FN Clarivate Analytics Web of Science VR 1.0 PT J AU Mohammad-Rahimi, Hossein Motamedian, Saeed Reza Rohban, Mohammad Hossein Krois, Joachim Uribe, Sergio E. Mahmoudinia, Erfan Rokhshad, Rata Nadimi, Mohadeseh Schwendicke, Falk TI Deep learning for caries detection: A systematic review SO JOURNAL OF DENTISTRY VL 122 AR 104115 DI 10.1016/j.jdent.2022.104115 EA MAY 2022 DT Review PD JUL 2022 PY 2022 AB Objectives: Detecting caries lesions is challenging for dentists, and deep learning models may help practitioners to increase accuracy and reliability. We aimed to systematically review deep learning studies on caries detection. Data: We selected diagnostic accuracy studies that used deep learning models on dental imagery (including radiographs, photographs, optical coherence tomography images, near-infrared light transillumination images). The latest version of the quality assessment tool for diagnostic accuracy studies (QUADAS-2) tool was used for risk of bias assessment. Meta-analysis was not performed due to heterogeneity in the studies methods and their performance measurements. Sources: Databases (Medline via PubMed, Google Scholar, Scopus, Embase) and a repository (ArXiv) were screened for publications published after 2010, without any limitation on language. Study selection: From 252 potentially eligible references, 48 studies were assessed full-text and 42 included, using classification (n = 26), object detection (n = 6), or segmentation models (n = 10). A wide range of performance metrics was used; image, object or pixel accuracy ranged between 68%-99%. The minority of studies (n = 11) showed a low risk of biases in all domains, and 13 studies (31.0%) low risk for concerns regarding applicability. The accuracy of caries classification models varied, i.e. 71% to 96% on intra-oral photographs, 82% to 99.2% on peri-apical radiographs, 87.6% to 95.4% on bitewing radiographs, 68.0% to 78.0% on near-infrared transillumination images, 88.7% to 95.2% on optical coherence tomography images, and 86.1% to 96.1% on panoramic radiographs. Pooled diagnostic odds ratios varied from 2.27 to 32,767. For detection and segmentation models, heterogeneity in reporting did not allow useful pooling. Conclusion: An increasing number of studies investigated caries detection using deep learning, with a diverse types of architectures being employed. Reported accuracy seems promising, while study and reporting quality are currently low. Clinical significance: Deep learning models can be considered as an assistant for decisions regarding the presence or absence of carious lesions. RI Motamedian, Saeed Reza/V-3294-2018; Uribe, Sergio E./C-9579-2011; Krois, Joachim/; Rokhshad, Rata/; Schwendicke, Falk/; Mohammad-Rahimi, Hossein/ OI Motamedian, Saeed Reza/0000-0001-7337-2145; Uribe, Sergio E./0000-0003-0684-2025; Krois, Joachim/0000-0002-6010-8940; Rokhshad, Rata/0000-0001-9668-7684; Schwendicke, Falk/0000-0003-1223-1669; Mohammad-Rahimi, Hossein/0000-0002-4971-5926 Z8 1 ZR 0 ZA 0 ZB 5 TC 36 ZS 0 Z9 37 C1 ITU WHO Focus Grp Hlth, Top Grp Dent Diagnost & Digital Dent, Berlin, Germany C1 Sharif Univ Technol, Dept Comp Engn, Tehran, Iran C1 Shahid Beheshti Univ Med Sci, Res Inst Dent Sci & Dept Orthodont, Dentofacial Deform Res Ctr, Sch Dent, Tehran, Iran C1 Charite Univ Med Berlin, Dept Oral Diagnost, Digital Hlth & Hlth Serv Res, Berlin, Germany C1 Riga Stradins Univ, Dept Conservat Dent & Oral Hlth, Riga, Latvia C1 Riga Stradins Univ, Bioinformat Res Unit, Riga, Latvia C1 Univ Austral Chile, Sch Dent, Valdivia, Chile C1 Headquarters Riga Tech Univ, Balt Biomat Ctr Excellence, Riga, Latvia C1 Guilan Univ Med Sci, Heshmat Hosp, Cardiovasc Dis Res Ctr, Sch Med, Rasht, Iran C3 ITU WHO Focus Grp Hlth C3 Headquarters Riga Tech Univ C3 Guilan Univ Med Sci SN 0300-5712 EI 1879-176X DA 2022-06-14 UT WOS:000804944200002 PM 35367318 ER PT J AU Al-Namankany, Abeer TI Influence of Artificial Intelligence-Driven Diagnostic Tools on Treatment Decision-Making in Early Childhood Caries: A Systematic Review of Accuracy and Clinical Outcomes. SO Dentistry journal VL 11 IS 9 DI 10.3390/dj11090214 DT Journal Article; Review PD 2023 Sep 12 PY 2023 AB Early detection and accurate prediction of the risk of early childhood caries (ECC) are essential for effective prevention and management. This systematic review aims to assess the performance and applicability of machine learning algorithms in ECC prediction and detection. A comprehensive search was conducted to identify studies utilizing machine learning algorithms to predict or detect ECC. The included (n = 6) studies demonstrated high accuracy, sensitivity, specificity, and area under the receiver operating characteristic (AUC) values related to predicting and detecting ECC. The application of machine learning algorithms contributed to enhanced clinical decision-making, targeted preventive measures, and improved ECC management. The studies also highlighted the importance of considering multiple factors, including demographic, environmental, and genetic factors, when developing dental caries prediction models. Machine learning algorithms hold significant potential for ECC prediction and detection, having promising performance outcomes. Due to the heterogeneity of the studies, no meta-analysis could be performed. Moreover, further research is needed to explore the feasibility, acceptability, and effectiveness of integrating these algorithms into dental practice. This approach would ultimately contribute to enabling more effective and personalized dental caries management and improved oral health outcomes for diverse populations. RI Al-Namankany, Abeer/AHB-1583-2022 OI Al-Namankany, Abeer/0000-0001-9335-5940 ZS 0 Z8 0 ZA 0 ZB 0 TC 0 ZR 0 Z9 0 C1 Paediatric Dentistry and Orthodontics Department, College of Dentistry, Taibah University, P.O. Box 41141, Almadinah Almunawwarah 38008, Saudi Arabia. EI 2304-6767 DA 2023-09-28 UT MEDLINE:37754334 PM 37754334 ER PT J AU Talpur, Sarena Azim, Fahad Rashid, Munaf Syed, Sidra Abid Talpur, Baby Alisha Khan, Saad Jawaid TI Uses of Different Machine Learning Algorithms for Diagnosis of Dental Caries SO JOURNAL OF HEALTHCARE ENGINEERING VL 2022 AR 5032435 DI 10.1155/2022/5032435 DT Review PD MAR 31 2022 PY 2022 AB Background. Dental caries is one of the major oral health problems and is increasing rapidly among people of every age (children, men, and women). Deep learning, a field of Artificial Intelligence (AI), is a growing field nowadays and is commonly used in dentistry. AI is a reliable platform to make dental care better, smoother, and time-saving for professionals. AI helps the dentistry professionals to fulfil demands of patients and to ensure quality treatment and better oral health care. AI can also help in predicting failures of clinical cases and gives reliable solutions. In this way, it helps in reducing morbidity ratio and increasing quality treatment of dental problem in population. Objectives. The main objective of this study is to conduct a systematic review of studies concerning the association between dental caries and machine learning. The objective of this study is to design according to the PICO criteria. Materials and Methods. A systematic search for randomized trials was conducted under the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). In this study, e-search was conducted from four databases including PubMed, IEEE Xplore, Science Direct, and Google Scholar, and it involved studies from year 2008 to 2022. Result. This study fetched a total of 133 articles, from which twelve are selected for this systematic review. We analyzed different types of machine learning algorithms from which deep learning is widely used with dental caries images dataset. Neural Network Backpropagation algorithm, one of the deep learning algorithms, gives a maximum accuracy of 99%. Conclusion. In this systematic review, we concluded how deep learning has been applied to the images of teeth to diagnose the detection of dental caries with its three types (proximal, occlusal, and root caries). Considering our findings, further well-designed studies are needed to demonstrate the diagnosis of further types of dental caries that are based on progression (chronic, acute, and arrested), which tells us about the severity of caries, virginity of lesion, and extent of caries. Apart from dental caries, AI in the future will emerge as supreme technology to detect other diseases of oral region combinedly and comprehensively because AI will easily analyze big datasets that contain multiple records. OI Azim, Choudhry Fahad/0000-0001-6737-4953; Rashid, Sheikh Muhammad Munaf/0000-0003-2063-4513; Syed, Sidra Abid/0000-0002-0647-8270 TC 6 Z8 0 ZS 0 ZA 0 ZB 1 ZR 0 Z9 7 C1 Ziauddin Univ, Dept Biomed Engn, Karachi, Pakistan C1 Ziauddin Univ, Dept Elect Engn, Karachi, Pakistan C1 Ziauddin Univ, Dept Software Engn, Karachi, Pakistan C1 Liaquat Univ Med & Hlth Sci, Jamshoro, Pakistan SN 2040-2295 EI 2040-2309 DA 2022-05-27 UT WOS:000793539700012 PM 35399834 ER PT B AU Shindé, Manila Z2 TI Evaluation of Performance of Deep Learning Algorithms in Detecting and Diagnosing Dental Carious Lesions Using Intraoral Radiographic Imaging: A Systematic Review and Meta-Analysis DT Dissertation/Thesis PD Jan 01 2022 PY 2022 ZA 0 TC 0 ZR 0 ZS 0 Z8 0 ZB 0 Z9 0 C1 The University of Iowa, Oral Science, Iowa, United States C3 The University of Iowa BN 9798845425768 UT PQDT:68523276 ER PT J AU Prados-Privado, Maria Garcia Villalon, Javier Martinez-Martinez, Carlos Hugo Ivorra, Carlos Prados-Frutos, Juan Carlos TI Dental Caries Diagnosis and Detection Using Neural Networks: A Systematic Review SO JOURNAL OF CLINICAL MEDICINE VL 9 IS 11 AR 3579 DI 10.3390/jcm9113579 DT Review PD NOV 2020 PY 2020 AB Dental caries is the most prevalent dental disease worldwide, and neural networks and artificial intelligence are increasingly being used in the field of dentistry. This systematic review aims to identify the state of the art of neural networks in caries detection and diagnosis. A search was conducted in PubMed, Institute of Electrical and Electronics Engineers (IEEE) Xplore, and ScienceDirect. Data extraction was performed independently by two reviewers. The quality of the selected studies was assessed using the Cochrane Handbook tool. Thirteen studies were included. Most of the included studies employed periapical, near-infrared light transillumination, and bitewing radiography. The image databases ranged from 87 to 3000 images, with a mean of 669 images. Seven of the included studies labeled the dental caries in each image by experienced dentists. Not all of the studies detailed how caries was defined, and not all detailed the type of carious lesion detected. Each study included in this review used a different neural network and different outcome metrics. All this variability complicates the conclusions that can be made about the reliability or not of a neural network to detect and diagnose caries. A comparison between neural network and dentist results is also necessary. OI Prados-Privado, Maria/0000-0003-0833-0680; Prados Frutos, Juan Carlos/0000-0003-1464-0968 Z8 1 ZR 0 ZB 5 ZS 0 TC 34 ZA 0 Z9 36 C1 Asisa Dent, Res Dept, C Jose Abascal,32, Madrid 28003, Spain C1 Univ Alcala, Dept Signal Theory & Commun, Higher Polytech Sch, Km 33,600, Alcala De Henares 28805, Spain C1 Rey Juan Carlos Univ, IDIBO Grp, Grp High Performance Res Dev & Innovat Dent Bioma, Ave Atenas S-N, Alcorcon 28922, Spain C1 Univ Complutense Madrid, Fac Med, Plaza Ramon & Cajal,S-N, Madrid 28040, Spain C1 Univ Rey Juan Carlos, Fac Hlth Sci, Dept Med Specialties & Publ Hlth, Ave Atenas, Alcorcon 28922, Spain C3 Asisa Dent EI 2077-0383 DA 2020-12-10 UT WOS:000593158900001 PM 33172056 ER PT J AU Forouzeshfar, Parsa Safaei, Ali A. Ghaderi, Foad Kamangar, Sedighesadat Hashemi Kaviani, Hanieh Haghi, Sahebeh TI Dental caries diagnosis using neural networks and deep learning: a systematic review SO MULTIMEDIA TOOLS AND APPLICATIONS DI 10.1007/s11042-023-16599-w EA SEP 2023 DT Article; Early Access PY 2023 AB Dental caries is one of the oral health problems and the most common chronic infectious disease of childhood, and neural networks and artificial intelligence are increasingly being used in the field of dentistry. This review study aims to review studies published in the field of artificial intelligence and neural networks and dentistry. A search for studies in four databases, including Springer, ScienceDirect, PubMed (MedLine), and Institute of Electrical and Electronics Engineers (IEEE) was done. Finally, 28 studies were reviewed, most of which used Bitewing and Periapical images for the classification and detection of dental caries. The image databases ranged from 55 to 3000 and several evaluation metrics were used in the selected studies. The research questions were designed and reviewed based on PICOS (P stands for patient or problem, I stands for intervention, C stands for control or comparison, and O stands for outcomes). The majority of the studies also used pre-processing and data augmentation methods. The diversity between the networks used and the output evaluation criteria have made direct research comparisons challenging. The main focus of this research was on caries detection using deep learning methods and neural networks, especially convolutional neural networks that are suitable for images. The traditional methods of detecting caries, other than the methods based on artificial intelligence, have not been investigated in this research. Also, the main caries were interproximal and proximal caries in molars and premolars. The main difference between this and previous works is the use of more up-to-date articles (2016 to 2023) studies with an organized manner of reviewing, which is based on the types of images used. OI Safaei, Ali Asghar/0000-0003-1985-8720 ZR 0 Z8 0 ZB 0 ZA 0 ZS 0 TC 0 Z9 0 C1 Tarbiat Modares Univ, Fac Math Sci, Dept Data Sci, Tehran, Iran C1 Tarbiat Modares Univ, Fac Med Sci, Dept Med Informat, Tehran, Iran C1 Tarbiat Modares Univ, Fac Interdisciplinary Sci & Technol, Dept Data Sci, Tehran, Iran C1 Tarbiat Modares Univ, Elect & Comp Engn Dept, Human Comp Interact Lab, Tehran, Iran C1 Univ Tehran Med Sci, Dent Sch, Restorat Dept, Tehran, Iran C1 Univ Tehran Med Sci, Sch Dent, Dept Oral & Maxillofacial Radiol, Tehran, Iran C1 Univ Tehran Med Sci, Dent Sch, Dept Operat Dent, Tehran, Iran SN 1380-7501 EI 1573-7721 DA 2023-09-25 UT WOS:001060763900013 ER PT J AU Butcher, Mark C. Short, Bryn Veena, Chandra Lekha Ramalingam Bradshaw, Dave Pratten, Jonathan R. McLean, William Shaban, Suror Mohamad Ahmad Ramage, Gordon Delaney, Christopher TI Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes SO APMIS VL 130 IS 12 BP 763 EP 777 DI 10.1111/apm.13272 EA SEP 2022 DT Article PD DEC 2022 PY 2022 AB As one of the most prevalent infective diseases worldwide, it is crucial that we not only know the constituents of the oral microbiome in dental caries but also understand its functionality. Herein, we present a reproducible meta-analysis to effectively report the key components and the associated functional signature of the oral microbiome in dental caries. Publicly available sequencing data were downloaded from online repositories and subjected to a standardized analysis pipeline before analysis. Meta-analyses identified significant differences in alpha and beta diversities of carious microbiomes when compared to healthy ones. Additionally, machine learning and receiver operator characteristic analysis showed an ability to discriminate between healthy and disease microbiomes. We identified from importance values, as derived from random forest analyses, a group of genera, notably containing Selenomonas, Aggregatibacter, Actinomyces and Treponema, which can be predictive of dental caries. Finally, we propose the most appropriate study design for investigating the microbiome of dental caries by synthesizing the studies, which had the most accurate differentiation based on random forest modelling. In conclusion, we have developed a non-biased, reproducible pipeline, which can be applied to microbiome meta-analyses of multiple diseases, but importantly we have derived from our meta-analysis a key group of organisms that can be used to identify individuals at risk of developing dental caries based on oral microbiome inhabitants. RI Ramage, Gordon/JSK-1399-2023; Ramage, Gordon/AAX-1315-2020; Ramalingam Veena, Chandra Lekha/ OI Ramage, Gordon/0000-0002-0932-3514; Ramalingam Veena, Chandra Lekha/0000-0003-0487-9991 TC 3 ZR 0 Z8 0 ZA 0 ZB 1 ZS 0 Z9 3 C1 Univ Glasgow, Coll Med Vet & Life Sci, Oral Sci Res Grp, Glasgow Dent Sch,Sch Med Dent & Nursing, Glasgow, Lanark, Scotland C1 Haleon, R&D Innovat, Weybridge, Surrey, England C3 Haleon SN 0903-4641 EI 1600-0463 DA 2022-09-25 UT WOS:000855746800001 PM 36050830 ER PT J AU Moharrami, Mohammad Farmer, Julie Singhal, Sonica Watson, Erin Glogauer, Michael Johnson, Alistair E. W. Schwendicke, Falk Quinonez, Carlos TI Detecting dental caries on oral photographs using artificial intelligence: A systematic review SO ORAL DISEASES DI 10.1111/odi.14659 EA JUL 2023 DT Review; Early Access PY 2023 AB ObjectivesThis systematic review aimed at evaluating the performance of artificial intelligence (AI) models in detecting dental caries on oral photographs. MethodsMethodological characteristics and performance metrics of clinical studies reporting on deep learning and other machine learning algorithms were assessed. The risk of bias was evaluated using the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) tool. A systematic search was conducted in EMBASE, Medline, and Scopus. ResultsOut of 3410 identified records, 19 studies were included with six and seven studies having low risk of biases and applicability concerns for all the domains, respectively. Metrics varied widely and were assessed on multiple levels. F1-scores for classification and detection tasks were 68.3%-94.3% and 42.8%-95.4%, respectively. Irrespective of the task, F1-scores were 68.3%-95.4% for professional cameras, 78.8%-87.6%, for intraoral cameras, and 42.8%-80% for smartphone cameras. Limited studies allowed assessing AI performance for lesions of different severity. ConclusionAutomatic detection of dental caries using AI may provide objective verification of clinicians' diagnoses and facilitate patient-clinician communication and teledentistry. Future studies should consider more robust study designs, employ comparable and standardized metrics, and focus on the severity of caries lesions. RI Farmer, Julie/AAJ-8013-2021; Watson, Erin/ OI Farmer, Julie/0000-0001-5361-2180; Watson, Erin/0000-0002-2096-7732 ZR 0 Z8 0 ZS 0 ZA 0 ZB 0 TC 2 Z9 2 C1 Univ Toronto, Fac Dent, Toronto, ON, Canada C1 ITU WHO Focus Grp Hlth, Top Grp Dent Diagnost & Digital Dent, Geneva, Switzerland C1 Publ Hlth Ontario, Hlth Promot Chron Dis & Injury Prevent Dept, Toronto, ON, Canada C1 Princess Margaret Canc Ctr, Dept Dent Oncol, Toronto, ON, Canada C1 Mt Sinai Hosp, Ctr Adv Dent Res & Care, Dept Dent, Toronto, ON, Canada C1 Charite Univ Med Berlin, Oral Diagnost Digital Hlth & Hlth Serv Res, Berlin, Germany C1 Hosp Sick Children, Program Child Hlth Evaluat Sci, Toronto, ON, Canada C1 Western Univ, Schulich Sch Med & Dent, London, ON, Canada C1 Univ Toronto, Fac Dent, 124 Edward St, Toronto, ON M5G 1X5, Canada C3 ITU WHO Focus Grp Hlth C3 Publ Hlth Ontario SN 1354-523X EI 1601-0825 DA 2023-07-08 UT WOS:001017636400001 PM 37392423 ER PT J AU Khanagar, Sanjeev B. Al-ehaideb, Ali Maganur, Prabhadevi C. Vishwanathaiah, Satish Patil, Shankargouda Baeshen, Hosam A. Sarode, Sachin C. Bhandi, Shilpa TI Developments, application, and performance of artificial intelligence in dentistry - A systematic review SO JOURNAL OF DENTAL SCIENCES VL 16 IS 1 BP 508 EP 522 DI 10.1016/j.jds.2020.06.019 DT Review PD JAN 2021 PY 2021 AB Background/purpose: Artificial intelligence (AI) has made deep inroads into dentistry in the last few years. The aim of this systematic review was to identify the development of AI applications that are widely employed in dentistry and evaluate their performance in terms of diagnosis, clinical decision-making, and predicting the prognosis of the treatment. Materials and methods: The literature for this paper was identified and selected by perform-ing a thorough search in the electronic data bases like PubMed, Medline, Embase, Cochrane, Google scholar, Scopus, Web of science, and Saudi digital library published over the past two decades (January 2000eMarch 15, 2020).After applying inclusion and exclusion criteria, 43 articles were read in full and critically analyzed. Quality analysis was performed using QUA-DAS-2. Results: AI technologies are widely implemented in a wide range of dentistry specialties. Most of the documented work is focused on AI models that rely on convolutional neural net-works (CNNs) and artificial neural networks (ANNs). These AI models have been used in detec-tion and diagnosis of dental caries, vertical root fractures, apical lesions, salivary gland diseases, maxillary sinusitis, maxillofacial cysts, cervical lymph nodes metastasis, osteopo-rosis, cancerous lesions, alveolar bone loss, predicting orthodontic extractions, need for or-thodontic treatments, cephalometric analysis, age and gender determination. Conclusion: These studies indicate that the performance of an AI based automated system is excellent. They mimic the precision and accuracy of trained specialists, in some studies it was found that these systems were even able to outmatch dental specialists in terms of per-formance and accuracy. (C) 2020 Association for Dental Sciences of the Republic of China. Publishing services by Else-vier B.V. RI Vishwanathaiah, Satish/AAD-5770-2021; Sarode, Sachin/I-5048-2014; Patil, shankargouda/GWC-7516-2022; Patil, Shankargouda/G-5256-2013; KHANAGAR, SANJEEV/ OI Vishwanathaiah, Satish/0000-0002-8376-297X; Sarode, Sachin/0000-0003-1856-0957; Patil, shankargouda/0000-0001-7246-5497; KHANAGAR, SANJEEV/0000-0002-4098-7773 ZS 1 ZA 0 ZR 0 TC 132 ZB 14 Z8 6 Z9 141 C1 King Saud Bin Abdulaziz Univ Hlth Sci, Coll Dent, Prevent Dent Sci Dept, Riyadh, Saudi Arabia C1 King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia C1 Minist Natl Guard Hlth Affairs, King Abdulaziz Med City, Dent Serv, Riyadh, Saudi Arabia C1 Jazan Univ, Dept Prevent Dent Sci, Div Pedodont, Coll Dent, Jazan, Saudi Arabia C1 Jazan Univ, Dept Maxillofacial Surg & Diagnost Sci, Div Oral Pathol, Coll Dent, Jazan, Saudi Arabia C1 King Abdulaziz Univ, Coll Dent, Dept Orthodont, Orthodont, Jeddah, Saudi Arabia C1 Dr DY Patil Vidyapeeth, Dr DY Patil Dent Coll & Hosp, Dept Oral & Maxillofacial Pathol, Pune 411018, Maharashtra, India C1 Jazan Univ, Dept Restorat Dent Sci, Div Operat Dent, Coll Dent, Jazan, Saudi Arabia SN 1991-7902 EI 2213-8862 DA 2021-01-01 UT WOS:000604780000026 PM 33384840 ER PT J AU Alqutaibi, Ahmed Yaseen Aboalrejal, Afaf Noman TI ARTIFICIAL INTELLIGENCE (AI) AS AN AID IN RESTORATIVE DENTISTRY IS PROMISING, BUT STILL A WORK IN PROGRESS SO JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE VL 23 IS 1 AR 101837 DI 10.1016/j.jebdp.2023.101837 EA MAR 2023 DT Article PD MAR 2023 PY 2023 AB Selection Criteria Besides manual search, an electronic search was conducted in 5 databases: MED-LINE, Web of Science, EMBASE, Scopus, and Cochrane. The eligibility crite-ria included clinical and in vitro studies that evaluated the diagnostic perfor-mance of artificial intelligence (AI) models in restorative dentistry to detect dental caries and vertical tooth fractures, identify tooth preparation margins, and pre-dict restoration failure. On the other hand, letters to editors, studies related to robotics in dentistry, radiographic enhancement investigations, and age estima-tion model studies were excluded. Two reviewers independently screened the title and abstract, performed data ex-traction, and assessed the risk of bias in relevant articles; the discussion with the third reviewer addressed any disagreement. The Joanna Briggs Institute JBI Crit-ical Appraisal Checklist for Quasi-Experimental Evaluation was used to appraise included studies critically for their quality. Key Study Factor A review of studies in the field of restorative dentistry that developed AI models for detecting dental caries (no = 29), vertical tooth fracture (no = 2), or the tooth finishing line (no = 1), besides studies of AI models that predict restoration failure (no = 2), were evaluated. Main Outcome Measure The diagnostic accuracy based on the sensitivity and specificity of AI models as a tool for detecting dental caries, vertical tooth fracture, the tooth finishing line, and predicting restoration failure. RI Alqutaibi, Ahmed Yaseen/AAG-4872-2020 OI Alqutaibi, Ahmed Yaseen/0000-0001-6536-8269 ZA 0 ZB 0 Z8 0 ZS 0 ZR 0 TC 1 Z9 1 C1 Taibah Univ, Coll Dent, Dept Prosthodont & Implant Dent, Medina, Saudi Arabia C1 Ibb Univ, Coll Dent, Dept Prosthodont, Ibb, Yemen C1 Ibb Univ, Fac Oral & Dent Med, Dept Oral Biol, Ibb, Yemen C3 Ibb Univ C3 Ibb Univ SN 1532-3382 EI 1532-3390 DA 2023-04-07 UT WOS:000955195300001 PM 36914305 ER PT J AU Musri, Nabilla Christie, Brenda Ichwan, Solachuddin Jauhari Arief Cahyanto, Arief TI Deep learning convolutional neural network algorithms for the early detection and diagnosis of dental caries on periapical radiographs: A systematic review. SO Imaging science in dentistry VL 51 IS 3 BP 237 EP 242 DI 10.5624/isd.20210074 DT Journal Article PD 2021-Sep PY 2021 AB PURPOSE: The aim of this study was to analyse and review deep learning convolutional neural networks for detecting and diagnosing early-stage dental caries on periapical radiographs. MATERIALS AND METHODS: In order to conduct this review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Studies published from 2015 to 2021 under the keywords (deep convolutional neural network) AND (caries), (deep learning caries) AND (convolutional neural network) AND (caries) were systematically reviewed. RESULTS: When dental caries is improperly diagnosed, the lesion may eventually invade the enamel, dentin, and pulp tissue, leading to loss of tooth function. Rapid and precise detection and diagnosis are vital for implementing appropriate prevention and treatment of dental caries. Radiography and intraoral images are considered to play a vital role in detecting dental caries; nevertheless, studies have shown that 20% of suspicious areas are mistakenly diagnosed as dental caries using this technique; hence, diagnosis via radiography alone without an objective assessment is inaccurate. Identifying caries with a deep convolutional neural network-based detector enables the operator to distinguish changes in the location and morphological features of dental caries lesions. Deep learning algorithms have broader and more profound layers and are continually being developed, remarkably enhancing their precision in detecting and segmenting objects. CONCLUSION: Clinical applications of deep learning convolutional neural networks in the dental field have shown significant accuracy in detecting and diagnosing dental caries, and these models hold promise in supporting dental practitioners to improve patient outcomes. RI Cahyanto, Arief/L-2410-2016; Musri, Nabilla/; Christie, Brenda/ OI Cahyanto, Arief/0000-0003-2222-5895; Musri, Nabilla/0000-0003-0559-6571; Christie, Brenda/0000-0002-4321-9518 Z8 0 ZA 0 ZR 0 ZB 0 ZS 0 TC 6 Z9 7 C1 Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia. C1 Faculty of Dentistry, International Islamic University Malaysia, Kuantan, Malaysia. C1 Department of Dental Materials Science and Technology, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia. C1 Oral Biomaterials Study Centre, Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia. C1 Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. SN 2233-7822 DA 2021-10-29 UT MEDLINE:34621650 PM 34621650 ER PT J AU Hegde, Shwetha Gao, Jinlong TI DEEP LEARNING ALGORITHMS SHOW SOME POTENTIAL AS AN ADJUNCTIVE TOOL IN CARIES DIAGNOSIS SO JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE VL 22 IS 4 AR 101772 DI 10.1016/j.jebdp.2022.101772 EA DEC 2022 DT Editorial Material PD DEC 2022 PY 2022 OI Gao, Jinlong/0000-0002-5153-5393 Z8 0 ZS 0 TC 0 ZR 0 ZB 0 ZA 0 Z9 0 C1 Univ Sydney, Sydney Dent Sch, Dentomaxillofacial Radiol, Chalmers St, Surry Hills, NSW 2010, Australia C1 Univ Sydney, Fac Med & Hlth, Sydney Dent Sch, Chalmers St, Surry Hills, NSW 2010, Australia SN 1532-3382 EI 1532-3390 DA 2023-01-15 UT WOS:000899822800010 PM 36494110 ER PT J AU Singh, Nripendra Kumar Raza, Khalid TI Progress in deep learning-based dental and maxillofacial image analysis: A systematic review SO EXPERT SYSTEMS WITH APPLICATIONS VL 199 AR 116968 DI 10.1016/j.eswa.2022.116968 EA MAR 2022 DT Review PD AUG 1 2022 PY 2022 AB Background: With the advent of deep learning in modern computing there has been unprecedented progress in image processing and segmentation. Deep learning-based image pattern recognition achieved a significant place in interpreting dental radiographs towards automatic diagnosis and treatment. In context with dental imaging, deep learning-based image analysis has been able to perform dental structure segmentation, classification, and identification of several common dental diseases with significant 90% accuracy. These results open a window of hope for better diagnosis and treatment planning in dental medicine. This review systematically presents recent advances in deep learning-based dental and maxillofacial image analysis. Materials and methods: We performed an extensive literature survey using the PubMed literature repository for identifying suitable articles. We shortlisted more than 75 articles that use deep learning for dental image seg-mentation, object detection, classification, and other image processing-related tasks. This study includes vari-ables such as the size of the dataset, dental imaging modality, deep learning architecture, and performance evaluation measures. Results: We have summarized recent developments and a concise overview of studies on various applications of dental and maxillofacial image analysis. We primarily discussed how deep learning techniques have been exploited in areas such as tooth detection and labeling, dental caries, plaque, periodontal condition, osteoporosis, oral lesion, anatomical landmarking, age, and gender estimation. The challenges and future research directions in the area have been extensively discussed. Conclusion: Undoubtedly remarkable progress is witnessed in dental image analysis in recent years. However, many crucial aspects still need to be addressed including standardization of data and generalization in AI-based solutions towards dental and maxillofacial image analysis for the diagnosis and better treatment aid in the field of dentistry which will open a new avenue in dental clinical practices. RI Kumar Singh, Nripendra/GWQ-3806-2022; Raza, Khalid/I-4931-2012; Singh, Nripendra Kumar/ OI Raza, Khalid/0000-0002-3646-6828; Singh, Nripendra Kumar/0000-0002-4531-9985 ZS 0 ZR 0 ZB 1 TC 12 ZA 0 Z8 0 Z9 12 C1 Jamia Millia Islamia, Dept Comp Sci, New Delhi 110025, India SN 0957-4174 EI 1873-6793 DA 2022-06-10 UT WOS:000793149000009 ER PT J AU Reyes, Lilian Toledo Knorst, Jessica Klockner Ortiz, Fernanda Ruffo Ardenghi, Thiago Machado TI Machine Learning in the Diagnosis and Prognostic Prediction of Dental Caries: A Systematic Review SO CARIES RESEARCH VL 56 IS 3 BP 161 EP 170 DI 10.1159/000524167 DT Review PD NOV 2022 PY 2022 AB We performed a systematic review to evaluate the success of machine learning algorithms in the diagnosis and prognostic prediction of dental caries. The review protocol was a priori registered in the PROSPERO, CRD42020183447. The search involved electronic bibliographic databases: PubMed/Medline, Scopus, EMBASE, Web of Science, and grey literature until December 2020. We excluded review articles, case series, case reports, editorials, letters, comments, educational methodologies, assessments of robotic devices, and articles with less than 10 participants or specimens. Two independent reviewers selected the studies and performed the assessment of the methodological quality based on standardized scales. We summarize data on the machine learning algorithms used; software; performance outcomes such as accuracy/precision, sensitivity/recall, specificity, area under the receiver operating characteristic curve (AUC), and positive/negative predictive values related to dental caries. Meta-analyses were not performed due to methodological differences. Our review included 15 studies (10 diagnostic studies and 5 prognostic prediction studies). Cross-sectional design studies were predominant (12). The most frequently used statistical measure of performance reported in diagnostic studies was AUC value, which ranged from 0.745 to 0.987. For most diagnostic studies, data from contingency tables were not available. Reported sensitivities were higher in low risk of bias prognostic prediction studies (median [IQR] of 0.996 [0.971-1.000] vs. unclear/high risk of bias studies 0.189 [0-0.340]; p value 0.025). While there were no significant differences in the specificity between these subgroups, we concluded that the use of these technologies for the diagnosis and prognostic prediction of dental caries, although promising, is at an early stage. The general applicability of the evidence was limited given that most models were developed outside the real clinical setting with a prevalence of unclear/high risk of bias. Researchers must increase the overall quality of their research protocols by providing a comprehensive report on the methods implemented. (C) 2022 S. Karger AG, Basel RI Knorst, Jessica/V-4640-2019; Ortiz, Fernanda Ruffo/O-2557-2016; ARDENGHI, THIAGO/ OI Knorst, Jessica/0000-0001-7792-8032; Ortiz, Fernanda Ruffo/0000-0003-0759-9661; ARDENGHI, THIAGO/0000-0002-5109-740X ZR 0 TC 3 ZA 0 ZS 0 Z8 0 ZB 1 Z9 3 C1 Univ Fed Santa Maria, Sch Dent, Dept Stomatol, Santa Maria, Brazil SN 0008-6568 EI 1421-976X DA 2022-12-06 UT WOS:000888852800003 PM 35636386 ER PT J AU Dhiman, Poonam Kaur, Amandeep Balasaraswathi, V. R. Gulzar, Yonis Alwan, Ali A. Hamid, Yasir TI Image Acquisition, Preprocessing and Classification of Citrus Fruit Diseases: A Systematic Literature Review SO SUSTAINABILITY VL 15 IS 12 AR 9643 DI 10.3390/su15129643 DT Review PD JUN 2023 PY 2023 AB Different kinds of techniques are evaluated and analyzed for various classification models for the detection of diseases of citrus fruits. This paper aims to systematically review the papers that focus on the prediction, detection, and classification of citrus fruit diseases that have employed machine learning, deep learning, and statistical techniques. Additionally, this paper explores the present state of the art of the concept of image acquisition, digital image processing, feature extraction, and classification approaches, and each one is discussed separately. A total of 78 papers are selected after applying primary selection criteria, inclusion/exclusion criteria, and quality assessment criteria. We observe that the following are widely used in the selected studies: hyperspectral imaging systems for the image acquisition process, thresholding for image processing, support vector machine (SVM) models as machine learning (ML) models, convolutional neural network (CNN) architectures as deep learning models, principal component analysis (PCA) as a statistical model, and classification accuracy as evaluation parameters. Moreover, the color feature is the most popularly used feature for the RGB color space. From the review studies that performed comparative analyses, we find that the best techniques that outperformed other techniques in their respective categories are as follows: SVM among the ML methods, ANN among the neural network networks, CNN among the deep learning methods, and linear discriminant analysis (LDA) among the statistical techniques.This study concludes with meta-analysis, limitations, and future research directions. RI Gulzar, Yonis/X-6394-2019; Kaur, Amandeep/IYJ-2622-2023; hamid, yasir/; ALWAN, ALI/; Kaur, Amandeep/ OI Gulzar, Yonis/0000-0002-6515-1569; Kaur, Amandeep/0000-0002-9825-4951; hamid, yasir/0000-0003-1334-2651; ALWAN, ALI/0000-0003-3279-9366; Kaur, Amandeep/0000-0002-7282-8902 ZB 2 Z8 0 ZR 0 ZS 0 ZA 0 TC 12 Z9 12 C1 Govt PG Coll, Dept Higher Educ, Ambala 133001, India C1 Chitkara Univ, Inst Engn & Technol, Rajpura 713104, Punjab, India C1 SRM Inst Sci & Technol, Sch Comp, Dept Networking & Commun, Kattankullattur 462003, India C1 King Faisal Univ, Coll Business Adm, Dept Management Informat Syst, Al Hasa 31982, Saudi Arabia C1 Ramapo Coll, Sch Theoret, Mahwah, NJ 07430 USA C1 Ramapo Coll, Sch Appl Sci, Mahwah, NJ 07430 USA C1 Abu Dhabi Polytech, Dept Informat Secur & Engn Technol, Abu Dhabi 111499, U Arab Emirates C3 Govt PG Coll C3 SRM Inst Sci & Technol C3 Abu Dhabi Polytech EI 2071-1050 DA 2023-07-07 UT WOS:001015801500001 ER PT J AU Khanagar, Sanjeev Balappa Alfouzan, Khalid Alkadi, Lubna Albalawi, Farraj Iyer, Kiran Awawdeh, Mohammed TI Performance of Artificial Intelligence (AI) Models Designed for Application in Pediatric Dentistry-A Systematic Review SO APPLIED SCIENCES-BASEL VL 12 IS 19 AR 9819 DI 10.3390/app12199819 DT Review PD OCT 2022 PY 2022 AB Oral diseases are the most prevalent chronic childhood diseases, presenting as a major public health issue affecting children of all ages in the developing and developed countries. Early detection and control of these diseases is very crucial for a child's oral health and general wellbeing. The aim of this systematic review is to assess the performance of artificial intelligence models designed for application in pediatric dentistry. A systematic search of the literature was conducted using different electronic databases, primarily (PubMed, Scopus, Web of Science, Embase, Cochrane) and secondarily (Google Scholar and the Saudi Digital Library) for studies published from 1 January 2000, until 20 July 2022, related to the research topic. The quality of the twenty articles that satisfied the eligibility criteria were critically analyzed based on the QUADAS-2 guidelines. Artificial intelligence models have been utilized for the detection of plaque on primary teeth, prediction of children's oral health status (OHS) and treatment needs (TN); detection, classification and prediction of dental caries; detection and categorization of fissure sealants; determination of the chronological age; determination of the impact of oral health on adolescent's quality of life; automated detection and charting of teeth; and automated detection and classification of mesiodens and supernumerary teeth in primary or mixed dentition. Artificial intelligence has been widely applied in pediatric dentistry in order to help less-experienced clinicians in making more accurate diagnoses. These models are very efficient in identifying and categorizing children into various risk groups at the individual and community levels. They also aid in developing preventive strategies, including designing oral hygiene practices and adopting healthy eating habits for individuals. RI Iyer, Kiran/AAS-7076-2021; awawdeh, mohammed/HOC-0358-2023; Alkadi, Lubna/; KHANAGAR, SANJEEV/ OI Iyer, Kiran/0000-0003-3551-870X; Alkadi, Lubna/0000-0003-3206-8547; KHANAGAR, SANJEEV/0000-0002-4098-7773 ZS 0 TC 0 ZA 0 Z8 0 ZR 0 ZB 0 Z9 0 C1 King Saud Bin Abdulaziz Univ Hlth Sci, Coll Dent, Prevent Dent Sci Dept, Riyadh 11426, Saudi Arabia C1 Minist Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Riyadh 11481, Saudi Arabia C1 King Saud Bin Abdulaziz Univ Hlth Sci, Coll Dent, Restorat & Prosthet Dent Sci Dept, Riyadh 11426, Saudi Arabia EI 2076-3417 DA 2022-10-20 UT WOS:000866659600001 ER PT J AU Khanagar, Sanjeev B. Alfouzan, Khalid Awawdeh, Mohammed Alkadi, Lubna Albalawi, Farraj Alfadley, Abdulmohsen TI Application and Performance of Artificial Intelligence Technology in Detection, Diagnosis and Prediction of Dental Caries (DC)-A Systematic Review SO DIAGNOSTICS VL 12 IS 5 AR 1083 DI 10.3390/diagnostics12051083 DT Review PD MAY 2022 PY 2022 AB Evolution in the fields of science and technology has led to the development of newer applications based on Artificial Intelligence (AI) technology that have been widely used in medical sciences. AI-technology has been employed in a wide range of applications related to the diagnosis of oral diseases that have demonstrated phenomenal precision and accuracy in their performance. The aim of this systematic review is to report on the diagnostic accuracy and performance of AI-based models designed for detection, diagnosis, and prediction of dental caries (DC). Eminent electronic databases (PubMed, Google scholar, Scopus, Web of science, Embase, Cochrane, Saudi Digital Library) were searched for relevant articles that were published from January 2000 until February 2022. A total of 34 articles that met the selection criteria were critically analyzed based on QUADAS-2 guidelines. The certainty of the evidence of the included studies was assessed using the GRADE approach. AI has been widely applied for prediction of DC, for detection and diagnosis of DC and for classification of DC. These models have demonstrated excellent performance and can be used in clinical practice for enhancing the diagnostic performance, treatment quality and patient outcome and can also be applied to identify patients with a higher risk of developing DC. RI Alfadley, Abdulmohsen/JCO-4622-2023; awawdeh, mohammed/HOC-0358-2023; Alfadley, Abdulmohsen/; Alkadi, Lubna/; KHANAGAR, SANJEEV/ OI Alfadley, Abdulmohsen/0000-0002-5868-034X; Alkadi, Lubna/0000-0003-3206-8547; KHANAGAR, SANJEEV/0000-0002-4098-7773 TC 8 Z8 0 ZB 0 ZS 0 ZA 0 ZR 0 Z9 8 C1 King Saud bin Abdulaziz Univ Hlth Sci, Prevent Dent Sci Dept, Coll Dent, Riyadh 11426, Saudi Arabia C1 King Abdullah Int Med Res Ctr, Minist Natl Guard Hlth Affairs, Riyadh 11481, Saudi Arabia C1 King Saud bin Abdulaziz Univ Hlth Sci, Restorat & Prosthet Dent Sci Dept, Coll Dent, Riyadh 11426, Saudi Arabia EI 2075-4418 DA 2022-06-09 UT WOS:000803406500001 PM 35626239 ER PT J AU Revilla-Leon, Marta Gomez-Polo, Miguel Vyas, Shantanu Barmak, Abdul Basir Ozcan, Mutlu Att, Wael Krishnamurthy, Vinayak R. TI Artificial intelligence applications in restorative dentistry: A systematic review SO JOURNAL OF PROSTHETIC DENTISTRY VL 128 IS 5 BP 867 EP 875 DI 10.1016/j.prosdent.2021.02.010 EA NOV 2022 DT Review PD NOV 2022 PY 2022 AB Statement of problem. Artificial intelligence (AI) applications are increasing in restorative procedures. However, the current development and performance of AI in restorative dentistry applications has not yet been systematically documented and analyzed.Purpose. The purpose of this systematic review was to identify and evaluate the ability of AI models in restorative dentistry to diagnose dental caries and vertical tooth fracture, detect tooth preparation margins, and predict restoration failure.Material and methods. An electronic systematic review was performed in 5 databases: MEDLINE/ PubMed, EMBASE, World of Science, Cochrane, and Scopus. A manual search was also conducted. Studies with AI models were selected based on 4 criteria: diagnosis of dental caries, diagnosis of vertical tooth fracture, detection of the tooth preparation finishing line, and prediction of restoration failure. Two investigators independently evaluated the quality assessment of the studies by applying the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Quasi-Experimental Studies (nonrandomized experimental studies). A third investigator was consulted to resolve lack of consensus.Results. A total of 34 articles were included in the review: 29 studies included AI techniques for the diagnosis of dental caries or the elaboration of caries and postsensitivity prediction models, 2 for the diagnosis of vertical tooth fracture, 1 for the tooth preparation finishing line location, and 2 for the prediction of the restoration failure. Among the studies reviewed, the AI models tested obtained a caries diagnosis accuracy ranging from 76% to 88.3%, sensitivity ranging from 73% to 90%, and specificity ranging from 61.5% to 93%. The caries prediction accuracy among the studies ranged from 83.6% to 97.1%. The studies reported an accuracy for the vertical tooth fracture diagnosis ranging from 88.3% to 95.7%. The article using AI models to locate the finishing line reported an accuracy ranging from 90.6% to 97.4%.Conclusions. AI models have the potential to provide a powerful tool for assisting in the diagnosis of caries and vertical tooth fracture, detecting the tooth preparation margin, and predicting restoration failure. However, the dental applications of AI models are still in development. Further studies are required to assess the clinical performance of AI models in restorative dentistry. (J Prosthet Dent 2022;128:867-75) RI Revilla-León, Marta/AAH-2117-2019; BARMAK, ABDUL BASIR/; Att, Wael/; Vyas, Shantanu/; Gomez-Polo, Miguel/ OI Revilla-León, Marta/0000-0003-2854-1135; BARMAK, ABDUL BASIR/0000-0002-7067-9712; Att, Wael/0000-0002-4879-0895; Vyas, Shantanu/0000-0003-2314-2821; Gomez-Polo, Miguel/0000-0001-8614-8484 ZA 0 ZS 0 ZB 1 ZR 0 TC 22 Z8 1 Z9 23 C1 Texas A&M Univ, Coll Dent, Dept Comprehens Dent, Dallas, TX USA C1 Univ Washington, Affiliate Fac Grad Prosthodont, Sch Dent, Dept Restorat Dent, Seattle, WA USA C1 Revilla Res Ctr, Madrid, Spain C1 Univ Complutense Madrid, Sch Dent, Dept Conservat Dent & Prosthodont, Ramon y Cajal S-N, Madrid 28040, Spain C1 Texas A&M Univ, J Mike Walker Dept Mech Engn 66, Dallas, TX USA C1 Univ Rochester, Eastman Inst Oral Hlth, Clin Res & Biostat, Med Ctr, Rochester, NY USA C1 Univ Zurich, Ctr Dent & Oral Med, Div Dent Biomat, Clin Reconstruct Dent, Zurich, Switzerland C1 Tufts Univ, Dept Prosthodont, Sch Dent Med, Boston, MA USA C1 Texas A&M Univ, J Mike Walker Dept Mech Engn 66, College Stn, TX USA C3 Revilla Res Ctr SN 0022-3913 EI 1097-6841 DA 2023-01-06 UT WOS:000892488100007 PM 33840515 ER PT J AU Goel, Lavika Nagpal, Jyoti TI A Systematic Review of Recent Machine Learning Techniques for Plant Disease Identification and Classification SO IETE TECHNICAL REVIEW VL 40 IS 3 BP 423 EP 439 DI 10.1080/02564602.2022.2121772 EA SEP 2022 DT Review PD MAY 4 2023 PY 2023 AB Plant disease management in agriculture science is the primary concern for every country, as the food demand is increasing fast due to an increase in population. Furthermore, modern technology has improved the efficacy and precision of disease detection in plants and animals. Plant disease identification using various image processing approaches has recently been employed on a big scale to help farmers monitor their plantation areas. Based on the perpetuation and spread, the diseases can be floral, foliar, and soilborne. Grain production is typically affected by foliar diseases, which reduce photosynthetic area, duration, and function. Soil-borne conditions include vascular wilt, root rot, and damping-off; and can exhibit symptoms such as wilting of foliage, root decay, and sudden death. This paper highlights the significant issues and challenges for leaf disease classification. A comparative study of different methods based on the agricultural product, methodology, efficiency, advantages, and disadvantages is also included. The review study analyzes the most frequently used machine learning algorithms in the last five to seven years, revealing that Support Vector Machine (SVM) has been extensively used for disease classification. An analysis of specific Techniques (Feature Extraction plus machine learning-based Classification algorithm) and their associated accuracy is also performed, demonstrating that (ORB) features combined with Linear SVM provide the highest accuracy of 99.98%. OI Goel, Lavika/0000-0002-3200-2604 ZB 0 ZS 0 Z8 0 TC 0 ZR 0 ZA 0 Z9 0 C1 Malaviya Natl Inst Technol, Jaipur, Rajasthan, India SN 0256-4602 EI 0974-5971 DA 2022-09-30 UT WOS:000857333100001 ER PT J AU Bentsen, Niclas Scott TI Carbon debt and payback time - Lost in the forest? SO RENEWABLE & SUSTAINABLE ENERGY REVIEWS VL 73 BP 1211 EP 1217 DI 10.1016/j.rser.2017.02.004 DT Review PD JUN 2017 PY 2017 AB In later years the potential contribution of forest bioenergy to mitigate climate change has been increasingly questioned due to temporal displacement between CO2 emissions when forest biomass is used for energy and subsequent sequestration of carbon in new biomass. Also disturbance of natural decay of dead biomass when used for energy affect the carbon dynamics of forest ecosystems. These perturbations of forest ecosystems are summarized under the concept of carbon debt and its payback time. Narrative reviews demonstrate that the payback time of apparently comparable forest bioenergy supply scenarios vary by up to 200 years allowing amble room for confusion and dispute about the climate benefits of forest bioenergy. This meta-analysis confirm that the outcome of carbon debt studies lie in the assumptions and find that methodological rather than ecosystem and management related assumptions determine the findings. The study implies that at the current development of carbon debt methodologies and their lack of consensus the concept in it-self is inadequate for informing and guiding policy development. At the management level the carbon debt concept may provide valuable information directing management principles in a more climate benign directions. RI Bentsen, Niclas Scott/E-4766-2010 OI Bentsen, Niclas Scott/0000-0002-5130-0818 TC 41 Z8 1 ZS 0 ZA 0 ZR 0 ZB 17 Z9 42 C1 Univ Copenhagen, Fac Sci, Dept Geosci & Nat Resource Management, Rolighedsvej 23, DK-1958 Frederiksberg C, Denmark SN 1364-0321 DA 2017-05-31 UT WOS:000401204700091 ER PT J AU Olajide, Olufemi Olatunde Z2 TI Developing Caries Inequalities Risk Prediction Tools for Children Under the Age of Six DT Dissertation/Thesis PD Jan 01 2019 PY 2019 ZA 0 ZR 0 ZS 0 Z8 0 TC 0 ZB 0 Z9 0 C1 University of Central Lancashire (United Kingdom), England C3 University of Central Lancashire (United Kingdom) UT PQDT:66949609 ER PT J AU Agarwal, Vikram Kelley, David R. TI The genetic and biochemical determinants of mRNA degradation rates in mammals SO GENOME BIOLOGY VL 23 IS 1 AR 245 DI 10.1186/s13059-022-02811-x DT Article PD NOV 23 2022 PY 2022 AB Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors governing it remain poorly characterized. Understanding the genetic and biochemical determinants of mRNA half-life would enable more precise identification of variants that perturb gene expression through post-transcriptional gene regulatory mechanisms. Results We establish a compendium of 39 human and 27 mouse transcriptome-wide mRNA decay rate datasets. A meta-analysis of these data identified a prevalence of technical noise and measurement bias, induced partially by the underlying experimental strategy. Correcting for these biases allowed us to derive more precise, consensus measurements of half-life which exhibit enhanced consistency between species. We trained substantially improved statistical models based upon genetic and biochemical features to better predict half-life and characterize the factors molding it. Our state-of-the-art model, Saluki, is a hybrid convolutional and recurrent deep neural network which relies only upon an mRNA sequence annotated with coding frame and splice sites to predict half-life (r=0.77). The key novel principle learned by Saluki is that the spatial positioning of splice sites, codons, and RNA-binding motifs within an mRNA is strongly associated with mRNA half-life. Saluki predicts the impact of RNA sequences and genetic mutations therein on mRNA stability, in agreement with functional measurements derived from massively parallel reporter assays. Conclusions Our work produces a more robust ground truth for transcriptome-wide mRNA half-lives in mammalian cells. Using these revised measurements, we trained Saluki, a model that is over 50% more accurate in predicting half-life from sequence than existing models. Saluki succinctly captures many of the known determinants of mRNA half-life and can be rapidly deployed to predict the functional consequences of arbitrary mutations in the transcriptome. ZR 0 ZA 0 ZB 5 ZS 0 TC 9 Z8 0 Z9 10 C1 Calico Life Sci LLC, San Francisco, CA 94080 USA C1 Sanofi Pasteur Inc, mRNA Ctr Excellence, Waltham, MA 02451 USA C3 Calico Life Sci LLC C3 Sanofi Pasteur Inc SN 1474-760X DA 2022-12-04 UT WOS:000886995500001 PM 36419176 ER PT J AU Oishi, Wakana Sano, Daisuke TI Estimation of alkali dosage and contact time for treating human excreta containing viruses as an emergency response: a systematic review SO FRONTIERS IN PUBLIC HEALTH VL 11 AR 1286595 DI 10.3389/fpubh.2023.1286595 DT Review PD NOV 10 2023 PY 2023 AB Water, sanitation, and hygiene provisions are essential during emergencies to prevent infectious disease outbreaks caused by improper human excreta management in settlements for people affected by natural disasters and conflicts. Human excreta disinfection is required when long-term containment in latrines is not feasible on-site. Alkali additives, including lime, are effective disinfectants for wastewater and faecal sludge containing large amounts of solid and dissolved organic matter. The aim of this study was to determine the minimum dose and contact time of alkali additives for treating virus-containing human excreta in emergency situations. We used literature data collected by searching Google Scholar and Web of Science. The date of the last search for each study was 31th May 2023. Only peer-reviewed articles that included disinfection practices in combination with quantitative data for the physicochemical data of a matrix and viral decay were selected for data extraction. Two reviewers independently collected data from each study. We extracted datasets from 14 studies that reported quantitative information about their disinfection tests, including viral decay over time, matrix types, and physicochemical properties. Three machine learning algorithms were applied to the collected dataset to determine the time required to achieve specified levels of virus inactivation under different environmental conditions. The best model was used to estimate the contact time to achieve a 3-log10 inactivation of RNA virus in wastewater and faeces. The most important variables for predicting the contact time were pH, temperature, and virus type. The estimated contact time for 3 log inactivation of RNA virus was <2 h at pH 12, which was achieved by adding 1.8 and 3.1% slaked lime to wastewater and faeces, respectively. The contact time decreased exponentially with the pH of the sludge and wastewater. In contrast, the pH of the sludge and wastewater increased linearly with the slaked lime dosage. Lime treatment is a promising measure where long-term containment in latrine is not feasible in densely populated areas, as 1 day is sufficient to inactivate viruses. The relationship we have identified between required contact time and lime dosage is useful for practitioners in determining appropriate treatment conditions of human waste. RI Sano, Daisuke/E-5819-2011 OI Sano, Daisuke/0000-0001-8075-6972 TC 0 Z8 0 ZA 0 ZS 0 ZB 0 ZR 0 Z9 0 C1 Tohoku Univ, Grad Sch Engn, Dept Civil & Environm Engn, Sendai, Miyagi, Japan C1 Tohoku Univ, Grad Sch Environm Studies, Dept Frontier Sci Adv Environm, Sendai, Japan EI 2296-2565 DA 2023-12-12 UT WOS:001107273000001 PM 38026419 ER EF