0005783:endoplasmic reticulum][GO:0005789:endoplasmic reticulum membrane][GO:0016491:oxidoreductase activity][GO:0043231:intracellular membrane-bounded organelle][GO:0043231:intracellular membrane-bounded organelle][GO:0006629:lipid metabolic process][GO:0008202:steroid metabolic process][GO:0008203:cholesterol metabolic process][GO:0007586:digestion][GO:0008395:steroid hydroxylase activity][GO:0005789:endoplasmic reticulum membrane][GO:0006699:bile acid biosynthetic process][GO:0006699:bile acid biosynthetic process][GO:0006699:bile acid biosynthetic process][GO:0006699:bile acid biosynthetic process][GO:0042632:cholesterol homeostasis][GO:0008396:oxysterol 7-alpha-hydroxylase activity][GO:0008396:oxysterol 7-alpha-hydroxylase activity][GO:0008396:oxysterol 7-alpha-hydroxylase activity][GO:0033782:24-hydroxycholesterol 7alpha-hydroxylase activity][GO:0016125:sterol metabolic process][GO:0006707:cholesterol catabolic process][GO:0008387:steroid 7-alpha-hydroxylase activity][GO:0008387:steroid 7-alpha-hydroxylase activity][GO:0008396:oxysterol 7-alpha-hydroxylase activity][GO:0004497:monooxygenase activity][GO:0020037:heme binding][GO:0005506:iron ion binding][GO:0016705:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]" [hsa00120:Primary bile acid biosynthesis] - - - - - - - - - ENSG00000228960 7 144294480 144300934 7865 + OR2A9P 0 0 0 0.088267862 0.097688634 0.043392538 0 0 0 3.888961839 4.389778475 1.909750066 1.69808173 -4.223518361 0.031303858 0.985614865 DOWN - - - - - - - - - - - - ENSG00000263745 18 1883524 2489426 11379 - - 0.031852554 0.061426458 0.021371445 0.099569888 0.208149734 0.119652185 2.913740741 6.313111231 1.876609081 8.750164138 18.65655852 10.50362536 8.168968179 -1.781799782 0.032967546 0.985614865 DOWN - - - - - - - - - - - - ENSG00000259668 15 51455268 51460582 5285 + - 0.064617677 0.186919159 0.130065535 0 0.024838995 0.02206658 2.913740741 9.469666847 5.629827243 0 1.097444619 0.954875033 3.344259081 3.150458058 0.033939041 0.985614865 UP - - - - - - - - - - - - ENSG00000165985 10 16513734 16521879 3159 - C1QL3 0.624610348 1.061140346 0.927966866 0.588851774 0.308699784 0.426601973 20.39618519 38.93085259 29.08744076 18.47256874 9.877001569 13.36825046 21.68871655 1.075181265 0.03400277 0.985614865 UP complement C1q like 3 [Source:HGNC Symbol;Acc:HGNC:19359] [GO:0005515:protein binding][GO:0005576:extracellular region][GO:0005581:collagen trimer][GO:0042802:identical protein binding][GO:0050807:regulation of synapse organization][GO:0005515:protein binding][GO:0005576:extracellular region][GO:0005581:collagen trimer] - - - - - - - - - - ENSG00000115286 19 1383527 1395589 30762 + NDUFS7 0.018956599 0.027417818 0.038156744 0.088886424 0.098373215 0.135945049 1.942493828 3.156555616 3.753218162 8.750164138 9.877001569 13.36825046 6.807947295 -1.85425079 0.034610844 0.985614865 DOWN NADH:ubiquinone oxidoreductase core subunit S7 [Source:HGNC Symbol;Acc:HGNC:7714] "[GO:0048038:quinone binding][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0051539:4 iron, 4 sulfur cluster binding][GO:0051536:iron-sulfur cluster binding][GO:0016020:membrane][GO:0046872:metal ion binding][GO:0016491:oxidoreductase activity][GO:0005739:mitochondrion][GO:0005743:mitochondrial inner membrane][GO:0005515:protein binding][GO:0070469:respirasome][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0032981:mitochondrial respiratory chain complex I assembly][GO:0032981:mitochondrial respiratory chain complex I assembly][GO:0005759:mitochondrial matrix][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0003954:NADH dehydrogenase activity][GO:0006120:mitochondrial electron transport, NADH to ubiquinone][GO:0006120:mitochondrial electron transport, NADH to ubiquinone][GO:0009060:aerobic respiration][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor][GO:0015990:electron transport coupled proton transport][GO:0048038:quinone binding][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0051539:4 iron, 4 sulfur cluster binding][GO:0051536:iron-sulfur cluster binding][GO:0046872:metal ion binding][GO:0016491:oxidoreductase activity][GO:0005743:mitochondrial inner membrane][GO:0070469:respirasome][GO:0022900:electron transport chain][GO:0048038:quinone binding][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0051539:4 iron, 4 sulfur cluster binding][GO:0051536:iron-sulfur cluster binding][GO:0016020:membrane][GO:0046872:metal ion binding][GO:0016491:oxidoreductase activity][GO:0005739:mitochondrion][GO:0005743:mitochondrial inner membrane][GO:0005515:protein binding][GO:0070469:respirasome][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0032981:mitochondrial respiratory chain complex I assembly][GO:0032981:mitochondrial respiratory chain complex I assembly][GO:0005759:mitochondrial matrix][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0003954:NADH dehydrogenase activity][GO:0006120:mitochondrial electron transport, NADH to ubiquinone][GO:0006120:mitochondrial electron transport, NADH to ubiquinone][GO:0009060:aerobic respiration][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor][GO:0015990:electron transport coupled proton transport][GO:0048038:quinone binding][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0051539:4 iron, 4 sulfur cluster binding][GO:0051536:iron-sulfur cluster binding][GO:0016020:membrane][GO:0046872:metal ion binding][GO:0016491:oxidoreductase activity][GO:0005739:mitochondrion][GO:0005743:mitochondrial inner membrane][GO:0005515:protein binding][GO:0070469:respirasome][GO:0022900:electron transport chain][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0032981:mitochondrial respiratory chain complex I assembly][GO:0032981:mitochondrial respiratory chain complex I assembly][GO:0005759:mitochondrial matrix][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0005747:mitochondrial respiratory chain complex I][GO:0003954:NADH dehydrogenase activity][GO:0006120:mitochondrial electron transport, NADH to ubiquinone][GO:0006120:mitochondrial electron transport, NADH to ubiquinone][GO:0009060:aerobic respiration][GO:0002020:protease binding][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0016655:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor][GO:0015990:electron transport coupled proton transport][GO:0043005:neuron projection][GO:0043025:neuronal cell body][GO:0097060:synaptic membrane][GO:0048038:quinone binding][GO:0008137:NADH dehydrogenase (ubiquinone) activity][GO:0051539:4 iron, 4 sulfur cluster binding][GO:0051536:iron-sulfur cluster binding][GO:0046872:metal ion binding][GO:0016491:oxidoreductase activity][GO:0005743:mitochondrial inner membrane][GO:0070469:respirasome][GO:0022900:electron transport chain]" [hsa00190:Oxidative phosphorylation][hsa04932:Non-alcoholic fatty liver disease (NAFLD)][hsa05010:Alzheimer's disease][hsa05012:Parkinson's disease][hsa05016:Huntington's disease] - - - - - - - - - ENSG00000267543 17 76549951 76550826 570 + - 0 0.119548102 0 0.645942666 0.714883711 0.381054996 0 1.052185205 0 4.861202299 5.487223094 2.864625099 2.377539283 -3.636876776 0.036034158 0.985614865 DOWN - - - - - - - - - - - - ENSG00000182873 1 2181794 2184389 1875 - PRKCZ-AS1 0.203777968 0.117893457 0.082034798 0 0 0 4.856234569 3.156555616 1.876609081 0 0 0 1.648233211 4.153815261 0.03607338 0.985614865 UP - - - - - - - - - - - - ENSG00000264575 18 5236724 5238598 1875 - LINC00526 0.301526184 0.327083606 0.455194689 1.06037948 0.695438874 0.849498604 7.769975311 9.469666847 11.25965449 26.25049242 17.5591139 21.00725072 15.55269228 -1.186657667 0.036205456 0.985614865 DOWN - - - - - - - - - - - - ENSG00000289592 10 71888523 71889171 649 - - 0.108890908 0 0 0.567314822 0.627863968 0.334670798 0.971246914 0 0 4.861202299 5.487223094 2.864625099 2.364049568 -3.636889627 0.036261504 0.985614865 DOWN - - - - - - - - - - - - ENSG00000227815 1 176272483 176273402 795 + - 0 0 0 0.185251482 0.205023253 0.546418485 0 0 0 1.94448092 2.194889238 5.729250197 1.644770059 -4.184650047 0.036286019 0.985614865 DOWN - - - - - - - - - - - - ENSG00000125910 19 3172346 3180332 1977 + S1PR4 0.25497366 0.122926791 0.384917337 0 0.049005859 0.043536049 5.827481483 3.156555616 8.444740865 0 1.097444619 0.954875033 3.246849602 3.111621338 0.036439319 0.985614865 UP sphingosine-1-phosphate receptor 4 [Source:HGNC Symbol;Acc:HGNC:3170] [GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0038036:sphingosine-1-phosphate receptor activity][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005739:mitochondrion][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0005737:cytoplasm][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0004930:G protein-coupled receptor activity][GO:0003376:sphingosine-1-phosphate receptor signaling pathway][GO:0004930:G protein-coupled receptor activity][GO:0007186:G protein-coupled receptor signaling pathway][GO:0005887:integral component of plasma membrane][GO:0006955:immune response][GO:0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway][GO:0008289:lipid binding][GO:0007204:positive regulation of cytosolic calcium ion concentration][GO:0019222:regulation of metabolic process][GO:0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway][GO:0007202:activation of phospholipase C activity] [hsa04068:FoxO signaling pathway][hsa04071:Sphingolipid signaling pathway][hsa04080:Neuroactive ligand-receptor interaction] - - - - - - - - - ENSG00000163485 1 203090654 203167405 16293 + ADORA1 0.118036601 0.081296132 0.220618996 0.333837226 0.330576147 0.397330072 6.798728397 5.260926026 12.19795903 18.47256874 18.65655852 21.96212576 13.89147774 -1.276699918 0.036698184 0.985614865 DOWN adenosine A1 receptor [Source:HGNC Symbol;Acc:HGNC:262] "[GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0001609:G protein-coupled adenosine receptor activity][GO:0001973:adenosine receptor signaling pathway][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0099509:regulation of presynaptic cytosolic calcium ion concentration][GO:0005886:plasma membrane][GO:0007399:nervous system development][GO:0005887:integral component of plasma membrane][GO:0006954:inflammatory response][GO:0007165:signal transduction][GO:0007267:cell-cell signaling][GO:0097190:apoptotic signaling pathway][GO:0006909:phagocytosis][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0001609:G protein-coupled adenosine receptor activity][GO:0001973:adenosine receptor signaling pathway][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0099509:regulation of presynaptic cytosolic calcium ion concentration][GO:0005886:plasma membrane][GO:0007399:nervous system development][GO:0005887:integral component of plasma membrane][GO:0006954:inflammatory response][GO:0007165:signal transduction][GO:0007267:cell-cell signaling][GO:0097190:apoptotic signaling pathway][GO:0006909:phagocytosis][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0001609:G protein-coupled adenosine receptor activity][GO:0001973:adenosine receptor signaling pathway][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0099509:regulation of presynaptic cytosolic calcium ion concentration][GO:0005886:plasma membrane][GO:0007399:nervous system development][GO:0005887:integral component of plasma membrane][GO:0006954:inflammatory response][GO:0007165:signal transduction][GO:0007267:cell-cell signaling][GO:0097190:apoptotic signaling pathway][GO:0006909:phagocytosis][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0001609:G protein-coupled adenosine receptor activity][GO:0001973:adenosine receptor signaling pathway][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0099509:regulation of presynaptic cytosolic calcium ion concentration][GO:0005886:plasma membrane][GO:0007399:nervous system development][GO:0005887:integral component of plasma membrane][GO:0006954:inflammatory response][GO:0007165:signal transduction][GO:0007267:cell-cell signaling][GO:0097190:apoptotic signaling pathway][GO:0006909:phagocytosis][GO:0001664:G protein-coupled receptor binding][GO:0001883:purine nucleoside binding][GO:0031072:heat shock protein binding][GO:0031683:G-protein beta/gamma-subunit complex binding][GO:0032795:heterotrimeric G-protein binding][GO:0044877:protein-containing complex binding][GO:0046982:protein heterodimerization activity][GO:0099582:neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration][GO:0001659:temperature homeostasis][GO:0001666:response to hypoxia][GO:0002087:regulation of respiratory gaseous exchange by neurological system process][GO:0002674:negative regulation of acute inflammatory response][GO:0002686:negative regulation of leukocyte migration][GO:0002793:positive regulation of peptide secretion][GO:0003084:positive regulation of systemic arterial blood pressure][GO:0003085:negative regulation of systemic arterial blood pressure][GO:0003093:regulation of glomerular filtration][GO:0006612:protein targeting to membrane][GO:0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway][GO:0008285:negative regulation of cell population proliferation][GO:0014050:negative regulation of glutamate secretion][GO:0016042:lipid catabolic process][GO:0032229:negative regulation of synaptic transmission, GABAergic][GO:0032244:positive regulation of nucleoside transport][GO:0032900:negative regulation of neurotrophin production][GO:0035307:positive regulation of protein dephosphorylation][GO:0035814:negative regulation of renal sodium excretion][GO:0042311:vasodilation][GO:0042321:negative regulation of circadian sleep/wake cycle, sleep][GO:0042323:negative regulation of circadian sleep/wake cycle, non-REM sleep][GO:0043066:negative regulation of apoptotic process][GO:0043268:positive regulation of potassium ion transport][GO:0043410:positive regulation of MAPK cascade][GO:0045741:positive regulation of epidermal growth factor-activated receptor activity][GO:0045776:negative regulation of blood pressure][GO:0045777:positive regulation of blood pressure][GO:0045822:negative regulation of heart contraction][GO:0046888:negative regulation of hormone secretion][GO:0050728:negative regulation of inflammatory response][GO:0050890:cognition][GO:0050965:detection of temperature stimulus involved in sensory perception of pain][GO:0050995:negative regulation of lipid catabolic process][GO:0050996:positive regulation of lipid catabolic process][GO:0051930:regulation of sensory perception of pain][GO:0051967:negative regulation of synaptic transmission, glutamatergic][GO:0055089:fatty acid homeostasis][GO:0055117:regulation of cardiac muscle contraction][GO:0060079:excitatory postsynaptic potential][GO:0060087:relaxation of vascular smooth muscle][GO:0070256:negative regulation of mucus secretion][GO:0070328:triglyceride homeostasis][GO:0086004:regulation of cardiac muscle cell contraction][GO:1900272:negative regulation of long-term synaptic potentiation][GO:1900453:negative regulation of long-term synaptic depression][GO:1901216:positive regulation of neuron death][GO:0005783:endoplasmic reticulum][GO:0012505:endomembrane system][GO:0014069:postsynaptic density][GO:0016323:basolateral plasma membrane][GO:0030425:dendrite][GO:0030673:axolemma][GO:0032279:asymmetric synapse][GO:0042734:presynaptic membrane][GO:0043025:neuronal cell body][GO:0043195:terminal bouton][GO:0043197:dendritic spine][GO:0044297:cell body][GO:0044305:calyx of Held][GO:0045202:synapse][GO:0045211:postsynaptic membrane][GO:0048786:presynaptic active zone][GO:0099055:integral component of postsynaptic membrane][GO:0099056:integral component of presynaptic membrane][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0001609:G protein-coupled adenosine receptor activity][GO:0001973:adenosine receptor signaling pathway][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0007165:signal transduction][GO:0005515:protein binding][GO:0099509:regulation of presynaptic cytosolic calcium ion concentration][GO:0005886:plasma membrane][GO:0007399:nervous system development][GO:0005887:integral component of plasma membrane][GO:0006954:inflammatory response][GO:0007165:signal transduction][GO:0007267:cell-cell signaling][GO:0097190:apoptotic signaling pathway][GO:0006909:phagocytosis][GO:0007186:G protein-coupled receptor signaling pathway][GO:0016021:integral component of membrane][GO:0004930:G protein-coupled receptor activity][GO:0001609:G protein-coupled adenosine receptor activity][GO:0001973:adenosine receptor signaling pathway][GO:0016020:membrane][GO:0005886:plasma membrane][GO:0005886:plasma membrane][GO:0007165:signal transduction][GO:0050896:response to stimulus]" [hsa04022:cGMP-PKG signaling pathway][hsa04024:cAMP signaling pathway][hsa04071:Sphingolipid signaling pathway][hsa04080:Neuroactive ligand-receptor interaction][hsa04923:Regulation of lipolysis in adipocytes][hsa04924:Renin secretion][hsa05032:Morphine addiction] - - - - - - - - - ENSG00000227077 17 18572752 18572961 210 + - 0.673049518 0 0 1.40261836 1.552318916 3.447640438 1.942493828 0 0 3.888961839 4.389778475 9.548750329 3.294997412 -3.187849103 0.037115089 0.985614865 DOWN - - - - - - - - - - - - ENSG00000230534 10 35098006 35127020 1741 - - 0.248488746 0.09584025 0.150050992 0 0 0 4.856234569 2.10437041 2.814913622 0 0 0 1.6292531 4.139678348 0.037121659 0.985614865 UP - - - - - - - - - - - - ENSG00000134072 3 9757347 9769992 6460 - CAMK1 0.104118158 0.150590979 0.052393495 0.461081726 0.210120516 0.400002482 3.884987655 6.313111231 1.876609081 16.52808782 7.682112331 14.32312549 8.434672268 -1.692677853 0.037312794 0.985614865 DOWN calcium/calmodulin dependent protein kinase I [Source:HGNC Symbol;Acc:HGNC:1459] [GO:0005524:ATP binding][GO:0006468:protein phosphorylation][GO:0004672:protein kinase activity][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0000166:nucleotide binding][GO:0004674:protein serine/threonine kinase activity][GO:0016301:kinase activity][GO:0016740:transferase activity][GO:0016310:phosphorylation][GO:0030154:cell differentiation][GO:0045944:positive regulation of transcription by RNA polymerase II][GO:0003824:catalytic activity][GO:0008152:metabolic process][GO:0005515:protein binding][GO:0007049:cell cycle][GO:0007399:nervous system development][GO:0006468:protein phosphorylation][GO:0005516:calmodulin binding][GO:0004683:calmodulin-dependent protein kinase activity][GO:0004683:calmodulin-dependent protein kinase activity][GO:0005516:calmodulin binding][GO:0005829:cytosol][GO:0033138:positive regulation of peptidyl-serine phosphorylation][GO:0071902:positive regulation of protein serine/threonine kinase activity][GO:0032880:regulation of protein localization][GO:0006913:nucleocytoplasmic transport][GO:0007165:signal transduction][GO:0046827:positive regulation of protein export from nucleus][GO:0050807:regulation of synapse organization][GO:0014069:postsynaptic density][GO:0098978:glutamatergic synapse][GO:0018105:peptidyl-serine phosphorylation][GO:0006468:protein phosphorylation][GO:0007165:signal transduction][GO:1901985:positive regulation of protein acetylation][GO:0032091:negative regulation of protein binding][GO:0010976:positive regulation of neuron projection development][GO:0051147:regulation of muscle cell differentiation][GO:0060999:positive regulation of dendritic spine development][GO:0046827:positive regulation of protein export from nucleus][GO:0060143:positive regulation of syncytium formation by plasma membrane fusion][GO:0051149:positive regulation of muscle cell differentiation][GO:0004683:calmodulin-dependent protein kinase activity][GO:0043393:regulation of protein binding][GO:0051835:positive regulation of synapse structural plasticity][GO:0005524:ATP binding][GO:0006468:protein phosphorylation][GO:0004672:protein kinase activity][GO:0005524:ATP binding][GO:0006468:protein phosphorylation][GO:0004672:protein kinase activity] [hsa04921:Oxytocin signaling pathway][hsa04925:Aldosterone synthesis and secretion] - - - - - - - - - ENSG00000279800 16 34266041 34268649 2609 - BCLAF1P2 0.487567493 0.940255671 0.627004949 0.310468418 0.343604513 0.360753484 17.48244445 37.87866739 21.58100443 10.69464506 12.07189081 12.41337543 18.68700459 1.125107133 0.037794385 0.985614865 UP - - - - - - - - - - - - ENSG00000267221 17 42038232 42050601 3733 - C17orf113 0.075724832 0.073016253 0.019052818 0.335343393 0.174651472 0.155157673 3.884987655 4.208740821 0.938304541 16.52808782 8.77955695 7.639000263 6.996446341 -1.881271704 0.037959917 0.985614865 DOWN chromosome 17 open reading frame 113 [Source:HGNC Symbol;Acc:HGNC:53437] [GO:0016020:membrane][GO:0016021:integral component of membrane] - - - - - - - - - - ENSG00000162300 11 65084210 65088398 12173 + ZFPL1 0.113253525 0.065521556 0.227962084 0.306822766 0.574656522 0.301668538 4.856234569 3.156555616 9.383045405 12.63912598 24.14378161 12.41337543 11.09868643 -1.482829212 0.038030831 0.985614865 DOWN zinc finger protein like 1 [Source:HGNC Symbol;Acc:HGNC:12868] "[GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0016192:vesicle-mediated transport][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0016192:vesicle-mediated transport][GO:0005634:nucleus][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005794:Golgi apparatus][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0008270:zinc ion binding][GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0016192:vesicle-mediated transport][GO:0005515:protein binding][GO:0005794:Golgi apparatus][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005794:Golgi apparatus][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0016192:vesicle-mediated transport][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005794:Golgi apparatus][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0016192:vesicle-mediated transport][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005794:Golgi apparatus][GO:0046872:metal ion binding][GO:0005794:Golgi apparatus][GO:0016192:vesicle-mediated transport]" - - - - - - - - - - ENSG00000274104 19 34733298 34733837 540 - - 1.439578136 0.88332764 2.107382819 0.68182837 0.452759684 0.134074906 10.68371605 7.365296437 15.01287265 4.861202299 3.292333856 0.954875033 7.028382721 1.868642259 0.038033593 0.985614865 UP - - - - - - - - - - - - ENSG00000225265 1 222589825 222593843 8176 + TAF1A-AS1 0.156280848 0.150690884 0.125827811 0.260548302 0.216267341 1.024685703 4.856234569 5.260926026 3.753218162 7.777923679 6.584667713 30.55600105 9.798161867 -1.705292723 0.038111757 0.985614865 DOWN - - - - - - - - - - - - ENSG00000131067 20 34844720 34872856 4744 - GGT7 0 0 0.048024423 0.19888579 0.027514093 0.244430956 0 0 1.876609081 7.777923679 1.097444619 9.548750329 3.383454618 -3.259645232 0.039011719 0.985614865 DOWN gamma-glutamyltransferase 7 [Source:HGNC Symbol;Acc:HGNC:4259] "[GO:0036374:glutathione hydrolase activity][GO:0006751:glutathione catabolic process][GO:0006412:translation][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0016740:transferase activity][GO:0016787:hydrolase activity][GO:0016746:transferase activity, transferring acyl groups][GO:0005515:protein binding][GO:0006508:proteolysis][GO:0005886:plasma membrane][GO:0006749:glutathione metabolic process][GO:0006750:glutathione biosynthetic process][GO:0032496:response to lipopolysaccharide][GO:0007283:spermatogenesis][GO:1901750:leukotriene D4 biosynthetic process][GO:0032355:response to estradiol][GO:0034612:response to tumor necrosis factor][GO:1902883:negative regulation of response to oxidative stress][GO:0000048:peptidyltransferase activity][GO:0036374:glutathione hydrolase activity][GO:0102953:hypoglycin A gamma-glutamyl transpeptidase activity][GO:0103068:leukotriene C4 gamma-glutamyl transferase activity][GO:0006751:glutathione catabolic process][GO:0006508:proteolysis][GO:0036374:glutathione hydrolase activity][GO:0006751:glutathione catabolic process][GO:0036374:glutathione hydrolase activity][GO:0006751:glutathione catabolic process][GO:0006508:proteolysis][GO:0036374:glutathione hydrolase activity][GO:0006751:glutathione catabolic process][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0006508:proteolysis]" [hsa00430:Taurine and hypotaurine metabolism][hsa00480:Glutathione metabolism] - - - - - - - - - ENSG00000237732 2 222318275 222352989 8334 + CT75 0.023486274 0 0 0.171306829 0.081252984 0.072183898 0.971246914 0 0 6.805683219 3.292333856 2.864625099 2.322314848 -3.614362253 0.039448848 0.985614865 DOWN - - - - - - - - - - - - ENSG00000270605 1 28239509 28241453 1945 - - 0.436011513 0.140138649 0.438812361 0.946496965 0.50280767 1.079492559 11.65496297 4.208740821 11.25965449 24.3060115 13.16933543 27.69137595 15.38168019 -1.260668824 0.039784768 0.985614865 DOWN - - - - - - - - - - - - ENSG00000267390 18 63367295 63381631 820 + KDSR-DT 0.17236634 0.08310051 0 0.538810712 0.695703905 0.529759384 1.942493828 1.052185205 0 5.833442759 7.682112331 5.729250197 3.70658072 -2.692892398 0.039821516 0.985614865 DOWN - - - - - - - - - - - - ENSG00000275322 15 96342953 96345651 1133 + - 0.124748807 0.30071676 0.251100336 0.844913531 0.719300469 0.766818526 1.942493828 5.260926026 3.753218162 12.63912598 10.97444619 11.45850039 7.671451763 -1.687045788 0.039876172 0.985614865 DOWN - - - - - - - - - - - - ENSG00000215835 1 166275629 166277597 1969 - - 0.502479833 1.34969746 0.794683465 0.673171331 0.248339491 0.257391135 13.59745679 41.035223 20.64269989 17.50032828 6.584667713 6.68412523 17.67408348 1.280634094 0.040065645 0.985614865 UP - - - - - - - - - - - - ENSG00000279233 12 125138245 125141711 3467 + - 0.203836745 0.117927461 0.061543845 0.254874406 0.399609066 0.438537477 9.712469138 6.313111231 2.814913622 11.66688552 18.65655852 20.05237569 11.53605229 -1.42160568 0.040439071 0.985614865 DOWN - - - - - - - - - - - - ENSG00000234841 4 112826307 112827607 1301 + - 0.271599537 0.157130864 0.273344236 0.056600664 0 0 4.856234569 3.156555616 4.691522703 0.97224046 0 0 2.279425558 3.556263812 0.041804454 0.985614865 UP - - - - - - - - - - - - ENSG00000281332 7 32760279 32762924 2646 + LINC00997 0.320499771 1.313402613 0.430078126 0.417445941 0.184799871 0.300984483 11.65496297 53.66144547 15.01287265 14.5836069 6.584667713 10.50362536 18.66686351 1.33032114 0.041806419 0.985614865 UP - - - - - - - - - - - - ENSG00000220937 9 4944670 4945902 928 - HNRNPA1P41 0.076153232 0.220287989 0.076642425 0.396753577 0.526918598 1.014230431 0.971246914 3.156555616 0.938304541 4.861202299 6.584667713 12.41337543 4.820892085 -2.260160124 0.04191148 0.985614865 DOWN - - - - - - - - - - - - ENSG00000167964 16 2140803 2154165 9069 + RAB26 0.312448631 0.16433059 0.228695081 0.651135131 0.425827034 0.669296757 10.68371605 6.313111231 7.506436324 21.38929012 14.26678004 21.96212576 13.68690992 -1.234251478 0.042575483 0.985614865 DOWN "RAB26, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:14259]" "[GO:0003924:GTPase activity][GO:0005525:GTP binding][GO:0005525:GTP binding][GO:0003924:GTPase activity][GO:0016020:membrane][GO:0015031:protein transport][GO:0000166:nucleotide binding][GO:0005794:Golgi apparatus][GO:0005525:GTP binding][GO:0005525:GTP binding][GO:0031410:cytoplasmic vesicle][GO:0000139:Golgi membrane][GO:0000139:Golgi membrane][GO:0005515:protein binding][GO:0005794:Golgi apparatus][GO:0030658:transport vesicle membrane][GO:0031226:intrinsic component of plasma membrane][GO:0005768:endosome][GO:0045055:regulated exocytosis][GO:0030667:secretory granule membrane][GO:0017157:regulation of exocytosis][GO:0098993:anchored component of synaptic vesicle membrane][GO:0098993:anchored component of synaptic vesicle membrane][GO:0098993:anchored component of synaptic vesicle membrane][GO:0043001:Golgi to plasma membrane protein transport][GO:0019002:GMP binding][GO:0035272:exocrine system development][GO:0035272:exocrine system development][GO:0099575:regulation of protein catabolic process at presynapse, modulating synaptic transmission][GO:0099575:regulation of protein catabolic process at presynapse, modulating synaptic transmission][GO:0005525:GTP binding][GO:0003924:GTPase activity][GO:0016020:membrane][GO:0015031:protein transport][GO:0000166:nucleotide binding][GO:0005794:Golgi apparatus][GO:0005525:GTP binding][GO:0005525:GTP binding][GO:0031410:cytoplasmic vesicle][GO:0000139:Golgi membrane][GO:0000139:Golgi membrane][GO:0005515:protein binding][GO:0005794:Golgi apparatus][GO:0030658:transport vesicle membrane][GO:0031226:intrinsic component of plasma membrane][GO:0005768:endosome][GO:0045055:regulated exocytosis][GO:0030667:secretory granule membrane][GO:0017157:regulation of exocytosis][GO:0098993:anchored component of synaptic vesicle membrane][GO:0098993:anchored component of synaptic vesicle membrane][GO:0098993:anchored component of synaptic vesicle membrane][GO:0043001:Golgi to plasma membrane protein transport][GO:0019002:GMP binding][GO:0017157:regulation of exocytosis][GO:0035272:exocrine system development][GO:0035272:exocrine system development][GO:0035272:exocrine system development][GO:0099575:regulation of protein catabolic process at presynapse, modulating synaptic transmission][GO:0099575:regulation of protein catabolic process at presynapse, modulating synaptic transmission][GO:0031226:intrinsic component of plasma membrane]" - - - - - - - - - - ENSG00000168918 2 233059967 233207903 21926 + INPP5D 0.02442237 0.039248023 0.03277234 0.127239023 0.065715609 0.125101571 2.913740741 5.260926026 3.753218162 14.5836069 7.682112331 14.32312549 8.086121609 -1.628172043 0.042786414 0.985614865 DOWN inositol polyphosphate-5-phosphatase D [Source:HGNC Symbol;Acc:HGNC:6079] "[GO:0003824:catalytic activity][GO:0016791:phosphatase activity][GO:0046856:phosphatidylinositol dephosphorylation][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005829:cytosol][GO:0005886:plasma membrane][GO:0016787:hydrolase activity][GO:0006915:apoptotic process][GO:0005856:cytoskeleton][GO:0045121:membrane raft][GO:0017124:SH3 domain binding][GO:0005515:protein binding][GO:0002376:immune system process][GO:0004445:inositol-polyphosphate 5-phosphatase activity][GO:0052658:inositol-1,4,5-trisphosphate 5-phosphatase activity][GO:0052659:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity][GO:0004439:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity][GO:0005829:cytosol][GO:0007165:signal transduction][GO:0006661:phosphatidylinositol biosynthetic process][GO:0006796:phosphate-containing compound metabolic process][GO:0050852:T cell receptor signaling pathway][GO:0034485:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity][GO:0034485:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity][GO:0016314:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity][GO:0004445:inositol-polyphosphate 5-phosphatase activity][GO:0003824:catalytic activity][GO:0016791:phosphatase activity][GO:0046856:phosphatidylinositol dephosphorylation][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005829:cytosol][GO:0005886:plasma membrane][GO:0016787:hydrolase activity][GO:0006915:apoptotic process][GO:0005856:cytoskeleton][GO:0045121:membrane raft][GO:0017124:SH3 domain binding][GO:0005515:protein binding][GO:0002376:immune system process][GO:0004445:inositol-polyphosphate 5-phosphatase activity][GO:0052658:inositol-1,4,5-trisphosphate 5-phosphatase activity][GO:0052659:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity][GO:0004439:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity][GO:0005829:cytosol][GO:0007165:signal transduction][GO:0006661:phosphatidylinositol biosynthetic process][GO:0006796:phosphate-containing compound metabolic process][GO:0050852:T cell receptor signaling pathway][GO:0034485:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity][GO:0034485:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity][GO:0016314:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity][GO:0004445:inositol-polyphosphate 5-phosphatase activity][GO:0008340:determination of adult lifespan][GO:0009968:negative regulation of signal transduction][GO:0016064:immunoglobulin mediated immune response][GO:0030853:negative regulation of granulocyte differentiation][GO:0030889:negative regulation of B cell proliferation][GO:0032715:negative regulation of interleukin-6 production][GO:0035556:intracellular signal transduction][GO:0043065:positive regulation of apoptotic process][GO:0045579:positive regulation of B cell differentiation][GO:0045621:positive regulation of lymphocyte differentiation][GO:0045648:positive regulation of erythrocyte differentiation][GO:0045656:negative regulation of monocyte differentiation][GO:0045659:negative regulation of neutrophil differentiation][GO:0045671:negative regulation of osteoclast differentiation][GO:0045779:negative regulation of bone resorption][GO:0050777:negative regulation of immune response][GO:0050869:negative regulation of B cell activation][GO:0003824:catalytic activity][GO:0016791:phosphatase activity][GO:0046856:phosphatidylinositol dephosphorylation][GO:0005829:cytosol][GO:0016787:hydrolase activity][GO:0006796:phosphate-containing compound metabolic process][GO:0019637:organophosphate metabolic process]" [hsa00562:Inositol phosphate metabolism][hsa04070:Phosphatidylinositol signaling system][hsa04662:B cell receptor signaling pathway][hsa04664:Fc epsilon RI signaling pathway][hsa04666:Fc gamma R-mediated phagocytosis] - - - - - - - - - ENSG00000170667 7 102479976 102517777 18221 - RASA4B 0.048371115 0.074625509 0.019472737 0.110884614 0.122719257 0.21804379 4.856234569 8.417481642 1.876609081 10.69464506 12.07189081 21.00725072 9.820685313 -1.548092792 0.043347931 0.985614865 DOWN RAS p21 protein activator 4B [Source:HGNC Symbol;Acc:HGNC:35202] [GO:0007165:signal transduction][GO:0005096:GTPase activator activity][GO:0035556:intracellular signal transduction][GO:0005543:phospholipid binding][GO:0043087:regulation of GTPase activity][GO:0046580:negative regulation of Ras protein signal transduction][GO:0071277:cellular response to calcium ion][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0046872:metal ion binding][GO:0005886:plasma membrane][GO:0005829:cytosol][GO:0007165:signal transduction][GO:0035556:intracellular signal transduction][GO:0043087:regulation of GTPase activity][GO:0005096:GTPase activator activity][GO:0007165:signal transduction][GO:0005096:GTPase activator activity][GO:0035556:intracellular signal transduction][GO:0005543:phospholipid binding][GO:0043087:regulation of GTPase activity][GO:0046580:negative regulation of Ras protein signal transduction][GO:0071277:cellular response to calcium ion][GO:0046872:metal ion binding][GO:0000165:MAPK cascade] [hsa04014:Ras signaling pathway] - - - - - - - - - ENSG00000267637 17 59784813 59785035 223 + - 0 0 0 0.990638528 1.461824988 0.649331383 0 0 0 2.916721379 4.389778475 1.909750066 1.536041653 -4.077628148 0.043855884 0.985614865 DOWN - - - - - - - - - - - - ENSG00000229635 1 93384487 93384998 512 - - 0.4140832 0.39927198 0.972400764 0.143823172 0 0 2.913740741 3.156555616 6.568131784 0.97224046 0 0 2.268444767 3.549942899 0.044054876 0.985614865 UP - - - - - - - - - - - - ENSG00000186523 8 12182096 12194133 24613 - FAM86B1 0.217087097 0.096610233 0.218481619 0.365403294 0.462174347 0.376372846 12.62620988 6.313111231 12.19795903 20.41704966 26.33867085 21.00725072 16.48337523 -1.112662865 0.04578681 0.985614865 DOWN family with sequence similarity 86 member B1 [Source:HGNC Symbol;Acc:HGNC:28268] [GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation][GO:0016740:transferase activity][GO:0008168:methyltransferase activity][GO:0032259:methylation] - - - - - - - - - - ENSG00000180806 12 53994895 54003337 3560 + HOXC9 0.042419087 0.040901811 0 0.221000792 0.440258516 0.086915305 0.971246914 1.052185205 0 4.861202299 9.877001569 1.909750066 3.111897675 -3.055737193 0.046344629 0.985614865 DOWN homeobox C9 [Source:HGNC Symbol;Acc:HGNC:5130] "[GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005634:nucleus][GO:0006351:transcription, DNA-templated][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0005654:nucleoplasm][GO:0005515:protein binding][GO:0016235:aggresome][GO:0006357:regulation of transcription by RNA polymerase II][GO:0005634:nucleus][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0003700:DNA-binding transcription factor activity][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:1990837:sequence-specific double-stranded DNA binding][GO:0009952:anterior/posterior pattern specification][GO:0048704:embryonic skeletal system morphogenesis][GO:0009954:proximal/distal pattern formation][GO:0003677:DNA binding][GO:0006355:regulation of transcription, DNA-templated][GO:0005634:nucleus][GO:0006351:transcription, DNA-templated][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0005654:nucleoplasm][GO:0005515:protein binding][GO:0016235:aggresome][GO:0006357:regulation of transcription by RNA polymerase II][GO:0009952:anterior/posterior pattern specification][GO:0048704:embryonic skeletal system morphogenesis][GO:0048706:embryonic skeletal system development][GO:0005634:nucleus][GO:0006357:regulation of transcription by RNA polymerase II][GO:0000978:RNA polymerase II proximal promoter sequence-specific DNA binding][GO:0003700:DNA-binding transcription factor activity][GO:0000981:DNA-binding transcription factor activity, RNA polymerase II-specific][GO:0000785:chromatin][GO:1990837:sequence-specific double-stranded DNA binding][GO:0009952:anterior/posterior pattern specification][GO:0048704:embryonic skeletal system morphogenesis][GO:0009954:proximal/distal pattern formation]" - - - - - - - - - - ENSG00000267544 19 10841839 10842250 412 + HIKESHIP2 1.372236882 0.661576873 1.208420366 0.178731709 0 0.351458491 7.769975311 4.208740821 6.568131784 0.97224046 0 1.909750066 3.571473073 2.649352459 0.046494939 0.985614865 UP - - - - - - - - - - - - ENSG00000259165 14 69083398 69085389 1992 + DDX18P1 0.106431023 0.30787237 0.035704905 0.036966598 0 0 2.913740741 9.469666847 0.938304541 0.97224046 0 0 2.382325431 3.614054408 0.04660407 0.985614865 UP - - - - - - - - - - - - ENSG00000182600 2 232857270 232878708 6444 + SNORC 0.305766141 0.092134151 0.211564595 0.457993962 0.528913422 0.411143708 15.53995062 5.260926026 10.32134995 22.36153058 26.33867085 20.05237569 16.64580062 -1.134496574 0.046939976 0.985614865 DOWN secondary ossification center associated regulator of chondrocyte maturation [Source:HGNC Symbol;Acc:HGNC:33763] [GO:0051216:cartilage development][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0071944:cell periphery][GO:0051216:cartilage development][GO:0071944:cell periphery][GO:0051216:cartilage development][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0071944:cell periphery][GO:0051216:cartilage development][GO:0071944:cell periphery][GO:0051216:cartilage development][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0016021:integral component of membrane][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0071944:cell periphery][GO:0051216:cartilage development][GO:0062023:collagen-containing extracellular matrix][GO:0071944:cell periphery][GO:0071944:cell periphery] - - - - - - - - - - ENSG00000231989 5 156850295 156852528 2234 + PPP1R2B 0 0 0 0.131848637 0.072960379 0.097225312 0 0 0 3.888961839 2.194889238 2.864625099 1.491412696 -4.041943435 0.047033304 0.985614865 DOWN PPP1R2 family member B [Source:HGNC Symbol;Acc:HGNC:16318] [GO:0009966:regulation of signal transduction][GO:0004864:protein phosphatase inhibitor activity][GO:0043666:regulation of phosphoprotein phosphatase activity][GO:0005975:carbohydrate metabolic process][GO:0005977:glycogen metabolic process][GO:0005515:protein binding][GO:0004864:protein phosphatase inhibitor activity][GO:0043666:regulation of phosphoprotein phosphatase activity] - - - - - - - - - - ENSG00000213089 6 150827663 150828384 722 + PDCL3P5 0 0.09438008 0.098509931 0.611945683 0.338629126 0.701943413 0 1.052185205 0.938304541 5.833442759 3.292333856 6.68412523 2.966731932 -3.00435983 0.047051936 0.985614865 DOWN - - - - - - - - - - - - ENSG00000232082 6 166460663 166465383 579 - RPS6KA2-IT1 0 0 0 0.635902106 0.703771529 0 0 0 0 4.861202299 5.487223094 0 1.724737565 -4.244073739 0.048108459 0.985614865 DOWN - - - - - - - - - - - - ENSG00000186081 12 52514575 52520530 10522 - KRT5 0.051297024 0.065949594 0.034417697 0 0 0 2.913740741 4.208740821 1.876609081 0 0 0 1.499848441 4.015166272 0.048615434 0.985614865 UP keratin 5 [Source:HGNC Symbol;Acc:HGNC:6442] [GO:0045095:keratin filament][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0016020:membrane][GO:0005515:protein binding][GO:0007010:cytoskeleton organization][GO:0005882:intermediate filament][GO:0005829:cytosol][GO:0070062:extracellular exosome][GO:0005200:structural constituent of cytoskeleton][GO:0097110:scaffold protein binding][GO:0008544:epidermis development][GO:0045095:keratin filament][GO:0005882:intermediate filament][GO:0005882:intermediate filament][GO:0045095:keratin filament][GO:0005829:cytosol][GO:0005882:intermediate filament][GO:0070268:cornification][GO:0045095:keratin filament][GO:0005829:cytosol][GO:0005882:intermediate filament][GO:0070268:cornification][GO:0045095:keratin filament][GO:0005829:cytosol][GO:0005882:intermediate filament][GO:0070268:cornification] - - - - - - - - - - ENSG00000186666 12 49836043 49843106 4355 - BCDIN3D 0.21044185 0.332042101 0.057761914 0.518292924 0.661857686 0.352790494 10.68371605 18.93933369 2.814913622 25.27825196 32.92333856 17.18775059 17.97121741 -1.225857234 0.048821037 0.985614865 DOWN BCDIN3 domain containing RNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:27050] [GO:0008168:methyltransferase activity][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0016740:transferase activity][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0008171:O-methyltransferase activity][GO:0008175:tRNA methyltransferase activity][GO:0032259:methylation][GO:0005515:protein binding][GO:0001510:RNA methylation][GO:0005737:cytoplasm][GO:0008171:O-methyltransferase activity][GO:0005829:cytosol][GO:0030488:tRNA methylation][GO:0008173:RNA methyltransferase activity][GO:0010586:miRNA metabolic process][GO:0008173:RNA methyltransferase activity][GO:0008171:O-methyltransferase activity][GO:0010586:miRNA metabolic process][GO:0010586:miRNA metabolic process][GO:0061715:miRNA 2'-O-methylation][GO:2000632:negative regulation of pre-miRNA processing][GO:2000632:negative regulation of pre-miRNA processing] - - - - - - - - - - ENSG00000163216 1 153039732 153041931 3047 - SPRR2D 0 0 0 0.139995179 0.154936774 0.344108599 0 0 0 1.94448092 2.194889238 4.774375164 1.48562422 -4.037089338 0.04923453 0.985614865 DOWN small proline rich protein 2D [Source:HGNC Symbol;Acc:HGNC:11264] [GO:0001533:cornified envelope][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0031424:keratinization][GO:0005829:cytosol][GO:0008544:epidermis development][GO:0001533:cornified envelope][GO:0001533:cornified envelope][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0031424:keratinization][GO:0005829:cytosol][GO:0008544:epidermis development][GO:0001533:cornified envelope][GO:0001533:cornified envelope][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0031424:keratinization][GO:0005829:cytosol][GO:0008544:epidermis development][GO:0001533:cornified envelope][GO:0001533:cornified envelope][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0031424:keratinization][GO:0005829:cytosol][GO:0008544:epidermis development][GO:0001533:cornified envelope] - - - - - - - - - - ENSG00000089127 12 112905856 112933219 66614 + OAS1 0.027137009 0.020933083 0.027311332 0.050897564 0.068847567 0.105645383 4.856234569 4.208740821 4.691522703 8.750164138 12.07189081 18.14262562 8.78686311 -1.502147092 0.049297172 0.985614865 DOWN 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] [GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0046872:metal ion binding][GO:0000166:nucleotide binding][GO:0005524:ATP binding][GO:0005524:ATP binding][GO:0016740:transferase activity][GO:0005783:endoplasmic reticulum][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0043231:intracellular membrane-bounded organelle][GO:0005739:mitochondrion][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0006006:glucose metabolic process][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0032760:positive regulation of tumor necrosis factor production][GO:0042742:defense response to bacterium][GO:0051259:protein complex oligomerization][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0042593:glucose homeostasis][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0032728:positive regulation of interferon-beta production][GO:0034138:toll-like receptor 3 signaling pathway][GO:0034142:toll-like receptor 4 signaling pathway][GO:0035458:cellular response to interferon-beta][GO:0043129:surfactant homeostasis][GO:0045071:negative regulation of viral genome replication][GO:0060339:negative regulation of type I interferon-mediated signaling pathway][GO:0060700:regulation of ribonuclease activity][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:0071639:positive regulation of monocyte chemotactic protein-1 production][GO:0071659:negative regulation of IP-10 production][GO:0098586:cellular response to virus][GO:2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production][GO:0035457:cellular response to interferon-alpha][GO:1901857:positive regulation of cellular respiration][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0046872:metal ion binding][GO:0000166:nucleotide binding][GO:0005524:ATP binding][GO:0005524:ATP binding][GO:0016740:transferase activity][GO:0005783:endoplasmic reticulum][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0043231:intracellular membrane-bounded organelle][GO:0005739:mitochondrion][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0006006:glucose metabolic process][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0032760:positive regulation of tumor necrosis factor production][GO:0042742:defense response to bacterium][GO:0005634:nucleus][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0042593:glucose homeostasis][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0032728:positive regulation of interferon-beta production][GO:0034138:toll-like receptor 3 signaling pathway][GO:0034142:toll-like receptor 4 signaling pathway][GO:0035458:cellular response to interferon-beta][GO:0043129:surfactant homeostasis][GO:0045071:negative regulation of viral genome replication][GO:0060339:negative regulation of type I interferon-mediated signaling pathway][GO:0060700:regulation of ribonuclease activity][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:0071639:positive regulation of monocyte chemotactic protein-1 production][GO:0071659:negative regulation of IP-10 production][GO:0098586:cellular response to virus][GO:2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0005737:cytoplasm][GO:0043231:intracellular membrane-bounded organelle][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0043231:intracellular membrane-bounded organelle][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0046872:metal ion binding][GO:0000166:nucleotide binding][GO:0005524:ATP binding][GO:0005524:ATP binding][GO:0016740:transferase activity][GO:0005783:endoplasmic reticulum][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0043231:intracellular membrane-bounded organelle][GO:0005739:mitochondrion][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0006006:glucose metabolic process][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0032760:positive regulation of tumor necrosis factor production][GO:0042742:defense response to bacterium][GO:0005634:nucleus][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0042593:glucose homeostasis][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0032728:positive regulation of interferon-beta production][GO:0034138:toll-like receptor 3 signaling pathway][GO:0034142:toll-like receptor 4 signaling pathway][GO:0035458:cellular response to interferon-beta][GO:0043129:surfactant homeostasis][GO:0045071:negative regulation of viral genome replication][GO:0060339:negative regulation of type I interferon-mediated signaling pathway][GO:0060700:regulation of ribonuclease activity][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:0071639:positive regulation of monocyte chemotactic protein-1 production][GO:0071659:negative regulation of IP-10 production][GO:0098586:cellular response to virus][GO:2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production][GO:0060337:type I interferon signaling pathway][GO:0005739:mitochondrion][GO:0005840:ribosome][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003725:double-stranded RNA binding][GO:0043231:intracellular membrane-bounded organelle][GO:0016779:nucleotidyltransferase activity][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0003723:RNA binding][GO:0005634:nucleus][GO:0005737:cytoplasm][GO:0005737:cytoplasm][GO:0046872:metal ion binding][GO:0000166:nucleotide binding][GO:0005524:ATP binding][GO:0005524:ATP binding][GO:0016740:transferase activity][GO:0005783:endoplasmic reticulum][GO:0005654:nucleoplasm][GO:0005829:cytosol][GO:0043231:intracellular membrane-bounded organelle][GO:0005739:mitochondrion][GO:0005576:extracellular region][GO:0005515:protein binding][GO:0002376:immune system process][GO:0045087:innate immune response][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0005829:cytosol][GO:0005654:nucleoplasm][GO:0016020:membrane][GO:0006006:glucose metabolic process][GO:0005829:cytosol][GO:0009615:response to virus][GO:0045071:negative regulation of viral genome replication][GO:0051607:defense response to virus][GO:0032760:positive regulation of tumor necrosis factor production][GO:0042742:defense response to bacterium][GO:0005634:nucleus][GO:0003725:double-stranded RNA binding][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0042593:glucose homeostasis][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0032728:positive regulation of interferon-beta production][GO:0034138:toll-like receptor 3 signaling pathway][GO:0034142:toll-like receptor 4 signaling pathway][GO:0035458:cellular response to interferon-beta][GO:0043129:surfactant homeostasis][GO:0045071:negative regulation of viral genome replication][GO:0060339:negative regulation of type I interferon-mediated signaling pathway][GO:0060700:regulation of ribonuclease activity][GO:0060700:regulation of ribonuclease activity][GO:0070106:interleukin-27-mediated signaling pathway][GO:0071639:positive regulation of monocyte chemotactic protein-1 production][GO:0071659:negative regulation of IP-10 production][GO:0098586:cellular response to virus][GO:2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0043231:intracellular membrane-bounded organelle][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0016779:nucleotidyltransferase activity][GO:0003725:double-stranded RNA binding][GO:0051607:defense response to virus][GO:0001730:2'-5'-oligoadenylate synthetase activity][GO:0043231:intracellular membrane-bounded organelle] [hsa04621:NOD-like receptor signaling pathway][hsa05160:Hepatitis C][hsa05162:Measles][hsa05164:Influenza A][hsa05168:Herpes simplex infection] - - - - - - - - - ENSG00000263272 17 5425139 5432876 1938 - - 0.510517436 0.246128445 0.550496673 0.835925803 1.051299576 0.933958323 13.59745679 7.365296437 14.07456811 21.38929012 27.43611547 23.87187582 17.95576712 -1.044626908 0.049739475 0.985614865 DOWN - - - - - - - - - - - -