#ID	name	JZ2a	JZ2b	JZ2c	JZ2d	JZ2e	JZ2f	KLD2a	KLD2b	KLD2c	KLD2d	KLD2e	KLD2f	JZ_Mean	KLD_Mean	Fold_change	log2FC	P-value of t test	VIP	regulated	P-value of Mann-Whitney-Wilcoxon test	HMDB_taxonomy	KEGG_annotation	KEGG_pathway_annotation	HMDB_ID	pubchem_id	CAS	HMDB_super_class	HMDB_sub_class
pos_3	Guanine	1.23E-05	8.23E-06	3.78E-06	4.93E-06	1.05E-05	1.31E-05	0	1.05E-06	0	8.19E-07	0	0	8.81E-06	3.12E-07	0.04	-4.819251195	0.002758012	1.289146138	down	0.004336913	Imidazopyrimidines	C00242	Purine metabolism(ko00230);;Metabolic pathways(ko01100)	HMDB0000132	764	73-40-5	Organoheterocyclic compounds	Purines and purine derivatives
pos_4	12-Hydroxydodecanoic acid	4.62E-05	5.08E-05	3.92E-05	5.69E-05	4.19E-05	5.66E-05	9.79E-05	0.000104249	7.43E-05	9.21E-05	6.46E-05	8.95E-05	4.86E-05	8.71E-05	1.79	0.841913699	0.000641716	1.322069256	up	0.002164502	Hydroxy acids and derivatives	--	--	HMDB0002059	79034	505-95-3	Organic acids and derivatives	Medium-chain hydroxy acids and derivatives
pos_6	Decanoic acid	5.30E-06	5.14E-06	5.47E-06	6.59E-06	4.41E-06	7.99E-06	2.14E-05	1.16E-05	1.02E-05	1.30E-05	1.24E-05	1.26E-05	5.82E-06	1.35E-05	2.33	1.217805961	0.004005238	1.22809941	up	0.002164502	Fatty Acyls	C01571	Fatty acid biosynthesis(ko00061);;Metabolic pathways(ko01100)	HMDB0000513	2969	59906-14-8	Lipids and lipid-like molecules	Fatty acids and conjugates
pos_7	"(6,9,12)-Linolenic acid"	2.29E-05	7.77E-06	6.40E-06	5.58E-06	2.09E-05	1.52E-05	5.67E-07	3.97E-06	8.93E-06	0	3.48E-06	1.55E-06	1.31E-05	3.08E-06	0.23	-2.089765089	0.02192257	1.037123357	down	0.015151515	--	--	--	--	--	--	--	--
pos_18	MG(18:1(9Z)/0:0/0:0)[rac]	6.69E-06	6.48E-06	2.74E-06	5.80E-06	8.20E-06	5.07E-06	0.000102114	0.000119483	9.56E-05	5.96E-05	8.79E-05	9.31E-05	5.83E-06	9.30E-05	15.95	3.995535134	0.000105757	1.43120336	up	0.002164502	--	--	--	--	--	--	--	--
pos_20	Eschscholtzxanthin	1.95E-05	5.68E-05	3.55E-05	9.01E-05	6.96E-05	0.000116262	0.000202773	0.000225275	0.000161404	0.000193112	0.000159481	0.000185269	6.46E-05	0.000187886	2.91	1.539482421	6.68E-05	1.372861098	up	0.002164502	--	--	--	--	--	--	--	--
pos_21	"N,N-dimethyl-Safingol"	0.00238136	0.00191099	0.003683379	0.002476456	0.003327023	0.00292947	0.004556538	0.005186624	0.006111301	0.006078649	0.004955467	0.007065682	0.00278478	0.005659043	2.03	1.022994953	0.000158105	1.315910256	up	0.002164502	--	--	--	--	--	--	--	--
pos_25	Elenaic acid	0.002218223	0.001396668	0.003354817	0.002404745	0.003871964	0.002480866	0.000592967	0.000679183	0.000961293	0.001343253	0.00084987	0.000454494	0.002621214	0.00081351	0.31	-1.688003398	0.002769382	1.217853939	down	0.002164502	--	--	--	--	--	--	--	--
pos_31	"METHYLORSELLINIC ACID, ETHYL ESTER"	0.000175272	7.38E-05	0.000131835	7.95E-05	0.000152541	0.000171739	5.36E-05	4.57E-05	4.13E-05	5.57E-05	2.80E-05	4.01E-05	0.000130778	4.41E-05	0.34	-1.569899402	0.004447422	1.220695612	down	0.002164502	--	--	--	--	--	--	--	--
pos_34	"2,6-nonadienal"	9.85E-06	7.19E-06	7.98E-06	9.38E-06	9.27E-06	1.20E-05	1.45E-05	1.26E-05	1.56E-05	1.34E-05	1.18E-05	1.85E-05	9.28E-06	1.44E-05	1.55	0.633672586	0.002078933	1.19610844	up	0.004329004	Organooxygen compounds	--	--	HMDB0033857	643731	557-48-2	Organic oxygen compounds	Carbonyl compounds
pos_35	"trans,trans-hepta-2,4,6-trienoic acid"	0.0001592	4.92E-05	0.000152392	5.12E-05	0.00014719	7.41E-05	0.00024461	0.000565362	0.00038482	0.000196989	0.000279782	0.000177804	0.000105542	0.000308228	2.92	1.546182362	0.017371067	1.079838967	up	0.002164502	--	--	--	--	--	--	--	--
pos_38	CANTHARIDIN	0.005772113	0.004356834	0.003779628	0.004083957	0.005845756	0.005224025	0.007156179	0.007354522	0.005898015	0.007836185	0.006500471	0.008885575	0.004843719	0.007271825	1.5	0.586202283	0.001547416	1.172997537	up	0.002164502	--	--	--	--	--	--	--	--
pos_40	"3,4-Methylenedioxybenzoic acid"	4.97E-05	2.14E-05	0.000129832	2.11E-05	7.72E-05	4.82E-05	2.93E-06	1.00E-05	1.02E-05	2.97E-06	1.29E-06	6.60E-06	5.79E-05	5.67E-06	0.1	-3.353068507	0.025956699	1.012873409	down	0.002164502	--	--	--	--	--	--	--	--
pos_43	4-Ethyl-2-methoxyphenol	9.00E-05	3.39E-05	2.22E-05	3.13E-05	4.14E-05	4.23E-05	0.000179537	0.000275377	0.000134315	0.000181419	0.000210854	0.00023965	4.35E-05	0.000203526	4.68	2.226018408	0.000169921	1.340881458	up	0.002164502	--	--	--	--	--	--	--	--
pos_45	"3',4'-(Methylenedioxy)acetophenone"	0.03009371	0.026760805	0.061163475	0.038125441	0.046087494	0.040152714	0.013360409	0.015639765	0.021246806	0.016756804	0.012752548	0.010931485	0.040397273	0.015114636	0.37	-1.418311663	0.003141278	1.200032302	down	0.002164502	--	--	--	--	--	--	--	--
pos_47	Cinnamaldehyde	0.000468867	0.000445253	0.000413031	0.000432863	0.000559097	0.000628997	0.000326495	0.000366983	0.000320463	0.000336079	0.00042171	0.000392686	0.000491351	0.000360736	0.73	-0.44581174	0.010802483	1.095873763	down	0.004329004	Cinnamaldehydes	C00903	Phenylpropanoid biosynthesis(ko00940);;Biosynthesis of secondary metabolites(ko01110);;Metabolic pathways(ko01100)	HMDB0003441	637511	104-55-2	Phenylpropanoids and polyketides	--
pos_49	Phosphocholine	0.002023571	0.001716607	0.00171327	0.001304216	0.001099912	0.000835305	0.000958937	0.000714653	0.000636541	0.000523085	0.000442595	0.000502083	0.001448813	0.000629649	0.43	-1.202251691	0.004665666	1.178229962	down	0.004329004	Organonitrogen compounds	C00588	Glycerophospholipid metabolism(ko00564);;Metabolic pathways(ko01100)	HMDB0001565	1014	3616/4/4	Organic nitrogen compounds	Quaternary ammonium salts
pos_54	3-Methoxy-4-hydroxyphenylethylene glycol	0.002487916	0.000810266	0.002876714	0.000912002	0.00248266	0.000834529	0.005163746	0.012521387	0.008881578	0.004636739	0.006094857	0.002460932	0.001734015	0.00662654	3.82	1.934139709	0.018768376	1.086868334	up	0.015151515	--	--	--	--	--	--	--	--
pos_55	Quinic acid	0.002227183	0.002181559	0.001328304	0.002099308	0.002491796	0.002665868	0.003307985	0.00336502	0.002667377	0.002757708	0.003132771	0.003488422	0.002165669	0.003119881	1.44	0.526677718	0.002629136	1.162994532	up	0.002164502	Organooxygen compounds	C00296	"Metabolic pathways(ko01100);;Phenylalanine, tyrosine and tryptophan biosynthesis(ko00400)"	HMDB0003072	6508	77-95-2	Organic oxygen compounds	Alcohols and polyols
pos_56	Sinensetin	0.001918053	0.001829528	0.001618003	0.002087358	0.001778039	0.002163952	0.003142273	0.002627193	0.002599457	0.003365412	0.002270425	0.003352326	0.001899155	0.002892847	1.52	0.607132377	0.001880095	1.24536937	up	0.002164502	--	--	--	--	--	--	--	--
pos_57	Oleoyl Ethanolamide	0.000113132	0.000190041	0.000116677	0.000245245	0.000154611	0.000178475	0.000446425	0.000365157	0.000463981	0.000499406	0.000478578	0.000669873	0.000166363	0.000487237	2.93	1.55028492	0.000173873	1.331983993	up	0.002164502	Organonitrogen compounds	--	--	HMDB0002088	5283454	111-58-0	Organic nitrogen compounds	Amines
pos_59	"4-Ethyl-1,2-dimethoxybenzene"	1.96E-05	5.85E-06	2.48E-05	1.24E-05	2.91E-05	3.01E-05	0	0	9.05E-07	0	0	0	2.03E-05	1.51E-07	0.01	-7.073897627	0.003676174	1.242603522	down	0.003664548	--	--	--	--	--	--	--	--
pos_60	Crotamiton	0.000102303	0.000100166	0.000110625	0.000123343	0.000124647	0.000127638	0.00018832	0.000171575	0.000167716	0.000162118	0.00015026	0.00019176	0.000114787	0.000171958	1.5	0.583098635	4.92E-05	1.375297269	up	0.002164502	--	--	--	--	--	--	--	--
pos_61	"2,5-Dimethylbenzaldehyde"	0.000326805	0.000367133	0.00029598	0.000395096	0.000427489	0.000396388	0.000154862	0.000174682	0.000132595	0.0001673	0.000166832	0.000189711	0.000368149	0.00016433	0.45	-1.163689173	4.70E-05	1.395910537	down	0.002164502	Benzene and substituted derivatives	--	--	HMDB0032014	10236014	34341-29-2	Benzenoids	Benzoyl derivatives
pos_62	Maltol propionate	0.002959679	0.00281482	0.006889189	0.004803143	0.004482484	0.004517629	0.008173046	0.012003695	0.008031201	0.007523144	0.006929702	0.003586962	0.004411157	0.007707958	1.75	0.805191544	0.031262894	1.003385752	up	0.025974026	--	--	--	--	--	--	--	--
pos_63	Furapiole	0.000331851	0.000239641	0.000644106	0.000403759	0.000430603	0.000485792	0.000123262	0.000186495	0.000182237	0.000175223	0.000146403	0.000128988	0.000422625	0.000157101	0.37	-1.427682434	0.004710486	1.182747071	down	0.002164502	--	--	--	--	--	--	--	--
pos_64	Benzyl alcohol	0.000186441	0.000209738	0.00010007	0.00017465	0.000210605	0.000201111	3.91E-05	5.76E-05	6.75E-05	8.18E-05	6.39E-05	9.49E-05	0.000180436	6.75E-05	0.37	-1.419064179	0.000521517	1.328409178	down	0.002164502	--	C00556	Metabolic pathways(ko01100)	--	--	--	--	--
pos_65	Glucocerebrosides	0.009682621	0.00841446	0.007978176	0.011949894	0.010421418	0.014831975	0.016441938	0.013004327	0.018349553	0.019827494	0.013868277	0.025557962	0.010546424	0.017841592	1.69	0.758490431	0.009534288	1.07885655	up	0.008658009	--	--	--	--	--	--	--	--
pos_67	Eicosanoyl-EA	0.000894608	0.000742271	0.001086918	0.000861487	0.001046214	0.001047063	0.001594747	0.001434182	0.001594695	0.001609771	0.00123213	0.001836917	0.000946427	0.001550407	1.64	0.71208395	0.000207511	1.326037141	up	0.002164502	--	--	--	--	--	--	--	--
pos_70	HERNIARIN	0.000240323	0.000182358	0.000262309	0.000233343	0.000307873	0.000299593	0.00018014	0.000182321	0.000179511	0.000214632	0.000196508	0.000185569	0.0002543	0.00018978	0.75	-0.422201971	0.017783966	1.052166667	down	0.015151515	--	--	--	--	--	--	--	--
pos_71	alpha-Methylstyrene	0.000227513	0.000279723	0.000224962	0.000307294	0.000225106	0.000272609	0.000399054	0.000377133	0.000295239	0.000405738	0.000249144	0.000370611	0.000256201	0.000349486	1.36	0.447958869	0.013606184	1.084984119	up	0.025974026	--	--	--	--	--	--	--	--
pos_72	"4-Methyl-3Z,5-hexadienoic acid"	5.64E-06	6.57E-06	9.65E-07	1.95E-06	3.82E-06	4.37E-06	0	0	0	9.06E-07	0	0	3.89E-06	1.51E-07	0.04	-4.68569071	0.007320551	1.220241755	down	0.003664548	--	--	--	--	--	--	--	--
pos_74	2-Isopropylfuran	8.88E-05	4.13E-05	2.24E-05	2.42E-05	4.57E-05	4.19E-05	0.000166702	0.000218929	0.000113592	0.000154222	0.000179383	0.000230856	4.40E-05	0.000177281	4.02	2.008951399	0.000185058	1.318041218	up	0.002164502	--	--	--	--	--	--	--	--
pos_75	Styrene	0.000112123	4.26E-05	0.000120279	3.87E-05	0.000103448	0.00011396	2.09E-05	2.28E-05	1.93E-05	2.10E-05	1.66E-05	1.95E-05	8.85E-05	2.00E-05	0.23	-2.144415387	0.006489753	1.202565861	down	0.002164502	--	C07083	Metabolic pathways(ko01100)	--	--	--	--	--
pos_76	"1-Methyl-1,3-cyclohexadiene"	8.86E-05	6.60E-05	6.45E-05	7.63E-05	0.000107856	9.20E-05	0.000122193	0.000129566	0.000103726	0.000155832	0.000115729	0.000139667	8.26E-05	0.000127786	1.55	0.630259734	0.001249684	1.190140387	up	0.004329004	--	--	--	--	--	--	--	--
pos_77	CITROPTEN	0.001222581	0.001181596	0.002094423	0.001594081	0.001743989	0.001799309	0.000776683	0.001008629	0.000992014	0.00075558	0.000696633	0.000628841	0.001605996	0.00080973	0.5	-0.987955838	0.001542181	1.204655028	down	0.002164502	Coumarins and derivatives	--	--	HMDB0032952	2775	487-06-9	Phenylpropanoids and polyketides	--
pos_81	Eschscholtzxanthone	3.00E-05	6.95E-05	2.15E-05	9.57E-05	5.29E-05	0.000104315	0.00037236	0.000374477	0.000242538	0.000228563	0.000207303	0.000317358	6.23E-05	0.000290433	4.66	2.220772803	0.000242414	1.373932091	up	0.002164502	--	--	--	--	--	--	--	--
pos_82	Gingerglycolipid C	4.87E-05	9.38E-05	5.04E-05	7.39E-05	6.18E-05	4.77E-05	0.00128449	0.001201016	0.001050944	0.000817849	0.000805651	0.001290521	6.27E-05	0.001075078	17.15	4.099918455	9.29E-05	1.436379532	up	0.002164502	Glycerolipids	--	--	HMDB0041095	131753024	35949-86-1	Lipids and lipid-like molecules	Glycosylglycerols
pos_86	1-Ipomeanol	0.001309691	0.000824924	0.000789123	0.000717788	0.000929242	0.001051931	0.001820996	0.001770409	0.001387601	0.001800626	0.001315953	0.002536124	0.000937117	0.001771952	1.89	0.919038795	0.003562523	1.173102341	up	0.002164502	Heteroaromatic compounds	--	--	HMDB0030473	161819	34435-70-6	Organoheterocyclic compounds	--
pos_87	alpha-Vetivone	0.00100726	0.000919733	0.000979549	0.000953838	0.001129594	0.001081121	0.001908817	0.001707365	0.001668271	0.001504447	0.001502089	0.001913126	0.001011849	0.001700686	1.68	0.749122362	7.40E-05	1.39784832	up	0.002164502	--	--	--	--	--	--	--	--
pos_88	dehydrocholic acid	2.74E-05	6.79E-06	1.40E-05	2.90E-05	5.12E-05	4.41E-05	8.56E-05	6.89E-05	3.59E-05	5.73E-05	4.08E-05	7.81E-05	2.87E-05	6.11E-05	2.13	1.088055049	0.013443423	1.048282267	up	0.025974026	--	--	--	--	--	--	--	--
pos_89	Damascenine	0.004858857	0.005420307	0.003172912	0.003810714	0.004172532	0.005053031	0.007891554	0.00899592	0.009349092	0.011146129	0.010003776	0.008610563	0.004414726	0.009332839	2.11	1.079992239	1.14E-05	1.353283923	up	0.002164502	--	--	--	--	--	--	--	--
pos_90	Gly Glu Gly Phe	0.005228501	0.004370339	0.003933607	0.0043524	0.005161528	0.005143979	0.00649482	0.006740053	0.005361995	0.009149475	0.005792966	0.006992748	0.004698392	0.006755343	1.44	0.523861794	0.010473235	1.080160001	up	0.002164502	--	--	--	--	--	--	--	--
pos_91	4-Hydroxy-3-methoxyphenethyl alcohol	0.009047607	0.006442332	0.00599981	0.00650068	0.00953762	0.008488159	0.011452851	0.011710062	0.00916578	0.012828161	0.010000872	0.01334913	0.007669368	0.011417809	1.49	0.574106229	0.002024376	1.157954632	up	0.004329004	Phenols	--	--	HMDB0038925	16928	2380-78-1	Benzenoids	Methoxyphenols
pos_92	"1,2-Dihydro-1,1,6-trimethylnaphthalene"	2.82E-06	3.00E-06	3.10E-06	2.70E-06	4.19E-06	2.16E-06	3.43E-06	5.44E-06	6.04E-06	5.30E-06	6.42E-06	6.13E-06	3.00E-06	5.46E-06	1.82	0.865777605	0.001300868	1.194951732	up	0.004329004	--	--	--	--	--	--	--	--
pos_94	Anisole	0.000167412	0.00010715	0.000115779	0.000100959	0.000137862	0.000143043	0.000250422	0.000246682	0.000212125	0.000273096	0.000213476	0.000312104	0.000128701	0.000251318	1.95	0.965492361	0.000114702	1.319325853	up	0.002164502	--	--	--	--	--	--	--	--
pos_98	"(2E,6Z)-nona-2,6-dienal"	7.33E-06	6.92E-06	6.98E-06	8.03E-06	7.37E-06	1.07E-05	1.84E-05	1.30E-05	1.58E-05	1.24E-05	1.43E-05	1.39E-05	7.88E-06	1.46E-05	1.86	0.891923524	0.000166604	1.336172467	up	0.002164502	Organooxygen compounds	--	--	HMDB0033857	643731	557-48-2	Organic oxygen compounds	Carbonyl compounds
pos_100	"3,6,8-dodecatrien-1-ol"	0.000166501	0.000170984	0.000177072	0.000195946	0.000205646	0.000303944	0.000372606	0.000327405	0.000628029	0.000403673	0.00038786	0.000594788	0.000203349	0.000452394	2.22	1.153622487	0.003309096	1.202546287	up	0.002164502	--	--	--	--	--	--	--	--
pos_101	"4E,8-Nonadienal"	4.25E-06	3.71E-06	3.96E-06	5.08E-06	4.30E-06	4.84E-06	6.41E-06	6.62E-06	8.24E-06	6.05E-06	6.09E-06	7.73E-06	4.36E-06	6.86E-06	1.57	0.65453271	0.000399941	1.313939049	up	0.002164502	--	--	--	--	--	--	--	--
pos_102	p-Anisaldehyde	0.009795614	0.007976037	0.009055067	0.009314536	0.013940385	0.010171003	0.003221078	0.005446831	0.005416354	0.006140042	0.00534593	0.00399876	0.010042107	0.004928166	0.49	-1.026939276	0.000770205	1.278871155	down	0.002164502	Benzene and substituted derivatives	--	--	HMDB0029686	31244	123-11-5	Benzenoids	Benzoyl derivatives
pos_103	Xanthorrhizol	0.00072185	0.000670914	0.000722735	0.000726828	0.000774522	0.000779211	0.001344707	0.001198275	0.001185505	0.001072189	0.001045308	0.001276702	0.000732677	0.001187114	1.62	0.696210496	8.12E-05	1.415453341	up	0.002164502	--	--	--	--	--	--	--	--
pos_105	Methyl sorbate	1.33E-06	6.95E-07	7.77E-07	1.07E-06	1.79E-06	7.22E-07	3.30E-06	4.20E-06	1.32E-06	4.27E-06	3.75E-06	3.33E-06	1.06E-06	3.36E-06	3.16	1.660006989	0.002300965	1.221205608	up	0.008658009	--	--	--	--	--	--	--	--
pos_106	"Ethyl 3,4,5-trimethoxybenzoate"	0.000130133	8.82E-05	0.000321479	0.000192456	0.000187133	0.000238362	2.57E-05	2.54E-05	5.26E-05	2.82E-05	3.17E-05	2.61E-05	0.000192965	3.16E-05	0.16	-2.609917165	0.004535084	1.196586127	down	0.002164502	--	--	--	--	--	--	--	--
pos_109	"2-methyl-1,3-Cyclohexanedione"	4.86E-06	1.40E-07	7.49E-07	0	0	1.50E-07	6.20E-06	1.24E-05	2.32E-06	5.36E-06	6.95E-06	7.27E-06	9.84E-07	6.75E-06	6.87	2.779348501	0.005924571	1.121725949	up	0.008127043	--	--	--	--	--	--	--	--
pos_112	4-Vinylcyclohexene	8.15E-05	9.63E-05	7.12E-05	9.94E-05	0.00010426	9.17E-05	3.43E-05	4.11E-05	2.63E-05	2.86E-05	3.65E-05	3.90E-05	9.07E-05	3.43E-05	0.38	-1.403075149	1.74E-05	1.403874704	down	0.002164502	--	--	--	--	--	--	--	--
pos_113	Perillic acid	0.002020356	0.000933974	0.001659368	0.001023875	0.002102554	0.00185265	0.000230528	0.000253163	0.000305325	0.000331751	0.000277848	0.000350206	0.001598796	0.00029147	0.18	-2.455565198	0.001372619	1.327669788	down	0.002164502	Prenol lipids	C11924	Limonene and pinene degradation(ko00903)	HMDB0004586	1256	7694-45-3	Lipids and lipid-like molecules	Monoterpenoids
pos_114	Cer(d14:1(4E)/20:0(2OH))	0.000177182	0.000298354	0.000311525	0.000438123	0.000304385	0.000525766	0.001169476	0.001008731	0.001415267	0.00200551	0.001036571	0.002135101	0.000342556	0.001461776	4.27	2.093311532	0.002095547	1.2642493	up	0.002164502	--	--	--	--	--	--	--	--
pos_116	"1-(2-Methoxy-3,4-methylenedioxyphenyl)-1-propanone"	0.000122736	9.34E-05	0.000221123	0.000139954	0.000163669	0.000168314	6.16E-05	7.65E-05	9.85E-05	7.63E-05	6.42E-05	5.85E-05	0.000151527	7.26E-05	0.48	-1.061667514	0.005579471	1.140691327	down	0.004329004	--	--	--	--	--	--	--	--
pos_120	PC(0:0/18:1(6Z))	0.000487044	0.000301459	0.000461691	0.000266393	0.000590926	0.000571463	0.000748738	0.000706456	0.000765713	0.000509696	0.000601132	0.000808911	0.000446496	0.000690108	1.55	0.628174455	0.007314859	1.093240664	up	0.008658009	--	--	--	--	--	--	--	--
pos_123	R-(-)-Mandelic acid	0.000516249	0.0003015	0.000383605	0.000332123	0.000610352	0.00031173	0.000121346	0.000156279	0.000121889	0.000166502	0.000195746	0.000303044	0.00040926	0.000177468	0.43	-1.205461167	0.00452904	1.181776017	down	0.004329004	--	--	--	--	--	--	--	--
pos_125	"3,4-Dihydroxymandelaldehyde"	1.07E-05	8.31E-06	3.10E-05	1.56E-05	1.79E-05	1.67E-05	2.90E-06	4.92E-06	1.12E-06	2.12E-06	1.13E-06	6.35E-08	1.67E-05	2.04E-06	0.12	-3.033079492	0.005487334	1.161338929	down	0.002164502	Benzene and substituted derivatives	C05577	Tyrosine metabolism(ko00350);;Metabolic pathways(ko01100)	HMDB0006242	151725	13023-73-9	Benzenoids	Phenylacetaldehydes
pos_127	"cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol"	0.003161661	0.001165287	0.003665732	0.001729892	0.003587023	0.002255341	0.011014858	0.018661224	0.016715249	0.014187186	0.012795164	0.005874994	0.002594156	0.013208112	5.09	2.348087087	0.001788526	1.299046606	up	0.002164502	--	C11588	Phenylalanine metabolism(ko00360);;Metabolic pathways(ko01100)	--	--	--	--	--
pos_129	Monoanhydroescholtzxanthin	0.000497581	0.000552051	0.000326838	0.000473896	0.000532852	0.00063331	0.001079827	0.001440232	0.001047075	0.001054063	0.001334989	0.00141191	0.000502755	0.001228016	2.44	1.288403012	3.97E-05	1.372949583	up	0.002164502	--	--	--	--	--	--	--	--
pos_130	Anofinic acid	0.001117433	0.001076582	0.001156445	0.001279478	0.001314973	0.001476609	0.002213153	0.001839215	0.001968088	0.001943208	0.001743225	0.002296298	0.00123692	0.002000531	1.62	0.693630846	5.48E-05	1.366316545	up	0.002164502	--	--	--	--	--	--	--	--
pos_132	"cis-1,2-Dihydro-3-ethylcatechol"	0.000444828	0.0003206	0.000311208	0.00035182	0.000508297	0.000442546	0.000515044	0.000540611	0.000430538	0.000651645	0.000493078	0.000583197	0.00039655	0.000535685	1.35	0.433883562	0.011567689	1.008650523	up	0.025974026	--	C06727	Metabolic pathways(ko01100)	--	--	--	--	--
pos_133	Cumene	0.000179054	7.90E-05	0.000140232	0.000107594	0.000205776	0.000161222	8.57E-06	2.30E-05	9.60E-06	1.16E-05	1.04E-05	1.47E-05	0.000145475	1.30E-05	0.09	-3.486901435	0.000877948	1.34342128	down	0.002164502	Benzene and substituted derivatives	--	--	HMDB0034029	7406	98-82-8	Benzenoids	Cumenes
pos_134	UTILIN	0.002809042	0.002487805	0.002141629	0.002452577	0.002442844	0.002725656	0.00363259	0.003889351	0.003003037	0.005906723	0.003464747	0.004089827	0.002509926	0.003997713	1.59	0.67153014	0.01419127	1.076159163	up	0.002164502	--	--	--	--	--	--	--	--
pos_136	Tetrodotoxin	0.009532805	0.004454796	0.004045473	0.005552798	0.008624571	0.007515343	0.018245518	0.034848295	0.014795762	0.022259939	0.016686075	0.009128909	0.006620964	0.019327416	2.92	1.545535579	0.014988292	1.110020419	up	0.004329004	--	--	--	--	--	--	--	--
pos_138	"2-Methyl-1,3-cyclohexadiene"	2.67E-05	1.78E-05	1.59E-05	1.23E-05	2.13E-05	2.02E-05	5.04E-05	5.94E-05	2.99E-05	3.29E-05	3.37E-05	6.26E-05	1.90E-05	4.48E-05	2.35	1.235594437	0.00586193	1.186038911	up	0.002164502	--	--	--	--	--	--	--	--
pos_139	1-Piperidinecarboxaldehyde	1.66E-05	1.52E-05	1.74E-05	1.96E-05	1.93E-05	2.23E-05	3.16E-05	2.80E-05	3.34E-05	3.22E-05	2.66E-05	3.59E-05	1.84E-05	3.13E-05	1.7	0.765969216	3.87E-05	1.36808847	up	0.002164502	--	--	--	--	--	--	--	--
pos_140	Antibiotic X 14889D	0.0003436	0.000634438	0.00034814	0.000555394	0.000546383	0.000626527	0.001447949	0.001653202	0.001295029	0.001391006	0.001506867	0.001572097	0.00050908	0.001477692	2.9	1.537379888	1.46E-07	1.436438778	up	0.002164502	--	--	--	--	--	--	--	--
pos_141	Pro Asp Glu Asp	0.029395842	0.010943358	0.012179626	0.010218201	0.015830945	0.015262208	0.001583547	0.000980921	0.001857152	0.000887938	0.001486444	0.001818288	0.015638363	0.001435715	0.09	-3.445248268	0.004455384	1.268035063	down	0.002164502	--	--	--	--	--	--	--	--
pos_143	Phthalic acid Mono-2-ethylhexyl Ester	0.000769654	0.000721114	0.000746802	0.000860724	0.000896246	0.001069815	0.001669592	0.001392816	0.001608049	0.001557988	0.001401742	0.001940238	0.000844059	0.001595071	1.89	0.918204123	4.26E-05	1.368854312	up	0.002164502	Benzene and substituted derivatives	--	--	HMDB0013248	20393	4376-20-9	Benzenoids	Benzoic acids and derivatives
pos_144	"exo-5,6-Dimethylbicyclo[2.2.1]hept-5-en-2-ol"	0.000382316	0.000162262	0.000294094	0.000179214	0.000390702	0.000342166	4.27E-05	4.32E-05	4.91E-05	6.36E-05	5.06E-05	6.13E-05	0.000291792	5.17E-05	0.18	-2.495600625	0.001947396	1.308964496	down	0.002164502	--	--	--	--	--	--	--	--
pos_146	Nigrifactin	6.59E-06	5.75E-06	6.05E-06	7.48E-06	6.99E-06	7.71E-06	9.27E-06	1.27E-05	1.34E-05	8.68E-06	8.02E-06	1.24E-05	6.76E-06	1.08E-05	1.59	0.66900751	0.00741754	1.188301497	up	0.002164502	--	--	--	--	--	--	--	--
pos_148	"2,5-Furandicarboxylic acid"	6.99E-06	8.14E-06	9.04E-06	8.83E-06	1.14E-05	1.02E-05	1.46E-05	1.18E-05	1.26E-05	1.53E-05	1.17E-05	1.28E-05	9.09E-06	1.31E-05	1.44	0.530401068	0.000947292	1.233776318	up	0.002164502	Furans	--	--	HMDB0004812	76720	3238-40-2	Organoheterocyclic compounds	Furoic acid and derivatives
pos_152	"3Z,6E,8E-Dodecatrien-1-ol"	6.18E-05	6.45E-05	6.25E-05	8.05E-05	7.38E-05	0.000127731	0.000166736	0.000133073	0.000296756	0.000204869	0.000183286	0.000306115	7.85E-05	0.000215139	2.74	1.454675912	0.003937332	1.193112054	up	0.002164502	--	--	--	--	--	--	--	--
pos_154	Vanillylmandelic acid	0.000365213	0.000204074	0.000278505	0.000293455	0.000467052	0.000341743	0.000145436	0.000166674	0.000135915	0.000250824	0.000159349	0.000137177	0.000325007	0.000165896	0.51	-0.970193933	0.005339529	1.159800914	down	0.004329004	Phenols	C05584	Tyrosine metabolism(ko00350);;Metabolic pathways(ko01100)	HMDB0133489	1245	--	Benzenoids	Methoxyphenols
pos_155	"4,5-Dihydrovomifoliol"	7.21E-05	5.73E-05	8.90E-05	5.88E-05	0.000113873	0.000112521	0.000737388	0.000816808	0.000534704	0.000550268	0.00054676	0.000617426	8.39E-05	0.000633893	7.55	2.916773023	5.58E-05	1.439277626	up	0.002164502	--	--	--	--	--	--	--	--
pos_156	3E-Hexene-2-one	1.81E-05	1.46E-05	1.33E-05	1.49E-05	2.14E-05	1.92E-05	2.62E-05	2.50E-05	2.18E-05	3.21E-05	2.34E-05	2.92E-05	1.69E-05	2.63E-05	1.55	0.636526604	0.001000949	1.203798989	up	0.002164502	--	--	--	--	--	--	--	--
pos_157	3-Butylpyridine	8.30E-06	8.17E-06	8.14E-06	9.43E-06	1.00E-05	1.19E-05	1.51E-05	1.37E-05	1.44E-05	1.23E-05	1.11E-05	1.64E-05	9.32E-06	1.38E-05	1.49	0.571316487	0.001191297	1.247824516	up	0.004329004	--	--	--	--	--	--	--	--
pos_159	"p-Mentha-1,3,5,8-tetraene"	7.45E-05	2.32E-05	4.67E-05	2.08E-05	7.39E-05	6.92E-05	0.000175897	0.000250238	0.000189281	8.71E-05	0.000158171	0.000144432	5.14E-05	0.000167518	3.26	1.705203285	0.001931778	1.2561404	up	0.002164502	--	--	--	--	--	--	--	--
pos_160	"1,2-Dioleoyl-sn-glycerol"	0.001246207	0.001431996	0.000880723	0.001200713	0.000972835	0.001326167	0.00157878	0.001814479	0.001795675	0.001692035	0.001588073	0.002615709	0.00117644	0.001847458	1.57	0.651113991	0.006345716	1.112068617	up	0.002164502	--	--	--	--	--	--	--	--
pos_161	1-ethenyl-4-methoxy-Benzene	1.55E-06	7.02E-07	1.88E-06	1.57E-06	1.10E-06	1.22E-06	4.87E-06	1.08E-05	6.31E-06	1.95E-06	8.17E-06	8.52E-06	1.34E-06	6.77E-06	5.07	2.340657122	0.007483522	1.197378022	up	0.002164502	--	--	--	--	--	--	--	--
pos_162	Probenecid glucuronide	0.003908782	0.007436119	0.00270272	0.005176854	0.00369142	0.0040388	0.00170624	0.001284268	0.00152037	0.001225317	0.002278628	0.00461249	0.004492449	0.002104552	0.47	-1.093988928	0.019731836	1.002689545	down	0.025974026	--	--	--	--	--	--	--	--
pos_164	PG(12:0/16:0)	1.63E-05	2.21E-05	1.18E-05	2.09E-05	5.92E-06	1.57E-05	6.65E-05	6.95E-05	5.94E-05	8.77E-05	9.00E-05	9.74E-05	1.55E-05	7.84E-05	5.07	2.343155264	5.03E-05	1.375546639	up	0.002164502	--	--	--	--	--	--	--	--
pos_165	Chavicol	1.58E-06	0	0	2.55E-07	0	2.60E-07	9.62E-06	6.52E-06	6.24E-06	1.04E-05	6.70E-06	1.21E-05	3.49E-07	8.60E-06	24.6	4.62082307	0.000280674	1.360955551	up	0.004771822	Phenols	C16930	Phenylpropanoid biosynthesis(ko00940)	HMDB0034107	68148	501-92-8	Benzenoids	1-hydroxy-2-unsubstituted benzenoids
pos_166	Acetyl tributyl citrate	0.004962433	0.004750599	0.005093194	0.006492994	0.007337184	0.008517636	0.012928516	0.012309091	0.012519677	0.011923907	0.011556853	0.014229693	0.00619234	0.012577956	2.03	1.022340941	1.80E-05	1.400492886	up	0.002164502	Carboxylic acids and derivatives	--	--	HMDB0034159	6505	77-90-7	Organic acids and derivatives	Tetracarboxylic acids and derivatives
pos_167	Norchelerythrine	0.045678061	0.026869353	0.018508717	0.029061967	0.042201944	0.037272175	0.077810612	0.09302628	0.07000546	0.107105601	0.072784402	0.062383939	0.033265369	0.080519382	2.42	1.275315056	0.000291783	1.293868565	up	0.002164502	--	--	--	--	--	--	--	--
pos_168	p-Cymene	2.94E-05	7.42E-06	1.04E-05	6.82E-06	1.92E-05	1.81E-05	3.86E-05	5.96E-05	3.96E-05	2.21E-05	3.42E-05	3.55E-05	1.52E-05	3.83E-05	2.51	1.329647691	0.004400696	1.145233365	up	0.004329004	Prenol lipids	C06575	Metabolic pathways(ko01100)	HMDB0005805	7463	99-87-6	Lipids and lipid-like molecules	Monoterpenoids
pos_169	N-stearoyl valine	0.000359371	0.000296551	0.000347562	0.000410095	0.000421314	0.000520695	0.000820372	0.000718927	0.000779244	0.000745153	0.000646953	0.000858155	0.000392598	0.000761467	1.94	0.955730185	7.92E-06	1.396426814	up	0.002164502	--	--	--	--	--	--	--	--
pos_174	2-Methoxyhydroquinone	1.13E-05	1.54E-05	6.12E-06	3.05E-06	8.97E-06	7.83E-06	2.86E-05	5.71E-05	7.94E-05	2.32E-05	5.69E-05	6.74E-05	8.78E-06	5.21E-05	5.93	2.568564659	0.004241878	1.218409853	up	0.002164502	--	--	--	--	--	--	--	--
pos_175	"2,6-nonadienoic acid"	8.83E-06	4.68E-06	7.65E-06	1.04E-05	1.15E-05	1.46E-05	2.92E-05	1.35E-05	1.45E-05	1.43E-05	1.60E-05	1.75E-05	9.62E-06	1.75E-05	1.82	0.863409469	0.022324322	1.009626381	up	0.015151515	--	--	--	--	--	--	--	--
pos_176	Mintsulfide	9.06E-07	7.22E-07	8.28E-07	1.45E-07	1.97E-07	2.42E-07	2.06E-06	5.68E-06	3.27E-06	1.13E-06	1.76E-06	2.58E-06	5.07E-07	2.75E-06	5.42	2.439052751	0.018207577	1.107390218	up	0.002164502	--	--	--	--	--	--	--	--
pos_177	3-Phenylpropanal	7.41E-06	9.18E-06	7.79E-06	9.67E-06	7.30E-06	8.43E-06	1.33E-05	1.36E-05	1.02E-05	1.26E-05	8.39E-06	1.27E-05	8.30E-06	1.18E-05	1.42	0.509145925	0.006527337	1.180310734	up	0.015151515	Benzene and substituted derivatives	--	--	HMDB0033716	7707	104-53-0	Benzenoids	--
pos_178	4-Methylcatechol	0.000455196	0.000275478	0.000294646	0.000596125	0.001088318	0.000847114	0.000116293	0.000109055	8.13E-05	8.31E-05	0.000116362	0.000154463	0.000592813	0.000110096	0.19	-2.428814774	0.014270591	1.106678711	down	0.002164502	Phenols	C06730	Metabolic pathways(ko01100)	HMDB0000873	9958	452-86-8	Benzenoids	Benzenediols
pos_179	Isoeugenol	5.71E-06	0	0	0	0	0	1.56E-05	2.42E-05	3.43E-06	4.31E-06	8.36E-06	2.91E-05	9.52E-07	1.42E-05	14.88	3.89572937	0.028373466	1.02472333	up	0.010064562	Phenols	C10469	Phenylpropanoid biosynthesis(ko00940)	HMDB0005802	853433	5932-68-3	Benzenoids	Methoxyphenols
pos_180	"2,6Z-Nonadien-4-olide"	7.60E-05	3.75E-05	3.51E-05	4.29E-05	7.10E-05	4.98E-05	0.0002587	0.000240955	0.000273218	0.000447358	0.000425471	0.00035185	5.20E-05	0.000332925	6.4	2.677710852	0.000451376	1.323059863	up	0.002164502	--	--	--	--	--	--	--	--
pos_182	YM-53601	2.05E-05	8.04E-06	3.39E-06	7.77E-06	1.60E-05	1.50E-05	0	8.72E-07	8.71E-06	2.50E-06	3.65E-06	5.22E-06	1.18E-05	3.49E-06	0.3	-1.753976182	0.023761777	1.029038647	down	0.041125541	--	--	--	--	--	--	--	--
pos_183	(4-Methylphenyl)acetaldehyde	7.39E-05	7.31E-05	7.63E-05	8.97E-05	7.21E-05	8.20E-05	0.000141711	0.000107171	0.000122706	0.000137713	9.38E-05	0.000146102	7.78E-05	0.00012487	1.6	0.681714801	0.001886218	1.281246463	up	0.002164502	--	--	--	--	--	--	--	--
pos_185	Methyldopate	0.003010323	0.005187067	0.000934192	0.003502371	0.002715234	0.003061999	0.01570065	0.014371279	0.013235315	0.018678303	0.017104422	0.028170437	0.003068531	0.017876734	5.83	2.542463091	0.000800546	1.307394854	up	0.002164502	Phenylpropanoic acids	--	--	HMDB0011754	38853	555-30-6	Phenylpropanoids and polyketides	--
pos_186	AS 1-5	0.00230686	0.002682615	0.002780993	0.003700974	0.00275922	0.004152456	0.008795913	0.007552884	0.00988286	0.013719235	0.007616375	0.014329746	0.003063853	0.010316169	3.37	1.751488293	0.001565052	1.285673415	up	0.002164502	--	--	--	--	--	--	--	--
pos_187	Ochratoxin A	0.018398396	0.025642212	0.012292155	0.02714955	0.019488725	0.030556535	0.00583704	0.009502678	0.010569189	0.008301824	0.006320555	0.005151861	0.022254596	0.007613858	0.34	-1.547403765	0.002240612	1.239052243	down	0.002164502	--	--	--	--	--	--	--	--
pos_189	1-ACETYLPIPERIDINE	2.44E-05	2.38E-05	2.43E-05	3.08E-05	3.11E-05	3.86E-05	5.12E-05	4.67E-05	6.11E-05	5.60E-05	4.66E-05	7.10E-05	2.88E-05	5.54E-05	1.92	0.943001565	0.000322475	1.302212237	up	0.002164502	--	--	--	--	--	--	--	--
pos_190	S-Adenosylhomocysteine-d4	0.000849916	0.000806773	0.000624785	0.000690203	0.000763884	0.000778414	0.001575055	0.002079634	0.001349793	0.001122896	0.001456586	0.001767482	0.000752329	0.001558574	2.07	1.050791047	0.001548766	1.308318626	up	0.002164502	--	--	--	--	--	--	--	--
pos_193	"2E,7-Octadienal"	3.32E-06	3.75E-06	3.05E-06	3.42E-06	4.06E-06	7.40E-06	9.69E-06	7.50E-06	1.88E-05	9.87E-06	7.90E-06	1.76E-05	4.16E-06	1.19E-05	2.86	1.513809372	0.011081086	1.111562266	up	0.002164502	--	--	--	--	--	--	--	--
pos_195	4-n-Butylresorcinol	8.31E-05	4.95E-05	5.18E-05	6.02E-05	9.80E-05	8.38E-05	4.91E-06	3.87E-06	1.73E-06	4.07E-06	2.45E-06	5.72E-06	7.11E-05	3.79E-06	0.05	-4.227350968	0.000405126	1.382259011	down	0.002164502	--	--	--	--	--	--	--	--
pos_196	"(E,E)-2,4-Decadienoic isobutylamide"	2.42E-05	2.23E-05	2.18E-05	2.48E-05	2.49E-05	2.90E-05	4.22E-05	3.42E-05	3.61E-05	3.18E-05	3.37E-05	4.00E-05	2.45E-05	3.63E-05	1.48	0.567435467	0.000223968	1.326379867	up	0.002164502	--	--	--	--	--	--	--	--
pos_197	"2,4,6-Trimethylacetophenone imine"	1.83E-05	1.49E-05	1.67E-05	2.01E-05	1.72E-05	2.01E-05	2.91E-05	2.44E-05	2.81E-05	2.18E-05	2.03E-05	2.94E-05	1.79E-05	2.55E-05	1.43	0.51276519	0.003210829	1.219164448	up	0.004998125	--	--	--	--	--	--	--	--
pos_198	3-Methylbutyraldehyde oxime	0.000218564	0.000216714	0.000224398	0.000232443	0.000234338	0.000239292	0.000338487	0.000314563	0.00031466	0.000280421	0.000246735	0.000329689	0.000227625	0.000304092	1.34	0.417851544	0.002212626	1.307847043	up	0.002164502	--	C17255	Glucosinolate biosynthesis(ko00966);;2-Oxocarboxylic acid metabolism(ko01210);;Biosynthesis of secondary metabolites(ko01110)	--	--	--	--	--
pos_201	Phenylpropylmethylamine	4.98E-06	3.48E-06	4.61E-06	6.27E-06	5.73E-06	5.16E-06	1.03E-05	7.00E-06	7.79E-06	8.16E-06	6.88E-06	9.35E-06	5.04E-06	8.25E-06	1.64	0.711246951	0.001042348	1.248414261	up	0.002164502	--	--	--	--	--	--	--	--
pos_204	(Z)-4-(1-Propenyl)phenol	1.22E-05	6.23E-06	6.48E-06	6.13E-06	1.12E-05	7.15E-06	2.16E-07	2.59E-06	0	1.62E-06	3.82E-07	2.14E-07	8.23E-06	8.36E-07	0.1	-3.299647326	0.000626302	1.329641848	down	0.002164502	--	--	--	--	--	--	--	--
pos_205	LAWSONE	0.000210085	0.000203295	0.000337568	0.000265185	0.000297349	0.000315126	0.000150664	0.000186299	0.000182973	0.000143854	0.000133046	0.000114166	0.000271435	0.000151834	0.56	-0.838113043	0.001872621	1.175899522	down	0.002164502	Naphthalenes	--	--	HMDB0030773	3806	481-39-0	Benzenoids	Naphthoquinones
pos_207	Glycerol 2-phosphate	3.02E-05	7.47E-05	2.71E-05	7.56E-05	5.27E-05	6.57E-05	0.000227437	0.000113313	0.000226663	7.66E-05	0.000145288	0.000327169	5.43E-05	0.000186082	3.43	1.776259596	0.015989452	1.090423405	up	0.002164502	Glycerophospholipids	--	--	HMDB0002520	2526	17181-54-3	Lipids and lipid-like molecules	Glycerophosphates
pos_209	Orsellinic acid	4.07E-06	3.06E-06	8.53E-06	3.62E-06	6.44E-06	6.36E-06	1.44E-06	1.64E-06	5.07E-10	6.39E-07	1.05E-07	2.82E-07	5.35E-06	6.84E-07	0.13	-2.96533344	0.002041964	1.223368214	down	0.002164502	--	--	--	--	--	--	--	--
pos_210	"N,N-Dimethylaniline"	0.001068894	0.001010894	0.001138523	0.00124663	0.001211658	0.001322533	0.001913897	0.001656211	0.001745944	0.001622483	0.001427425	0.001851132	0.001166522	0.001702849	1.46	0.545736674	0.000171773	1.351026894	up	0.002164502	--	--	--	--	--	--	--	--
pos_212	hydrocinnamic acid	1.47E-05	1.50E-05	1.52E-05	1.65E-05	1.44E-05	1.62E-05	2.99E-05	2.06E-05	2.46E-05	2.55E-05	2.04E-05	2.83E-05	1.53E-05	2.49E-05	1.62	0.699016268	0.00152282	1.31123614	up	0.002164502	Phenylpropanoic acids	C05629	Metabolic pathways(ko01100);;Phenylalanine metabolism(ko00360)	HMDB0000764	107	501-52-0	Phenylpropanoids and polyketides	--
pos_213	Multifidol	0.000662079	0.000142923	0.000549557	0.000105313	0.000482606	0.000555494	7.68E-06	3.29E-06	3.20E-06	3.28E-07	4.25E-06	1.70E-05	0.000416329	5.96E-06	0.01	-6.125744383	0.007712179	1.198103642	down	0.002164502	--	--	--	--	--	--	--	--
pos_214	o-Toluidine	1.12E-06	1.26E-06	6.09E-07	1.31E-06	1.70E-06	1.29E-06	2.54E-06	2.74E-06	3.13E-06	2.22E-06	2.96E-06	3.24E-06	1.22E-06	2.80E-06	2.31	1.205615456	2.18E-05	1.348878787	up	0.002164502	--	--	--	--	--	--	--	--
pos_217	"2,6-Diethylaniline"	5.22E-06	4.40E-06	5.19E-06	6.04E-06	6.13E-06	6.48E-06	8.86E-06	8.83E-06	8.84E-06	6.82E-06	5.90E-06	9.12E-06	5.58E-06	8.06E-06	1.45	0.531873877	0.00453183	1.200676555	up	0.015151515	--	--	--	--	--	--	--	--
pos_218	beta-Ionone	1.73E-06	2.64E-06	2.62E-06	3.21E-06	2.48E-06	3.41E-06	6.50E-06	7.62E-06	8.98E-06	4.33E-06	4.99E-06	6.87E-06	2.68E-06	6.55E-06	2.44	1.288998675	0.001738806	1.302699152	up	0.002164502	--	--	--	--	--	--	--	--
pos_219	Dicyclopentadiene	3.70E-05	1.32E-05	2.29E-05	1.28E-05	3.09E-05	3.55E-05	0.000113651	0.000205911	0.000106513	5.35E-05	0.000135827	0.000107982	2.54E-05	0.00012057	4.75	2.248578843	0.004793942	1.233471581	up	0.002164502	--	--	--	--	--	--	--	--
pos_221	"7,9-decadienoic acid"	0.000145728	1.00E-04	8.70E-05	8.44E-05	0.000128471	0.000171021	3.14E-05	4.32E-05	3.64E-05	8.08E-05	1.15E-05	5.66E-05	0.000119437	4.33E-05	0.36	-1.463360608	0.001759962	1.208907119	down	0.002164502	--	--	--	--	--	--	--	--
pos_222	Confertifoline	0.00036686	0.000358407	0.000405114	0.000430739	0.000418271	0.000454287	0.000691903	0.000609504	0.000616724	0.000596476	0.000530895	0.000653484	0.000405613	0.000616498	1.52	0.603991981	2.93E-05	1.398993263	up	0.002164502	--	--	--	--	--	--	--	--
pos_223	DMPO	7.70E-06	1.09E-05	9.93E-06	9.25E-06	8.88E-06	1.66E-05	1.41E-05	1.55E-05	2.21E-05	1.51E-05	1.22E-05	1.94E-05	1.05E-05	1.64E-05	1.56	0.638168057	0.014105375	1.03828948	up	0.025974026	--	--	--	--	--	--	--	--
pos_228	6-Methylquinoline	9.87E-06	1.04E-05	1.11E-05	1.19E-05	9.70E-06	1.23E-05	1.60E-05	1.52E-05	1.57E-05	1.31E-05	1.18E-05	1.55E-05	1.09E-05	1.46E-05	1.34	0.420864202	0.001896203	1.259236182	up	0.008658009	--	--	--	--	--	--	--	--
pos_229	2-Methylpropanamine	1.62E-05	1.58E-05	2.08E-05	2.21E-05	2.20E-05	1.96E-05	3.26E-05	2.79E-05	2.44E-05	2.59E-05	2.39E-05	2.94E-05	1.94E-05	2.74E-05	1.41	0.495103978	0.001277429	1.251367985	up	0.002164502	Organonitrogen compounds	--	--	HMDB0034198	6558	78-81-9	Organic nitrogen compounds	Amines
pos_230	(S)-(-)-Perillyl alcohol	2.45E-05	2.68E-05	2.43E-05	3.20E-05	2.27E-05	3.90E-05	7.57E-05	4.41E-05	6.77E-05	4.13E-05	6.19E-05	4.69E-05	2.82E-05	5.63E-05	1.99	0.99490192	0.003138695	1.213217411	up	0.002164502	Prenol lipids	C02452	Biosynthesis of secondary metabolites(ko01110);;Monoterpenoid biosynthesis(ko00902);;Limonene and pinene degradation(ko00903)	HMDB0003634	10819	536-59-4	Lipids and lipid-like molecules	Monoterpenoids
pos_232	Glycidyl oleate	4.56E-05	8.02E-05	6.19E-05	0.000110003	0.000103691	0.00016395	0.000246527	0.000264214	0.000200529	0.000235697	0.000181952	0.000225161	9.42E-05	0.00022568	2.4	1.260125889	0.000147824	1.348413627	up	0.002164502	--	--	--	--	--	--	--	--
pos_233	Danielone	3.03E-05	3.29E-05	3.39E-05	3.99E-05	4.58E-05	4.90E-05	6.66E-05	6.19E-05	5.96E-05	5.60E-05	5.44E-05	6.34E-05	3.87E-05	6.03E-05	1.56	0.641260781	0.000283867	1.336726069	up	0.002164502	--	--	--	--	--	--	--	--
pos_234	Leptodactylone	0.001353566	0.000612634	0.001076581	0.000575319	0.001462889	0.00166644	0.001930594	0.002097032	0.001463927	0.002144119	0.001350586	0.002091146	0.001124571	0.001846234	1.64	0.715210082	0.01231347	1.042297713	up	0.025974026	--	--	--	--	--	--	--	--
pos_238	Ser Tyr Arg	0.013381798	0.011913137	0.015079291	0.01844904	0.019940909	0.025730721	0.036444196	0.033407239	0.036514002	0.032905837	0.030308986	0.040330251	0.017415816	0.034985085	2.01	1.006341939	6.86E-05	1.364060389	up	0.002164502	--	--	--	--	--	--	--	--
pos_239	"2',4'-Dihydroxy-2,3',6'-trimethoxychalcone"	0.001619468	0.001538892	0.003095381	0.001987941	0.002060681	0.001814926	0.001173359	0.001308659	0.001225573	0.001275834	0.00098312	0.000886698	0.002019548	0.001142207	0.57	-0.822208139	0.011089321	1.071605523	down	0.002164502	--	--	--	--	--	--	--	--
pos_242	4-octenedial	2.56E-05	9.42E-06	7.75E-06	7.86E-06	1.64E-05	1.33E-05	2.78E-05	4.09E-05	2.42E-05	4.14E-05	3.65E-05	3.31E-05	1.34E-05	3.40E-05	2.54	1.344993617	0.000424579	1.226370706	up	0.004329004	--	--	--	--	--	--	--	--
pos_243	Taraxasterol	1.22E-05	5.93E-07	1.32E-06	1.95E-06	2.90E-07	2.14E-06	1.83E-05	0.000109328	0.000138451	0.000161288	0.000101698	0.000154397	3.09E-06	0.000113917	36.89	5.204965344	0.003463085	1.233795261	up	0.002164502	--	--	--	--	--	--	--	--
pos_250	"4,2'-Dihydroxy-3',4',6'-trimethoxychalcone"	0.000484682	0.000292654	0.001146377	0.000386232	0.000558866	0.000453477	5.24E-05	8.42E-05	9.28E-05	6.94E-05	4.50E-05	3.48E-05	0.000553715	6.31E-05	0.11	-3.133845411	0.010705143	1.127339639	down	0.002164502	--	--	--	--	--	--	--	--
pos_251	"2,5-Furandicarboxaldehyde"	0.004227696	0.004361467	0.010343715	0.007790592	0.006663939	0.007180254	0.014792548	0.021868067	0.014394637	0.013839398	0.012594201	0.006149746	0.006761277	0.013939766	2.06	1.043838699	0.015440073	1.101413989	up	0.025974026	--	--	--	--	--	--	--	--
pos_253	2-Methyl-2-cyclopenten-1-one	7.34E-06	1.36E-06	0	6.21E-06	4.52E-06	8.16E-06	0	0	0	0	0	8.80E-07	4.60E-06	1.47E-07	0.03	-4.969833428	0.021099328	1.069062321	down	0.016711445	--	--	--	--	--	--	--	--
pos_254	ARCAINE	0.000134325	9.92E-05	0.000156543	0.000154166	0.000188964	0.000181424	7.17E-05	8.86E-05	9.76E-05	9.93E-05	6.97E-05	9.35E-05	0.000152433	8.67E-05	0.57	-0.813499178	0.003072148	1.187361721	down	0.004329004	--	--	--	--	--	--	--	--
pos_257	"2E,4Z-Heptadienal"	2.61E-06	3.02E-06	1.59E-06	1.51E-06	2.87E-06	7.48E-06	8.58E-06	8.01E-06	2.14E-05	1.43E-05	1.07E-05	2.14E-05	3.18E-06	1.40E-05	4.42	2.143094519	0.005653017	1.155244831	up	0.004998125	--	--	--	--	--	--	--	--
pos_258	"cis-1,2-Dihydroxy-1,2-dihydrodibenzothiophene"	5.57E-06	5.52E-06	6.24E-06	6.57E-06	6.15E-06	6.86E-06	8.01E-06	8.32E-06	1.11E-05	1.10E-05	8.62E-06	8.98E-06	6.15E-06	9.34E-06	1.52	0.60168933	0.001380594	1.267315477	up	0.002164502	--	--	--	--	--	--	--	--
pos_263	"9S,10R-Epoxy-6Z-octadecene"	6.26E-06	1.21E-05	7.47E-06	8.78E-06	6.15E-06	6.68E-06	0.00014983	0.000136698	0.000117134	9.31E-05	9.63E-05	0.000142023	7.90E-06	0.000122512	15.51	3.955099457	7.52E-05	1.439834677	up	0.002164502	--	--	--	--	--	--	--	--
pos_267	3-(4-Methylphenyl)-2-propenal	4.15E-06	4.16E-06	5.07E-06	3.82E-06	5.47E-06	4.29E-06	6.95E-06	7.48E-06	7.20E-06	5.77E-06	6.18E-06	6.60E-06	4.49E-06	6.70E-06	1.49	0.57583079	0.000135635	1.331241424	up	0.002164502	--	--	--	--	--	--	--	--
pos_270	"3,4-Dihydroxystyrene"	0.001685599	0.001933368	0.001842802	0.002029202	0.002308823	0.00237837	0.000547683	0.000437281	0.000580796	0.000495299	0.000479269	0.000519914	0.002029694	0.00051004	0.25	-1.992578901	2.34E-05	1.426778272	down	0.002164502	Phenols	C06224	Phenylpropanoid biosynthesis(ko00940)	HMDB0124942	151398	--	Benzenoids	Benzenediols
pos_271	4-Methylphenyl acetone	2.11E-05	1.04E-05	1.54E-05	1.23E-05	2.14E-05	1.96E-05	1.74E-06	1.88E-06	1.36E-06	1.08E-06	7.38E-07	1.62E-06	1.67E-05	1.40E-06	0.08	-3.573784349	0.000488671	1.372277516	down	0.002164502	--	--	--	--	--	--	--	--
pos_273	eugenol	1.38E-05	8.87E-06	8.60E-06	6.46E-06	1.53E-05	9.04E-06	0	0	0	0	1.00E-06	0	1.04E-05	1.67E-07	0.02	-5.952805411	0.000711416	1.372603469	down	0.003664548	Phenols	C10453	Phenylpropanoid biosynthesis(ko00940)	HMDB0005809	3314	97-53-0	Benzenoids	Methoxyphenols
pos_275	"2,4-heptadienal"	2.46E-05	2.32E-05	6.11E-06	1.14E-05	2.05E-05	2.00E-05	6.50E-07	1.27E-07	2.40E-07	4.88E-06	1.59E-06	1.68E-05	1.76E-05	4.05E-06	0.23	-2.123273653	0.006754094	1.125116011	down	0.008658009	--	--	--	--	--	--	--	--
pos_276	6-Methoxyflavone	0.000801389	0.00076001	0.001434124	0.000874116	0.000974154	0.000969336	0.000535452	0.000710334	0.000478552	0.000527298	0.000382108	0.00031972	0.000968855	0.000492244	0.51	-0.976906914	0.003213035	1.129502094	down	0.002164502	--	--	--	--	--	--	--	--
pos_277	2-Furanmethanol	2.17E-05	2.29E-05	9.78E-06	1.52E-05	2.31E-05	2.27E-05	4.96E-06	6.19E-06	3.75E-06	1.01E-05	6.12E-06	1.07E-05	1.92E-05	6.97E-06	0.36	-1.463600754	0.001580398	1.266076506	down	0.008658009	Heteroaromatic compounds	--	--	HMDB0013742	7361	98-00-0	Organoheterocyclic compounds	--
pos_278	Ethyl 2-furanpropionate	0.000724821	0.000268382	0.000644613	0.000258556	0.000598693	0.000647606	0.000191434	0.000209079	0.000182651	0.000162426	0.0001521	0.000155399	0.000523778	0.000175515	0.34	-1.57736247	0.008698857	1.172771514	down	0.002164502	--	--	--	--	--	--	--	--
pos_280	Tetrahydrofurfuryl cinnamate	3.73E-05	3.91E-05	5.37E-05	3.44E-05	2.91E-05	3.32E-05	4.21E-06	1.91E-05	4.64E-06	2.15E-06	3.37E-06	3.07E-06	3.78E-05	6.08E-06	0.16	-2.63563549	3.90E-05	1.330141233	down	0.002164502	--	--	--	--	--	--	--	--
pos_283	Benzoximate	0.000395511	0.00047181	0.00055561	0.00051048	0.000425115	0.00048903	0.000166435	0.000144464	0.000149984	0.000110596	0.000101593	0.000158166	0.000474593	0.00013854	0.29	-1.776390604	3.89E-06	1.409009245	down	0.002164502	--	--	--	--	--	--	--	--
pos_286	Pentedrone	7.63E-05	4.52E-05	4.01E-05	3.79E-05	8.71E-05	6.49E-05	2.25E-05	2.49E-05	3.05E-05	3.01E-05	3.07E-05	3.67E-05	5.86E-05	2.92E-05	0.5	-1.003829716	0.016206526	1.115759353	down	0.002164502	--	--	--	--	--	--	--	--
pos_288	1-Monopalmitin	0.000578391	0.000316192	0.000598936	0.000684498	0.000899596	0.001200628	0.001711434	0.001498788	0.001986109	0.001786019	0.001858622	0.002237846	0.00071304	0.00184647	2.59	1.372713981	4.23E-05	1.341704946	up	0.002164502	Glycerolipids	--	--	HMDB0011564	3084463	32899-41-5	Lipids and lipid-like molecules	Monoradylglycerols
pos_291	Bellendine	1.76E-06	4.23E-06	2.22E-06	3.80E-06	2.94E-06	3.52E-06	5.49E-05	4.80E-06	2.98E-05	3.11E-05	2.22E-05	7.83E-05	3.08E-06	3.68E-05	11.97	3.580983339	0.024286552	1.039806809	up	0.002164502	--	--	--	--	--	--	--	--
pos_293	Dihydroartemisinin	3.10E-05	2.27E-05	1.58E-05	3.81E-05	5.32E-05	5.66E-05	0.000151268	6.93E-05	6.24E-05	0.000136765	6.85E-05	8.41E-05	3.62E-05	9.54E-05	2.63	1.396148169	0.011289477	1.096661917	up	0.002164502	Prenol lipids	--	--	HMDB0060593	456410	81496-81-3	Lipids and lipid-like molecules	Sesquiterpenoids
pos_297	"1,3,5-TRIMETHOXYBENZENE"	6.98E-06	4.84E-06	5.32E-06	6.45E-06	6.27E-06	1.08E-05	1.51E-05	1.36E-05	1.12E-05	1.66E-05	1.04E-05	1.82E-05	6.78E-06	1.42E-05	2.09	1.064458205	0.000940918	1.245176722	up	0.004329004	--	--	--	--	--	--	--	--
pos_298	Coumarin	0.003465599	0.000923598	0.003127279	0.000918623	0.003018809	0.002822696	0.000853736	0.00042817	0.000820564	0.00044159	0.000658569	0.000768546	0.002379434	0.000661862	0.28	-1.846015081	0.013989938	1.119280511	down	0.002164502	Coumarins and derivatives	C05851	Biosynthesis of secondary metabolites(ko01110);;Phenylpropanoid biosynthesis(ko00940)	HMDB0001218	323	91-64-5	Phenylpropanoids and polyketides	--
pos_299	4-Acetyl-1-methylcyclohexene	5.03E-06	2.56E-06	7.97E-06	4.72E-06	9.60E-06	7.38E-06	2.54E-06	3.26E-06	4.09E-06	2.26E-06	2.66E-06	1.02E-06	6.21E-06	2.64E-06	0.42	-1.235380424	0.017176074	1.015554229	down	0.015151515	Organooxygen compounds	--	--	HMDB0033434	93019	6090/9/1	Organic oxygen compounds	Carbonyl compounds
pos_301	(-)-Corey Lactone Diol	0.00054912	0.000600127	0.000293254	0.000460545	0.000551988	0.000536355	0.000172529	0.000238826	0.000267237	0.000344165	0.000252218	0.000393802	0.000498565	0.00027813	0.56	-0.842025031	0.003154305	1.194111821	down	0.008658009	--	--	--	--	--	--	--	--
pos_303	Cyclocalopin F	8.34E-05	9.13E-05	9.26E-05	0.000101182	7.99E-05	9.04E-05	0.000149626	0.000111711	0.000130402	0.000145254	0.00010303	0.000145082	8.98E-05	0.000130851	1.46	0.543225731	0.002441068	1.251909343	up	0.002164502	--	--	--	--	--	--	--	--
pos_305	2-(4-Hydroxyphenyl)ethanol	0.001253924	0.000582972	0.000174285	0.000278435	0.001110495	0.000550446	0.00010894	8.21E-05	0.000130888	0.000136764	9.18E-05	0.000175978	0.000658426	0.000121078	0.18	-2.443083548	0.029561799	1.061937671	down	0.004329004	Phenols	C06044	Tyrosine metabolism(ko00350);;Metabolic pathways(ko01100)	HMDB0004284	10393	501-94-0	Benzenoids	Tyrosols and derivatives
pos_308	15(S)-15-methyl PGF2α isopropyl ester	1.79E-05	1.08E-05	1.24E-05	1.74E-05	1.84E-05	3.53E-05	6.60E-05	3.96E-05	7.65E-05	5.04E-05	3.32E-05	4.21E-05	1.87E-05	5.13E-05	2.74	1.455474659	0.003298765	1.205314217	up	0.004329004	--	--	--	--	--	--	--	--
pos_309	"Cer(d16:2(4E,6E)/18:1(9Z)(2OH))"	1.18E-05	1.02E-05	1.35E-05	1.75E-05	1.82E-05	2.44E-05	2.84E-05	2.90E-05	3.73E-05	3.83E-05	2.63E-05	5.49E-05	1.59E-05	3.57E-05	2.24	1.164738115	0.004267059	1.170817199	up	0.002164502	--	--	--	--	--	--	--	--
pos_312	4-(Butoxymethyl)phenol	3.51E-08	1.21E-07	2.30E-08	2.00E-08	1.45E-07	4.22E-08	1.10E-05	1.67E-05	9.00E-06	9.87E-06	6.89E-06	1.15E-05	6.44E-08	1.08E-05	167.89	7.391403495	0.00050598	1.397084649	up	0.002164502	--	--	--	--	--	--	--	--
pos_313	"1,2,4,5-Tetramethylbenzene"	8.70E-05	3.34E-05	2.95E-05	2.73E-05	5.98E-05	4.41E-05	1.75E-05	1.20E-05	1.39E-05	1.51E-05	2.03E-05	2.63E-05	4.68E-05	1.75E-05	0.37	-1.418804851	0.02526493	1.072020738	down	0.002164502	--	--	--	--	--	--	--	--
pos_314	4-hydroxy Nonenal Alkyne	1.09E-05	7.47E-06	9.42E-06	1.40E-05	1.35E-05	1.75E-05	3.71E-05	2.13E-05	2.17E-05	2.53E-05	2.15E-05	2.73E-05	1.21E-05	2.57E-05	2.12	1.082032445	0.00151874	1.244077516	up	0.002164502	--	--	--	--	--	--	--	--
pos_317	[2-(Dimethoxymethyl)-1-heptenyl]benzene	0.000127039	0.000119838	0.000125756	0.000145203	0.000144192	0.000161915	0.000222164	0.000206527	0.000202395	0.000200631	0.000173199	0.00022557	0.000137324	0.000205081	1.49	0.578610211	5.70E-05	1.364804561	up	0.002164502	--	--	--	--	--	--	--	--
pos_320	Cinncassiol C3	6.70E-06	6.60E-06	5.69E-06	6.60E-06	7.59E-06	9.21E-06	1.37E-05	1.31E-05	1.18E-05	1.66E-05	9.36E-06	1.46E-05	7.07E-06	1.32E-05	1.87	0.900509973	0.00081115	1.288400977	up	0.004998125	--	--	--	--	--	--	--	--
pos_321	Phenylcyclohexylglycolic acid	3.77E-05	3.25E-05	2.98E-05	4.70E-05	3.70E-05	3.83E-05	7.16E-05	6.50E-05	5.44E-05	6.20E-05	5.60E-05	7.11E-05	3.71E-05	6.33E-05	1.71	0.773226352	5.44E-05	1.356492661	up	0.002164502	--	--	--	--	--	--	--	--
pos_323	(R)-N-Methylsalsolinol	6.30E-05	5.10E-05	2.69E-05	3.89E-05	5.66E-05	5.83E-05	7.56E-05	8.43E-05	6.25E-05	9.08E-05	7.59E-05	0.000135528	4.91E-05	8.74E-05	1.78	0.832563571	0.01231634	1.03028575	up	0.004329004	--	--	--	--	--	--	--	--
pos_324	"1-Methoxy-2,4-dimethylbenzene"	2.17E-06	1.55E-06	2.42E-06	0	4.43E-06	3.60E-06	6.98E-06	6.10E-06	6.14E-06	7.55E-06	6.39E-06	3.68E-06	2.36E-06	6.14E-06	2.6	1.377722319	0.001170275	1.202833464	up	0.004329004	--	--	--	--	--	--	--	--
pos_325	3-Methylbutyl phenylacetate	2.25E-05	8.77E-06	2.57E-05	1.01E-05	3.29E-05	3.20E-05	5.46E-05	7.35E-05	4.69E-05	2.29E-05	5.44E-05	7.06E-05	2.20E-05	5.38E-05	2.45	1.290678474	0.006119096	1.14323472	up	0.015151515	--	--	--	--	--	--	--	--
pos_330	Poriol	0.00061781	0.000369326	0.000373151	0.000713925	0.000957444	0.001121485	0.000247579	0.000129593	0.000137089	0.000111299	0.000204416	0.000367492	0.00069219	0.000199578	0.29	-1.794215102	0.009354396	1.120770619	down	0.002164502	--	--	--	--	--	--	--	--
pos_332	"(1R,4R,5S)-5-Hydroxyfenchone glucoside"	0.005972359	0.00407197	0.006587902	0.006162268	0.008092959	0.006785338	0.000476436	0.000443954	0.001031443	0.001038277	0.000339303	0.000709057	0.006278799	0.000673078	0.11	-3.221642975	8.56E-05	1.399200653	down	0.002164502	--	--	--	--	--	--	--	--
pos_333	Ascaridole	0.000202278	0.000138188	0.000169262	0.000169308	0.00025655	0.000231329	4.85E-05	5.34E-05	6.79E-05	7.84E-05	3.17E-05	6.99E-05	0.000194486	5.83E-05	0.3	-1.738477507	0.000288771	1.34287059	down	0.002164502	--	--	--	--	--	--	--	--
pos_334	Phe Tyr Met Cys	0.002790765	0.004410888	0.007870045	0.004295574	0.002610057	0.002476418	0.000802696	0.00069012	0.000629239	0.000410014	0.000544385	0.000529792	0.004075625	0.000601041	0.15	-2.761485662	0.008723167	1.147388424	down	0.002164502	--	--	--	--	--	--	--	--
pos_336	"3,4-Dihydroxyphenyl ethanol"	0.001067151	0.000759222	0.000654388	0.000583595	0.000886751	0.000797062	0.00128089	0.00141033	0.00086584	0.001088462	0.000971565	0.001714378	0.000791362	0.001221911	1.54	0.626729985	0.018874757	1.002643057	up	0.015151515	--	--	--	--	--	--	--	--
pos_338	Glycerol 1-(5-hydroxydodecanoate)	0.000287499	0.000210277	0.000214096	0.000222167	0.00030815	0.00031367	0.000379025	0.000352937	0.000345928	0.000390598	0.000463331	0.000507934	0.00025931	0.000406626	1.57	0.649024631	0.001500585	1.164476304	up	0.002164502	--	--	--	--	--	--	--	--
pos_339	Sodium (±)-2-(4-methoxyphenoxy)propionate	9.88E-05	0.000100281	0.000164171	0.000105727	0.000112187	0.000106991	8.17E-05	7.82E-05	7.42E-05	6.66E-05	6.50E-05	7.77E-05	0.000114695	7.39E-05	0.64	-0.6339533	0.00871601	1.105133066	down	0.002164502	--	--	--	--	--	--	--	--
pos_340	"7',8'-Dihydro-8'-hydroxyreticulataxanthin"	1.74E-06	8.60E-07	2.31E-06	2.98E-06	3.78E-06	2.24E-06	2.17E-05	3.36E-05	2.40E-05	1.40E-05	7.38E-06	2.98E-05	2.32E-06	2.18E-05	9.38	3.229370764	0.004445199	1.27764702	up	0.002164502	--	--	--	--	--	--	--	--
pos_341	ALPRENOLOL	1.41E-05	1.48E-05	2.05E-05	2.80E-05	2.88E-05	5.88E-05	7.92E-05	7.24E-05	0.000134063	0.000106519	9.55E-05	0.000161405	2.75E-05	0.000108195	3.93	1.975635424	0.001093213	1.254263163	up	0.002164502	--	--	--	--	--	--	--	--
pos_342	Precocene II	4.48E-05	4.77E-05	4.80E-05	5.10E-05	5.45E-05	5.33E-05	8.40E-05	7.68E-05	7.43E-05	7.11E-05	6.69E-05	7.82E-05	4.99E-05	7.52E-05	1.51	0.592567385	1.47E-05	1.416986374	up	0.002164502	--	--	--	--	--	--	--	--
pos_343	cyclohexylammonium	4.61E-06	6.07E-06	6.87E-06	5.09E-06	6.99E-06	7.10E-06	8.50E-06	7.22E-06	8.25E-06	6.75E-06	7.48E-06	8.89E-06	6.12E-06	7.85E-06	1.28	0.358644791	0.011079565	1.067025824	up	0.015151515	--	--	--	--	--	--	--	--
pos_344	(+)-alpha-thujene	0	0	0	0	0	0	5.64E-06	1.75E-05	2.98E-06	4.08E-06	5.88E-06	6.19E-06	0	7.05E-06	Inf	Inf	0.022148444	1.096207345	up	0.00277843	--	--	--	--	--	--	--	--
pos_347	4-n-Butylphenol	5.97E-06	5.64E-07	4.69E-06	9.46E-07	8.19E-06	7.87E-06	0	8.21E-07	9.10E-07	0	0	0	4.71E-06	2.88E-07	0.06	-4.028174858	0.022016097	1.052239538	down	0.011518904	--	--	--	--	--	--	--	--
pos_350	Cymorcin monoglucoside	0.000777857	0.000404171	0.000683472	0.000497008	0.000812688	0.000721703	0.0001162	0.000120494	0.000156784	0.000145633	0.000134948	0.000145366	0.000649483	0.000136571	0.21	-2.249642454	0.000552203	1.367798332	down	0.002164502	--	--	--	--	--	--	--	--
pos_351	Santene hydrate	5.12E-06	4.15E-06	6.20E-06	5.49E-06	8.69E-06	6.65E-06	0	0	0	0	0	0	6.05E-06	0	0	#NAME?	0.000216629	1.390415063	down	0.00277843	--	--	--	--	--	--	--	--
pos_352	3-Butyn-1-al	8.42E-06	7.74E-06	1.56E-05	1.28E-05	1.23E-05	1.21E-05	2.25E-05	2.91E-05	2.02E-05	1.84E-05	1.85E-05	8.58E-06	1.15E-05	1.96E-05	1.7	0.766435182	0.030884346	1.01747826	up	0.025974026	Organooxygen compounds	C06145	Butanoate metabolism(ko00650)	HMDB0006853	142966	52844-23-2	Organic oxygen compounds	Carbonyl compounds
pos_353	Arlatin	9.94E-06	7.26E-06	6.90E-06	1.32E-05	1.38E-05	1.66E-05	3.57E-05	2.07E-05	1.82E-05	2.80E-05	1.79E-05	2.20E-05	1.13E-05	2.37E-05	2.1	1.072303651	0.005103067	1.161822316	up	0.002164502	--	--	--	--	--	--	--	--
pos_354	alpha-Valerenol	9.41E-06	1.02E-05	8.40E-06	1.41E-05	1.53E-05	3.36E-05	4.09E-05	3.57E-05	8.25E-05	6.13E-05	5.80E-05	9.66E-05	1.52E-05	6.25E-05	4.12	2.042819599	0.003008127	1.196715629	up	0.002164502	--	--	--	--	--	--	--	--
pos_356	Patulin	2.38E-05	2.00E-05	5.20E-05	3.67E-05	3.62E-05	3.65E-05	7.14E-05	9.83E-05	7.14E-05	7.32E-05	6.03E-05	3.90E-05	3.42E-05	6.89E-05	2.02	1.010922623	0.005142749	1.184063753	up	0.008127043	--	--	--	--	--	--	--	--
pos_360	Debneyol	0.000854228	0.000300815	0.000271237	0.000267617	0.000543212	0.00039861	0.000151078	9.35E-05	0.00013745	0.000138746	0.000180203	0.000220029	0.000439287	0.000153508	0.35	-1.516847607	0.027371157	1.066463376	down	0.002164502	--	--	--	--	--	--	--	--
pos_361	3-propyl acrolein	4.28E-06	2.05E-06	1.06E-06	1.91E-07	2.67E-06	1.56E-06	9.22E-06	1.12E-05	4.98E-06	5.08E-06	6.43E-06	1.21E-05	1.97E-06	8.16E-06	4.14	2.050270115	0.002989401	1.206826461	up	0.002164502	--	--	--	--	--	--	--	--
pos_362	Carvyl propionate	3.08E-05	1.03E-05	3.97E-05	1.28E-05	5.16E-05	4.68E-05	0.000233236	0.000298625	0.000185908	0.000131076	0.000225562	0.000155956	3.20E-05	0.000205061	6.41	2.680208635	0.000586222	1.355780098	up	0.002164502	--	--	--	--	--	--	--	--
pos_364	3-(Carboxymethylamino)propanoic acid	8.65E-06	1.03E-05	1.22E-05	1.11E-05	1.28E-05	1.14E-05	1.55E-05	1.53E-05	1.46E-05	1.49E-05	1.39E-05	1.39E-05	1.11E-05	1.47E-05	1.32	0.405700158	0.000981134	1.314086059	up	0.004998125	--	--	--	--	--	--	--	--
pos_365	"8-Deoxy-11,13-dihydroxygrosheimin"	8.39E-05	8.95E-05	9.07E-05	9.66E-05	8.06E-05	8.97E-05	0.000142205	0.000116485	0.000125343	0.000138273	8.99E-05	0.000135674	8.85E-05	0.000124653	1.41	0.494018475	0.005020345	1.228091259	up	0.008658009	--	--	--	--	--	--	--	--
pos_366	(±)-Anisoxide	2.79E-05	3.07E-05	3.47E-05	3.39E-05	3.91E-05	3.26E-05	6.11E-05	5.43E-05	4.72E-05	4.76E-05	4.74E-05	5.35E-05	3.31E-05	5.19E-05	1.57	0.64682738	8.42E-05	1.36893274	up	0.002164502	--	--	--	--	--	--	--	--
pos_367	"4,4alpha,5,6-Tetrahydro-7-methyl-2(3H)-naphthalenone"	1.17E-06	1.08E-05	6.27E-06	1.15E-05	4.42E-06	4.70E-06	4.34E-05	3.61E-05	3.45E-05	4.47E-05	5.06E-05	8.42E-05	6.47E-06	4.89E-05	7.56	2.91756059	0.001932425	1.26733342	up	0.002164502	--	--	--	--	--	--	--	--
pos_372	Ala Trp Leu Ile	0.000122255	0.000106706	8.96E-05	7.90E-05	4.34E-05	2.97E-05	3.34E-05	2.26E-05	2.72E-05	1.39E-05	7.66E-06	7.47E-06	7.85E-05	1.87E-05	0.24	-2.067395765	0.008248124	1.157327518	down	0.004329004	--	--	--	--	--	--	--	--
pos_374	"1',2'-Dihydro-1',2'-dihydroxy-4-ketotoruelene/ (4-Ketophleixanthophyll)"	0	0	3.79E-06	0	5.80E-07	0	5.77E-05	0.000233274	9.37E-05	5.65E-05	4.73E-05	0.00010484	7.29E-07	9.89E-05	135.64	7.083612371	0.018218796	1.129691323	up	0.004336913	--	--	--	--	--	--	--	--
pos_379	2-Protocatechoylphloroglucinolcarboxylate	0.000193053	0.000145629	0.000117133	0.000145342	0.000218063	0.00018754	0.000339258	0.000374897	0.000339751	0.000395686	0.000430164	0.000434078	0.000167794	0.000385639	2.3	1.200562979	2.87E-06	1.373110071	up	0.002164502	Depsides and depsidones	--	--	HMDB0059651	440370	--	Phenylpropanoids and polyketides	--
pos_382	9(R)-HODE	0	0	0	0	0	0	1.47E-05	1.00E-05	1.46E-05	1.40E-05	1.13E-05	1.70E-05	0	1.36E-05	Inf	Inf	4.53E-05	1.430353331	up	0.00277843	--	--	--	--	--	--	--	--
pos_383	"5,6,7,8-Tetrahydro-2,4-dimethylquinoline"	1.66E-05	1.57E-05	1.78E-05	2.02E-05	1.85E-05	1.99E-05	2.95E-05	2.37E-05	2.89E-05	2.71E-05	1.96E-05	2.62E-05	1.81E-05	2.58E-05	1.42	0.510330231	0.002364646	1.252583909	up	0.008658009	--	--	--	--	--	--	--	--
pos_385	Exemestane	0.000161759	0.000162269	0.000160491	0.000168693	0.000172269	0.000173965	0.000260382	0.000226028	0.000226046	0.000208836	0.000191039	0.000227915	0.000166574	0.000223374	1.34	0.423297956	0.001375091	1.333780887	up	0.002164502	--	--	--	--	--	--	--	--
pos_386	Asn Pro Tyr	3.33E-05	1.76E-05	4.37E-05	2.14E-05	2.72E-05	2.83E-05	1.60E-06	9.86E-06	7.66E-06	1.28E-06	1.42E-06	1.18E-06	2.86E-05	3.83E-06	0.13	-2.897811297	0.000588694	1.290035233	down	0.002164502	--	--	--	--	--	--	--	--
pos_390	Quinone	1.14E-05	1.12E-05	7.74E-06	8.52E-06	1.28E-05	1.16E-05	1.38E-05	2.98E-05	4.84E-05	1.51E-05	4.25E-05	3.50E-05	1.05E-05	3.08E-05	2.92	1.546223849	0.016733014	1.065899307	up	0.002164502	--	--	--	--	--	--	--	--
pos_391	"6-Methyl-3,5-heptadien-2-one"	8.76E-06	8.75E-06	2.03E-06	1.03E-05	5.47E-06	7.51E-06	0	0	0	6.05E-07	0	0	7.13E-06	1.01E-07	0.01	-6.144601344	0.002087698	1.304503268	down	0.003664548	--	--	--	--	--	--	--	--
pos_392	3-Methylcrotonaldehyde	1.53E-06	7.15E-07	7.88E-07	6.12E-07	2.19E-06	1.57E-06	2.13E-06	2.08E-06	2.97E-06	3.31E-06	4.64E-06	2.33E-06	1.23E-06	2.91E-06	2.36	1.236120395	0.006973709	1.039343097	up	0.008658009	Organooxygen compounds	--	--	HMDB0012157	61020	107-86-8	Organic oxygen compounds	Carbonyl compounds
pos_394	Ala Phe Lys Lys	2.94E-05	1.19E-05	8.70E-06	9.18E-06	5.01E-06	1.22E-06	0.000809315	0.001056548	0.00059931	6.50E-05	0.000112732	0.000179578	1.09E-05	0.000470417	43.18	5.432415524	0.041419221	1.027616598	up	0.002164502	--	--	--	--	--	--	--	--
pos_395	"1,25-Dihydroxyvitamin D3 3-glycoside"	0.000320371	0.000218138	6.06E-05	0.000233325	0.000233953	0.000343006	0.001522952	0.001629258	0.000877627	0.000899989	0.000480615	0.00100123	0.000234892	0.001068612	4.55	2.185666077	0.00454306	1.259383487	up	0.002164502	--	--	--	--	--	--	--	--
pos_396	His Lys Met	0.000140044	0.00015272	0.000101086	0.000146941	9.35E-05	9.38E-05	0.000344016	0.000407766	0.000261635	0.000399222	0.000184175	0.000315735	0.000121344	0.000318758	2.63	1.393363182	0.001631777	1.294728982	up	0.002164502	--	--	--	--	--	--	--	--
pos_397	Eruberin C	0.001025718	0.001016256	0.000585607	0.000770785	0.000726586	0.000802753	0.002015649	0.001127848	0.001003661	0.001619272	0.001357983	0.001769072	0.000821284	0.001482248	1.8	0.851832817	0.006852555	1.114229664	up	0.008658009	--	--	--	--	--	--	--	--
pos_398	Eremopetasinorol	1.32E-05	9.46E-06	1.96E-05	1.12E-05	2.72E-05	2.69E-05	0.000135296	0.000152712	0.000114684	0.000102797	0.000169202	0.000104343	1.79E-05	0.000129839	7.24	2.85593042	8.37E-05	1.400264004	up	0.002164502	--	--	--	--	--	--	--	--
pos_399	"1,4,5-Naphthalenetriol"	0.000654364	0.000445836	0.000757357	0.000607617	0.000790363	0.00058598	0.000126046	0.000138464	0.000143787	0.000123408	0.000122454	0.0001357	0.000640253	0.000131643	0.21	-2.282009499	0.000166802	1.397061439	down	0.002164502	--	--	--	--	--	--	--	--
pos_401	"2',4'-Dihydroxy-2''-(1-hydroxy-1-methylethyl)dihydrofuro[2,3-h]flavanone"	0.000461555	0.000257272	0.00034069	0.000197595	0.000263352	0.000309745	0.000583532	0.000583511	0.000836942	0.000426914	0.000650538	0.000826332	0.000305035	0.000651295	2.14	1.094336482	0.00164004	1.204864596	up	0.004329004	--	--	--	--	--	--	--	--
pos_402	Castillene D	2.35E-05	2.08E-05	2.76E-05	2.23E-05	2.26E-05	2.12E-05	1.66E-05	1.50E-05	1.25E-05	1.41E-05	9.99E-06	1.65E-05	2.30E-05	1.41E-05	0.61	-0.706768611	0.000102355	1.284432426	down	0.002164502	--	--	--	--	--	--	--	--
pos_403	Conhydrinone	4.56E-06	5.87E-06	4.80E-06	5.88E-06	4.61E-06	8.92E-06	1.60E-05	8.77E-06	1.46E-05	9.14E-06	1.42E-05	8.83E-06	5.77E-06	1.19E-05	2.07	1.047520206	0.004638766	1.162894449	up	0.008658009	--	--	--	--	--	--	--	--
pos_404	Cerulenin	8.23E-06	5.45E-06	5.88E-06	6.80E-06	7.35E-06	6.73E-06	8.07E-06	7.72E-06	8.18E-06	9.60E-06	8.08E-06	9.09E-06	6.74E-06	8.46E-06	1.25	0.326765952	0.007700278	1.043730884	up	0.025974026	--	--	--	--	--	--	--	--
pos_405	"5,6-Dihydro-4-methoxy-6-[2-(4-methoxyphenyl)ethyl]-2H-pyran-2-one"	7.57E-06	5.56E-06	1.09E-05	1.54E-05	1.02E-05	1.24E-05	3.34E-05	2.55E-05	2.83E-05	3.01E-05	2.14E-05	3.30E-05	1.03E-05	2.86E-05	2.77	1.468634399	2.40E-05	1.389657187	up	0.002164502	--	--	--	--	--	--	--	--
pos_406	Thymol	3.91E-05	2.02E-05	2.58E-05	2.66E-05	4.05E-05	3.93E-05	1.49E-05	1.64E-05	1.31E-05	3.20E-05	4.43E-06	1.18E-05	3.20E-05	1.54E-05	0.48	-1.048498205	0.009536207	1.047904176	down	0.015151515	--	--	--	--	--	--	--	--
pos_410	5-Tridecynoic acid	0.000228043	0.000240485	0.000217436	0.000291788	0.000278379	0.000457603	0.000585977	0.000504175	0.001050281	0.000734249	0.000662729	0.001095294	0.000285622	0.000772117	2.7	1.434711594	0.00341151	1.202762127	up	0.002164502	--	--	--	--	--	--	--	--
pos_411	N2-(3-Carboxy-2-hydroxy-1-oxopropyl)arginine	0.005870162	0.006270965	0.000540447	0.001931017	0.004153338	0.004020909	0.000232569	0.000233441	0.000425585	0.000257852	0.00022309	0.001165791	0.003797806	0.000423055	0.11	-3.16624995	0.013121487	1.160805964	down	0.004329004	--	--	--	--	--	--	--	--
pos_413	Lys Lys Val His	2.53E-05	1.82E-05	2.72E-05	3.66E-05	3.18E-05	4.53E-05	8.16E-05	7.88E-05	0.00012164	8.09E-05	6.94E-05	8.61E-05	3.07E-05	8.64E-05	2.81	1.490754245	0.000206237	1.349677395	up	0.002164502	--	--	--	--	--	--	--	--
pos_415	"2,3-dinor Fluprostenol"	3.26E-05	5.47E-06	2.52E-05	4.06E-06	2.36E-05	2.25E-05	0	1.39E-06	0	0	0	8.95E-07	1.89E-05	3.81E-07	0.02	-5.630808429	0.010878758	1.162733914	down	0.004336913	--	--	--	--	--	--	--	--
pos_421	"Methyl (2E,6Z)-dodecadienoate"	0.000494947	0.000484869	0.000526678	0.000571637	0.000616268	0.000920116	0.00112188	0.000975412	0.001914257	0.00123408	0.00118451	0.00181745	0.000602419	0.001374598	2.28	1.190170307	0.003289544	1.200081939	up	0.002164502	--	--	--	--	--	--	--	--
pos_429	Asp Asp Asp	0.006447369	0.003215749	0.00230125	0.003061992	0.005836029	0.004850166	0.008746194	0.014251226	0.005473377	0.011287628	0.008652694	0.004968579	0.004285426	0.008896616	2.08	1.053818135	0.022274051	1.00090347	up	0.025974026	--	--	--	--	--	--	--	--
pos_431	"Biphenyl-2,3-diol"	0.00045686	0.000238151	0.000537764	0.000355001	0.000618474	0.000490099	0.00016375	0.000256146	0.000218014	0.000242795	0.000225739	0.00022768	0.000449392	0.000222354	0.49	-1.015113969	0.00835909	1.148862959	down	0.008658009	--	C02526	Metabolic pathways(ko01100)	--	--	--	--	--
pos_436	PG(13:0/12:0)	0.000279658	0.000255973	0.000294068	0.000346677	0.000346816	0.000417493	0.0006695	0.000553066	0.000588557	0.000577851	0.000435868	0.000551348	0.000323448	0.000562698	1.74	0.798829832	0.000144878	1.345465064	up	0.002164502	--	--	--	--	--	--	--	--
pos_438	4-oxo-2-Nonenal	4.54E-05	2.59E-05	2.01E-05	2.56E-05	3.25E-05	3.10E-05	7.32E-05	7.45E-05	5.11E-05	8.35E-05	8.98E-05	0.000109261	3.01E-05	8.02E-05	2.67	1.415419943	0.000698487	1.261158626	up	0.002164502	Organooxygen compounds	--	--	HMDB0060285	6445537	--	Organic oxygen compounds	Carbonyl compounds
pos_441	Leupeptin	1.93E-05	2.06E-05	2.29E-05	2.67E-05	2.44E-05	3.18E-05	5.95E-05	6.25E-05	7.06E-05	4.44E-05	3.72E-05	5.77E-05	2.43E-05	5.53E-05	2.28	1.187195996	0.000939012	1.337154066	up	0.002164502	--	--	--	--	--	--	--	--
pos_442	Capsi-amide	0.000426981	0.00043529	0.000452177	0.000534666	0.000558333	0.000684829	0.000944551	0.000843006	0.000958907	0.000831607	0.000757167	0.000975767	0.000515379	0.000885167	1.72	0.780315211	4.80E-05	1.362805816	up	0.002164502	Carboxylic acids and derivatives	--	--	HMDB0040940	47346	64317-66-4	Organic acids and derivatives	Carboxylic acid derivatives
pos_443	4-Biphenylamine	9.78E-06	9.97E-06	8.65E-06	1.04E-05	1.09E-05	1.25E-05	1.49E-05	1.32E-05	1.52E-05	1.44E-05	1.09E-05	1.25E-05	1.04E-05	1.35E-05	1.31	0.385613849	0.004424228	1.155387629	up	0.012748797	Benzene and substituted derivatives	--	--	HMDB0013195	7102	92-67-1	Benzenoids	Biphenyls and derivatives
pos_445	Protoanemonin	8.75E-05	7.66E-05	0.000149091	0.000120376	0.000119358	0.00012042	0.000207451	0.000260701	0.000196394	0.00018872	0.000172697	0.000117804	0.000112229	0.000190628	1.7	0.764312736	0.007244243	1.162288575	up	0.025974026	--	--	--	--	--	--	--	--
pos_448	(¡À)9-HpODE	7.55E-05	7.38E-05	7.68E-06	4.88E-05	5.14E-05	6.49E-05	2.42E-05	1.97E-05	1.62E-05	1.55E-05	3.91E-06	2.87E-05	5.37E-05	1.80E-05	0.34	-1.572056712	0.016055831	1.084020714	down	0.041125541	--	--	--	--	--	--	--	--
pos_449	4-Dodecylphenol	0.000316559	0.000418321	0.000288119	0.000439577	0.000314008	0.000683176	0.0009828	0.000631947	0.001405323	0.000739005	0.001202616	0.000800264	0.00040996	0.000960326	2.34	1.228041333	0.004305652	1.15296978	up	0.004329004	--	--	--	--	--	--	--	--
pos_450	Isomytiloxanthin	1.02E-05	8.22E-05	1.86E-06	6.07E-05	5.12E-06	5.35E-05	0.000218922	0.00016857	8.98E-05	0.000198457	8.95E-05	0.000212372	3.56E-05	0.00016294	4.57	2.193764123	0.001871928	1.229833663	up	0.002164502	--	--	--	--	--	--	--	--
pos_453	"Mesquitol-4beta-ol 3,8-dimethyl ether"	6.93E-06	0	9.15E-06	0	0	0	4.45E-05	8.03E-05	3.04E-05	5.40E-05	2.90E-05	4.99E-06	2.68E-06	4.05E-05	15.13	3.919665318	0.014574993	1.136128061	up	0.011518904	--	--	--	--	--	--	--	--
pos_454	His Met Met Glu	0.004992889	0.005315786	0.003181561	0.006762052	0.0042683	0.005054424	0.001199825	0.001326373	0.002062078	0.001154603	0.001629963	0.000922725	0.004929168	0.001382594	0.28	-1.833966255	0.000397713	1.34078936	down	0.002164502	--	--	--	--	--	--	--	--
pos_457	pentanamide	2.97E-05	2.84E-05	3.05E-05	3.80E-05	3.22E-05	3.56E-05	5.23E-05	4.34E-05	4.32E-05	4.41E-05	3.59E-05	4.78E-05	3.24E-05	4.45E-05	1.37	0.456197017	0.001604528	1.250345322	up	0.004329004	--	--	--	--	--	--	--	--
pos_458	O-BENZYL-l-SERINE	8.93E-06	1.40E-05	1.04E-05	1.68E-05	1.59E-05	2.00E-05	3.23E-05	2.60E-05	3.01E-05	3.49E-05	3.00E-05	4.03E-05	1.43E-05	3.23E-05	2.25	1.172504473	5.17E-05	1.337010493	up	0.002164502	--	--	--	--	--	--	--	--
pos_459	"3,3-Difluoro-17-methyl-5alpha-androstan-17beta-ol"	0.000100698	9.28E-05	0.000116573	0.000131938	0.000128022	0.000140095	0.000219777	0.000190339	0.000194445	0.000172845	0.000163297	0.00020715	0.00011836	0.000191309	1.62	0.692727524	8.53E-05	1.359080785	up	0.002164502	--	--	--	--	--	--	--	--
pos_461	Coniine	3.17E-05	2.83E-05	3.29E-05	3.75E-05	3.41E-05	3.81E-05	5.68E-05	4.65E-05	5.06E-05	4.81E-05	4.50E-05	5.35E-05	3.38E-05	5.01E-05	1.48	0.568603985	4.85E-05	1.366531225	up	0.002164502	--	--	--	HMDB0030285	9985	458-88-8	Alkaloids and derivatives	--
pos_464	12-Dihydrodalbinol	2.27E-05	4.95E-07	8.08E-06	7.96E-07	1.53E-05	1.31E-05	0	2.79E-07	6.12E-07	0	0	0	1.01E-05	1.48E-07	0.01	-6.087207477	0.038054822	1.005226748	down	0.007154777	--	--	--	--	--	--	--	--
pos_465	Methyl 5-hydroxyoxindole-3-acetate	3.30E-05	6.70E-05	3.18E-05	7.24E-05	3.76E-05	5.44E-05	0.000193214	7.71E-05	9.87E-05	0.000122569	9.90E-05	0.000166279	4.94E-05	0.000126161	2.56	1.35337268	0.006687554	1.155052016	up	0.002164502	--	--	--	--	--	--	--	--
pos_466	Corey PG-Lactone Diol	0	0	0	0	0	0	2.86E-05	5.05E-05	2.34E-05	1.58E-06	6.92E-06	9.40E-06	0	2.01E-05	Inf	Inf	0.042092584	1.023140177	up	0.00277843	--	--	--	--	--	--	--	--
pos_471	Succinic anhydride	6.16E-07	2.22E-06	4.12E-07	8.98E-07	2.42E-06	3.26E-06	4.45E-06	3.30E-06	8.97E-06	7.29E-06	4.97E-06	7.89E-06	1.64E-06	6.14E-06	3.75	1.907608093	0.00262462	1.180866674	up	0.002164502	--	--	--	--	--	--	--	--
pos_473	"2,2,4-Trimethyl-3-(4-fluorophenyl)-2H-1-benzopyran-7-ol acetate"	0.000358532	0.000336297	0.00023639	0.000333674	0.000324718	0.000323747	8.00E-05	7.00E-05	6.24E-05	6.88E-05	0.000100907	8.30E-05	0.000318893	7.75E-05	0.24	-2.040575403	1.06E-05	1.447645339	down	0.002164502	--	--	--	--	--	--	--	--
pos_475	Propyl levulinate	0.00136844	0.000973904	0.000694966	0.00089944	0.001330882	0.001096682	0.00022514	0.000344488	0.000368453	0.000352863	0.000372738	0.000530253	0.001060719	0.000365656	0.34	-1.536484212	0.000671456	1.339295634	down	0.002164502	--	--	--	--	--	--	--	--
pos_480	"2,5-Dimethoxycinnamic acid"	8.68E-05	7.28E-05	6.77E-05	6.06E-05	8.60E-05	8.45E-05	2.91E-05	3.84E-05	3.66E-05	4.20E-05	3.25E-05	4.60E-05	7.64E-05	3.74E-05	0.49	-1.028766099	7.12E-05	1.377038167	down	0.002164502	--	--	--	--	--	--	--	--
pos_482	Chromone	0.000292558	0.00028311	0.000227903	0.000244915	0.000338719	0.000294922	0.000373857	0.000470419	0.000433296	0.000506496	0.000481875	0.000401083	0.000280355	0.000444504	1.59	0.6649447	0.00012307	1.287670435	up	0.002164502	--	--	--	--	--	--	--	--
pos_485	"DL-3,4-Dihydroxyphenyl glycol"	3.01E-05	3.64E-05	2.47E-05	2.51E-05	1.76E-05	1.63E-05	6.38E-05	9.65E-05	5.91E-05	4.08E-05	6.91E-05	7.97E-05	2.50E-05	6.82E-05	2.72	1.44558619	0.0015554	1.269927587	up	0.002164502	--	--	--	--	--	--	--	--
pos_486	Armillaripin	0.003461658	0.004187179	0.003052773	0.004211581	0.002963545	0.003713495	0.006112502	0.005784733	0.004574682	0.006168973	0.003785765	0.00573964	0.003598372	0.005361049	1.49	0.575171077	0.004640554	1.176162052	up	0.008658009	Prenol lipids	--	--	HMDB0030404	21124297	129741-56-6	Lipids and lipid-like molecules	Sesquiterpenoids
pos_487	Cer(d16:1(4E)/18:1(9Z)(2OH))	0.001350045	0.00117525	0.00118152	0.001731888	0.001518487	0.002232941	0.002338174	0.001840383	0.002616436	0.002904409	0.001955671	0.003718818	0.001531688	0.002562315	1.67	0.742325082	0.013499181	1.039814438	up	0.008658009	--	--	--	--	--	--	--	--
pos_488	5-(hydroxymethyl)- 2-Furancarboxylic acid	0.000189674	0.000137764	0.000103204	0.000131037	0.000185605	0.000221661	0.000205543	0.000223279	0.000250595	0.000316337	0.00025394	0.000284702	0.000161491	0.000255733	1.58	0.663184822	0.003282337	1.099708627	up	0.004329004	--	--	--	--	--	--	--	--
pos_489	Anhalonidine	0.000169567	0.000150891	0.000110726	0.000114025	0.000199571	0.000176122	0.000397073	0.000304174	0.00030725	0.000207222	0.000348855	0.000508081	0.000153483	0.000345443	2.25	1.170363387	0.004321505	1.187681967	up	0.002164502	--	--	--	--	--	--	--	--
pos_491	"4-Methylheptane-3,5-dione"	3.68E-05	1.67E-05	1.88E-05	1.85E-05	3.04E-05	1.98E-05	3.83E-06	5.62E-07	3.15E-06	2.83E-06	3.77E-06	4.59E-06	2.35E-05	3.12E-06	0.13	-2.913213683	0.001443639	1.334066819	down	0.002164502	--	--	--	--	--	--	--	--
pos_493	2-O-methyl PAF C-16	8.78E-06	7.25E-06	8.95E-06	9.28E-06	7.99E-06	9.34E-06	2.06E-05	2.28E-05	2.51E-05	1.38E-05	1.54E-05	2.78E-05	8.60E-06	2.09E-05	2.43	1.282942984	0.002452382	1.301478106	up	0.002164502	--	--	--	--	--	--	--	--
pos_495	5-Hydroxymethyl-2-furaldehyde	0.000262899	0.000247288	0.000261998	0.000307163	0.00030353	0.000324208	0.000411285	0.0003793	0.000424941	0.000444973	0.000421633	0.000415206	0.000284514	0.000416223	1.46	0.548855085	1.39E-05	1.380284825	up	0.002164502	Organooxygen compounds	--	--	HMDB0034355	237332	67-47-0	Organic oxygen compounds	Carbonyl compounds
pos_496	Morpholine	0.000563286	0.000507867	0.000590877	0.00063795	0.000643689	0.000705709	0.001039695	0.000916092	0.000924851	0.000925479	0.000773906	0.001052356	0.00060823	0.00093873	1.54	0.626093569	0.000107087	1.3587316	up	0.002164502	--	--	--	--	--	--	--	--
pos_497	"3β-ACETOXYDEOXYANGOLENSIC ACID, METHYL ESTER"	1.84E-05	8.56E-06	9.44E-06	3.69E-05	6.77E-05	5.85E-05	0.000102634	8.20E-05	7.97E-05	0.000113443	0.000115171	0.000182038	3.32E-05	0.000112492	3.38	1.758504104	0.0020791	1.173972702	up	0.002164502	--	--	--	--	--	--	--	--
pos_498	LASALOCID	5.76E-05	2.26E-05	2.37E-05	4.04E-05	4.69E-05	4.45E-05	0.000170428	0.00013346	0.000117894	7.62E-05	6.83E-05	0.000129589	3.93E-05	0.000115985	2.95	1.561928643	0.003214656	1.252549102	up	0.002164502	--	--	--	--	--	--	--	--
pos_499	Phe Tyr Lys Lys	2.52E-06	0	0	1.38E-06	9.01E-07	2.30E-06	4.17E-05	5.31E-05	2.68E-05	1.12E-05	1.39E-05	3.95E-05	1.18E-06	3.10E-05	26.21	4.712045882	0.006882163	1.243045096	up	0.004998125	--	--	--	--	--	--	--	--
pos_500	Oxindole	1.18E-05	1.19E-05	1.17E-05	1.24E-05	1.35E-05	1.53E-05	2.54E-05	1.92E-05	2.13E-05	1.83E-05	1.69E-05	2.26E-05	1.28E-05	2.06E-05	1.61	0.688103249	0.000875961	1.30939208	up	0.002164502	Indoles and derivatives	C12312	Biosynthesis of secondary metabolites(ko01110);;Benzoxazinoid biosynthesis(ko00402)	HMDB0061918	321710	59-48-3	Organoheterocyclic compounds	Indolines
pos_501	"(6E,8E)-4,6,8-Megastigmatriene"	1.36E-05	1.28E-05	1.54E-05	1.63E-05	1.74E-05	1.69E-05	2.67E-05	2.49E-05	2.52E-05	2.26E-05	2.23E-05	2.83E-05	1.54E-05	2.50E-05	1.62	0.699797645	1.59E-05	1.395668532	up	0.002164502	--	--	--	--	--	--	--	--
pos_503	5-HYDROXYIMINOISOCARYOPHYLLENE	8.19E-06	7.96E-06	8.82E-06	8.22E-06	9.00E-06	9.43E-06	1.63E-05	1.43E-05	1.54E-05	1.14E-05	1.21E-05	1.41E-05	8.60E-06	1.39E-05	1.62	0.694026558	0.000573572	1.365117608	up	0.002164502	--	--	--	--	--	--	--	--
pos_504	Methyl rosmarinate	0.0009102	0.000370825	0.001257424	0.000427885	0.001198135	0.000922945	0.000135809	0.000248681	0.000236369	9.66E-05	8.55E-05	0.000189819	0.000847902	0.000165472	0.2	-2.357306525	0.006120829	1.182231131	down	0.002164502	Cinnamic acids and derivatives	--	--	HMDB0035446	6479915	99353-00-1	Phenylpropanoids and polyketides	Hydroxycinnamic acids and derivatives
pos_509	Epomediol	0.000160701	8.77E-05	0.000129014	0.00011616	0.00019467	0.000187098	4.05E-05	4.67E-05	5.94E-05	5.03E-05	4.17E-05	7.51E-05	0.000145893	5.23E-05	0.36	-1.480479321	0.002048956	1.261137677	down	0.002164502	--	--	--	--	--	--	--	--
pos_511	"6,10-Dimethyl-5(E),9-undecadien-2-one"	0	0	0	0	0	0	0.00017371	0.000148456	6.29E-05	7.34E-05	3.57E-05	0.000147065	0	0.000106875	Inf	Inf	0.00564406	1.257934785	up	0.00277843	--	--	--	--	--	--	--	--
pos_512	Boschniakine	6.31E-06	5.03E-06	6.62E-06	6.71E-06	7.85E-06	8.07E-06	1.25E-05	9.59E-06	1.32E-05	8.34E-06	7.80E-06	1.07E-05	6.77E-06	1.04E-05	1.53	0.614170906	0.008235463	1.146963189	up	0.008658009	Pyridines and derivatives	--	--	HMDB0030267	3530565	18070-40-1	Organoheterocyclic compounds	Pyridine carboxaldehydes
pos_514	Hydroxytyrosol 1-O-glucoside	0.004041399	0.003778521	0.003557821	0.003897572	0.00534372	0.00427469	0.00116395	0.001469512	0.001866691	0.002306874	0.001795864	0.002190971	0.004148954	0.001798977	0.43	-1.20557091	4.07E-05	1.374121917	down	0.002164502	--	--	--	--	--	--	--	--
pos_516	2-dodecenal	7.18E-06	5.57E-06	5.79E-06	7.90E-06	6.20E-06	8.49E-06	1.43E-05	1.24E-05	1.33E-05	1.21E-05	1.14E-05	1.23E-05	6.85E-06	1.26E-05	1.84	0.879809794	4.92E-06	1.409042802	up	0.002164502	--	--	--	--	--	--	--	--
pos_517	Etomidate	0.000247788	0.000223146	0.000271521	0.000307733	0.000303831	0.000357017	0.000520129	0.000452019	0.000463227	0.000447549	0.000369398	0.000514678	0.000285173	0.000461167	1.62	0.693451526	0.000157439	1.335939392	up	0.002164502	--	--	--	--	--	--	--	--
pos_518	C17 Sphinganine	0.000135485	0.000113669	0.000110288	0.000121996	0.000135292	0.000132792	0.000235078	0.000219785	0.000524629	0.000465254	0.000360323	0.000442476	0.00012492	0.000374591	3	1.584306414	0.004492816	1.205203212	up	0.002164502	--	--	--	--	--	--	--	--
pos_520	Isoamyl 2-furonpropionate	0	0	5.78E-05	9.26E-06	0	0	6.89E-05	0.000211799	7.61E-05	7.05E-05	5.99E-05	2.64E-05	1.12E-05	8.56E-05	7.66	2.936797565	0.03559342	1.004049741	up	0.007154777	--	--	--	--	--	--	--	--
pos_524	Benzene	5.46E-05	3.92E-05	3.98E-05	4.39E-05	6.52E-05	5.63E-05	7.15E-05	7.60E-05	5.78E-05	8.64E-05	6.58E-05	7.92E-05	4.99E-05	7.28E-05	1.46	0.54536502	0.003203394	1.129676381	up	0.004329004	Benzene and substituted derivatives	C01407	Metabolic pathways(ko01100)	HMDB0001505	241	71-43-2	Benzenoids	--
pos_526	4-Tridecynoic acid	0.000520345	0.000549222	0.000488681	0.000546877	0.00051889	0.000677887	0.001084946	0.000999986	0.001248522	0.000972312	0.000943917	0.001338323	0.000550317	0.001098001	2	0.996544552	0.000151211	1.370984204	up	0.002164502	--	--	--	--	--	--	--	--
pos_529	Anapear	3.12E-05	5.38E-06	4.67E-06	4.12E-06	1.62E-05	1.17E-05	5.83E-05	6.33E-05	3.98E-05	8.18E-05	7.88E-05	6.24E-05	1.22E-05	6.41E-05	5.25	2.391759458	7.81E-05	1.305234505	up	0.002164502	--	--	--	--	--	--	--	--
pos_530	Phosphatidyl glycerol	7.22E-05	9.89E-05	5.22E-05	0.000112185	0.000101175	0.000100094	0.000469613	0.000256576	0.000470313	0.000174992	0.000292479	0.00071189	8.95E-05	0.000395977	4.43	2.145990593	0.011664944	1.143278893	up	0.002164502	--	--	--	--	--	--	--	--
pos_532	Sodium dehydroacetate	9.06E-06	8.52E-06	1.10E-05	9.60E-06	1.10E-05	9.55E-06	1.64E-05	1.36E-05	1.87E-05	1.28E-05	1.14E-05	1.29E-05	9.79E-06	1.43E-05	1.46	0.547686597	0.008017469	1.173428791	up	0.004998125	Organooxygen compounds	--	--	HMDB0033129	54678494	771-03-9	Organic oxygen compounds	Carbonyl compounds
pos_534	Longifolenaldehyde	1.83E-05	7.27E-06	5.31E-06	5.83E-06	8.99E-06	1.15E-05	2.43E-06	2.60E-07	2.54E-06	2.24E-06	1.85E-06	8.33E-06	9.53E-06	2.94E-06	0.31	-1.696477123	0.020133065	1.039841629	down	0.015151515	--	--	--	--	--	--	--	--
pos_536	PC(16:0/9:0(CHO))	0.000724015	0.000395966	0.000727192	0.00046736	0.000590437	0.000571945	0.000462516	0.000421333	0.000241338	0.000266825	0.000182017	0.000210029	0.000579486	0.000297343	0.51	-0.962646063	0.00305314	1.114666248	down	0.008658009	--	--	--	--	--	--	--	--
pos_537	"1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 / 1α,25-dihydroxy-2β-(3-hydroxypropoxy)cholecalciferol"	5.87E-06	3.65E-06	3.55E-06	4.58E-06	8.56E-06	9.83E-06	2.21E-05	4.12E-05	1.67E-05	1.84E-05	9.14E-06	2.08E-05	6.01E-06	2.14E-05	3.56	1.833398006	0.015811275	1.133827093	up	0.004329004	--	--	--	--	--	--	--	--
pos_539	MILTEFOSINE	3.70E-05	3.56E-05	3.78E-05	5.41E-05	7.47E-05	0.000133278	0.000158715	0.000140289	0.00028335	0.000191087	0.000223655	0.000302862	6.21E-05	0.00021666	3.49	1.803326502	0.001094525	1.230624903	up	0.002164502	--	--	--	--	--	--	--	--
pos_540	Lys Leu Pro Arg	1.12E-06	1.05E-06	8.21E-07	3.44E-07	1.68E-06	6.05E-07	3.37E-05	2.35E-05	3.48E-05	1.25E-05	1.39E-05	6.99E-05	9.38E-07	3.14E-05	33.44	5.063438571	0.016634542	1.109604347	up	0.002164502	--	--	--	--	--	--	--	--
pos_541	Dehydrooreadone	1.73E-05	1.99E-05	1.80E-05	1.80E-05	1.78E-05	2.05E-05	4.43E-05	3.48E-05	3.40E-05	3.15E-05	2.82E-05	3.90E-05	1.86E-05	3.53E-05	1.9	0.925487523	0.000594786	1.369822262	up	0.004998125	--	--	--	--	--	--	--	--
pos_542	JUGLONE	1.99E-05	1.69E-05	4.21E-05	2.18E-05	2.83E-05	1.98E-05	0	0	1.73E-06	0	0	0	2.48E-05	2.89E-07	0.01	-6.42288993	0.001270868	1.305816456	down	0.003664548	--	--	--	--	--	--	--	--
pos_543	Gly Phe Asn His	0.000481531	0.000753864	0.000621642	0.00058851	0.000354016	0.00016616	0.00015832	3.00E-05	5.41E-05	2.07E-06	2.44E-05	1.62E-05	0.000494287	4.75E-05	0.1	-3.378598116	0.002701897	1.245536234	down	0.002164502	--	--	--	--	--	--	--	--
pos_544	1-Oxo-1H-2-benzopyran-3-carboxaldehyde	9.15E-06	1.45E-05	1.59E-05	1.94E-05	1.40E-05	1.91E-05	0	8.25E-07	2.47E-08	0	0	0	1.53E-05	1.42E-07	0.01	-6.759081391	0.000169855	1.378961586	down	0.004336913	--	--	--	--	--	--	--	--
pos_545	4-Hydroxycoumarin	0.000817156	0.000585599	0.00140733	0.000557334	0.000835141	0.000469427	0.000322753	0.000381325	0.000384342	0.000226674	0.000331154	0.000378587	0.000778664	0.000337472	0.43	-1.206232153	0.024201956	1.022106535	down	0.002164502	Cinnamyl alcohols	C02646	Phenylpropanoid biosynthesis(ko00940);;Biosynthesis of secondary metabolites(ko01110);;Metabolic pathways(ko01100)	HMDB0003654	5280535	20649-40-5	Phenylpropanoids and polyketides	--
pos_547	"2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-diene-7,8-diol"	6.45E-06	3.38E-06	8.86E-06	2.10E-06	8.24E-06	1.25E-05	0.000107876	0.000212101	0.00010425	3.44E-05	0.000125766	0.00010631	6.92E-06	0.000115114	16.62	4.055232056	0.005542179	1.244763819	up	0.002164502	--	--	--	--	--	--	--	--
pos_548	Momorcharaside B	7.92E-05	8.75E-05	3.67E-05	7.25E-05	5.13E-05	7.20E-05	0.000418417	0.000429277	0.000243206	0.000277566	0.000199105	0.000406679	6.65E-05	0.000329042	4.94	2.305904923	0.001189961	1.343753168	up	0.002164502	Steroids and steroid derivatives	--	--	HMDB0032941	73744218	134886-64-9	Lipids and lipid-like molecules	Steroidal glycosides
pos_549	3-(4-Methylphenyl)oxiranecarboxylic acid	4.02E-05	3.83E-05	4.53E-05	6.23E-05	4.76E-05	8.06E-05	0.000142177	0.000106817	0.000234753	0.000116551	7.98E-05	0.000114805	5.24E-05	0.000132491	2.53	1.33903356	0.013450719	1.121495783	up	0.004329004	--	--	--	--	--	--	--	--
pos_550	DL-b-Hydroxycaprylic acid	0.000128723	4.68E-05	4.25E-05	4.39E-05	8.26E-05	5.84E-05	2.06E-05	1.46E-05	1.76E-05	1.79E-05	2.70E-05	2.72E-05	6.72E-05	2.08E-05	0.31	-1.689235926	0.019307755	1.116998603	down	0.002164502	--	--	--	--	--	--	--	--
pos_551	METHACHOLINE	0.000157116	0.000107801	5.66E-05	6.47E-05	0.000136305	0.000165722	2.95E-05	4.67E-05	4.52E-05	3.82E-05	6.29E-05	7.63E-05	0.000114702	4.98E-05	0.43	-1.204174823	0.0170234	1.091185846	down	0.015151515	--	--	--	--	--	--	--	--
pos_553	Cer(d18:0/16:0)	5.73E-05	0.000131859	5.25E-05	0.000164966	3.42E-05	0.00030149	0.000335195	0.000262549	0.00040073	0.000709507	0.000392415	0.000869734	0.000123713	0.000495022	4	2.000497583	0.010555318	1.075976234	up	0.004329004	Sphingolipids	--	--	HMDB0011760	5283572	5966-29-0	Lipids and lipid-like molecules	Ceramides
pos_556	Sebiferic acid	1.20E-05	6.66E-06	1.11E-05	1.05E-05	1.44E-05	1.32E-05	7.62E-05	0.000105771	7.96E-05	4.47E-05	6.11E-05	0.000124512	1.13E-05	8.20E-05	7.25	2.857659871	0.001855039	1.320300567	up	0.002164502	--	--	--	--	--	--	--	--
pos_557	"1,2,3-Trimethylbenzene"	0.000138267	6.04E-05	7.06E-05	5.86E-05	0.000124956	0.000124723	5.99E-06	1.33E-05	6.19E-06	1.25E-05	7.23E-06	2.10E-05	9.63E-05	1.10E-05	0.11	-3.125149354	0.002129633	1.300860558	down	0.002164502	--	--	--	--	--	--	--	--
pos_558	Mequinol	0	0	0	0	7.51E-07	0	1.56E-06	3.76E-06	2.07E-06	1.57E-06	3.19E-06	0	1.25E-07	2.02E-06	16.16	4.014766451	0.016524105	1.084869131	up	0.016711445	--	--	--	--	--	--	--	--
pos_560	4-Dimethylamino-L-phenylalanine	0.000215558	0.000164344	2.42E-05	8.47E-05	0.000118728	0.000115036	0.000283921	0.000199962	0.000194629	0.000393651	0.000405397	0.000476895	0.000120426	0.000325743	2.7	1.43558791	0.005837231	1.063689964	up	0.008658009	--	--	--	--	--	--	--	--
pos_563	Narcissin	0.002421239	0.005070231	0.001922235	0.007322927	0.003209308	0.006071494	0.000830007	0.00052294	0.001403142	0.001055963	0.001322184	0.001305418	0.004336239	0.001073276	0.25	-2.014423525	0.013354972	1.10102418	down	0.002164502	--	--	--	--	--	--	--	--
pos_564	"N2,N2-Dimethylguanosine"	0.000149986	7.10E-05	0.000166064	8.98E-05	0.000176576	0.000151259	5.14E-05	3.30E-05	4.82E-05	3.12E-05	4.09E-05	6.08E-05	0.000134123	4.43E-05	0.33	-1.599398012	0.003043246	1.237822994	down	0.002164502	Purine nucleosides	--	--	HMDB0004824	92919	2140-67-2	"Nucleosides, nucleotides, and analogues"	--
pos_565	Novobiocin	6.97E-06	1.74E-05	6.96E-06	1.47E-05	8.33E-06	9.04E-06	0	0	0	0	0	0	1.06E-05	0	0	#NAME?	0.002021173	1.295741657	down	0.00277843	Coumarins and derivatives	C05080	Biosynthesis of secondary metabolites(ko01110);;Metabolic pathways(ko01100)	HMDB0015185	54675769	303-81-1	Phenylpropanoids and polyketides	Coumarin glycosides
pos_566	"N,N-Dimethylsphingosine"	0.000324841	0.000285389	0.000354954	0.000357942	0.000313605	0.000372338	0.000485815	0.000442077	0.000493253	0.000442736	0.000364224	0.000500338	0.000334845	0.00045474	1.36	0.441549919	0.001072402	1.276359017	up	0.004329004	--	--	--	--	--	--	--	--
pos_570	Threoninyl-Methionine	0.000416775	0.000415887	0.000421521	0.000465853	0.000491263	0.000499261	0.000798779	0.000727348	0.000714848	0.000667221	0.00064222	0.00075458	0.00045176	0.000717499	1.59	0.667421103	6.80E-06	1.421967795	up	0.002164502	Carboxylic acids and derivatives	--	--	HMDB0029067	7020164	90729-28-5	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_572	L-erythro-tetrahydrobiopterin	5.36E-06	5.14E-06	6.45E-06	8.47E-06	7.09E-06	9.33E-06	1.06E-05	1.15E-05	1.29E-05	9.39E-06	1.08E-05	1.46E-05	6.97E-06	1.16E-05	1.67	0.73599383	0.001068571	1.237531156	up	0.002164502	Pteridines and derivatives	C00272	Folate biosynthesis(ko00790);;Metabolic pathways(ko01100)	HMDB0000027	44257	62989-33-7	Organoheterocyclic compounds	Pterins and derivatives
pos_573	Prolyl-Tryptophan	4.80E-07	9.12E-07	1.40E-06	0	3.47E-07	2.01E-06	3.58E-06	4.69E-06	2.68E-06	6.92E-06	2.85E-06	1.63E-06	8.57E-07	3.73E-06	4.35	2.120146867	0.011149759	1.102388875	up	0.004329004	--	--	--	--	--	--	--	--
pos_574	Isoleucyl-Arginine	3.02E-05	3.06E-05	2.82E-05	3.44E-05	4.18E-05	4.25E-05	6.57E-05	6.74E-05	6.17E-05	6.09E-05	6.74E-05	7.93E-05	3.46E-05	6.71E-05	1.94	0.954902417	5.29E-06	1.388554391	up	0.004998125	--	--	--	--	--	--	--	--
pos_575	Prolyl-Glutamate	1.46E-05	1.41E-05	1.34E-05	1.67E-05	1.51E-05	1.87E-05	2.86E-05	1.98E-05	1.92E-05	2.65E-05	2.23E-05	2.92E-05	1.54E-05	2.43E-05	1.57	0.654248577	0.002981185	1.204091323	up	0.002164502	--	--	--	--	--	--	--	--
pos_576	Isoleucyl-Glutamine	7.43E-06	7.96E-06	7.82E-06	8.12E-06	8.64E-06	9.85E-06	1.25E-05	1.16E-05	1.25E-05	9.93E-06	1.06E-05	1.36E-05	8.30E-06	1.18E-05	1.42	0.504631862	0.000566294	1.294226754	up	0.004998125	--	--	--	--	--	--	--	--
pos_578	Arginyl-Glutamine	2.83E-05	2.97E-05	2.49E-05	2.67E-05	2.69E-05	3.59E-05	5.14E-05	3.74E-05	4.12E-05	4.34E-05	3.58E-05	5.51E-05	2.87E-05	4.41E-05	1.53	0.616205439	0.003026798	1.198115693	up	0.004329004	Carboxylic acids and derivatives	--	--	HMDB0028707	7019985	2483-17-2	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_579	p-Cresol	0.000184333	6.18E-05	0.000245299	7.79E-05	0.000192418	0.000153471	8.09E-05	5.54E-05	7.66E-05	4.89E-05	6.24E-05	6.05E-05	0.000152532	6.41E-05	0.42	-1.250531249	0.027410933	1.009833483	down	0.025974026	Phenols	C01468	Metabolic pathways(ko01100)	HMDB0001858	2879	106-44-5	Benzenoids	Cresols
pos_582	Naringenin-7-O-Glucoside	0.000103367	6.15E-05	0.000225591	6.30E-05	0.000123866	7.43E-05	6.35E-06	1.81E-05	3.68E-05	1.41E-06	6.24E-06	0	0.000108608	1.15E-05	0.11	-3.240389995	0.011475782	1.105030371	down	0.002164502	--	--	--	--	--	--	--	--
pos_583	Podophyllotoxin (Podophyllum)	0.003373052	0.002144954	0.002603766	0.00215987	0.002767463	0.002161056	0.000504544	0.000375772	0.000677974	0.000225844	0.000364722	0.000595473	0.002535027	0.000457388	0.18	-2.470510276	5.41E-05	1.414243341	down	0.002164502	--	--	--	--	--	--	--	--
pos_585	(+-)-Mevalonolactone	1.09E-05	3.94E-06	1.35E-05	3.10E-06	1.25E-05	3.58E-06	4.94E-05	7.87E-05	7.70E-05	5.76E-05	5.85E-05	3.11E-05	7.92E-06	5.87E-05	7.42	2.890684948	0.00062578	1.344575531	up	0.002164502	--	--	--	--	--	--	--	--
pos_591	Azacitidine	0.000137102	0.000127478	0.000304783	0.000150524	0.000178058	0.000176314	3.89E-06	1.70E-05	1.80E-05	1.19E-05	2.69E-06	4.08E-06	0.000179043	9.60E-06	0.05	-4.221229959	0.001305309	1.296952001	down	0.002164502	Organooxygen compounds	--	--	HMDB0015063	9444	320-67-2	Organic oxygen compounds	Carbohydrates and carbohydrate conjugates
pos_592	Sophoraflavanone B	5.47E-05	5.93E-05	4.73E-05	4.40E-05	3.47E-05	3.95E-05	0.000181162	0.000371176	0.000196369	8.70E-05	0.000195459	0.000230847	4.66E-05	0.000210335	4.52	2.174911967	0.007270436	1.217666203	up	0.002164502	--	--	--	--	--	--	--	--
pos_596	2-Octenoic acid	6.86E-05	2.44E-05	3.46E-05	2.35E-05	5.42E-05	4.36E-05	6.05E-06	5.97E-06	7.76E-06	1.11E-05	7.73E-06	1.74E-05	4.15E-05	9.33E-06	0.22	-2.152405811	0.005774617	1.221598407	down	0.002164502	Fatty Acyls	--	--	HMDB0034565	5282714	188834-49-3	Lipids and lipid-like molecules	Fatty acids and conjugates
pos_597	Mimosine	1.78E-05	1.57E-05	2.60E-05	1.91E-05	2.05E-05	2.11E-05	2.68E-06	7.49E-06	6.75E-06	3.12E-06	1.95E-06	1.59E-06	2.00E-05	3.93E-06	0.2	-2.350398526	7.45E-06	1.365317059	down	0.002164502	Fatty Acyls	--	--	HMDB0031398	75052023	191936-12-6	Lipids and lipid-like molecules	Fatty alcohols
pos_600	Ononin	0.004305128	0.002028131	0.002984055	0.001920015	0.003655336	0.002918325	0.000497854	0.000422844	0.000459339	0.000297828	0.00037156	0.000732395	0.002968498	0.000463637	0.16	-2.678667124	0.00100377	1.344345589	down	0.002164502	Isoflavonoids	C10509	Isoflavonoid biosynthesis(ko00943)	HMDB0033987	3733033	486-62-4	Phenylpropanoids and polyketides	Isoflavonoid O-glycosides
pos_605	Leucyl-Methionine	8.85E-05	7.97E-05	0.000105344	0.000123364	0.000117004	0.000144138	0.000203672	0.000171297	0.000184214	0.000179812	0.000149564	0.000196793	0.000109682	0.000180892	1.65	0.721804764	0.000224087	1.325371565	up	0.002164502	--	--	--	--	--	--	--	--
pos_609	"MG(18_2(9Z,12Z)_0_0_0_0)[rac]"	2.72E-05	2.57E-05	2.76E-05	3.09E-05	3.09E-05	3.89E-05	5.98E-05	4.85E-05	5.75E-05	5.00E-05	4.54E-05	5.84E-05	3.02E-05	5.33E-05	1.77	0.819998556	3.23E-05	1.375110842	up	0.004998125	--	--	--	--	--	--	--	--
pos_610	Hygromycin B	2.29E-05	3.06E-05	1.45E-05	4.03E-05	1.23E-05	1.31E-05	0	0	0	0	0	0	2.23E-05	0	0	#NAME?	0.004770987	1.231633968	down	0.00277843	Organooxygen compounds	--	--	HMDB0034229	3659	31282-04-9	Organic oxygen compounds	Carbohydrates and carbohydrate conjugates
pos_616	5-methoxytryptophan	0.002184081	0.001952573	0.002537699	0.003089316	0.00298544	0.00363238	0.005198728	0.004478318	0.00488577	0.004603167	0.003889621	0.005273181	0.002730248	0.004721464	1.73	0.790202279	0.00014715	1.337543232	up	0.002164502	--	--	--	--	--	--	--	--
pos_618	[6]-Shogaol	6.04E-05	4.92E-05	4.03E-05	5.87E-05	5.86E-05	6.38E-05	8.00E-05	8.27E-05	7.71E-05	6.61E-05	6.70E-05	8.26E-05	5.52E-05	7.59E-05	1.38	0.460226043	0.001422124	1.217121182	up	0.002164502	--	--	--	--	--	--	--	--
pos_620	D-Proline	2.72E-05	2.18E-05	2.77E-05	2.75E-05	2.78E-05	3.07E-05	4.29E-05	3.85E-05	4.31E-05	4.15E-05	3.04E-05	4.58E-05	2.71E-05	4.04E-05	1.49	0.574774634	0.000892161	1.292716628	up	0.004329004	Carboxylic acids and derivatives	C00763	Arginine and proline metabolism(ko00330);;Metabolic pathways(ko01100)	HMDB0003411	8988	344-25-2	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_621	1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine	0.000101448	0.000243171	9.23E-05	0.000266349	0.000155736	0.000270222	0.00052436	0.00056511	0.000415461	0.000484824	0.000377857	0.000501927	0.00018821	0.000478257	2.54	1.345440926	6.85E-05	1.358004208	up	0.002164502	Glycerophospholipids	C04230	Glycerophospholipid metabolism(ko00564)	HMDB0013122	24779527	--	Lipids and lipid-like molecules	Glycerophosphocholines
pos_622	Lariciresinol	5.56E-05	9.92E-05	5.58E-05	7.67E-05	3.68E-05	5.90E-05	0.000118185	0.000126385	9.94E-05	7.55E-05	9.19E-05	0.000129361	6.38E-05	0.000106794	1.67	0.742195901	0.00595159	1.11636158	up	0.015151515	--	C10646	Biosynthesis of various secondary metabolites - part 2(ko00998);;Metabolic pathways(ko01100);;Biosynthesis of secondary metabolites(ko01110)	--	--	--	--	--
pos_623	Bosentan	0.001594923	0.001757754	0.001203185	0.002011713	0.001717378	0.001248277	0.000433815	0.000436733	0.000357165	0.000263177	0.000358925	0.000348263	0.001588872	0.000366346	0.23	-2.116722622	0.000148788	1.395673701	down	0.002164502	--	--	--	--	--	--	--	--
pos_626	Thymidine	0.06161552	0.045489824	0.14580599	0.070826972	0.081822539	0.071448584	0.007339296	0.016912619	0.014080766	0.006031235	0.005552379	0.00519789	0.079501572	0.009185698	0.12	-3.113522185	0.003956118	1.209603926	down	0.002164502	Pyrimidine nucleosides	C00214	Pyrimidine metabolism(ko00240);;Metabolic pathways(ko01100)	HMDB0000273	5789	50-89-5	"Nucleosides, nucleotides, and analogues"	Pyrimidine 2'-deoxyribonucleosides
pos_629	"3,4-Dihydroxymandelic acid"	0.001176577	0.001186588	0.001294226	0.001408989	0.001446377	0.00161717	0.002278363	0.001814101	0.001922522	0.001900937	0.001719997	0.002197986	0.001354988	0.001972318	1.46	0.54161191	0.000347828	1.303384073	up	0.002164502	Phenols	C05580	Metabolic pathways(ko01100);;Tyrosine metabolism(ko00350)	HMDB0001866	85782	775-01-9	Benzenoids	Benzenediols
pos_636	Vanylglycol	4.18E-06	4.23E-06	3.04E-06	3.46E-06	6.06E-06	4.18E-06	7.59E-06	6.79E-06	5.77E-06	5.10E-06	5.07E-06	6.93E-06	4.19E-06	6.21E-06	1.48	0.566899158	0.007300846	1.092112027	up	0.020022387	--	--	--	--	--	--	--	--
pos_637	L-phenylalanyl-L-proline	8.50E-05	7.40E-05	9.32E-05	0.000112719	0.000108252	0.000118399	0.000181149	0.000156007	0.000160271	0.000148336	0.000133046	0.000174677	9.86E-05	0.000158914	1.61	0.688374726	0.000132924	1.340572069	up	0.002164502	Carboxylic acids and derivatives	--	--	HMDB0011177	7020641	7669-65-0	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_639	Threoninyl-Glutamine	5.66E-06	3.61E-06	5.27E-06	4.90E-06	7.88E-06	9.98E-06	1.05E-05	8.48E-06	1.06E-05	8.82E-06	8.21E-06	1.30E-05	6.22E-06	9.94E-06	1.6	0.677191027	0.011779507	1.048543735	up	0.015151515	Carboxylic acids and derivatives	--	--	HMDB0029059	7016084	96337-79-0	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_640	Tyrosyl-Asparagine	2.55E-05	2.85E-05	2.34E-05	3.18E-05	2.22E-05	2.53E-05	4.08E-05	4.14E-05	3.14E-05	4.08E-05	2.67E-05	4.34E-05	2.61E-05	3.74E-05	1.43	0.519518607	0.007136641	1.149017808	up	0.020022387	--	--	--	--	--	--	--	--
pos_644	Linustatin	0.000342519	0.000199799	0.000565412	0.00016088	0.000321142	0.000221945	3.08E-06	1.02E-05	5.95E-06	3.12E-06	3.29E-06	3.06E-06	0.000301949	4.78E-06	0.02	-5.97991807	0.004283035	1.237128482	down	0.002164502	--	--	--	--	--	--	--	--
pos_646	16b-Hydroxyestradiol	8.40E-06	9.05E-06	5.81E-06	9.96E-06	1.17E-05	1.74E-05	2.00E-05	1.20E-05	2.28E-05	1.78E-05	2.08E-05	2.49E-05	1.04E-05	1.97E-05	1.9	0.924329131	0.003406069	1.120086758	up	0.004329004	Steroids and steroid derivatives	--	--	HMDB0000347	68929	547-81-9	Lipids and lipid-like molecules	Estrane steroids
pos_648	Amlodipine	0.008295081	0.004345638	0.012510644	0.006838911	0.009457459	0.006865301	0.000965935	0.002251914	0.001890779	0.000498747	0.000496755	0.00106607	0.008052172	0.001195033	0.15	-2.752327173	0.00132948	1.275988761	down	0.002164502	--	--	--	--	--	--	--	--
pos_650	Threoninyl-Isoleucine	2.50E-05	2.12E-05	2.72E-05	4.40E-05	5.83E-05	0.000111191	0.000122105	0.000103948	0.000195408	0.000131812	0.000151146	0.000211473	4.78E-05	0.000152649	3.19	1.67452352	0.000932717	1.21903676	up	0.004329004	Carboxylic acids and derivatives	--	--	HMDB0029064	57281443	129050-49-3	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_651	Clarithromycin	0.001490754	0.001128609	0.001153197	0.000937039	0.001544917	0.002127598	0.000520008	0.000670622	0.000526371	0.000572276	0.0003977	0.000430716	0.001397019	0.000519616	0.37	-1.426834828	0.003347572	1.234414875	down	0.002164502	--	--	--	--	--	--	--	--
pos_652	2-Thiocytidine	2.85E-05	4.05E-05	5.18E-05	3.15E-05	2.82E-05	2.88E-05	1.97E-05	1.89E-05	1.15E-05	6.21E-06	1.82E-05	2.83E-05	3.49E-05	1.71E-05	0.49	-1.024592402	0.005456038	1.085191096	down	0.004329004	--	--	--	--	--	--	--	--
pos_656	Icariin	0.000973515	0.001226352	0.002707518	0.002447972	0.001113983	0.002009362	0.000627661	0.000729795	0.000735558	0.000505367	0.000596392	0.000599778	0.00174645	0.000632425	0.36	-1.46545914	0.014017636	1.062268738	down	0.002164502	--	--	--	--	--	--	--	--
pos_658	Acyclovir	9.17E-06	9.20E-06	9.34E-06	1.02E-05	9.69E-06	9.02E-06	1.61E-05	1.56E-05	1.28E-05	1.38E-05	1.36E-05	1.62E-05	9.44E-06	1.47E-05	1.56	0.637438867	0.000165365	1.39786071	up	0.002164502	Imidazopyrimidines	--	--	HMDB0014925	2022	59277-89-3	Organoheterocyclic compounds	Purines and purine derivatives
pos_663	Lysyl-Aspartate	3.49E-06	3.53E-06	3.09E-06	5.43E-06	4.24E-06	3.56E-06	7.23E-06	1.02E-05	9.93E-06	7.40E-06	8.71E-06	1.37E-05	3.89E-06	9.52E-06	2.45	1.290813031	0.001359206	1.281809674	up	0.002164502	Carboxylic acids and derivatives	--	--	HMDB0028947	6426943	20556-18-7	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_665	3'-Hydroxyropivacaine	0.002294278	0.002198387	0.002392324	0.002801567	0.002950735	0.003286076	0.00467769	0.004355867	0.004470968	0.004089292	0.003875833	0.004951599	0.002653895	0.004403541	1.66	0.730553188	2.41E-05	1.379810694	up	0.002164502	--	--	--	--	--	--	--	--
pos_666	Sphinganine	0.00123897	0.001441895	0.001635883	0.00146729	0.001585835	0.00270591	0.003035678	0.002552969	0.004772327	0.002637796	0.00283854	0.003363152	0.001679297	0.003200077	1.91	0.930249139	0.004581551	1.150441961	up	0.008658009	Organonitrogen compounds	C00836	Sphingolipid metabolism(ko00600);;Metabolic pathways(ko01100)	HMDB0000269	91486	764-22-7	Organic nitrogen compounds	Amines
pos_667	10-hydroxy capric acid	8.41E-07	1.60E-06	9.53E-07	2.44E-06	3.80E-07	3.89E-06	9.59E-06	4.63E-06	9.06E-06	2.66E-06	6.85E-06	2.53E-06	1.68E-06	5.89E-06	3.5	1.805701634	0.019197389	1.049895967	up	0.008658009	--	--	--	--	--	--	--	--
pos_671	"Heptanoic acid, ethyl ester"	4.74E-05	3.40E-05	2.69E-05	3.43E-05	3.94E-05	4.11E-05	5.43E-07	1.50E-06	1.12E-06	2.98E-06	4.33E-06	5.02E-06	3.72E-05	2.58E-06	0.07	-3.848400415	3.55E-05	1.439446071	down	0.002164502	Fatty Acyls	--	--	HMDB0000798	7797	106-30-9	Lipids and lipid-like molecules	Fatty acid esters
pos_672	Butyl lactate	0.000495001	0.000225644	0.000201543	0.000222687	0.000402493	0.000323033	0.00059185	0.000746182	0.000473963	0.000728338	0.00066174	0.00088331	0.000311734	0.000680897	2.18	1.127123108	0.000648098	1.215595918	up	0.004329004	--	--	--	--	--	--	--	--
pos_674	Galactosylceramide (d18_1_18_0)	0.046872971	0.045701852	0.044567976	0.025808793	0.015495502	0.00885125	0.007414033	0.004468732	0.004125863	0.002997532	0.002147071	0.002267917	0.031216391	0.003903525	0.13	-2.999454496	0.010207662	1.167667378	down	0.002164502	--	--	--	--	--	--	--	--
pos_676	Aloin A	8.85E-05	1.51E-05	6.79E-05	1.59E-05	8.30E-05	5.30E-05	0	0	1.16E-05	0	0	1.40E-06	5.39E-05	2.17E-06	0.04	-4.633373111	0.010619032	1.158884307	down	0.004336913	Anthracenes	--	--	HMDB0035219	313325	8015-61-0	Benzenoids	--
pos_677	Alanyl-Lysine	8.34E-06	6.92E-06	7.50E-06	9.09E-06	9.09E-06	1.01E-05	1.40E-05	1.31E-05	1.21E-05	1.25E-05	1.01E-05	1.23E-05	8.50E-06	1.24E-05	1.45	0.539097838	0.000308535	1.312122177	up	0.006299951	Carboxylic acids and derivatives	--	--	HMDB0028692	7016106	6366-77-4	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_678	Pergolide	8.88E-06	7.03E-07	0	4.90E-07	2.53E-06	0	1.45E-05	3.25E-05	1.81E-05	6.00E-06	1.43E-05	2.02E-05	2.10E-06	1.76E-05	8.38	3.067573777	0.005843623	1.178245392	up	0.008127043	--	--	--	--	--	--	--	--
pos_680	Glutamyl-Valine	0.02050778	0.016045043	0.013580496	0.014674693	0.020228981	0.018572234	0.025549688	0.026687845	0.0206739	0.02902731	0.021830304	0.03041769	0.017268205	0.025697789	1.49	0.573526164	0.001945244	1.170207835	up	0.002164502	Carboxylic acids and derivatives	--	--	HMDB0028832	6992567	5879/6/1	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_681	Valeric acid	0.00028021	0.000202795	0.000190954	0.000222166	0.000317496	0.000281886	0.000361384	0.000383838	0.000294451	0.00044291	0.000339284	0.000398412	0.000249251	0.000370047	1.48	0.570106093	0.002136644	1.153253529	up	0.004329004	--	--	--	--	--	--	--	--
pos_683	Nobiletin	0.001338539	0.000692416	0.001565837	0.000674851	0.001251585	0.000858406	9.16E-05	8.83E-05	0.000106373	4.63E-05	5.66E-05	8.92E-05	0.001063606	7.97E-05	0.07	-3.737876117	0.001289727	1.325275387	down	0.002164502	Flavonoids	C09789	Flavonoid biosynthesis(ko00941)	HMDB0002927	442428	10236-47-2	Phenylpropanoids and polyketides	Flavonoid glycosides
pos_684	Pyridoxine 5-phosphate	0.000643847	0.000457246	0.000312758	0.000396335	0.000656254	0.0006314	0.000724156	0.001039319	0.000591602	0.000701285	0.000800345	0.001093801	0.000516307	0.000825085	1.6	0.676313922	0.013409788	1.013539983	up	0.015151515	Pyridines and derivatives	C00627	Metabolic pathways(ko01100);;Vitamin B6 metabolism(ko00750)	HMDB0001319	1055	447-05-2	Organoheterocyclic compounds	Pyridoxines
pos_686	Formononetin	0.000665432	0.000387019	0.000639352	0.000424508	0.000710648	0.000656619	0.000166655	0.000218698	0.00019426	0.000108761	0.000123243	0.000125118	0.000580596	0.000156123	0.27	-1.89485455	0.000365501	1.341077436	down	0.002164502	Isoflavonoids	C00858	Biosynthesis of secondary metabolites(ko01110);;Isoflavonoid biosynthesis(ko00943)	HMDB0005808	5280378	485-72-3	Phenylpropanoids and polyketides	O-methylated isoflavonoids
pos_687	Tridecanoic acid (Tridecylic acid)	8.92E-05	7.26E-05	0.000137677	8.96E-05	0.000107706	0.000100711	0.000172992	0.00021499	0.00025133	0.00025876	0.000183765	0.00031258	9.96E-05	0.000232403	2.33	1.222522158	0.000819482	1.292379194	up	0.002164502	--	--	--	--	--	--	--	--
pos_690	Kojic Acid	2.02E-05	1.14E-05	1.26E-05	1.07E-05	2.05E-05	1.56E-05	1.98E-05	2.81E-05	2.32E-05	1.74E-05	3.12E-05	3.70E-05	1.52E-05	2.61E-05	1.72	0.783716778	0.013955876	1.005042739	up	0.025974026	--	--	--	--	--	--	--	--
pos_692	Leukotriene D4	0.000127944	0.000127592	0.000162387	0.000177481	0.000146106	0.000183691	0.000260657	0.00022245	0.000269345	0.000218308	0.000196114	0.000244637	0.0001542	0.000235252	1.53	0.609401946	0.000332688	1.314027724	up	0.002164502	Fatty Acyls	C05951	Arachidonic acid metabolism(ko00590);;Metabolic pathways(ko01100)	HMDB0003080	5280878	73836-78-9	Lipids and lipid-like molecules	Eicosanoids
pos_693	Acetyl coenzyme A (Acetyl-CoA)	4.96E-06	7.89E-06	1.72E-05	1.04E-05	9.47E-06	9.36E-06	0.000111072	2.31E-05	4.24E-05	6.48E-05	5.95E-05	0.000106565	9.89E-06	6.79E-05	6.87	2.780035387	0.009367932	1.157164816	up	0.002164502	--	--	--	--	--	--	--	--
pos_694	Camptothecin	0.00081136	0.001550354	0.001273081	0.002195303	0.001124841	0.001824112	0.000362582	0.000636282	0.000376421	0.000356707	0.000344685	0.00021954	0.001463175	0.000382703	0.26	-1.934806412	0.002508934	1.216093719	down	0.002164502	--	--	--	--	--	--	--	--
pos_699	Methionyl-Tyrosine	0	0	0	0	0	0	1.52E-05	5.01E-06	3.42E-05	3.46E-05	1.77E-05	2.36E-05	0	2.17E-05	Inf	Inf	0.005698451	1.192030664	up	0.00277843	--	--	--	--	--	--	--	--
pos_704	Methacycline	0.000559464	0.000355771	0.0003013	0.000527155	0.000799504	0.000671251	0.000222224	0.000248079	0.000230058	0.000167039	0.000215021	0.000152066	0.000535741	0.000205748	0.38	-1.380657378	0.006984135	1.177559799	down	0.002164502	--	--	--	--	--	--	--	--
pos_705	Threoninyl-Arginine	1.21E-05	1.21E-05	1.22E-05	1.66E-05	1.56E-05	1.83E-05	2.67E-05	2.06E-05	2.38E-05	1.87E-05	1.99E-05	2.58E-05	1.45E-05	2.26E-05	1.56	0.640935691	0.000978755	1.252208073	up	0.004998125	Carboxylic acids and derivatives	--	--	HMDB0029055	7016110	13448-26-5	Organic acids and derivatives	"Amino acids, peptides, and analogues"
pos_711	4-thiouridine	0	2.08E-07	0	1.51E-07	4.70E-08	6.16E-08	5.23E-06	8.97E-08	1.78E-06	6.34E-06	3.60E-06	7.22E-06	7.79E-08	4.04E-06	51.9	5.697590077	0.016593584	1.06988002	up	0.01290657	--	--	--	--	--	--	--	--
pos_712	5-oxo-pentanoic acid	8.51E-06	1.04E-05	9.75E-06	1.29E-05	1.43E-05	1.51E-05	2.41E-06	1.09E-06	1.99E-06	2.62E-06	2.88E-06	2.94E-06	1.18E-05	2.32E-06	0.2	-2.348631763	0.000194198	1.373212404	down	0.002164502	Fatty Acyls	C03273	Metabolic pathways(ko01100);;Lysine degradation(ko00310)	HMDB0012233	439963	5746/2/1	Lipids and lipid-like molecules	Fatty acids and conjugates
pos_717	Atorvastatin	0.000360198	0.000226141	0.000343278	0.000474825	0.000377107	0.000573461	0.000921551	0.000721652	0.000759995	0.000759279	0.000633602	0.000965512	0.000392502	0.000793599	2.02	1.01571141	0.000207776	1.31279418	up	0.002164502	--	--	--	--	--	--	--	--
pos_718	15-keto-Prostaglandin E2	7.83E-06	7.04E-06	7.42E-06	7.41E-06	9.25E-06	8.47E-06	1.26E-05	1.17E-05	1.22E-05	1.18E-05	1.12E-05	1.12E-05	7.90E-06	1.18E-05	1.49	0.577508895	5.73E-06	1.408618994	up	0.004998125	Fatty Acyls	--	--	HMDB0003175	5280719	26441-05-4	Lipids and lipid-like molecules	Eicosanoids
pos_719	D-Neopterin	8.91E-06	1.38E-05	1.05E-05	1.34E-05	8.07E-06	9.04E-06	2.07E-05	1.52E-05	1.29E-05	2.01E-05	1.14E-05	1.58E-05	1.06E-05	1.60E-05	1.5	0.589333559	0.017287026	1.030228316	up	0.025974026	Pteridines and derivatives	C05926	Folate biosynthesis(ko00790)	HMDB0000845	4455	2009-64-5	Organoheterocyclic compounds	Pterins and derivatives
pos_720	Picolinic acid	9.38E-06	1.04E-05	9.17E-06	1.04E-05	1.16E-05	1.10E-05	1.94E-05	1.85E-05	1.75E-05	1.54E-05	1.67E-05	2.10E-05	1.03E-05	1.81E-05	1.75	0.80709549	4.91E-05	1.398588863	up	0.004998125	Pyridines and derivatives	C10164	Metabolic pathways(ko01100);;Tryptophan metabolism(ko00380)	HMDB0002243	1018	98-98-6	Organoheterocyclic compounds	Pyridinecarboxylic acids and derivatives
pos_721	Phenylacetic acid	0.000473072	0.000171759	0.00052721	0.000212904	0.000465315	0.000415157	0.000167507	0.000114349	0.000153311	0.000100697	0.000128819	0.000126485	0.000377569	0.000131861	0.35	-1.517721166	0.009245768	1.153747445	down	0.002164502	Benzene and substituted derivatives	C07086	Phenylalanine metabolism(ko00360);;Metabolic pathways(ko01100)	HMDB0000209	999	103-82-2	Benzenoids	--
pos_723	Esculetin	4.17E-06	3.80E-06	4.20E-06	4.09E-06	5.86E-06	5.77E-06	9.11E-06	1.04E-05	2.22E-05	6.51E-06	1.15E-05	1.27E-05	4.65E-06	1.21E-05	2.6	1.376582653	0.019194726	1.073551859	up	0.002164502	Coumarins and derivatives	--	--	HMDB0030819	5281416	305-01-1	Phenylpropanoids and polyketides	Hydroxycoumarins
pos_724	Coenzyme Q1	2.36E-05	4.09E-05	2.78E-05	5.31E-05	1.65E-05	2.40E-05	4.04E-06	1.05E-06	4.33E-06	1.02E-06	2.96E-06	6.27E-06	3.10E-05	3.28E-06	0.11	-3.241213713	0.003710847	1.230085109	down	0.002164502	Prenol lipids	C00399	Ubiquinone and other terpenoid-quinone biosynthesis(ko00130);;Oxidative phosphorylation(ko00190);;Biosynthesis of secondary metabolites(ko01110);;Metabolic pathways(ko01100)	HMDB0006709	5280346	606-06-4	Lipids and lipid-like molecules	Quinone and hydroquinone lipids