drug_name,drug_id,drug_target,target_pathway,feature_name,n_feature_pos,n_feature_neg,ic50_effect_size,log_ic50_mean_pos,log_ic50_mean_neg,log_max_conc_tested,log_max_conc_tested_2,feature_ic50_t_pval,feature_delta_mean_ic50,feature_pos_ic50_var,feature_neg_ic50_var,feature_pval,tissue_pval,msi_pval,fdr,tissue_type,screening set
Camptothecin,1003,TOP1,DNA replication,cnaPRAD7,3,3,1.2759729291822313,-3.3824955781306123,-2.1817118600225651,,,.23818910796520706,-1.2007837181080472,.39944444022577907,1.2695200103668709,.337270830742397,,.30660820219098739,0,PRAD,GDSC2
Vinblastine,1004,Microtubule destabiliser,Mitosis,cnaPRAD7,3,3,2.3640703998954877,-4.4864672081135639,-2.8603476207158676,,,.062739097730064738,-1.6261195873976964,.44716643855582361,.8638924482677226,.10456661564240494,,.23713693837789337,20.913323128480986,PRAD,GDSC2
Cisplatin,1005,DNA crosslinker,DNA replication,cnaPRAD7,3,3,1.277792693971803,2.9557989719132824,4.3683043981861873,,,.2189209463871685,-1.4125054262729049,.68192522626510343,1.4067380074220071,.29341097147827705,,.66912573053842284,58.682194295655407,PRAD,GDSC2
Cytarabine,1006,Antimetabolite,Other,cnaPRAD7,3,3,.75801928786004058,3.0527982868084602,1.7761671808765624,,,.41525816277749189,1.2766311059318978,1.2562977809884817,2.0235002280198429,.51622939859933759,,.75707466320200245,0,PRAD,GDSC2
Docetaxel,1007,Microtubule stabiliser,Mitosis,cnaPRAD7,3,3,.61359949329557428,-4.6712955721063194,-3.979964624928753,,,.49855012729270759,-.69133094717756638,.91793478759416858,1.3023886869966399,.62515315369463109,,.69299851568344162,0,PRAD,GDSC2
Gefitinib,1010,EGFR,EGFR signaling,cnaPRAD7,3,3,1.6282076532628218,3.6099590738538012,4.4939339181831954,,,.124702703500254,-.88397484432939422,.62688470978371325,.44331057799638995,.14275829289997422,,.98415137370404027,28.551658579994843,PRAD,GDSC2
Navitoclax,1011,BCL2, BCL-XL, BCL-W,Apoptosis regulation,cnaPRAD7,3,3,.088124555562349133,3.2701498083371576,3.1572650687621988,,,.9216075111476939,.11288473957495881,.7006575390543287,1.670579921142143,.69497488349909309,,.43512602304812881,0,PRAD,GDSC2
Vorinostat,1012,HDAC inhibitor Class I, IIa, IIb, IV,Chromatin histone acetylation,cnaPRAD7,3,3,.022388797858197744,1.5379799394215727,1.5145666435864189,,,.97979339571672996,.023413295835153836,.71086836415823884,1.2968776418760408,.78569150156826173,,.50154935165976544,0,PRAD,GDSC2
Nilotinib,1013,ABL,ABL signaling,cnaPRAD7,3,3,.077670207153156007,3.8691474351188684,3.7389430711874083,,,.92973399283195546,.13020436393146007,1.22181009850359,2.0316603580056154,.84704222862720158,,.75565418149113928,0,PRAD,GDSC2
Olaparib,1017,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,.32509787663067363,4.7105188541203926,4.3100937427182515,,,.71116351941410527,.4004251114021411,1.15017298082928,1.3081678271615915,.79668270508360439,,.82468681776466868,0,PRAD,GDSC2
AZD7762,1022,CHEK1, CHEK2,Cell cycle,cnaPRAD7,3,3,.98103798610492976,.5961293004621433,1.9553477186765684,,,.29798884334601383,-1.3592184182144251,1.5101852277009522,1.2484014645225576,.37188485074307981,,.87106762812750205,0,PRAD,GDSC2
Afatinib,1032,ERBB2, EGFR,EGFR signaling,cnaPRAD7,3,3,.17733124383153984,2.6179872474244799,2.8577686245353995,,,.84324042512303166,-.23978137711091962,.76485038514702997,1.7526302161737126,.96870129811096584,,.51860075375383541,96.870129811096589,PRAD,GDSC2
Staurosporine,1034,Broad spectrum kinase inhibitor,RTK signaling,cnaPRAD7,3,3,.62813677042226146,-2.4120522386700007,-1.6168124700695408,,,.48625045838798375,-.79523976860045997,1.1313104531862479,1.3877315127067518,.57570770176202879,,.83420188978305521,0,PRAD,GDSC2
PLX-4720,1036,BRAF,ERK MAPK signaling,cnaPRAD7,3,3,.68117659340743908,5.2333008366427052,5.7465614477894711,,,.45401533487854179,-.51326061114676591,.84588691448229136,.64805361840447884,.53442692060629182,,.86201259863721935,0,PRAD,GDSC2
Wee1 Inhibitor,1046,WEE1, CHEK1,Cell cycle,cnaPRAD7,3,3,.3115681303867332,2.9621185085592834,3.389977545107429,,,.72321810335187031,-.42785903654814561,1.5286031389042141,1.1979023740803811,.75580441122117903,,.97866192293406107,0,PRAD,GDSC2
Nutlin-3a (-),1047,MDM2,p53 pathway,cnaPRAD7,3,3,.05449351838530786,4.4195614225996431,4.2807858981416667,,,.95074471971057883,.13877552445797647,1.7989361539063196,3.1200332501669461,.64178891036314234,,.30350427196188923,0,PRAD,GDSC2
Mirin,1048,MRE11,Genome integrity,cnaPRAD7,3,3,4.9550447332944909,4.5854229133804667,5.738705356554707,,,.020769454873774209,-1.1532824431742403,.071234888885511619,.32135638004526973,.0040612087849108171,,.47855157950934846,0,PRAD,GDSC2
PD173074,1049,FGFR1, FGFR2, FGFR3,RTK signaling,cnaPRAD7,3,3,.58702927715881226,4.5009819354660845,4.9367810426821448,,,.51846931173706878,-.4357991072160603,.88493585356351856,.56493030045112702,.46752574969682337,,.74047217589791847,0,PRAD,GDSC2
Alisertib,1051,AURKA,Mitosis,cnaPRAD7,3,3,.42011006294750319,2.907845958019005,3.7198509036429095,,,.63401223015457786,-.81200494562390446,1.9187112416152228,1.9468634449473645,.45201188729639874,,.45449846747162265,0,PRAD,GDSC2
MK-2206,1053,AKT1, AKT2,PI3K/MTOR signaling,cnaPRAD7,3,3,.77752185603994672,3.8557157544309391,1.9130811019651308,,,.40526273526765594,1.9426346524658082,1.839210199522012,3.016995644866745,.28355717985311868,,.516008100035933,0,PRAD,GDSC2
Palbociclib,1054,CDK4, CDK6,Cell cycle,cnaPRAD7,3,3,.350145252215461,4.3409851897835834,3.6589703949959786,,,.69598739795041609,.68201479478760474,1.330365477589017,2.4120570147121136,.42156719390457842,,.32179556437632489,0,PRAD,GDSC2
Dactolisib,1057,PI3K (class 1), MTORC1, MTORC2,PI3K/MTOR signaling,cnaPRAD7,3,3,.3430639583540066,-.99358619237400603,-1.6260382174826751,,,.69608006306559211,.63245202510866905,1.9148529671649686,1.7693544945387771,.55423745158561366,,.55484790952427754,0,PRAD,GDSC2
Pictilisib,1058,PI3K (class 1),PI3K/MTOR signaling,cnaPRAD7,3,3,.76837626544287885,1.7994466200126322,.75508921234723181,,,.41224336452152938,1.0443574076654003,.95893985241347668,1.665876607024007,.30739372607798193,,.56837737682319478,0,PRAD,GDSC2
PD0325901,1060,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,1.3296713793864003,1.2241263793150547,2.6722580616822085,,,.17901471743862721,-1.4481316823671537,1.0552238551250601,1.1219341682731752,.28518750057072284,,.60958194635858842,0,PRAD,GDSC2
Obatoclax Mesylate,1068,BCL2, BCL-XL, BCL-W, MCL1,Apoptosis regulation,cnaPRAD7,3,3,.25930316588377966,1.4884388577249725,1.6246988301403888,,,.76840306685730919,-.13625997241541632,.60782791208655951,.4275682298657702,.67944071290619246,,.70040393247693544,0,PRAD,GDSC2
5-Fluorouracil,1073,Antimetabolite (DNA & RNA),Other,cnaPRAD7,3,3,.21850943138346557,4.3474673619224697,4.7090332833729383,,,.8028741007273521,-.36156592145046851,1.8331701610999265,1.4544764781885711,.98309209142371867,,.46782208955744314,98.30920914237187,PRAD,GDSC2
Dasatinib,1079,ABL, SRC, Ephrins, PDGFR, KIT,Other, kinases,cnaPRAD7,3,3,.66863898890515439,1.69941584153003,2.6356053709781384,,,.49758396829365487,-.9361895294481084,1.9713177791348229,.1862832233199892,.40480516133115546,,.69722461609354536,0,PRAD,GDSC2
Paclitaxel,1080,Microtubule stabiliser,Mitosis,cnaPRAD7,3,3,.22367744311021209,-2.2299888618341459,-1.7436618160397439,,,.79776822168580941,-.486327045794402,2.2576126398941612,2.087527236332992,.83027968800324259,,.96258358846461967,0,PRAD,GDSC2
Crizotinib,1083,MET, ALK, ROS1,RTK signaling,cnaPRAD7,3,3,.054718879054136041,3.9308938613582751,3.8704546131452831,,,.95064185413326974,.060439248212992069,.75421536467278927,1.367911200715878,.69302788213476707,,.38149320914776258,0,PRAD,GDSC2
Rapamycin,1084,MTORC1,PI3K/MTOR signaling,cnaPRAD7,3,3,.036767172985524746,-2.8726399446758601,-2.7889330702693118,,,.96673236320470179,-.083706874406548337,1.6220870704256412,2.7812451217226877,.75396197801730958,,.34716904083389644,0,PRAD,GDSC2
Sorafenib,1085,PDGFR, KIT, VEGFR, RAF,Other, kinases,cnaPRAD7,3,3,.41716659293068847,3.3300595299396769,2.9006585902776005,,,.63955841275551883,.42940093966207638,.82450198897061688,1.1996772996718548,.6064930320183699,,.81578995442655289,0,PRAD,GDSC2
Irinotecan,1088,TOP1,DNA replication,cnaPRAD7,3,3,.91148844999227074,1.9656027853827587,2.750899454594721,,,.36011291892459685,-.78529666921196228,.40770750017720297,1.1481836735091711,.51645078314273896,,.33462452656525205,0,PRAD,GDSC2
Oxaliplatin,1089,DNA alkylating agent,DNA replication,cnaPRAD7,3,3,.18389284838762171,4.1869173977163339,3.7863809798191812,,,.83434538606213215,.40053641789715266,1.7155560847786586,2.5583350722684433,.71698048686023386,,.64738465017001368,0,PRAD,GDSC2
BMS-536924,1091,IGF1R, IR,IGF1R signaling,cnaPRAD7,3,3,.35886070136460757,2.3505446327703643,2.8767414686405473,,,.68651753302531682,-.52619683587018296,1.7391140446054754,1.1293997260566084,.52558451407196849,,.51799053559741814,0,PRAD,GDSC2
GSK1904529A,1093,IGF1R, IR,IGF1R signaling,cnaPRAD7,3,3,.53310231251495721,4.5534099870620741,4.023002651170529,,,.56701239737396203,.5304073358915451,.51055875563620312,1.3111673367079335,.38101143022139061,,.45296899385307582,0,PRAD,GDSC2
PRIMA-1MET,1131,TP53 activation,p53 pathway,cnaPRAD7,3,3,.913817105302691,4.3661772126560541,6.0412916400635082,,,.33011413773620968,-1.6751144274074541,2.0704275663311846,1.5600676771549464,.43288816884463477,,.74748035549561265,0,PRAD,GDSC2
Erlotinib,1168,EGFR,EGFR signaling,cnaPRAD7,3,3,2.1822121248501092,3.1063851884553535,4.2124987310091635,,,.11315427025065271,-1.10611354255381,.71239102061767134,.07967432754311421,.051474178729099332,,.81848199979073311,0,PRAD,GDSC2
Niraparib,1177,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,.48264989266576025,4.265882642312504,4.8374104480697993,,,.58671513104730244,-.57152780575729523,1.2575752398201758,1.105851119889989,.74692769255081459,,.60140177153033181,0,PRAD,GDSC2
MK-1775,1179,WEE1, PLK1,Cell cycle,cnaPRAD7,3,3,.16226735208023441,1.8180016551047424,2.021584132668286,,,.85290953394941937,-.20358247756354353,1.4224656707620904,1.060514585767794,.82083403135159394,,.87076830205123057,0,PRAD,GDSC2
Dinaciclib,1180,CDK1, CDK2, CDK5, CDK9,Cell cycle,cnaPRAD7,3,3,.89192867169397627,-1.5516588842364358,-2.5253364530499836,,,.33778988303161761,.97367756881354772,1.1834541286559781,.99138971301343781,.4503453349067324,,.72076017624945443,0,PRAD,GDSC2
Gemcitabine,1190,Pyrimidine antimetabolite,DNA replication,cnaPRAD7,3,3,2.5945599496137626,-2.5810754143340362,.67737078379318483,,,.08078405698551594,-3.258446198127221,.28574759882592565,1.7529399813446787,.073441402194065725,,.12416391447774221,0,PRAD,GDSC2
Bortezomib,1191,Proteasome,Protein stability and degradation,cnaPRAD7,3,3,.49812055370022085,-4.6321852173225952,-4.2340690825718612,,,.58206174943446021,-.39811613475073404,.97486825372926567,.57200515521421103,.59976860177773073,,.96091067520984408,0,PRAD,GDSC2
Tamoxifen,1199,ESR1,Hormone-related,cnaPRAD7,3,3,.07742477491093383,3.8113395473934637,3.9201136098407487,,,.93020115379169677,-.10877406244728505,.96581952914185909,1.7362834962925962,.97148686190839362,,.74189746130779488,97.148686190839356,PRAD,GDSC2
Fulvestrant,1200,ESR,Hormone-related,cnaPRAD7,3,3,.59153287809642863,3.188898772294031,2.6775504467680835,,,.51051492464931991,.51134832552594744,.76902916808673338,.95033071552804693,.56194135380786725,,.96170743000088743,0,PRAD,GDSC2
EPZ004777,1237,DOT1L,Chromatin histone methylation,cnaPRAD7,3,3,.067491868114367332,5.2194425945672096,5.1416181178602489,,,.93887978291914087,.077824476706960688,.848001270421324,1.3928912284701533,.95963169191947173,,.95638267790072196,95.963169191947173,PRAD,GDSC2
YK-4-279,1239,RNA helicase A,Other,cnaPRAD7,3,3,.070104825105466381,2.6716959532827786,2.7408485137401191,,,.93679705269779601,-.069152560457340417,.6746637354438233,1.2210094618252045,.90899859915541859,,.59833091360361945,90.899859915541853,PRAD,GDSC2
BMS-345541,1249,IKK-1, IKK-2,Other,cnaPRAD7,3,3,.89224225393501611,3.1737751198317312,3.8518041340480083,,,.34211837774664433,-.67802901421627704,.87702782858650907,.62110090124996664,.43365591057030839,,.7914363892621441,86.731182114061681,PRAD,GDSC2
AZ960,1250,JAK2, JAK3,Other, kinases,cnaPRAD7,3,3,.052832549001417761,2.5590071022598009,2.6367844477910527,,,.95248065003370574,-.077777345531251818,1.849347829305878,.95621841383410933,.47946422642429293,,.13807390472380648,0,PRAD,GDSC2
Talazoparib,1259,PARP1, PARP2,Genome integrity,cnaPRAD7,3,3,.1890440253791468,2.7546477684265951,2.9852259033414206,,,.83699285875686913,-.23057813491482548,.34040049213700313,1.691003557819279,.78459282688732068,,.19053851057872676,0,PRAD,GDSC2
XAV939,1268,TNKS1, TNKS2,WNT signaling,cnaPRAD7,3,3,.48899399054367998,4.5510142158818176,5.1384519902103811,,,.58154048407308512,-.58743777432856348,1.2199210154400961,1.1824243828614132,.6330458420989169,,.95481047645336892,0,PRAD,GDSC2
Trametinib,1372,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,2.1225511308032314,1.4515787691998796,3.4606634727325383,,,.087479831580260611,-2.0090847035326584,1.2228988157446492,.5444296347062908,.089914936548379717,,.85347392315008475,0,PRAD,GDSC2
Dabrafenib,1373,BRAF,ERK MAPK signaling,cnaPRAD7,3,3,.86326093714517416,5.5255683802211459,4.7318293607172661,,,.37666035165108031,.79373901950387982,.49730405704726671,1.2014673794436945,.45531220126662625,,.76423981373197147,0,PRAD,GDSC2
Temozolomide,1375,DNA alkylating agent,DNA replication,cnaPRAD7,3,3,.64188318853718507,6.267199577556827,5.5867330693235244,,,.50092844938207015,.68046650823330257,.47457730430741829,1.4221255095221075,.34896072549638479,,.51521227968671912,0,PRAD,GDSC2
AZD5438,1401,CDK2,Cell cycle,cnaPRAD7,3,3,.93333827312099871,3.0452955371160706,2.5162100561533634,,,.32096837579606763,.52908548096270724,.48517959980794195,.63819566097724634,.16550564835211543,,.35786355002306552,0,PRAD,GDSC2
IAP_5620,1428,IAP,Other,cnaPRAD7,3,3,.23705081346145798,5.6360388117161726,5.8296044379808754,,,.7873750426041537,-.19356562626470275,.93746284035384009,.67431136444424533,.75012646181461773,,.84008715140609458,0,PRAD,GDSC2
AZD2014,1441,mTORC1, mTORC2,PI3K/MTOR signaling,cnaPRAD7,3,3,.084132479178553002,1.320773976602668,1.1809539792905297,,,.9229187702558671,.13981999731213834,1.7257460747655975,1.5955067820625592,.71558891534651636,,.46741334560106218,0,PRAD,GDSC2
AZD1208,1449,PIM1, PIM2, PIM3,Other, kinases,cnaPRAD7,3,3,.73122608161975611,5.4886942003007215,5.1144538023616155,,,.43929203172317055,.37424039793910602,.65331443044576976,.31153751869557172,.52160638541102178,,.79754984502069848,0,PRAD,GDSC2
AZD1332,1463,NTRK1, NTRK2, NTRK3,RTK signaling,cnaPRAD7,3,3,.61645305447449528,3.3798799023497352,4.6531149389730047,,,.52324901429511173,-1.2732350366232694,2.8562482593296536,.6113698206414846,.21331917695622063,,.22920980265427893,0,PRAD,GDSC2
Ruxolitinib,1507,JAK1, JAK2,Other, kinases,cnaPRAD7,3,3,.50391247810146012,5.5311573063545723,5.1780311998643702,,,.5714974343746968,.35312610649020204,.7599027688132951,.63616146007090524,.79951409395394701,,.38982717646017073,0,PRAD,GDSC2
Linsitinib,1510,IGF1R,IGF1R signaling,cnaPRAD7,3,3,.38836273148491313,3.9808281976615127,3.2522729630478922,,,.66454336430678274,.72855523461362059,1.3489768249739729,2.2844600054163533,.80687701321843119,,.64357100141426182,0,PRAD,GDSC2
Epirubicin,1511,Anthracycline,DNA replication,cnaPRAD7,3,3,.27149675895854469,-1.2600385176062521,-.8850492668301424,,,.76395168256962631,-.37498925077610967,.7439893605043294,1.8060632694881924,.98044675451428631,,.44321856351259264,98.044675451428631,PRAD,GDSC2
Cyclophosphamide,1512,Alkylating agent,DNA replication,cnaPRAD7,3,3,.12072860326509639,5.3779284977830075,5.4255152697613065,,,.88969629130402361,-.04758677197829897,.41626287884818164,.37074851869458347,.95190863045585505,,.85374664627614549,95.190863045585502,PRAD,GDSC2
Pevonedistat,1529,NAE,Other,cnaPRAD7,3,3,.4369190712754093,1.2040428240850236,.38035153763058033,,,.63699280337310837,.82369128645444323,.86600813790528663,2.5215443004397802,.51908268145424519,,.62456277796074067,0,PRAD,GDSC2
Sapitinib,1549,EGFR, ERBB2, ERBB3,EGFR signaling,cnaPRAD7,3,3,.5480960690878719,5.2343397112556351,5.5386482479353703,,,.54228741624729404,-.30430853667973512,.45863126648101349,.63731791782954084,.67599482724055782,,.67528898112019931,0,PRAD,GDSC2
Uprosertib,1553,AKT1, AKT2, AKT3,PI3K/MTOR signaling,cnaPRAD7,3,3,1.0343317133147909,2.9231773183464469,.37511427634019084,,,.27441890060648733,2.5480630420062562,2.3576304465339448,2.5649791526844714,.22254820429227912,,.63339666302437136,0,PRAD,GDSC2
LCL161,1557,XIAP, IAP1, IAP2,Apoptosis regulation,cnaPRAD7,3,3,.2069027359704102,5.0686798311597805,5.2858012978364135,,,.81338366916781268,-.21712146667663301,.88961229535431285,1.1878656251804294,.80856239982707623,,.93654918111399921,0,PRAD,GDSC2
Lapatinib,1558,EGFR, ERBB2,EGFR signaling,cnaPRAD7,3,3,.7815493454798158,4.679341940880664,3.7066724596895355,,,.39481293041377613,.9726694811911285,1.1087764686748645,1.3668850500461851,.34574419008575086,,.69589464707938165,0,PRAD,GDSC2
Luminespib,1559,HSP90,Protein stability and degradation,cnaPRAD7,3,3,.948862273201593,-2.4471567942292709,-1.2277967032466062,,,.31007481902760664,-1.2193600909826647,1.3277323704523534,1.2409541360310532,.40165031531325496,,.80779301877743603,0,PRAD,GDSC2
Alpelisib,1560,PI3Kalpha,PI3K/MTOR signaling,cnaPRAD7,3,3,.013326018233891672,3.6650134280266262,3.6496107781706537,,,.9879117428877604,.015402649855972506,1.3939596538514736,.8536836150320487,.77817627300655023,,.47043181963355274,0,PRAD,GDSC2
Taselisib,1561,PI3K (beta sparing),PI3K/MTOR signaling,cnaPRAD7,3,3,.56347644393525442,2.4571735863386706,1.5443315666716189,,,.52853520279641231,.9128420196670517,1.7095202872230708,1.52527291468131,.50164815948296726,,.79604128345701852,0,PRAD,GDSC2
EPZ5676,1563,DOT1L,Chromatin histone methylation,cnaPRAD7,3,3,.15155603131285708,5.8020000685957607,5.9268413720398847,,,.8639988452767311,-.12484130344412403,.57518168742857512,1.0130298224911825,.88085806768557662,,.98439920281190929,0,PRAD,GDSC2
SCH772984,1564,ERK1, ERK2,ERK MAPK signaling,cnaPRAD7,3,3,1.2877955612807217,3.5628271452944502,5.103885365539675,,,.19196607811924279,-1.5410582202452248,1.2955968245461238,1.0887777370932281,.30308959657524831,,.58642454083138795,0,PRAD,GDSC2
IWP-2,1576,PORCN,WNT signaling,cnaPRAD7,3,3,.13656290012342845,3.3883454236105854,3.2910382690355147,,,.87833344754946241,.097307154575070776,.42992228216489475,.91137609896395133,.88460674624664459,,.99146332004441629,0,PRAD,GDSC2
Leflunomide,1578,Pyrimidine synthesis inhibitor,DNA replication,cnaPRAD7,3,3,.46411453656985585,5.3488310581596581,5.2151201084869969,,,.61424530808585642,.13371094967266117,.15455423152665634,.37698155970037195,.49710969484201495,,.61546646414353146,0,PRAD,GDSC2
Entinostat,1593,HDAC1, HDAC3,Chromatin histone acetylation,cnaPRAD7,3,3,.55818006871708725,2.8720363312997992,2.0467523018610598,,,.53346972242146007,.82528402943873935,1.3053609578159535,1.6334362725598726,.46648933825292105,,.6895577640828281,0,PRAD,GDSC2
LGK974,1598,PORCN,WNT signaling,cnaPRAD7,3,3,3.6192511955707318,4.6381753107449208,3.7877666194344122,,,.037860165206565717,.85040869131050867,.081273953017907449,.32220271619123803,.016086056606496285,,.72491396359248506,0,PRAD,GDSC2
VE-822,1613,ATR,Genome integrity,cnaPRAD7,3,3,.25979830340222465,3.8484547294760012,4.1812577681871259,,,.77913779512788839,-.33280303871112471,.29185414856166497,1.7879516229290842,.92770263747944803,,.28421143948141375,92.77026374794481,PRAD,GDSC2
WZ4003,1614,NUAK1, NUAK2,Other, kinases,cnaPRAD7,3,3,.17916236457792745,4.6900526306611381,4.4988103264229169,,,.83745278524715916,.19124230423822119,.95679703942623517,1.1676171093441925,.9796132862924497,,.64358494454058357,97.961328629244974,PRAD,GDSC2
CZC24832,1615,PI3Kgamma,PI3K/MTOR signaling,cnaPRAD7,3,3,1.7942437579440007,4.5357833830220828,5.8569141102749755,,,.11497130146994225,-1.3211307272528927,.92296614781543673,.48213748291614456,.13987459010306794,,.82401913846797348,27.974918020613586,PRAD,GDSC2
AZD5582,1617,XIAP, cIAP,Apoptosis regulation,cnaPRAD7,3,3,.65916256671947249,3.0433255454071628,2.3087852606370944,,,.46598066219985096,.73454028477006839,1.2053489181548571,1.0152352392413411,.59452836588315905,,.69369386230560792,0,PRAD,GDSC2
GSK2606414,1618,PERK,Metabolism,cnaPRAD7,3,3,.90367192703221266,3.6325319682861861,4.2590475914829788,,,.34001981819082244,-.62651562319679277,.53255525022656858,.82323405268015881,.50727104869843043,,.41709789337982883,0,PRAD,GDSC2
PFI3,1620,Polybromo 1, SMARCA4, SMARCA2,Chromatin other,cnaPRAD7,3,3,.96483863351421462,5.4563746225632421,5.9616682134908094,,,.30283813496225737,-.50529359092756732,.51594331174735297,.53135899043719237,.37050457372243328,,.90821713894502887,0,PRAD,GDSC2
PCI-34051,1621,HDAC8, HDAC6, HDAC1,Chromatin histone acetylation,cnaPRAD7,3,3,.092340713735333119,5.2009009516108122,5.1053313581601341,,,.91569591472770062,.09556959345067817,.90384850058462796,1.1512477399999168,.88750256318635645,,.50444674790724586,0,PRAD,GDSC2
Wnt-C59,1622,PORCN,WNT signaling,cnaPRAD7,3,3,.99639552354536309,4.1124959563720838,4.9531954553204391,,,.33697369342336958,-.84069949894835538,.26042965037318488,1.1644626565996941,.47449352676843531,,.25824399567442524,0,PRAD,GDSC2
I-BET-762,1624,BRD2, BRD3, BRD4,Chromatin other,cnaPRAD7,3,3,.31118074195556483,3.6072957279900528,2.8907429614908953,,,.72482103119795394,.71655276649915756,1.8464806149065665,2.6824002929516126,.67939094346785411,,.80304108895017223,0,PRAD,GDSC2
RVX-208,1625,BRD4,Chromatin other,cnaPRAD7,3,3,.16280912030441277,4.5278650190432863,4.7255008817040585,,,.85510401591697793,-.19763586266077215,.75269003440117122,1.5429257754234202,.86677906280504702,,.99854338027104583,0,PRAD,GDSC2
OTX015,1626,BRD2, BRD3, BRD4,Chromatin other,cnaPRAD7,3,3,.57101893705821871,2.8504684754104219,1.6025190332377317,,,.53944879188403516,1.2479494421726902,1.2221534609273881,2.8388326643236566,.55749897320849107,,.98067276044272156,0,PRAD,GDSC2
GSK343,1627,EZH2,Chromatin histone methylation,cnaPRAD7,3,3,.2449318938869372,2.886027382946406,3.1634301183391305,,,.7791528213271891,-.27740273539272442,1.1517433839605227,1.113068220103911,.74130605454035814,,.83285603142077691,0,PRAD,GDSC2
ML323,1629,USP1, UAF1,Protein stability and degradation,cnaPRAD7,3,3,.6105927994818251,4.8375546430620462,4.3160297230104527,,,.49622882937121582,.52152492005159345,.87460643625235124,.83314808719874045,.20368410542620202,,.21115897743109818,0,PRAD,GDSC2
Entospletinib,1630,SYK,Other, kinases,cnaPRAD7,3,3,.31529168633043353,4.4178562691369496,4.0457185482856541,,,.72600478674690905,.37213772085129548,1.5012278320464159,.72973649753791003,.60417964439444216,,.023448752142765407,0,PRAD,GDSC2
PRT062607,1631,SYK,Other, kinases,cnaPRAD7,3,3,.27271548251093336,3.294048272995409,2.8697794582589644,,,.76192176971492431,.42426881473644462,2.004579346682509,.90674607208090618,.9493489967432871,,.5153677854402976,94.934899674328705,PRAD,GDSC2
AGI-6780,1634,IDH2 R140Q mutant,Metabolism,cnaPRAD7,3,3,.12737317598352135,4.7629174847788258,4.6484441438309716,,,.88495768633329852,.11447334094785422,1.0779784587825847,.67332934121203092,.9737730892513381,,.63706935718038382,97.377308925133804,PRAD,GDSC2
Picolinici-acid,1635,Inflammatory related,Other,cnaPRAD7,3,3,.035556445800136526,5.6055916687389606,5.6265509740044495,,,.96739572858881095,-.020959305265488837,.63161463370833559,.54406119225068039,.76201857368554515,,.47668905819347418,0,PRAD,GDSC2
AZD5153,1706,BRD4,Chromatin other,cnaPRAD7,3,3,.60896863221092468,1.622780752293244,.39227141669310051,,,.5036721789660733,1.2305093356001435,1.5524184053946388,2.3991682688171356,.54876519108749777,,.96831583408065469,0,PRAD,GDSC2
CDK9_5576,1708,CDK9,Cell cycle,cnaPRAD7,3,3,.42967887011254075,-.063229884560221231,-.46481275410332917,,,.63188423749792211,.40158286954310796,.69112373741717825,1.1266524666755244,.43943425142889042,,.44231674239878976,0,PRAD,GDSC2
CDK9_5038,1709,CDK9,Cell cycle,cnaPRAD7,3,3,.57674256232074528,-1.9229534084068776,-2.757890513813559,,,.51924397795885502,.83493710540668142,1.5127544793080852,1.3795335859307192,.51749984820009454,,.86752433455144884,0,PRAD,GDSC2
Eg5_9814,1712,KSP11,Other,cnaPRAD7,3,3,.015070200263324673,-3.5799364276001087,-3.5690686734190025,,,.98617832560983587,-.010867754181106193,.66285918067380412,.77505434713255239,.93529218989802543,,.85350575948485607,93.529218989802544,PRAD,GDSC2
ERK_2440,1713,ERK1,ERK2,ERK MAPK signaling,cnaPRAD7,3,3,1.7115175642689799,2.4095858409548256,4.395266445797346,,,.14826046817797808,-1.9856806048425204,1.5591364133460515,.51103999169255243,.15846482127168285,,.799262936056505,31.692964254336569,PRAD,GDSC2
ERK_6604,1714,ERK1,ERK2,ERK MAPK signaling,cnaPRAD7,3,3,1.9598402359571909,3.5285180845945536,5.1837971994840224,,,.12246885196410555,-1.6552791148894688,1.1532791119764707,.31087336843419427,.13326689558115495,,.65368379852345915,0,PRAD,GDSC2
IRAK4_4710,1716,IRAK4,Other, kinases,cnaPRAD7,3,3,.076161533406745238,5.2384513394891989,5.2981159703574967,,,.93023769527683797,-.059664630868297763,.83207777319937948,.73148121203659822,.97630264568606195,,.75771152264662267,97.630264568606194,PRAD,GDSC2
JAK1_8709,1718,JAK1,Other, kinases,cnaPRAD7,3,3,.28230490377568351,4.8509616317825666,4.6556189183788819,,,.74790225175941782,.1953427134036847,.7707002162592691,.60301639690388598,.80057489227712186,,.91343140114196097,0,PRAD,GDSC2
AZD5991,1720,MCL1,Apoptosis regulation,cnaPRAD7,3,3,.2178255205383961,4.4181782428377607,3.8046746081158993,,,.8138623638231135,.61350363472186142,.52715162812847982,3.9480824615701966,.95779127595695224,,.61465373540509816,95.779127595695229,PRAD,GDSC2
PAK_5339,1730,PAK1, PAK2,Cytoskeleton,cnaPRAD7,3,3,.36618370837975267,2.3207609714270845,1.9157076116722929,,,.67916638488676928,.40505335975479162,1.2673149448626226,.91708201493028185,.41556306051212921,,.32906237136130689,0,PRAD,GDSC2
TAF1_5496,1732,TAF1,Other,cnaPRAD7,3,3,.20429138738396452,3.7560198319275062,3.5568994549201203,,,.81877916639337589,.19912037700738594,1.2298567908529414,.62248367126523019,.49445170688438678,,.27534469258119121,92.55029813783085,PRAD,GDSC2
ULK1_4989,1733,ULK1,Other, kinases,cnaPRAD7,3,3,.55506131035933226,2.2430958205032892,3.0482640668387155,,,.53976879069011618,-.80516824633542639,1.114310275622201,1.7224269943719677,.61013730344043537,,.88175366034001612,94.750650984383512,PRAD,GDSC2
VSP34_8731,1734,VSP34,Other,cnaPRAD7,3,3,.56310227477058683,2.8524863572648997,2.4566706648967274,,,.54369893132306246,.39581569236817238,.40625939954165041,.90727369690495707,.07084550662560897,,.046871757961743948,0,PRAD,GDSC2
Selumetinib,1736,MEK1, MEK2,ERK MAPK signaling,cnaPRAD7,3,3,1.4948763942236349,4.781744494641722,6.4251049571863144,,,.18852012370858887,-1.6433604625445923,1.4871358773694894,.45329227362958063,.241591999656985,,.55966803996008208,48.318399931396996,PRAD,GDSC2
IGF1R_3801,1738,IGFR1,IGF1R signaling,cnaPRAD7,3,3,.37801098450371512,1.3367379841002727,2.2029755165950746,,,.66905260881386441,-.86623753249480195,1.9642768038015039,2.5776299408793184,.37583912654351515,,.28238513941843413,0,PRAD,GDSC2
JAK_8517,1739,JAK1, JAK2,Other, kinases,cnaPRAD7,3,3,.35270805634867897,2.786002015072246,3.5208472622299798,,,.70377310330686238,-.73484524715773381,2.8602072173341018,.70755892340658111,.4316547863630657,,.33985405339419339,0,PRAD,GDSC2
AZD4547,1786,FGFR1, FGFR2, FGFR3,RTK signaling,cnaPRAD7,3,3,.17992950925190043,3.0635166384531991,2.8485819568817612,,,.83920322962007721,.21493468157143791,1.4772285755804748,.81956825276070733,.62393137051668734,,.082092676489424352,0,PRAD,GDSC2
Ibrutinib,1799,BTK,Other, kinases,cnaPRAD7,3,3,1.2374372521753465,5.0204175155062094,5.9919244088899966,,,.22101280945060936,-.97150689338378715,.96004859390330044,.55772555210706665,.20901006126296037,,.83614412202951094,0,PRAD,GDSC2
Zoledronate,1802,,Unclassified,cnaPRAD7,3,3,1.4113288854905173,3.8219836466371202,4.2736738625047259,,,.21385525541046985,-.45169021586760572,.44100199098399906,.10186351057910326,.17635151606204832,,.90505625652975696,35.270303212409665,PRAD,GDSC2
Acetalax,1804,,Unclassified,cnaPRAD7,3,3,.58289535267842474,3.6527883480129417,1.8726039627410895,,,.5321043802887524,1.7801843852718522,3.9769772479219414,1.6846200103303557,.53872434071961495,,.94527964731896474,0,PRAD,GDSC2
Oxaliplatin,1806,DNA alkylating agent,DNA replication,cnaPRAD7,3,3,.035168865633791423,4.8097121489111858,4.878898749931925,,,.96800609545595995,-.069186601020739147,1.5346977641281476,2.3205588461212581,.80056265754371614,,.43089362838163098,0,PRAD,GDSC2
Carmustine,1807,,DNA replication,cnaPRAD7,3,3,.26112089265089544,6.3054604924909929,6.5298032126660077,,,.77190455983179451,-.22434272017501478,.4883148361067533,1.1125804904221073,.892903748709443,,.23002654790601776,0,PRAD,GDSC2
Topotecan,1808,,DNA replication,cnaPRAD7,3,3,.49843888568705497,-.56626506806790744,-.030286215731110715,,,.57891797848370952,-.53597885233679676,.84889693943422095,1.2617365203893491,.74629683171567263,,.5648185130917468,0,PRAD,GDSC2
Teniposide,1809,,DNA replication,cnaPRAD7,3,3,.50043491486392144,.0016217736720320157,.61020825395190048,,,.57486987209599505,-.6085864802798685,1.3543046745003344,1.0600617681771936,.5931627462017196,,.94547984322900702,0,PRAD,GDSC2
Mitoxantrone,1810,,DNA replication,cnaPRAD7,3,3,.27435290001090251,-.052803890881437589,-.49025203918760724,,,.7552267858826659,.43744814830616963,1.3297720777483022,1.8210961498390641,.70385389010551791,,.79337406914384057,0,PRAD,GDSC2
Dactinomycin,1811,,Other,cnaPRAD7,3,3,.22445402783218904,-2.7579408263397904,-2.3419302654265213,,,.79768668396672082,-.41601056091326916,1.6271745089531366,2.0549289108826487,.98070395914137054,,.4505449288681872,98.070395914137052,PRAD,GDSC2
Fludarabine,1813,,Unclassified,cnaPRAD7,3,3,2.4325370093283678,5.810628302583587,4.3647332602433915,,,.04890562613520022,1.4458950423401955,.46291487426149208,.70166066949687256,.088023417094377013,,.52705807068241317,0,PRAD,GDSC2
Nelarabine,1814,,DNA replication,cnaPRAD7,3,3,.804225616160687,6.2374409673433133,6.7124093474780544,,,.38287884060478966,-.47496838013474107,.52196028591220922,.65203744386182794,.47655986728718558,,.80861122385952322,0,PRAD,GDSC2
Fulvestrant,1816,,Hormone-related,cnaPRAD7,3,3,.44223809245958901,5.105553275345442,4.3460829347807151,,,.636187492528409,.75947034056472695,.63376013401912312,2.344529283337947,.38825539666741216,,.36412082681597735,0,PRAD,GDSC2
Vincristine,1818,,Mitosis,cnaPRAD7,3,3,.17255470500071723,-2.1949156038019288,-2.4103428592376335,,,.84553652285836189,.21542725543570462,.86811031943369521,1.5374257329183487,.90949459839189917,,.85306786486984953,90.949459839189913,PRAD,GDSC2
Docetaxel,1819,Microtubule stabiliser,Mitosis,cnaPRAD7,3,3,.49016031861862619,-3.3136700869446103,-2.6132234019409113,,,.58174536894177753,-.700446685003699,1.2862225128353169,1.5587822667531539,.48588089772195492,,.62949154767540849,92.288244058781814,PRAD,GDSC2
Podophyllotoxin bromide,1825,,Unclassified,cnaPRAD7,3,3,.95245842261748914,-.36372166113093884,-.70400175525986641,,,.35243645870387452,.34028009412892757,.12100433360717344,.49054517159075928,.36659695133690928,,.94764125472305571,0,PRAD,GDSC2
Dihydrorotenone,1827,,Unclassified,cnaPRAD7,3,3,1.0043542935234582,.88328427144946975,1.8419149118983726,,,.29370200715908296,-.95863064044890289,1.1096051742288038,.76864803215029109,.46736500904928474,,.15113400407408714,0,PRAD,GDSC2
Gallibiscoquinazole,1830,,Unclassified,cnaPRAD7,3,3,.24211609736599954,2.7974349605047095,3.0112936206081478,,,.78168234527012537,-.21385866010343824,.84556192015114695,.91947077267600397,.84906830186900883,,.86460633379037233,0,PRAD,GDSC2
Elephantin,1835,,Unclassified,cnaPRAD7,3,3,.46067682942374222,3.5490781076051898,3.1639457683527268,,,.60422120291222559,.38513233925246304,.92646712118435215,.73450522669690321,.77156504225991551,,.57746847566462012,0,PRAD,GDSC2
Sinularin,1838,,Unclassified,cnaPRAD7,3,3,.60821902315935628,3.5800732529045329,4.2980298698871024,,,.50482679176790302,-.71795661698256952,1.4118965580720892,.89070307045295694,.50625944612416651,,.89331114427311242,0,PRAD,GDSC2
Sabutoclax,1849,BCL2,  BCL-XL,  BFL1, MCL1,Apoptosis regulation,cnaPRAD7,3,3,.53323970982434754,-.11716793380007207,-.86078076642057511,,,.54943994140920149,.74361283262050304,1.3556238654590524,1.4323580701258807,.54297961327762911,,.86018843123101008,0,PRAD,GDSC2
LY2109761,1852,TGFB1,Other,cnaPRAD7,3,3,.68585839201262688,5.1154964604535289,5.786772597956003,,,.4518932155790289,-.67127613750247406,1.1118639338235632,.82438910805040544,.46842508545288208,,.92079587277137709,0,PRAD,GDSC2
OF-1,1853,BRPF1B, BRPF2,Chromatin histone acetylation,cnaPRAD7,3,3,1.2856855538810401,3.5271355326673306,4.9446815438024174,,,.1910682854831392,-1.4175460111350868,1.0500146284398395,1.1527134349418204,.26165148376904057,,.8329178699544314,0,PRAD,GDSC2
MN-64,1854,TNKS1, TNKS2,WNT signaling,cnaPRAD7,3,3,.48002514556539949,5.0822589209394868,4.5611861951668535,,,.59074859858440076,.52107272577263331,1.2348555816595803,.91203142016406025,.73420862737502324,,.64850845578365146,0,PRAD,GDSC2
KRAS (G12C) Inhibitor-12,1855,KRAS (G12C),ERK MAPK signaling,cnaPRAD7,3,3,.635659347953621,4.981223111203307,3.6623607949219239,,,.47980503444247086,1.3188623162813831,2.0348620769045875,2.1139721179896478,.38508931979223776,,.59560075226655051,0,PRAD,GDSC2
MG-132,1862,Proteasome, CAPN1,Protein stability and degradation,cnaPRAD7,3,3,1.0397337817221384,-1.4921124506912864,-.78726831317190404,,,.27917985705956178,-.70484413751938235,.78486715704441667,.55054773860790129,.33098631694841013,,.93669918499970262,0,PRAD,GDSC2
BDP-00009066,1866,MRCKB_HUMAN,Cytoskeleton,cnaPRAD7,3,3,1.1784531598512669,2.0877990251419387,3.6758957508544055,,,.27603658203569992,-1.5880967257124667,.39424276884332676,1.8645870200297712,.37593277901913441,,.18757076283850588,0,PRAD,GDSC2
Buparlisib,1873,PI3Kalpha, PI3Kdelta, PI3Kbeta, PI3Kgamma,PI3K/MTOR signaling,cnaPRAD7,3,3,.1011300243694956,1.2172413703057241,1.1249311723745923,,,.90752460031358462,.092310197931131821,.97760202943401586,.84300381914064826,.8390283569241469,,.78541286221643447,0,PRAD,GDSC2
Ulixertinib,1908,ERK1, ERK2,ERK MAPK signaling,cnaPRAD7,3,3,.58151936040120711,4.1656336608236533,3.5063740259020215,,,.51595901807247391,.65925963492163175,1.0825355967839017,1.1826237521934166,.35234000529256443,,.45026542444885898,0,PRAD,GDSC2
Venetoclax,1909,BCL2,Apoptosis regulation,cnaPRAD7,3,3,1.2527850932434457,2.6920272750503926,1.8913311748657857,,,.21459461015731571,.80069610018460691,.7734409956013828,.46772920813823426,.27073118936562074,,.055547445271168665,0,PRAD,GDSC2
ABT737,1910,BCL2, BCL-XL,  BCL-W, BCL-B, BFL1,Apoptosis regulation,cnaPRAD7,3,3,4.422227446957459,3.7856666678063906,1.8473187781913094,,,.0088925818587112793,1.9383478896150812,.33327176830190042,.52266398892843258,.017749468008241096,,.32575207816330798,0,PRAD,GDSC2
Afuresertib,1912,AKT1, AKT2, AKT3,PI3K/MTOR signaling,cnaPRAD7,3,3,1.1563660933551518,3.3067392746801993,.3755353365028456,,,.25285244200250934,2.9312039381773536,1.6171750445522119,3.1993093796127869,.074770617223285235,,.23424614295675955,0,PRAD,GDSC2
AGI-5198,1913,IDH1 (R132H),Metabolism,cnaPRAD7,3,3,2.6267889586120874,5.1807335281683331,3.8265918054477113,,,.043995251500987508,1.3541417227206218,.62939682338353953,.36792019526090902,.082172609345164876,,.22868675456750934,0,PRAD,GDSC2
AZD3759,1915,EGFR,EGFR signaling,cnaPRAD7,3,3,.11479543631320395,3.108842023449105,3.059063806814148,,,.89786463928843585,.049778216634956962,.24668670669557197,.56143355656144434,.73826122313902309,,.56726943459129242,0,PRAD,GDSC2
AZD5363,1916,AKT1, AKT2, AKT3, ROCK2,Other, kinases,cnaPRAD7,3,3,.82136113467495708,3.0939984592803795,1.1905179545645208,,,.41517286179697616,1.9034805047158587,.56073960537338485,3.2290731761408353,.18704839567516499,,.3236443274244819,0,PRAD,GDSC2
AZD6738,1917,ATR,Genome integrity,cnaPRAD7,3,3,.35402564290302929,2.2700452269558116,2.8286764447635293,,,.68958715465938902,-.55863121780771774,1.2679442341833453,1.8363296583948776,.80480245573801579,,.73161053335316906,0,PRAD,GDSC2
AZD8186,1918,PI3Kalpha, PI3Kbeta,PI3K/MTOR signaling,cnaPRAD7,3,3,1.2530703753584786,3.9533300301855099,1.1904294453376685,,,.26061360451120963,2.7629005848478414,.40499492783897223,3.0917935486354593,.10315233560686836,,.39972721965355329,0,PRAD,GDSC2
Osimertinib,1919,EGFR,EGFR signaling,cnaPRAD7,3,3,.29846272550976094,2.1874213235392168,1.8889315610109694,,,.73811439326403017,.29848976252824744,.68395832475444396,1.2379674376833658,.64851335033718149,,.69786789864780463,0,PRAD,GDSC2
Cediranib,1922,VEGFR, FLT1, FLT2, FLT3, FLT4, KIT, PDGFRB,RTK signaling,cnaPRAD7,3,3,.45729464400034581,2.6423703027705447,3.2639936523886846,,,.60907278410716792,-.62162334961813981,1.5889721195073607,1.0820494284715587,.67647138679058438,,.88841951333909963,0,PRAD,GDSC2
Ipatasertib,1924,AKT1, AKT, AKT3,PI3K/MTOR signaling,cnaPRAD7,3,3,.84166257764143027,3.7234892716129067,1.5896067979590915,,,.4070183819029094,2.1338824736538151,.52796268582704475,3.5463971043269593,.22517983319274182,,.4330708399905786,0,PRAD,GDSC2
GDC0810,1925,ESR1, ESR2,Hormone-related,cnaPRAD7,3,3,.84094769272903902,5.5563056951195691,4.3798118753978548,,,.40164506965147778,1.1764938197217143,.46111411622227794,1.9240137710441205,.26037075269859172,,.52630472982424292,0,PRAD,GDSC2
GNE-317,1926,PI3Kalpha,PI3K/MTOR signaling,cnaPRAD7,3,3,.53094463513854107,1.2684181877442462,.39458798260348038,,,.55098093052621777,.87383020514076581,1.636304509501856,1.6552467296856008,.47681293485083248,,.67218505557266706,0,PRAD,GDSC2
GSK2578215A,1927,LRRK2,Other, kinases,cnaPRAD7,3,3,.14227812310324681,5.2411044642154936,5.0627874728729587,,,.87319770375726513,.17831699134253487,.76805395920864428,1.5973755166933636,.80244505529238885,,.77752026159082976,0,PRAD,GDSC2
I-BRD9,1928,BRD9,Chromatin other,cnaPRAD7,3,3,.88945150612999435,5.3105480904581084,4.3255520214012817,,,.38797075514000123,.98499606905682668,.15113339510879625,1.5588185355122437,.38183788581336414,,.99585009594307805,0,PRAD,GDSC2
Telomerase Inhibitor IX,1930,Telomerase,Genome integrity,cnaPRAD7,3,3,.37249117156156403,.58184332528290439,.41756241000787675,,,.68224219918044859,.16428091527502764,.24618536707782826,.57307334340580873,.15253617185821627,,.065780783757592706,0,PRAD,GDSC2
MIRA-1,1931,TP53,p53 pathway,cnaPRAD7,3,3,.77544966005123306,5.7386009450373736,6.1261576753966951,,,.39727724051890612,-.38755673035932148,.45861869416192569,.53780612985554876,.40720910531770105,,.88173091701124628,0,PRAD,GDSC2
NVP-ADW742,1932,IGF1R,IGF1R signaling,cnaPRAD7,3,3,.39243979054117073,3.6357145138296247,3.0566224611974491,,,.6598129294388666,.57909205263217567,1.1346405702641296,1.7514280689761714,.6895044942250349,,.99455843903111074,0,PRAD,GDSC2
P22077,1933,USP7, USP47,Protein stability and degradation,cnaPRAD7,3,3,.67612716339078849,5.3756597698719935,4.1951567241581111,,,.46900096449399747,1.1805030457138823,1.1168716068192617,2.2021523707507038,.44217432438837645,,.81972543704690215,0,PRAD,GDSC2
Savolitinib,1936,MET,RTK signaling,cnaPRAD7,3,3,.30912748599682555,2.8292473100125957,3.0891646219525111,,,.73251681527783985,-.25991731193991541,1.0909604620291877,.47299718572306382,.41433300865229128,,.27220652311529542,0,PRAD,GDSC2
UMI-77,1939,MCL1,Apoptosis regulation,cnaPRAD7,3,3,1.5555083982962985,3.455318403209191,1.8558372227463031,,,.17726715174521573,1.5994811804628879,1.3923297183797967,.41963380797567962,.18001324266194715,,.87662118869829309,0,PRAD,GDSC2
WIKI4,1940,TNKS1, TNKS2,WNT signaling,cnaPRAD7,3,3,2.4740237502041182,4.6802697558745265,2.8756934151306233,,,.091030713233605107,1.8045763407439033,.1149916445048072,1.0251113392187337,.01950340510210927,,.58887976723554636,0,PRAD,GDSC2
Sepantronium bromide,1941,BIRC5,Apoptosis regulation,cnaPRAD7,3,3,.42845268021909522,-4.1618728855566758,-4.70974677445348,,,.63110568123830213,.54787388889680422,1.013082877134696,1.4979810126890962,.87010420690597112,,.37426772067126096,0,PRAD,GDSC2
MIM1,1996,MCL1,Apoptosis regulation,cnaPRAD7,3,3,.066110208046840077,4.1935764448106516,4.2440601047031192,,,.93951749647378002,-.050483659892467614,.67927678826935889,.83954808200096265,.55939270991200229,,.11509477238965904,0,PRAD,GDSC2
WEHI-539,1997,BCL-XL,Apoptosis regulation,cnaPRAD7,3,3,.014672755364326837,4.190791485914791,4.1984728280603951,,,.98717559905932195,-.0076813421456041198,.15233594424548855,.72451386450186284,.77532164761585598,,.41796471890170317,0,PRAD,GDSC2
BPD-00008900,1998,,Other,cnaPRAD7,3,3,.87995977836496797,4.4650170710856791,5.3625310624278422,,,.36245262549140211,-.89751399134216303,.63325852225416701,1.2959842144258402,.49562814697489599,,.037103427696559707,0,PRAD,GDSC2
Foretinib,2040,MET, KDR, TIE2, VEGFR3/FLT4, RON, PDGFR, FGFR1, EGFR,RTK signaling,cnaPRAD7,3,3,.59755011344930886,1.5395906882428319,2.498753653004588,,,.50533345849967148,-.95916296476175611,1.6948413425836173,1.5101602208541627,.49744210932427835,,.84614317098651981,0,PRAD,GDSC2
BIBR-1532,2043,TERT,Genome integrity,cnaPRAD7,3,3,.53822404998525386,5.0406964877439364,4.4290633527646186,,,.54672029468147698,.61163313497931782,1.0380943116181423,1.226837655842925,.58591542185078715,,.99760527333918547,0,PRAD,GDSC2
Pyridostatin,2044,G-quadruplex stabiliser,DNA replication,cnaPRAD7,3,3,.4829261082794401,3.2787454746215601,4.034300910509752,,,.58792548379959153,-.75555543588819196,1.3527204517514246,1.7509126670230131,.7051759288432502,,.73563994077615513,0,PRAD,GDSC2
AMG-319,2045,PI3K (beta sparing),PI3K/MTOR signaling,cnaPRAD7,3,3,1.0897798857776002,5.5734519575692021,3.8343321568933817,,,.28967683182930493,1.7391198006758204,.77261596841267011,2.1204969238032199,.24527989810273759,,.78931145999097463,0,PRAD,GDSC2
MK-8776,2046,CHEK1, CHEK2, CDK2,Cell cycle,cnaPRAD7,3,3,.005381752436157441,3.9579986198090022,3.9634521379562107,,,.99508150736285605,-.0054535181472084027,.85460581486983811,1.15036714900532,.95472687621431152,,.86030333615708154,95.472687621431149,PRAD,GDSC2
Ulixertinib,2047,ERK1, ERK2,ERK MAPK signaling,cnaPRAD7,3,3,.12125136930283667,2.9092928174418335,2.7444286993095894,,,.89437238494140769,.16486411813224411,.43659873931157112,1.8726687712630572,.83797706406350136,,.8267001871546622,0,PRAD,GDSC2
Vinorelbine,2048,Microtubule destabiliser,Mitosis,cnaPRAD7,3,3,1.0761505144389749,-3.9960476418297084,-2.0902575717222622,,,.30055223613438581,-1.9057900701074462,.7288218795393242,2.3960850337778168,.39994270395997628,,.51790465486850268,0,PRAD,GDSC2
VX-11e,2096,ERK2,ERK MAPK signaling,cnaPRAD7,3,3,1.197168986303371,3.3557287898001662,4.4556878819231747,,,.27725487137670024,-1.0999590921230085,.14703390633372487,1.2910339301565936,.36982953260485363,,.21524228059797232,0,PRAD,GDSC2
Uprosertib,2106,AKT1, AKT2, AKT3,PI3K/MTOR signaling,cnaPRAD7,3,3,.63734050543646437,3.3986873156829946,1.1708952263507622,,,.49925229387281234,2.2277920893322323,1.8406989061637751,4.5878288720774174,.32736840092294239,,.46035798089240154,0,PRAD,GDSC2
LJI308,2107,RSK2, RSK1, RSK3,PI3K/MTOR signaling,cnaPRAD7,3,3,.59000878370107124,5.1963626088526675,5.6093892333818651,,,.52280212499065826,-.41302662452919758,.44675149798368158,.88346492514227393,.68125622628440707,,.55322707941347471,0,PRAD,GDSC2
AZ6102,2109,TNKS1, TNKS2,WNT signaling,cnaPRAD7,3,3,.43256227405861047,3.031758232152125,3.8975102812394149,,,.63336487847753575,-.86575204908728987,1.2804557230977811,2.5242905207950459,.81349438810690133,,.5188164519333518,0,PRAD,GDSC2
GSK591,2110,PMRT5,Chromatin histone methylation,cnaPRAD7,3,3,.080029035399809018,4.6838435505301677,4.7560603255653344,,,.92779277354987266,-.072216775035166769,1.1095317157604565,.6304970670788359,.74366385056319984,,.51662169130963653,0,PRAD,GDSC2
VE821,2111,ATR,Genome integrity,cnaPRAD7,3,3,.42210630288123924,5.0725833146855654,4.4417670185065914,,,.63489287793447868,.63081629617897406,1.2424371665249254,1.7097089992768575,.65922575792984672,,.97933719919829998,0,PRAD,GDSC2
AT13148,2170,AKT1,PI3K/MTOR signaling,cnaPRAD7,3,3,.39231976909055893,2.9032458544196036,3.7220013584596345,,,.66642958132447117,-.81875550404003095,1.1944815733649203,2.6988913321494632,.8898305406059468,,.40412939461713221,0,PRAD,GDSC2