drug_name,drug_id,drug_target,target_pathway,feature_name,n_feature_pos,n_feature_neg,ic50_effect_size,log_ic50_mean_pos,log_ic50_mean_neg,log_max_conc_tested,log_max_conc_tested_2,feature_ic50_t_pval,feature_delta_mean_ic50,feature_pos_ic50_var,feature_neg_ic50_var,feature_pval,tissue_pval,msi_pval,fdr,tissue_type,screening set
IC-87114,236,PI3Kdelta,PI3K/MTOR signaling,cnaPRAD7,3,3,.77954995438089125,5.3334217955306968,4.9153844138863994,,,.39735280664831685,.41803738164429749,.45897051581587467,.60372545310901482,.47903171935190375,,.8526257436284278,0,PRAD,GDSC1
ACY-1215,264,HDAC6,Chromatin histone acetylation,cnaPRAD7,3,3,.7772700840063077,1.1331480803494123,1.4583164944648181,,,.39502857850124928,-.32516841411540587,.42004381691712361,.41664277220505019,.29487907400160746,,.54563805115948816,0,PRAD,GDSC1
JNJ38877605,284,MET,RTK signaling,cnaPRAD7,3,3,.044833706743027217,4.3238443660163108,4.3595881747313152,,,.95885418545675516,-.035743808715004377,.77072421241864941,.82292708548778937,.78110513070020315,,.3799652804969374,99.928871980476643,PRAD,GDSC1
SU11274,285,MET,RTK signaling,cnaPRAD7,3,3,.44042504053117054,3.4843611252125992,3.7453781351743385,,,.63820790994732524,-.26101700996173927,.20488941122020563,.81270141015307662,.84937827360972606,,.4007310042497505,0,PRAD,GDSC1
KIN001-042,289,GSK3B,WNT signaling,cnaPRAD7,3,3,.53224134351264107,4.3855394251888127,4.6848273924612736,,,.57883395772908597,-.29928796727246088,.78632960236397442,.11867995833465197,.68042595212016022,,.69881122418542041,0,PRAD,GDSC1
WYE-125132,317,mTOR,PI3K/MTOR signaling,cnaPRAD7,3,3,.41207261144104723,-.49789548057600141,-.95158725824939727,,,.65114639924735762,.45369177767339586,1.4209781442294447,.63656996726910442,.75580332518671445,,.74366291721795585,0,PRAD,GDSC1
Tenovin-6,342,SIRT,Chromatin histone acetylation,cnaPRAD7,3,3,.26734234988346867,2.358531232336126,2.2123085816011367,,,.76849026146011223,.1462226507349893,.26740083667693126,.72581221528020645,.96440587112200438,,.33593084525417571,96.440587112200433,PRAD,GDSC1
AT7867,356,AKT,PI3K/MTOR signaling,cnaPRAD7,3,3,.47604163284404138,2.9930556398776873,2.5095497428933675,,,.59121509524469062,.48350589698431978,1.0370246735690287,.99387673542316435,.63934328429008624,,.96357452357347695,0,PRAD,GDSC1
CI-1033,362,EGFR, ERBB2, ERBB4,RTK signaling,cnaPRAD7,3,3,1.030557354913336,2.4954693801565107,2.0470507864060896,,,.28519156511675242,.44841859375042104,.33880553998498775,.51368649878679229,.30034810148400493,,.019013694268799428,0,PRAD,GDSC1
PF-00299804,363,EGFR, ERBB2, ERBB4,RTK signaling,cnaPRAD7,3,3,.57839316762247972,2.2612068951471596,2.3719578356636255,,,.51791346451095233,-.11075094051646595,.18621316597925167,.19660652247802296,.40693062471593244,,.56944309424622319,0,PRAD,GDSC1
TWS119,366,GSK3,WNT signaling,cnaPRAD7,3,3,.34542337032689574,2.9185900636812447,3.1366532731946979,,,.69777216749226767,-.21806320951345315,.75476553749425934,.47685387516310224,.36369985333526073,,.23916688126272592,72.739970667052148,PRAD,GDSC1
Pilaralisib,372,PI3K,PI3K/MTOR signaling,cnaPRAD7,3,3,1.7591027495532507,3.6187588974690321,3.1608134697222874,,,.10775498371077341,.45794542774674474,.3066277724803369,.20376890517834498,.12180074368749365,,.99986982134035307,0,PRAD,GDSC1
GSK1059615,374,PI3K,PI3K/MTOR signaling,cnaPRAD7,3,3,.079863882984669496,.60220249564398209,.69537349155899753,,,.92784446278121202,-.093170995915015431,1.423852875111381,.83346187744974243,.99336120847825127,,.79577005309549209,99.336120847825129,PRAD,GDSC1
Voxtalisib,375,PI3K (class 1), DNAPK, MTOR,PI3K/MTOR signaling,cnaPRAD7,3,3,.049305471420368487,4.4404558599022774,4.396553915166681,,,.95488510374602109,.043901944735596388,.98601440011877961,.78321479858253484,.043713600763868515,,.0018358012857546319,0,PRAD,GDSC1
Brivanib, BMS-540215,376,VEGFR, PDGFR,RTK signaling,cnaPRAD7,3,3,.31285027316696529,3.9977072915233625,3.8554768931180186,,,.73753568822966065,.14223039840534391,.63815404584365398,.078307693991067462,.98070414909167425,,.28592664325927486,98.070414909167425,PRAD,GDSC1
BIBF-1120,380,VEGFR, PDGFR, FGFR,RTK signaling,cnaPRAD7,3,3,.34543008466854491,2.611465022081394,3.0097412561222252,,,.69554274233637314,-.39827623404083123,.98257280918638112,1.301271125800527,.60844291492868996,,.68509147343403032,0,PRAD,GDSC1
AST-1306,381,EGFR, ERBB4,RTK signaling,cnaPRAD7,3,3,.54876836712070276,2.0029929078366648,2.3384495316339353,,,.56880662607094246,-.33545662379727048,.11062479184368143,.85738738165216555,.34419844909248132,,.39751074190951519,0,PRAD,GDSC1
Apitolisib,382,mTOR, PI3K,PI3K/MTOR signaling,cnaPRAD7,3,3,.78375730164441881,.50344804004765797,-.22714797301424539,,,.43586939576544131,.73059601306190336,1.3085589361000285,.15987476164722175,.34039477359301434,,.68306772820848261,0,PRAD,GDSC1
LIMK1 inhibitor BMS4,406,LIMK1,Cytoskeleton,cnaPRAD7,3,3,1.0979186890294137,4.340698635674598,5.2031319092520967,,,.27547867510410856,-.86243327357749866,.47650546098456542,1.0035013544738005,.35137923735177135,,.72923543703417404,0,PRAD,GDSC1
kb NB 142-70,407,PKD,Other, kinases,cnaPRAD7,3,3,.77215119312712543,2.8083843179766057,2.4352042286907603,,,.40351357508986385,.37318008928584545,.39316564448366642,.55908594866021644,.28596725460095562,,.51606657378373233,0,PRAD,GDSC1
Sphingosine Kinase 1 Inhibitor II,408,Sphingosine Kinase,Other, kinases,cnaPRAD7,3,3,.39824628426454772,3.3749856365701647,3.5186596152101082,,,.65140128807582154,-.14367397863994347,.37460115730202392,.34638003308246057,.46503285313377979,,.45144741319613335,0,PRAD,GDSC1
eEF2K Inhibitor, A-484954,409,eEF2K,Other, kinases,cnaPRAD7,3,3,.84584626615198366,5.0377944115869377,5.6146924224457457,,,.3939172787126804,-.57689801085880799,.92159886994020568,.2846103403549709,.28604000363253657,,.60572216523461919,0,PRAD,GDSC1
MetAP2 Inhibitor, A832234,410,MetAP2,Other,cnaPRAD7,3,3,.16940789817124169,2.4552171473868847,2.3550964559221286,,,.84918285195599019,.10012069146475611,.3730915809405323,.74791267866710154,.90361035146642954,,.87732195579180894,90.361035146642948,PRAD,GDSC1
Venotoclax,412,BCL-2 selective,Apoptosis regulation,cnaPRAD7,3,3,.11510059779218655,1.1696384543359664,1.150557180956473,,,.89495292425328676,.019081273379493391,.18116844104891602,.14880663695310933,.97693796945418077,,.67219008494429233,97.693796945418072,PRAD,GDSC1
CPI-613,415,Metabo, Mitochondria,Other,cnaPRAD7,3,3,.002472020094044259,5.3623844983224318,5.3619397954405068,,,.99775807693638918,.00044470288192499652,.13225928821501085,.21732823404706061,.80942768338341775,,.50607742404042722,96.454471430313603,PRAD,GDSC1
CAY10566,416,Stearoyl-CoA desaturase,Other,cnaPRAD7,3,3,1.0746732443384812,3.3606018492408842,3.6938414521043867,,,.278326903915118,-.33323960286350252,.20598635837069193,.38713630044449648,.09647356305575662,,.25962337667033808,0,PRAD,GDSC1
Ara-G,427,Anti-metabolite,Other,cnaPRAD7,3,3,.73109953676276451,5.6407575076775158,5.3958633095952679,,,.43445913600783398,.24489419808224788,.22822635577762504,.41511260548300405,.66966022257805013,,.036388472692530996,96.546823347693234,PRAD,GDSC1
Pemetrexed,428,TYMS,DNA replication,cnaPRAD7,3,3,1.070688728354948,2.3445204755422786,3.5372413710492494,,,.29859540971767035,-1.1927208955069708,1.4903305042247481,.51068320374892584,.24806116061915764,,.77400403490875946,0,PRAD,GDSC1
Alisertib,431,AURKA,Mitosis,cnaPRAD7,3,3,.42395663584130572,1.1770853969855095,1.5456477237813402,,,.65189133022224677,-.36856232679583067,.24288485529257606,1.2052011910570177,.33062634015265596,,.25917928939573337,0,PRAD,GDSC1
Flavopiridol,432,CDK,Cell cycle,cnaPRAD7,3,3,1.4048473601728435,-1.0160580401018147,-1.5789454293416394,,,.21932461658423733,.56288738923982473,.55708309459477623,.10363172565585926,.077957409852019169,,.39589432921694495,0,PRAD,GDSC1
C-75,435,FAS,Apoptosis regulation,cnaPRAD7,3,3,.1732402256420118,4.9980934490950384,4.8033720732755576,,,.84475690792004332,.19472137581948079,.7962332231265935,1.3757718204407732,.80609635195766849,,.23423431096422731,0,PRAD,GDSC1
CAP-232, TT-232, TLN-232,436,Glycolysis,Metabolism,cnaPRAD7,3,3,.49352880326733911,4.0733578827490051,4.8688619398204169,,,.58115187772564258,-.79550405707141181,1.3360749710270661,1.8469300626063399,.39959184635306372,,.44297393653680545,0,PRAD,GDSC1
Trichostatin A,437,HDAC,Chromatin histone acetylation,cnaPRAD7,3,3,.72807516804833061,-1.9522094149401605,-2.7904359938005796,,,.43427564607175806,.83822657886041907,.817954632021341,1.4077973428908079,.56575049015061751,,.63434949893251946,0,PRAD,GDSC1
Panobinostat,438,HDAC,Chromatin histone acetylation,cnaPRAD7,3,3,.2027996730547347,-3.7772442419601258,-3.6088118773688471,,,.81694959815243473,-.16843236459127864,.70706815800474443,.93788786918280675,.74841957032135831,,.76336259771512727,0,PRAD,GDSC1
LCL161,439,XIAP, cIAP1, cIAP2,Apoptosis regulation,cnaPRAD7,3,3,.22269100835790351,3.5441811159704693,3.3482417912209019,,,.80021121176241572,.19593932474956732,.70354487920064579,1.0263381488217487,.96567508241149103,,.42137349221844228,96.567508241149099,PRAD,GDSC1
IMD-0354,442,IKKb,Other, kinases,cnaPRAD7,3,3,.29143860838956576,.17692997767417271,.2970831413646054,,,.74496289262201099,-.12015316369043269,.51944840435444561,.26479514461398285,.77819831108277548,,.95853269804303531,0,PRAD,GDSC1
MIM1,446,MCL-1,Apoptosis regulation,cnaPRAD7,3,3,.049179874188750528,3.1615309901130253,3.1333469011649364,,,.95511012399210182,.028184088948088881,.65410024751317686,.47853764507490404,.8783253460759608,,.77587893851671386,0,PRAD,GDSC1
ETP-45835,447,MNK1, MNK2,Other, kinases,cnaPRAD7,3,3,.052068688826572312,5.0087401967180512,5.0422068598264493,,,.95222970932047213,-.033466663108398187,.61740815940779137,.66711188061687221,.92389332062146423,,.9068345740442153,92.389332062146423,PRAD,GDSC1
CD532,449,AURKA,Mitosis,cnaPRAD7,3,3,.2836109044968807,.41895953149016146,.31614280736930506,,,.75850538175966387,.10281672412085641,.11779323731006992,.49897593758560288,.48862275134621569,,.35215615155054458,0,PRAD,GDSC1
NSC319726,461,P53 Mut specific,p53 pathway,cnaPRAD7,3,3,1.0799153134491339,-3.7959935496587369,-5.3929952696983685,,,.28188719603616147,1.5970017200396316,1.8896465001654965,.89613655091299527,.40961421816999594,,.44480718110137346,0,PRAD,GDSC1
ARRY-520,474,KIF11,Mitosis,cnaPRAD7,3,3,.59860674629885369,-4.0462872814434929,-3.415023798530747,,,.50464587071597922,-.63126348291274592,1.1146017169010949,.99087522717490328,.030561366478472195,,.020087188486693372,0,PRAD,GDSC1
SB505124,476,TGFBR1, ACVR1B, ACVR1C,RTK signaling,cnaPRAD7,3,3,1.6423820444428052,2.9570389671885824,1.6057417542795698,,,.12652338474519756,1.3512972129090126,.97792286420516827,.63052111216731921,.20163978758651538,,.58052509068865565,0,PRAD,GDSC1
A-83-01,477,TGFB,Other,cnaPRAD7,3,3,.614690544185859,4.1827321796897161,4.89145300972074,,,.49551610953656494,-.70872083003102393,1.0111716753051312,1.2791479732988531,.7186103611918464,,.36134179803898986,0,PRAD,GDSC1
LDN-193189,478,BMP,Other,cnaPRAD7,3,3,1.3946943617187362,.30023794230805928,1.0212731695506343,,,.16522979434193458,-.72103522724257507,.46680753231929101,.56270459982567167,.16160548376274411,,.80730943768443375,0,PRAD,GDSC1
FTY-720,546,S1P,Other,cnaPRAD7,3,3,2.1245160217370209,2.1637445539212261,2.782279775035938,,,.063091484465877368,-.61853522111471193,.3228354937227208,.25554692543855873,.044527570659481278,,.69285163003440153,0,PRAD,GDSC1
BAM7,552,Bax activator,Other,cnaPRAD7,3,3,.28332512154805262,4.6049934719829624,4.3185327183878695,,,.74641719357731207,.28646075359509293,1.080958154650999,.93597193646587884,.74310305262619147,,.92104908230516758,95.705909134238851,PRAD,GDSC1
AGI-6780,562,IDH2(R140Q),Metabolism,cnaPRAD7,3,3,.57851742956688479,1.4946185460676651,1.7745876552039406,,,.51793955218082588,-.27996910913627548,.50228232554062502,.464879494634174,.63196037931712856,,.75326008666497613,0,PRAD,GDSC1
Kobe2602,563,RAS effector,RTK signaling,cnaPRAD7,3,3,.27459447126864006,4.6948994977357152,4.4782308581684207,,,.7535642933068154,.21666863956729454,.80394719934279335,.77386512686574993,.73013989915155619,,.86553917443174044,0,PRAD,GDSC1
LGK974,573,PORCN,WNT signaling,cnaPRAD7,3,3,.88203770324173847,2.7858009725297479,3.2546676061666555,,,.35152226914442242,-.46886663363690761,.39808053692500972,.63770657812324294,.47586224040815306,,.63116911385078356,0,PRAD,GDSC1
Wnt-C59,574,PORCN,WNT signaling,cnaPRAD7,3,3,2.0238859026205516,2.3728341809609574,3.2039064718813086,,,.12230798341077111,-.83107229092035118,.11317521958555719,.56958636587820022,.14772805936434516,,.31180575171935659,0,PRAD,GDSC1
RU-SKI 43,576,Shh,Other,cnaPRAD7,3,3,.73184581174705143,5.164958601342537,4.7121149942050886,,,.42239042690936318,.45284360713744842,.55803796859438237,.67405054334330494,.51123847915810816,,.83507784775745308,0,PRAD,GDSC1
Vinblastine,1004,Microtubule destabiliser,Mitosis,cnaPRAD7,3,3,.42344982217288707,-4.0478669611007589,-4.5435547408279229,,,.65338511187675119,.49568777972716394,1.6338054321424844,.2669456455546127,.85430519429151874,,.42614424554682562,0,PRAD,GDSC1
Cisplatin,1005,DNA crosslinker,DNA replication,cnaPRAD7,3,3,1.5519065386383837,2.4853815074572254,4.14698003237433,,,.15872113935398932,-1.6615985249171046,.64285925030303293,1.3709311538703193,.099626739643606618,,.63558814259286356,0,PRAD,GDSC1
Cytarabine,1006,Antimetabolite,Other,cnaPRAD7,3,3,.52822241343199516,.80129406968764849,.16200893818266193,,,.56201524029126493,.63928513150498656,1.4959695195906295,.83157776179014187,.76800408400583464,,.4238387673330829,0,PRAD,GDSC1
Docetaxel,1007,Microtubule stabiliser,Mitosis,cnaPRAD7,3,3,.096346450335458439,-5.7246059958628583,-5.8265411639972422,,,.91220256365471575,.10193516813438386,.89275884080109746,1.2007235515556989,.96556744602699207,,.87210617242244015,96.556744602699212,PRAD,GDSC1
Methotrexate,1008,Antimetabolite,DNA replication,cnaPRAD7,3,3,2.0614700314856313,-.36617731253091684,.79278158950702615,,,.09876091052394563,-1.1589589020379429,.74035721927894327,.28984368049239856,.13760183042035187,,.20525029790578891,0,PRAD,GDSC1
Tretinoin,1009,Retinoic acid,Other,cnaPRAD7,3,3,.61651648931697345,3.8489029397390624,4.4117483648556748,,,.49738076628648348,-.5628454251166124,1.0659081333283082,.72854353816152095,.3118057054611455,,.40459292219344795,0,PRAD,GDSC1
Gefitinib,1010,EGFR,EGFR signaling,cnaPRAD7,3,3,.47580568069974727,.8105199927089185,1.4642779399427377,,,.59838969531742037,-.65375794723381919,1.6785101600699956,.97896196196748242,.6575870800681467,,.90632530543585454,0,PRAD,GDSC1
Navitoclax,1011,BCL2, BCL-XL, BCL-W,Apoptosis regulation,cnaPRAD7,3,3,1.2108769637926764,1.7209476678544993,3.2755565968507891,,,.27454344620932392,-1.5546089289962899,1.8088595537398973,.15707588016861046,.34648178236989824,,.48670217447803449,0,PRAD,GDSC1
Vorinostat,1012,HDAC inhibitor Class I, IIa, IIb, IV,Chromatin histone acetylation,cnaPRAD7,3,3,.39547424598692515,2.1188339886628724,1.4190755274290556,,,.67597496194430351,.6997584612338168,2.5021702179036978,.028464237172467158,.8945971981781986,,.38561123395265151,0,PRAD,GDSC1
Nilotinib,1013,ABL,ABL signaling,cnaPRAD7,3,3,.45088906556476005,2.9569264920196603,2.7234534189772823,,,.61416953934874541,.23347307304237797,.40781728558982661,.60821970763428412,.73298460169635837,,.72279365051873401,0,PRAD,GDSC1
Refametinib,1014,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,2.5787505895044718,1.3190370568745735,3.8404998827114656,,,.047789706879965248,-2.5214628258368919,1.206368878409515,.67586973523460858,.081337711344982216,,.43849483557132868,0,PRAD,GDSC1
CI-1040,1015,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,1.6049083329559641,2.8834515147371724,4.1161246297135783,,,.12309079897955161,-1.2326731149764059,.8346444819766673,.69513648911357429,.1778767264585622,,.81834853780657024,0,PRAD,GDSC1
Temsirolimus,1016,MTOR,PI3K/MTOR signaling,cnaPRAD7,3,3,.17048988979789328,-1.6487448399164577,-2.0067250625286355,,,.85159885328940033,.35798022261217777,.79813886320675564,2.8601717899593431,.82926301458951301,,.91265425125756972,96.290713045225957,PRAD,GDSC1
Olaparib,1017,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,.28513999556865116,3.5359254797341024,3.7880918454981809,,,.75274480926814191,-.25216636576407847,1.156967919924792,.47498415376792896,.40413592585701069,,.2387564290275081,0,PRAD,GDSC1
Bosutinib,1019,SRC, ABL, TEC,Other, kinases,cnaPRAD7,3,3,1.4178594555834163,2.2790101152235782,3.2593276370628192,,,.22368938067647176,-.98031752183924104,.97599735533818199,.059292507377428479,.074454086648370749,,.38718458278425999,0,PRAD,GDSC1
Lenalidomide,1020,CRBN,Protein stability and degradation,cnaPRAD7,3,3,1.2735545375724497,4.0326149543662293,4.3113179835509419,,,.19405115918564039,-.27870302918471257,.22495856577864665,.21254271019323726,.23810563946480362,,.97409156674842212,47.621127892960722,PRAD,GDSC1
Axitinib,1021,PDGFR, KIT, VEGFR,RTK signaling,cnaPRAD7,3,3,2.4563825803002004,.90519752382639718,2.4596088187421494,,,.040311492496642155,-1.5544112949157523,.66888891561385222,.5945351750297736,.081610822734197189,,.58231850162701415,0,PRAD,GDSC1
AZD7762,1022,CHEK1, CHEK2,Cell cycle,cnaPRAD7,3,3,.48222662491613033,.031493293712357762,.68146007111334195,,,.61078203664572761,-.64996677740098419,1.8697762122878654,.3705530506600862,.39040386713814901,,.41196290220636961,0,PRAD,GDSC1
Lestaurtinib,1024,FLT3, JAK2, NTRK1, NTRK2, NTRK3,Other, kinases,cnaPRAD7,3,3,.30647138731065476,-.02033057345341514,-.2713104966950099,,,.73306780621159873,.25097992324159474,.51055677100190699,1.03953762591474,.72641434953459127,,.92417684989191096,0,PRAD,GDSC1
Tanespimycin,1026,HSP90,Protein stability and degradation,cnaPRAD7,3,3,.17739421340082304,-.12902329164421897,-.40998996195191806,,,.83908975258913387,.28096667030769906,1.4058312676010847,1.7437976616804312,.8606643782263681,,.30575837204836154,0,PRAD,GDSC1
VX-702,1028,p38,JNK and p38 signaling,cnaPRAD7,3,3,1.1962158643944161,.98706074006895228,3.1313921105722797,,,.2796698789036387,-2.1443313705033273,2.5305259369758009,.15243655786686153,.36807301667599879,,.34664576362139388,0,PRAD,GDSC1
Motesanib,1029,VEGFR, RET, KIT, PDGFR,RTK signaling,cnaPRAD7,3,3,.75114869236292414,1.6034054909831148,2.7463984758430242,,,.43047647487929119,-1.1429929848599094,1.9639726418726424,.87960804058133579,.5093565236933757,,.79922197052168131,0,PRAD,GDSC1
KU-55933,1030,ATM,Genome integrity,cnaPRAD7,3,3,.5878057621958831,3.1624044692174498,4.0201896516401519,,,.52161122345668753,-.85778518242270207,1.8034337132860905,1.0033654080369871,.47259705878245972,,.75607102138425941,0,PRAD,GDSC1
Elesclomol,1031,HSP90,Protein stability and degradation,cnaPRAD7,3,3,.60096022701513063,-3.5334354937328598,-4.4150993146685069,,,.52325127232572977,.8816638209356471,1.9402370164411178,.73498096363082066,.68924760371715277,,.49755603063070464,0,PRAD,GDSC1
Afatinib,1032,ERBB2, EGFR,EGFR signaling,cnaPRAD7,3,3,.39602730757501697,.91245934536434492,1.4027127276087692,,,.67541988963029365,-.49025338224442427,1.7490270836489135,.07639924900769722,.82851345835478618,,.5615030107998652,0,PRAD,GDSC1
Vismodegib,1033,SMO,Other,cnaPRAD7,3,3,1.4179977552510654,3.6012734559590229,5.046294068285019,,,.20324661993061802,-1.4450206123259961,1.3735371820922944,.4362913707705075,.28145550283385473,,.20835924506777909,0,PRAD,GDSC1
PLX-4720,1036,BRAF,ERK MAPK signaling,cnaPRAD7,3,3,.24165301693788555,4.108468710921044,4.358106778864145,,,.78301093747055717,-.24963806794310095,.88202355199990767,1.164642443259073,.59755521013936752,,.48742215158643759,0,PRAD,GDSC1
BX795,1037,TBK1, PDK1 (PDPK1), IKK, AURKB, AURKC,Other, kinases,cnaPRAD7,3,3,.33265889040045749,2.6178841772686288,2.1831107752048138,,,.71353347796608113,.43477340206381498,1.6954713616376393,.73599587344920248,.84751296168101076,,.10116808919077359,0,PRAD,GDSC1
NU7441,1038,DNAPK,Genome integrity,cnaPRAD7,3,3,1.081515513518289,2.9170125610688462,2.1022239033793464,,,.25614353942342788,.81478865768949982,.7751100007952878,.73099766309937342,.42767321505411604,,.21829551838711045,0,PRAD,GDSC1
SL0101,1039,RSK, AURKB, PIM1, PIM3,Other, kinases,cnaPRAD7,3,3,.066919492090705635,4.4555590510286054,4.5072260484535276,,,.9386283181108982,-.051666997424922201,.79356140606390979,.74997728749274228,.83670315499577252,,.70615420163746223,0,PRAD,GDSC1
Doramapimod,1042,p38, JNK2,JNK and p38 signaling,cnaPRAD7,3,3,.78542841841459343,3.2349298396289492,4.0966807267952445,,,.41840725229420522,-.86175088716629533,1.4544545940759954,.54049903080000372,.54070781208403185,,.59155289781869547,0,PRAD,GDSC1
JNK Inhibitor VIII,1043,JNK,JNK and p38 signaling,cnaPRAD7,3,3,.28162122268393186,4.0603872678869646,4.3522265102320752,,,.7481318399254373,-.29183924234511061,1.1308827289944325,.9321311764737672,.77784845223714727,,.98210023304601668,0,PRAD,GDSC1
Nutlin-3a (-),1047,MDM2,p53 pathway,cnaPRAD7,3,3,.33271042615316576,3.6339478664184739,3.1228270533983107,,,.70859420507848547,.51112081302016321,1.132383990881594,1.8541120727791092,.30870599114049091,,.17055924219806493,0,PRAD,GDSC1
Mirin,1048,MRE11,Genome integrity,cnaPRAD7,3,3,1.8557383229338233,4.1806185139769187,6.0650185392495635,,,.12909106987809091,-1.8844000252726447,.44017280028320033,1.3669325574397801,.04501562359785783,,.49340399577754085,0,PRAD,GDSC1
PD173074,1049,FGFR1, FGFR2, FGFR3,RTK signaling,cnaPRAD7,3,3,1.1768996122697462,1.4340841397740147,3.0240225987081697,,,.27169235693844551,-1.589938458934155,1.8472485602846778,.48767999663413814,.29214651279822079,,.8688643053434949,0,PRAD,GDSC1
ZM447439,1050,AURKA, AURKB,Mitosis,cnaPRAD7,3,3,.55738201308154722,3.0727852522344841,2.6404895958969585,,,.53268876277411736,.43229565633752554,.73446007246582035,.81463144540573218,.85871700924055694,,.12822519744618199,0,PRAD,GDSC1
RO-3306,1052,CDK1,Cell cycle,cnaPRAD7,3,3,.11223345791700513,3.2431951526503191,3.1235181960324585,,,.89786708775543966,.1196769566178606,1.2146181903985867,.89374829584513027,.58226238170809219,,.10007125952490376,0,PRAD,GDSC1
MK-2206,1053,AKT1, AKT2,PI3K/MTOR signaling,cnaPRAD7,3,3,.37993130967531491,1.2678318659907075,.81168405012139067,,,.66621265492514326,.45614781586931685,1.2679784647106165,1.1292210686545936,.27776207945211889,,.16741320540941207,0,PRAD,GDSC1
Palbociclib,1054,CDK4, CDK6,Cell cycle,cnaPRAD7,3,3,.23749024393558554,1.5180413344376937,1.1305331715288309,,,.78748858711791037,.38750816290886281,1.910501354718297,1.2941198025164706,.65195069867911326,,.59509560021513519,0,PRAD,GDSC1
Dactolisib,1057,PI3K (class 1), MTORC1, MTORC2,PI3K/MTOR signaling,cnaPRAD7,3,3,.87885005423091667,-1.0821802394981705,-3.0046394205336888,,,.34263928147926725,1.9224591810355183,2.2642100096881301,2.1079405865990926,.4659855988295199,,.68282759576609986,0,PRAD,GDSC1
Pictilisib,1058,PI3K (class 1),PI3K/MTOR signaling,cnaPRAD7,3,3,.32030007644542624,1.6095170830521,1.1289402622538534,,,.71579136335944105,.4805768207982466,1.6590998908516705,1.3227854623312882,.69760040487643793,,.87217847850827068,0,PRAD,GDSC1
AZD8055,1059,MTORC1, MTORC2,PI3K/MTOR signaling,cnaPRAD7,3,3,.43265148313490281,.3977251861783706,-.011127497162269387,,,.62917374645549917,.40885268334064001,.71106900663733918,1.1315497934519432,.51734825020996489,,.61353593451062571,0,PRAD,GDSC1
PD0325901,1060,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,.36989606543548675,.4592039395531235,.90350544898188179,,,.6795443709894029,-.44430150942875829,1.4721812849347586,.84747622715429272,.18608962803802301,,.086652941967600636,0,PRAD,GDSC1
SB590885,1061,BRAF,ERK MAPK signaling,cnaPRAD7,3,3,.72339668840598315,3.3017379030990153,3.724768438239499,,,.43401940820336515,-.42303053514048372,.44336660464588323,.69811877324265315,.4227730664727285,,.84150307457901963,0,PRAD,GDSC1
Selumetinib,1062,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,.30073716096864256,3.0094524153156974,3.3218997713909317,,,.74073506448184268,-.31244735607523433,.52763899061675612,1.371270467894562,.58364767618199664,,.55117435303716156,0,PRAD,GDSC1
CCT007093,1067,PPM1D,Cell cycle,cnaPRAD7,3,3,1.6337168622431772,3.9934039833347321,4.5950772722446089,,,.17290348822779056,-.60167328890987681,.509642319813287,.10738843028505153,.22259250989530241,,.3630688494754491,0,PRAD,GDSC1
EHT-1864,1069,RAC1, RAC2, RAC3,Cytoskeleton,cnaPRAD7,3,3,.21159975222592819,4.2268224322860677,4.0654630489879482,,,.80962772068058697,.1613593832981195,.62382761520546293,.87969407190024662,.33113574683393954,,.12363458177313084,0,PRAD,GDSC1
Avagacestat,1072,Amyloid beta20, Amyloid beta40,Other,cnaPRAD7,3,3,.73344718171821988,3.1810390399617199,3.8481184969498159,,,.42228173464451407,-.66707945698809601,1.0080780073043436,.79887739300896521,.52036965370499877,,.79720668453761245,0,PRAD,GDSC1
BMS-536924,1091,IGF1R, IR,IGF1R signaling,cnaPRAD7,3,3,.69201323199696685,1.763933957068258,2.5188062120249346,,,.46083858876950207,-.75487225495667665,.67719344164476325,1.3860920039974767,.42562169605911054,,.79638416189129213,85.124339211822104,PRAD,GDSC1
Cetuximab,1114,EGFR,EGFR signaling,cnaPRAD7,3,3,.1375701551315042,5.861010050135655,5.9947349890761581,,,.87445236419061301,-.13372493894050308,.9224768272191527,1.0192130415021896,.9360917279972818,,.85918512809403325,93.609172799728185,PRAD,GDSC1
PF-4708671,1129,S6K1,PI3K/MTOR signaling,cnaPRAD7,3,3,.92728092196029566,3.6698774269144376,4.1816274344901521,,,.35904434542666741,-.51175000757571443,.21851828170162779,.74926503736095895,.50962349407115415,,.10191205315836256,0,PRAD,GDSC1
Serdemetan,1133,MDM2,p53 pathway,cnaPRAD7,3,3,.92653065213997288,2.7205645747504108,1.7726607970404291,,,.37382454789812641,.94790377770998169,.059678298790335101,1.4456052009595874,.28792008699377331,,.71892693071109703,0,PRAD,GDSC1
AZD4547,1135,FGRF1, FGFR2, FGFR3,RTK signaling,cnaPRAD7,3,3,1.2766898380666878,2.9499731430308991,4.1328894068011008,,,.24951361148243453,-1.1829162637702018,1.2855301478318779,.25377154177210043,.065454185266027115,,.26094083701066256,0,PRAD,GDSC1
Capivasertib,1136,AKT,PI3K/MTOR signaling,cnaPRAD7,3,3,.51785215423816366,2.9063123017997654,1.7379660069290772,,,.5873521946057737,1.1683462948706882,.56231849639651055,3.1407199380897119,.33318258625441893,,.3460189107887956,0,PRAD,GDSC1
TW 37,1149,BCL2, BCL-XL, MCL1,Apoptosis regulation,cnaPRAD7,3,3,1.1870059110244726,-1.1264254890659131,-.14037080476142486,,,.26685328134927472,-.98605468430448828,1.1306949425437571,.31887108391845104,.24574042835328788,,.93057224285045803,0,PRAD,GDSC1
Rucaparib,1175,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,.9444303608294925,2.9299618795340177,3.50480773963598,,,.32845928313406592,-.57484586010196237,.41511753179983263,.75407845035850785,.35704621357896638,,.01634521878058922,71.409242715793269,PRAD,GDSC1
AZ20,1184,ATR,Genome integrity,cnaPRAD7,3,3,.6498659771403873,.57847792565975287,1.0986414843302188,,,.47744742547809788,-.52016355867046593,.94910224045886071,.61687812012501542,.56307448095535917,,.82959913089543913,0,PRAD,GDSC1
KU-60019,1185,ATM,Genome integrity,cnaPRAD7,3,3,.68756597729382307,3.0371675906152849,3.7459661825707524,,,.4574309508427496,-.70879859195546757,1.2566131092110613,.73915769946757992,.55393398608346656,,.77654729352644369,97.239563541110144,PRAD,GDSC1
GSK269962A,1192,ROCK1, ROCK2,Cytoskeleton,cnaPRAD7,3,3,1.444465708485513,1.5148443778950915,2.8292207760472592,,,.15731803930441307,-1.3143763981521677,.77042856448561714,1.0307374050808671,.2086534790118752,,.86852086915724969,0,PRAD,GDSC1
SB505124,1194,TGFBR1, ACVR1B, ACVR1C,RTK signaling,cnaPRAD7,3,3,.18773026744704355,4.1605046575092333,3.989222898362943,,,.83624311122860029,.17128175914629029,.39481407921717482,1.2284154396976192,.22579836062171135,,.057541265843300833,0,PRAD,GDSC1
Tamoxifen,1199,ESR1,Hormone-related,cnaPRAD7,3,3,1.233843448006019,3.3812358467894676,3.9157075562869976,,,.24681420351285943,-.53447170949752998,.57964005531942409,.1982442376925255,.31074081615244947,,.084392084879416129,0,PRAD,GDSC1
JQ1,1218,BRD2, BRD3, BRD4, BRDT,Chromatin other,cnaPRAD7,3,3,1.557046974485111,1.7350803775959882,2.3430458231787497,,,.14812108663182608,-.60796544558276144,.48116804907753535,.2709173645114632,.2372116884528897,,.19748114028482805,0,PRAD,GDSC1
PFI-1,1219,BRD4,Chromatin other,cnaPRAD7,3,3,1.3499279118076108,2.8322112177748413,1.9164462092221111,,,.23270323714004149,.91576500855273024,.94459587995958549,.16774774238252396,.079311489723789833,,.36489753169843653,0,PRAD,GDSC1
IOX2,1230,EGLN1,Other,cnaPRAD7,3,3,.054892353199400522,-.41844800487609396,-.47547344600587599,,,.952044672904651,.057025441129782029,.3116057918139547,1.4357436542782425,.68929393275598549,,.37558315495627909,0,PRAD,GDSC1
UNC0638,1236,G9a and GLP methyltransferases,Chromatin histone methylation,cnaPRAD7,3,3,.51291685095340589,4.2744644619043894,3.3010933977451029,,,.56487249671011619,.97337106415928654,2.0513868617097035,1.7304543068904727,.39246703295019375,,.45207404282676655,0,PRAD,GDSC1
CHIR-99021,1241,GSK3A, GSK3B,WNT signaling,cnaPRAD7,3,3,.30944676820878825,3.3453447964827974,3.6317075250783808,,,.73208003728125937,-.28636272859558343,1.1980214008190662,.52676682558157195,.37506469667489778,,.22450341100344609,0,PRAD,GDSC1
(5Z)-7-Oxozeaenol,1242,TAK1,Other, kinases,cnaPRAD7,3,3,1.228772942040167,1.3514776171925691,2.2976292461455778,,,.23916920297678748,-.94615162895300875,1.0024112649752912,.42539721626223548,.20418271736320026,,.80309964784271148,0,PRAD,GDSC1
Piperlongumine,1243,Induces reactive oxygen species,Other,cnaPRAD7,3,3,.46770810516555239,1.3442988861214875,1.4842427781853118,,,.5988639938198238,-.13994389206382429,.2637235017648516,.33091629396645178,.36390807379957912,,.34913399786613325,0,PRAD,GDSC1
Daporinad,1248,NAMPT,Metabolism,cnaPRAD7,3,3,.63207460937735505,-1.7399296866943281,-.15375942679435259,,,.4932200975828302,-1.5861702598999756,1.7207586746701153,3.1038423000161597,.5565540230760414,,.89212970764856547,0,PRAD,GDSC1
Talazoparib,1259,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,.62895462237746946,1.3083163616295812,1.7802056912946085,,,.50495828370408746,-.47188932966502728,.38758489856591116,.98772719310711865,.66604310305243164,,.50741607088417429,0,PRAD,GDSC1
rTRAIL,1261,TRAIL receptor agonist,Apoptosis regulation,cnaPRAD7,3,3,.16545012032597789,-.43146094996688517,-.35226858022630131,,,.85574499616191468,-.079192369740583857,.18849062537138114,.65013775946535379,.6438271553309679,,.45985903818619134,0,PRAD,GDSC1
UNC1215,1262,L3MBTL3,Chromatin other,cnaPRAD7,3,3,1.3548830588097138,2.4117339237037747,2.6136249200223998,,,.17293086419452458,-.20189099631862506,.1554432228177422,.14228600862171858,.083316222114358102,,.38690016438617431,0,PRAD,GDSC1
SGC0946,1264,DOT1L,Chromatin histone methylation,cnaPRAD7,3,3,.98967385864035107,1.8687968905180181,.87166062407758782,,,.34423544465702388,.9971362664404303,.22160842305481498,1.4075384530904875,.21930421842377812,,.57076905121965149,0,PRAD,GDSC1
ICL1100013,1266,N-myristoyltransferase 1/2,Other,cnaPRAD7,3,3,.16939126018086645,1.7932924056211832,1.6026561177343766,,,.85475200655805172,.19063628788680664,.08823256556619534,1.5891364716347978,.61734936924679062,,.41765497207694741,0,PRAD,GDSC1
XAV939,1268,TNKS1, TNKS2,WNT signaling,cnaPRAD7,3,3,1.0675114327092254,2.6767228837118693,3.7606699841425559,,,.30837976560535679,-1.0839471004306866,1.3919447231264654,.35291494315401239,.39657366502024272,,.56075855745645575,0,PRAD,GDSC1
PLX-4720,1371,BRAF,ERK MAPK signaling,cnaPRAD7,3,3,.39679460370561132,3.9901557237290555,4.2646200293886816,,,.65480323673529595,-.2744643056596261,.79360274313350521,.57192899380845619,.94326092117839955,,.11451181085231313,94.326092117839949,PRAD,GDSC1
Trametinib,1372,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,2.1676486993234039,-.52441901925303513,2.6311596298533035,,,.11631522921422519,-3.1555786491063387,2.0540756549624239,.13875859816339225,.12703005847590959,,.35300686277347421,0,PRAD,GDSC1
Dabrafenib,1373,BRAF,ERK MAPK signaling,cnaPRAD7,3,3,.088774849157207819,3.6684398794091311,3.5709829748572091,,,.91991855373059528,.097456904551922019,.77052503947296846,1.3478184847262507,.55552793578114401,,.23436439941864989,0,PRAD,GDSC1
Temozolomide,1375,DNA alkylating agent,DNA replication,cnaPRAD7,3,3,.41590453374289466,5.8298297274908579,5.9456829505975568,,,.63758227667796086,-.11585322310669888,.29280641609224189,.26353877427948341,.6459504624967477,,.92636572025237984,0,PRAD,GDSC1
Afatinib,1377,ERBB2, EGFR,EGFR signaling,cnaPRAD7,3,3,1.254317531320178,2.9708826383878457,4.766863957584051,,,.26198467611517035,-1.7959813191962053,2.0151584765487112,.19865727480191392,.3463502050136324,,.29479701801070357,0,PRAD,GDSC1
Bleomycin (50 uM),1378,dsDNA break induction,DNA replication,cnaPRAD7,3,3,.58792770596404076,2.0538712819394807,3.2571812879224091,,,.51352344683907913,-1.2033100059829285,2.2820701202520004,1.7804760743609112,.43995637801913257,,.66694458422894232,87.991275603826509,PRAD,GDSC1
AZD3514,1382,AR,Hormone-related,cnaPRAD7,3,3,.71425517711820141,3.2823681495592041,2.6795091448342432,,,.43607215851838438,.6028590047249609,.97355829427202978,.69064236144152158,.034997041964850067,,.033269719868706089,0,PRAD,GDSC1
Doxorubicin,1386,Anthracycline,DNA replication,cnaPRAD7,3,3,.042467333610977924,-1.6087460864322634,-1.6503166512793852,,,.96265901819444388,.041570564847121849,.37784853661076773,1.3317866278793786,.47667393983391776,,.1297258797993793,0,PRAD,GDSC1
Bleomycin (10 uM),1392,dsDNA break induction,DNA replication,cnaPRAD7,3,3,.71401986834252784,1.7504213577059267,2.5703885413289895,,,.4312147303629793,-.81996718362306287,1.1472621581354665,1.1494996852509154,.47704587277610083,,.99542531121815159,0,PRAD,GDSC1
Gemcitabine,1393,Pyrimidine antimetabolite,DNA replication,cnaPRAD7,3,3,.52629891972258391,-4.0119469625220434,-3.6748708386310085,,,.58195401576158368,-.33707612389103492,.89240010510370504,.15496226895924931,.64726439440966921,,.824008416712398,0,PRAD,GDSC1
AZD6738,1394,ATR,Genome integrity,cnaPRAD7,3,3,.41850928829042106,1.5238587161024189,1.8845126917915571,,,.63579410749220089,-.36065397568913826,.92196485056917066,.79701729067208238,.68959496710471158,,.93571305127181914,0,PRAD,GDSC1
AZD5438,1401,CDK2,Cell cycle,cnaPRAD7,3,3,.015721336965653414,.91259495012469216,.90411001576118366,,,.98556109714432882,.0084849343635085006,.53074448585312706,.54852543940670151,.75829473388716173,,.43622613451174747,91.222320800066697,PRAD,GDSC1
AZD7762,1402,CHEK1, CHEK2,Cell cycle,cnaPRAD7,3,3,.19965621971731146,-.021498989644188171,.2009481240139841,,,.82350131051864961,-.22244711365817227,1.4291088283984639,.66355967898246226,.70818872612729655,,.65643372660850741,0,PRAD,GDSC1
AZD6094,1403,MET,RTK signaling,cnaPRAD7,3,3,.037171538426797601,3.1464498700933277,3.1584757707343036,,,.96636829815718994,-.012025900640975973,.23033560343119416,.39532470009424386,.49131668819934315,,.13638484344263249,0,PRAD,GDSC1
Dyrk1b_0191,1407,DYRK1B,Other, kinases,cnaPRAD7,3,3,.24466095691920736,1.4477723064311248,1.5653461037933465,,,.78689723958636315,-.11757379736222173,.63397223355801646,.24484959700490608,.53244389873805642,,.37518536059685964,0,PRAD,GDSC1
AZD4877,1409,EG5,Mitosis,cnaPRAD7,3,3,.43804707199501064,-4.2903220600407224,-3.9934793363019447,,,.62451150741455064,-.29684272373877763,.80428944780431888,.52109337466935346,.59691448007985082,,.83007694417354927,0,PRAD,GDSC1
EphB4_9721,1413,EPHB4,RTK signaling,cnaPRAD7,3,3,1.042073582329007,1.3024438168140848,2.9842727649724288,,,.27115329110800662,-1.6818289481583439,1.6614060871037866,1.5650047100379862,.34347151553580646,,.87771345337993312,0,PRAD,GDSC1
Fulvestrant,1414,ESR1,Hormone-related,cnaPRAD7,3,3,.5458724352609049,3.7525945135286034,3.2019760893747429,,,.55112272862055189,.55061842415386053,.66597739592378691,1.2615080519209534,.56544148398856831,,.95381852730669359,0,PRAD,GDSC1
AZD8931,1416,EGFR, ERBB2, ERBB3,RTK signaling,cnaPRAD7,3,3,.33412003345383134,1.543426147213909,1.7563894767032593,,,.70682588632346233,-.21296332948935026,.75963674562932648,.48525566579470131,.67162489499610656,,.82880380790193209,0,PRAD,GDSC1
FEN1_3940,1419,FEN1,Genome integrity,cnaPRAD7,3,3,.75437022732638936,2.0042772886879336,2.6264231165692618,,,.42216831967911617,-.62214582788132811,1.0262904667351864,.55413093467461971,.34090709714009443,,.64289425493295704,0,PRAD,GDSC1
FGFR_0939,1421,FGFR4,RTK signaling,cnaPRAD7,3,3,1.0134450881838535,1.5561718452477653,2.2307502477916192,,,.33319104192673471,-.67457840254385393,.9250234801665338,.17451473414751564,.25101588156071419,,.70825318144316574,0,PRAD,GDSC1
FGFR_3831,1422,FGFR1, FGFR2, FGFR3, FGFR4,RTK signaling,cnaPRAD7,3,3,.45129847910244592,2.4925075723307955,3.1185714051777693,,,.63539966836759376,-.62606383284697387,1.9560046804864899,.15156197642047969,.33148623516558967,,.28295267962039217,0,PRAD,GDSC1
BPTES,1425,GLS,Other,cnaPRAD7,3,3,.60052654301671915,2.9763457416538235,3.8946462962603525,,,.52382076363653629,-.91830055460652904,2.025528722624077,.75755379481629281,.80177781274150917,,.15246125346615808,0,PRAD,GDSC1
AZD5582,1427,IAP,Other,cnaPRAD7,3,3,.090776757058632529,3.0900318067812234,3.1552228243473586,,,.91896387396405954,-.065191017566135212,.42161402129792708,.92396462914386435,.3860352175035528,,.038359773535744421,0,PRAD,GDSC1
IAP_5620,1428,IAP,Other,cnaPRAD7,3,3,1.619519859751992,4.687999121060237,4.0386016776934204,,,.13188430820347927,.6493974433668166,.30017446113768897,.48111075737259035,.20880567373058442,,.56507948573208411,0,PRAD,GDSC1
IGFR_3801,1430,IGFR1,IGF1R signaling,cnaPRAD7,3,3,.95257210338055442,-.52112951904598181,.81316946615595775,,,.31070376297721797,-1.3342989852019396,1.2480014846855725,1.5383747991048926,.16910769900923073,,.3831594194890095,0,PRAD,GDSC1
AZD1480,1432,JAK1, JAK2,Other, kinases,cnaPRAD7,3,3,.84956632486682848,1.2386429887208106,2.5780478340225521,,,.3899359429516181,-1.3394048453017415,2.1139502286140623,.70879512651858612,.30484779208188628,,.66747034567112229,0,PRAD,GDSC1
JAK1_3715,1433,JAK1,Other, kinases,cnaPRAD7,3,3,.70945536777273888,4.3665396605150635,3.8816663782497769,,,.47136168872817258,.48487328226528659,.1766626034799417,.95025404976187455,.1829200021852638,,.23791192038806919,0,PRAD,GDSC1
JAK3_7406,1434,JAK3,Other, kinases,cnaPRAD7,3,3,.67319059096925427,2.4507828525556601,2.8397408569135898,,,.47475194614158683,-.38895800435792971,.74629729191431637,.33272584096133573,.42766567898670976,,.77080119161524763,0,PRAD,GDSC1
MCT1_6447,1436,MCT1,Cell cycle,cnaPRAD7,3,3,.57707607424484009,4.1783063009177406,4.6095515754354155,,,.53167262044065411,-.43124527451767491,.94582708844803076,.47149407071370297,.71511542755814261,,.47043841804337527,0,PRAD,GDSC1
MCT4_1422,1437,MCT4,Other,cnaPRAD7,3,3,.74760620259560018,4.7712104053889712,4.4593546803242559,,,.44585508042557248,.31185572506471537,.15334081630698498,.56964597100312231,.32878528341444896,,.59984250169717479,0,PRAD,GDSC1
AZD2014,1441,mTORC1, mTORC2,PI3K/MTOR signaling,cnaPRAD7,3,3,.2371490378639895,.1440379634854283,-.2004499677738211,,,.78609578040554806,.34448793125924937,1.3655097665594047,1.5347980179553142,.24133164329563694,,.078669146443941629,0,PRAD,GDSC1
AZD8186,1444,PI3Kbeta, PI3Kdelta,PI3K/MTOR signaling,cnaPRAD7,3,3,.057436924686077376,.42195987158154818,.53990086404161641,,,.94731001741226906,-.11794099246006823,1.9822809905573615,2.1221373216129038,.54054935643092095,,.10930290867551318,0,PRAD,GDSC1
AZD8835,1445,PI3Kalpha, PI3Kdelta,PI3K/MTOR signaling,cnaPRAD7,3,3,1.0483884630423947,2.2997118124484595,2.7270270155987792,,,.28398384427669982,-.42731520315031979,.28927265531523627,.49858250255237496,.42610688772628008,,.43657874978659716,0,PRAD,GDSC1
PI3Ka_4409,1446,PI3Kalpha, PI3Kdelta,PI3K/MTOR signaling,cnaPRAD7,3,3,.97463999669195334,2.0249106848490048,2.9622405382737664,,,.33005102446333273,-.93732985342476161,1.2662211813070898,.49647858870335537,.48527061625106227,,.28230019490157132,0,PRAD,GDSC1
AZD1208,1449,PIM1, PIM2, PIM3,Other, kinases,cnaPRAD7,3,3,.35380139975783459,3.6517978785112191,3.5001849639051845,,,.68717718981266351,.15161291460603454,.41815193692273817,.43865377169773012,.51726463029444747,,.49359746742652,0,PRAD,GDSC1
PLK_6522,1451,PLK1, PLK2, PLK3,Cell cycle,cnaPRAD7,3,3,.30255841320525406,-3.4072990167943282,-3.0474355096168178,,,.73055817787769617,-.35986350717751048,1.0556189355386891,1.3095883799869557,.72733764745910912,,.91825205198134086,0,PRAD,GDSC1
RAF_9304,1453,ARAF, BRAF, CRAF,ERK MAPK signaling,cnaPRAD7,3,3,.18508170891473916,2.8240124847271133,2.9748475557827678,,,.83443089561914086,-.15083507105565452,.99941293736038672,.57402866718673562,.56106282815084563,,.055513153667264697,0,PRAD,GDSC1
PARP_9495,1458,PARP1, PARP2, PARP7,Genome integrity,cnaPRAD7,3,3,.56910031552002416,1.4669622820128183,2.295502807070672,,,.54711336780475772,-.82854052505785369,1.961335556527283,.62635714350764227,.63362202090220809,,.76982932021425243,0,PRAD,GDSC1
PARP_0108,1459,PARP1, PARP2, PARP6,Genome integrity,cnaPRAD7,3,3,.36877523549889946,-.52724586316367461,-.060967333207539109,,,.6788640070606824,-.4662785299561355,.95985065981635243,1.5086713996355037,.9322029283180775,,.13643144624837988,93.220292831807754,PRAD,GDSC1
PARP_9482,1460,PARP1, PARP2, PARP5a,Genome integrity,cnaPRAD7,3,3,.59209933394916436,-1.279952468282753,-.33092302079838726,,,.51291731463219481,-.94902944748436568,1.2985659974177504,1.8579017310590324,.81606498985117348,,.1392115996935066,0,PRAD,GDSC1
TANK_1366,1461,Tankyrase 1/2 (PARP5a, PARP5b),Genome integrity,cnaPRAD7,3,3,.57603025634473193,2.0892360424706786,2.7444433619820132,,,.54699030817451411,-.6552073195113346,1.564440488811516,.37433197100305637,.74918290602005544,,.36266226708742672,0,PRAD,GDSC1
AZD1332,1463,NTRK1, NTRK2, NTRK3,RTK signaling,cnaPRAD7,3,3,.69885445259845502,1.1681505449962237,2.1593375477349226,,,.47920465034742732,-.99118700273869886,1.985951143916193,.28135724468488466,.27526943977751744,,.41122536499347317,0,PRAD,GDSC1
TTK_3146,1464,TTK,Mitosis,cnaPRAD7,3,3,1.4388792112793654,2.7079308796817223,3.309669701674224,,,.16923877808190249,-.60173882199250173,.30098655359378801,.50910611362610581,.2693983172445405,,.45898753227012956,0,PRAD,GDSC1
SN-38,1490,TOP1,DNA replication,cnaPRAD7,3,3,3.2656216354025482,-5.3413006657331872,-3.7309782791331823,,,.016161536022940976,-1.6103223866000049,.50004137572460206,.48608706503385635,.03681168025727044,,.53302680796721613,0,PRAD,GDSC1
SN-38,1494,TOP1,DNA replication,cnaPRAD7,3,3,.50641396793196347,-4.4779609138473404,-3.6929455661738877,,,.58039643316986511,-.78501534767345271,1.9700571853519364,.96165326495351411,.42818726652071493,,.51921096867489458,0,PRAD,GDSC1
Olaparib,1495,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,1.2752976054653642,3.141024642186697,3.9873088681590243,,,.20171161658886971,-.84628422597232733,.77001565096418068,.53646903125298817,.29295968181451437,,.67699101847431775,58.591936362902871,PRAD,GDSC1
Cisplatin,1496,DNA crosslinker,DNA replication,cnaPRAD7,3,3,1.3643861057692661,1.7040865892237955,2.442869496335272,,,.17254452840155399,-.73878290711147643,.48803045330913947,.59010143902161127,.30236598839540568,,.35208714665385116,0,PRAD,GDSC1
AZD4547,1497,FGFR1, FGFR2, FGFR3,RTK signaling,cnaPRAD7,3,3,.88786968360567631,1.2947204636515817,2.2914567015373897,,,.37310998607473028,-.99673623788580801,1.5091415032253723,.49297351713212018,.11368098521018077,,.20455258615552971,0,PRAD,GDSC1
Selumetinib,1498,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,1.4961114705498222,1.9954026087093222,3.567930424177169,,,.20703299438941358,-1.5725278154678468,1.4825230610416777,.10793319225014196,.24387648283054067,,.53809779750391795,0,PRAD,GDSC1
Bicalutamide,1502,AR,Hormone-related,cnaPRAD7,3,3,1.1178345035358486,4.5772997143450675,3.6879490653146956,,,.27683940853642219,.88935064903037198,.41391119270339205,1.0462507186387189,.20120000159407528,,.65377202424592662,0,PRAD,GDSC1
Refametinib,1526,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,2.0970907131148215,2.104552852418879,4.1341098765854012,,,.12356804531663806,-2.0295570241665222,1.3674272122182702,.058334364751758967,.12235022243220688,,.14199306280441906,0,PRAD,GDSC1
Pictilisib,1527,PI3K (class 1),PI3K/MTOR signaling,cnaPRAD7,3,3,.059424589966276489,.43714390933601899,.50337965761367187,,,.94756651644881718,-.066235748277652884,1.4990346700660662,.48748736396431802,.67599869906926779,,.21573163193957332,0,PRAD,GDSC1
PFI-3,1530,SMARCA2, SMARCA4, PB1,Chromatin other,cnaPRAD7,3,3,1.2209680040708841,4.3046553456932726,4.7861596611196822,,,.2091995875265697,-.48150431542640959,.40010115260370877,.38853963133388797,.30984349553632518,,.69208674229869538,0,PRAD,GDSC1